OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11190538	Ltd., Cambridge, UK).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ltd.", ",", "Cambridge", ",", "UK", ")", "." ] } ]
PMC11476004	The comet assay is the cytogenetic test most often used in people and animals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "comet", "assay", "is", "the", "cytogenetic", "test", "mos...
PMC6889484	In future studies, it may be possible to achieve high levels of lentiviral transduction as well as enable pharmacologic selection of the transduced cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11337594	Despite the initial efficacy of targeted therapies, the emergence of resistance appears to be a common issue associated with these drugs [14–16].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9424261	Taken together, we showed that CA can increase the sensitivity of liver cancer cells to ferroptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Taken", "together", ",", "we", "showed", "t...
PMC11534035	These results further highlight the significance of PAI1 as a pivotal protein involved in the functional aspects of malignant cells in VC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "res...
PMC11680562	Xanthan gum consists of extended carbohydrate chains that create a network capable of efficiently trapping water molecules, hence greatly increasing the viscosity of solutions and formulations .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11549612	Methylation analysis via the GSCA database.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methylation", "analysis", "via", "the", "GSCA", "database", "." ] } ]
PMC9429973	Eight underwent Treg/Tcon HSCT (3 from HLA-matched, 5 from HLA-haploidentical donor), while 2 unmanipulated haploidentical HSCT followed by post-transplant cyclophosphamide (PT-Cy).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11802929	Gene expression UMAP (GEX-UMAP) was generated based on scRNAseq.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gene", "expression", "UMAP", "(", "GEX-UMAP", ")", "was", "generated", "based", "on",...
PMC8270637	Fluorescence-conjugated mAbs to CD3 and CD8 were purchased from BD Biosciences (San Jose, CA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fluorescence-conjugated", "mAbs", "to",...
PMC9429973	Moreover, stroke was more common in MPNs with concomitant HTN (HR=4.24) and HTN was a predictor of ischemic stroke recurrence in MPNs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10891340	RNA was isolated from infected and uninfected DEFs at different time using TRIzol reagent (Invitrogen, Carlsbad, CA), and the purity and concentration of RNA was determined using a NanoDrop ND-1000 spectrophotometer at a ratio of A260/A280, with ratios between 1.8 and 2.0.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7057940	Conventional PCR was performed to detect the presence of genes EWS, FLI1 and reciprocal fusion gene FLI1-EWS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Conventional", "PCR", "was", "performed", ...
PMC11591038	Consistently in the brains of adult (50–60 weeks of age) Tg2576 AD mice, immunofluorescence staining of brain microvessels revealed a significantly higher level of HIF-1α along with the heightened expression of pro-angiogenic factors and reduced anti-apoptotic Bcl-xL .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10523483	Mice harboring Kras-driven lung cancer with wild-type H1.2 (Kras; H1c, abbreviated as K) and with H1.2 knockout (Kras; H1c, abbreviated as KH) were used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11033180	Therefore, we asked whether Sema5A could induce CaMKII or ERK activation by examining their level of phosphorylation at Tyr286 and Thr202/Tyr204, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11655536	B Comparison the expression levels of NHE1 in HD, SMM, MGUS, ND and RR in MM datasets (GSE6477).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", ...
PMC3164356	Pathways are adapted loosely from ref.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pathways", "are", "adapted", "loosely", "from", "ref", "." ] } ]
PMC9429973	All these elements are potential targets for specific interventions by the social system to improve HRQoL in NHL patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "these", "elements", "are",...
PMC8010066	Thus, there was a significant correlation between SA-1 and the viability of P. aeruginosa strains (P-value 0.0001, P-value 0.0002, and P-value 0.0001 for PA-2, PA-3, and PA-4, respectively).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11745823	In T98G and A‐172 cell lines, sh‐RNAs targeting c‐Myc were employed to further investigate its role in RIT1‐mediated glioma cell proliferation.	[ { "tags": [ "O", "B-CellLine", "I-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], ...
PMC11703992	B The cell viability of different groups of Jurkat cells, including DDIT4-KD/OE/Blank groups and the PMA induced/DDIT4-OE-PMA induced Jurkat cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "B", "...
PMC11698348	PMEKs were cultures and transfected with Controls, pElf5-OE and/or siElf5 as described above.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PMEKs", "were", "cultures", "and", "transfected", "with", "Controls", ...
PMC9429973	Notably, although minor proportion of proliferating cells were enriched in the end of P4 pseudotime trajectories, clusters could not be split in P4 patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11752767	Therefore, TCR-T is considered another promising ACT modality for advanced melanoma, due to its highly immunogenetic next to the TIL therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefo...
PMC11509309	High-resolution mass spectra were obtained with a Q-TOF mass spectrometer (Synapt XS, Waters Corporation, Milford, NY, USA) at the UBO platform or on a Q-Exactive spectrometer (Thermo Fisher Scientific, Waltham, MA, USA) at the CRMPO platform, both using a direct electrospray infusion (ESI) of the purified compounds di...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9577200	To determine the turbidity of the bacteria, 200 μl of the diluted cell suspension of each bacterium (OD600 = 0.5) was mixed with 20 μl of various starting GO concentrations (100, 200, 300, 400, 500, 600, and 700 mg ml), various starting levels of CS (0.2, 0.4, 0.6, 0.8, 1, and 1.5%), and the previous different ratios o...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11098378	Although the absolute fold changes in arbovirus replication varied between our initial screen using pIB/V5-His and our confirmatory screen with pDGOpIE2, the overall trends in SopB rescue were similar (Fig 2B–2E versus Fig 3C–3F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11397654	This research indicates that the amphiphilic character of the aggregates improves the selectivity of OHC against cancer cells, with the anticancer activity against human duodenal adenocarcinoma especially worth further research.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11634027	The RMCE cassette was then replaced by site-specific recombination with either wild-type ds sequences, or with ds sequences in which one of the motifs A-F were deleted.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Approximately, 79% of Medicaid patients were admitted to the hospital via the emergency room visit.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Approximately", ",", "79", "%", "of", "Medi...
PMC9220170	It has been reported that the downregulation of two important enzymes of the ERAD system in SELENOT-KD results in the accumulation of misfolded proteins in the ER lumen, which appears to exacerbate ER stress in A-172 cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11713609	Scale bar, 1 cm. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ",", "1", "cm", ".", "(" ] } ]
PMC3019555	Live cell imaging of HeLa–GFP-Ago2 cells treated with 100 µM 2ME2, 1 µM TX, or 30 µM Noc for 1 h. (B) HeLa–GFP-Ago2 (green) cells treated with 25 µM 2ME2 or 50 nM TX overnight, fixed, and stained for GE-1 (red) and α-tubulin (white).	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11585254	The net BRET was calculated by subtracting the BRET ratio from cells transfected with only donor plasmid.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "net", "BRET", "was", "calculated", "...
PMC11680982	Effects of CDK4/6 inhibitor + endocrine therapy and triple combination treatment (neratinib, CDK4/6 inhibitor and endocrine therapy) on HER2 mRNA stability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11718817	In a previous paper, we could describe T-cell-intrinsic effects of NLRP3-mediated cytokine signaling .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "a", "previous", "paper", ",", "we", "could", "describe", ...
PMC9856122	An antiviral study included didehydro-cortistatin and highlighted ‘‘Block-and-lock’’ approach for the treatment of HIV.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "antiviral", "study", "included", "didehydro...
PMC11045125	As expected, Myc expression was dramatically decreased in this cell line after three days of doxycycline treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "expected", ",", "Myc", "expressi...
PMC10993311	EMILINs are extracellular matrix glycoproteins with regulatory functions in cell migration, differentiation, and proliferation (Zacchigna et al., 2006).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "EMILINs...
PMC11291490	Further information on research design is available in the Nature Research Reporting Summary linked to this article.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "information", "on", "research", "desig...
PMC4270159	Treatment of a control cell line with the growth factor ligand alone.i.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "of", "a", "control", "cell", "line", "with", "the", "growth", ...
PMC5311252	This model is further supported by the fact that ectopic expression of oncomotif-miRNAs results in increased proliferation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "model", "is", "further", "supported", ...
PMC11144200	E The number of apoptosis cells detection by TUNEL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "E", "The", "number", "of", "apoptosis", "cells", "detection", "by", "TUNEL", "." ] } ]
PMC9429973	Methods: Consistent with studies of other R/R DLBCL treatments, identified through a literature review, parametric and mixture cure models were fit utilizing multiple distributions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	A total of 14 (87.5%) participants had at least one treatment emergent adverse event (TEAE).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "total", "of", "14...
PMC9429973	These data provide a historical reference for expected outcomes that may serve as a benchmark for the evaluation of novel drugs and combinations in the setting of INO/Blina failure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754432	Whereas, DHA was shown to reduce PPARδ and activate PPARγ, in addition to reducing TNFα secretion and lowering hyperproliferation in skin equivalents .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9341513	to the region and local chromatin states and DNA accessibility are altered.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "to", "the", "region", "and", "local", "chromatin", "states", "and", "DNA", ...
PMC11704834	EGFR-TKI resistance mechanisms include secondary EGFR mutations (for example, T790M), bypass signaling activations (for example, MET amplification) and phenotypic transformation [for example, epithelial-mesenchymal transition (EMT)] (2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Sequencing these options and identifying the optimal choice of treatment for individual patients can be challenging for practicing oncologists.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sequencing", "these", "options", ...
PMC11718274	The results of alkaline Comet assay, ROS generation, integrity of mitochondrial membrane potential, qRT-PCR and oxidative stress markers were expressed as mean ± SD and were statistically analyzed using the Statistical Package for the Social Sciences 20 (SPSS 20).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7081114	However, most HCC patients are diagnosed at advanced stages, and recurrence and metastasis remain major challenges in HCC treatment, leading to an extremely poor prognosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11337594	This was achieved through a dual mechanism involving promotion of cell death and inhibition of cell proliferation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "was", "achieved", "through", "a", "...
PMC10421378	Ch01 contains brightfield images recorded for individual events as they pass through the flow cell.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ch01", "contains", "brightfield", "images", "recorded", "for", ...
PMC9927933	Like UBE2C knockdown, CDH1 knockdown also inactivated mTORC1/2 signaling in all 3 cell lines tested without affecting the MAPK signaling in 2 cell lines (Figure 4B and Supplemental Figure 4B), suggesting that APC/C E3 couples with UBE2C E2 to control the abundance of DEPTOR, thus regulating mTORC1/2 signaling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8193046	As indicated above, ABCB1, ABCC1, and ABCG2 are the most investigated and understood ABC transporters, and hence, represent model targets for the generation of pan-ABC transporter inhibitors .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11098378	A. Six structural homologs of Ceg10, shown in the same orientation with the putative active site near the top of the figure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A.", ...
PMC11670407	The electron microscopy results revealed that OTULIN deficiency promoted cisplatin-induced death in osteosarcoma cells, which exhibited a morphology closer to that of apoptotic cells and aggravated mitochondrial damage, including mitochondrial swelling and membrane rupture (Fig. 5h).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11786600	This technique produces a fibrous membrane with high porosity and good pore interconnectivity, which creates a microenvironment conducive to cellular response and wound healing, inducing more M2 macrophages.13,14 Portable electrospinning filaments, a novel electrospinning filament variant, can rapidly produce films wit...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11247842	In this study, summary statistics of sequence-based GWAS for CM and SCS were combined with single- and multi-trait meta-analysis methods to identify sequence variants associated with CM, SCS, or both.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8345486	The effect of prolonged cultivation of cells in a medium with the addition of the compounds was evaluated after removing the medium enriched with the compounds, replacing it with the basal medium, and processing the culture for an additional three days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11805741	The control group, with no treatment, exhibited high reduction rates (71.67% at 24 h and 95.67% at 48 h), demonstrating robust cell migration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11577421	Cells were cultured in DMEM culture medium supplemented with 10% FBS and 1% penicillin/streptomycin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "cultured", "in", "DMEM", "culture", ...
PMC11721295	The average expression values of ligands and receptors in each cell population for both groups (KRAS and non–KRAS-driven) were calculated individually.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11718817	Addition of macrophages not only as a passive “ingredient” of the spheroid seed but as an active contributor toward intratumoral motility has, to our knowledge, not been shown before.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11267036	Each experiment was repeated thrice.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "experiment", "was", "repeated", "thrice", "." ] } ]
PMC9429973	Results: The study was launched on March 2015 and completed all participants’ planned visits as of Feb 2022 with a median follow-up duration of 27.5 months (range 2-51 months).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5874706	The 4-methoxy-5-isopropyl-5,6,7,8-tetrahydroindeno[1,2-b]indole-9,10-dione (THN7, Figure 1) was identified as a potent inhibitor of CK2 (IC50 = 71 nM, unpublished data) and then selected for new encapsulation in a set of amphiphilic cyclodextrins (CDs).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	At EOT, PET response was CR n=41 (63%), partial response (PR) n=15 (23%), stable disease n=0 and progressive disease (PD) n=9 (14%); 41 (63%) were PET-negative and 24 (37%) were PET-positive.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11725127	The immunofluorescence staining also showed that USP2 co-localized with KRAS in the cytoplasm in MM.1S and RPMI 8226 cells (Fig. 4K).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O"...
PMC11482552	Conclusions: The results obtained from this study show that CCR5 represents a promising molecular marker for the accurate quantification of sample cellularity, confirming its use as a reliable sample adequacy control, thus reducing the risk of “false-negative” results.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8068766	In this study, various bioinformatics approaches were used to determine potentially important biomarkers that have functions in Se-dependent oxidative stress resistance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this",...
PMC11546117	Epithelial growth factor (AF-100-15) was purchased from Peprotech (London, UK).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Epithelial", "growth", "factor", "(", "AF-100", ...
PMC11352311	In 786-O, while cell viability was only mildly inhibited after 100 μM esculin treatment, with a cell viability of 92.28 ± 0.86%, it decreased to 78.12 ± 2.77% at 200 μM and to 63.30 ± 6.39% at 300 μM (Figure 3A).	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4355729	Additionally, more AKT was phosphorylated in 786 and A-704 mutated cells (P < 0.05; P < 0.01), compared with 786-O and A-704 WT cells that had the amount of unchanged AKT (P = 0.54; P = 0.49) (Fig. 5c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", ...
PMC11791203	The compounds identified in the extract through GC-MS analysis (Table 3) were subjected to ADME analysis (Table 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "compo...
PMC10522430	A statistical significance threshold was established at p < 0.05.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "statistical", "significance", "threshold", "was", "established", "at", "p", "<", "0.05", ...
PMC11730000	Twice a week, cells were passaged through a 0.25% trypsin solution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Twice", "a", "week", ",", "cells", "were", "passaged", "through", "a"...
PMC11593713	However, it is unclear which alterations in metabolic parameters and pathways contribute to producing reactive oxygen species (ROS) during viral infections.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC7215722	Intestinal homeostasis is maintained through the integrity of the mucosal barrier formed by epithelial cells and their secretions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Intestinal", "homeostasis", "is", "maintaine...
PMC4277423	Similar observation was also reported in other genes disrupted by lentiviral vectors expressing Cas9 and sgRNAs .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similar", "observation", "was", "also", "reported", "i...
PMC11357960	We calculated the percentage changes in relative mRNA level of 15 SUMO machinery components in PBMC from 105 lung cancer patients as the following formula: [(express value-baseline value)/baseline value]×100%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9878278	Specific primary monoclonal antibodies used were rabbit anti-human against RIG-I (Cell Signaling Cat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Specific", "primary", "monoclonal", "antibodies", "used", "were", "rab...
PMC4270159	Media only [additional].	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Media", "only", "[", "additional", "]", "." ] } ]
PMC10965680	The primary objective of this investigation was to determine the genetic architecture underpinning the indigenous Chinese Xiangdong goat breed, marking its inaugural endeavor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9275501	Cancer will become the leading cause of death in every country in the 21st century and the most important obstacle to extending life expectancy (Sarisozen et al., 2016; Bray et al., 2018).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8903741	Not only that, the band corresponding to the full-sized antibody with the expected size of 166 kDa was seen on the gel in the non-reduced condition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	No CR was observed with IxPd in our series.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "CR", "was", "observed", "with", "IxPd", "in", "our", "series", "." ] } ]
PMC11596967	We examined the protective effects of Ddes-P3 against X-ray-induced apoptosis and necrosis in CHO-K1 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "We", "examined", "the", "protective", "effects", "of", ...
PMC8348645	The morphology of the cell and its viability were observed after inducing the test concentrations of the standard and the samples, i.e., at 72 h. The observation was performed by an inverted light microscope where one can see the viable HepG2 cells in the control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11680391	After the calculations, constructs, C1, C3, and C5 (Supplementary Tables S1 and S2) were eliminated, as well as herd size.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8759873	Ultrasound microbubbles gene transfection method can increase the transfection efficiency of the VHL gene into 786-0 cells within a certain range.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O" ], ...
PMC11700165	The bone marrow-derived pro-B cell line BAF3 was considered a good candidate for this experiment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "bone", "marrow-derived", "pro-B", "cell", "line",...
PMC7519871	In conclusion, the combination of WDL and cisplatin has the potential to work synergistically towards the inhibition of growth of cervical cancer cells in any sequence of application.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Patients received CAR-T cells infusion from May 2015 to August 2018 in Shaanxi Provincial People’s Hospital.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "received", "CAR-T", "cells", "infusio...
PMC11301095	In treatment, amphotericin B is one of the most recognized drugs, utilized in all reported survivor cases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "treatment", ",", "amphoteri...
PMC11696659	In this setting the telomere evaluation could contribute to evaluate the patient during early screening of asymptomatic lung cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "setting", "the", ...
PMC11126803	Cells were cultured in Dulbecco's modified Eagle's medium (DMEM) media with 1% penicillin (25 units/ml) and L-glutamine, containing 10% fetal bovine serum.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11190538

Ltd., Cambridge, UK).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ltd.", ",", "Cambridge", ",", "UK", ")", "." ] } ]

PMC11476004

The comet assay is the cytogenetic test most often used in people and animals.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "comet", "assay", "is", "the", "cytogenetic", "test", "mos...

PMC6889484

In future studies, it may be possible to achieve high levels of lentiviral transduction as well as enable pharmacologic selection of the transduced cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11337594

Despite the initial efficacy of targeted therapies, the emergence of resistance appears to be a common issue associated with these drugs [14–16].

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC9424261

Taken together, we showed that CA can increase the sensitivity of liver cancer cells to ferroptosis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Taken", "together", ",", "we", "showed", "t...

PMC11534035

These results further highlight the significance of PAI1 as a pivotal protein involved in the functional aspects of malignant cells in VC.

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PMC11680562

Xanthan gum consists of extended carbohydrate chains that create a network capable of efficiently trapping water molecules, hence greatly increasing the viscosity of solutions and formulations .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11549612

Methylation analysis via the GSCA database.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methylation", "analysis", "via", "the", "GSCA", "database", "." ] } ]

PMC9429973

Eight underwent Treg/Tcon HSCT (3 from HLA-matched, 5 from HLA-haploidentical donor), while 2 unmanipulated haploidentical HSCT followed by post-transplant cyclophosphamide (PT-Cy).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11802929

Gene expression UMAP (GEX-UMAP) was generated based on scRNAseq.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gene", "expression", "UMAP", "(", "GEX-UMAP", ")", "was", "generated", "based", "on",...

PMC8270637

Fluorescence-conjugated mAbs to CD3 and CD8 were purchased from BD Biosciences (San Jose, CA, USA).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fluorescence-conjugated", "mAbs", "to",...

PMC9429973

Moreover, stroke was more common in MPNs with concomitant HTN (HR=4.24) and HTN was a predictor of ischemic stroke recurrence in MPNs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC10891340

RNA was isolated from infected and uninfected DEFs at different time using TRIzol reagent (Invitrogen, Carlsbad, CA), and the purity and concentration of RNA was determined using a NanoDrop ND-1000 spectrophotometer at a ratio of A260/A280, with ratios between 1.8 and 2.0.

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PMC7057940

Conventional PCR was performed to detect the presence of genes EWS, FLI1 and reciprocal fusion gene FLI1-EWS.

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PMC11591038

Consistently in the brains of adult (50–60 weeks of age) Tg2576 AD mice, immunofluorescence staining of brain microvessels revealed a significantly higher level of HIF-1α along with the heightened expression of pro-angiogenic factors and reduced anti-apoptotic Bcl-xL .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10523483

Mice harboring Kras-driven lung cancer with wild-type H1.2 (Kras; H1c, abbreviated as K) and with H1.2 knockout (Kras; H1c, abbreviated as KH) were used.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11033180

Therefore, we asked whether Sema5A could induce CaMKII or ERK activation by examining their level of phosphorylation at Tyr286 and Thr202/Tyr204, respectively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11655536

B Comparison the expression levels of NHE1 in HD, SMM, MGUS, ND and RR in MM datasets (GSE6477).

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PMC3164356

Pathways are adapted loosely from ref.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pathways", "are", "adapted", "loosely", "from", "ref", "." ] } ]

PMC9429973

All these elements are potential targets for specific interventions by the social system to improve HRQoL in NHL patients.

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PMC8010066

Thus, there was a significant correlation between SA-1 and the viability of P. aeruginosa strains (P-value 0.0001, P-value 0.0002, and P-value 0.0001 for PA-2, PA-3, and PA-4, respectively).

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PMC11745823

In T98G and A‐172 cell lines, sh‐RNAs targeting c‐Myc were employed to further investigate its role in RIT1‐mediated glioma cell proliferation.

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PMC11703992

B The cell viability of different groups of Jurkat cells, including DDIT4-KD/OE/Blank groups and the PMA induced/DDIT4-OE-PMA induced Jurkat cells.

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PMC11698348

PMEKs were cultures and transfected with Controls, pElf5-OE and/or siElf5 as described above.

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PMC9429973

Notably, although minor proportion of proliferating cells were enriched in the end of P4 pseudotime trajectories, clusters could not be split in P4 patients.

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PMC11752767

Therefore, TCR-T is considered another promising ACT modality for advanced melanoma, due to its highly immunogenetic next to the TIL therapy.

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PMC11509309

High-resolution mass spectra were obtained with a Q-TOF mass spectrometer (Synapt XS, Waters Corporation, Milford, NY, USA) at the UBO platform or on a Q-Exactive spectrometer (Thermo Fisher Scientific, Waltham, MA, USA) at the CRMPO platform, both using a direct electrospray infusion (ESI) of the purified compounds di...

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PMC9577200

To determine the turbidity of the bacteria, 200 μl of the diluted cell suspension of each bacterium (OD600 = 0.5) was mixed with 20 μl of various starting GO concentrations (100, 200, 300, 400, 500, 600, and 700 mg ml), various starting levels of CS (0.2, 0.4, 0.6, 0.8, 1, and 1.5%), and the previous different ratios o...

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PMC11098378

Although the absolute fold changes in arbovirus replication varied between our initial screen using pIB/V5-His and our confirmatory screen with pDGOpIE2, the overall trends in SopB rescue were similar (Fig 2B–2E versus Fig 3C–3F).

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PMC11397654

This research indicates that the amphiphilic character of the aggregates improves the selectivity of OHC against cancer cells, with the anticancer activity against human duodenal adenocarcinoma especially worth further research.

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PMC11634027

The RMCE cassette was then replaced by site-specific recombination with either wild-type ds sequences, or with ds sequences in which one of the motifs A-F were deleted.

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PMC9429973

Approximately, 79% of Medicaid patients were admitted to the hospital via the emergency room visit.

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PMC9220170

It has been reported that the downregulation of two important enzymes of the ERAD system in SELENOT-KD results in the accumulation of misfolded proteins in the ER lumen, which appears to exacerbate ER stress in A-172 cancer cells.

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PMC11713609

Scale bar, 1 cm. (

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PMC3019555

Live cell imaging of HeLa–GFP-Ago2 cells treated with 100 µM 2ME2, 1 µM TX, or 30 µM Noc for 1 h. (B) HeLa–GFP-Ago2 (green) cells treated with 25 µM 2ME2 or 50 nM TX overnight, fixed, and stained for GE-1 (red) and α-tubulin (white).

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PMC11585254

The net BRET was calculated by subtracting the BRET ratio from cells transfected with only donor plasmid.

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PMC11680982

Effects of CDK4/6 inhibitor + endocrine therapy and triple combination treatment (neratinib, CDK4/6 inhibitor and endocrine therapy) on HER2 mRNA stability.

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PMC11718817

In a previous paper, we could describe T-cell-intrinsic effects of NLRP3-mediated cytokine signaling .

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PMC9856122

An antiviral study included didehydro-cortistatin and highlighted ‘‘Block-and-lock’’ approach for the treatment of HIV.

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PMC11045125

As expected, Myc expression was dramatically decreased in this cell line after three days of doxycycline treatment.

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PMC10993311

EMILINs are extracellular matrix glycoproteins with regulatory functions in cell migration, differentiation, and proliferation (Zacchigna et al., 2006).

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PMC11291490

Further information on research design is available in the Nature Research Reporting Summary linked to this article.

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PMC4270159

Treatment of a control cell line with the growth factor ligand alone.i.

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PMC5311252

This model is further supported by the fact that ectopic expression of oncomotif-miRNAs results in increased proliferation.

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PMC11144200

E The number of apoptosis cells detection by TUNEL.

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PMC9429973

Methods: Consistent with studies of other R/R DLBCL treatments, identified through a literature review, parametric and mixture cure models were fit utilizing multiple distributions.

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PMC9429973

A total of 14 (87.5%) participants had at least one treatment emergent adverse event (TEAE).

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PMC9429973

These data provide a historical reference for expected outcomes that may serve as a benchmark for the evaluation of novel drugs and combinations in the setting of INO/Blina failure.

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PMC11754432

Whereas, DHA was shown to reduce PPARδ and activate PPARγ, in addition to reducing TNFα secretion and lowering hyperproliferation in skin equivalents .

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PMC9341513

to the region and local chromatin states and DNA accessibility are altered.

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PMC11704834

EGFR-TKI resistance mechanisms include secondary EGFR mutations (for example, T790M), bypass signaling activations (for example, MET amplification) and phenotypic transformation [for example, epithelial-mesenchymal transition (EMT)] (2).

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PMC9429973

Sequencing these options and identifying the optimal choice of treatment for individual patients can be challenging for practicing oncologists.

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PMC11718274

The results of alkaline Comet assay, ROS generation, integrity of mitochondrial membrane potential, qRT-PCR and oxidative stress markers were expressed as mean ± SD and were statistically analyzed using the Statistical Package for the Social Sciences 20 (SPSS 20).

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PMC7081114

However, most HCC patients are diagnosed at advanced stages, and recurrence and metastasis remain major challenges in HCC treatment, leading to an extremely poor prognosis.

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PMC11337594

This was achieved through a dual mechanism involving promotion of cell death and inhibition of cell proliferation.

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PMC10421378

Ch01 contains brightfield images recorded for individual events as they pass through the flow cell.

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PMC9927933

Like UBE2C knockdown, CDH1 knockdown also inactivated mTORC1/2 signaling in all 3 cell lines tested without affecting the MAPK signaling in 2 cell lines (Figure 4B and Supplemental Figure 4B), suggesting that APC/C E3 couples with UBE2C E2 to control the abundance of DEPTOR, thus regulating mTORC1/2 signaling.

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PMC8193046

As indicated above, ABCB1, ABCC1, and ABCG2 are the most investigated and understood ABC transporters, and hence, represent model targets for the generation of pan-ABC transporter inhibitors .

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PMC11098378

A. Six structural homologs of Ceg10, shown in the same orientation with the putative active site near the top of the figure.

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PMC11670407

The electron microscopy results revealed that OTULIN deficiency promoted cisplatin-induced death in osteosarcoma cells, which exhibited a morphology closer to that of apoptotic cells and aggravated mitochondrial damage, including mitochondrial swelling and membrane rupture (Fig. 5h).

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PMC11786600

This technique produces a fibrous membrane with high porosity and good pore interconnectivity, which creates a microenvironment conducive to cellular response and wound healing, inducing more M2 macrophages.13,14 Portable electrospinning filaments, a novel electrospinning filament variant, can rapidly produce films wit...

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PMC11247842

In this study, summary statistics of sequence-based GWAS for CM and SCS were combined with single- and multi-trait meta-analysis methods to identify sequence variants associated with CM, SCS, or both.

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PMC8345486

The effect of prolonged cultivation of cells in a medium with the addition of the compounds was evaluated after removing the medium enriched with the compounds, replacing it with the basal medium, and processing the culture for an additional three days.

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PMC11805741

The control group, with no treatment, exhibited high reduction rates (71.67% at 24 h and 95.67% at 48 h), demonstrating robust cell migration.

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PMC11577421

Cells were cultured in DMEM culture medium supplemented with 10% FBS and 1% penicillin/streptomycin.

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PMC11721295

The average expression values of ligands and receptors in each cell population for both groups (KRAS and non–KRAS-driven) were calculated individually.

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PMC11718817

Addition of macrophages not only as a passive “ingredient” of the spheroid seed but as an active contributor toward intratumoral motility has, to our knowledge, not been shown before.

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PMC11267036

Each experiment was repeated thrice.

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PMC9429973

Results: The study was launched on March 2015 and completed all participants’ planned visits as of Feb 2022 with a median follow-up duration of 27.5 months (range 2-51 months).

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PMC5874706

The 4-methoxy-5-isopropyl-5,6,7,8-tetrahydroindeno[1,2-b]indole-9,10-dione (THN7, Figure 1) was identified as a potent inhibitor of CK2 (IC50 = 71 nM, unpublished data) and then selected for new encapsulation in a set of amphiphilic cyclodextrins (CDs).

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PMC9429973

At EOT, PET response was CR n=41 (63%), partial response (PR) n=15 (23%), stable disease n=0 and progressive disease (PD) n=9 (14%); 41 (63%) were PET-negative and 24 (37%) were PET-positive.

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PMC11725127

The immunofluorescence staining also showed that USP2 co-localized with KRAS in the cytoplasm in MM.1S and RPMI 8226 cells (Fig. 4K).

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PMC11482552

Conclusions: The results obtained from this study show that CCR5 represents a promising molecular marker for the accurate quantification of sample cellularity, confirming its use as a reliable sample adequacy control, thus reducing the risk of “false-negative” results.

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PMC8068766

In this study, various bioinformatics approaches were used to determine potentially important biomarkers that have functions in Se-dependent oxidative stress resistance.

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PMC11546117

Epithelial growth factor (AF-100-15) was purchased from Peprotech (London, UK).

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PMC11352311

In 786-O, while cell viability was only mildly inhibited after 100 μM esculin treatment, with a cell viability of 92.28 ± 0.86%, it decreased to 78.12 ± 2.77% at 200 μM and to 63.30 ± 6.39% at 300 μM (Figure 3A).

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PMC4355729

Additionally, more AKT was phosphorylated in 786 and A-704 mutated cells (P < 0.05; P < 0.01), compared with 786-O and A-704 WT cells that had the amount of unchanged AKT (P = 0.54; P = 0.49) (Fig. 5c).

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PMC11791203

The compounds identified in the extract through GC-MS analysis (Table 3) were subjected to ADME analysis (Table 4).

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PMC10522430

A statistical significance threshold was established at p < 0.05.

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PMC11730000

Twice a week, cells were passaged through a 0.25% trypsin solution.

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PMC11593713

However, it is unclear which alterations in metabolic parameters and pathways contribute to producing reactive oxygen species (ROS) during viral infections.

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PMC7215722

Intestinal homeostasis is maintained through the integrity of the mucosal barrier formed by epithelial cells and their secretions.

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PMC4277423

Similar observation was also reported in other genes disrupted by lentiviral vectors expressing Cas9 and sgRNAs .

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PMC11357960

We calculated the percentage changes in relative mRNA level of 15 SUMO machinery components in PBMC from 105 lung cancer patients as the following formula: [(express value-baseline value)/baseline value]×100%.

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PMC9878278

Specific primary monoclonal antibodies used were rabbit anti-human against RIG-I (Cell Signaling Cat.

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PMC4270159

Media only [additional].

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PMC10965680

The primary objective of this investigation was to determine the genetic architecture underpinning the indigenous Chinese Xiangdong goat breed, marking its inaugural endeavor.

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PMC9275501

Cancer will become the leading cause of death in every country in the 21st century and the most important obstacle to extending life expectancy (Sarisozen et al., 2016; Bray et al., 2018).

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PMC8903741

Not only that, the band corresponding to the full-sized antibody with the expected size of 166 kDa was seen on the gel in the non-reduced condition.

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PMC9429973

No CR was observed with IxPd in our series.

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PMC11596967

We examined the protective effects of Ddes-P3 against X-ray-induced apoptosis and necrosis in CHO-K1 cells.

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PMC8348645

The morphology of the cell and its viability were observed after inducing the test concentrations of the standard and the samples, i.e., at 72 h. The observation was performed by an inverted light microscope where one can see the viable HepG2 cells in the control.

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PMC11680391

After the calculations, constructs, C1, C3, and C5 (Supplementary Tables S1 and S2) were eliminated, as well as herd size.

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PMC8759873

Ultrasound microbubbles gene transfection method can increase the transfection efficiency of the VHL gene into 786-0 cells within a certain range.

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PMC11700165

The bone marrow-derived pro-B cell line BAF3 was considered a good candidate for this experiment.

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PMC7519871

In conclusion, the combination of WDL and cisplatin has the potential to work synergistically towards the inhibition of growth of cervical cancer cells in any sequence of application.

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PMC9429973

Patients received CAR-T cells infusion from May 2015 to August 2018 in Shaanxi Provincial People’s Hospital.

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PMC11301095

In treatment, amphotericin B is one of the most recognized drugs, utilized in all reported survivor cases.

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PMC11696659

In this setting the telomere evaluation could contribute to evaluate the patient during early screening of asymptomatic lung cancer.

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PMC11126803

Cells were cultured in Dulbecco's modified Eagle's medium (DMEM) media with 1% penicillin (25 units/ml) and L-glutamine, containing 10% fetal bovine serum.

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