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OTAR3088
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BioData-CellLine_annotated

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PMC2614416
They include: reverse transcriptase polymerase chain reaction amplification , immunohistochemical staining , in-situ hybridization , and Western blotting .
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PMC9429973
In large-scale genomic studies, the mutational landscape of somatic single nucleotide variants and indels as well as copy number gains and losses based on array CGH have been well described in both subtypes.
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PMC11092382
Additionally, Zhang et al. conducted a study on the therapeutic potential of sophocarpine in mitigating doxorubicin-induced heart injury in mice and H9C2 cells.
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PMC11549062
Eight‐week‐old female mice of wild‐type and ApoE mice on a C57BL/6 background were obtained from SPF Biotechnology (Beijing, China).
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PMC11345828
The crude residue was purified by flash column chromatography eluting with either EtOAc/hexanes to afford the desired compound.
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PMC8922418
Enhanced Cas9 (eCas9), which is an engineered Cas9 variant first developed by two groups independently, termed enhanced Cas9-1.1 (eCas9-1.1) (Slaymaker et al., 2016) and Cas9 high-fidelity variant 1 (Cas9-HF1) (Kleinstiver et al., 2016), which has minimal or no detectable off-target effects in human cells but lose some...
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PMC11766309
Furthermore, characteristics and profiling of tumor-infiltrating immune cells were performed via the ImmuCellAI (http://bioinfo.life.hust.edu.cn/ImmuCellAI#!/) portal.
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PMC11763111
Despite certain drawbacks such as a limited experimental window (4–8 weeks), graft-versus-host disease (GvHD) risks, and a low survival rate of NK cells , this model proved to be the most suitable for our investigation.
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PMC11366496
By not only treating LN‐229 and A‐172 cells with JAK/STAT inhibitor WP1066 (6 μM, 48 h) to further determine the RNF122 ability to promote cell proliferation through JAK/STAT activation but also by investigating RNF122 overexpression effect on proliferation, it was revealed that consistent with the earlier conclusion, ...
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PMC11541241
The upstream regulation signals sensed and downstream targets controlled by TOR complexes among diverse eukaryotic organisms have been thoroughly reviewed in numerous excellent studies (Brunkard, 2020; Burkart & Brandizzi, 2021; Eltschinger & Loewith, 2016; Jamsheer et al., 2022; Liu & Sabatini, 2020; Liu & Xiong, 2022...
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PMC10759659
R 3.
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PMC11248911
Complexes have been neutralized by adding 32 Na ions and have 113 Å, 113 Å and 113 Å dimensions for the PBC box in x, y and z, respectively.
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PMC11306019
Thus, specific positioning of the galloyl group on the carbon-6 of the glucose core significantly enhanced antagonistic activity.
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PMC10938336
The intricate network of molecular interactions, as exemplified by the Ras signaling pathway and microRNAs’ involvement in cancer, highlighted the complexity of these genes’ functions in cancer development and progression.
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PMC11155445
Adsorption kinetics study of the membrane showed that the adsorption of silver ions was faster at initial 1.5 hours and slightly decreased to the value of 1.45 mmol g at 5 hours.
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PMC11365427
The left chart shows the downregulated pathways, and the right chart shows the upregulated pathways. (
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PMC11541241
Taken together, the transgenic HIGS approach to target plant‐pathogenic fungal TOR has proved to be effective against several fungal types.
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PMC9429973
In these patients, WES or WGS should be used.
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PMC7961460
Diagnosis of ductal breast cancer (G2/G3) was confirmed histopathologically.
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PMC2614416
Ontologies are found in four databases: GR, UniProt, UNIPROT and RefSeq.
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PMC11476264
Next, we validated the protein interactions and mapped interacting domains by in vitro His pulldown assay.
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PMC11093197
RAS activity was quantified by immunoblotting of RAS after pulldown.
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PMC8658661
Ultrastructural analysis of cells in HB revealed well-formed intercellular junctions, numerous intermediate filaments, and rare cytoplasmic organelles: mitochondria and a rough endoplasmic reticulum .
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PMC11392912
The plasma was aspirated carefully and aliquoted in a centrifuge tube and stored in a −80°C deep freezer till further use .
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PMC11683240
After staining, the slides were examined via microscopy using the BZ-X810 Keyence fluorescence microscope (Keyence Deutschland GmbH, Neu-Isenburg) and BZ-X800Viewer v1.3.0.
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PMC11740207
In humans, these cells typically measure 10–15 µm in size.
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PMC9429973
R. Alonso Alonso, M. Rodríguez, L. M. Privette Vinnedge, J. Serrano, Y. Jiménez de las Pozas, S. G Pedrero, D. Laínez, A. García Raso, J. M. Alonso Dominguez, A. López García, R. Córdoba, M. A. Piris, P. Llamas Sillero, J. Sánchez García, J. Serrano Lopez Pathology, Fundación Jiménez Díaz, Centro de Investigación Biomé...
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PMC11788920
The gRNA components crRNAs and tracrRNA were annealed separately (each at 1.2 μM) at 95°C for 5 min followed by slow cooling to room temperature.
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PMC6461034
The filtered output only contains kinase predictions (“tree” = KIN) with a networkin_score of ≥ 2.0, which in addition exceeds 90% of the maximum score for a given substrate (substrates with string_identifier ENSP00000376688 are attributed to LYN instead of LCA5).
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PMC8740518
Finally, univariate Cox proportional hazards regression analysis was performed to determine relationships among amino acid transporter genes and prognosis.
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PMC9429973
Among these patients, 2% progressed to AML and 48% died during follow-up; median OS was 45 months.
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PMC11666785
In the case of high-density blinking, there is high chance for the overlapping of PSF both in the image and the subsequent images.
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PMC11055443
The V. cholerae exposure increased the mean NO production respectively to 8.28 ± 1.12 μM (P=0.01) and 16.63 ± 2.32 μM (P=0.0002).
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PMC9429973
The median OS and RFS were 8.6 and 12.9 months, respectively.
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PMC11593713
Data with skewed distribution were presented as median with lower quartile and upper quartile (Me(Q1; Q3)).
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PMC11684297
The dose-dependent decrease in cell viability for cancer cells was observed using the ZnO-NFs with a safe dose up to 200 µg/ml.
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PMC5874706
Experiments were conducted three times.
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PMC9429973
Our study shows an intriguing aspect that needs larger and collaborative researches.
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PMC11687663
Although the binding affinity of Quercetin (B12) was reported excellence but its stability issue, Schaftoside (B7) was consider best phytoconstituent to recommend for further investigation.
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PMC9684669
In addition, inhibiting the CAMK2/CREB1 pathway resensitized MDR ovarian cancer cells to not only doxorubicin but also paclitaxel and topotecan, which are clinically employed to treat ovarian cancer (48).
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PMC11365427
It has been reported that amino acid deprivation can disrupt cellular metabolic demand, destabilize endoplasmic reticulum homeostasis, and impair protein folding capabilities, thus inducing endoplasmic reticulum stress (ERS).
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PMC11472569
Cell-to-cell communication within the TME occurs through direct contact or the exchange of bioactive molecules via EVs.
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PMC11306019
The two VDMs of tetra-FV are positioned completely separately, with one in ring A and the other in ring B. This configuration affords the opportunity for both of its VDMs to interact independently with two distinct BTZ molecules.
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PMC11354225
In dermatology, to perform PDT, a cream containing a photosensitizer (PS) is applied to the lesion area and subsequently irradiated with visible light; the interaction of light, PS and cellular O2 generates toxic reactive oxygen species (ROS).
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PMC11528603
The ethyl acetate (SA-EA) and petroleum ether (SA-PE) fractions were filtered and concentrated using the rotary evaporator and freeze drier.
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PMC11438317
Other proteins proposed as LYP substrates include CD3ε, CD3ζ-chain, the ATPase VCP/p97, Bcr-Abl, C-Cbl and NLRP3 .
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PMC11578343
Notches in the boxplots (B, i and ii) represent the 95% confidence interval of the median.
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PMC8609870
3GO enrichment items and KEGG pathway analysis of DEGs.
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PMC10988555
The analysis of the UV–vis spectra and generation of natural transition orbitals cube files was performed with Multiwfn 3.8.
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PMC11621493
Statistically significant differences are shown as: ∗P < 0.05; ∗∗P < 0.01; and ∗∗∗P < 0.001.
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PMC9429973
Some patients with severe anemia may undergo splenectomy.
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PMC9812014
It has been reported that castanospermine treatment can reduce the expression of the mature glycoprotein (gp120) of HIV on the host cell surface, with concurrent aggregation of uncleaved precursor gp160, resulting in lower viral infectivity and also repressing the HIV-induced syncytium formation in the cultured cells .
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PMC11021472
Relatively little is known about the role of circRNAs in B-cell lymphoma.
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PMC11535726
Although Kirschsteiniothelia comprises numerous species, there are likely to be more undescribed species in this genus as predicted by Bhunjun et al. (2022).
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PMC11740508
B–F significance determined by one-way ANOVA with Tukey’s adjustment for multiple testing.
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PMC8382973
These findings suggest that the 2P23 gel is an excellent candidate for further development as a safe and effective pre-exposure prophylactic microbicide for the prevention of HIV transmission.
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PMC11792766
The plates were shaken rapidly for 10 min on an orbital plate shaker, and the optical density of the neutral red extract was measured at 540 nm using a SpectraMax iD3 plate reader.
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PMC8524093
The whole picture of antiviral mechanisms elicited by host cells against CHIKV is discussed in considerable depth by Nelemans and Kikkert (Nelemans and Kikkert, 2019).
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PMC7022782
if the excitation wavelength is changed, the scattering from the NPs will also shift and may interfere with the detection during surgery.
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PMC9512971
Furthermore, a collaboration between government, industry, and academia is essential for the development of therapeutic agents in a pandemic.
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PMC11674834
The amount of acetyl 3,4-DMA produced was determined following separation and quantitation by HPLC using following separation and quantitation by HPLC subjected to a gradient of 100% 20 mM sodium perchlorate pH 2.5/0% acetonitrile for 5 min to 0% 20 mM sodium perchlorate pH 2.5/100% acetonitrile over 10 min, then to 10...
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PMC11740399
The 3025@ML group was intraperitoneally injected with 25 µl 50 mg/kg 3025@ML once a day.
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PMC11484188
With a median survival time of 5-7 years after diagnosis, there is currently no cure for MM except allogeneic hematopoietic stem cell transplantation.
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PMC11695623
However, whether DCUN1D5 can regulate the glycolysis level of LUAD has not been reported.
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PMC11155445
The position and nature of substituents greatly affected the antifungal activities of compounds with compounds having electron-withdrawing substituents like fluoro at meta position having better activities compared to other electron donating groups.
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PMC11679033
Many mycotoxins are chemically stable enough to withstand processing or extraction, which means they can persist in contaminated hemp flowers and remain present in hemp products or even become more potent due to increased concentration .
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PMC11661040
K-L) Wound healing assay was performed to evaluate the migratory ability of stable CGREF1-knockdown cells compared to control cells.
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PMC8010066
Woods et al. (2019) observed that the expression levels of the lasI/R of P. aeruginosa in the co-culture with S. aureus increased.
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PMC9429973
Aims: In this study, we aim to investigate the mechanisms of the impairment of the niche cells by allo-immune reactions, and to explore a targetable pathway for myelosuppression after allo-SCT.
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PMC11750161
Phosphorylation sites in the C-terminal region of eel LH/CGR are essential for rec-eCG-induced phosphorylation.
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PMC11538390
Risk allele of the MCS-9.7 variant rs570516915 also showed genome-wide significant association in the Finnish replication cohort (P = 8.82 × 10) and suggestive evidence of association in the Estonian cohort (P = 1.25 × 10) with the direction of effect consistent across all three cohorts.
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PMC11683240
Values are given as mean ± SEM.
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PMC9792775
LFU combined with PTX significantly inhibited the growth of S180 tumors transplanted subcutaneously in Institute of Cancer Research (ICR) mice, and its enhanced effect may be associated with increased local concentrations of PTX in tumor tissues in vivo, with no significant adverse subsequences on body weight observed.
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PMC11682224
COX-2 (cyclooxygenase-2) is a key inflammatory mediator enzyme, and the overexpression of COX-2 promotes tumourigenesis and development.
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PMC11655536
B Statistical analysis of Edu positive cells of RPMI-8226 (upper) and U266 (lower).
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PMC7709199
Clear electron density for the glycan chains was observed in all three Ig domains at residues Asn666, Asn710, Asn748 and Asn795.
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PMC11519788
We further explored the effects of SPOP in UBC cells on cytokine/chemokine expression in macrophage.
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PMC10936243
But, usually after surgery such as neutering, usually we will not, because sometimes they are not so in painful condition, I mean in my opinion…” [D122]. “
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PMC11761919
Quantification of seral ALB. (
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PMC11612794
We observed a significant reduction in GFP-Dsn1 levels in the mitotic kinetochores of CENP-C/CENP-T cells compared to those of CENP-C/CENP-T cells (Figures 3F and 3G), and Mis12C did not co-precipitate with CENP-T (Figure 3H).
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PMC11538390
Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article.
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PMC11531735
MDA MB 231-NOS; 4.
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PMC10671321
But, most of the variants are point mutations in either one of these domains.
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PMC4395774
Because these animals were a small portion of all recipients (less than 1/3 of transplanted animals), we were not able to define a threshold of benefit more precisely.
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PMC10470467
Next, we separately performed correlation analysis between key genes, immune checkpoints, and clinical features, and the high prognosis value genes were performed for further analysis.
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PMC9429973
After two TPE sessions antibody titers remained unchanged (TPE1 pre: 2.63 units, TPE1 after:2.19 units, TPE2 pre:2.51 units, TPE2 after:5.52 units).
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PMC11727062
Furthermore, this review elucidated the mechanisms underlying their role in melanoma retention.
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PMC3730428
SMCs are known to promote formation of TNFR complex IIa and b and the ripoptosome, all of which are potentially activating platforms for the initiator caspase, procaspase 8.
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PMC11759543
After incubation with horseradish peroxidase-conjugated secondary antibody, blots were detected using an ECL detection reagent (Thermo scientific or Michigan Diagnostics).
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PMC11790599
Tanshinlactone induces a dysfunctional macropinocytotic process in breast cancer cell lines SK-BR-3 and ZR-75-1. (
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PMC11676169
Whereas control and BCAT1-depleted CCRF-CEM cells exhibited similar rates of ATM phosphorylation, DNA-PK was subject to an accelerated phosphorylation that reached a similar maximum as the control cells but at an earlier time point (8 h vs. 24 h; Figure 3C).
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PMC11779960
In line with this, Iyer et al. recently challenged the mature T cell origin hypothesis of PTCL (Fig. 1b).
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PMC11684821
It was also important to extend the safety testing already performed with the MC.7.G5 (18) and MC.27.759S (Figure 2, F and G) TCRs.
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PMC8759873
Centrifuge at l4000 rpm, 4 C for 10 min, discard the supernatant.
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PMC5173112
USP21 protein expression was detected by Western blot in 786-O cells treated with either control siRNA or USP21 siRNA.
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PMC9512971
Between November 2020 and March 2021, a total of 161 patients provided consent and 155 patients were randomized across 21 participating institutions: 78 to camostat mesilate and 77 to placebo (Fig. 1 and Additional file 2: Table S6).
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PMC11748618
Taken together, these results suggest the chromosome 1 signal is associated with increased CHD1L expression and support prior in vitro results that suggested increasing CHD1L decreases HIV replication.
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PMC9985266
In addition, Gao et al. showed that MEG3 attenuates nickel oxide nanoparticle (NiO NP)-induced PF through regulation of Hedgehog signaling pathway-mediated autophagy.
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PMC6799808
First, to assess the antiproliferative effect of GLPT on tumor cells, human A549 and A427 lung cancer cells were incubated with GLPT (0–1 mg/ml) for 3 or 5 days and then enumerated.
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PMC11783017
In a preliminary study, it was found that by modifying the specific peptide of IL11Rα onto the oxidoreductive responsive polymer vesicles loaded with doxorubicin (IL11-PDox), the specificity and therapeutic efficacy against OS were successfully enhanced .
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