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OTAR3088
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PMC11015054
We incubated the cells for 24 h then removed from chambers, fixed with 4% paraformaldehyde, the upper chamber was stained with crystal violet 0.1% and gently wiped with cotton swabs.
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PMC11224020
Consistently, confined DCs were less efficient in activating T cells than LPS-treated cells.
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PMC7039683
Plotting the average score of tiles overlapping the training set and that of those that do not was useful in conveying the potential of this tool to distinguish periderm enhancers based on sequence alone.
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PMC11535726
Although they are morphologically similar, there are also sufficient dissimilarities in the DNA sequence data.
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PMC9429973
These experiments validated an essential function for the two well-known depleted candidates CXCR4 and ITGB1 in both PDX models in vivo.
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PMC11665584
Multiple comparative studies of oral and cutaneous wound healing have leveraged transcriptomic methodologies to identify the differences in healing progression (5).
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PMC11476222
Despite the power of these methods, challenges remain, particularly in the separation of ganglioside isomers.
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PMC9429973
Of 6 patients tested for hemochromatosis genes, 2 were negative for the common mutations of HFE, TfR2 FPN1 genes, 1 was found double heterozygote for the His63Asp and Cys282Tyr HFE mutations and 1 patient carried the HFE H63D mutation.
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PMC11746942
For Masson’s trichrome staining, skin tissue samples were first fixed in Bouin’s solution, then deparaffinized in xylene and rehydrated through a graded series of alcohols to water.
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PMC9429973
References Hansen, M. H., Cédile, O., Blum, M. K., Hansen, S. V., Ebbesen, L. H., Bentzen, H. H. N., . . .
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PMC10919056
This study combines the survival information of ccRCC patients in the TCGA database (including survival status and survival time) with the gene expression data of GJP to generate a total sample (total sample, TS) for data analysis.
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PMC7917457
Furthermore, the expression of murine OX40L and CD40L from VALO-mD901 significantly increased the number of OVA antigen-specific T cells in tumors, as well as increased the number of OVA antigen-specific T cells in tumor-draining lymph nodes.
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PMC9221284
Translation of the two transcripts in the three reading frames predicts (Figure 3) the formation of c-Myc1 (Trans1) and c-MycS (Trans2) isoforms.
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PMC9429973
No statistical differences were observed regarding survival after HSCT (9.6 vs 10.3, p=0.773).
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PMC9684669
D, E) Synergy matrixes (bottom) and surface plots (top) show the synergy between doxorubicin and terfenadine on A2780 (D) and A2780-ADR (E) cells (n = 3). (
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PMC9096373
The protein expression level of Ki-67 in the DDPs + RT group was lower than that in the control and RT groups (reduced by 54.1% and 35.6%, F=38.33 and 10.68, respectively; P<0.05).
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PMC11224020
For animal care, we strictly followed the European and French National Regulation for the Protection of Vertebrate Animals used for Experimental and other Scientific Purposes (Directive 2010/63; French Decree 2013-118, Authorization DAP number 43530-2023051216135493 v2 given by National Authority).
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PMC10899471
Data were presented as mean ± SD and analyzed by using Graphpad Prism 8 software.
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PMC9622879
In the community with the prosumer-centric CEMS and proposed CEMS, from time slot 15 to time slot 24, the homes do not require energy from the EP because they can share energy when they have surplus energy from their PV systems or ESSs.
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PMC6892818
Although both JNK/p38 were essential in apoptosis, p38 activation was JNK-dependent, which is the first report of such temporally defined JNK-p38 interplay during an apoptotic programme.
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PMC9429973
The mean age at death was 83 (SD 4.8) years in the oldest age group, but in none of the age groups, the leading cause of death was MM.
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PMC11787381
The study revealed a fourfold higher ratio of brain to plasma concentrations of the formulated bambuterol when administered through the IN route than when administered through the IV route as a bambuterol solution.
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PMC9429973
During cycles 3 and 4, R-CHP will be added to BV-Nivolumab.
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PMC11055510
Overexpression/knockdown of circMAN1A2 in OC cells was used to decipher its effects on cell proliferation with a Cell Counting Kit-8, 5-ethynyl-2’-deoxyuridine (EdU), cell cycle, clone formation, and wound healing assay.
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PMC11745823
This study demonstrates that RIT1 significantly contributes to the aggressive phenotype and unfavourable prognosis of glioma, indicating its ability as a therapeutic target for glioma treatment.
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PMC11536589
All experiments were conducted independently at least thrice.
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PMC11750712
Leukapheresis stage followed by AUTO4 manufacture; Preconditioning stage consisting of lymphodepleting treatment with Flu (30 mg m on days −6 to −3) and Cy (500 mg m on days −6 and −5) (Flu/Cy) before AUTO4 infusion; Treatment stage in which AUTO4 is administered intravenously as a single infusion on day 0; Follow-up s...
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PMC2196094
In addition, nearly full-length cDNA probes for the rat α chain of the high-affinity receptor for IgE (IgERI-α), the mouse γ chain of the IgERI, the rat Mac-2 cell surface marker (the IgE binding protein), mouse lysozyme, a partial cDNA clone for the 3′ region of the rat c-kit receptor, a cDNA covering the entire codin...
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PMC6163708
Proliferation assays and TUNEL assay were quantified by ImageJ software (National Institutes of Health, Bethesda, MD, USA).
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PMC11366496
The data were reported as the Mean ± SD, derived from three autonomous experiments. *
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PMC6600592
Compound 4B-2 among these compounds showed the best inhibition of HBsAg and HBeAg secretion.
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PMC11726183
Triplicates were used for performing all experiments and the cytotoxicity was expressed as a percentage of cell viability compared to untreated control cells.1 In this work we have utilized different Softwares for computational calculations to analyze protein–ligand binding, binding stability of protein–ligand complex,...
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PMC11575040
Cells were added to the upper chamber of a Transwell membrane.
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PMC9429973
Hematological parameters and splenomegaly were monitored over time while BM and spleen fibrosis were evaluated at sacrifice.
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PMC11434983
Cytotoxicity half-maximal inhibitory concentration (IC50) was calculated, and, in this paragraph, the term IC50 refers to the cytotoxicity results.
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PMC11715644
These migratory and shape transitions into confined regions reduce with EMT-like +ErbB2 mutant cells.
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PMC11300085
The cell scratches were captured at 0 and 24 h after chemerin treatment.
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PMC8873393
Histogram plots of average EU incorporation after UV irradiation are shown on the right panel.
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PMC9621239
The siRNA (10 pmol) of MYC or the control was transfected into Huh 7 cells and Bel-7404 cells in a 6-well dish respectively. (
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PMC9429973
Adequate material at and/or following HSCT was available for 22 RUNX1mut pts (up to 28 days prior to HSCT [n=19], during post-HSCT follow up [61 samples in 11 pts] and at relapse [n=3]).
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PMC11638288
In patients with acute and chronic HCV infections, the expression levels of NKp46 in the liver are significantly elevated.
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PMC11711063
After 24 h, inserts were removed and cells treated.
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PMC11495567
Statistical significance (*p < 0.05, **p < 0.01, and ***p< 0.001) was determined by One-Way ANOVA with post hoc Dunnett’s test.
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PMC6889484
Lower blot probed with α-A3G antibody (green bands) and α-tubulin antibody (red bands).
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PMC11665555
For nuclear fractionation, the cytoplasmic fraction was extracted with hypotonic buffer (20 mM Tris-HCl [Thermo Fisher Scientific], 10 mM KCl [Thermo Fisher Scientific], 2 mM MgCl2 [Sigma-Aldrich], 1 mM EGTA [Sigma-Aldrich], 0.1 % IGEPAL [Alpha Aesar] [pH 7.4]), and the nuclear fraction was extracted with isotonic buff...
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PMC11589157
The average length of the coding genes was 28,215 bp, with an average of 7.71 exons per gene.
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PMC10502403
The Roman numerals (I, II, and III) at the top of each sample name indicate that the T cells were derived from the same healthy donor and induced on the same day.(A) Heatmap of 357 metabolites (cationic:195, anionic:162) detected by CE-FTMS compared among unstimulated NGMCs (blue; Ⅰ-1, Ⅱ-1, and Ⅲ-1), unstimulated NE1-G...
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PMC11637284
The region targeted by the TAC60 RNAi is shaded in grey and mapped to the full length protein.
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PMC11528603
this study aimed to elucidate the anti-leukemic effect of romdoul fruit extracts and their underlining mechanisms.
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PMC7192625
A screen shot of the GARDEN-NET web-tool showing the main components: 1) the viewer on the left shows the network for the selected species and cell type; 2) the tool-tip shows properties of the node; 3) the search box allows to search for genes or genomic regions; 4) the viewer on the right shows the searched region or...
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PMC9429973
Summary/Conclusion: In vivo targeting of HSP90α is a promising approach to target BCR-ABL1+ leukemia cells.
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PMC11200978
Gage et al. and others have shown similar translation of in vitro MLT studies on prostate cancer to clinical application wherein the MLT of −40 °C has been established .
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PMC7369657
Mitochondria are involved and play a central role in the integration and circulation of death signals initiating inside the cells (such as oxidative stress, DNA damage) in regulating cell death pathways.
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PMC11200978
While referred to as the MLT, in practice it is important to recognize that this represents a minimal target.
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PMC11711871
One day before transfection, the cells were grown in medium containing charcoal-stripped serum.
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PMC11621493
Total DAG levels calculated as sum of sn-1,2 and sn-1,3-DAG band intensities shown in (H). (
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PMC11597291
Cells were then re-suspended to 100 μL 1xAnnexin V binding buffer with 5 μL FITC Annexin V solution (in the dark, 15 min).
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PMC11487720
This is due to the increased permeability of nuclear membrane and the enlarged nuclear pores .
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PMC11734514
PI3K/Akt Signaling mRNA Expression (PTEN, Akt, mTOR, and STAT-3) in A549 cells treated with C. aerizusa. (
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PMC11604768
The composition of our library enables users to select not only high fold-change reporters, but synthetic promoters from a wide range of sensitivities and amplitudes tuned for a given engineering application.
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PMC11748335
Notably, there was no significant difference between peaks in H3K9me3 short LOCKs and typical H3K9me3 peaks in the enrichment of common PMDs and common HMDs (Fig. S1E).
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PMC3888431
Simultaneously, a reference cultivation under standard conditions was conducted for both experiments.
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PMC6684588
It is therefore significant that Smad2/3-pathway activation by ligands such as myostatin not only regulates myoblast function but also induces fibroblast proliferation, reduces fibroblast apoptosis, and promotes fibrosis – which is reversible by ActRIIB-Fc – in skeletal muscle of mice.
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PMC11476222
In this study, we optimized extraction conditions, LC-MS analysis, and data processing to enable easier, faster, and more reliable analysis of gangliosides and other sphingolipids.
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PMC11519788
Given the negative correlation between SPOP expression and macrophage infiltration in human specimens and mouse xenografts, we investigated the role of SPOP in modulating macrophage recruitment in UBC.
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PMC11295144
Myc-tagged GABAARs were immunoprecipitated using a myc-specific antibody, followed by detection of NL2 by immunoblotting using an anti-NL2-specific antibody. (
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PMC8382973
2P23 is a novel short peptide (23 mer) fusion inhibitor with an M-T hook structure, HIV-2 sequence and salt bridge formation residue, and a molecular weight of 3717.96 g/mol (2P23 amino acid sequence: EMTWEEWEKKVEELEKKIEELLK).
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PMC11467800
Phenotypically, K562‐IR cells are highly adherent and exhibit characteristics of partially reprogrammed cells.
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PMC9429973
Demographics and disease features are collected at baseline.
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PMC10033453
Serum collected from two patients treated with VSV-human IFNβ (hIFNβ) in a phase I clinical trial (ClinicalTrials.gov: NCT01628640) at day 22 post-treatment was also tested for neutralization potential and was shown to inhibit oncolysis at dilutions up to 1:2,560.
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PMC3765139
However, the distribution of the expression was highly variable among the cell lines under investigation (Table 3).
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PMC11478724
These findings suggest that hsa-MiR-320a could be a promising gene therapy strategy for people with lung cancer.
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PMC11576293
Therefore, we decided to test compounds 9–29 against a panel of four cancer cell lines.
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PMC11180402
These results indicate that the SOX2 binding site in the SNHG1 promoter is crucial for ISO-mediated inhibition of SNHG1 promoter transcriptional activity, further demonstrating that SOX2 downregulation is responsible for SNHG1 inhibition by ISO.
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PMC11684821
This study also asserted that Jurkat cells expressing the MC.7.G5 TCR only responded to MR1*01 expressed on targets at supraphysiologic expression levels (29).
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PMC9429973
Br J Haematol, 2018), understanding seasonal variation of CAD manifestations may be important to guide nonpharmacological management strategies and prophylactic recommendations (Lyckholm et al. N Engl J Med, 1996; Berentsen et al. Hematology, 2007).
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PMC11461833
Importantly, STXBP5 directly interacted with progerin but not lamin A. Therefore, our findings identify STXBP5 as a new regulator of progerin and suggest that it may be a therapeutic target for HGPS.
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PMC11387401
Additionally, recent reports have shown that nascent RNA often interacts with regulatory proteins to regulate gene transcription, to the extent that all pre-mRNAs may be considered as ‘bifunctional RNAs’, possessing both coding an regulatory functions (Skalska et al, 2017).
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PMC11791264
4,6-diamidino-2-phenylindole (DAPI, C1005) was purchased from Beyotime Biotechnology.
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PMC11803149
A, B) n = 4 per group, biological replicates.
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PMC6892818
Results are presented as Cell death fold increase in background-corrected RLU readings relative to control (mCD40L treatment vs. controls) and are representative of three independent experiments.
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PMC6835428
From a functional point of view, the authors observed that the injection of an anti-luciferase siRNA delivered via the FR-targeted particles resulted in a significant reduction of luciferase expression 24 and 48 h post IP administration (35 μg siRNA-luc) compared to a control siRNA.
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PMC11380454
Moreover, while αPD-1 was significantly effective in both experiments compared with isotype control antibodies, compared with each treatment alone, cotreatment with αPD-1 and AS101 or with 1 or 1.5 mg/kg SAS further decreased tumor volume.
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PMC9429973
Evaluation of the combination of agents in mouse models suggested that increased necroptosis signal and immune-potentiating biomarker modulation can be achieved in vivo.
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PMC11623887
GFP groups transfected by pmaxGFP were used to assess the transfection efficiency.
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PMC10976516
Myxoma belongs to the pox virus family and only infects rabbits but no humans or other non-leporid animals, while at the same time selectively infects and lyses cancer cells from humans and various other species.
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PMC11252553
, irradiated at 12 Gy, and incubated for 48 hours, Group X. treated with cysteine (100 µg.
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PMC8777939
Therefore, a novel and effective anticancer drug is needed.
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PMC11499381
Twenty fields of view were captured per well.
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PMC11711063
Scratch assays of ER‐positive and triple‐negative breast cancer cell lines demonstrated that ZG16B stimulated cell motility independently of their hormone receptor status (Figure 4A).
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PMC10253553
We show that RICTOR and mTOR in complex 2 promote the levels of NDRG1 protein and phosphorylation of NDRG1 (Thr346) (Figure 2 and Figure 3).
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PMC11787355
No difference in population frequencies was observed when comparing therapeutic PTPRZ1-TCR-T- with control TCR-T-treated mice (Fig. 4i), suggesting that the engraftment and CD8 T cell subset maintenance were independent of cognate antigen encounter in vivo.
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PMC11047729
Unfortunately, its application in therapy is limited due to its calcemic properties.
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PMC11736898
A recently published study utilizing a mouse excisional wound model found that wound closure was delayed in vitamin D-deficient mice, but was enhanced by vitamin D supplementation .
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PMC3765139
Established melanoma cell lines exhibit, to variable extents, the typical features of CSCs.
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PMC11686380
The p.E146K variant site was highly conserved among species (Fig. 1D), and predicted to be pathogenic by four web-based in silico analyses.
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PMC8956657
Source data are provided as a Source Data file.
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PMC9429973
Fifty eight of 79 patients (73.4%) were hypertensive; however, an association was still found between thrombotic event and DTA mutation in this group of hypertensive patients (p=0.033).
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PMC11683240
This suggests that interaction of PT and α1AT during the preincubation might be relevant for better inhibition of PT.
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PMC9412887
The study findings are very encouraging and strongly indicate that nanomedicines have great potential to overcome drug resistance in cancer.
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