PMCID
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PMC9739791
BODIPY ligand with benzoic acid in meso-position was conjugated with oxoplatin by activation with TBTU (Figure 14).
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PMC9596868
The stock concentrations of both were divided into aliquots and stored at -20°C until use.
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PMC10671321
All these approaches point to pathophysiological mechanisms essentially characterized by a decrease in signaling and the presence of immature acetylcholine receptors.
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PMC11541409
42(3_suppl): p. 748-748.This reference is of outstanding importance because it reports that ripretinib has the similar effcicay with sunitinib as a second line therapy drug for GIST patients after imatinib failure.
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PMC9429973
We evaluated IE and spenomegaly by flow cytometry using CD71, Ter119 and CD44 analysis of bone marrow (BM) and and spleen (SPL).
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PMC10958426
Wilcoxon signed rank test were performed to examine whether the number of detected genes were significantly different between normal tissue and tumor tissue for endothelial cells and stromal cells. (
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PMC11740207
The earliest experimental evidence supporting the presence of malignancy stem cells (MSCs) in humans was reported in 1994 (Lapidot et al., 1994) and has since been the subject of extensive research, contributing to a better understanding of tumorigenesis and the development of more effective anti-malignancy therapies (...
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PMC11301242
Another contributing factor might be the rapid evolution of tumors driven by ecDNA, which results from rapidly acquiring high oncogene copy numbers .
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PMC6114978
Neither LATS1 nor LATS2 expression is increased in any (0%) of the cell lines after treatment with 5-azacytidine.
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PMC7759933
In HepG2 spheroids (Figure 5B), the basal mRNA level of UGT1A1 compared to monolayer culture showed great upregulation from day 3 onwards that was time-dependent, reaching a maximal level at day 12 (5.74-fold).
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PMC11694066
The synergy observed preclinically upon combination of PARPi and ATRi in the JN1 cell line (Fig. 2C) and GR_13 PDX-O model (Fig. 2F) also supports the latter approach.
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PMC11754432
Western analysis of EGFR normalised to loading control (B, N = 10).
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PMC11705862
The thickness of the Z-stack varies between 19.8 and 39.6 μm.
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PMC9429973
TEAEs occurred in all patients; however, no event of grade ≥ 3 occurred.
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PMC7342409
KIT expression in the GIST882 imatinib-resistant group was significantly higher than that in the GIST882 group (* p<0.05).
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PMC11453346
Hexose-6-phosphate dehydrogenase (H6PD) catalyzes the first two steps of the pentose-phosphate pathway in the endoplasmic reticulum (ER).
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PMC9429973
Within the hematopoietic system, HES6 has been described to be overexpressed in BPDCN, a very rare and aggressive hematological malignancy of plasmacytoid dendritic cells (pDCs).
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PMC9429973
The best response was SD (1/3 pts) and all pts progressed after completing 2 cycles.
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PMC11604015
CRISPR/Cas9, ZFN, and TALEN techniques edit genes through double-stranded DNA breakage, causing unpredictable genotoxicity on cells.
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PMC11367146
Hence, targeting a single molecule might not be enough to treat a disease effectively.
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PMC9429973
Pts reported that SCD caused a negative impact on emotions (28%), school achievement (19%), and a reduction in work hours (16%).
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PMC11462929
We next tried to confirm direct chromatin–chromatin interactions between BENC‐CNA and MYC.
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PMC9878278
It is likely that BMP6 suppression during the later stages of infection may be a virus-induced response to negatively impact the robustness of the interferon response, possibly another mechanism by which ZIKV antagonizes the IFN response.
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PMC9681981
Single bands with the sizes of 124 bp, 121 bp, and 170 bp are observed in the gel picture related to the cpa, etx, and 16S rRNA genes, respectively.
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PMC11763764
High-grade serous ovarian carcinoma is the most common type.
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PMC11060216
Lung cancer-related studies in recent years have suggested that the mechanism of S100A6 is complex, and may play different roles in different subtypes.
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PMC11721096
The synthesis of melanin was disrupted by using 1 M NaOH with 10% DMSO heating at 80 °C for 60 min.
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PMC10813895
Studies have indicated an age-related increase in 8-oxo-2′-deoxyguanosine (8-oxo-dG), an oxidized derivative of deoxyguanosine .
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PMC10747160
Wells were then blocked by gently dispensing 300 μL of Blocking Buffer.
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PMC7762347
On the other hand, MCLR alone had no influence on the expression of genes that respond to DNA damage, CDKN1A and GADD45A.
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PMC10878518
The ATM score of CAR expression was significantly higher in the malignant and intermediate group than in the benign group (P = 0.015) (Fig 3B).
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PMC11216402
RUNX and AP-1 (and lack of ZEB) were strong TFBS signals driving accessibility in Mes-like cell lines, whereas GRHL, GATA, and KLF TFBS were strongly associated with the most Epi-like samples (Fig. 1D,E).
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PMC11473750
p values were also adjusted using the Benjamini–Hochberg method to account for multiple comparisons.
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PMC11337594
The column was maintained at 40 °C, and each sample was injected with a volume of 2 µL. The mobile phase, consisting of 15 mM ammonium acetate and 3 mL/L ammonium hydroxide in LC‒MS grade water, as well as LC‒MS grade 90% acetonitrile–HPLC water, was run at a flow rate of 0.2 mL/min.
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PMC11731161
Further studies are still needed to explore the suppression spectrum of different inhibitors.
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PMC9429973
E. Krishnevskaya, M. Molero Magariño, Á. Ancochea Serra, J.-L. Vives Corrons, I. Hernandez, V. Leguizamón Red Blood Cell and Hematopoietic Disorders, Josep Carreras Leukaemia Research Institute (IJC); Haematology-Haemotherapy Service, Catalan Institute of Oncology.
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PMC10698968
The exchange of this information seems to be mainly carried out through vesicle trafficking instead of other membrane transport mechanisms.
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PMC9848491
For UCEC, the use of dostarlimab (anti-programmed cell death protein 1 antibody) alone or a tyrosine kinase inhibitor combined with pembrolizumab for advanced, metastatic, or recurrent endometrial cancer holds promise (3).
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PMC10723784
Data were presented as the mean ± SE of the mean.
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PMC9429973
In our study, CR rates were lower than the values reported in the literature (56-70%).
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PMC10329074
In terms of the results, lollipop data illustrations, group comparison charts and scatterplots were utilized to show visualized data.
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PMC11484188
Furthermore, downregulation of miRNAs in MM cell lines or patients suggests that increasing their expression might reduce the proliferation of MM cells in vitro, whereas decreasing their expression might enhance the proliferation of these cells, which including miR-34a, miR-137/197, miR-1271 and miR-125b (33-36).
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PMC9429973
Aims: To address characteristics and outcomes in a cohort of children with LO/LL diagnosed and followed by our Department.
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PMC10387886
In conclusion, we demonstrated that TGFβ1 activates ERK1/2 and p38 MAPK and induces in SKOV3 cells.
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PMC8540692
The intracellular detection of superoxide radicals was performed using The Muse Oxidative Stress Kit (Merck, Darmstadt, Germany), according to the manufacturer’s recommendations.
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PMC11754784
Leukocytes and plasma in the blood samples were removed by gradient centrifugation (800 × g) and erythrocytes were washed three times with DPBS.
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PMC10538569
Additionally, when DCs were added to TC : TC co-culture, transfer of GPI-scFv X5 from transduced CEMss cells to iDCs and subsequently from iDCs to naïve human primary CD4 T cells was not observed ( Figures S5A, B ).
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PMC9429973
The area under the curve was 0.79 (95% confidence interval: 0.74–0.84).
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PMC10936243
This is an interesting finding since from a veterinarian perspective OVH may be viewed as routine (Van Goethem et al. 2006) however for the cat in question the procedure is far from routine, i.e. the veterinary point of view may fail to take into account the cats’ perspective.
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PMC11742290
Cancer stem cells play an important role in tumor progression and chemotherapy resistance.
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PMC9429973
UBA.;
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PMC11637284
In short, because the overarching principle of kDNA segregation is “physically coupled co-segregation with basal bodies” , this necessitates a permanent OM-IM contact site formed by TAC60 and p166.
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PMC11317131
For example, Anzalone et al. demonstrated that delivery of pegRNA as RNA increases PE and integration rates, most likely due to preventing interactions between attP and attB sites on the pegRNA expression plasmids and the donor plasmid (22).
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PMC6650823
The authors found that prenatal administration to pregnant ferrets protected the fetuses against in utero development of CFTR defects and partially protected against the development of CF-related organ pathologies.
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PMC11665584
Next, every skin IFE keratinocyte was scored on the expression of the top 100 oral pseudotime-dependent genes, with a higher oral pseudotime gene expression score demonstrating higher expression of the set of oral genes (Figure 2D).
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PMC11739484
Drug sensitivity patterns were determined using Spearman’s correlation coefficient to assess the relationship between MMP expression and the response to various anticancer drugs.
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PMC10253973
This compound showed strong activity against cisplatin resistant cells—A2780cisR. Ruthplatin compounds 26–29 (Figure 9) are applied for treating tumor metastasis and drug resistance.
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PMC9966931
Some recent works have demonstrated the possibility of obtaining, by other chemical methods, a few of these hybrid molecules, namely, 2-Isopropyl-5-methylphenyl benzoate (1), 4-Allyl-2-methoxyphenyl benzoate (3), and 2-Isopropyl-5-methylphenyl cinnamate (4), and their potential bioactivity as antileishmanial and insect...
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PMC9792775
p < 0.05, **p < 0.01, ***p < 0.001, ns not significant.
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PMC10454535
Interestingly, BSO did not increase cytotoxic effects in the BTZ and PIN/BTZ groups, but did slightly decrease viability in the control and PIN groups (Figure 6d).
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PMC11617590
Indeed, SFN treatment induced the accumulation of β‐catenin.
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PMC8193046
InstantJChem (version 20.15.9) was applied to statistically analyze the initial dataset of 1,049 compounds for 308 commonly occurring chemical substructures and their distribution amongst classes 0–7. ‘
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PMC11638764
Cellular viability was determined after 48 hours.(B-D) Volcano plots comparing protein expression across different compartments relative to the DMSO control group are presented.
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PMC11314247
In all cases, 10,000 events were acquired.
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PMC11707832
These enzymes are primarily distributed across the endoplasmic reticulum, Golgi, lysosomes and cytoplasm.
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PMC10887351
Except for pathologic conditions, it has been largely demonstrated that β3-ARs have important physiological effects, such as lipolysis and thermogenesis regulation in adipocytes through the β-oxidation of fatty acids .
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PMC11670954
Following treatment, the cells were incubated for 24 h in the upper chambers.
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PMC10999934
Table 1DatasetsTypeChemoresistanceChemosensitivityTCGA-OVTissue60128GSE158937Tissue30GSE154600Tissue22GSE47856Cell line–– The key characteristics of the datasets in this study.
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PMC11599565
In addition, in the primary OC cells OC236, TH was primarily detected mainly in nested cells (Q) which also exhibited stronger Fontana-Masson staining (R).Fig.
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PMC11216402
TFBS PWM logos. (
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PMC11703992
B The cell viability of different groups of Jurkat cells, including DDIT4-KD/OE/Blank groups and the PMA induced/DDIT4-OE-PMA induced Jurkat cells.
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PMC8864075
siTWIST1 showed similar effects to reTFAE, and the synergistic application of reTFAE and siTWIST1 showed a more obvious effect on EMT-related protein expression (Figures 3F,G).
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PMC11792888
To investigate the type of cell death caused by R. junceus venom treatment, annexin V-FITC, and PI double-stained A549 and NCI-H460 cancer cells were analyzed with flow cytometry.
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PMC11593084
Since PMab-117 is an IgM mAb, comparing the reactivity to IgG mAbs, including NZ-1, is somewhat problematic.
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PMC11335267
Mean myofiber cross-sectional area (CSA) determined in gastrocnemius muscle from wild type or Alx3-deficient mice stained with hematoxylin and eosin (n = 5 wild type and 4 Alx3-deficient mice).
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PMC11515150
Body weight curve of each group at different days (n = 4; two-way ANOVA; *p < 0.05; n.s.,
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PMC11707577
We used an engineered M13 phage, genetically refactored to display on the phage tip a peptide (SYPIPDT) able to bind EGFR. ,
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PMC11769516
The STG and CPZ that are of interest to the authors are produced mainly by fungi of the Aspergillus spp.
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PMC11707577
A colocalization analysis using the FIJI Coloc 2 plugin showed a correlation, with a Pearson's R value equal to 0.66 for M13EGFR(TNP), as already observed for the nude M13EGFR phage.
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PMC11496728
In addition, three wells of each cell were screened with a DMEM/F12 complete medium containing Blasticidin to obtain a stable cell pool, which was suspended to detect stable expression.
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PMC11116779
At higher concentrations PS-NPs appear dispersed inside cellular endosomes (circular white areas), and cells start showing signs of toxicity.
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PMC11512230
At first, we studied the difference in the effectiveness of the adsorption of TMV SP, AltMV SPV, and AltMV SPVLP on three tumor lines and healthy cells.
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PMC9964635
Yield 76%, m.p 150–152 °C.
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PMC10808409
The relative expression was calculated based on 2 − ΔΔCt method and all data from three separate experiments are shown as mean ± SD. *
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PMC8073654
In the high-performance liquid chromatography/electrospray tandem mass spectroscopy (MS) analyses of phenylbutenoid dimers from Z. cassumunar by , two new structures were tentatively identified as trans-3-(3′,4′-dimethoxyphenyl)-4-[(E)-4′′′-hydroxy-3′′′-methoxystyryl]cyclohex-1-ene (39) and 3-(3′,4′-dimethoxyphenyl)-4-...
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PMC9429973
Groups had equal mean (53,4±21.2 mon in G1 vs 48,9±12.5 mon in G2, p=0.71) observation period and mean (48.0±11.7 yrs in G1 vs 48.9±12.5 yrs in G2, p=0.72) age.
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PMC11650848
A final discussion involves the action of FA on this region and its association with cognitive development in early life.
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PMC11483468
The cells were continuously cultured with PBS, T-GFP (TAT-GFP) or GST-TAT-LPTS39 for 3 to 6 weeks, then the cells (1–2 ×10/100 µL) were seeded on 96-well culture plates and treated with the corresponding protein or PBS solution.
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PMC11748363
Compound precipitated in the testing medium.
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PMC11711345
Determination of apoptosis/necrosis by flow cytometry analysis (Annexin V/propidium iodide) For apoptosis determination, Calu-3 cells were seeded (0.5 mL at 2×10 cells/mL) in a 24-well plate and incubated (24h) in 5% CO2 atmosphere at 37°C.
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PMC11721587
Hence, Fu maturation and Ci phosphorylation are both physically and temporarily coupled, suggesting that they occur in the same complex (Fig. 5G).
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PMC11803918
Representative images of confocal laser scanning microscopy (CLSM) examination of Ce6 uptake inside A375 cells with different formulations (scale bar: 20 μm). (
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PMC9429973
Only one pt definitely discontinued asciminib due to persistent anemia, but in the context of also a failing response.
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PMC11787355
f and g AC-like module score and frequency of distinct cellular states after ACT.
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PMC11247842
Various post-GWAS analyses were conducted to prioritize candidate genes and reveal the genetic architecture of mastitis in dairy cattle.
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PMC11592837
In PBMCs, we noticed a marked but statistically insignificant increase in the proportion of apoptotic cells from 4 h to 8 h of incubation with ETP, but not with DOX (Figure 4A).
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PMC11802929
Right: SCT cell capture efficiency for Pep-Groups.
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PMC3734024
Surface staining for CD9, CD93, CD21 and CD23 was neither higher nor lower than levels in FasL B cells.
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PMC7812570
The following reagents were obtained through the AIDS Reagent Program, Division of AIDS, NIAID, NIH: TZM-bl indicator cells, which stably express large amounts of CD4 and CCR5 and endogenously express CXCR4 (from John C. Kappes and Xiaoyun Wu); a panel of molecular clones for generating replication-competent HIV-1 isol...
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PMC11224020
Indeed, CK666 treatment of DCs confined at a height of 3 µm decreased the EFC ratio, indicating that the nuclear envelope of ARP2/3-inhibited DCs exhibits a more irregular shape than that in untreated confined DCs (Fig. 4c).
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