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OTAR3088
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BioData-CellLine_annotated

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PMC11529598
Here, our data revealed that another miRNA, miR-3154, binds directly to 3’UTR of TP53INP1.
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PMC11575040
Overexpression of CD276 enhances melanoma cell migration, invasion, and glycolysis, while its knockdown reduces these capabilities and increases sensitivity to chemotherapy .
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PMC11745823
Upon entering the logarithmic growth phase, characterised by vigorous cell division, the used cells were resuspended and seeded onto 96‐well plates (5 × 10 cells/well).
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PMC11724582
Because of the difficulty in collecting EGFR T790M-mutant NSCLC tissue samples, we selected TGF-β1 as the CAF activator.
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PMC11502327
As an important tool for intracellular communication in vivo, the unique bilayer phospholipid structure of MVS can effectively protect chemotherapy drugs in MVS from being metabolized before reaching the tumor site.
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PMC11661024
The fragments were amplified in a BioRAD Thermocycler (USA) using the following circumstances: 94 °C for 2 min, 30 cycles of 94 °C for 40 s, 50 °C for 30 s, and finally, 72 °C for 10 min.
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PMC4270159
One-way ANOVA. •
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PMC11538390
Sex was not considered in the study design as the phenotype of interest does not apply to only one sex.
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PMC8414691
The ISWI remodeler (negative control) was not detected Localization of SRCAP on midbodies isolated from HeLa cells.
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PMC11186948
The yields of final libraries were assessed by Qubit 4.0 fluorimeter, and their sizes were measured by Agilent Bioanalyzer.
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PMC11371747
Mean values were calculated from standard curves and expressed relative to the housekeeping gene GAPDH.
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PMC9100622
In this regard, it has been shown that RHOA is the direct geranylgeranylated effector signaling to the YAP/TAZ pathway , which plays important roles in the tumorigenesis of Ewing sarcoma (for a review, see ).
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PMC9776316
To better understand the link between the NHEJ pathway and its contribution to cisplatin resistance in ovarian cancer, we performed an NHEJ pathway-focused RNAi screen using a customized lentiviral short-hairpin RNA (shRNA) library.
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PMC11502327
The results showed that TP-EXOS could block OC cells in the S phase, and the effect of inhibiting the proliferation of SKOV-3 cells was two times higher than that of carrier-free TP therapy.
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PMC10142392
Controlling the molecular weight becomes increasingly necessary for polymers that exhibit crystalline behavior, such as polycaprolactone (PCL), which exhibits an amorphous character as long as the polymeric chain is short, thereby enhancing hydrophobic interactions between the polymer and the encapsulated drug .
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PMC10994876
We compared the cell-cycle profiles between the EPO-CHO cell line overexpressing YAP5SA and the control EPO-CHO cells.
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PMC11791478
Taken together, these data indicate that 25A3 does not interfere with the coagulation pathway.
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PMC11680578
Blood vessels in 7-day-old chicken eggs treated with PTX, RGZ, and their combination.
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PMC9812014
The IC50 concentrations of berberine against HSV-I and II were 8.2 ± 1.2 × 10 and 8.2 ± 1.2 × 10 mg/mL respectively and the CC50 concentration of berberine was 13.2 ± 1.6 mg/mL for Vero cells .
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PMC9847912
For all three isolates, the final MOI differed from the one listed above by a factor of 3.0 or less.
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PMC9221284
The translation of this mRNA predicts c-Myc2 protein in agreement with previously described data and with the results that were obtained by Western blot (Figure 2B).
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PMC10965680
The most prominent candidate genes identified in this study are involved in crucial aspects of goat life, including reproduction (CCSER1, PDGFRB, IFT88, LRP1B, STAG1, and SDCCAG8), immunity (DOCK8, IL1R1, and IL7), lactation and milk production (SPP1, TLL1, and ERBB4), hair growth (CHRM2, SDC1, ITCH, and FGF12), and th...
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PMC11628904
Scale bar = 500 μm (whole larvae) and 50 μm (inset). (
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PMC11707577
Transcription levels of E) HySOD and Hsp70, and F) HyCasp‐3 and HyBcl2 genes.
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PMC11342785
The DDX4-CORE synMAP (EC50∼ 1.47 μM) produced bundles that closely resembled those seen for TPPP-FL, creating densely packed structures in which multiple MTs were aligned together (Fig. 2D).
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PMC9368503
RNA was extracted from J000104314 tissue and ICR-SS-1 cells using RNeasy mini and QIAshredder kits (Qiagen, Germantown, MD, USA), following the manufacturer’s instructions, and used to generate cDNA via a Superscript III kit (Invitrogen).
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PMC11545737
GSDMD and caspase-1 were activated in THP-1 macrophages exposed to OMVs from the gastrointestinal resident bacterium Desulfovibrio fairfieldensis, resulting in the secretion of IL-1β along with several other cytokines.
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PMC9031474
Antiproliferative effects of 9-epipolygodial (49) and the Wittig derivative 64 were investigated more intensively .
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PMC6948907
All other chemicals were obtained from the best sources available.
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PMC9429973
Similarly, in the subgroup of MDS patients who achieved CR/CRi, ELN 2017 was predictive of RFS (p=<0.001), but this effect was not sustained in multivariable analysis.
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PMC11225860
The 1mM alisertib groups showed a higher proportion of G2 to G1 cell population at day three (G1 16% and G2 25%) and day five (G1 14% and G2 21%).
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PMC7504302
Consistent with their preceding report, Christensen et al. later noted that the global methylome profiles could effectively differentiate the normal pleura tissue from the malignant state and that they were predictors of patient survival .
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PMC7171147
Our study showed that a blockade of CD36, a fatty acid transporter known to drive FAO, did not affect FAO in the presence of COL11A1, suggesting that CD36-mediated fatty acid uptake only minimally supports FAO in ovarian cancer cells that reside in the COL11A1-rich microenvironment.
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PMC10243817
Control participants were those undergoing septoplasty because of anatomic variations and did not have other sinonasal diseases.
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PMC11320084
GraphPad Prism 6.0 software was used to analyze the results, and the experimental data are expressed as mean ± standard deviation.
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PMC9429973
23/66 pts (34.8%) had high-risk disease (defined as presence of TP53 mutation/deletion, blastoid or pleomorphic variant MCL, or Ki67%/MiB-1 ≥30%).
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PMC10092581
Reagent grade solvents (VWR, Sigma Chemical Co.) were always used as received unless otherwise stated.
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PMC11747949
All experimental procedures conformed to Directive 2010/63/EU requirements and were approved by the Lithuanian State Food and Veterinary Service (Approval No. G2‐233, 2023‐01‐18).
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PMC11612508
The data was presented as the average ± standard deviation from the trio of experiments.
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PMC9429973
Sequencing results also helped clarify the diagnosis in 4 patients (e.g., truncated SOCS1 in DLBCL and ETV3-NCOA2 fusion in indeterminate cell histiocytosis) and led to medical genetics referrals in 3 patients (BRCA2, MSH6, and VHL mutations).
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PMC6643347
Studies of anti-HIV activity To determine the antiviral activity, the cells were incubated at variable concentrations of SBF-HS (10, 1, 0.1, and 0.01 μg/ml) at 37°C in 96-well microtiter plates (Corning, USA) for 2 h. The virus was then inoculated at a multiplicity of infection of 100 TCID50.
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PMC11064533
The aim was to get a clearer picture of the differential expression of proteins involved in sessile and planktonic populations.
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PMC9429973
Thus, mutations in the BTK gene leading to an amino acid substitution at position C481 were found in 59% of Russian pts with CLL treated with ibrutinib.
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PMC5025404
They didn’t aggregate, their doubling was typical for CHO cells (23–35 h).
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PMC11637284
Multiple sequence alignments (msa) were calculated with the R (version 4.3.2) package msa (version 1.36.1) from Bioconductor (version 3.17) and visualized as sequence logos (Fig 3A and 3B) or as an msa (S4 Fig) using the ggseqlogo (version 0.2) and ggmsa (Bioconductor, version 1.10.0) packages, respectively.
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PMC10158546
Lentiviral-transduced ReN cell lines were produced that overexpress the mouse, hamster and human 129M and 129V versions of PrP. Lysate from proliferating ReN progenitor cell lines was western blotted for PrP using the 6H4 (recognizes mouse and human PrP) and 3F4 (recognizes hamster and human PrP) monoclonal antibodies.
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PMC9428827
TILs were evaluated as percentages of CD8 or CD4CD25Foxp3 T lymphocytes from the total number of CD45 cells, and the ratio between percentages is shown ( Figure 3C ).
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PMC11352666
Treatment with MRX-2843 decreased phosphorylation of MERTK in a dose-dependent manner in A673 and TC106 cells (Figure 4B), with IC50 values of 13.3 nM (95% C.I.; 8.3–17.9 nM) and 34.5 nM (95% C.I.; 13.3–119.7 nM), respectively (Figure 4C).
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PMC7642379
Pathways related to retinol, linoleate and nucleotide metabolism were also significantly down-regulated in suspension cell-lines.
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PMC11477621
HRMS (ESI), m/z: calcd for C11H15N2O3: 223.1088 [M − H]; found: 223.1085.
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PMC9429973
These first HSP110 inhibitors have given us the opportunity to gain more insight into the signaling pathways controlled by HSP110 in DLBCL in vitro and in vivo.
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PMC11464982
In the first experiment, cells were exposed to the food enzyme and scored for the frequency of cells with micronuclei at concentrations of 988, 2222 and 5000 μg TOS/mL in a short‐term treatment (3 h exposure and 21 h recovery period) either with or without S9‐mix.
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PMC6163708
As shown in Figure 4, the sensitive SK-MEL-3 cells were inhibited by cylopamine and GANT61 extensively.
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PMC8427838
p < 0.001 Having established a functional link between TMIGD1 and moesin, we asked whether expression profiles of the TMIGD1 and ERM family proteins, moesin and ezrin, correlate with survival of renal cell carcinoma (RCC) patients.
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PMC9429973
Immunocompetent patients aged 18–75 years with newly diagnosed B-cell PVRL were eligible.
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PMC11802855
After 6 days, the CXCL7-OE group showed a higher number of multinucleated osteoclasts, indicating that CXCL7 promotes osteoclast differentiation.
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PMC9368503
Using the SK-UT-1 leiomyosarcoma cells as a human cell line control and NIH-3T3 cells as a murine cell line control, we show that ICR-SS-1 only expressed the human and not the murine version of PTGER2 (Figure 2B), confirming that this cell line is comprised of a pure population of human cells.
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PMC11718109
Ultrathin sections (50–60 nm) were observed in Talos L120C TEM microscope at 80 kV. Images were taken with Velox software and a 4k × 4 K Ceta CMOS Camera (Thermo Fischer Scientific).
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PMC11704834
To test this possibility, Bit1 expression in the mitochondria of A549 cells was targeted via transfection with a C-terminally myc-tagged Bit1 (Bit1 mito) or empty vector plasmid followed by treatment with or without gefitinib.
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PMC11049294
The aim of this work was to develop a fast, flow cytometry-based, less labor-intensive AGAL activity method which is widely applicable.
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PMC11429241
The gene expression evaluation showed that the A2780 cell line exhibited substantial changes in CDH1, CDH2, TWIST, COL1A1, and SMAD3 gene expression, while the SKOV3 cell line had slight changes in said gene expression.
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PMC6222635
In addition, the signals from 1.84 to 2.11 should be assigned to the hydrogen of the methyl of the acetoxy group.
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PMC9429973
For the first time, a large real-world evidence study describes their incorporation in clinical practice in Spain.
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PMC9429973
Global heart T2* values tended to be lower in patients with heart failure than in patients free of heart failure, but the difference was not significant (30.44±14.53 vs 38.24±8.63 ms; P=0.077).
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PMC10158546
Nuclei were counterstained with DAPI (Blue).
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PMC9429973
Summary/Conclusion: In conclusion, daratumumab can lead to CR2 in relapse/refractory ALL, however, the effect is often temporary.
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PMC9927933
After Ad-Cre administration to activate Kras and delete Ube2c alone or in combination with Deptor, we performed IB analysis of mouse lung tissues and confirmed DEPTOR accumulation in Kras(+)Ube2c;Deptor, and DEPTOR depletion in Kras(+)Ube2c;Deptor mice (Supplemental Figure 7A).
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PMC9429973
PET response was assessed according to the revised response criteria for malignant lymphoma and by the Deauville score (DS) 5-point scale.
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PMC6461034
Centrifuge 30 s at 2,000 × g, transfer supernatant (eluate 1) to a 1.5‐ml LoBind Eppendorf tube.
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PMC9429973
The most frequent comorbidities are represented by arterial hypertension and diabetes.
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PMC11472639
PBS was then added to respective wells so that a 200 μL final volume was achieved following the addition of PBMCs or whole blood.
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PMC11033180
The causes of GI symptoms are still unknown but might result from impaired enteric neuronal connectivity, based on the same principle as impaired CNS neuronal connectivity leads to altered behavior.
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PMC11252033
In this research article we demonstrated that the pharmacological or genetic inhibition of CryZ restores the sensitivity to cisplatin in a model of sensitive or resistant ovarian cancer cells.
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PMC9429973
ELN risk and revised MRC prognostic classification at diagnosis were favorable in 8% and 4%, intermediate in 28% and 56%, and adverse in 64% and 40% of the pts, respectively.
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PMC11748363
The influence of R and R substitution on antimycobacterial activity.
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PMC11767725
Comprehensive management strategies that address metabolic dysfunction—through lifestyle modifications, pharmacological interventions like GLP-1 receptor agonists and SGLT-2 inhibitors, and bariatric surgery—can mitigate systemic inflammation and restore microbial homeostasis.
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PMC11637284
All organisms need to segregate their replicated genomes to their daughter cells during cell division.
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PMC8010066
p < 0.05, **: p < 0.001, ***: p < 0.0001.
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PMC11806818
Schematic diagram of the cell sensor and detection principle.
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PMC11786600
Immunostaining analysis confirmed its ability to regulate MMP9, modulate macrophages, and promote neovascularization.
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PMC9429973
.
[ { "tags": [ "O" ], "tokens": [ "." ] } ]
PMC11680982
Intriguingly, further dose reduction to one-fourth (10 mg/kg, low dose) resulted in attenuated efficacy (P < 0.05).
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PMC9895440
n = 6 mice per condition.
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PMC9429973
IMR-261 also showed significant reductions in TSAT, ferritin, GDF15 and erythropoietin, which further support its role in iron homeostasis.
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PMC11766332
For each glycogene nodes of all the regulatory networks reconstructed that showed the highest degrees, we explored the protein function and the related conditions using the Human Protein Atlas database .
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PMC10079526
Proteins were trypsin digested and prepared for LFQ mass spectrometry.
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PMC11700523
CKD is not only the leading cause of end-stage kidney disease but also a significant risk factor for cardiovascular events and mortality.
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PMC5363531
In addition, the combined administration of PEM and dasatinib, as well as the pretreatment with dasatinib, increased the cellular response to PEM.
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PMC11757230
To determine whether the proliferation-inhibitory effect of cADSCs on the canine LL cell lines was dependent on cell-to-cell contact, both cell types were also co-cultured under physical separation using Transwell membranes.
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PMC11547972
Rather, warnings have been issued that excessive amygdalin consumption may lead to severe cyanide poisoning .
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PMC11377827
HIF-1α: control vs. USP43 sgRNA **P = 0.0024, control vs. 14-3-3 siRNA *P = 0.023, control vs. USP43 sgRNA + 14-3-3 siRNA *P = 0.0186.
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PMC9792775
Next, we explored the correlation between BCL-2 and immune cells infiltration since BCL-2 is downstream target gene of JAK2/STAT3 signaling pathway.
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PMC11678130
The impact of the QUE, 5-FU, and QUE+5-FU treatments on the viability of A375 and HaCaT cells was evaluated after 24 h. The cells (1 × 10 cells/well/200 µL complete medium) were grown in 96-well clear plates.
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PMC9268183
As highlighted in previous sections, this study provides compelling evidence regarding the importance of assessing traditional knowledge linked to plants as a possible source of new drugs.
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PMC8839885
Moreover, gene expression of some transporters (ABCC1, ABCC2, ABCC3, and ABCB3) was significantly elevated in recurrent cancer lesions compared with benign or malignant ovarian tissue .
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PMC7759933
From the obtained results, we can see that at the initial density of 3000 cells/spheroid, the distribution of cells by phases does not change over time of cultivation.
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PMC11502327
However, its clinical transformation is often hindered by structural stability, bioavailability, and bioactivity.
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PMC11657744
Their work demonstrated that CEP89 is critical for the assembly of primary cilia in RPE1 cells, specifically by promoting the formation of the ciliary vesicle at the distal appendages of the mother centriole.
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PMC11314247
However, in our study, 54.9% of MCF-7 cells showed apoptosis with HO-AAVPA, which was higher than the percentage reported for VPA .
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PMC9429973
1 SUSAR (persistent GGT elevation) has occurred.
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