Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC5810978
Semi-confluent Caco-2 and Vero cells grown in four 24-well plates (total 96 wells) were infected with a genetically modified amphotropic retrovirus containing a human small intestine cDNA library and the G418 resistance gene (Clontech-Takara Custom Service) at multiplicity of infection of 1.0 for Caco-2 cells, and 0.1 ...
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PMC9878562
Transcript levels of the lipoxygenases ALOX5 and ALOX5AP, the hydrolase LTA4H and the LTB4 receptors BLT1R and BLT2R of VAL-wt and VAL-ko (means ± SD, Šídák multiple comparison, 2way ANOVA ns p≥0.05, *p ≤ 0.05, ****p ≤ 0.0001) ns (not significant).
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PMC10114490
Cellular MMP was defined as the TMRM fluorescence intensity in punctuate cytosolic regions around the nucleus.
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PMC11748618
Genome-wide association studies identify genomic regions associated with a particular phenotype, but do not inherently provide information on causal variants or functional consequences.
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PMC11786600
This study, kaempferol was selected as a natural compound component of the dressing.
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PMC11463018
The cavity occupied by TSA or Filgotinib was selected as the binding site.
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PMC11477621
To a solution of 2-acetyl pyrrole (196 mg, 1.80 mmol) in dry toluene (15 mL) was added potassium hydroxide (61 mg, 1.09 mmol) and 18-crown-6 (79 mg, 0.30 mmol).
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PMC11413393
To confirm the functional importance of each type I PRMT enzyme for proliferation and viability, we employed a CRISPR-Cas9, GFP-drop out methodology (adapted from Lin et al.; Fig. 2b).Fig.
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PMC11626627
Potential binding sites of miR-204–3p on the TWIST1 mRNA 3′UTR analyzed using Targetscan (https://www.targetscan.org/vert_80/).
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PMC11297139
Statistical analysis performed using a two-tailed Wilcoxon signed rank test on day 4 samples of ARID1A + WT, and ARID1A + ΔDD A673 cell lines.
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PMC10329074
YBX3, also known as DNA binding protein A (DBPA), zonula occludens 1-associated nucleic acid binding protein (ZONAB), or cold shock domain protein A (CSDA), was an epithelial-specific transcription factor that is ubiquitously expressed in various cell types.
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PMC9429973
Unacceptable response to SC, progressive disease and patient choice were common reasons for not going on to receive SCT.
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PMC11665555
Therefore, targeting OXCT1 can be beneficial for gemcitabine sensitization, not only by restricting energy and nucleotide precursors (required for DNA repair) but also by promoting epithelial cell fate through OVOL1 activity.
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PMC9341513
Crucially, HiP-HoP does not use Hi-C (or any other 3D genome data) as an input (unlike other popular models which use fitting-based methods) (Serra et al. 2015).
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PMC11791432
It was identified as a novel diagnostic marker for cholangiocarcinoma .
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PMC2614416
Ontologies found in this mapping are much less – almost half of the number found previously in Figure 1 (Panels A and B).
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PMC9429973
It is possible to discriminate between IDA and TT by routine complete blood count (CBC), hemoglobin (Hb) electrophoresis and iron parameters; however, it is very difficult to distinguish IRIDA from IDA and TT using only routine CBC and iron parameters.
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PMC8735881
We next characterized the inhibitory capacity of GPI-scFvs on HIV-1 Env-mediated cell–cell fusion by a DSP-based cell fusion assay, in which HEK293T cells were transfected with a viral Env-expressing plasmid and a DSP1-7-expressing plasmid as effector cells, while 293FT cells stably expressing CCR5/CXCR4/DSP8-11 were t...
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PMC9429973
And achieving deep remission (≥VGPR) in the first-line therapy predicts the best prognosis regardless of response rate.
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PMC11740573
It is well known that vitamin D deficiency is associated with various diseases like diabetes, cancers, or autoimmune diseases.
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PMC9429973
Median follow up was 48.4, 46.0,40.5 and 35.2 months, respectively.
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PMC11754094
f, The effect of ART558 (POLQ inhibitor) in reducing large-deletion events mediated by CGBE1 in HeLa cells measured by long-range amplicon sequencing (n = 3, mean ± s.e.m.).
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PMC11678841
This important finding, once again, demonstrates the potential of GA as a natural agent and modulator of the innate immunity response to the host, studied in different experimental models, including exposure to bacterial components, such as LPS , and SARS-CoV-2 infection .
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PMC8345486
Nucleoside modification with cobalta bis(dicarbollide) did not significantly alter the toxicity against both SKOV-3 and OVCAR-3 cells with respect to the unmodified metallacarborane (compound 1), regardless of whether the metallacarborane was toxic to cells (SKOV-3) or not (OVCAR-3, Figure 2B).
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PMC9429973
Moreover, in gram negative organisms, Acinetobacter species, Burkholderia cepacia, Citrobacter species and Moraxella Species were identified substantially which were not previously previously prevalent.
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PMC10530622
The primary focus of managing PH is to decrease the excretion of urinary CaOx in order to extend kidney function, delay the progression to ESKD, and minimize associated complications.
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PMC9429973
NGS was performed with bone marrow aspiration samples taken at the time of diagnosis by the Molecular Pathology unit.
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PMC11402217
In summary, our experimental data compellingly suggest that XD23 impedes the invasive and migratory tendencies of OS cells by regulating their EMT differentiation.
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PMC8740518
In this study, we found that citrate levels were significantly decreased in the cancer model group compared to the control group.
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PMC11381192
In the present study, we developed and validated an integrated cellular stress index (CSI) to predict survival outcomes for MM patients.
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PMC8526701
The cell lines GIST-882 and GIST-T1 were obtained from the Shanghai Institute of Biological Science (Shanghai, China) and were grown in RPMI-1640 medium (Gibco, USA) supplemented with 10% fetal bovine serum (FBS; Gibco, USA) and 1% l-glutamine (Gibco, USA) in 5% CO2 at 37 °C.
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PMC10033453
Phase and red fluorescence images of the A673 cell line were taken every 3 h for a total of 72 h after introducing the virus, and the red area was used to quantify the relative level of apoptosis per viewing field at each time point.
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PMC10092581
The cytotoxicity was assessed by the MTT test.
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PMC11409031
Fig. 2HdWGCNA shows that turquoise, pink, yellow, red, blue, black, and green modules are seven central modules closely related to T cell subsets in OV. (
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PMC11519077
Recent research indicates that mesenchymal stem cells (MSCs), known for their anti-inflammatory and anti-infectious properties, could be a promising alternative for treating inflammatory diseases such as inflammatory bowel disease (IBD).
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PMC10212663
Real‐time live‐cell imaging was conducted every 4 h using IncuCyte S3 (Essen BioScience; Sartorius).
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PMC9817179
D–F) Quantification of LLPS parameters after fixation.
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PMC11615743
The excellent biostability of the L‐DNA scaffold, as well as its low binding affinity for environmental nucleic acids and proteins, helped us develop highly effective signal amplification methods for sensitive cell labeling, thereby ensuring the excellent accuracy of the devices for cell identification and isolation in...
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PMC8481254
HG levels are one of the most dangerous factors for liver cancer and a major characteristic of T2DM.
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PMC5535901
TNF-α is a pleiotropic cytokine that binds to its receptor to activate diverse downstream pathways leading to inflammation , whereas PMA/ionomycin has been widely used for studies related to T-cell activation and dissecting the TCR pathway.
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PMC6643347
It should be noted that an elemental analysis of humic substances isolated from the same source using the same isolation and fractionation methods yields reproducible results.
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PMC11621565
LPS 1 µg/ml caused a mean increase of 1.28 times compared to the control but without statistical significance.
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PMC6379402
An annotation is considered to be statistically significantly enriched if its enrichment p value, after correction for multiple hypothesis testing, is lower than or equal to 5%.
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PMC8143558
There could be an interaction between the extraction solvent and the type of plant.
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PMC8750422
To further determine whether downregulation of GPR87 inhibited cell proliferation and invasion in lung adenocarcinoma, we performed invasion and proliferation assays in GPR87-silenced lung adenocarcinoma cells (Figure 1d and Figure S1c,d).
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PMC11487720
Also, MDA-MB-231 (NH) and metastatic MDA-MB-231 (IV2-3) cells were from the National Health Research Institute, Taiwan.
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PMC4112127
However, comprehensive studies for DNA methylation as a biomarker and mechanism for regulation of gene expression in CC have been lacking until recently.
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PMC11585565
However, at 48 h, the mean levels of FLAG-tagged p.(Gly492Cys) and p.(Gly492Asp) proteins were significantly decreased compared with that of WT by 10.5-fold and 5.8-fold, respectively.
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PMC9429973
Univariate analysis revealed that a high EASIX-1year value was significantly associated with both late NRM and late OS (5-year NRM 10.1% vs. 1.3%, p<0.05, 5-year OS 88.7% vs. 95.1%, p 0.05).
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PMC10454535
Downregulation of these antioxidant enzymes by PIN/BTZ sensitizes MM cells to oxidative stress, especially considering MM cells have increased ROS levels compared to normal plasma cells .
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PMC11779876
Malignant cells were defined by the presence of at least one clonotypic CDR3 sequence and analyzed for TRBC1 or TRBC2 expression.
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PMC11301095
Differentiating PAM from other encephalitis types was initially challenging, but rapid diagnosis was achieved within 24 h through CSF mNGS, complemented by epidemiological history and disease progression.
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PMC7081114
In this study, we explored the role of KIF21B in HCC and elucidated its clinical significance.
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PMC11686380
p < 0.0001 (vs control) by one-way ANOVA and Dunnett’s post hoc test. (
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PMC3995603
Among these different constituents, we were selected the six compounds including caffeic acid, chlorogenic acid, hyperoside, isoquercitrin, isochlorogenic acid A, and scoparone.
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PMC11634027
ds alleles were recombined with FRT40A for mitotic recombination.
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PMC9429973
Our results indicate that omipalisib could suppress cell proliferation not only through PI3K-AKT-mTOR signaling but also via impairing mitochondrial biogenesis.
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PMC10588957
Comparing the results of HepG2 cell viability at 24 and 48h, DATS treatment for 48h at 20 μM (P < 0.05), 40 μM (P < 0.05), 80 μM (P < 0.05) and 160 μM (P < 0.05) reduced cell viability.
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PMC10976516
EudraCT no. 2019-001154-26Measles virusMV-NISAtezolizumabIIntratumoral injection with measles virus, expressing sodium iodide symporter (MV-NIS) for recurrent and metastatic NSCLC.
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PMC9954564
Adherence of genotypic proportions to expectations under Hardy–Weinberg equilibrium, as well as the allelic frequencies, were evaluated using PLINK v.1.9 .
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PMC7171147
c Western blot of FASN in ES2 cells cultured in either PBS or COL11A1-coated plates for 48 h and treated with Dasatinib (2 µM) for 48 h. GAPDH was used as a loading control.
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PMC5673060
122 phosphosites on 71 proteins (2.3% of the dataset) were found to be significantly upregulated (< log2 –1) in the parental A204 cells compared to the PazR cells (Fig. 2A) with up to 40% being nuclear proteins (Fig. 2B).
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PMC7153288
Prediction of putative gene clusters for secondary metabolites performed with the AntiSMASH program showed 20 putative gene clusters for secondary metabolites in the largest contig of 7,552,296 bp while the other three smaller contigs had no predicted gene cluster for secondary metabolites.
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PMC11347429
Abbreviations: African-American (AfAm), Caucasian (Caucs), Mexican American Indians (Mex_AmInd), Mexican ancestry (Mexican anc), Indian American (Indian_Am), no unambiguous assignment (admixed). (
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PMC11670407
e-f Representative images and relative quantitative analysis of invasion assays; osteosarcoma cells were transfected with siRNA or plasmid for 48 h and then treated with cisplatin (143B, 5 μM; U2OS, 10 μM) for 24 h. i-n Representative images and relative quantitative analysis of wound healing assays; osteosarcoma cells...
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PMC11422497
Moreover, miR-494-3p assumes the role of a tumor suppressor in GISTs.
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PMC10772747
Therefore, EBE may have the potential as an agent that inhibits tumor growth in breast cancer by involving the P53 signaling pathway mechanism.
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PMC5963610
We use FACS and immunofluorescence (IF) assays to detect expression and/or phosphorylation state of several molecules in these pathways.
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PMC11155445
The presence of hydroxyl and phenyl groups in compounds (122h and 122a), at ortho position was deemed responsible for the better inhibitory activity.
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PMC9429973
T. Silfverberg, H. Cherif, K. Carlson, B. Wahlin Medical Sciences, Center for Clinical Research Dalarna/Uppsala University; Medical Sciences, Uppsala University, Uppsala; Division of Hematology Dept of Medicine, Karolinska Institutet, Stockholm, Sweden Background: Early studies of COVID-19 reported high mortality rates...
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PMC7338939
Moreover, the effect of DAPT reversed after 13 days after Notch inhibition in the xenograft model.
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PMC11541409
In addition to glycolysis, other glucose-related metabolic pathways have also been reported in GIST.
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PMC11342785
C, images from a time series of the rapamycin-induced synMAP circuit from (B).
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PMC7812570
Error bars represent the means ± standard deviations (SD) of three independent experiments with triplicate samples The results above demonstrated that GPI-m36.4 could endow target cells with potent resistance to divergent HIV-1 isolates.
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PMC11188874
Cells were transfected with the indicated sgRNA, incubated for 72 hours and then treated with each HDAC6 inhibitor (1 µmol/L).
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PMC6892818
These findings underline the importance of CD40 ‘signal-quality’ on cell fate and explain the lack of pro-apoptotic effects in RCC cells previously, while confirming the tumour specificity of CD40 in epithelial cells.
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PMC10470467
Finally, an accurate nomogram was constructed with this signature and clinical traits.
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PMC9917080
In general, for astrocytes, the sigmoid curve approximating the amplitudes of Ca-responses on SeSo is located below the curve for “naked” SeNPs (Figure 1H).
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PMC9429973
Endocrine comorbidities were associated with lower HLADR+CD4+ (p=.08) and lower HLADR+PD1+CD4+ (p=.09) T cells.
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PMC9429973
The median M-protein at initiation was 34.5g/l (8-60) with bone marrow infiltration 70%, and haemoglobin 94g/l (88-107).
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PMC11754291
Following each irradiation on days 3, 5, and 7, the keratinocyte-conditioned medium (CM, CMK, or CMiK) was thawed and added at a 1X concentration to the fresh keratinocyte medium supplemented with 0.2 nM FGF2 intended for the melanocytes.
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PMC9429973
A pre-planned interim analysis was conducted after completion of stage I and is reported herein.
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PMC11740207
Furthermore, the asymmetric segregation of organelles, such as mitochondria, plays a role in cellular aging and may impact the HE.
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PMC11802929
We identified T cell populations targeting previously reported immunogenic antigens, and we find that the prediction rankings from the commonly-used NetMHCpan algorithm effectively assist in designing pMHC multimer constructs that will most likely capture T cells.
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PMC11708541
Key strategies, mainly transition metal-catalysed reactions, green chemistry approaches, and novel synthetic routes, have significantly contributed to the progress in this field.
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PMC11248911
Based on the aforementioned information and continuing our research on natural bioactive compounds, the authors developed a new series of pyrazoline based APN inhibitors, starting from the naturally occurring benzylidene acetone compound, to examine their inhibition effect on angiogenesis, invasion and migration by inh...
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PMC11711663
We collected six clinical attributes in the training set, including race, gender, tobacco use, alcohol consumption, stage, and treatment modality, summarized in Table 1.
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PMC11424574
Treatment with Rh-uPA protein restored the osteosarcoma cell migration (shMTA2-HOS cells, 167.3% increase; shMTA2-143B cells, 114.5% increase) and invasion (shMTA2-HOS cells, 141.2% increase; shMTA2-143B cells, 122.5% increase) by MTA2 depletion, compared with shMTA2-OS cells (Figure 4).
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PMC10093184
Induced by the 3D growth, cells formed mineralized nodules detectable with von Kossa staining in all but COS4288 spheroids (Figure 8).
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PMC11644761
These compounds have attracted considerable scientific interest due to their potential health-promoting properties, particularly in aging, longevity, and the prevention of age-related diseases .
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PMC11751675
The tested compounds demonstrated strong binding to the M active site, specifically to the Cys145 residue, with binding energies ranging from −5.2 to −8.1 kcal mol.
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PMC9429973
The post-remission phase ended at the earliest relapse or end of follow-up (ie, death, end of eligibility or of available data [Dec 31, 2016]).
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PMC11610461
A, B) The cell proliferation assay showed the influence of different concentrations of metformin on the proliferation ability of A498 cells (in each group, n = 3). (
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PMC9429973
Aims: This first-in-human, Phase I study had the objective to assess feasibility, safety and toxicity of ex vivo generated MB-CART2019.1 in mainly elderly patients (pts) with relapsed or refractory (r/r) CD20 and CD19 positive aggressive B-cell Non-Hodgkin lymphoma (B-NHL) without curative treatment option (NCT03870945...
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PMC9046263
IDH-wild-type GBM patients with increased ERVK3-1 expression (> 3.3 FPKM) have a worse OS (17.9 vs. 12.9 months, p = 0.028).
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PMC10482220
N. Kedersha and P. Anderson (Brigham and Women’s Hospital, Boston, MA, USA).
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PMC5673060
4Phosphoproteomic profile of DasR versus A204 parental cells. (
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PMC11742431
Furin treatment for 0 h as a control.
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PMC11401350
We generated thus a unique new murine Tfh lymphoma model that can compensate for the low prevalence of the striking resembling human AITL and gives the opportunity to evaluate novel therapeutic approaches such as pathway interference or immunotherapies .
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PMC11747949
All these proangiogenic and pro‐inflammatory cytokines are angiogenic and implicated in cancer metastasis (Gálvez et al. 2005; Pausch et al. 2020).
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