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OTAR3088
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BioData-CellLine_annotated

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PMC11765879
To evaluate the cytotoxic effect of both compounds in combination against HER2-positive breast cancer, ZR-75-1 and SK-BR-3 cell lines were treated with gradually increasing concentrations of each compound.
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PMC9429973
The transcriptional profile of tumor tissue biopsies was highly conserved in lymphomoids, indicating that we are able to maintain the tissue heterogeneity present in the original tumors.
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PMC10568263
The crystal structure of MoO3 nanosheets exhibited an orthorhombic phase (JCPDS card no. 05-0508).
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PMC11755519
The mRNA levels of IL-10 and TGF-β were significantly upregulated in exosome-treated macrophages compared with control macrophages.
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PMC11770199
For A375 cells, Ctrl versus p14 in 4 genes, ***P < 0.001. (
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PMC11261875
For details, please refer to sections from Glucose transporter (GLUT) to Biomarkers.
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PMC11610461
Notably, PSENEN expression was positively correlated with regulatory T cell infiltration levels in our immune infiltration results.
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PMC9014716
The results preliminarily confirmed that miR-224-5p can down-regulate P-gp by modulating ABCB1 mRNA levels.
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PMC10840195
Then, the markers of proliferation, migration and invasion PCNA, Ki-67, MMP2 and MMP9 also showed the same results (Fig. 5E).
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PMC11533140
Overexpression and mutations in class I PI3Ks have been identified in tumors such as lymphoma, prostate cancer, and gastric cancer (De Santis et al., 2019).
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PMC10809689
RP-HPLC Method, OPA/MPA precolumn derivatization using fluorescence detector excitation 350 nm and emission 450 nm wavelengths.
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PMC11335267
Expression of receptor genes in the arcuate nucleus of wild type or Alx3-deficient mice fed ad libitum.
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PMC11730320
B Read depth based on genome sequencing read alignment, with the coordinates of the first base with the drop in sequence depth corresponding to the deletion, incorrectly suggesting that the ACTT microhomology sequence (purple box) is not deleted at either deletion breakpoint.
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PMC11637284
Right, immunoblot of the pulldown experiment.
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PMC9429973
At a dose of 6 mg, the AUClast and Cmax were approximately 1.9 times higher on day 15 than day 1.
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PMC8633974
Virus was reduced in all transmitted founder strains by 82 and 94% after CRISPR TatDE transfection or lentivirus treatments, respectively.
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PMC11750712
SAS 9.4 was used for clinical data analysis.
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PMC11575040
The BRAF mutation status was obtained from the cBioPortal database.
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PMC11201245
The dried pellet is dissolved in 50 µL hybridization mix (2×SSC, 50% formamide, 10% dextran sulphate, 1% Tween 20, and pH 7.0) .
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PMC11055323
For instance, RAS becomes oncogenic through V12 point mutation .
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PMC11674441
Another study showed that the changes in the TCR repertoire differ depending on the method of vaccine, such as the TCR changing to polyclonal in the case of peptide-pulsed dendritic cell vaccines and the TCR clone becoming monoclonal in the case of peptide vaccines alone .
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PMC11188874
Proteasome ChT-like activity was determined using LLVY-R110.
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PMC11052306
In all cases, the copper complexes at 1 µM were more active than the non-complexed dendrimers at the same concentration, but the type of ligand played a crucial role.
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PMC11489275
Model 3 adjusted for age, gender, duration, smoke, RP-ILD, mechanic hand, heliotrope rash, Gottron’s sign/papules, V sigh, shawl sign, periungual erythema, Raynaud phenomenon, skin ulcer, muscle weakness, arthritis, Ro52, fever, ANA, RF, ALB, ALT, AST, CK, LDH, CRP, ESR, WBC Although previous studies have reported the ...
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PMC11756907
The lipophilic structure of the graphene carrier enables more efficient interaction of the 2-ME-graphene complex with lipid membranes and, consequently, more efficient penetration into the cell interior, compared to the isolated 2-ME molecule.
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PMC11186948
Data obtained from western blot, performed in seven biological and a minimum of two technical replicates, were analyzed by Image Lab Software (Bio-Rad) and expressed as ratio between values from protein of interest (HDAC2, H3ac or p53) and reference protein (GAPDH or H3).
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PMC9429973
UVEA-IXA is a multicenter, longitudinal, retrospective cohort study of 309 RRMM pts receiving ixazomib (IXA)-based therapy via an early-access program in Europe.
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PMC11648299
A molecular link between DD and cutaneous melanoma (CM) has not been extensively explored, yet endoplasmic reticulum stress, which is heightened in DD patients, has been suggested as a potential connection to the pathophysiology of melanoma .
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PMC11706491
Conversely, analysis of the cdc25-22 strain showed a cell cycle length prolonged by 43.57 min exclusively attributable to an extended G2 phase (156.87 min versus 107.23 min in the wild type) (Fig 2C and S3 Movie).
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PMC10975211
The search for novel antimicrobial medications has become increasingly urgent due to the growing problem of microbial resistance to conventional antibiotics.
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PMC11650848
The primers and sequences examined are shown in Fig. 4A.
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PMC7305184
Trypsin was inactivated by addition of fresh complete HAM F-12.
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PMC6160470
Statistical calculations were performed in GraphPad Prism and generation of graphics in Excel and Adobe Illustrator CS2 (NS – non-significant; *p < 0.05, **p < 0.01 and ***p < 0.001).
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PMC11087055
TUNEL assay showed that the aphidicolin-treatment slightly increased apoptotic rate but there was no significant difference between these embryos and controls (control sham, 10.6 ± 3.5%; aphidicolin, 12.1 ± 3.7%, p=0.20, n=4 for each, Figure 2—figure supplement 2B), suggesting that the bilateral rotating cell flow in t...
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PMC10965315
The results of the study suggest that harmaline attenuated the growth of A2780 cells by inducing apoptosis and cell arrest.
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PMC10421378
An important aspect of adhesion is the competitive exclusion of pathogens.
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PMC11747949
CCR2 inhibition did not have significant effects on CXCR1 expression (Figure 2F).
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PMC9429973
The MSC-ITP-C+ group showed fewer iTr35 subsets (P<0.05) in BM than the MSC-ITP-C- group and healthy donors (MSC-Control group).
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PMC8358006
The BigWig file was then submitted to IGV to visualize RNA-seq signal at individual genes.
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PMC8193046
This can also be visualized when comparing the initial hit rate for multitarget ABCB1, ABCC1, and ABCG2 inhibition of the virtual screening data set (23.5%) with the hit rate of 40% found in the presented work, which indicates that C@PA_1.2 is an even more powerful methodology for the prediction of broad-spectrum ABCB1...
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PMC9031474
Although more than 200 compounds derived from natural products are currently in preclinical and clinical investigations only a few of them will be used in clinical routines in the future.
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PMC9429973
Overall,the severe toxicities are manageable.
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PMC11468365
First, the subnetwork is learned to extract the features of the cell line.
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PMC7334607
Figure 1Overview of Experimental Evolution of Resistance in Ewing’s Sarcoma Cell LinesAs cells recovered from each exposure, cells were tested for their sensitivity to a panel of drugs and samples were frozen for potential use in RNA sequencing.
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PMC3164356
The two most abundant sialic acids are Neu5Ac and Neu5Gc.
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PMC9739791
In both cases, within 120 min of irradiation (400 nm, 5 mW/cm) the long-wavelength shoulder at 443 nm disappeared, indicating a release of oxaliplatin from the polymer.
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PMC6267596
Quantity was assessed with an Illumina Universal Adaptor-specific qPCR kit from Kapa Biosystems (Kapa Library Quantification kit for Illumina NGS – Catalog # KK4824 / KAPA Library Quantification Technical Guide - AUG2014).
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PMC8068766
In contrast, the pathways enriched in lists with negative DEG scores (DEG scores < 1) indicated a lower activity in HepG2-2.2.15 cells in response to Se-deficiency compared to HepG2.
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PMC8557138
Tumor endothelial cells are also known to overexpress phosphoglycerate dehydrogenase, the regulatory enzyme of the de novo biosynthetic pathway of serine, cysteine, and glycine which is involved in nucleotide biosynthesis (Falkenberg et al. 2019).
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PMC11637276
Plates containing adhered cells were washed once with PBS and 500 μl of Solution A+B was added on top of each well, 500 μl of Optimem was added and cells were incubated for a period of 4 to 6 h. After this time, the media was aspirated and 2 ml of fresh 10% DMEM was added; alternatively, for 3D spheroid generation, kno...
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PMC11470999
Melanoma's high metastatic potential, especially to the brain, poses significant challenges to patient survival.
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PMC8806312
This prognostic index could be used as an instrumental variable in the prognosis prediction of osteosarcoma.
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PMC11412721
Means ± SEM (n = 6 per genotype). (
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PMC9219615
Hs27 cells are large fibroblasts with an elongated shape, making them ideal for observing alterations in cytoskeletal organization; similarly, HeLa’s rapid proliferation and large surface area renders them optimal for observing mitotic spindle changes.
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PMC10818573
The isothermal amplification of nucleic acids using RAA has been applied in a manner similar to RPA, including in a study by Yuan Gao et al. to detect the sensitivity and specificity of RAA for detecting EBV in extracted nucleic acids.
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PMC9429973
Aims: The key secondary objective was to compare MMR rate at wk 96 on asciminib vs BOS.
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PMC8633974
The dynamic light scattering graph illustrates the size distribution of CRISPR-Cas9 encased LNPs with an average size of 180 nm (PDI=0.2). (
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PMC9429973
The incidence was again higher with Tacrolimus / Sirolimus regimen and the lowest with Tacrolimus/MMF/Ciclofosfamide-post-transplant (p-value 0.09).
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PMC11534377
Images were acquired in sequential mode across three channels with excitation at 405 nm, 488 nm, and 543 nm.
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PMC11740573
The MICs of antibiotics and calcitriol were determined using colorimetric, Resazurin-based microdilution method according to the previously described procedure .
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PMC11388384
SHH diffused as heterogenous populations through the extracellular environment. (
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PMC8633974
Data points, in e, depict mean ± SEM from triplicate biological replicates.
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PMC9429973
At baseline, 60.0% of patients had an ECOG performance status 1−2 and patients had received a median of 5 (range, 2−12) prior therapies.
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PMC9429973
No cases of VOD were reported.
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PMC11641532
Gene expression was categorized into low and high groups based on the median.
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PMC11768927
This selective viral replication, coupled with VSV’s broad tissue tropism, has spurred significant investigation of its potential in oncolytic virotherapy .
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PMC11731161
Selinexor (SEL) is the first generation of selective inhibitors of nuclear export (SINE) that has been approved for RRMM in 2019 .
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PMC11746948
In addition, 2-BP still induced ferroptosis in FSP1-KO A375 cells, indicating that 2-BP primarily targets GPX4 rather than FSP1 (Supplementary Fig. 5d, e).
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PMC9429973
HSCT had to be postponed but was successfully completed 3 months after his surgery.
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PMC9895440
Therefore, we repetitively stimulated transduced antigen-specific T cells using HLA-A2 positive T2 tumor cells loaded with 1 μM NY-ESO-1 peptides for four cycles in 3-day intervals (Tex, Fig. 1a).
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PMC9681981
Evidence suggests that CPA and CPB toxins can directly affect the cell membrane, leading to increased membrane permeability and disrupting the ionic balance in target cells.
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PMC11380454
We have previously shown that small tellurium-containing compounds inactivate the VLA-4 integrin on malignant cells via the redox inactivation of adjacent thiols in the exofacial domain of the α4 chain of the integrin 29.
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PMC11658074
Surprisingly, AT-EVs stimulated fibroblast proliferation more rapidly than ADSC-EVs did.
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PMC11537649
Furthermore, Lnc NEAT1 is also contributed to colorectal cancer progression through mediating nuclear receptor 4A1/Wnt/β-catenin signaling pathway via miR-486-5p.
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PMC9429973
Selective transcriptional downregulation is observed with 30mg IV weekly.
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PMC11560255
Apoptosis is one of how cancer cells die through programmed cell death.
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PMC11451829
The goal of this investigation was to establish a standardized preclinical model of pterygium-like lesion.
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PMC11665584
PITX1 expression induced keratinocyte activation in both healthy and wound-adjacent epidermis (evidenced by Krt6a, Krt16, S100a8, Dsc2, and Aldh1a3 expression).
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PMC10452486
Morales et al. observed the dimerization of B2m-free HLA-G (Face-3) in the villous cytotrophblasts.
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PMC11731614
We created an EV-reporter mouse line by crossing the commercially available CD63-GFP fl/fl mouse line with K14-Cre to create K14-CD63-GFP (KCG) mice.
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PMC11742864
Meanwhile, cancer cells affect the process of inflammation in a backward.
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PMC10957991
Mechanosensitive machineries thus enable cells within the tissues to adopt their cellular structure and rigidity as well as direct cellular functions that are essential for the normal homeostasis of the tissues.
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PMC11721096
Under these optimized conditions, the limit of detection (LOD) for quercitrin was 0.166 μM (Part S3 in Supplementary Data).
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PMC11352746
However, there has been a long-standing reliance on immortalized cell lines (such as PC-12 and SHSY-5Y) in preclinical CNS drug discovery.
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PMC11413393
Cells were washed 3 times in 0.25% Triton X-100 in PBS (PBS-T) and secondary antibodies: Goat anti-Rabbit IgG H + L -Alexa FluorTM 594 (Invitrogen #A11037, 1:400) or Goat anti-Mouse IgG (H + L) -Alexa FluorTM 488 (Invitrogen #A10667, 1:1000) was added in blocking buffer for 1 h at room temperature.
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PMC6461034
A “PhosphoSitePlus” (PSP) analysis data table is generated by: ○Merging table 3 with data from the PhosphoSitePlus Kinase_Substrate_Dataset that details experimentally observed human kinase–substrate relationships.
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PMC11655498
They serve as transcriptional activators for lytic gene expression by binding to host transcription factors and specific response elements (Urier et al., 1989; Gruffat et al., 1990; Heilmann et al., 2012).
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PMC6803987
The polyvinylidene fluoride (PVDF) membrane was incubated with a secondary antibody (goat-anti-rabbit IgG-HRP, 1:5000) at room temperature for 1.5 h, then washed with TBST five times (5 min each time).
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PMC11656048
Mechanically, shikonin inhibits the expression of xCT and GPX4 by interacting with Nrf2 and promoting the ubiquitination degradation of Nrf2, thereby leading to ferroptosis (Figure 6).
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PMC11347429
APOBEC3B (Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3B) affects type I IFN and was associated with COVID severity in African-Americans (70, 71).
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PMC9812014
Its viral RNA-genome is transformed to double-strand DNA in the infected host cell by reverse transcriptase once it enters the cell .
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PMC11759543
Doxorubicin was purchased from Hospira Australia Phy Ltd (Pfizer, Milano, Italy).
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PMC10976516
Yu et al.Myxoma virusOncolytic myxoma virus (MYXV)Intraperitoneal and intratumoral application of MYXV, single or combined with a low dose of cisplatinIntratumoral delivery of MYXV to the syngeneic immunocompetent murine SCLC model induces extensive tumor necrosis with marked host immune cell infiltration.
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PMC10040136
The findings indicate that the addition of CM can raise the IC50 of IM from 55.2 µM to 155.3 µM, which could be restored to 107.1 µM by administering a PI3K inhibitor, as shown in Fig. 6F.
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PMC10421378
Drying and coating can be utilized as a sufficient treatment, allowing a long shelf-life (up to 12 months).
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PMC11413393
Open reading frame for PRMT1v1 (ENST00000391851.8) was cloned into the Mini-Turbo plasmid via gateway cloning using pDONR223 (gift from Dr. Brian Raught’s lab) and BP/LR combined cloning reagents (Gateway BP clonase II enzyme mix, Thermo #11789020 and LR Clonase II Enzyme Mix, Thermo, # 11791019).
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PMC11266100
The cells in the electroporation buffer were mixed with YP1 stain for the final stain concentration of 1 μM. The 50 μL of mixed solution were positioned between the electrodes and subjected to various EP protocols.
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PMC8382973
The evaluation criteria were derived from the Biological evaluation of medical devices—Part 5: Test for in vitro cytotoxicity (GB/T 16886.5-2017/ISO 10993-5:2009, IDT) (35).
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PMC11310713
Biological replicates were conducted using separate populations of animals.
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PMC2614415
Caspase 3/7 assays of PTX10 (C) and 1A9 (D) cells treated with increasing doses of VE-465 demonstrate dose-dependent increase in apoptosis.
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