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PMC9817179
Fixation is complete in ~100 s. The green scattered plot represents actual data points, and the blue line plot is to guide the eye.
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PMC11777207
Migratory XCR1 cDC1s travel the furthest into the dLN because of high levels of membrane-associated CCR7, which guide them deep into the paracortex, where CD8 T cells reside (19, 22, 24).
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PMC10734950
Thiophenes and thiophene derivatives have emerged as an important class of heterocyclic compounds that have displayed favorable drug characteristics.
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PMC10174970
If a gene was detected with multiple probes in an array, the expression level was taken as the average value of all probes.
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PMC9812014
HSV is classified into two serovars: HSV-I and II.
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PMC11770130
The results were processed with UniProt human protein database (75,004 entries) and using Protein Discoverer (Version 2.4, ThermoFisher Scientific) with Mascot (Version 2.7.0, Matrix Science).
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PMC9429973
Study objectives included safety and efficacy profile.
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PMC6268318
The crude extract inhibited secretions induced in rats by pyloric ligation together with histamine (Table 1).
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PMC11547917
Further interdisciplinary collaboration between research scientists and physicians could lead to improved phytotherapeutically formulas by refining extraction protocols and removing the phytotoxins, and guarantee secure and effective integration of these medicinal plants into contemporary therapeutics.
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PMC11765243
In contrast, our previous data in a model of T cell-specific deletion of p110α (p110α ΔT model) showed no significant differences in thymus cell numbers or subpopulations ().
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PMC9436459
At the early stage of the synthetic route, the Diels–Alder reaction was utilized to assemble the cyclohexene moiety of the tricyclic core.
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PMC11694625
At the same time, hydrazine reacts with substances containing methyl groups (dichloromethane/anhydrous methanol) to form NDMA's amine precursor dimethylamine.
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PMC11525028
Data was analyzed using MicroCal PEAQ-ITC Analysis Software and KD was calculated.
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PMC11794568
A further analysis of CRIP1 expression in relation to clinical features showed a notable association between low CRIP1 levels and advanced T-stages, particularly T4 (Fig. 1C), as well as melanoma ulceration (Fig. 1E) and Clark levels (Fig. 1F).
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PMC9429973
To clarify the risk factors for sPGF, 17 sPGF cases and 382 without PGF were further analyzed.
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PMC11347429
Duke University (Durham, NC USA): Patients were enrolled by convenience sampling in the emergency department based on the presence of a suspected infection of less than 28 days duration.
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PMC11502962
Imatinib, sunitinib, regorafenib, and ripretinib have been approved for the treatment of GIST.
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PMC11577421
Therefore, given that each NP is coated with approximately 200 albumin molecules, we can estimate a PCX concentration of around 1 μM for a 1 nM NP solution.
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PMC9429973
Further analyses assessing the impact of the CS-sparing effect observed with RUX are warranted.
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PMC10470467
In the current study, we first developed a novel prognostic NRG signature to predict the prognosis of ES patients.
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PMC11087766
The average titer of wild-type PhiKZ was normalized to one and the efficiency of plating for each mutant was determined relative to the wild type.
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PMC9429973
OS at 3 years did not differ among patients with high vs. low HCT-CI scores (median 1.02 years vs. NA, p = 0.38).
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PMC11279397
Its dried stems, leaves, and seeds have been utilized as medicinal materials.
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PMC8041314
To 20 μL of the test compounds in different concentrations in a clear flat-bottom 96-well plate (Thermo Scientific, Waltham, MA, USA), 160 μL of the cell suspension containing approximately 45,000 H69 AR cells in colorless culture medium without supplements was added.
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PMC2944824
Evidence was presented indicating that Hr affects these earlier events.
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PMC11770746
We tested the in vitro potency of cisPt(Pac)(OH) in comparison with cisplatin, paclitaxel, and their 1:1 physical combination against a panel of cancer cell lines, which included human ovarian cancer cells sensitive (A2780) and resistant to cisplatin (A2780cisR), melanoma cells (A375), non-small-cell lung cancer cells ...
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PMC10656496
Bar graphs showing the growth of 143B in different media types at day 24.
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PMC9429973
A. Samoylova, V. Sarzhevskiy, V. Melnichenko, N. Mochkin, A. Rukavitsyn, E. Smirnova, V. Bogatyrev, A. Bannikova Department of Hematology and Chemotherapy with a room of bone marrow and hematopoietic stem cells transplantation, NMSC named after N.I. Pirogov, Moscow, Russia Background: High-dose chemotherapy (HDCT) foll...
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PMC7053076
Data are expressed as mean ± SEM.
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PMC10706275
Furthermore, strategies rooted in cell biology can enhance the production of target proteins, potentially by targeting key molecules involved in cell cycle regulation, apoptosis, or metabolism .
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PMC8567602
E, WBs for SS18 and SMARCB1 in glycerol gradient fractions (only 20 total for glycerol 10% to 30%) for HA-purified complexes.
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PMC10944868
Structure-Activity Relationship (SAR) of synthesized cyanovinyl ethers.
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PMC11291697
Glycine and serine are biosynthetically linked amino acids in that serine is converted into glycine by the serine hydroxymethyltransferase enzyme (SHMT).
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PMC11489351
The clear supernatant was then carefully transferred to a new tube and stored at −80 °C until further analysis.
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PMC11802855
The transfection complex was prepared by mixing 125 μL of RPMI 1640 medium (Gibco, USA), 3.75 μL of Lipo3000 reagent (Thermo Fisher Scientific, USA), and 10 μL of siRNA.
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PMC3888431
The number of unique gene loci were counted for each cluster and vice versa.
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PMC11224020
Whether cPLA2 activation has any impact on the transcriptional activity of immune cells is unknown.
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PMC9429973
Aims: The primary endpoints were a qualitative and quantitative functions of plasma von Willebrand factor (vWF) which include measurements of vWF activity (vWF:ristocetin cofactor [vWF:RCo]), vWF level (vWF:antigen [vWF:Ag]), factor VIII coagulation activity regarding to vWF(vWF:FVIII) and FVIII activity (FVIII) as an ...
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PMC9429973
The ORR was 85% (212/249): where 91% of patients (195) achieved CMR and 9% were with PMR.
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PMC11783017
J, K) Cell apoptosis analysis of 143B cells after treatment for 24 h by flow cytometry using Annexin V-FITC/PI kit. (
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PMC11740907
Before being put onto comet slides, the cultivated cells were treated with 1% LMPA.
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PMC11786704
4 Therapeutic effects of PC capsules on wound healing. (
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PMC4112127
From the ROC, point estimates for sensitivity (with 95% confidence intervals, CI) were calculated by the efficient score method after setting specificity to 100%.
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PMC9532503
Currently, there are several new generations anti-CD20 mAbs engineered and/or modified to improve antitumor activity and Fc-binding affinity.
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PMC11423992
Furthermore, its killing curve EC50 value was an order of magnitude greater than that of TFAB002s, highlighting a favorable balance between safety and efficacy.
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PMC11683240
Similar to cluster two, mutations in cluster three led to a drop in stability.
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PMC9960565
The chloride ions will then substitute the dendrimer carboxylate groups in the coordination sphere of platinum (exchange reaction), and the subsequent in situ aquation of cisplatin will give rise to potent electrophilic cations that bind to DNA and cause cytotoxic effects.
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PMC11574271
D Upon the end of the study, all animals were dissected to confirm any organ metastases.
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PMC9019892
Approximately 80%–90% of GIST patients initially achieve disease stabilization after imatinib treatment, which is typically indicated for unresectable or disseminated disease .
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PMC8193046
Vigneshwaran Namasivayam: Conceptualization, Methodology, Software, Validation, Formal analysis, Investigation, Data curation, Writing - original draft, Writing - review & editing, Visualization, Supervision.
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PMC9872547
Carcinogenic HPV types (such as HPV16 and HPV18) target cervical epithelial cells and are responsible for almost all cases of cervical cancer (13).
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PMC11348300
The rapid transients of the HS values imply that PpIX resides within cellular compartments, proximal to sites of oxygen consumption.
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PMC11612626
The lysate was mixed with the H-2 MHC-I M1/42 antibody (2 mg in 100 μL) for the murine immunopeptidome and the MHC-I W6/32 antibody (2 mg in 100 μL) for the myeloma immunopeptidome.
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PMC9429973
Using our pseudotime approach, we discover a variety of different gene responses of the HSPCs to the treatment.
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PMC9429973
The patients’ responsiveness to the administration of ibrutinib, the duration of the response, the prognostic factors affecting the response, and the side effects associated with ibrutinib were analyzed retrospectively.
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PMC11794847
We conducted RNA sequencing for both HVEM knockdown and control groups in jurkat cells to delve deeper into the intrinsic biological roles of HVEM (Supplementary file 3).
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PMC11021472
Relative cell growth was assessed by following the percentage of RFP cells over three weeks post-transfection from three independent experiments, with the RFP percentage normalized to day 4 after transfection.
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PMC11753435
For the given test set, RFDiffusion was tasked with generating one peptide binder per target protein, matching the length specified by the ground truth binders.
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PMC11721587
Upon Hh stimulation, key pathway components including Smo, Gli, and Sufu translocate to primary cilia (33–38), leading to the hypothesis that Gli proteins are converted into Gli at primary cilia.
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PMC11188874
HR23B is a biomarker previously identified in a genome-wide loss-of-function screen which influenced sensitivity to HDAC inhibitors (32).
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PMC7229095
In the case of CDM2, we adapted commercial cloning media reported to support good growth for the single clones (Sealover et al. 2013).
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PMC9429973
Methods: We used the MDS-L cell line as a model to limit the heterogeneity observed in MDS patients.
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PMC4695073
We investigated whether clinical stages, which combined T and N classifications together, affect the overall survival in this population of NPC patients, but the result was strange because no difference for OS between the patients at stage III and the ones at stage IVa/b (Supplemental Figure S4A).
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PMC7215722
Lipid rafts (LR) are known to play an important role in the trafficking of SI and DPPIV.
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PMC9024365
COS cells were grown in COS media containing DMEM (Life Technologies) supplemented with 10% Fetal Bovine Serum (Fisher Scientific) and 1% Penicillin/Streptomycin (Life Technologies).
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PMC11754432
Next, inhibition of EGFR via PD168393 was performed in combination with ALOX15B silencing.
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PMC11411131
Nonetheless, concerns persist regarding the potential synergistic effects of these toxicants in in vivo situations.
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PMC11394730
One of the most studied naturally occurring flavones among chemicals obtained from plants is luteolin (3′,4′,5,7-tetrahydroxyflavone), a subclass of flavonoids made up of a C6–C3–C6 carbon skeleton with two benzene rings connected by a heterocyclic ring Its chemical appearance is that of a yellow crystalline material w...
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PMC10898159
The c-KIT-Hsp90Β-Apaf-1 complex inhibits the ubiquitination degradation of mutant KIT.
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PMC9429973
We showed that the combination of HSP110 inhibitors with copanlisib also decreases SYK/BTK and AKT phosphorylation synergistically, leading to less NFkB activation in vitro and in vivo.
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PMC6835762
It should be noted, however, that this data was not published, and there are no published examples of PGA applications tested in vivo.
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PMC3931643
In all, 100–200 µg of protein from the lysates was then incubated with a suspension of 7 methyl-GTP-Sepharose 4B beads (GE Healthcare Life sciences), and placed on a rocker at room temperature.
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PMC10362265
Further, given that this epitope holds the C74, we note that the proposed disulfide contact in the human tetramer might be an allosteric disulfide bond .
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PMC11637284
Here we have characterized the interaction between p166 and TAC60 on the molecular level.
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PMC9920575
As shown in Figure 5, S. chinantlense extract did not significantly increase caspase-8 activity in HeLa or HaCaT cells, after cisplatin treatment for 24 h, caspase-8 activity increased in HeLa cells but not in HaCaT cells.
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PMC9429973
However, we found a high rate of infectious complications and IRM (26%) with a higher infection related deaths in patients in CR/PR who were treated with HMAs+V (P=0,005).
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PMC9429973
Within a median follow-up period of 112 months since MM diagnosis and 31 months since SPM detection, 50.5% (n-101) have died; 32 due to solid cancer (32/101, 28%), 11 due to hematological cancer (11/46, 24%) and 13 (6%) due to MM progression.
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PMC11023271
Data were pooled from two independent experiments.
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PMC11519583
The graphs on the right show the relative band intensity of Wnt5b and Wnt11 in anti-HA immunoprecipitates, which were normalized by the corresponding levels of Wnt5b and Wnt11 in WCL (n = 5).
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PMC7802142
n ≥ 3; *P < 0.05, **P < 0.01 versus the PBS groups by One-way ANOVA ReN-NV treatment promotes β-catenin signaling pathway in DPCs.
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PMC9429973
Hospital Maciel, Montevideo, Uruguay Background: COVID-19 has a pleomorphic presentation that goes from asymptomatic patients to critical disease with pneumonitis as the lead complication.
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PMC11767793
The UV–Vis measurements of the Au-PEI@NIST suspensions subjected to multiple centrifugal filtration cycles showed identical gold SPR bands regardless of the centrifugation cycle number (Figure 4a).
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PMC10114490
Number of cells counted was 360, 470 and 300 for 6d-0.5%; 6d-10% and 2d-10%, respectively. *
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PMC3675084
Identifying novel agents that overcome paclitaxel resistance is urgently needed.
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PMC10975211
Non-communicable illnesses, especially cancer, continue to pose a significant global public health challenge.
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PMC11666785
The corresponding raw data along with super-resolved images (comparing SMLM and corrSMLM) is shown in Supplementary Videos 3 and 4.
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PMC11779960
Since Thiele et al., did not provide such analysis, we believe their findings do not add significantly to what has already been described by Iyer et al.. In summary, technical limitations and small numbers of samples limit the usefulness of the findings of Thiele et al. However, the elegant work of Iyer does indicate t...
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PMC9429973
16% had high risk simplified MIPI, 57% had Ki-67 ≥50%, 41% had blastoid or pleomorphic variant, 49% had TP53 alteration, 31% had complex karyotype, 14% had bulky disease (≥10 cm), and 10% had CNS involvement.
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PMC11770130
The energy content of diet and feces was measured by a bomb calorimeter (IKA) according to the manufacturer’s guidelines.
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PMC11265931
The p53 (Figure 3A), Cas3 (Figure 3B), Bax (Figure 3C), Cas9 (Figure 3D), and Bcl-2 (Figure 3E) expression levels in U-87, SH-SY5Y, PC-3, Panc-1a, Hep3B, and HUVEC cell lines were analyzed.
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PMC11026382
Plot layout and color coding is identical to (c).
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PMC9429973
Flow cytometry- Quantification of the T cell activation markers, CD134+ CD25+CD4+ T-cells was performed (Act-T4 Cell kit, Cytognos, Spain), and any response above 0 was considered positive.
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PMC9429973
Respect a possible interaction of targeted therapy drugs (midostaurin or venetoclax) with antifungal agents, 40% would use broad-spectrum azoles and 38% echinocandins as prophylaxis.
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PMC9822769
According to experimental evidence and QSAR studies, cellular accumulation of most Pt(IV) compounds is strictly dependent on their lipophilicity, and this is a significant clue to passive diffusion [6, 40–45].
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PMC11670407
However, in the tumor specimens collected at our hospital, immunohistochemistry revealed that GPX4 expression was higher in postchemotherapy patients (n = 6) than in prechemotherapy patients (n = 6) with OS (Fig. 4l).
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PMC11786156
We also referred to archived IHC slides when available.
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PMC11769522
For the effect of different cytokine stimulators on cytokine production, each dataset was compared to that of the control group treated with vehicle, using the Mann–Whitney U test or an unpaired Student’s t-test, depending on the normality.
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PMC11656657
Tumors positive for GD2 include pediatric embryonal tumors and several adult cancers.
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PMC10237474
Together, these results showed that protein complexes with high quality for structural biology can be expressed and purified from both GnTI cell lines.
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PMC11721587
In vitro experiments revealed that Ulk3/CK1 phosphorylates IPS1/2 to promote their SUMOylation (fig. S6, A to E).
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