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PMC11774747
Thus, the TCR diversity originally present in the VST is maintained.
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PMC9325715
z o.o. (
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PMC11640115
This study showed that the imGPS can be a robust predictive marker for the prognosis and therapeutic efficacy of pembrolizumab for RMHNC compared with previously reported NLRs and mGPSs.
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PMC11087055
In contrast, this Pk1-localization pattern was not identified in the ΔDEP-GFP-misexpressing PS and epiblast cells (Figure 1—figure supplement 1C–D, n=3), implying that the construct efficiently disrupted the cellular polarity within the misexpressing cells.
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PMC11489175
In ovarian cancer, USP14 has been reported to be over-expressed as compared to normal tissue in early studies 67, 68.
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PMC9919300
Andrographis paniculate also known as the king of bitters belongs to the Acanthaceae family.
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PMC5811757
Over the past three decades, considerable variety of ABCB1 inhibitors have been emerged; however, none of them have been approved for clinical use.
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PMC8143558
Ex Gaertn) G. Don’ and Kalanchoe pinnata (Lam) Pers.
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PMC11640476
The Limit of Blank (LoB), Limit of Detection (LoD), and Limit of Quantification (LoQ) were calculated using the calibration curve method .
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PMC11615218
Similar results were demonstrated by Bai et al. through cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) analysis, showing that frequencies of TSCM and TCM from CAR-T infusion products could distinguish relapse in patients .
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PMC6642070
Co-administration of DCA is a potential avenue to alleviate the symptoms.
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PMC11724582
Fig. 4The Hippo signaling pathway is correlated with third-generation EGFR-TKI resistance.
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PMC8777939
However, chemotherapy is often limited by toxic side effects to the vital organs.
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PMC8540692
Briefly, after 48 h incubation with the analyzed compounds, the cells were trypsinized, washed with PBS buffer, fixed in ice-cold 70% ethanol, and stored until staining at −20 °C.
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PMC9429973
The pattern of presentation including systemic involvement and CSF features inform treatment strategies, which include CNS-penetrating therapies.
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PMC10507284
After rinsing the tissue, add 200 μL chloroform (Sigma) and leave for 15 min on ice.
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PMC10976516
We should also be realistic in accepting that murine and human immunity does have some intrinsic differences, which apply to advanced syngeneic lung cancer models.
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PMC10831439
Importantly, flow cytometric analysis of expanded cells revealed that our protocol did not induce cell exhaustion, despite the prolonged culture time (figure 1C).
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PMC10719213
Each participant gave informed consent for blood sampling for this research.
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PMC11703896
Rapamycin is considered as a miracle drug because of its unique ability to act against different diseases (Hanley et al., 2019).
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PMC10073922
In addition, 5-years survival time of patients with low NDRG2 expression was shorter than those with high NDRG2 expression .
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PMC11683240
The stronger the color, the longer the residues interacted.
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PMC11633763
The use of All animal experiments were approved by the Animal Experimental Ethics Committee of the Second Affiliated Hospital of Nanchang University.
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PMC11348300
In instances where tissue oxygen levels did not reach equilibrium after palpation, reoxygenation time fitting was conducted utilizing prepalpation resting values as the baseline for equilibrium.
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PMC11754432
Median fluorescence intensity of propidium iodide (I) following 1 h streptolysin O pore formation measured by flow cytometry (N = 5).
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PMC10317042
Vorinostat was administrated at 50 or 20 mg/kg by intraperitoneal injection once daily.
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PMC11703992
We specifically extracted and re-clustered T cell groups from GCA samples into 13 individual groups (Fig. S1E, F).
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PMC9895440
Injecting three times the number of CARs did not improve the survival for CART19-28z intergenic, while CART19-28z SNX9 KO again led to higher survival (Supplementary Fig. 10a, b).
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PMC11075223
Cimigenoside (5 μM, 10 μM, 20 μM) induced apoptosis in breast cancer cells and inhibited presenilin 1 activity by down-regulating Notch intracellular domains expression in the nucleus, thereby repressing Notch protein cleavage and γ-secretase hydrolysis activity .
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PMC11539788
The wound healing rate was determined using the following formula: wound healing rate = (wound area at 0 h – wound area at 36 h)/wound area at 0 h×%.
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PMC11786767
Next, we applied a Zeiss LSM980 confocal laser scanning microscope with an AiryScan 2 area detector to acquire super-resolution images of COS-7 cells stained with DAPI.
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PMC9429973
Efficacy outcomes, including overall response rate (ORR), complete response (CR) rate, and progression-free survival (PFS), were compared among the efficacy-evaluable set, defined as patients with ≥12 months of follow-up in both trials.
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PMC11144200
n = 3, **P < 0.01, ***P < 0.001, ****P < 0.0001.
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PMC9429973
At individual level, most patients (≥60%) experienced either clinically meaningful improvement or no change while on treatment in all domains.
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PMC9429973
Results: As of Feb 2022, 188 pts have received crizanlizumab in the MAP, of whom 87 have been treated for ≥12 months (Brazil, n=79 [91%]; Italy, n=5 [6%]; Spain, n=2 [2%]; Israel, n=1 [1%]).
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PMC11637284
Immunoblot analyses of pulldown experiments of the two days tet-induced TAC60-RNAi cell line complemented by TAC60ΔC283-myc performed in the presence of 500 (A) and 750 (B) mM NaCl.
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PMC8998437
We revealed that CCR1 is expressed at high mRNA and protein levels in two CD10-negative BL cell lines with co-expression of the EBV latent genes EBNA2, LMP1, and LMP2.
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PMC10047551
Altogether, these results lead us to question the impact of PD-L1 methylation in driving the repression of PD-L1 mRNA expression.
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PMC9429973
Combined pharmacologic inhibition of SYK and FLT3 results in robust antileukemic effects in preclinical models of FLT3 ITD-driven AML.
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PMC11566417
Of note, the GO-terms for cytoskeleton organization and cell junction organization (#1 and 2), both related to angiogenic processes, were found to be diminished in the CM from p20 MDECs, both primary and immortalized (Fig. 6b).
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PMC11566417
There were no observable trends or differences, biologically nor statistically, in ROS accumulation in neutrophils treated with primary or immortalized p10 or p20 MDEC CM (Fig. 5b).Fig.
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PMC9429973
Methods: In total, 59 patients were enrolled (median age, 69 years; range, 46-91 years) of which 48 patients completed at least six cycles of induction with IRd; 41 patients (median age 66 years, 66% male) with at least a minimal response (MR) continued to 2 years of rituximab maintenance (1400 mg s.c.,
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PMC11723947
B6 Foxp3-Thy1.1 mice were provided by A Rudensky (Howard Hughes Medical Institute, Seattle).
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PMC8358006
Spearman correlation coefficients.
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PMC11705067
Human ccRCC cell lines 786-O and A498 were purchased from the American Type Culture Collection (Rockville, MD, USA) and maintained at 37°C in a humidified, 5% CO2 controlled atmosphere in RPMI medium 1640 and MEM medium supplemented with 10% fetal bovine serum and 1% penicillin/streptomycin, respectively.
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PMC11240448
However, there was diminished confidence in predicting BC subtypes, particularly the transitions between luminal and basal-like subtypes.
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PMC9429973
To perform knockout screens, a split-construct for Cas9 was used to reduce plasmid size and optimize lentiviral transduction efficiency into PDX cells; concomitantly split-GFP was used to enrich cells expressing both Cas9 split plasmids by flow cytometry.
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PMC11656657
B Tumor growth was evaluated by In vivo imaging system (IVIS) for all three different orthotopically models (200′000 cell/mice).
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PMC11739504
Microtubules, which have α-tubulin as their subunit, act as a highway for many molecules, including IFT particles.
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PMC11467964
Furthermore, the meta‐cohort of STS cohorts was generated using “Combat” algorithm.
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PMC11795610
After reaching confluency, the cells were cultured for 6 days in KM-d medium supplemented with 1.8 mM CaCl2 to induce keratinocyte differentiation.
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PMC3675084
Argon was the collision gas.
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PMC8303372
Moreover, since the toxic effect of a compound depends on how it is administered (vehiculated by a carrier or in solution), the cytotoxicity caused by GA on a cell line of hepatocellular carcinoma, both free and in encapsulated form, was evaluated.
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PMC11754094
To identify gRNA sequences within the sequencing data, we utilized BWA-mem.
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PMC9545714
This would compromise the barrier function of the skin and lead to elevated TEWL.
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PMC11519788
Utilizing a transwell assay, we assessed macrophage migration in response to co-culture with UBC cells.
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PMC11802929
Antigen-specific CD8 T cells were identified as those that belonged to the same GLIPH group of the SARS-CoV-2 specific TCRs identified in this study.
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PMC9429973
This sub-analysis is based on the final November 23, 2020 database lock.
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PMC9429973
Fig 1 shows age distribution and COVID-19 severity by disease severity groups.
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PMC9429973
R. Tonino, M. Schipperus, J. J. Zwaginga Hematology, LUMC; Research, TRIP, Leiden; Hematology, UMCG, Groningen; CCTR, Sanquin, Amsterdam, Netherlands Background: The digital era has granted us new techniques like photoplethysmogram or ECG-based wearable devices, that can remotely monitor physiological parameters of pat...
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PMC11502327
Among many drug delivery strategies, the nanoscale drug delivery system is a drug synergist that has emerged in recent years.
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PMC11267830
From the inside out, the first ring arranges differential proteins clockwise according to their P values from smallest to largest.
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PMC11538390
Two-sided P values are obtained from a likelihood ratio test in regression analysis and are not corrected for multiple comparisons.
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PMC11335267
this peptide did not affect wild type animals but transiently stimulated feeding in Alx3-deficient mice during the first three hours after treatment (Fig. 8E).
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PMC11739504
Kat2b was revealed to interact with α-tubulin endogenously and regulate its acetylation level in a Kat2b-dependent manner.
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PMC11626627
These experiments demonstrated that TWIST1, as a downstream target of circATP2B1/miR-204–3p axis, plays a crucial role in regulation of migration and invasion in ccRCC.Fig.
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PMC9429973
In vivo, iron supplementation reduced the amount of MEC-1 cells in bone marrow and spleen of xenograft mice as compared to control saline-treated mice.
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PMC10820104
Compounds rubrumline P (1) and neoechinulin D (4) confirmed preferential cytotoxic activity against PANC-1 cancer cells with IC50 values of 25.8 and 23.4 µM, respectively.
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PMC11633763
Thereafter, the cells were incubated with 2 μL of the first antibody overnight at 4°C, followed by centrifugation to collect agarose beads.
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PMC7433824
We presume that this increase reflects a self‐defense mechanism of cells against metabolic stress, as HSP7C is a molecular chaperone protein which expression is triggered in squamous cell carcinomas when they become resistant to cisplatin.
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PMC11767817
Chemiluminescence detection was performed using the biotin–streptavidin–horseradish peroxidase method and analyzed using the Invitrogen iBright system (Thermo Fisher, Waltham, MA, USA).
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PMC5916734
Normal processing of FIX propeptide can be restored upon coexpression of subtilisin/kexin-like convertase PACE/ furin or convertase PC5 homologous to it.
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PMC7081114
However, KIF21B expression did not correlate with gender, age, tumor size, or alpha fetoprotein (AFP) level (P > 0.
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PMC11533140
The method is shown in Scheme 2.
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PMC11767793
The absorbance was recorded at 490 nm using a Synergy 5 plate reader (BioTek, Winoski, VT, USA).
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PMC11697189
The annotations below the waterfall chart indicate different mutation types represented by different colors (B) The CNV variation frequency of gain and lost for HSP genes in TCGA cohort.
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PMC9268620
Some in the later stages showed the collapse of chromatin into two or more spherical masses.
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PMC9856122
Similar research performed on the same cell culture model along with transcriptome analysis showed the potential of CEP in inhibiting viruses through various pathways including cellular stress responses and autophagy .
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PMC11551844
The forms (i.e. stars, nanospheres, nanorods, nanotriangles, nanocubes, nanobranches and nanobipyramids), charge and size of AuNPs are important to address cancer.
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PMC11513011
DIB treatment also inhibited tumor growth in vivo in all three cell lines.
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PMC8996378
The study on structure activity relationship (SAR) showed the importance of substitution on medium-size rings (carbons 8, 9, 14 and 15) (Corea et al., 2004).
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PMC11612794
Two binding regions of CENP-T are required for the chicken CENP-T-Mis12C interaction (A) The magnified view of the Nsl1 acidic surface associated with the binding region 1 of CENP-T. Left: The transparent surface model of Mis12C is overlaid on a cartoon model.
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PMC10988555
A2780 cells were exposed to 10× IC50 concentrations of the complexes for 12 h and the cell fractioning kit was used to obtain the cytosolic, mitochondrial, and the nuclear fractions (Table 3).
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PMC11252033
Furthermore, these experiments highlight that the inhibition of CryZ binding on the Bcl-2 and Bcl-xl mRNAs by ASA has a fundamental relevance in increasing sensitivity in the A2780S cell line and in reversing resistance in the A2780R cell line.
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PMC10955424
Consistent with clinical observations, the effect of dasatinib's as a single agent has a limited effect in patients with recurrent OC .
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PMC11576293
Moreover, substituents affected tested compounds’ measured lipophilicity parameter (RMo) values.
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PMC11593031
However, ATCC clearly states for Neuro-2a that “this tumor line, designated C1300, was obtained from the Jackson Laboratory, Bar Harbor, Maine” .
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PMC11515150
Raji cell line was used as negative control without expression of CD5, while the cell lines of T cell leukemia Jurkat and CCRF-CEM, the cell lines of MCL Jeko-1 and CD5 Raji were used as target cell lines (Fig.S2a-c).
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PMC9429973
Two patients were assigned to two different clusters and defined as genetically composite.
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PMC11541409
Deletion in exon 11 creates a TKD conformation, which permits imatinib entry.
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PMC9429973
While there was no difference between the two groups in terms of neurotoxicity, more nephrotoxicity developed in patients using tacrolimus (p=0.013).
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PMC9672323
To this end, PBMCs were treated with two concentrations of piroxicam (3 and 30 µM) and dexamethasone (0.1 and 1 µM) either in stimulated or non-stimulated conditions.
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PMC10849234
While it has partial basal localization to the plasma membrane, its abundance at the membrane increases upon secretion of these vesicles .
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PMC11700340
Moreover, breast cancer cells exhibit a higher abundance of Hsp90 than normal cells.
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PMC11637276
CDMs were then washed with PBS and stored at 4°C in PBS supplemented with 1% Penicillin/Streptomycin.
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PMC10926885
Furthermore, COX regression analysis revealed that increased NDE1 expression negatively impacted the overall survival (OS) of the GBMLGG, LGG, LAML, KIPAN, LIHC, BLCA, MESO, PAAD, LAML, ACC and KICH.
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PMC11767725
Pro-Inflammatory Signaling Pathways : oPro-inflammatory adipokines and cytokines, including TNF-α and IL-6, activate key signaling pathways: NF-κB and JAK/STAT.oThese pathways disrupt insulin signaling, alter macrophage polarization, and impair endothelial function, creating a feedback loop that perpetuates metabolic a...
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PMC11730305
Also, the absorption wavelengths of 1611, 2933 and 3448 cm are related to N-H, C-H, and OH bonds, respectively (Fig. 2).
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PMC11365427
In the orthotopic transplantation model, luciferase-transfected RPMI-8226 cells were intravenously injected into NOG mice.
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PMC11488203
Finally, miR-210-3p expression also inhibits growth and metastatic spreading of bladder cancer .
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