OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC9412887	The results indicated that PMONA showed the best inhibitory effect on tumor growth and exhibited the best therapeutic effect with limited side effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11467964	To date, no studies focused on the association between BMRG and STS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "date", ",", "no", "studies", "focused", "on", "the", "associati...
PMC9817179	Using established single-particle tracking (SPT) analysis (Chong et al., 2018), we found the RTs of TAF15(IDR) and TAF15(IDR)-FTH1 to be 10.23 ± 1.10 and 64.15 ± 11.65 s, respectively (Figure 6, Figure 6—source data 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11720808	The stable TLR4-overexpressing 143B cells and wild-type 143B cells were treated with DMSO or SCU (100 μM), and the EdU incorporation assay was used to analyze cell proliferation.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC10506676	Real-time PCR results showed that the expression of E6 (P=0.02) and E7 (P=0.02) genes was considerably increased in HeLa cells containing EBNA1 gene compared to mock plasmid transfected controls (E6 gene expression increased twofold, and E7 gene expression increased thrice).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", ...
PMC9429973	Table 1 shows the response outcomes in detail.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Table", "1", "shows", "the", "response", "outcomes", "in", "detail", "." ] } ]
PMC10858941	Nonetheless, U-251MG cells showed basal detectable HIF-1α expression in normoxia, which similarly decreased by the effect of the drug.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nonetheless", ...
PMC11470999	The potent PF‐interacting protein candidates are shown in Table S2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "potent", "PF‐interacting", "protein", "candidates", "are", "shown", "in", "Table", "S2", ...
PMC3675084	Our results support the previous reports that mutations in β-tubulin and alterations in the expression of class III β-tubulin isotypes induce resistance to microtubule-stabilizing agents and hypersensitivity to microtubule-destabilizing agents through an alteration in the microtubule assembly and dynamics in cancer cel...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11790599	The scale bar is 10 μm. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "scale", "bar", "is", "10", "μm", ".", "(" ] } ]
PMC4695073	Brown staining, XPA positive; blue, cell nucleus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Brown", "staining", ",", "XPA", "positive", ";", "blue", ",", "cell", "nucleus", "." ]...
PMC10994876	Remarkably, the overexpression of YAP5SA in EPO-CHO cells led to a threefold rise in titer compared to control cells, along with a 1.5-fold augmentation in specific productivity (QP).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10938336	Cytoscape version 3.8 was used to construct a compound–target network.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cytoscape", "version", "3.8", "was", "used", "to", "construct", "a", "compound",...
PMC11585254	For CXCR5, the di-leucine motif variant (2L/A) showed a small reduction in internalization (∼25%) in the β-arrestin1/2 DKO cell line (Fig. 5C) but not in the WT HEK293 cell line (Fig. 5 A), suggesting these two modes of internalization may be partially redundant, but that CXCR5 mainly follows a di-leucine and β-arresti...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7171147	Further analysis of TMA revealed that tumor epithelial cells adjacent to COL11A1-postive stroma showed the strongest CPT1A expression (Fig. 6C, Fig. S7E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC7802142	The NV prepared by extruding stem cells produce 250-fold yield compared with that of exosomes .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "NV", "prepared", "by", "extruding", "stem", "cells",...
PMC11694346	A431 cells were treated with varying concentrations of BT-DNBS (0, 1, 10, 100 μM) for 24 hours.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A431", ...
PMC11380329	= effect for drug a in combination E (cb) = effect for drug b in combination E (da) = effect of drug a alone E (db) = effect of drug b alone CIs (combination indices) (eq. 1) and DRIs obtained using CompuSyn software to analyse OVCAR4 ovarian cell viability inhibition resulting from treatment with the combination of vi...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10813895	DNA methylation is one of the key epigenetic modifications to regulate gene expression without affecting DNA sequences.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DNA", "methylation", "is", "one", "of", "th...
PMC10729469	VIVOQUANT software (inviCRO, Boston, MA) was used to overlay the CT and PET reconstructed images for glucose uptake measurements.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "VIVOQUA...
PMC11291490	The plates were then blocked with PBS-T containing 5% nonfat milk at 37 °C for 1 h. DuPBMCs were seeded into 96-well plates with 1 × 10 cell/well in 100 μL. They were obtained and treated as mentioned above.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9874064	Flow cytometry was used to detect the uptake of NP-Pt-USP1i@Cy5.5 by BEL-7404DPP cells at 0 h, 1 h, 4 h and 7 h.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ],...
PMC11794847	Furthermore, nuclear-cytoplasmic fractionation assay results suggested that HVEM overexpression in T cells decreased FOXA2 in the nucleus and cytoplasm and increased GPT2 in the cytoplasm at protein level.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10507284	As previously reported, TROAP could affect the tumor progression and cell cycle of glioma cells via the Wnt/β‐Catenin signaling pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "previously", ...
PMC10820104	Regions coding for potential secondary metabolites were found on six of these eight contigs (Figure 5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Regions", "coding", "for", "potential", ...
PMC11745823	The c‐Myc initiates the transcription of downstream genes by binding to the E‐box sequence, involving many signalling pathways, such as cell cycle regulation, nucleic acid metabolism, and energy metabolism, among others .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The ORR was 40% (95% CI, 21–61) at a median follow-up of 6.9 mo (range 0.7–8.7).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11532793	Coverage tracks from the human lung adenocarcinoma cell lines data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Coverage", "tracks", "from", "the", "human", "lung", "adenocarcinoma", "cell", "lines", "data", ...
PMC11799978	With the addition of NaHCO3, the promigration effect of CAF CM on 4T1 was reduced.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "With", "the", "addition", "of", "NaHCO3", ","...
PMC11615101	The bar graph shows the fluorescence intensity of TLR-2 expression in RAFLS after knockdown of α-Taxilin compared to the α-Taxilin and NS group. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11334037	A total of 2578 DEGs (1398 downregulated, and 1188 upregulated) were identified by screening GSE225819, including 20 normal samples and 20 GISTs samples with liver metastasis (\|log2FC\| > 1; P < 0.05) (Supplementary Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11144382	However, the responsiveness of the VCAM1 promoter to RA appears to be cell-specific due to the variable distribution, number and combination of silencers and activators between cell types.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5839394	The cytotoxic effect of AgNPs biogenerated by Klebsiella oxytoca DSM 29614 under aerobic (AgNPs-EPS) and anaerobic conditions (AgNPs-EPS) was investigated after 24 h of treatment on two human breast cancer cell lines (SKBR3 and 8701-BC) and three human colon cancer cell lines (HT-29, HCT 116 and Caco-2) by using the MT...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11534377	The chamber slides were mounted in ProLong Gold Antifade Mountant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "chamber", "slides", "were", "mounted", "in", "ProLong", "Gold", "Antifade", "Mountant", ...
PMC11612315	The cells were held at −60 mV. Exendin 9–39 (100 nM) was delivered via either the external (intracellular) or internal (extracellular) solution in the presence of 10 nM CAP externally.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9388315	The flow rate of the mobile phase was 1 ml/min .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "flow", "rate", "of", "the", "mobile", "phase", "was", "1", "ml/min", "." ] } ...
PMC11045125	Importantly, we also showed that treatment of the LMP1-expressing ΔEBNA2 + Myc tumor-derived “B1” cell line (derived from Donor 1) with the Src kinase inhibitor, dasatinib, not only strongly inhibits the level of constitutive STAT3 tyrosine 705 phosphorylation but also decreases LMP1 expression (S8 Fig).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11747885	However, at 31.3 nM hLig1, variations in DNA ligase activity were noted, including the DMSO control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "at", "31.3", ...
PMC11711663	HHL GLSZMSizeZoneNonUniformityNormalized12.	[ { "tags": [ "O", "O", "O" ], "tokens": [ "HHL", "GLSZMSizeZoneNonUniformityNormalized12", "." ] } ]
PMC11026382	That is to say, given that enzymes act sequentially to produce metabolites, the effects of mutations on cellular phenotype can be buffered or amplified depending on which enzymatic reactions control metabolic flux.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11269792	Transfection of si-circAPP alone miR-6838-5p expression, but the action of si-circAPP was impaired by miR-6838-5p inhibitor (Fig. 4A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC8750422	Cells were maintained in RPMI-1640 (Cytiva, Marlborough, MA, USA) medium supplemented with 1% penicillin-streptomycin (Welgene, Gyeongsan, Korea), 1% sodium pyruvate and 10% fetal bovine serum (FBS, Cytiva, Marlborough, MA, USA) at 37 °C in a humidified atmosphere of 5% CO2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767817	Cyclin C-CDK3 complexes are essential for G0/G1 transition, and complexes of CDK4 or CDK6 with one of the D cyclins (D1, D2, and D3) are involved in the G1 phase, while CDK2/1 complexed with cyclin E or cyclin A is essential for the G1/S transition and DNA synthesis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11723947	c Exhaustion signature enrichment analyses of cluster 2 genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "c", "Exhaustion", "signature", "enrichment", "analyses", "of", "cluster", "2", "genes", "." ] } ]
PMC11700340	Heat shock protein 90 is identified as a potent and successful pharmacological target for designing novel anticancer drugs, as it plays a critical role in cell growth .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11791203	The outcomes, including the binding scores, were comprehensively tabulated in Table 5, offering a quantitative assessment of the ligand-protein interactions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11411004	We demonstrated that I-4 has selective inhibitory activity against class I HDACs, particularly HDAC5, mainly because the mRNA and protein expression of HDAC5 decreased significantly in a large-scale screening test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11599565	Moreover, we found that PNMA1-ChgA double positive cells were significantly amplified in the ovarian carcinoma tissues (Fig. 7, Panel D, I-P).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC5839394	Since AgNPs-EPS contains more total silver than AgNPs-EPS and the amount of Ag released from AgNPs-EPS is significantly higher than for AgNPs-EPS , we believe that the biological activity of AgNPs-EPS is Ag-dependent.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11747467	As one of the most common urological malignancies, bladder cancer (BLCA) has approximately 573,278 new cases in 2020, and this number is expected to double by 2040 according to World Health Organization predictions (1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11400680	The major goal of this study is to propose a model, for instance segmentation of cells and nuclei, applying the most cutting-edge deep learning techniques.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11402217	There is still no definitive evidence of DKK1’s effects on OS cell proliferation, differentiation, migration, or its impact on bone integrity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9119314	They received Teklad 2018 diet (Envigo, Blackthorn, United Kingdom) and water ad libitum.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "received", "Teklad", "2018", "diet", ...
PMC10723784	Phosphate‐buffered saline (PBS), Solution 8 (1 μg/mL 4′,6‐diamidino‐2‐phenylindole [DAPI]), Solution 7 (5,5,6,6‐tetrachloro‐1,1,3,3‐tetraethylbenzimidazolcarbocyanine iodide of 200 μg/mL JC‐1), Annexin V binding buffer (10× concentrate), Solution 16 (500 μg/mL Propidium Iodide), Solution 10 (Lysis buffer), Solution 11 ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10530622	Calcium oxalate (CaOx) is the most common compound in kidney stones and is present in different forms, such as CaOx anhydrous, CaOx monohydrate, and CaOx trihydrate .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9398137	We analyzed mechanisms of sensitivity/resistance to S63845 in preclinical models of diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "analyzed", ...
PMC11055323	To this end, we focused on HDAC1, which has N-terminal histone deacetylase and C-terminal disordered region (Supplementary Fig. 8a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", ...
PMC11354239	130-096-831; diluted 100×) for 20 min at 4 °C, followed by flow cytometry analysis using BD FACSAria III Cell Sorter (BD Bioscience).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11648299	Finally, when all patients with either immunosuppressive drugs or retinoids were excluded, the HR for keratinocyte carcinoma was 1.8 (95% CI, 1.0-3.1, P = 0.051) (Fig. 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10988808	The results showed that overexpression of CCDC25 notably inhibited the expression of downstream Hippo pathway proteins ITGA3 and CCND1 but did not affect the expression of the key protein YAP or the proteins LATS1/LATS2, which influence YAP phosphorylation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10975211	There is a significant possibility of improving various approaches to treating cancer thanks to the swift development of nanotechnology and the discovery of nanomedical agents .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11306019	Our research seeks to elucidate the relationship between the structure of polyphenols and their antagonistic effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "research", "seeks", "to", "elucidate", "the", ...
PMC3681794	HIF-1 independent mechanisms of drug resistance in hypoxia are under-investigated and rarely reported.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HIF-1", "independent", "mechanisms", "of", "drug", "resistance", "in", "hyp...
PMC11615828	All DNA constructs were verified through DNA sequencing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "DNA", "constructs", "were", "verified", "through", "DNA", "sequencing", "." ] } ]
PMC11412721	In sum, classical assays for p53 activity in tumors failed to account for differences between the two male genotypes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "sum", ",", "clas...
PMC9429973	No microorganisms were isolated in the microbiological studies and it was suspected that it could be a seizure syndrome.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "microorganisms", "were", "i...
PMC11790971	To bridge this gap, future efforts should aim to increase the speed and scalability of multimodal imaging, potentially through automation or parallelization, while preserving its high-content advantages.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3035438	By knock-in of the human IgG constant region into the chicken IgM heavy-chain locus, we designed DT40 derivatives that express by alternative splicing both chicken IgM and chimeric IgG sharing the same antigen-binding domain.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	We have previously observed that ruxolitinib, a JAK1/2 inhibitor, may alter the epigenetic landscape of histone modifications in MPN.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "have", "pre...
PMC10243817	MEX3B has been demonstrated to impair HLA-A mRNA stability by binding to its 3′ UTR in melanoma cells (12).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MEX3B", "has", "b...
PMC10870498	Besides, silencing of SIRT7 decreased the protein levels of KIF23 and SIRT7, and increased the levels of KIF23-succ in HEK-293T cells (Fig. 3F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "...
PMC10747160	Alternatively, Griffithsin could protect virions from proteases secreted by, or from being phagocytosed by, activated Raji cells, making it appear as though the SARS-CoV-2 pseudovirus infectivity is enhanced by the presence of Griffithsin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", ...
PMC11487720	Post-exposure, cells were subjected to cold shock at 4 or 10 °C for indicated times.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Post-exposure", ",", "cells", "were", "subjected"...
PMC10932641	The diversity of functions of lncRNA is closely associated with their mechanisms of action, spatiotemporal expression, and/or abundance differences (9).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11040965	Differentially methylated CpG sites were identified by a Benjamini–Hochberg adjusted P < 0.05, with no threshold for the methylation difference.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Differe...
PMC8540692	However, the simultaneous treatment with both CCM and NaBu (the combination treatment) was more cytotoxic than single treatments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "t...
PMC11252553	While taurine does not directly scavenge Reactive Oxygen Species (ROS), it exerts a significant inhibitory effect on ROS generation, effectively reducing their levels in biological systems .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11291490	BHK-21 cells were maintained in Dulbecco’s modified Eagle medium (DMEM, Gibco, USA) supplemented with 10% new bovine serum (NBS, Gibco, USA).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11535726	Mycelium semi-immersed, on the substrate, pale brown to dark brown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mycelium", "semi-immersed", ",", "on", "the", "substrate", ",", "pale", "brown",...
PMC11040965	The human U266 and RPMI 8226 myeloma cell lines (U266B1, CVCL_0566; RPMI-8226, CVCL_0014) were obtained from the American Type Culture Collection (ATCC) and cultured in RPMI-1640 medium supplemented with 10% fetal bovine serum (FBS), 2 mM L-glutamine, 100 U/mL penicillin, and 100 μg/mL streptomycin (all from Sigma-Aldr...	[ { "tags": [ "O", "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612315	The mice were housed at a constant temperature and humidity under a 12-h/12-h light‒dark cycle with free access to standard food and water for at least 1 week prior to the beginning of the experimental procedures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11025866	These results show that VPM selectively regulates a smaller subset of cellular genes than does VPA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "show", "that", "VPM", "selectively...
PMC9985266	The lung tissue status was observed by Masson and hematoxylin and eosin (HE) staining.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "lung", "tissue", "status", "was", "observed", ...
PMC9429973	L. Chang, L. zhang, W. An, Y. wan, Y. cai, Y. Lan, M. Ruan, X. liu, Y. Zou, X. Zhu State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Un...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11683240	H–I, binding IC50 values were calculated from median fluorescence intensities for experiments without (I, H) and with (E, I) the preincubation of 488-labeled PT and different concentrations α1AT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11531735	In a previous study, we reported the effectiveness of ER121, a structurally resolved small compound specifically designed to target human cancers expressing or overexpressing mutant EGFR and HER2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8875242	Elbasvir also inhibited ABCB1 in vitro , but its effect on intestinal ABCB1 inhibition appears to be minimal in humans (11% increase in plasma AUC) , which is consistent with its lack of effect in our hPCIS experiments (Figure 2B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10142392	In this case, several factors such as drug solubility, drug affinity for the polymer, nanoparticle core volume, and drug self-aggregation capacity can influence the drug loading capacity (DLC), which is the mass ratio of drug to polymer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11732523	December 22, 2023: The images show multiple patchy and linear ground-glass opacities in both lungs, with increased density in dorsal regions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11763126	Furthermore, Zhang et al. explored human ccRCC using peptidomics and discovered a new endogenous peptide called Tat-hspb1, which originates from the HSPB1 protein, with potential therapeutic implications for renal cancer .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11088135	A MTT assay was conducted to assess the cell proliferation of U251 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "A", "MTT", "assay", "was", "conducted", "to", "assess", "the", ...
PMC10938336	Furthermore, the integration of network pharmacology approaches with molecular docking analyses offered a comprehensive view on the therapeutic potential of these curcuminoid analogues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC3035438	The IC50 is correlated to the dissociation constant of the antibody.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "IC50", "is", "correlated", "to", "the", "dissociation", "constant", "of", "the...
PMC9429973	Despite the significant innovation in therapeutics of hematological malignancies, little progress is made in these lymphomas management.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Despite", "the", "significant", "innovation"...
PMC9429973	Best molecular response to previous TKIs, molecular response at the time of asciminib starting, number of TKIs prior to asciminib, and history of previous ponatinib treatment were identified as predictors of MMR at 12 months (Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11082662	Importantly, we also proved that downregulation of SMPDL3B inhibited the proliferation, migration, and invasion of ovarian carcinoma cells, suggesting that SMPDL3B may be a novel target for ovarian carcinoma treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O"...
PMC9429973	Patients who received rescue medication discontinued from the study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "who", "received", "rescue", "medication", "discontinued", "from", "the", "study", "." ] }...
PMC9429973	SF3B1 showed an average variant allelic frequency (VAF) of 41%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SF3B1", "showed", "an", "average", "variant", "allelic", "frequency", "(", ...
PMC11337594	Differentially expressed genes (TER2.0 µg/ml vs. control, n = 3) were enriched for “Mitotic DNA integrity Checkpoint” as established by GESA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9268620	The cells were harvested, washed with PBS, and fixed with 4% buffered glutaraldehyde for 12 to 24 h at 4 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC9412887

The results indicated that PMONA showed the best inhibitory effect on tumor growth and exhibited the best therapeutic effect with limited side effects.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...

PMC11467964

To date, no studies focused on the association between BMRG and STS.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "date", ",", "no", "studies", "focused", "on", "the", "associati...

PMC9817179

Using established single-particle tracking (SPT) analysis (Chong et al., 2018), we found the RTs of TAF15(IDR) and TAF15(IDR)-FTH1 to be 10.23 ± 1.10 and 64.15 ± 11.65 s, respectively (Figure 6, Figure 6—source data 1).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11720808

The stable TLR4-overexpressing 143B cells and wild-type 143B cells were treated with DMSO or SCU (100 μM), and the EdU incorporation assay was used to analyze cell proliferation.

[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...

PMC10506676

Real-time PCR results showed that the expression of E6 (P=0.02) and E7 (P=0.02) genes was considerably increased in HeLa cells containing EBNA1 gene compared to mock plasmid transfected controls (E6 gene expression increased twofold, and E7 gene expression increased thrice).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", ...

PMC9429973

Table 1 shows the response outcomes in detail.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Table", "1", "shows", "the", "response", "outcomes", "in", "detail", "." ] } ]

PMC10858941

Nonetheless, U-251MG cells showed basal detectable HIF-1α expression in normoxia, which similarly decreased by the effect of the drug.

[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nonetheless", ...

PMC11470999

The potent PF‐interacting protein candidates are shown in Table S2.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "potent", "PF‐interacting", "protein", "candidates", "are", "shown", "in", "Table", "S2", ...

PMC3675084

Our results support the previous reports that mutations in β-tubulin and alterations in the expression of class III β-tubulin isotypes induce resistance to microtubule-stabilizing agents and hypersensitivity to microtubule-destabilizing agents through an alteration in the microtubule assembly and dynamics in cancer cel...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11790599

The scale bar is 10 μm. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "scale", "bar", "is", "10", "μm", ".", "(" ] } ]

PMC4695073

Brown staining, XPA positive; blue, cell nucleus.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Brown", "staining", ",", "XPA", "positive", ";", "blue", ",", "cell", "nucleus", "." ]...

PMC10994876

Remarkably, the overexpression of YAP5SA in EPO-CHO cells led to a threefold rise in titer compared to control cells, along with a 1.5-fold augmentation in specific productivity (QP).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10938336

Cytoscape version 3.8 was used to construct a compound–target network.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cytoscape", "version", "3.8", "was", "used", "to", "construct", "a", "compound",...

PMC11585254

For CXCR5, the di-leucine motif variant (2L/A) showed a small reduction in internalization (∼25%) in the β-arrestin1/2 DKO cell line (Fig. 5C) but not in the WT HEK293 cell line (Fig. 5 A), suggesting these two modes of internalization may be partially redundant, but that CXCR5 mainly follows a di-leucine and β-arresti...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7171147

Further analysis of TMA revealed that tumor epithelial cells adjacent to COL11A1-postive stroma showed the strongest CPT1A expression (Fig. 6C, Fig. S7E).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC7802142

The NV prepared by extruding stem cells produce 250-fold yield compared with that of exosomes .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "NV", "prepared", "by", "extruding", "stem", "cells",...

PMC11694346

A431 cells were treated with varying concentrations of BT-DNBS (0, 1, 10, 100 μM) for 24 hours.

[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A431", ...

PMC11380329

= effect for drug a in combination E (cb) = effect for drug b in combination E (da) = effect of drug a alone E (db) = effect of drug b alone CIs (combination indices) (eq. 1) and DRIs obtained using CompuSyn software to analyse OVCAR4 ovarian cell viability inhibition resulting from treatment with the combination of vi...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10813895

DNA methylation is one of the key epigenetic modifications to regulate gene expression without affecting DNA sequences.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DNA", "methylation", "is", "one", "of", "th...

PMC10729469

VIVOQUANT software (inviCRO, Boston, MA) was used to overlay the CT and PET reconstructed images for glucose uptake measurements.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "VIVOQUA...

PMC11291490

The plates were then blocked with PBS-T containing 5% nonfat milk at 37 °C for 1 h. DuPBMCs were seeded into 96-well plates with 1 × 10 cell/well in 100 μL. They were obtained and treated as mentioned above.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9874064

Flow cytometry was used to detect the uptake of NP-Pt-USP1i@Cy5.5 by BEL-7404DPP cells at 0 h, 1 h, 4 h and 7 h.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ],...

PMC11794847

Furthermore, nuclear-cytoplasmic fractionation assay results suggested that HVEM overexpression in T cells decreased FOXA2 in the nucleus and cytoplasm and increased GPT2 in the cytoplasm at protein level.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10507284

As previously reported, TROAP could affect the tumor progression and cell cycle of glioma cells via the Wnt/β‐Catenin signaling pathway.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "previously", ...

PMC10820104

Regions coding for potential secondary metabolites were found on six of these eight contigs (Figure 5).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Regions", "coding", "for", "potential", ...

PMC11745823

The c‐Myc initiates the transcription of downstream genes by binding to the E‐box sequence, involving many signalling pathways, such as cell cycle regulation, nucleic acid metabolism, and energy metabolism, among others .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

The ORR was 40% (95% CI, 21–61) at a median follow-up of 6.9 mo (range 0.7–8.7).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...

PMC11532793

Coverage tracks from the human lung adenocarcinoma cell lines data.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Coverage", "tracks", "from", "the", "human", "lung", "adenocarcinoma", "cell", "lines", "data", ...

PMC11799978

With the addition of NaHCO3, the promigration effect of CAF CM on 4T1 was reduced.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "With", "the", "addition", "of", "NaHCO3", ","...

PMC11615101

The bar graph shows the fluorescence intensity of TLR-2 expression in RAFLS after knockdown of α-Taxilin compared to the α-Taxilin and NS group. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11334037

A total of 2578 DEGs (1398 downregulated, and 1188 upregulated) were identified by screening GSE225819, including 20 normal samples and 20 GISTs samples with liver metastasis (|log2FC| > 1; P < 0.05) (Supplementary Table 1).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11144382

However, the responsiveness of the VCAM1 promoter to RA appears to be cell-specific due to the variable distribution, number and combination of silencers and activators between cell types.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC5839394

The cytotoxic effect of AgNPs biogenerated by Klebsiella oxytoca DSM 29614 under aerobic (AgNPs-EPS) and anaerobic conditions (AgNPs-EPS) was investigated after 24 h of treatment on two human breast cancer cell lines (SKBR3 and 8701-BC) and three human colon cancer cell lines (HT-29, HCT 116 and Caco-2) by using the MT...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11534377

The chamber slides were mounted in ProLong Gold Antifade Mountant.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "chamber", "slides", "were", "mounted", "in", "ProLong", "Gold", "Antifade", "Mountant", ...

PMC11612315

The cells were held at −60 mV. Exendin 9–39 (100 nM) was delivered via either the external (intracellular) or internal (extracellular) solution in the presence of 10 nM CAP externally.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9388315

The flow rate of the mobile phase was 1 ml/min .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "flow", "rate", "of", "the", "mobile", "phase", "was", "1", "ml/min", "." ] } ...

PMC11045125

Importantly, we also showed that treatment of the LMP1-expressing ΔEBNA2 + Myc tumor-derived “B1” cell line (derived from Donor 1) with the Src kinase inhibitor, dasatinib, not only strongly inhibits the level of constitutive STAT3 tyrosine 705 phosphorylation but also decreases LMP1 expression (S8 Fig).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11747885

However, at 31.3 nM hLig1, variations in DNA ligase activity were noted, including the DMSO control.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "at", "31.3", ...

PMC11711663

HHL GLSZMSizeZoneNonUniformityNormalized12.

[ { "tags": [ "O", "O", "O" ], "tokens": [ "HHL", "GLSZMSizeZoneNonUniformityNormalized12", "." ] } ]

PMC11026382

That is to say, given that enzymes act sequentially to produce metabolites, the effects of mutations on cellular phenotype can be buffered or amplified depending on which enzymatic reactions control metabolic flux.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11269792

Transfection of si-circAPP alone miR-6838-5p expression, but the action of si-circAPP was impaired by miR-6838-5p inhibitor (Fig. 4A).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC8750422

Cells were maintained in RPMI-1640 (Cytiva, Marlborough, MA, USA) medium supplemented with 1% penicillin-streptomycin (Welgene, Gyeongsan, Korea), 1% sodium pyruvate and 10% fetal bovine serum (FBS, Cytiva, Marlborough, MA, USA) at 37 °C in a humidified atmosphere of 5% CO2.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11767817

Cyclin C-CDK3 complexes are essential for G0/G1 transition, and complexes of CDK4 or CDK6 with one of the D cyclins (D1, D2, and D3) are involved in the G1 phase, while CDK2/1 complexed with cyclin E or cyclin A is essential for the G1/S transition and DNA synthesis .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11723947

c Exhaustion signature enrichment analyses of cluster 2 genes.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "c", "Exhaustion", "signature", "enrichment", "analyses", "of", "cluster", "2", "genes", "." ] } ]

PMC11700340

Heat shock protein 90 is identified as a potent and successful pharmacological target for designing novel anticancer drugs, as it plays a critical role in cell growth .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11791203

The outcomes, including the binding scores, were comprehensively tabulated in Table 5, offering a quantitative assessment of the ligand-protein interactions.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...

PMC11411004

We demonstrated that I-4 has selective inhibitory activity against class I HDACs, particularly HDAC5, mainly because the mRNA and protein expression of HDAC5 decreased significantly in a large-scale screening test.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11599565

Moreover, we found that PNMA1-ChgA double positive cells were significantly amplified in the ovarian carcinoma tissues (Fig. 7, Panel D, I-P).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC5839394

Since AgNPs-EPS contains more total silver than AgNPs-EPS and the amount of Ag released from AgNPs-EPS is significantly higher than for AgNPs-EPS , we believe that the biological activity of AgNPs-EPS is Ag-dependent.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11747467

As one of the most common urological malignancies, bladder cancer (BLCA) has approximately 573,278 new cases in 2020, and this number is expected to double by 2040 according to World Health Organization predictions (1).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11400680

The major goal of this study is to propose a model, for instance segmentation of cells and nuclei, applying the most cutting-edge deep learning techniques.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11402217

There is still no definitive evidence of DKK1’s effects on OS cell proliferation, differentiation, migration, or its impact on bone integrity.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC9119314

They received Teklad 2018 diet (Envigo, Blackthorn, United Kingdom) and water ad libitum.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "received", "Teklad", "2018", "diet", ...

PMC10723784

Phosphate‐buffered saline (PBS), Solution 8 (1 μg/mL 4′,6‐diamidino‐2‐phenylindole [DAPI]), Solution 7 (5,5,6,6‐tetrachloro‐1,1,3,3‐tetraethylbenzimidazolcarbocyanine iodide of 200 μg/mL JC‐1), Annexin V binding buffer (10× concentrate), Solution 16 (500 μg/mL Propidium Iodide), Solution 10 (Lysis buffer), Solution 11 ...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10530622

Calcium oxalate (CaOx) is the most common compound in kidney stones and is present in different forms, such as CaOx anhydrous, CaOx monohydrate, and CaOx trihydrate .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9398137

We analyzed mechanisms of sensitivity/resistance to S63845 in preclinical models of diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "analyzed", ...

PMC11055323

To this end, we focused on HDAC1, which has N-terminal histone deacetylase and C-terminal disordered region (Supplementary Fig. 8a).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", ...

PMC11354239

130-096-831; diluted 100×) for 20 min at 4 °C, followed by flow cytometry analysis using BD FACSAria III Cell Sorter (BD Bioscience).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11648299

Finally, when all patients with either immunosuppressive drugs or retinoids were excluded, the HR for keratinocyte carcinoma was 1.8 (95% CI, 1.0-3.1, P = 0.051) (Fig. 3).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10988808

The results showed that overexpression of CCDC25 notably inhibited the expression of downstream Hippo pathway proteins ITGA3 and CCND1 but did not affect the expression of the key protein YAP or the proteins LATS1/LATS2, which influence YAP phosphorylation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10975211

There is a significant possibility of improving various approaches to treating cancer thanks to the swift development of nanotechnology and the discovery of nanomedical agents .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11306019

Our research seeks to elucidate the relationship between the structure of polyphenols and their antagonistic effects.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "research", "seeks", "to", "elucidate", "the", ...

PMC3681794

HIF-1 independent mechanisms of drug resistance in hypoxia are under-investigated and rarely reported.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HIF-1", "independent", "mechanisms", "of", "drug", "resistance", "in", "hyp...

PMC11615828

All DNA constructs were verified through DNA sequencing.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "DNA", "constructs", "were", "verified", "through", "DNA", "sequencing", "." ] } ]

PMC11412721

In sum, classical assays for p53 activity in tumors failed to account for differences between the two male genotypes.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "sum", ",", "clas...

PMC9429973

No microorganisms were isolated in the microbiological studies and it was suspected that it could be a seizure syndrome.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "microorganisms", "were", "i...

PMC11790971

To bridge this gap, future efforts should aim to increase the speed and scalability of multimodal imaging, potentially through automation or parallelization, while preserving its high-content advantages.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC3035438

By knock-in of the human IgG constant region into the chicken IgM heavy-chain locus, we designed DT40 derivatives that express by alternative splicing both chicken IgM and chimeric IgG sharing the same antigen-binding domain.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

We have previously observed that ruxolitinib, a JAK1/2 inhibitor, may alter the epigenetic landscape of histone modifications in MPN.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "have", "pre...

PMC10243817

MEX3B has been demonstrated to impair HLA-A mRNA stability by binding to its 3′ UTR in melanoma cells (12).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MEX3B", "has", "b...

PMC10870498

Besides, silencing of SIRT7 decreased the protein levels of KIF23 and SIRT7, and increased the levels of KIF23-succ in HEK-293T cells (Fig. 3F).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "...

PMC10747160

Alternatively, Griffithsin could protect virions from proteases secreted by, or from being phagocytosed by, activated Raji cells, making it appear as though the SARS-CoV-2 pseudovirus infectivity is enhanced by the presence of Griffithsin.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", ...

PMC11487720

Post-exposure, cells were subjected to cold shock at 4 or 10 °C for indicated times.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Post-exposure", ",", "cells", "were", "subjected"...

PMC10932641

The diversity of functions of lncRNA is closely associated with their mechanisms of action, spatiotemporal expression, and/or abundance differences (9).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11040965

Differentially methylated CpG sites were identified by a Benjamini–Hochberg adjusted P < 0.05, with no threshold for the methylation difference.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Differe...

PMC8540692

However, the simultaneous treatment with both CCM and NaBu (the combination treatment) was more cytotoxic than single treatments.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "t...

PMC11252553

While taurine does not directly scavenge Reactive Oxygen Species (ROS), it exerts a significant inhibitory effect on ROS generation, effectively reducing their levels in biological systems .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11291490

BHK-21 cells were maintained in Dulbecco’s modified Eagle medium (DMEM, Gibco, USA) supplemented with 10% new bovine serum (NBS, Gibco, USA).

[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11535726

Mycelium semi-immersed, on the substrate, pale brown to dark brown.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mycelium", "semi-immersed", ",", "on", "the", "substrate", ",", "pale", "brown",...

PMC11040965

The human U266 and RPMI 8226 myeloma cell lines (U266B1, CVCL_0566; RPMI-8226, CVCL_0014) were obtained from the American Type Culture Collection (ATCC) and cultured in RPMI-1640 medium supplemented with 10% fetal bovine serum (FBS), 2 mM L-glutamine, 100 U/mL penicillin, and 100 μg/mL streptomycin (all from Sigma-Aldr...

[ { "tags": [ "O", "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11612315

The mice were housed at a constant temperature and humidity under a 12-h/12-h light‒dark cycle with free access to standard food and water for at least 1 week prior to the beginning of the experimental procedures.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11025866

These results show that VPM selectively regulates a smaller subset of cellular genes than does VPA.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "show", "that", "VPM", "selectively...

PMC9985266

The lung tissue status was observed by Masson and hematoxylin and eosin (HE) staining.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "lung", "tissue", "status", "was", "observed", ...

PMC9429973

L. Chang, L. zhang, W. An, Y. wan, Y. cai, Y. Lan, M. Ruan, X. liu, Y. Zou, X. Zhu State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Un...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11683240

H–I, binding IC50 values were calculated from median fluorescence intensities for experiments without (I, H) and with (E, I) the preincubation of 488-labeled PT and different concentrations α1AT.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11531735

In a previous study, we reported the effectiveness of ER121, a structurally resolved small compound specifically designed to target human cancers expressing or overexpressing mutant EGFR and HER2.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8875242

Elbasvir also inhibited ABCB1 in vitro , but its effect on intestinal ABCB1 inhibition appears to be minimal in humans (11% increase in plasma AUC) , which is consistent with its lack of effect in our hPCIS experiments (Figure 2B).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10142392

In this case, several factors such as drug solubility, drug affinity for the polymer, nanoparticle core volume, and drug self-aggregation capacity can influence the drug loading capacity (DLC), which is the mass ratio of drug to polymer.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11732523

December 22, 2023: The images show multiple patchy and linear ground-glass opacities in both lungs, with increased density in dorsal regions.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11763126

Furthermore, Zhang et al. explored human ccRCC using peptidomics and discovered a new endogenous peptide called Tat-hspb1, which originates from the HSPB1 protein, with potential therapeutic implications for renal cancer .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11088135

A MTT assay was conducted to assess the cell proliferation of U251 cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "A", "MTT", "assay", "was", "conducted", "to", "assess", "the", ...

PMC10938336

Furthermore, the integration of network pharmacology approaches with molecular docking analyses offered a comprehensive view on the therapeutic potential of these curcuminoid analogues.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC3035438

The IC50 is correlated to the dissociation constant of the antibody.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "IC50", "is", "correlated", "to", "the", "dissociation", "constant", "of", "the...

PMC9429973

Despite the significant innovation in therapeutics of hematological malignancies, little progress is made in these lymphomas management.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Despite", "the", "significant", "innovation"...

PMC9429973

Best molecular response to previous TKIs, molecular response at the time of asciminib starting, number of TKIs prior to asciminib, and history of previous ponatinib treatment were identified as predictors of MMR at 12 months (Table 1).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11082662

Importantly, we also proved that downregulation of SMPDL3B inhibited the proliferation, migration, and invasion of ovarian carcinoma cells, suggesting that SMPDL3B may be a novel target for ovarian carcinoma treatment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O"...

PMC9429973

Patients who received rescue medication discontinued from the study.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "who", "received", "rescue", "medication", "discontinued", "from", "the", "study", "." ] }...

PMC9429973

SF3B1 showed an average variant allelic frequency (VAF) of 41%.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SF3B1", "showed", "an", "average", "variant", "allelic", "frequency", "(", ...

PMC11337594

Differentially expressed genes (TER2.0 µg/ml vs. control, n = 3) were enriched for “Mitotic DNA integrity Checkpoint” as established by GESA.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC9268620

The cells were harvested, washed with PBS, and fixed with 4% buffered glutaraldehyde for 12 to 24 h at 4 °C.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...