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OTAR3088
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BioData-CellLine_annotated

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PMC11495567
Matrigel spheroids independently treated with 10 μM of NSL-YHJ-2-27 (Fig 8A) and NSL-YHJ-2-46 (Fig 8B) for 144 h, demonstrated a significant decrease in invasion area of NCI-H23 cells by 87 ± 0.1 and 92 ± 0.2%, respectively, relative to the controls. (
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PMC9429973
V. Gianfelici, L. Levato, D. Magro, E. Piro, C. Santamaria, L. Scalise, P. Marinaro, D. Loiacono, A. Mannella, A. Russo, L. Tucci, M. Rossi Department of Hematology-Oncology; Department of Pathological Anatomy, “Pugliese-Ciaccio” Hospital; Department of Experimental and Clinical Medicine, Magna Graecia University, Cata...
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PMC9792775
Dimethyl sulfoxide (DMSO) was purchased from Beijing North Chemical Fine Chemicals Co., Ltd. (Beijing, China).
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PMC11680982
Strikingly, neratinib reversed the efficacy of CDK4/6 inhibitor and endocrine therapy by reducing HER2 mRNA stability in HR/HER2-low breast cancer through the interaction of HER2 3’-UTR region with hsa-miR-23a-5p.
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PMC11538390
Three independent clones each of heterozygous (TG), and homozygous risk (GG), and two clones of the homozygous non-risk (TT) genotype were isolated.
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PMC8010066
The 2 method was used to determine the expression levels.
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PMC11740573
The lowest concentration in which no bacterial growth was observed (blue/purple color in well), was defined as MIC.
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PMC11637284
The overarching principle of TAC biogenesis is a polar assembly of its subunits starting at the BB.
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PMC11297139
4ARID1A LLPS-dependent altered transcriptome and epigenome.a A heatmap illustrating expression of DEGs (FDR < 0.05) obtained from the RNA-seq results of WT, ARID1A, five ARID1A + WT, five ARID1A + ΔDD, and ARID1A + PrLD(Y/S) A673 cell lines.
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PMC11675244
Collectively, these pathways promote processes like EMT, CSCs maintenance, and therapy resistance, illustrating a cooperative contribution to tumor progression and treatment evasion .
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PMC11566417
Finally, the relative decrease in enrichment of supramolecular fiber organization and cell motility (#4 and 5), both associated with cell migration [73–75], between primary p10 and p20, as opposed to the opposite trend between immortalized p10 and p20, coincides with our findings that immortalized MDEC CM better mainta...
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PMC11461833
In addition, hub gene analysis of gene-gene interaction networks were performed via the GeneMANIA online analysis tool (https://genemania.org), a popular and powerful tool for exploring the functions of genes and their interactions within complex biological networks.
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PMC9429973
BCAT1 promoter occupancy by NOTCH1 was determined by Chromatin Immunoprecipitation (ChIP) coupled with qPCR.
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PMC7812570
The expression levels of GPI-m36.4 and GPI-FluIgG03 were detected by FACS analysis with an anti-His tag antibody.
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PMC10940855
H, Mean percentages of CD138GFP multiple myeloma cells in the spine and PB in NSG at 7 weeks after transplantation of U266 cells transduced with dEFBN2 or GFP control (n = 5–10/group).
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PMC11627398
The p < 0.05 was set as the threshold to screen miRNAs and lncRNAs that were significantly correlated to hub genes.
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PMC9429973
A. Elazab, M. Denewer, M. Mabed Oncology Center, Mansoura University; Oncology Center, Mansoura University; Oncology Center Mansoura University, Mansoura, Egypt Background: Previous studies have demonstrated an association between high body mass index (BMI) and acute myeloid leukemias (AML).
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PMC6450504
These results indicate that the surface modification of the liposomes with bPEI imparts higher stability to the nanoformulations in serum-containing media and helps to prevent drug leakage.
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PMC10745221
PRMT1 and PRMT5 are the major Type I and Type II enzymes and are responsible for the majority of ADMA and SDMA marks on proteins, respectively .
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PMC11765243
Treg-specific deletion of PI3K isoforms show no significant effect of p110α deletion and confirms the major role of p110δ in normal Treg differentiation and function .
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PMC11023271
It is worth noting that the impact of RIPK4 knockdown on LPA-induced proliferation was not drastic, although statistically significant.
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PMC11023271
A, B) The level of RIPK4 mRNA in HaCaT (A) or A431 (B) cells was reduced after treatment by FBE and FBS.
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PMC11751675
In their chemical investigation of Tanacetum vulgare L., Onozato and colleagues identified a germacranolide-type sesquiterpene lactone known as parthenolide (31) isolated from Tanacetum parthenium L., commonly referred to as feverfew.
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PMC11726183
The CH2 of the benzyl moiety attached to the N position of the isatin appeared as a singlet in the region of 4.96–5.04 ppm.
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PMC8632470
In the body, NAPQI binds to selenium protein and glutamine synthetase at the S3 segment of the proximal tubule, which causes an increase of xanthine oxidase (XOD) activity; thus, the production of reactive oxygen species (ROS) is also enhanced .
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PMC8956657
A list of hydrogen-bonded interactions is presented in Supplementary Table 8.
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PMC2777936
The Wnt signalling pathway is essential for normal eukaryotic development and inappropriate activation of Wnt signalling occurs in many cancers .
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PMC8992508
Some functionalized chromones were described as highly active compounds as MDR modulators.
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PMC11514418
In addition, APS alleviated the hepatic pathological damage in mice caused by epirubicin, cyclophosphamide, and docetaxel, which may be related to decreased cell senescence biomarkers, oxidative stress, and NOD-, LRR- and pyrin domain-containing protein 3-mediated pyroptosis and apoptosis via the adenosine monophosphat...
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PMC11247842
Moreover, multi-trait analysis of highly correlated traits can boost power by using information from multiple traits to prioritize common genetic mechanisms .
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PMC11413393
Cells were plated in 10 cm culture dishes at ~60% confluence and incubated for 24 h with 5 μM MS023, 2 μM NU7441 (DNA-PK inhibitor, gift from Dr. Shane Harding) or 0.1% DMSO.
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PMC9429973
As its mechanism of action and safety profile are distinct from IC, epcoritamab is well suited for use in combination therapy and in earlier lines of therapy.
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PMC11752740
Fig. 8The effects of pistachio hull extract (E), carfilzomib (CFZ), and their combination on NF-κB P65 gene expression levels in SK-BR3 and MCF10A cell lines.
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PMC11490153
This suggests that their anticancer effects may be due to direct activation of the apoptosis pathway.
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PMC9429973
Two (P5 and P8) were born small for gestational age, P5 presented with global developmental delay and cerebellar atrophy.
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PMC11725127
The activities of the R289L (Fig. 3G and H) and P565A (Fig. 3I and J) mutants were less inhibited by GA compared with that of the WT, agreeing with the molecular docking results that P565 and R289 were critical for the GA-USP2 interaction.
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PMC8956657
MERS-CoV ORF4b bound both the major NLS binding site, through residues Arg, Lys, Arg, and Arg, as well as the minor site through residues Lys, Arg, and His, in both IMPα2 and IMPα3 (Fig. 1E, F).
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PMC11402217
Scale bars = 200 μM. (D and E) Changes of mRNA expression related to EMT differentiation after XD23 (0.5 μM) stimulation in 143B cells and MG63 cells. (
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PMC10154881
In addition, we found that NK cells played a role in our therapy.
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PMC11704135
Compound 6 exhibited lower efficacy compared to compound 1.
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PMC9341513
We note that although the simulations are consistent with the in vivo trends, we would not expect the model to be able to predict quantitative differences in probe volumes; this is consistent with previous work where predictions for 3C-based data (interactions) were better than those for microscopy data (Buckle et al. ...
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PMC9219615
In addition, two colorectal adenocarcinoma cell lines, COLO 205 (ATCC CCL-222) and HT-29 (ATCC HTB-38), were identically maintained in RPMI-1640 complete medium.
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PMC11696576
The structure of AVX420 and AVX420 acid were sketched and optimized using Maestro software (Schrödinger, Inc., NY, USA), and the docking simulation was performed using Glide software (Schrödinger, Inc., NY, USA).
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PMC10747160
However, the MNE virus concentration could be artificially inflated by containing a high number of SARS-CoV-2 coronavirus-like particles (cVLPs).
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PMC10758402
To monitor viral infection, GFP images were captured, and supernatants were collected at 72 hpi.
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PMC10490530
A2780 cell line stably expressing pNF-κB-hLuz (A2780-NhLuz) was also generated by clonal selection and denoted as A2780-NhLuz.
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PMC9429973
Methods: We retrospectively reviewed data from patients diagnosed with de novo AML in our laboratory during january 2013 and december 2020.
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PMC7840816
Knockdown of SOX9 inhibited the proliferation of TPC-1 cells in a time-dependent manner. (
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PMC11286266
After each association, the sensor was dipped into a buffer containing well to allow dissociation for 2400s.
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PMC6160470
Correlation analysis of P-gp inhibitory effect and AlogP values showed linear regression for MACs (R = 0.3739) and DACs (R = 0.4092) with optimal AlogP value for the best P-gp inhibition around 4.
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PMC11562028
At the same time, the Re-CDs showed low toxicity and side effects, and good biosafety.
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PMC10926885
The expression data for NDE1 were obtained from the TCGA database.
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PMC10530622
Wang and colleagues (2021) reported that the up-regulation of the nuclear factor erythroid 2-related factor/heme oxygenase-1 (Nrf2/HO-1) pathway by circadian clock gene brain and muscle ARNT-like 1 (BMAL-1) attenuated urinary CaOx stones formation.
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PMC11687663
But the molecular docking report suggest that, the unstable nature of Quercetin (B12) binding against receptor hinder the therapeutic efficacy of drug.
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PMC11435360
Our hematoxylin and eosin staining showed that the BBN saline group had 100% normal tissue while the BBN saline and BBN PAG groups had 0% and 16.7% normal tissue, respectively (Figure 3C).
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PMC10114490
Commercial HDF at passage 4 were infected with a lentiviral vector constitutively expressing hTERT (Fig. 1A; diHLC-T).
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PMC11323699
The quantification was conducted using the H-score system, combining staining intensity (0, + 1, + 2, + 3) with the percentage of positive cells (0 to 100) for a score of 0 to 300.
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PMC11473843
The KAPA HotStart Mouse Genotyping Kit (Kapa Biosystems, KK7352) and KAPA2G Fast HotStart Genotyping Mix (Kapa Biosystems, KK5621) were used to perform the genotyping, according to the manufacturer’s instructions.
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PMC11541409
Primary GIST cells with PDGFRA mutations (V561D, SPDHE566-571R and insertion ER561-562) are sensitive to imatinib treatment in vitro (IC50 < 200 nM) .
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PMC10743717
This dehydrogenase can bind with the Aβ peptide thereby enhancing neurotoxicity to brain cells.
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PMC11087055
Streamlines, visualizing averaged cell flows during each time period. (
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PMC11320084
The t test was used to compare measurement data between the two groups.
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PMC9429973
Cytokine’s plasma levels were determined by Cytometric Bead Array (BD).
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PMC7917457
The number of presensitized effector cells was 2.5 × 10 cells per well (0.5 × 10 for a T cell clone), and ELISpot incubation time was 16 h. PeptiCRAd complexes were prepared by mixing VALO-D102, VALO-mD901, or Ad5/3-D24 adenoviruses (in A195 storage buffer) and polyK-extended epitopes (in 0.9% saline) at a ratio of 1.8...
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PMC11699465
Effect of TMEM199 on PD-L1 degradation (A) Mean fluorescence intensity in cytoplasmic membrane when TMEM199 was knocked out.
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PMC11359735
Published mass spectrometry-based proteomic analyses of sporozoites failed to detect peptides corresponding to the predicted GPI addition site (red arrow) and downstream residues, consistent with prior processing of the protein and removal of the putative GPI-addition sequences.
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PMC9429973
At last follow-up, 724 (11.5%) patients had died, of which 65% were due to malignant neoplasms.
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PMC11240448
Whereas core network molecular components are described by their concentrations or activity levels, the DPD nodes are described by the DPD scores.
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PMC11377827
The following day, cells were incubated in 21 or 1% oxygen for 6 h, washed twice in 1x DPBS and fixed with 4% paraformaldehyde for 15 min.
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PMC11544771
In this study, CPX treatment dose-dependently increased p-Chk1 (S345) and p-Chk1 (296) in A549 and A427 cells (Figure 3).
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PMC10761218
Similarly, HepG2 exhibited cell viability of 86.09 ± 0.020, 36.21 ± 0.011, 22.16 ± 0.017, 19.85 ± 0.015, 10.01 ± 0.025, 10.04 ± 0.025, and 10.04 ± 0 0.025, at 20, 50, 100, 200, 500, 1000, 1500, and 2000 μg/mL concentrations, respectively, with stem extracts (Table 2).
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PMC10778532
Sunitinib may potentially slow down healing and proliferation in VHL-C162F cells by inhibiting P-ERK.
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PMC11686380
Although the variant was previously reported in dbSNP (rs369966812), its frequency was extremely low; 0.000038 in the Trans-Omics for Precision Medicine (TOPMED), 0.000092 in the Genome Aggregation Database (GnomAD) exome database, and 0.000064 in GnomAD genome database.
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PMC10969097
Other terms: (synergy OR combined effect OR synergistic interaction OR potentiation OR interaction) or (chemoresistance OR treatment resistance OR drug resistance OR mechanisms of resistance OR treatment).
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PMC10421378
Probiotic cells can also adhere to the extracellular matrix (ECM) proteins secreted by Caco-2 cells, such as laminin or collagen.
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PMC11380329
Natural products were explored as an adjuvant treatment to improve therapeutic outcomes.
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PMC11413393
Significant inhibition of tumor growth was noted for both RCC243 and 786-0 cell line xenografts relative to controls (Fig. 8a).
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PMC7090062
Hsa-miRNA-30a mimic, hsa-miRNA-30a inhibitor, and nonspecific control were purchased from RiboBio (Guangzhou, China).
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PMC11796104
GO analysis indicated several significantly enriched terms, such as, protein transport (p = 5.06E-20), viral process (p = 3.33E-16), cytoplasm (p = 6.40E-62) and protein binding (p = 3.99E-107) (Fig. 3A-C).
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PMC11754436
The weight were measured. (
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PMC7685376
Then, the labeled samples of each iTRAQ analysis were pooled and mixed in equal proportions, dried by vacuum centrifugation, and prepared for fractionation by IEF separation.
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PMC8864075
After literature research, the PI3K/Akt signaling pathway attracted our attention, which could significantly activate tumor metastasis and directly regulate the expression of TWIST1, one of the key markers in EMT.
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PMC11740907
Following the recommendations of the institution’s ethical committee (256/PEC/2023), the animals were housed and cared for humanely.
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PMC11476222
The first extraction method was Folch extraction , where the homogenate was mixed with chloroform and methanol in a 2:1 (v/v) ratio, along with 0.9% NaCl.
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PMC11628309
The rise in life expectancy, resulting from advancements in medical treatments, and overall quality of life, has promoted the appearance in the population of previously relatively uncommon age-related conditions, such as neurodegenerative diseases (Azam et al., 2021).
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PMC6182045
The concentration of rgp120 in growth conditioned cell culture supernatant was quantitated using a capture ELISA.
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PMC11499381
This AF-647 thresholding acted to select regions within the image that displayed myc-like immunoreactivity above background levels, which we use as a proxy for RAMP1 detection in transfected cells.
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PMC9429973
Results: We found variable BCAT1 expression levels amongst the different T-ALL molecular subgroups, with higher expression levels in TLX1 (p<0.001), HOXA-TLX3 (p<0.05) and NKX2-1 (p<0.01) subtypes.
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PMC9581083
Different combinations of TCM compounds may improve therapeutic efficacy.
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PMC9429973
Secondary endpoints are duration of response, defined as duration of sustained platelet count ≥50×10/L between the end of treatment and end of study (duration does not consider the 4 weeks following the last daratumumab injection in the study); time to treatment failure defined as the time with platelet count ≥50×10/L ...
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PMC9429973
Image: Summary/Conclusion: Herein, we demonstrate for the first time a machine learning-based genomic testing solution for the detection and classification of aggressive B-NHL, based on H&E stained slide images.
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PMC8996378
The measurement of catalytic activity is a means of investigating candidate regulators as substrates or inhibitors, and inhibited the verapamil-stimulated ATPase activity, being a complete inhibition attained at 50 and 100 μM. The effects of compound 6 on the ATPase activity of ABCB1 showed it to interact with the tran...
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PMC11640419
It is not uncommon for multiple mechanisms of cell death to be present in a single cell when it is subjected to the effects of a toxic agent under investigation.
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PMC11676670
Although TP53 mutations are predominant in HGSOC cases, we found no mutations in TP53 hotspots in OVAR79 cells.
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PMC2193049
MAGE-3 belongs to the human MAGE multigene family, is characterized by its tumor-restricted expression, and gives rise to several antigenic peptides presented by different MHC class I molecules (15–17).
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PMC10988808
These findings highlight the potential of CCDC25 as a therapeutic target in ccRCC treatment.
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PMC11401358
4Studies on the antioxidant effect and structure of (GAGSGA)2 in silk after H2O2 treatment. (
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PMC10667689
Reviewing current knowledge on fatty acids, palmitate is one of the agonists of toll-like receptors; therefore, it can actively promote immune response (77).
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PMC11551844
Based on the IC50 values, AuNPs-contignasterol displayed less activity than contignasterol on the A172 cell line and there was no significant difference of activity on the HaCaT cell lines.
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PMC11502962
Next, 70-µm cell strainer was used for filtration.
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