OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11155445	Leaching is one of the most prominent pathways to extract ores and consequently precious metals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Leaching", "is", "one", "of", "the", "most", "prominent", ...
PMC11541409	This reference also implies that anlotinib may have similar efficacy to sunitinib.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "reference", "also", "implies", "that", "anlotinib", "may", "have", "simi...
PMC11538390	Statistical significance is determined by Student’s t test (two-tailed).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "significance", "is", "determined", "by", "Student", "’s", "t", "t...
PMC9429973	Finally, we analyzed the expression of sEV-related genes in a cohort of 144 CLL patients using qPCR followed by regression analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",...
PMC9065483	Supernatants were collected and titered by viral plaque assay (n = 3, mean ± SD; ∗p < 0.05, p < 0.0001; one-way ANOVA compared with the infected VSVΔ51 + vanadate only condition as indicated by the filled bar). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11583010	The ETx-22 antitumor effect was higher and more durable than EV.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ETx-22", "antitumor", "effect", "was", "higher", "and", "more", "durable", "th...
PMC11791478	Effect of 25A3 on the coagulation cascade.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Effect", "of", "25A3", "on", "the", "coagulation", "cascade", "." ] } ]
PMC11730000	DOX hydrochloride, RA, and (-) -EGCG (Sigma-Aldrich, USA) were dissolved in phosphate-buffered saline (PBS) (Gibco, USA) to prepare a master stock solution and stored in -20 °C before use.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10362265	The final model was confirmed to be free of Ramachandran outliers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "final", "model", "was", "confirmed", "to", "be", "free", "of", "Ramachandran",...
PMC11699178	These findings provide essential molecular targets and a theoretical foundation for the development of novel treatment strategies for ovarian cancer in the future.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These",...
PMC11694346	As shown in Fig. 3, the absorption spectra revealed minimal differences with and without biothiols, suggesting consistent dye behavior irrespective of biothiol presence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11055323	The construction process was described in the method of Hi-C data analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "construction", "process", "was", "described", "in", "the", "method", "of"...
PMC9243326	Furthermore, we also predicted the TFs of C. chinensis and obtained detailed TF numbers and family classifications, among which the zf-c2h2 family was the most abundant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6835428	Often, but not always, the two strategies are combined together.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Often", ",", "but", "not", "always", ",", "the", "two", "strategies", "are...
PMC11394112	We observed STAT3 activation in U2932 cells after 1 h incubation with human IL6, in agreement with the previous report, and further showed that phosphorylation of STAT3 (pSTAT3) is inducible at a higher abundance after 30 min (Figure 4A).	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11672881	This indicates an enhanced cellular response to stress and damage repair mechanisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "indicates", "an", "enhanced", "cellular", "response", "to", "stress", "a...
PMC11489351	However, prior work is conflicting on the role for pHi in directly altering metabolism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "prior", "work", "is", "conflicting", "on", ...
PMC6901583	CD14 macrophages constituted over 95% of the adherent cells using this approach.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CD14", "macrophages", "constituted", "over", "95", "%", "of", "the", ...
PMC11291490	The resulting mixture was added to BHK-21 cells cultured in 96-well plates with approximately 90% confluence, at a volume of 100 μL per well.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: The best overall response rate to PD-1 inhibitor therapy was 70%: 47% complete remission (CR) and 23% partial remission (PR).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Mortality rate decreased depending on vaccination status, being 34.2% in not vaccinated patients, 15.9-18% with one or two doses, decreasing to 9.7% in patients with booster dose (p<0.001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9065483	Fluorescence images were captured 24 hpi. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fluorescence", "images", "were", "captured", "24", "hpi", ".", "(" ] } ]
PMC11718109	A Fluorescence image of DA neurons (day 55) immunolabeled with antibodies directed against VGLUT2 (green) and synapsin (magenta).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11394112	Blots were imaged using the Biorad ChemiDoc MP (BIO-RAD, Hercules, CA, USA), and images were analyzed using Image Lab software v6.1 (BIO-RAD).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11469524	A previous study attempted to infer an oncogenic signaling network in aggressive lymphoma cell lines indirectly from gene expression data following signaling perturbations using the Boolean Nested Effects Modeling (B-NEM) approach.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11637276	Moreover, MAPK11 down-regulation by 3 individual siRNAs sequences significantly impaired collagen I uptake (S7 Fig), indicating it is an on-target hit as MAP3K1 and PPP2R1A (Fig 1F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7759933	Altogether, these results demonstrate that HepG2 cells grown in 3D conformation show differentiation into more metabolically competent cells when compared to monolayer cultures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "token...
PMC11252033	feature Counts v1.5.0-p3 was used to count the reads numbers mapped to each gene and then Fragments Per Kilobase Million (FPKM) of each gene was calculated based on the length of the gene and reads count mapped to this gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11632064	C, D) Functional gene analysis on differentially expressed transcripts in MeWo cells treated with BI-D1870 for 72 h compared to DMSO. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "token...
PMC11767582	for C17H17N4O5 [M+H]: 357.1193, found: 357.1183.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "for", "C17H17N4O5", "[", "M+H", "]", ":", "357.1193", ",", "found", ":", "357.1...
PMC11772585	As a well-known methyltransferase, METTL1 is overexpressed in various tumor tissues and cell lines .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "a", "well-known", "methyltransferase", ",", "METTL1", ...
PMC11707577	We tested in vitro the performances of M13EGFR(TNP) in photodynamic therapy (PDT) using 2D and 3D cellular models.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "tested", "i...
PMC11741906	Median survival for 486 ovarian cancer patients was analyzed after categorizing samples into high (red) or low (black) expression groups for each miRNA (A–D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	I. Schwaner, H. Hebart, C. Losem, T. Wolff, K. Famulla, J. Huelsenbeck, B. Schmidt, T. Nösslinger, D. Rossi Onkologie Kurfürstendamm, Berlin; Kliniken Ostalb, Mutlangen; MVZ Onkologie und Hämatologie, Neuss; Onkologie Lerchenfeld, Hamburg; AbbVie Deutschland GmbH & Co KG, Wiesbaden; Hämatologisch-Onkologische Gemeinsch...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11648299	Decreased SERCA activity could cause increased entry of calcium which may affect cell proliferation and resistance to apoptosis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Decreased", "SERCA", "activity", "could", ...
PMC11699465	The Tumors were surgically removed after various administrations for further estimation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Tumors", "were", "surgically", "removed", "after", "various", "administrations", "fo...
PMC11406030	The mice were intravenously administered 2 mg/kg doses of LMTK3BP #1, #2, and #3 to test their efficacy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11607638	Samples were taken immediately after weighing and blood‐feeding experiment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Samples", "were", "taken", "immediately", "after", "weighing", "and", "blood‐feeding", "experiment", "." ...
PMC11612626	Data were analyzed using FlowJo software (version 10.9.0).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "were", "analyzed", "using", "FlowJo", "software", "(", "version", "10.9.0", ")", "...
PMC11525028	NAT10 overexpression is correlated with a poor prognosis, and NAT10 knockout inhibits osteosarcoma progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NAT10", "overexpression", "is", "correlated", "with", "a", ...
PMC11413393	Read counts per gene were subsequently obtained using the htseq-count command in the HTSeq v0.11.0 package alongside Gencode’s human genome annotation release 44.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11589157	The latest report on T2T genomes of five great apes includes a new assembly for the Y-chromosome of S. syndactylus, with a gapless length of ~30 Mb.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11512230	Although the colleagues did not continue their research with TMV SP, based on the data obtained in the work, we believe that the potential of using structurally modified particles as a platform for drug development and delivery is far from exhausted.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10890055	We also compared the sensitivity of the hFOB 1.19 and L929 cell lines to Zn (Figure 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "compare...
PMC5673955	P ≤ 0.05 versus control cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "≤", "0.05", "versus", "control", "cells", "." ] } ]
PMC11766309	P < 0.05, P < 0.01, P < 0.001, ***P < 0.0001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11240448	The DPD modules are governed by two different types of forces: the signaling force and the gradient restoring force.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "DPD", "modules", ...
PMC11536589	On the day 3 following subcutaneous, mice were administrated with 1 mg/Kg MRTX1133 through intraperitoneal injection once every day, 1 mg/Kg PKF-118-310 through intratumoral injection once every three days, or combined treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612508	Following this, 15 mL of S. officinalis leaf extract in aqueous form was added to the mixture of metal salts while stirring continuously.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11055443	The production of NO and TNF-α, IL-1β, and IL-8 pro-inflammatory cytokines were significantly (P<0.05) reduced in exposure to the secretome of AD-MSCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11756907	The transcutaneous GO diffusion test was implemented using a Strat-M membrane (Merck Poland), which makes it possible to predict the diffusion of substances in human skin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10170482	Importantly, there were no concomitant changes in the expression of any genes related to drug metabolism enzymes (Table S5) or inflammation-related genes (Table S6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11185260	For the cell culture experiments, the complex was further diluted with serum-free medium and added to the culture.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "the", "cell", "culture", ...
PMC10854447	H NMR (400 MHz, δ ppm DMSO-d6): 8.81 (s, 1H, triazole-CH), 7.89 (d, J = 7 Hz, 2H, Ar–H), 7.48 (t, J = 7.5 Hz, 2H, Ar–H), 7.37 (t, J = 7.4 Hz, 1H, Ar–H), 7.26 (s, 2H, Ar–H), 6.27 (s, 2H, N–CH2), 3.85 (s, 6H, Ar–(OCH3)2), 3.74 (s, 3H, Ar–OCH3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6182045	The panel of 10 clade C, gD tagged envelope proteins was expressed in HEK 293 cells as described previously (17).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC9429973	However, gaps in knowledge do remain, particularly for T-cell lymphomas, which warrants further education to help address these needs and continue supporting the improvement of patient outcomes with these hematological malignancies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11171319	Interestingly both high-risk HCMV-DB and BL strains dedifferentiated primary mature human astrocytes into neural-progenitor-like tumor cells similar to the cells detected in glioblastoma, especially the ones adopting the Lévy-like movement patterns .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5173112	Expression levels were normalized to glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression, as previously described .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Expression", "levels", "were", "normalized", "to", "glyceraldehyd...
PMC8345486	The higher the accumulation of the compounds, the higher the cytotoxic effect, as revealed by the majority of the compounds studied, with few exceptions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11770130	The fact that the depletion of Nts in LECs had no effects on food intake indicated potential existence of endogenous ligands for NTSR2 other than NTS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11775197	The authors finally found that combining rosiglitazone with radiotherapy effectively inhibited angiogenesis, distant metastatic potential, and tumor recurrence .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "authors", "finally", ...
PMC11290772	All the collection work were performed under full acknowledgments and agreements of the patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "the", "collection", "work", "were", "performed", "under", ...
PMC11001582	f, Representative EDL MUNE traces from 12-month-old WT (left panel), (GR)400 (center panel) and (PR)400 (right panel) mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11715644	Microchannels of polydimethylsiloxane (PDMS, Sylgard 184; Dow Corning, Midland, MI) were fabricated following the standard procedures of soft lithography, as depicted in Fig. 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7757104	In the lung cancer cell line A549, Huang et al (39) have demonstrated that OPNc overexpression induces increased cell migration and invasion, and alters the expression of EMT markers (decreases E-cadherin and increases vimentin expression) in response to TGF-β treatment, indicating that OPNc stimulates cellular plastic...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11464982	■■■■■ a product that may cause allergies or intolerances (listed in the Regulation (EU) No 1169/2011 ) is used as raw material.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9847912	For HIV-2 isolates ROD9, ST, and 7312A, as well as SIVmac239 and SIVmac251, the corresponding dose-response plots tended to show a gradual decrease in the level of infectious virus at GSK232 concentrations >10 nM, suggesting that the drug exerts weak antiviral activity against HIV-2 and SIV in 293T/17 cells (S4 Fig).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11138140	Overall, leveraging the unique advantages of the Holomonitor M4 digital holographic imaging system has the potential to empower future work towards understanding the molecular and cellular mechanisms underlying cardiomyocyte hypertrophy with enhanced temporal clarity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11670407	Osteosarcoma cells were cultured into 96-well plates at a density of 5,000 cells per well, and each set of experiments was repeated in five wells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC2118063	Transcriptional down-regulation of Bcl6 appears to be required for B cells to exit the GC, and our experiments indicate that this may be caused by synchronous reductions in the expression of IRF8 and activation of BLIMP1, a transcriptional repressor of Bcl6 (2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11803918	They can not only directly induce cancer cell apoptosis but also promote the antitumor αβ-T-cell response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "can", "not", "only", "directly", "induce", ...
PMC11190238	Vimentin-based intermediate filaments are present in mesenchymal cells, and they use integrin-containing focal adhesions to attach to the extracellular matrix.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Vimentin-based", "inter...
PMC10419319	The evaluation of the effect of isoalantolactone on apoptosis-related proteins revealed that isoalantolactone increased the expression of cleaved caspase-3, caspase-8, and PARP1 and decreased the expression of anti-apoptotic genes such as cyclin D1 and mcl-1 (Figure 3B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11518702	Isoforms of C1ORF150, and HGAL (translated from validated transcripts) including urticaria associated C1ORF150 “isoform B”.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Isoforms", "of", "C1ORF150",...
PMC9429973	Results: The prevalence, univariate HR, and 2-year PFS estimates of BCL2+/MYC+ and BCL2-R/MYC-R/BCL6-R subgroups are presented (Table) except for BCL6-R, because all four PFS events in this subgroup were with Pola-R-CHP.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6799808	To determine the pathways involved in the observed apoptosis, we first investigated whether GLPT-induced apoptosis occurs through the mitochondrial pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "determine", ...
PMC9429973	For pts who fulfilled the criteria of a successful induction treatment, detection of MRD in either BMMC or PBMC in CR/CRi pts at the end of induction was associated with significantly lower event free survival (EFS) and overall survival (OS) compared to MRD status (1-year EFS of 26% vs 72% in BMMC and 34% vs 71% in PBM...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11637284	This was a plausible prediction as the interacting segment of TAC60 is located right in the center of the IMS loop (Fig 1D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11126803	The next day, anti-rabbit or anti-mouse IgG secondary antibody was used at a concentration of 1:5000 for 2 h at room temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC10606998	The formation of ROS was determined by the intensity of fluorescence after the addition of the reagent (Fluorometric Intracellular ROS Kit) as described in Section 4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5173112	Next, we examined whether USP21 maintain the self-renewal properties of CSCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", ",", "we", "examined", "whether", "USP21", "maintain", "the", "self-renew...
PMC10197932	The system used to generate ultrasound is the KTAC-400 Sonoporation System (Nepa Gene, Japan).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "system", "used", "to", "generate", "...
PMC11438317	Using this approach, we identified a group of adaptor proteins critical for TCR signaling, including FYB, SLP76, SKAP1, HS1, and Vav.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11585254	However, in the β-arrestin1/2 DKO cell line, there was a ∼25% decrease in internalization relative to the WT receptor (Fig. 5C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11638255	Tumor microenvironment (TME) data (excluding TGF-β) are presented as mean ± SEM, n = 10 (Control) and n = 6 (TEPA) biological replicates, one independent experiment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11240571	After 4 h, an enzyme-linked immunosorbent assay was performed using human IFN-γ (Human IFN-gamma Sandwich ELISA Kit, Proteintech, Tokyo, Japan, cat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8389560	SeNP in MCF–7 cancer cells cause an increase in the expression of cytochrome C, Bax, and P—p38, a decrease in CD44, which leads to disorganization and dysregulation of intracellular cytoskeleton F-actin, and induction of apoptosis and necrosis .	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10551595	Despite the supposed loss of function in CCRF‐CEM cells, TP53 showed increased expression levels and functional activity upon treatment with GingernoneA. Bioinformatic studies revealed the conceivable impact of GingerenoneA on the reactivity of mutant P53 through its binding to Cys124.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11291490	The final group of ducks received an intramuscular injection of 0.5 mL of inactivated TMUV vaccine (Yangzhou Ubang Biopharmaceutical Co., China) in the lateral thigh.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11266100	The results were analysed using FlowJo software (BD, Becton Drive Franklin Lakes, NJ, United States).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "were", ...
PMC11575040	Cell cycle distribution analysis of cell population after LINC00094 knockdown (Fig. 4A–D) revealed a significant increase in sub-G1 and G1 phase A2058 and A375 melanoma cells after 72 h of incubation, along with a significant decrease in S and G2/M phase cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", ...
PMC11499381	Cell-markers were not included in analyses and thus results from experiments using the different dyes were able to be compared.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell-markers", "were", "not"...
PMC9429973	GSEA analysis of major pathways showed down-regulation of those related to cell cycles (including E2F targets), innate immunity, and TNFα signaling via NFκB. Gene ontology analysis also revealed down-regulation of cell cycle-related pathways, further supporting the significance of the down-regulated cell cycles in der(...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11772585	Tumor tissues were initially fixed in 10% formaldehyde for 24 h. Subsequently, paraffin embedding was carried out, and paraffin sections were generated, followed by a 2-h deparaffinization process in dimethylbenzene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10495912	Cytotoxicity assay As shown in Figure 3, the IC50 for TQ (Figure 3-A) and hydrogen peroxide (Figure 3-B) were determined to be 192.3 µM and 309.1 µM, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10940855	F, Heat map of differentially expressed genes in HAECs versus HDECs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "F", ",", "Heat", "map", "of", "differentially", "expressed", "genes", "in", ...
PMC11539788	The results suggested that RNF19A expression was significantly decreased in BCa tissues compared to adjacent normal tissues (Fig. 1D-G), which was consistent with findings from the public databases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	One (2.8%) had mutations of NRAS and PTPN11, and 8 (22.2%) had no known JMML mutants.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", ...
PMC7338939	Thus, in order to find a systematic method for determining the optimal amount of DAPT for every injection, the optimal control theory was applied.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9545474	Complexes 6–8 show significantly high cytotoxicity (nanomolar and low micromolar range) for the tested cell lines indicating that the presence of the triphenylphosphine moiety in the complexes is important for the cancer‐inhibiting properties of the compounds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11155445

Leaching is one of the most prominent pathways to extract ores and consequently precious metals.

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PMC11541409

This reference also implies that anlotinib may have similar efficacy to sunitinib.

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PMC11538390

Statistical significance is determined by Student’s t test (two-tailed).

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PMC9429973

Finally, we analyzed the expression of sEV-related genes in a cohort of 144 CLL patients using qPCR followed by regression analysis.

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PMC9065483

Supernatants were collected and titered by viral plaque assay (n = 3, mean ± SD; ∗p < 0.05, p < 0.0001; one-way ANOVA compared with the infected VSVΔ51 + vanadate only condition as indicated by the filled bar). (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11583010

The ETx-22 antitumor effect was higher and more durable than EV.

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PMC11791478

Effect of 25A3 on the coagulation cascade.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Effect", "of", "25A3", "on", "the", "coagulation", "cascade", "." ] } ]

PMC11730000

DOX hydrochloride, RA, and (-) -EGCG (Sigma-Aldrich, USA) were dissolved in phosphate-buffered saline (PBS) (Gibco, USA) to prepare a master stock solution and stored in -20 °C before use.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10362265

The final model was confirmed to be free of Ramachandran outliers.

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PMC11699178

These findings provide essential molecular targets and a theoretical foundation for the development of novel treatment strategies for ovarian cancer in the future.

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PMC11694346

As shown in Fig. 3, the absorption spectra revealed minimal differences with and without biothiols, suggesting consistent dye behavior irrespective of biothiol presence.

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PMC11055323

The construction process was described in the method of Hi-C data analysis.

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PMC9243326

Furthermore, we also predicted the TFs of C. chinensis and obtained detailed TF numbers and family classifications, among which the zf-c2h2 family was the most abundant.

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PMC6835428

Often, but not always, the two strategies are combined together.

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PMC11394112

We observed STAT3 activation in U2932 cells after 1 h incubation with human IL6, in agreement with the previous report, and further showed that phosphorylation of STAT3 (pSTAT3) is inducible at a higher abundance after 30 min (Figure 4A).

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PMC11672881

This indicates an enhanced cellular response to stress and damage repair mechanisms.

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PMC11489351

However, prior work is conflicting on the role for pHi in directly altering metabolism.

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PMC6901583

CD14 macrophages constituted over 95% of the adherent cells using this approach.

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PMC11291490

The resulting mixture was added to BHK-21 cells cultured in 96-well plates with approximately 90% confluence, at a volume of 100 μL per well.

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PMC9429973

Results: The best overall response rate to PD-1 inhibitor therapy was 70%: 47% complete remission (CR) and 23% partial remission (PR).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Mortality rate decreased depending on vaccination status, being 34.2% in not vaccinated patients, 15.9-18% with one or two doses, decreasing to 9.7% in patients with booster dose (p<0.001).

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PMC9065483

Fluorescence images were captured 24 hpi. (

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PMC11718109

A Fluorescence image of DA neurons (day 55) immunolabeled with antibodies directed against VGLUT2 (green) and synapsin (magenta).

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PMC11394112

Blots were imaged using the Biorad ChemiDoc MP (BIO-RAD, Hercules, CA, USA), and images were analyzed using Image Lab software v6.1 (BIO-RAD).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11469524

A previous study attempted to infer an oncogenic signaling network in aggressive lymphoma cell lines indirectly from gene expression data following signaling perturbations using the Boolean Nested Effects Modeling (B-NEM) approach.

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PMC11637276

Moreover, MAPK11 down-regulation by 3 individual siRNAs sequences significantly impaired collagen I uptake (S7 Fig), indicating it is an on-target hit as MAP3K1 and PPP2R1A (Fig 1F).

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PMC7759933

Altogether, these results demonstrate that HepG2 cells grown in 3D conformation show differentiation into more metabolically competent cells when compared to monolayer cultures.

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PMC11252033

feature Counts v1.5.0-p3 was used to count the reads numbers mapped to each gene and then Fragments Per Kilobase Million (FPKM) of each gene was calculated based on the length of the gene and reads count mapped to this gene.

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PMC11632064

C, D) Functional gene analysis on differentially expressed transcripts in MeWo cells treated with BI-D1870 for 72 h compared to DMSO. (

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PMC11767582

for C17H17N4O5 [M+H]: 357.1193, found: 357.1183.

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PMC11772585

As a well-known methyltransferase, METTL1 is overexpressed in various tumor tissues and cell lines .

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PMC11707577

We tested in vitro the performances of M13EGFR(TNP) in photodynamic therapy (PDT) using 2D and 3D cellular models.

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PMC11741906

Median survival for 486 ovarian cancer patients was analyzed after categorizing samples into high (red) or low (black) expression groups for each miRNA (A–D).

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PMC9429973

I. Schwaner, H. Hebart, C. Losem, T. Wolff, K. Famulla, J. Huelsenbeck, B. Schmidt, T. Nösslinger, D. Rossi Onkologie Kurfürstendamm, Berlin; Kliniken Ostalb, Mutlangen; MVZ Onkologie und Hämatologie, Neuss; Onkologie Lerchenfeld, Hamburg; AbbVie Deutschland GmbH & Co KG, Wiesbaden; Hämatologisch-Onkologische Gemeinsch...

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PMC11648299

Decreased SERCA activity could cause increased entry of calcium which may affect cell proliferation and resistance to apoptosis .

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PMC11699465

The Tumors were surgically removed after various administrations for further estimation.

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PMC11406030

The mice were intravenously administered 2 mg/kg doses of LMTK3BP #1, #2, and #3 to test their efficacy.

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PMC11607638

Samples were taken immediately after weighing and blood‐feeding experiment.

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PMC11612626

Data were analyzed using FlowJo software (version 10.9.0).

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PMC11525028

NAT10 overexpression is correlated with a poor prognosis, and NAT10 knockout inhibits osteosarcoma progression.

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PMC11413393

Read counts per gene were subsequently obtained using the htseq-count command in the HTSeq v0.11.0 package alongside Gencode’s human genome annotation release 44.

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PMC11589157

The latest report on T2T genomes of five great apes includes a new assembly for the Y-chromosome of S. syndactylus, with a gapless length of ~30 Mb.

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PMC11512230

Although the colleagues did not continue their research with TMV SP, based on the data obtained in the work, we believe that the potential of using structurally modified particles as a platform for drug development and delivery is far from exhausted.

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PMC10890055

We also compared the sensitivity of the hFOB 1.19 and L929 cell lines to Zn (Figure 3).

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PMC5673955

P ≤ 0.05 versus control cells.

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PMC11766309

P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

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PMC11240448

The DPD modules are governed by two different types of forces: the signaling force and the gradient restoring force.

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PMC11536589

On the day 3 following subcutaneous, mice were administrated with 1 mg/Kg MRTX1133 through intraperitoneal injection once every day, 1 mg/Kg PKF-118-310 through intratumoral injection once every three days, or combined treatment.

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PMC11612508

Following this, 15 mL of S. officinalis leaf extract in aqueous form was added to the mixture of metal salts while stirring continuously.

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PMC11055443

The production of NO and TNF-α, IL-1β, and IL-8 pro-inflammatory cytokines were significantly (P<0.05) reduced in exposure to the secretome of AD-MSCs.

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PMC11756907

The transcutaneous GO diffusion test was implemented using a Strat-M membrane (Merck Poland), which makes it possible to predict the diffusion of substances in human skin.

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PMC10170482

Importantly, there were no concomitant changes in the expression of any genes related to drug metabolism enzymes (Table S5) or inflammation-related genes (Table S6).

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PMC11185260

For the cell culture experiments, the complex was further diluted with serum-free medium and added to the culture.

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PMC10854447

H NMR (400 MHz, δ ppm DMSO-d6): 8.81 (s, 1H, triazole-CH), 7.89 (d, J = 7 Hz, 2H, Ar–H), 7.48 (t, J = 7.5 Hz, 2H, Ar–H), 7.37 (t, J = 7.4 Hz, 1H, Ar–H), 7.26 (s, 2H, Ar–H), 6.27 (s, 2H, N–CH2), 3.85 (s, 6H, Ar–(OCH3)2), 3.74 (s, 3H, Ar–OCH3).

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PMC6182045

The panel of 10 clade C, gD tagged envelope proteins was expressed in HEK 293 cells as described previously (17).

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PMC9429973

However, gaps in knowledge do remain, particularly for T-cell lymphomas, which warrants further education to help address these needs and continue supporting the improvement of patient outcomes with these hematological malignancies.

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PMC11171319

Interestingly both high-risk HCMV-DB and BL strains dedifferentiated primary mature human astrocytes into neural-progenitor-like tumor cells similar to the cells detected in glioblastoma, especially the ones adopting the Lévy-like movement patterns .

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PMC5173112

Expression levels were normalized to glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression, as previously described .

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PMC8345486

The higher the accumulation of the compounds, the higher the cytotoxic effect, as revealed by the majority of the compounds studied, with few exceptions.

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PMC11770130

The fact that the depletion of Nts in LECs had no effects on food intake indicated potential existence of endogenous ligands for NTSR2 other than NTS.

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PMC11775197

The authors finally found that combining rosiglitazone with radiotherapy effectively inhibited angiogenesis, distant metastatic potential, and tumor recurrence .

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PMC11290772

All the collection work were performed under full acknowledgments and agreements of the patients.

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PMC11001582

f, Representative EDL MUNE traces from 12-month-old WT (left panel), (GR)400 (center panel) and (PR)400 (right panel) mice.

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PMC11715644

Microchannels of polydimethylsiloxane (PDMS, Sylgard 184; Dow Corning, Midland, MI) were fabricated following the standard procedures of soft lithography, as depicted in Fig. 1.

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PMC7757104

In the lung cancer cell line A549, Huang et al (39) have demonstrated that OPNc overexpression induces increased cell migration and invasion, and alters the expression of EMT markers (decreases E-cadherin and increases vimentin expression) in response to TGF-β treatment, indicating that OPNc stimulates cellular plastic...

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PMC11464982

■■■■■ a product that may cause allergies or intolerances (listed in the Regulation (EU) No 1169/2011 ) is used as raw material.

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PMC9847912

For HIV-2 isolates ROD9, ST, and 7312A, as well as SIVmac239 and SIVmac251, the corresponding dose-response plots tended to show a gradual decrease in the level of infectious virus at GSK232 concentrations >10 nM, suggesting that the drug exerts weak antiviral activity against HIV-2 and SIV in 293T/17 cells (S4 Fig).

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PMC11138140

Overall, leveraging the unique advantages of the Holomonitor M4 digital holographic imaging system has the potential to empower future work towards understanding the molecular and cellular mechanisms underlying cardiomyocyte hypertrophy with enhanced temporal clarity.

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PMC11670407

Osteosarcoma cells were cultured into 96-well plates at a density of 5,000 cells per well, and each set of experiments was repeated in five wells.

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PMC2118063

Transcriptional down-regulation of Bcl6 appears to be required for B cells to exit the GC, and our experiments indicate that this may be caused by synchronous reductions in the expression of IRF8 and activation of BLIMP1, a transcriptional repressor of Bcl6 (2).

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PMC11803918

They can not only directly induce cancer cell apoptosis but also promote the antitumor αβ-T-cell response.

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PMC11190238

Vimentin-based intermediate filaments are present in mesenchymal cells, and they use integrin-containing focal adhesions to attach to the extracellular matrix.

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PMC10419319

The evaluation of the effect of isoalantolactone on apoptosis-related proteins revealed that isoalantolactone increased the expression of cleaved caspase-3, caspase-8, and PARP1 and decreased the expression of anti-apoptotic genes such as cyclin D1 and mcl-1 (Figure 3B).

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PMC11518702

Isoforms of C1ORF150, and HGAL (translated from validated transcripts) including urticaria associated C1ORF150 “isoform B”.

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PMC9429973

Results: The prevalence, univariate HR, and 2-year PFS estimates of BCL2+/MYC+ and BCL2-R/MYC-R/BCL6-R subgroups are presented (Table) except for BCL6-R, because all four PFS events in this subgroup were with Pola-R-CHP.

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PMC6799808

To determine the pathways involved in the observed apoptosis, we first investigated whether GLPT-induced apoptosis occurs through the mitochondrial pathway.

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PMC9429973

For pts who fulfilled the criteria of a successful induction treatment, detection of MRD in either BMMC or PBMC in CR/CRi pts at the end of induction was associated with significantly lower event free survival (EFS) and overall survival (OS) compared to MRD status (1-year EFS of 26% vs 72% in BMMC and 34% vs 71% in PBM...

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PMC11637284

This was a plausible prediction as the interacting segment of TAC60 is located right in the center of the IMS loop (Fig 1D).

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PMC11126803

The next day, anti-rabbit or anti-mouse IgG secondary antibody was used at a concentration of 1:5000 for 2 h at room temperature.

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PMC10606998

The formation of ROS was determined by the intensity of fluorescence after the addition of the reagent (Fluorometric Intracellular ROS Kit) as described in Section 4.

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PMC5173112

Next, we examined whether USP21 maintain the self-renewal properties of CSCs.

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PMC10197932

The system used to generate ultrasound is the KTAC-400 Sonoporation System (Nepa Gene, Japan).

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PMC11438317

Using this approach, we identified a group of adaptor proteins critical for TCR signaling, including FYB, SLP76, SKAP1, HS1, and Vav.

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PMC11585254

However, in the β-arrestin1/2 DKO cell line, there was a ∼25% decrease in internalization relative to the WT receptor (Fig. 5C).

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PMC11638255

Tumor microenvironment (TME) data (excluding TGF-β) are presented as mean ± SEM, n = 10 (Control) and n = 6 (TEPA) biological replicates, one independent experiment.

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PMC11240571

After 4 h, an enzyme-linked immunosorbent assay was performed using human IFN-γ (Human IFN-gamma Sandwich ELISA Kit, Proteintech, Tokyo, Japan, cat.

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PMC8389560

SeNP in MCF–7 cancer cells cause an increase in the expression of cytochrome C, Bax, and P—p38, a decrease in CD44, which leads to disorganization and dysregulation of intracellular cytoskeleton F-actin, and induction of apoptosis and necrosis .

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PMC10551595

Despite the supposed loss of function in CCRF‐CEM cells, TP53 showed increased expression levels and functional activity upon treatment with GingernoneA. Bioinformatic studies revealed the conceivable impact of GingerenoneA on the reactivity of mutant P53 through its binding to Cys124.

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PMC11291490

The final group of ducks received an intramuscular injection of 0.5 mL of inactivated TMUV vaccine (Yangzhou Ubang Biopharmaceutical Co., China) in the lateral thigh.

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PMC11266100

The results were analysed using FlowJo software (BD, Becton Drive Franklin Lakes, NJ, United States).

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PMC11575040

Cell cycle distribution analysis of cell population after LINC00094 knockdown (Fig. 4A–D) revealed a significant increase in sub-G1 and G1 phase A2058 and A375 melanoma cells after 72 h of incubation, along with a significant decrease in S and G2/M phase cells.

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PMC11499381

Cell-markers were not included in analyses and thus results from experiments using the different dyes were able to be compared.

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PMC9429973

GSEA analysis of major pathways showed down-regulation of those related to cell cycles (including E2F targets), innate immunity, and TNFα signaling via NFκB. Gene ontology analysis also revealed down-regulation of cell cycle-related pathways, further supporting the significance of the down-regulated cell cycles in der(...

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PMC11772585

Tumor tissues were initially fixed in 10% formaldehyde for 24 h. Subsequently, paraffin embedding was carried out, and paraffin sections were generated, followed by a 2-h deparaffinization process in dimethylbenzene.

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PMC10495912

Cytotoxicity assay As shown in Figure 3, the IC50 for TQ (Figure 3-A) and hydrogen peroxide (Figure 3-B) were determined to be 192.3 µM and 309.1 µM, respectively.

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PMC10940855

F, Heat map of differentially expressed genes in HAECs versus HDECs.

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PMC11539788

The results suggested that RNF19A expression was significantly decreased in BCa tissues compared to adjacent normal tissues (Fig. 1D-G), which was consistent with findings from the public databases.

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PMC9429973

One (2.8%) had mutations of NRAS and PTPN11, and 8 (22.2%) had no known JMML mutants.

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PMC7338939

Thus, in order to find a systematic method for determining the optimal amount of DAPT for every injection, the optimal control theory was applied.

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PMC9545474

Complexes 6–8 show significantly high cytotoxicity (nanomolar and low micromolar range) for the tested cell lines indicating that the presence of the triphenylphosphine moiety in the complexes is important for the cancer‐inhibiting properties of the compounds.

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