OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC6102174	In addition to anti-HBV efficiency, TCMs can reduce the ALT and AST levels by improving the hepatic function of patients, and relieve HBV-associated clinical symptoms, e.g. anorexia, hypodynamia, nausea and vomiting, to improve the life quality of patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11741906	Fig. 5 Effect of differentially expressed miRNAs related to cisplatin resistance on Pathways in cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "5", "Effect", "of", "differentially", "expressed", ...
PMC8097906	Initial anti-tumor screenings of all substances analyzed in this study, identified the plant extract of Vincetoxicum arnottianum (VSM) as the most promising candidate, harboring the highest anti-metastatic potential.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10932641	After the cryopreservation tube of Renal cancer cell line 786-0 was thawed from the liquid nitrogen tank, the cells were cultured in RPMI1640 complete medium containing 10% FBS and 1% penicillin-streptomycin mixed solution and then placed in a 37 ℃, 5% CO2, saturated humidity incubator.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC11621565	After 72 h, the medium was replaced with differentiation medium, supplemented with 80 nM of phorbole-myristate-acetate (PMA) for another 72 h, after which the medium was changed, and the cells were treated for 48 h with microbial-derived molecules according to the experimental design.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11753949	Regions of interest were sectioned (50–60nm) and imaged using a Talos L120C TEM microscope at 80kV. EM reagents are from EMS, Hatfield, PA unless noted otherwise.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8609870	First, based on the threshold values (r < 0 and p value < 0.05), we evaluated the relationship between downregulated lncRNAs and upregulated miRNAs shown in Fig. 4a, and the relationship between upregulated lncRNAs and downregulated miRNAs was displayed in Additional file 2: Figure S2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11092418	We found that treatments with the targeted agents such as stattic, neratinib, trametinib were more effective than other targeted agents by inhibiting the migration of A172 cells (Fig. 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11412721	Details on the four p53 mutations identified in (D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Details", "on", "the", "four", "p53", "mutations", "identified", "in", "(", "D", ...
PMC11731614	2Isolated extracellular vesicles from SEC fraction 2/3 are functionally retrogradely trafficked by DRG neurons in vitro.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "2Isolated", "extracellular", "vesicles", "from", "SEC", ...
PMC9532503	It can be seen from the figure that the association (ka), dissociation (kd), and binding affinity (KD) of test antibody (P2-CRD-1508) was high in comparison to control antibody (RS-03-25)Table 5SPR kinetic values obtained for FcγRIIIa V158 (A and B) and F158 (C and D) receptors for the test anti-CD20 antibody and contr...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11785489	We approximated each TCR’s affinity to the MART-1 tetramer with EC5, the tetramer concentration at which 5% of Jurkat cells stain positively for tetramer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", ...
PMC11612794	Phosphorylation of the Dsn1 basic motif by Aurora B precludes the mask by inhibiting the basic motif binding to the Nsl1 acidic surface.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Phospho...
PMC11194678	The above observation suggests a potential connection between enlarged cytoplasmic STAU1 puncta and upregulation of STAU1 and mTOR levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "above", "observation", "su...
PMC11740207	Activation of these pathways promotes the early stages of mesodermal development.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Activation", "of", "these", "pathways", "promotes", "the", "early", "stages", "of", "...
PMC11419566	PA is combined with anticancer drugs and radiotherapy to increase the sensitivity of cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PA", "is", "combined", "with", "anticancer", "drugs", "and"...
PMC11228511	In earlier studies (13), we found that overexpression of an inner NM protein, LAP2β, eliminated NM ruptures in LmnaLmnb1Lmnb2 fibroblasts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11757230	Further inquiries can be directed to the corresponding author.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "inquiries", "can", "be", "directed", "to", "the", "corresponding", "author", "." ] } ]
PMC9429973	CRS in all pts was manageable and resolved after treatment with Ruxolitinib, SOC and supportive care.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CRS", "in", "all", "pts", "was", "manageabl...
PMC9429973	Methods: Multicenter, retrospective, observational report of myeloproliferative neoplasms in 13 mexican medical centers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "Multicenter", ",", "retrospective", ",...
PMC11576293	In all cases, these compounds have lower efficacy than compound 22, suggesting that the 4-OMe-benzyl group at position two is critical for the antiproliferative action.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The Lugano response criteria were used to assess disease response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Lugano", "response", "criteria", "were", "used", "to", "assess", "disease", "response", ...
PMC11638255	This technical hurdle reflects a known advantage of the BD Rhapsody system in capturing an exceptionally high number of mRNA molecules per cell, leading to unprecedented insight into neutrophil heterogeneity and function.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11653533	Relevant papers were retrieved using keywords such as “Ficus auriculata,” “Ficus benghalensis,” “Ficus benjamina,” “Ficus carica,” “Ficus deltoidea,” “Ficus exasperata,” “Ficus microcarpa,” “Ficus racemosa,” “Ficus religiosa,” “Ficus sycomorus,” “biological properties,” “isolated compounds”, “phytochemicals”, “ethnopha...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11543885	The following day, co-transfect the cells with a 1:9 ratio (wt/wt) of pcDNA 5/FRT construct: pOG44 plasmid using Lipofectamine 3000 according to manufacturer’s instructions (https://www.thermofisher.com/order/catalog/product/L3000001).Note: Include a well of untransfected cells as a negative control and a well without ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10589262	The leukemia cell lines K562 and Kasumi-1 were cultured in RPMI1640 medium supplemented with 10% FBS.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "leukemia", "cell", "lines", ...
PMC9964635	The compound (2) was obtained as a pale yellow, oily liquid.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "compound", "(", "2", ")", "was", "obtained", "as", ...
PMC8753818	Following this cleavage, truncated Rb joins cyclin D3 and reduces E2F1 transcriptional activity .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Following", "this", "cleavage", ",", "truncated", "Rb", "joins", ...
PMC9388315	Treated cells were lysed by freeze-thawing and then used PBS buffer supplemented with antiprotease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treated", "cells", "were", "lysed", "by", "freeze-thawing", "and", ...
PMC9143157	In the implanted uterine sarcoma mice model, we clearly found that P-THP almost completely suppressed the tumor growth, in which the effect was much superior to the free THP, whereas no remarkable body weight loss was observed (Figure 3A, B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11632064	As expected, a detailed proliferation analysis of MeWo cells shows that BI-D1870 leads to rapid and sustained proliferation arrest (Fig 2A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "token...
PMC11594074	Conrad Waddington first established the term epigenetics to describe the mechanisms altering gene expression without changing the DNA sequence .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Conrad", "Waddington", "first", "...
PMC11467964	The distribution of patients in the two BMRG clustering, two gene clustering, and two risk groups was shown in Figure 5A.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11218145	Following this concept, in a previous work, we carried out an in vitro screening on immortalized and patient-derived primary MPM cell lines of 1170 FDA-approved drugs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11487720	We determined that the cell morphological changes during BCD and POD are unique, unlike in apoptosis or necrosis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "determined", "that", "the",...
PMC11637276	Box and whisker plots represent Min to Max, + represents the mean; N = 2 independent experiments. ***	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Box", "and",...
PMC8010066	DeLeon et al. (2014) used the term 'mutual benefit' for P. aeruginosa and S. aureus in cell culture conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DeLeon"...
PMC7136814	Similar response pattern was observed with A-204 ().	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similar", "response", "pattern", "was", "observed", "with", "A-204", "(", ")", "." ] } ]
PMC11768927	By simultaneously stimulating immunogenic cell death and mitigating immune checkpoint-mediated suppression, this strategy achieves robust tumor clearance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "By", "simultaneously", "stimulating", "immun...
PMC9429973	Median DoR was 25.7 mo (17.6, 31.5) for C+R vs 17.3 mo (12.6, 25.3) for P+R; for pts with complete responses, median DoR was 42.3 mo (29.2, not estimable) vs 24.7 mo (10.2, 29.7) (HR 0.46 [0.24, 0.87]).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11549612	Notably, the modulation of BOLA1, BOLA2, and BOLA3 expression introduces intriguing avenues for exploring its efficacy in cancer therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",...
PMC10813895	The expression of ELF5, predominantly isoform 2, is higher in basal-like BC and lower in luminal A/B and HER2+ BCs as compared to normal breast tissue (Figure 1B) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11473843	All analyses were run in R version 4.2.1 https://www.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "analyses", "were", "run", "in", "R", "version", "4.2.1", "https://www", "." ] } ]
PMC7039683	On average tiles overlapping biochemically-predicted periderm enhancers (i.e., zGPAEs) have higher scores than those that do not, but plots of these two distributions overlap, indicating that a high score is not a guarantee that an element is a periderm enhancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Both bleeding and cardiac events occurred at slightly lower rates on pacritinib compared to BAT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "bleeding", "and", "cardiac", "events", "occurred", ...
PMC10858941	Hypoxia-induced signalling emanates from the activation of the hypoxia-inducible factor 1α (HIF-1α).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hypoxia-induced", "signalling", "emanates", "from", "the", "activation", ...
PMC9503669	An isothiazolopyridinone analog from this series (SRI-37264; Figure 1) restored MHC-I expression to the surface of HIV-infected primary cells and disrupted a recombinant protein complex of Nef, the C-terminal tail of MHC-I and the μ1 subunit of the AP-1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7192625	The ChAs values of H3K27me3 were comparable but lower than those obtained for PCHi-C neutrophil networks (median = 0.23 compared to 0.3 in neutrophils).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	IFNg SFUs and RSV were significantly higher after 3 vs 2 doses at 242 and 9184 vs 72 and 5031 (p=0.0004/<0.0001, Fig. 1b,c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2777936	The chromatin of pluripotent cells is viewed as distinct from that of differentiated cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "chromatin", "of", "pluripotent", "cells", "is", "viewed", ...
PMC11802929	Libraries were multiplexed and loaded onto an Illumina flow cell for sequencing at 30x or higher coverage on a NovaSeq 6000 instrument.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Libraries", ...
PMC11747949	Treatment with vehicle or RS504393 (#2517, Tocris) 0.5 µM concentration was added and cells were incubated in 21% and 1% O2 After 24 h, healthy donor blood was collected in compliance with the bioethics protocol approved by the Vilnius Regional Committee of Biomedical Research (2020 03 31 Nr.2020/3˗1209˗694).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10936243	Also, our neutering cost is very low, so we only provide what is necessary” [D073].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Also", ",", "our", "ne...
PMC9444294	This is concordant with published literature across 8 studies, which have recorded a total of 303 positive IHC results from 326 (93%) synovial sarcoma samples, with sensitivity ranging from 86 to 100% in their respective studies.14,20–26 Only one study attributed negative samples to a rare alternative fusion splice sit...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5363531	Afterwards, we assessed whether pretreatment with dasatinib enhanced also the apoptotic event induced by PEM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Afterwards", ",", "we", "assessed", "whether", "pretre...
PMC11720107	Our results showed that the Harnaś garlic extract significantly increased ROS levels in BJ cells at concentrations of 0.250, 0.500, and 1.000 mg/mL, with increases of 29.8%, 184.8%, and 243.6%, respectively, compared with the control (Figure 1A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11638255	TETA treatment did not impact any analyte concentrations associated with hepatic, renal, or overall systemic disorders compared to the control (Supp.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9351137	=P<0.05, <=P<0.005, =P<0.0005Table 4Treatment with ZM447439 (ZM) and Barasertib (BS) inhibitorsDMSO (ZM)ZM447439DMSO (BS)BarasertibAurora B0.00 ± 0.000.00 ± 0.002.81 ± 1.1410.00 ± 0.00MKLP12.34 ± 3.2132.68 ± 0.87*7.50 ± 4.9521.00 ± 4.24BAF53a5.67 ± 2.0816.00 ± 5.006.50 ± 0.7124.50 ± 4.95*Tip602.58 ± 1.3...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10728535	The activation of this pathway is associated with aggressive phenotype, poor prognosis, and drug resistance in OC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "activation", "of", "this",...
PMC11674146	D, E) Phosphorylation level of PI3K/AKT/CREB in lymphoma cells quantified via immunoblotting assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", ",", "E", ")", "Phosphorylation", "level", "of", ...
PMC11467964	After that, patients were categorized into high‐ and low‐risk groups based on median risk score of training cohort, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "that", "...
PMC9429973	Although the role of nuclear IRAK4 in leukemia cells remains to be investigated, our preliminary findings revealed new perspectives into emavusertib treatment stratification and demonstrate the possibility of discovering novel biomarkers through IHC analysis of clinical samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11766332	The present study provided valuable insights into the potential link between ASD epigenetics, particularly miRNA deregulation, and glycosylation molecular mechanisms, a relationship that remains largely unexplored.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11306331	We tested three repeats of the disordered RGG domain from LAF-1 which has been shown to be solubilized by MBP fusion; the full-length RNA binding protein Oskar (Supplementary Movie 4), which is required to form germ granules during Drosophila development; mRNA decapping protein 1 A (DCP1A), which participates in mRNA d...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: We evaluated the in-vitro apoptotic effect of naturally occurring organic substances Piperine and Ascorbic acid in comparison to commonly used chemotherapeutic drug Fludarabine on an AML cell line (HL-60 leukaemia cells).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10671321	In conclusion, our results suggest that the CMS caused by the pathogenic variant of the D-CTD is probably not due to the complete lack of AChE in the synaptic cleft but could be at least partially due to the impaired interaction of ColQ with LRP4 through its D-CTD and putative defects in downstream pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11777207	We observed comparable transduction efficiencies, as assayed by PD-L1 expression in Pdl1 BMDCs, between full-length WT PD-L1, PD-L1 Y56A, PD-L1 D122S, and tailless PD-L1 by anti–PD-L1 staining using gMFI (Fig. 5, C and D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11678841	Current models of VVC etiopathogenesis suggest that the presence of a significant load of filamentous forms and the production of candidalysin significantly contribute to the onset of the non-protective inflammatory response characteristic of this infection .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11477621	A multi-label microplate analysis system (PerkinElmer Envision, Waltham, MA, USA) detected the fluorescence values at 620 nm and 665 nm, and calculated the HTRF signal ratio (665 nm/620 nm) of each well.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787355	tumor size with MRI and assessment of radiographic response upon ACT treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "tumor", "size", "with", "MRI", "and", "assessment", "of", "radiographic", "respo...
PMC9429973	Image: Summary/Conclusion: Preliminary analysis of data from the 7 mg IV and 14 mg SC DISC-0974 cohorts shows an acceptable safety and tolerability profile, as well as evidence of target engagement and iron mobilization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10440586	These patients received nivolumab administration followed by tumor resection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "patients", "received", "nivolumab", "administration", "followed", "by", "tumor", "resection", "." ...
PMC11730320	G Monocytes were within low to normal ranges.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "G", "Monocytes", "were", "within", "low", "to", "normal", "ranges", "." ] } ]
PMC9960565	On the other hand, in the case of MCF-7 and CACO-2 cell lines, all SI values were inferior to 2 (also for cisplatin), only evidencing general toxicity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11679892	The application procedure was as follows: First, the standard concentration provided with the kit was prepared by serial dilution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "application", ...
PMC11411004	After 48 h of exposure, changes in the protein expression levels of the LSD1 protein and LSD1 substrate H3K4me2, and the HDAC substrates Ac-H3K9 Ac-H3K27, and total histone H3 were detected using Western blotting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11129910	The results obtained from our study so far reveal that HMEC 5.6 RAB25- Clone#5 and RAO-4 cells can give rise to the claudin-low subtype of triple-negative breast cancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "B-CellLine", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC9429973	The 3-year survival probability for OS, EFS, and DFS for low risk APML was 90% (95% C.I, 84.1-96.4), 80.1% (95% C.I, 72-89.1), 84.5% (95% C.I, 76.9-92.7) respectively whereas for high risk APML was 84.7% (95% C.I, 75.3-95.2), 68.6% (95% C.I, 56.9-82.9), 76.1% (95% C.I-65-89) respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11769516	is a small polar molecule possessing a cyclobutanedione structure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "is", "a", "small", "polar", "molecule", "possessing", "a", "cyclobutanedione", "structure", "." ] } ]
PMC10198699	For an unjustified enrichment action to be successful, the present-day Henrietta Lacks would need to prove, inter alia, that she was impoverished by the operation of specificatio.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11519077	In addition, all groups were compared to the control for the p53 gene, which is an important gene connected to apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC9429973	Here we report the results of the first 9 patients in the run-in phase 1 part of the study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", "we", "report", "the", ...
PMC11743414	C Western Blot grayscale value quantification. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", "Western", "Blot", "grayscale", "value", "quantification", ".", "*" ] } ]
PMC10840195	The CCK-8 assay results showed that the IC50 of the parent strain (A498) (Fig. 1A) to sunitinib was 7.294 µM, while the IC50 of the constructed SR-A498 cells (Fig. 1B) to sunitinib was 18.114 µM. The drug resistance index (RI) was 2.5, and the BrdU incorporation assay showed that the cell viability of SR-A498 cells was...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11351758	In conclusion, we postulate that mitoQ has the potential to rescue the high glucose toxicity in both the NARP and 143B cells observed above by scavenging mROS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "...
PMC11377827	Cells were sorted using an Influx cell sorter and kept on ice through this process to maintain the stability of the reporter.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "wer...
PMC9792775	Drug loading assays were performed using an HPLC obtained from Waters Corporation (Waltham, United States).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Drug", "loading", "assays", "were", "p...
PMC11725127	Kaplan–Meier curves indicating overall survival (OS) of MM patients with low or high levels of USP2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Kaplan", "–", "Meier", ...
PMC11730311	This CLR:RAMP1 receptor complex is commonly referred to as the CGRP receptor (CGRP-R).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "CLR", ":", "RAMP1", "receptor", "co...
PMC11033180	Enteric neurons were transferred to a recording chamber and perfused with an external solution containing (in mM): 5 mM Glucose, 2 mM CaCl2, 135 mM NaCl, 5.4 mM KCl, 1 mM MgCl2, 0.33 mM NaH2PO4 and 5 mM HEPES (pH set to 7.4 and osmolarity set to 300 mosmol) at room temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11218145	The different parameters were calculated as follow.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "different", "parameters", "were", "calculated", "as", "follow", "." ] } ]
PMC9429973	The primary endpoint is MMR rate (BCR::ABL1 ≤0.1%) at wk 48 in pts not in MMR at baseline.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "primary", ...
PMC8041314	Inclusion of these discriminated partial structures would inevitably have led to the prediction of more false positive hits and a decreased biological hit rate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC5673060	The discovery that the phosphorylation of multiple transcription factors is upregulated in SMARCB1-deficient parental A204 rhabdoid tumour cells is consistent with the role of SMARCB1 in organising nucleosome structures surrounding transcriptional start sites in a genome-wide manner .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11277157	Only genes with an absolute log fold change of ≥0.5 were labeled up- or downregulated, all the rest were considered unchanged.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Only", "gene...
PMC8358176	The expression of two genes (TNF and TNFRSF10A) changed significantly.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expression", "of", "two", "genes", "(", "TNF", "and", "TNFRSF10A", ...
PMC9065483	Lysates were fractionated for nuclear and cytoplasmic fractions and probed for phosphorylated STAT1, total STAT1, phosphorylated STAT2, total STAT2, lamin B1, and alpha-tubulin by western blot. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10798140	Cancerous diseases are, without doubt, one of the world's most serious health issues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cancerous", "diseases", "are", ",", "without", "doubt"...
PMC11496728	After transfecting CHO-S cells with IL-3-containing plasmids, cell supernatants were collected from a culture suspended for 7 days, and transient and stable expression of IL-3 was detected using the human IL-3 ELISA kit (Neobioscience, Shenzhen, China).	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11502327	The three major advantages of metal and oxide nanoparticles in medicine are their strong stability, large surface area and good size effect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...

PMC6102174

In addition to anti-HBV efficiency, TCMs can reduce the ALT and AST levels by improving the hepatic function of patients, and relieve HBV-associated clinical symptoms, e.g. anorexia, hypodynamia, nausea and vomiting, to improve the life quality of patients.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11741906

Fig. 5 Effect of differentially expressed miRNAs related to cisplatin resistance on Pathways in cancer.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "5", "Effect", "of", "differentially", "expressed", ...

PMC8097906

Initial anti-tumor screenings of all substances analyzed in this study, identified the plant extract of Vincetoxicum arnottianum (VSM) as the most promising candidate, harboring the highest anti-metastatic potential.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10932641

After the cryopreservation tube of Renal cancer cell line 786-0 was thawed from the liquid nitrogen tank, the cells were cultured in RPMI1640 complete medium containing 10% FBS and 1% penicillin-streptomycin mixed solution and then placed in a 37 ℃, 5% CO2, saturated humidity incubator.

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PMC11621565

After 72 h, the medium was replaced with differentiation medium, supplemented with 80 nM of phorbole-myristate-acetate (PMA) for another 72 h, after which the medium was changed, and the cells were treated for 48 h with microbial-derived molecules according to the experimental design.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11753949

Regions of interest were sectioned (50–60nm) and imaged using a Talos L120C TEM microscope at 80kV. EM reagents are from EMS, Hatfield, PA unless noted otherwise.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8609870

First, based on the threshold values (r < 0 and p value < 0.05), we evaluated the relationship between downregulated lncRNAs and upregulated miRNAs shown in Fig. 4a, and the relationship between upregulated lncRNAs and downregulated miRNAs was displayed in Additional file 2: Figure S2.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11092418

We found that treatments with the targeted agents such as stattic, neratinib, trametinib were more effective than other targeted agents by inhibiting the migration of A172 cells (Fig. 4).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11412721

Details on the four p53 mutations identified in (D).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Details", "on", "the", "four", "p53", "mutations", "identified", "in", "(", "D", ...

PMC11731614

2Isolated extracellular vesicles from SEC fraction 2/3 are functionally retrogradely trafficked by DRG neurons in vitro.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "2Isolated", "extracellular", "vesicles", "from", "SEC", ...

PMC9532503

It can be seen from the figure that the association (ka), dissociation (kd), and binding affinity (KD) of test antibody (P2-CRD-1508) was high in comparison to control antibody (RS-03-25)Table 5SPR kinetic values obtained for FcγRIIIa V158 (A and B) and F158 (C and D) receptors for the test anti-CD20 antibody and contr...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11785489

We approximated each TCR’s affinity to the MART-1 tetramer with EC5, the tetramer concentration at which 5% of Jurkat cells stain positively for tetramer.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", ...

PMC11612794

Phosphorylation of the Dsn1 basic motif by Aurora B precludes the mask by inhibiting the basic motif binding to the Nsl1 acidic surface.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Phospho...

PMC11194678

The above observation suggests a potential connection between enlarged cytoplasmic STAU1 puncta and upregulation of STAU1 and mTOR levels.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "above", "observation", "su...

PMC11740207

Activation of these pathways promotes the early stages of mesodermal development.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Activation", "of", "these", "pathways", "promotes", "the", "early", "stages", "of", "...

PMC11419566

PA is combined with anticancer drugs and radiotherapy to increase the sensitivity of cancer cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PA", "is", "combined", "with", "anticancer", "drugs", "and"...

PMC11228511

In earlier studies (13), we found that overexpression of an inner NM protein, LAP2β, eliminated NM ruptures in LmnaLmnb1Lmnb2 fibroblasts.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11757230

Further inquiries can be directed to the corresponding author.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "inquiries", "can", "be", "directed", "to", "the", "corresponding", "author", "." ] } ]

PMC9429973

CRS in all pts was manageable and resolved after treatment with Ruxolitinib, SOC and supportive care.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CRS", "in", "all", "pts", "was", "manageabl...

PMC9429973

Methods: Multicenter, retrospective, observational report of myeloproliferative neoplasms in 13 mexican medical centers.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "Multicenter", ",", "retrospective", ",...

PMC11576293

In all cases, these compounds have lower efficacy than compound 22, suggesting that the 4-OMe-benzyl group at position two is critical for the antiproliferative action.

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PMC9429973

The Lugano response criteria were used to assess disease response.

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PMC11638255

This technical hurdle reflects a known advantage of the BD Rhapsody system in capturing an exceptionally high number of mRNA molecules per cell, leading to unprecedented insight into neutrophil heterogeneity and function.

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PMC11653533

Relevant papers were retrieved using keywords such as “Ficus auriculata,” “Ficus benghalensis,” “Ficus benjamina,” “Ficus carica,” “Ficus deltoidea,” “Ficus exasperata,” “Ficus microcarpa,” “Ficus racemosa,” “Ficus religiosa,” “Ficus sycomorus,” “biological properties,” “isolated compounds”, “phytochemicals”, “ethnopha...

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PMC11543885

The following day, co-transfect the cells with a 1:9 ratio (wt/wt) of pcDNA 5/FRT construct: pOG44 plasmid using Lipofectamine 3000 according to manufacturer’s instructions (https://www.thermofisher.com/order/catalog/product/L3000001).Note: Include a well of untransfected cells as a negative control and a well without ...

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PMC10589262

The leukemia cell lines K562 and Kasumi-1 were cultured in RPMI1640 medium supplemented with 10% FBS.

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PMC9964635

The compound (2) was obtained as a pale yellow, oily liquid.

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PMC8753818

Following this cleavage, truncated Rb joins cyclin D3 and reduces E2F1 transcriptional activity .

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PMC9388315

Treated cells were lysed by freeze-thawing and then used PBS buffer supplemented with antiprotease.

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PMC9143157

In the implanted uterine sarcoma mice model, we clearly found that P-THP almost completely suppressed the tumor growth, in which the effect was much superior to the free THP, whereas no remarkable body weight loss was observed (Figure 3A, B).

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PMC11632064

As expected, a detailed proliferation analysis of MeWo cells shows that BI-D1870 leads to rapid and sustained proliferation arrest (Fig 2A).

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PMC11594074

Conrad Waddington first established the term epigenetics to describe the mechanisms altering gene expression without changing the DNA sequence .

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PMC11467964

The distribution of patients in the two BMRG clustering, two gene clustering, and two risk groups was shown in Figure 5A.

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PMC11218145

Following this concept, in a previous work, we carried out an in vitro screening on immortalized and patient-derived primary MPM cell lines of 1170 FDA-approved drugs.

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PMC11487720

We determined that the cell morphological changes during BCD and POD are unique, unlike in apoptosis or necrosis .

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PMC11637276

Box and whisker plots represent Min to Max, + represents the mean; N = 2 independent experiments. ***

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PMC8010066

DeLeon et al. (2014) used the term 'mutual benefit' for P. aeruginosa and S. aureus in cell culture conditions.

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PMC7136814

Similar response pattern was observed with A-204 ().

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PMC11768927

By simultaneously stimulating immunogenic cell death and mitigating immune checkpoint-mediated suppression, this strategy achieves robust tumor clearance.

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PMC9429973

Median DoR was 25.7 mo (17.6, 31.5) for C+R vs 17.3 mo (12.6, 25.3) for P+R; for pts with complete responses, median DoR was 42.3 mo (29.2, not estimable) vs 24.7 mo (10.2, 29.7) (HR 0.46 [0.24, 0.87]).

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PMC11549612

Notably, the modulation of BOLA1, BOLA2, and BOLA3 expression introduces intriguing avenues for exploring its efficacy in cancer therapy.

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PMC10813895

The expression of ELF5, predominantly isoform 2, is higher in basal-like BC and lower in luminal A/B and HER2+ BCs as compared to normal breast tissue (Figure 1B) .

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PMC11473843

All analyses were run in R version 4.2.1 https://www.

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PMC7039683

On average tiles overlapping biochemically-predicted periderm enhancers (i.e., zGPAEs) have higher scores than those that do not, but plots of these two distributions overlap, indicating that a high score is not a guarantee that an element is a periderm enhancer.

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PMC9429973

Both bleeding and cardiac events occurred at slightly lower rates on pacritinib compared to BAT.

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PMC10858941

Hypoxia-induced signalling emanates from the activation of the hypoxia-inducible factor 1α (HIF-1α).

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PMC9503669

An isothiazolopyridinone analog from this series (SRI-37264; Figure 1) restored MHC-I expression to the surface of HIV-infected primary cells and disrupted a recombinant protein complex of Nef, the C-terminal tail of MHC-I and the μ1 subunit of the AP-1.

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PMC7192625

The ChAs values of H3K27me3 were comparable but lower than those obtained for PCHi-C neutrophil networks (median = 0.23 compared to 0.3 in neutrophils).

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PMC9429973

IFNg SFUs and RSV were significantly higher after 3 vs 2 doses at 242 and 9184 vs 72 and 5031 (p=0.0004/<0.0001, Fig. 1b,c).

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PMC2777936

The chromatin of pluripotent cells is viewed as distinct from that of differentiated cells.

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PMC11802929

Libraries were multiplexed and loaded onto an Illumina flow cell for sequencing at 30x or higher coverage on a NovaSeq 6000 instrument.

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PMC11747949

Treatment with vehicle or RS504393 (#2517, Tocris) 0.5 µM concentration was added and cells were incubated in 21% and 1% O2 After 24 h, healthy donor blood was collected in compliance with the bioethics protocol approved by the Vilnius Regional Committee of Biomedical Research (2020 03 31 Nr.2020/3˗1209˗694).

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PMC10936243

Also, our neutering cost is very low, so we only provide what is necessary” [D073].

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PMC9444294

This is concordant with published literature across 8 studies, which have recorded a total of 303 positive IHC results from 326 (93%) synovial sarcoma samples, with sensitivity ranging from 86 to 100% in their respective studies.14,20–26 Only one study attributed negative samples to a rare alternative fusion splice sit...

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PMC5363531

Afterwards, we assessed whether pretreatment with dasatinib enhanced also the apoptotic event induced by PEM.

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PMC11720107

Our results showed that the Harnaś garlic extract significantly increased ROS levels in BJ cells at concentrations of 0.250, 0.500, and 1.000 mg/mL, with increases of 29.8%, 184.8%, and 243.6%, respectively, compared with the control (Figure 1A).

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PMC11638255

TETA treatment did not impact any analyte concentrations associated with hepatic, renal, or overall systemic disorders compared to the control (Supp.

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PMC9351137

=P<0.05, **<=P<0.005, ***=P<0.0005Table 4Treatment with ZM447439 (ZM) and Barasertib (BS) inhibitorsDMSO (ZM)ZM447439DMSO (BS)BarasertibAurora B0.00 ± 0.000.00 ± 0.002.81 ± 1.1410.00 ± 0.00*MKLP12.34 ± 3.2132.68 ± 0.87***7.50 ± 4.9521.00 ± 4.24***BAF53a5.67 ± 2.0816.00 ± 5.00***6.50 ± 0.7124.50 ± 4.95***Tip602.58 ± 1.3...

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PMC10728535

The activation of this pathway is associated with aggressive phenotype, poor prognosis, and drug resistance in OC.

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PMC11674146

D, E) Phosphorylation level of PI3K/AKT/CREB in lymphoma cells quantified via immunoblotting assay.

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PMC11467964

After that, patients were categorized into high‐ and low‐risk groups based on median risk score of training cohort, respectively.

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PMC9429973

Although the role of nuclear IRAK4 in leukemia cells remains to be investigated, our preliminary findings revealed new perspectives into emavusertib treatment stratification and demonstrate the possibility of discovering novel biomarkers through IHC analysis of clinical samples.

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PMC11766332

The present study provided valuable insights into the potential link between ASD epigenetics, particularly miRNA deregulation, and glycosylation molecular mechanisms, a relationship that remains largely unexplored.

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PMC11306331

We tested three repeats of the disordered RGG domain from LAF-1 which has been shown to be solubilized by MBP fusion; the full-length RNA binding protein Oskar (Supplementary Movie 4), which is required to form germ granules during Drosophila development; mRNA decapping protein 1 A (DCP1A), which participates in mRNA d...

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PMC9429973

Aims: We evaluated the in-vitro apoptotic effect of naturally occurring organic substances Piperine and Ascorbic acid in comparison to commonly used chemotherapeutic drug Fludarabine on an AML cell line (HL-60 leukaemia cells).

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PMC10671321

In conclusion, our results suggest that the CMS caused by the pathogenic variant of the D-CTD is probably not due to the complete lack of AChE in the synaptic cleft but could be at least partially due to the impaired interaction of ColQ with LRP4 through its D-CTD and putative defects in downstream pathways.

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PMC11777207

We observed comparable transduction efficiencies, as assayed by PD-L1 expression in Pdl1 BMDCs, between full-length WT PD-L1, PD-L1 Y56A, PD-L1 D122S, and tailless PD-L1 by anti–PD-L1 staining using gMFI (Fig. 5, C and D).

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PMC11678841

Current models of VVC etiopathogenesis suggest that the presence of a significant load of filamentous forms and the production of candidalysin significantly contribute to the onset of the non-protective inflammatory response characteristic of this infection .

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PMC11477621

A multi-label microplate analysis system (PerkinElmer Envision, Waltham, MA, USA) detected the fluorescence values at 620 nm and 665 nm, and calculated the HTRF signal ratio (665 nm/620 nm) of each well.

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PMC11787355

tumor size with MRI and assessment of radiographic response upon ACT treatment.

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PMC9429973

Image: Summary/Conclusion: Preliminary analysis of data from the 7 mg IV and 14 mg SC DISC-0974 cohorts shows an acceptable safety and tolerability profile, as well as evidence of target engagement and iron mobilization.

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PMC10440586

These patients received nivolumab administration followed by tumor resection.

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PMC11730320

G Monocytes were within low to normal ranges.

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PMC9960565

On the other hand, in the case of MCF-7 and CACO-2 cell lines, all SI values were inferior to 2 (also for cisplatin), only evidencing general toxicity.

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PMC11679892

The application procedure was as follows: First, the standard concentration provided with the kit was prepared by serial dilution.

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PMC11411004

After 48 h of exposure, changes in the protein expression levels of the LSD1 protein and LSD1 substrate H3K4me2, and the HDAC substrates Ac-H3K9 Ac-H3K27, and total histone H3 were detected using Western blotting.

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PMC11129910

The results obtained from our study so far reveal that HMEC 5.6 RAB25- Clone#5 and RAO-4 cells can give rise to the claudin-low subtype of triple-negative breast cancers.

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PMC9429973

The 3-year survival probability for OS, EFS, and DFS for low risk APML was 90% (95% C.I, 84.1-96.4), 80.1% (95% C.I, 72-89.1), 84.5% (95% C.I, 76.9-92.7) respectively whereas for high risk APML was 84.7% (95% C.I, 75.3-95.2), 68.6% (95% C.I, 56.9-82.9), 76.1% (95% C.I-65-89) respectively.

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PMC11769516

is a small polar molecule possessing a cyclobutanedione structure.

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PMC10198699

For an unjustified enrichment action to be successful, the present-day Henrietta Lacks would need to prove, inter alia, that she was impoverished by the operation of specificatio.

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PMC11519077

In addition, all groups were compared to the control for the p53 gene, which is an important gene connected to apoptosis.

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PMC9429973

Here we report the results of the first 9 patients in the run-in phase 1 part of the study.

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PMC11743414

C Western Blot grayscale value quantification. *

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PMC10840195

The CCK-8 assay results showed that the IC50 of the parent strain (A498) (Fig. 1A) to sunitinib was 7.294 µM, while the IC50 of the constructed SR-A498 cells (Fig. 1B) to sunitinib was 18.114 µM. The drug resistance index (RI) was 2.5, and the BrdU incorporation assay showed that the cell viability of SR-A498 cells was...

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PMC11351758

In conclusion, we postulate that mitoQ has the potential to rescue the high glucose toxicity in both the NARP and 143B cells observed above by scavenging mROS.

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PMC11377827

Cells were sorted using an Influx cell sorter and kept on ice through this process to maintain the stability of the reporter.

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PMC9792775

Drug loading assays were performed using an HPLC obtained from Waters Corporation (Waltham, United States).

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PMC11725127

Kaplan–Meier curves indicating overall survival (OS) of MM patients with low or high levels of USP2.

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PMC11730311

This CLR:RAMP1 receptor complex is commonly referred to as the CGRP receptor (CGRP-R).

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PMC11033180

Enteric neurons were transferred to a recording chamber and perfused with an external solution containing (in mM): 5 mM Glucose, 2 mM CaCl2, 135 mM NaCl, 5.4 mM KCl, 1 mM MgCl2, 0.33 mM NaH2PO4 and 5 mM HEPES (pH set to 7.4 and osmolarity set to 300 mosmol) at room temperature.

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PMC11218145

The different parameters were calculated as follow.

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PMC9429973

The primary endpoint is MMR rate (BCR::ABL1 ≤0.1%) at wk 48 in pts not in MMR at baseline.

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PMC8041314

Inclusion of these discriminated partial structures would inevitably have led to the prediction of more false positive hits and a decreased biological hit rate.

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PMC5673060

The discovery that the phosphorylation of multiple transcription factors is upregulated in SMARCB1-deficient parental A204 rhabdoid tumour cells is consistent with the role of SMARCB1 in organising nucleosome structures surrounding transcriptional start sites in a genome-wide manner .

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PMC11277157

Only genes with an absolute log fold change of ≥0.5 were labeled up- or downregulated, all the rest were considered unchanged.

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PMC8358176

The expression of two genes (TNF and TNFRSF10A) changed significantly.

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PMC9065483

Lysates were fractionated for nuclear and cytoplasmic fractions and probed for phosphorylated STAT1, total STAT1, phosphorylated STAT2, total STAT2, lamin B1, and alpha-tubulin by western blot. (

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PMC10798140

Cancerous diseases are, without doubt, one of the world's most serious health issues.

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PMC11496728

After transfecting CHO-S cells with IL-3-containing plasmids, cell supernatants were collected from a culture suspended for 7 days, and transient and stable expression of IL-3 was detected using the human IL-3 ELISA kit (Neobioscience, Shenzhen, China).

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PMC11502327

The three major advantages of metal and oxide nanoparticles in medicine are their strong stability, large surface area and good size effect.

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