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OTAR3088
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BioData-CellLine_annotated

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PMC10914904
Vault (vt) RNAs are noncoding (nc) RNAs transcribed by RNA polymerase III (RNA Pol III) with 5ʹ-triphosphate (5ʹ-PPP) termini that play significant roles and are recognized by innate immune sensors, including retinoic acid-inducible protein 1 (RIG-I).
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PMC11021472
Probes used for further analyses were flagged as present by the feature extracting software in all conditions resulting in 20,838 usable probes out of a total of 58,341 probes.
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PMC9429973
We observed that response rates were significantly higher in our pediatric cohort when compared to our adult cohort.
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PMC11794588
The plant material that had completely dried out was ground into a powder, and by utilizing a technique designed by Panda et al., small-scale extraction was accomplished.
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PMC11607638
In regard to the delayed time course of blood meal intake, we are unable in the present work to actually distinguish between possible changes in the food‐probing behavior or the rate at which the female mosquitoes were satiated.
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PMC9429973
Cell morphological analysis was performed after May-Grunwald Giemsa staining.
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PMC11046454
Being a customized living drug, the expansion of CAR-T cells in response to antigen stimulation is considered a crucial factor in achieving a complete response.
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PMC11759543
The preatment of pan-caspase inhibitors could restore a recovery rate of approximately 41 % in 5637 cells and 42 % in BFTC 905 cells.
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PMC11420784
B, Bacterial exocytosis into HBSS buffer after 6 hours of incubation with WT, ΔpldA, or ΔpldA+ infected mouse bladders pretreated with or without 3-MA, n = 9.
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PMC11248911
The selected derivative interacted with the target protein revealing the structural requirements for activity of potent APN inhibitors, the presence of the heterocyclic scaffold, having the sulfur atom involved in coordination of the zinc ion, is usually favored for formation of the desired interactions.
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PMC11791478
Graph shows mean and SD of quadruplicate wells.
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PMC5308810
However, further studies are required to investigate the role of CXCR4 or its associated SDF-1/CXCR4 axis to regulate ABCB1 or vice versa.
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PMC11470999
As expected, CIP2A knockdown significantly reduced the proliferation of B16 and A375 cells (Figure 4D).
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PMC5417661
Samples were taken from the donor and receiver chambers at 120 min.
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PMC11075223
Oral ulcer powder significantly improved the symptoms of ulcer in rats.
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PMC11727638
In contrast, CD20 expression on KML-1 cells cultured for 2, 7, and 10 days in the Cell Domes showed one peak and gradually decreased with increasing culture periods (Figure 6a and Table S2, n = 3, p * < 0.05).
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PMC9429973
Those with high-risk disease features started blinatumomab after 2 cycles of hyper-CVAD.
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PMC6901583
The CCK8 assay showed that the cells expressing BRD4 showed higher growth patterns than those expressing control vector (Fig. 2b).
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PMC11701801
B, Volume of tumor xenografts derived from SS18–SSX fusion Fuji cell lines and harvested from mice treated once daily with 30 mg/kg CP-C27.
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PMC11525028
Cells were treated with actinomycin D (MCE) for 0 h, 3 h, 6 h and 12 h, followed by RNA extraction as described above.
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PMC11721277
Additionally, the complex 5,10,15,20-tetrakis(2,4,6-trimethoxyphenyl)porphyrin (Ga-TTMPP) exhibited specific localization in the fibrosarcoma tumor region and also showed high tumor-to-muscle ratios.
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PMC11411004
We found that I-4 had a significant inhibitory effect on the protein expression of LSD1 and that it up-regulated the protein expression levels of H3K4me2, Ac-H3K9, and Ac-H3K27 in cells (Fig. 5a, b).
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PMC9429973
Results: Overall 112 patients (45 women and 67 men) with diagnosed gastrointestinal and chronic liver disorders complicated by IDA or ACD were included in the study.
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PMC10547921
The authors have no conflicts of interest to declare.
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PMC11612315
One-way ANOVA followed by Dunnett’s multiple comparison test (ns, not significant; ****p < 0.0001, compared with the control, pH 5.5).
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PMC11352311
Network pharmacology, an emerging multidisciplinary research method, offers innovative approaches for studying natural product medicine.
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PMC11472639
Thus, the strong effect size observed herein may still have important clinical implications for patients in myeloma remission.
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PMC4369959
Besides these, Asian ginger component zerumbone modulates NF-κB, p53 VEGF, p21, and CXCR4 expression.
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PMC11507371
More precisely, several studies have shown efficient partial remissions after treatment of various cancers such as breast and bladder cancer, as well as malignant melanoma in vitro and head and neck cancer in vivo .
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PMC11463018
The piperonyl of 19 occupied an external cleft created by His500 and Ser568 at the surface of HDAC6 protein.
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PMC10706275
The proteins were moved from the gel to an NC membrane for 70 min at 110 V. Subsequently, the NC membrane was air-dried and blocked for one hour at room temperature with 5% skim milk.
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PMC10747139
Santi et al. (2021) (Table 2) studied the activity of Ru(II) η–arene compounds using 3D models of head and neck squamous carcinoma cells (HNSCCs) with or without human papilloma virus (HPV) infection compared with RAPTA-C. Human squamous cell carcinomas SCC-25 (HPV-negative, HPV−) and UPCI-SCC-154 (HPV-positive, HPV+) ...
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PMC11055323
n = 3 independent experiments.
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PMC11680982
ZR-75-1 cells were cultured in RPMI 1640 supplemented with 10% fetal bovine serum and 100 units/ml penicillin and streptomycin.
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PMC9504875
Whether other viral proteins, including N and G proteins, are involved in IFN production remains unknown.
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PMC11774251
Venn diagram illustrating the number of differentially expressed genes between Tan-I vs Con (313 genes) and Con vs NC (1653 genes), with 181 genes overlapping. (
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PMC11351758
In isolated mitochondria, the opening of the MPT pore leads to the collapse of the electrochemical gradient of H, i.e., causing mitochondrial membrane potential depolarization, thereby annihilating the driving force needed for ATP production and triggering the production of ROS.
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PMC11088135
A, B The mRNA and protein level of YAP1 in U251 cells transfected with NUTM2A-AS1-siRNA or control-siRNA was determined using qRT-PCR and western blot assay.
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PMC9621239
Accordingly, these predominant haplotypes were speculated to be localized in the liver tumour microenvironment and potentially conducive to the formation and maintenance of the liver tumour microenvironment.
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PMC11119602
Unlike measurements made directly on cells grown on plates, scratch test migration assays indicated that the initial growth rate of cisplatin-resistant cells was approximately 60% faster than that of parental cells (Figure 1G).
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PMC11680578
Effect of paclitaxel (PTX) and rosiglitazone (RGZ) on the nuclear fragmentation of SKOV-3 ovarian cancer cells. (
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PMC11543935
The HE staining of the sample treated by the STIMULATE device with 1000 V/cm, 8 pulses and 25 cycles is shown in Fig. 5C.
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PMC11770130
This common feature of GPCR highlights the significance of studying the NTS-NTSR2 signaling in various cell types specifically.
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PMC11596967
Peptide samples were prepared in phosphate-buffered saline (PBS) and aliquoted into a 96-well plate at 10 µL per well.
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PMC11656657
An additional retroviral vector encoding eGFP-Firefly-Luciferase (GFP-FF-Luc) was used in selected experiments to label tumor cells for in vitro and in vivo studies.
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PMC11461833
Jona in 1886.
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PMC2196094
These probes have been used as specific tools to estimate mRNA frequencies for the different proteases in normal freshly isolated peritoneal MCs.
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PMC11680982
combined with endocrine therapy (fulvestrant, 100 mg/kg, i.m.)
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PMC11787355
All animal procedures were conducted in compliance with the institutional laboratory animal research guidelines and were approved by the governmental institutions (Regional Administrative Authority Karlsruhe, Germany, file numbers: G-263/18 and G-130/23).
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PMC10669966
No. 353377, CORNING, Corning, NY, USA) and allowed to attach for 24 h before the addition of drugs.
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PMC11706776
Wilcoxon tests were used during cell cycle assays.
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PMC6799808
Similarly, GLPT also inhibited the phosphorylation of Akt (T308) (Fig. 4b), which is mediated by PDK1 (phosphoinositide-dependent kinase 1).
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PMC10914904
IκB phosphorylation promotes the translocation of NF-κB into the nucleus, where it induces type I IFN and proinflammatory responses ; however, the activation of NF-κB has been associated with several aspects of oncogenesis, such as stimulating cancer cell proliferation, apoptosis resistance during drug treatment, and t...
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PMC11770746
We and others have demonstrated that multitargeting Pt(IV) prodrugs, formed by conjugating bioactive axial ligands such as enzyme inhibitors or FDA-approved drugs to the axial positions, can simultaneously deliver to the tumor two or three bioactive moieties that act synergistically to kill cancer cells and overcome dr...
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PMC9429973
We conducted a survey project for generation of local data on SCD, to deeper understanding disease burden, patient journey treatment pathways and QoL and get insights on SCD epidemiology on national level, in our country Aims: The study answered the following main research question: What is the frequency (number per ye...
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PMC11742290
Wang, J. (2024) https://BioRender.com/e54f457 LGR5 Structure. (
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PMC11252553
Treatment of the samples with Taurine leads to a decrease in the percentage of apoptotic lymphocytes at both time points, which is more pronounced at 48 hours post-irradiation compared to 72 hours for all three doses.
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PMC9429973
ROCKi induced mitotic catastrophe (G2M arrest and multipolar spindles) through their apparent effects on microtubules and nuclear organization, and leading to cell death.
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PMC9429973
Patient demographics/clinical characteristics, real-world objective response rate, overall survival, progression-free survival, healthcare cost, and resource utilization will be assessed as secondary endpoints.
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PMC7685376
MCM4/6/7 has helicase activity and DNA-dependent ATPase activity, which is the catalytic core of MCM complexes.
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PMC11788920
Targeting the NTS with dCas9 stabilizes the GQ structure, which further strengthens the blockade effect and suppression of transcription.
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PMC9111184
For instance, it is known that EZ, drug used to treat hypercholesterolemia, inhibits Niemann-Pick C1-like 1 (NPC1L1) and mediates cellular cholesterol uptake (Feng et al., 2017; Nakano et al., 2020).
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PMC11777207
B16.F10 melanoma cells were cultured in DMEM (Corning) and supplemented with 10% FBS, penicillin-streptomycin, sodium pyruvate, Hepes, NEAA, and 2-mercaptoethanol.
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PMC7022782
Further, in vivo studies are required to confirm the real potential of this formulation.
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PMC11377827
qPCR of USP43, CA9, HIF-1α, or HIF-2α in control or USP43 depleted HeLa cells following incubation in 1 or 21% oxygen for 16 h. n = 4 biologically independent samples, mean ± sd.
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PMC11240448
We observed a large variance in the accuracy when , and found that the accuracy depends on which analytes to select.
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PMC9429973
Results: High SET gene expression in patients was found to be significantly associated with advanced disease phase and worse clinical and laboratory findings while low expression was significantly associated with better molecular response assessed by BCR-ABL1 level.
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PMC5034105
The findings in our study help to explain the viral shedding pattern, transmission and pathogenesis of the rapidly disseminating ZIKV, and are useful for optimizing laboratory diagnostics and studies on the pathogenesis and counter-measures of ZIKV.Zika virus (ZIKV) is a mosquito-borne flavivirus that has been largely ...
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PMC2614415
We used immunocytochemistry to determine the percentage of cells positive for histone H3 phosphorylated on Serine 10 (pH3S10) after treatment with VE-465.
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PMC10882807
Construction of an ROC curve for HCC patients based on hsa_circ_0005397 expression. (
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PMC9429973
A. Schirripa, M. Prchal-Murphy, R. Grausenburger, K. Kollmann, V. Sexl Veterinärmedizinische Universität Wien, Vienna, Austria Background: Cell-cycle progression is governed by regulatory proteins including cyclin-dependent kinases (CDKs), cyclins and CDK inhibitors.
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PMC11420784
Intracellular bacteria have evolved many strategies to cope with degradation by autophagy .
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PMC11334037
GIST cells with IGF2 knockdown were sensitive to imatinib treatment when IGF2 overexpression significantly raised imatinib resistance.
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PMC7022782
The antitumor activity previously described for PECA-NPs could be moreover exploited, maybe as a synergic effect of loaded anticancer drugs, to support the surgical removal of tumor lesions.
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PMC11700340
Cancer cells were subjected to a 1000 µg/ml concentration of linagliptin for 72 hours. (
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PMC9776316
SP600125 (Selleckchem; Cat.
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PMC11612794
This structure is similar to the crystal structures of human and yeast Mis12C.
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PMC11015054
Concerning the influence of METTL5 expression on the overall survival rate of HCC patients, analyses of Kaplan–Meier survival and multivariate Cox survival were conducted, which demonstrated that overexpression of METTL5 predicted an unfavorable prognosis.
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PMC9429973
No differentiation syndrome was observed.
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PMC10093184
Data represent the mean from six replicates.
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PMC10669128
In this regard, Hemming and colleagues characterized LMS PDX models assessing that, across multiple xenograft passages, the parental tumor histological appearance, copy number variation, and transcriptional program were maintained.
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PMC9429973
Results: The study included 368 patients (CLL n=205, 55.7%; NHL n=163, 44.3%) treated with targeted drugs (Table 1).
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PMC11392912
Earlier, the absorption of plant miRNA in the human body and the validation of their role in human gene regulation have been reported .
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PMC7602170
The overexpression of constitutively active mutated S6K1 or wt eIF4E accelerated G1-phase progression, suggesting that S6K1 and 4E-BP1/eIF4E as downstream signals of mTOR, regulates cell proliferation to a certain extent by controlling the cell cycle .
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PMC9509578
Therefore, inactivation and detoxification of chemotherapeutic drugs by human cytochrome P450s (CPY) phase I and/or II enzymes can contribute to the development of cancer MDR .
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PMC9429973
HDAC6 was upregulated and decreases the acetylation of FOXO1, further repressing autophagy.
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PMC11377827
Input samples were taken at this point.
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PMC5311252
These methods are currently reaching sufficient analytical depth and throughput to be integrated in systems biology analysis as shown by us and others, and will certainly further improve our knowledge of cancer biology.
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PMC10114490
B mRNA levels of multiple hepatic gens in diHLC-T. Values correspond to the average plus standard deviation of two different experiments (four samples each) determined by RT-qPCR and expressed relative to adult human liver (pooled RNA from 3 donors).
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PMC9581083
M. alba L. leaves can treat headache, dizziness, cough, bronchitis, asthma, and eye infection (DeFilipps and Krupnick, 2018).
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PMC11658074
These findings suggest that CD151 can promote the internalization of EVs by cells.
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PMC9429973
Analysis 1 is a futility assessment focused on ORR.
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PMC11434983
HPLC analysis was performed on Waters 600 system equipped with a Waters 2487 Dual λ absorbance detector and a Gabi γ-detector.
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PMC10142392
These attractive characteristics have sparked increasing interest from the scientific community in these macromolecules.
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PMC10362265
The human tetramer, which was constructed using the 7al7 heterodimer, showed particularly low mobility compared to the heterodimer form (Fig. 2b).
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PMC11371747
50% inhibition of [H]-l-LV influx by PLX and MTX was noted at 2.5-fold lower and 3-fold higher concentrations than l-LV, respectively (Figure 3).
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PMC11089031
This is a limitation of this study.
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PMC3931643
These results suggest that asTORi treatment in the VAL cells is ineffective at inhibiting the formation of the eIF4F translation initiation complex.
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PMC9429973
Median age was 52.9 (range, 3.2–81.5) years, 44.4%/47.2% of pts were high/intermediate risk per PTLD-adapted prognostic index, and median number of lines of prior systemic treatment was 1 (range, 1–5).
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PMC11252033
In all cases, after 48-h of drugs or siRNA-drug exposure, cells were fixed with 10% trichloroacetic acid and stained with 0.4% SRB in 1% acetic acid.
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