OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11568601	However, ER stress can be triggered under pathological conditions or upon microbial infection and is accompanied by increased CHOP expression and activated cell apoptosis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11306019	The mechanism behind these effects involves the interaction between the vicinal diol moieties of polyphenols and the boronic acid of BTZ, necessitating higher concentrations of polyphenols to counteract higher concentrations of BTZ.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11730311	Our findings demonstrate that lipidation can improve hαCGRP8-37 pharmacokinetics while maintaining hαCGRP antagonism, thus demonstrating potential for a peptide-based migraine treatment strategy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11279397	These findings suggest that phenolic compounds possess moderate affinity as ion channel modulators.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "suggest", "that", "phenolic", "compounds", "possess", ...
PMC9583612	For example, one site in basin B exhibited emissions between 51 and 1062 scfh, with a GHGRP-based inventory estimate of 295 scfh.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10975211	Derived from buforin II, Jang et al. designed several analogs named buforin III a-d.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Derived", "from", "buforin", "II", ",", "Jang", "et", ...
PMC11461874	The expression plasmid for TRIM25 (Flag-TRIM25/pcDNA3) is a kind gift from Dr. Shigetsugu Hatakeyama (Hokkaido University).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expression", "plasmid...
PMC11380454	Clinical studies are currently ongoing in other types of cancers, including hematological malignancies 1-5.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Clinical", "studies", "are", "currently", "ongoin...
PMC10587429	Comparison of the efficacy of CD47 blockade in non-humanized and humanized orthotopic mouse model of ES. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Comparison", "of", "the", "efficacy", "of", ...
PMC11194678	To further confirm the effect of STAU1 condensates in mRNA translation, we generated an RNA-binding-deficient STAU1 mutant based on the reported structure of STAU1 dsRBD3-4 in complex with ARF1 SBS (PDB ID: 6HTU) (Lazzaretti et al., 2018).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7039683	Roadmap Epigenomics Project cell lines (Visel et al., 2008): GM12878, B-cell derived cell line; ESC, Embryonic stem cells; K562, myelogenous leukemia; HepG2, liver cancer; HUVEC, Human umbilical vein endothelial cells; HMEC, human mammary epithelial cells; HSMM, human skeletal muscle myoblasts; NHEK, normal human epide...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLin...
PMC11513571	Enzyme-linked immunosorbent assay (ELISA) was used to measure TSLP levels in the sera of both MERS-CoV-infected (n=4; median age, 53 years) and healthy individuals (n=5; median age, 35 years).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11679892	Thus, in cases where gene expression was compared, the expression values of relevant genes in the control and dose groups were determined relatively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	54% had received an autologous stem cell transplant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "54", "%", "had", "received", "an", "autologous", "stem", "cell", "transplant", "." ] } ]
PMC11286266	The probes underwent in vivo biotinylation, purification using GFP-Trap Agarose (ChromoTek), and were eluted via TEV cleavage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "probes", "...
PMC11754784	a Identifying the rate-determining step in microenvironment-confined DNA computation by simulating the accelerated reaction rate in different computing layers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "a", "Identifying", "the", "rate-d...
PMC9429973	Summary/Conclusion: Understanding the mechanisms behind the tumor suppressive property of STAT3β has potential translational impact and is crucial to identify novel therapies and preventative strategies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	A high index of suspicion may help in early diagnosis and intervention in these patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "high", "index", "of", "suspicion", "may", "help", ...
PMC9341513	In a simulation of the U266 cells with the insert where we ‘switched off’ protein binding at four DHSs within the promoter and gene body of CCND1, there was a loss of CCND1 interactions compared to the previous U266 simulations (Supplemental Fig. S11C–E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11655536	A The cell viability of carfilzomib-resistant cell line ARH-77 R and parental cell line ARH-77 treated with carfilzomib for 48 h at the indicated concentration of carfilzomib.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC3122064	Acridine orange fluorescent staining of nuclei in unfixed cells was used to distinguish apoptotic from vital cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Acridine", "orange", "fluorescent", "staining", "...
PMC10873328	In this study, six hypoxia-related genes (TGFBI, AKAP12, CDKN1B, GPC1, TGM2 and ANGPTL4) were identified for their correlations with the prognosis of OC and four of them (TGFBI, AKAP12, GPC1 and TGM2) were chosen for prediction model of OC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Treatment with Alpelisib is well tolerated except for a mild increase in HbA1C levels to 6.7%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "with", "Alpelisib", "is", "well", ...
PMC6337547	These experimental results indicate that salvianolic acid B (1–100 μmol·L) significantly reduced the cell viability of U80 cells in a dose- and time-dependent manner.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: Unicentric retrospective analysis of HSCT recipients receiving GCV between 2007 and 2021.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "Unicentric", "retrospective", "analysis", "of", "HSCT"...
PMC6889484	A3G-D128K reconstitution was observed in 61 of the 69 cell clones, providing a reconstitution frequency of 89%, which was similar to the previously observed >87% deletion frequency for a 971-bp repeated sequence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Overall response rate for all pts and pts with ≥ 180 days of follow-up were 84% (95% CI 77-90%) [CR 71% (95% CI 63-79%)] and 78% (95% CI 67-87%) [CR 68% (95% CI 56-78%)], respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4112127	Combined treatment with the DNA methylation inhibitor 5-Aza-dC and the histone deacetylase inhibitor TSA restored BMP3 mRNA expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Combined", "treatment", "with", "the", ...
PMC10538569	In contrast, co-culture of CD4 T cells with CD8 T cells or GPI-scFv X5 transduced CD8 T cells resulted in a similar level of HIV-1 production, suggesting that expression of GPI-scFv X5 on CD8 T cells does not enhance control of HIV-1 in cocultures with CD4 T cells ( Figure 6B ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11732523	Furthermore, these patients are at a significantly elevated risk of developing long COVID-19 after recovery .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "these", "patients", "are", "at", ...
PMC9429973	Methods: We performed a retrospective analysis on 146 AML patients (aged 21-65) who were diagnosed and treated with intensive chemotherapy between 2017-2020.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10253553	Relative mRNA levels were quantified and normalized to GAPDH or β-actin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Relative", "mRNA", "levels", "were", "quantified", "and", "normalized", "to", "GAPDH", ...
PMC11549612	Future studies should incorporate in vivo models, such as patient-derived xenografts or organoid models, to better understand how BOLA gene silencing affects tumor growth and behavior in a more physiologically relevant setting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	All 16 of these patients responded during the survey that they wished to know their leukemia diagnosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "16", "of", "these", "patients", "res...
PMC11787355	Encouraging results have been demonstrated in Phase I and II clinical trials using TCR-engineered T cells (TCR-T) to treat solid tumors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Encoura...
PMC11502443	This suggests greater induction of Gαq coupling and signaling at the E354Q variant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "suggests", "greater", "induction", "of", "Gαq", "coupling", "and", ...
PMC11686380	Next, since GAP43 plays a pivotal role in axon pathfinding, we examined the effects of GAP43 knockdown on axon elongation into the contralateral hemisphere.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11730320	First, we considered substitutions and small insertion/deletion (indel) variants that were rare (frequency <5% based on gnomAD v2.1.1) and that impacted exonic sequence directly, or that could impact it indirectly by altering splicing or other regulatory sequences.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11761919	On day 3 post-infection (dpi), autopsies were performed to observe gross pathological lesions livers, hearts, spleens, and kidneys, then fixed for histopathological examination.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	31.7% (20/63) of patients had B symptoms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "31.7", "%", "(", "20/63", ")", "of", "patients", "had", "B", "symptoms", "." ] } ]
PMC6379402	For KP and GO-BP annotations, we only present averages over all eight tissues in the main paper and give details in Supplementary Figs. 2 and 3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7081114	The fixed cells were washed with PBS, stained with Crystal Violet Staining Solution (Shanghai Yuanye Bio-Technology Co., Ltd. Shanghai, China) for 10–20 min, and washed several times with double-distilled water.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7724160	The separation was isocratic and performed using a flow rate of 0.5 mL/minute for 30 min at room temperature (Buffer: PBS at pH 7.2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10170482	Immunofluorescence staining was performed on fixed cells using the anti-Ki67 antibody followed by the Alexa Fluor 568-conjugated secondary antibody (Thermo Fisher Scientific, Waltham, MA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11155445	The mode of action of these acyl thioureas was explained based on molecule targeting the RNA-dependent RNA polymerase to inhibit the proliferation of influenza viruses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Limited by small sample size, correlation analysis wasn’t done Image: Summary/Conclusion: Our study demonstrates bispecific CS1-BCMA CAR-T cells are clinical active with a good safety profile in heavily pretreated patients with MM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11640476	FI was measured using the EnSpire Multimode Plate Reader (Perkin Elmer, Waltham, MA, USA) at 12 λEx-λEm combinations, joining 4 λEx (530, 535, 540, and 545 nm) with 3 λEm (585, 590, and 595 nm) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11588008	Informed consent: Informed consent has been obtained from all individuals included in this study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Informed", "consent", ":", "Informed", "consent", "has", "b...
PMC6182045	Size exclusion chromatography (SEC) was used to further purify protein products from Affinity and QFF methods (A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Size", "exclusion", ...
PMC11128598	Ethical approval was not required for the studies on animals in accordance with the local legislation and institutional requirements because only commercially available established cell lines were used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8382973	All experimental data are expressed as the mean ± standard deviation (Mean ± SD).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "experimental", "data", "are", "expressed", "as"...
PMC10890307	MRC-5, A427, SKMES-1, and MCF-7 consumed lactate during the exponential growth phase (Table 4, Figure 2 and Figure 3).	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11240448	Gene mutations and other genetic aberrations embedded in individual protein expression landscapes drive pathological BC phenotypes through deregulated input–output behaviors of complex molecular networks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10506676	Also, the presence of EBNA1 induced the expression of BIRC5 and c-MYC, which increased tenfold (P=0.03) and threefold (P=0.02), respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11473750	This exquisite vulnerability of the MYCN oncogenic signal indicates that inhibitors of RNF121 effects on MYCN may have potent therapeutic benefits in patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", ...
PMC9429973	Z. Xu, M. Duan, Q. Jiang, Q. Leng, N. Xu, Y. Zhang, C. Zhao, W. Wu, Q. Zhang, J. Fu, J. Zhang, R. Fu, Z. Yan, J. Zhang, C. Lin, G. Ouyang, Z. Wang, L. Ma, H. Hao, X. Li, S. Ran, Y. Chen, T. Li, Z. Xiao State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of He...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11700340	Although chemotherapy treatment can improve survival, its side effects still pose a major challenge for specific patients, specifically those with chronic disease, old age, and immunocompromised patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3765139	The frequency of proliferating cells was evaluated by Poisson’s distribution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "frequency", "of", "proliferating", "cells", "was", "evaluated", "by", "Poisson", ...
PMC8427838	Whole cell lysates (WCL) from the same group were blotted for total Moesin or GAPDH.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Whole", "cell", "lysates", "(", "WCL", ")",...
PMC11634027	Scale bar: 100 µm. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ":", "100", "µm", ".", "(" ] } ]
PMC11087766	To determine the identity of the factors that facilitate protein trafficking into the phage nucleus, we designed a genetic selection to isolate mutant phage that no longer import a toxic protein, a similar method as that which was used to initially identify many of the protein secretion genes in Escherichia coli (37).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11650848	Significant p value: p < 0.05 tested via ANOVA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Significant", "p", "value", ":", "p", "<", "0.05", "tested", "via", "ANOVA", "." ] }...
PMC11519583	To this end, we examined whether Wnt5b can bind to Ror2 in Cos7 cells ectopically expressing Ror2 (wild-type) or Ror2 (ΔCRD) lacking the cysteine-rich domain (CRD), a putative Wnt protein-binding site, along with Wnt5b.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10582049	The stratification strategy was based on the calculation of the Score Indicative of Lung Cancer Aggression (SILA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "stratification", "strategy", ...
PMC9065483	Cells were scraped and the collected lysate was centrifuged.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "scraped", "and", "the", "collected", "lysate", "was", "centrifuged", "." ] } ]
PMC11224020	DC confinement at a height of 4 μm was thus chosen as the negative-control condition for all following experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DC", "confinement", "at", "a", ...
PMC8956657	MERS ORF4b nuclear translocation: Huh7 cells (3 × 10) grown on glass coverslips were transfected with indicated wt and mutant Flag-tagged MERS ORF4b plasmids (500 ng) using Lipofectamine 2000 (Thermo Fisher Scientific, MA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10329074	Kaplan Meier analysis was performed to assess the correlation between YBX3 and the survival rate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Kaplan", "Meier", "analysis", "was", "performed", "to", "as...
PMC11271278	The coverslips were sealed with rubber cement and denatured in a heated incubator at 82 °C for 1 min, followed by incubation in a humidified chamber at 37 °C overnight.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10114490	F HCS analysis of amiodarone incubation at 1–10-100–1000 µM in PD and PD diHLC-T (six replicates each). *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "F", "HCS", ...
PMC10933092	IGV visualization analysis was simultaneously used to visually present the sequencing results, which revealed a discernible reduction in the overall level of mA modification peaks following TRMT61A knockdown (Figure 3C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11585587	MMP change is an early marker of apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MMP", "change", "is", "an", "early", "marker", "of", "apoptosis", "." ] } ]
PMC11489175	DUB enzymes can be grouped in two major classes: cysteine proteases (CP) and metallo proteases (MP) (Figure 1) 18,19.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9577200	The zeta potential for GO was negative at all pH values.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "zeta", "potential", "for", "GO", "was", "negative", "at", "all", "pH", "...
PMC10154881	The importance of CD8 T cells in oncolytic virotherapy has already been reported for Zika virus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "importance", "of", "CD8", "T", "cells", "...
PMC11506827	Ginseng-derived GEF exhibits diverse biological effects, including anti-inflammatory and anticancer properties .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ginseng-derived", "GEF", "exhibits", "diverse", "biological", "effects", ",", "includi...
PMC11755519	Exosomes secreted by T24 and J82 cells significantly increased the viability of TSGH-8301 cells, especially J82 exosomes, which showed a stronger effect after 24 h of treatment.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", ...
PMC11592008	In PKs and HaSKpw cells, the ELISA revealed a significant and strong increase in secreted IL-1β levels upon UVB irradiation (Figure 2E).	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ],...
PMC11767817	5637 cells were seeded in a 24-well plate at a density of 0.1 × 10 cells per well.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "5637", "cells", "were", "seeded", ...
PMC11470381	Images should be carefully monitored for any evidence of photobleaching and consequent loss of signal during the course of live-cell imaging.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Images", "should", ...
PMC11680578	PPAR-γ is a highly conserved nuclear receptor expressed throughout the bodyand shown to play a critical role in cell differentiation, apoptosis, angiogenesis, and epithelial-mesenchymal transition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7433824	Despite the P4 receptor is a steroid receptor that has the highest correlation with glial tumor grade , ; there exist surprisingly few studies which assessed the effects of P4 on the biological behavior of GBMs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806818	Due to the large specific surface area, high stability, unique biocompatibility, and peroxidase mimetic activity of Mn3O4 and Pd@Pt floral nanoenzymes, nanoprobe 1 is able to amplify biosensor signals by catalyzing the oxidation of hydroquinone (HQ) by H2O2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7723249	Interestingly, in contrast to HAZV, PMA followed by EGTA treatment increases CCHFV infection apically compared to only PMA treatment (Fig 2B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11731614	Workflow schematic for KDEV isolation using size-exclusion chromatography.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Workflow", "schematic", "for", "KDEV", "isolation", "using", "size-exclusion", "chromatography", "." ] } ]
PMC11395280	T-ALL cells migrated in the presence of CCL19, which indicates that β1 integrins can promote migration across a polycarbonate membrane in response to stimulation with CCL19.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9436459	Among them, the plant of M. alba has the largest number MDAAs, more than 70, covering eight types including Types A − F, H, and I. M. mongolica contains 45 MDAAs also involving in all eight types except for Type G. 38 and 16 MDAAs were isolated from M. macroura and M. bombycis, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11644761	This indicates that pterostilbene did not alter the differentiated status of the cells, as further supported by the observed decrease in cyclin CCND1 expression (Figure 1B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11271278	Raw FASTQ files were aligned to hg19 using BWA-MEM and the aligned reads were sorted and indexed with Samtools.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Raw", "FASTQ", "files", "were", ...
PMC11725127	HEK293T cells stably expressing Flag-KRAS were co-transfected with an increasing dose of Myc-USP2.	[ { "tags": [ "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HEK293", "T", "cells", "stably", "expressing", "Flag-KRAS"...
PMC9454178	B, C qRT–PCR and immunoblotting analyses showed that OSR1 expression was inhibited by CDK7 knockdown or THZ1 treatment in a dose-dependent manner.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC7452526	Zeta potential measurements were carried out by injecting 1mL of the sample into the zeta cell.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Zeta", "potential", "measurements", "were", "carried", ...
PMC11495567	It involves the binding of FITC-conjugated Annexin to externalized phosphatidylserine of apoptotic cells and propidium iodide (PI) binding to the nucleic acids of necrotic cells with compromised cell membranes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10758402	Herpes simplex virus gamma 47 delta (HSV-G47Δ) has deletions in the g34.5 and a47 genes, and the inactivating insertion of LacZ into ICP6 was obtained as a generous gift from Dr. Samuel Rabkin of Harvard University.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	One responded to second-line treatment with Mychofenolate-mofetil (MMF) and periodic infusion of immunoglobulins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "responded", "to", "second-line", "treatment", "with", ...
PMC3274243	For a comparative study, the same cell line and camptothecin concentrations were examined by the conventional MTT assay after 24 h (Figure 5b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10507284	KM analysis of PFI for high (n = 252) and low (n = 60) TROAP expression groups in the GSE71118 dataset.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Aims: We have investigated the expression level pattern of lncRNA GAS5 in younger AML patients and examined its potential influence on disease outcome.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11792090	Anti-CD70 UCAR-T cells were then generated by knocking out TRAC, B2M, and HLA-DRA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Anti-CD70", "UCAR-T", "cells", "were", "then", "genera...
PMC4839679	Protein levels of BRG1 and PBRM1 in ccRCC cell lines. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Protein", "levels", "of", "BRG1", "and", "PBRM1", "in", "ccRCC", "cell", "lines", ...

PMC11568601

However, ER stress can be triggered under pathological conditions or upon microbial infection and is accompanied by increased CHOP expression and activated cell apoptosis .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11306019

The mechanism behind these effects involves the interaction between the vicinal diol moieties of polyphenols and the boronic acid of BTZ, necessitating higher concentrations of polyphenols to counteract higher concentrations of BTZ.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11730311

Our findings demonstrate that lipidation can improve hαCGRP8-37 pharmacokinetics while maintaining hαCGRP antagonism, thus demonstrating potential for a peptide-based migraine treatment strategy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11279397

These findings suggest that phenolic compounds possess moderate affinity as ion channel modulators.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "suggest", "that", "phenolic", "compounds", "possess", ...

PMC9583612

For example, one site in basin B exhibited emissions between 51 and 1062 scfh, with a GHGRP-based inventory estimate of 295 scfh.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC10975211

Derived from buforin II, Jang et al. designed several analogs named buforin III a-d.

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PMC11461874

The expression plasmid for TRIM25 (Flag-TRIM25/pcDNA3) is a kind gift from Dr. Shigetsugu Hatakeyama (Hokkaido University).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expression", "plasmid...

PMC11380454

Clinical studies are currently ongoing in other types of cancers, including hematological malignancies 1-5.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Clinical", "studies", "are", "currently", "ongoin...

PMC10587429

Comparison of the efficacy of CD47 blockade in non-humanized and humanized orthotopic mouse model of ES. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Comparison", "of", "the", "efficacy", "of", ...

PMC11194678

To further confirm the effect of STAU1 condensates in mRNA translation, we generated an RNA-binding-deficient STAU1 mutant based on the reported structure of STAU1 dsRBD3-4 in complex with ARF1 SBS (PDB ID: 6HTU) (Lazzaretti et al., 2018).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7039683

Roadmap Epigenomics Project cell lines (Visel et al., 2008): GM12878, B-cell derived cell line; ESC, Embryonic stem cells; K562, myelogenous leukemia; HepG2, liver cancer; HUVEC, Human umbilical vein endothelial cells; HMEC, human mammary epithelial cells; HSMM, human skeletal muscle myoblasts; NHEK, normal human epide...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLin...

PMC11513571

Enzyme-linked immunosorbent assay (ELISA) was used to measure TSLP levels in the sera of both MERS-CoV-infected (n=4; median age, 53 years) and healthy individuals (n=5; median age, 35 years).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11679892

Thus, in cases where gene expression was compared, the expression values of relevant genes in the control and dose groups were determined relatively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC9429973

54% had received an autologous stem cell transplant.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "54", "%", "had", "received", "an", "autologous", "stem", "cell", "transplant", "." ] } ]

PMC11286266

The probes underwent in vivo biotinylation, purification using GFP-Trap Agarose (ChromoTek), and were eluted via TEV cleavage.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "probes", "...

PMC11754784

a Identifying the rate-determining step in microenvironment-confined DNA computation by simulating the accelerated reaction rate in different computing layers.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "a", "Identifying", "the", "rate-d...

PMC9429973

Summary/Conclusion: Understanding the mechanisms behind the tumor suppressive property of STAT3β has potential translational impact and is crucial to identify novel therapies and preventative strategies.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC9429973

A high index of suspicion may help in early diagnosis and intervention in these patients.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "high", "index", "of", "suspicion", "may", "help", ...

PMC9341513

In a simulation of the U266 cells with the insert where we ‘switched off’ protein binding at four DHSs within the promoter and gene body of CCND1, there was a loss of CCND1 interactions compared to the previous U266 simulations (Supplemental Fig. S11C–E).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11655536

A The cell viability of carfilzomib-resistant cell line ARH-77 R and parental cell line ARH-77 treated with carfilzomib for 48 h at the indicated concentration of carfilzomib.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...

PMC3122064

Acridine orange fluorescent staining of nuclei in unfixed cells was used to distinguish apoptotic from vital cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Acridine", "orange", "fluorescent", "staining", "...

PMC10873328

In this study, six hypoxia-related genes (TGFBI, AKAP12, CDKN1B, GPC1, TGM2 and ANGPTL4) were identified for their correlations with the prognosis of OC and four of them (TGFBI, AKAP12, GPC1 and TGM2) were chosen for prediction model of OC.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Treatment with Alpelisib is well tolerated except for a mild increase in HbA1C levels to 6.7%.

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PMC6337547

These experimental results indicate that salvianolic acid B (1–100 μmol·L) significantly reduced the cell viability of U80 cells in a dose- and time-dependent manner.

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PMC9429973

Methods: Unicentric retrospective analysis of HSCT recipients receiving GCV between 2007 and 2021.

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PMC6889484

A3G-D128K reconstitution was observed in 61 of the 69 cell clones, providing a reconstitution frequency of 89%, which was similar to the previously observed >87% deletion frequency for a 971-bp repeated sequence.

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PMC9429973

Overall response rate for all pts and pts with ≥ 180 days of follow-up were 84% (95% CI 77-90%) [CR 71% (95% CI 63-79%)] and 78% (95% CI 67-87%) [CR 68% (95% CI 56-78%)], respectively.

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PMC4112127

Combined treatment with the DNA methylation inhibitor 5-Aza-dC and the histone deacetylase inhibitor TSA restored BMP3 mRNA expression.

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PMC10538569

In contrast, co-culture of CD4 T cells with CD8 T cells or GPI-scFv X5 transduced CD8 T cells resulted in a similar level of HIV-1 production, suggesting that expression of GPI-scFv X5 on CD8 T cells does not enhance control of HIV-1 in cocultures with CD4 T cells ( Figure 6B ).

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PMC11732523

Furthermore, these patients are at a significantly elevated risk of developing long COVID-19 after recovery .

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PMC9429973

Methods: We performed a retrospective analysis on 146 AML patients (aged 21-65) who were diagnosed and treated with intensive chemotherapy between 2017-2020.

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PMC10253553

Relative mRNA levels were quantified and normalized to GAPDH or β-actin.

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PMC11549612

Future studies should incorporate in vivo models, such as patient-derived xenografts or organoid models, to better understand how BOLA gene silencing affects tumor growth and behavior in a more physiologically relevant setting.

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PMC9429973

All 16 of these patients responded during the survey that they wished to know their leukemia diagnosis.

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PMC11787355

Encouraging results have been demonstrated in Phase I and II clinical trials using TCR-engineered T cells (TCR-T) to treat solid tumors.

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PMC11502443

This suggests greater induction of Gαq coupling and signaling at the E354Q variant.

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PMC11686380

Next, since GAP43 plays a pivotal role in axon pathfinding, we examined the effects of GAP43 knockdown on axon elongation into the contralateral hemisphere.

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PMC11730320

First, we considered substitutions and small insertion/deletion (indel) variants that were rare (frequency <5% based on gnomAD v2.1.1) and that impacted exonic sequence directly, or that could impact it indirectly by altering splicing or other regulatory sequences.

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PMC11761919

On day 3 post-infection (dpi), autopsies were performed to observe gross pathological lesions livers, hearts, spleens, and kidneys, then fixed for histopathological examination.

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PMC9429973

31.7% (20/63) of patients had B symptoms.

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PMC6379402

For KP and GO-BP annotations, we only present averages over all eight tissues in the main paper and give details in Supplementary Figs. 2 and 3.

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PMC7081114

The fixed cells were washed with PBS, stained with Crystal Violet Staining Solution (Shanghai Yuanye Bio-Technology Co., Ltd. Shanghai, China) for 10–20 min, and washed several times with double-distilled water.

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PMC7724160

The separation was isocratic and performed using a flow rate of 0.5 mL/minute for 30 min at room temperature (Buffer: PBS at pH 7.2).

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PMC10170482

Immunofluorescence staining was performed on fixed cells using the anti-Ki67 antibody followed by the Alexa Fluor 568-conjugated secondary antibody (Thermo Fisher Scientific, Waltham, MA, USA).

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PMC11155445

The mode of action of these acyl thioureas was explained based on molecule targeting the RNA-dependent RNA polymerase to inhibit the proliferation of influenza viruses.

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PMC9429973

Limited by small sample size, correlation analysis wasn’t done Image: Summary/Conclusion: Our study demonstrates bispecific CS1-BCMA CAR-T cells are clinical active with a good safety profile in heavily pretreated patients with MM.

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PMC11640476

FI was measured using the EnSpire Multimode Plate Reader (Perkin Elmer, Waltham, MA, USA) at 12 λEx-λEm combinations, joining 4 λEx (530, 535, 540, and 545 nm) with 3 λEm (585, 590, and 595 nm) .

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PMC11588008

Informed consent: Informed consent has been obtained from all individuals included in this study.

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PMC6182045

Size exclusion chromatography (SEC) was used to further purify protein products from Affinity and QFF methods (A).

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PMC11128598

Ethical approval was not required for the studies on animals in accordance with the local legislation and institutional requirements because only commercially available established cell lines were used.

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PMC8382973

All experimental data are expressed as the mean ± standard deviation (Mean ± SD).

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PMC10890307

MRC-5, A427, SKMES-1, and MCF-7 consumed lactate during the exponential growth phase (Table 4, Figure 2 and Figure 3).

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PMC11240448

Gene mutations and other genetic aberrations embedded in individual protein expression landscapes drive pathological BC phenotypes through deregulated input–output behaviors of complex molecular networks.

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PMC10506676

Also, the presence of EBNA1 induced the expression of BIRC5 and c-MYC, which increased tenfold (P=0.03) and threefold (P=0.02), respectively.

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PMC11473750

This exquisite vulnerability of the MYCN oncogenic signal indicates that inhibitors of RNF121 effects on MYCN may have potent therapeutic benefits in patients.

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PMC9429973

Z. Xu, M. Duan, Q. Jiang, Q. Leng, N. Xu, Y. Zhang, C. Zhao, W. Wu, Q. Zhang, J. Fu, J. Zhang, R. Fu, Z. Yan, J. Zhang, C. Lin, G. Ouyang, Z. Wang, L. Ma, H. Hao, X. Li, S. Ran, Y. Chen, T. Li, Z. Xiao State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of He...

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PMC11700340

Although chemotherapy treatment can improve survival, its side effects still pose a major challenge for specific patients, specifically those with chronic disease, old age, and immunocompromised patients.

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PMC3765139

The frequency of proliferating cells was evaluated by Poisson’s distribution.

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PMC8427838

Whole cell lysates (WCL) from the same group were blotted for total Moesin or GAPDH.

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PMC11634027

Scale bar: 100 µm. (

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PMC11087766

To determine the identity of the factors that facilitate protein trafficking into the phage nucleus, we designed a genetic selection to isolate mutant phage that no longer import a toxic protein, a similar method as that which was used to initially identify many of the protein secretion genes in Escherichia coli (37).

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PMC11650848

Significant p value: p < 0.05 tested via ANOVA.

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PMC11519583

To this end, we examined whether Wnt5b can bind to Ror2 in Cos7 cells ectopically expressing Ror2 (wild-type) or Ror2 (ΔCRD) lacking the cysteine-rich domain (CRD), a putative Wnt protein-binding site, along with Wnt5b.

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PMC10582049

The stratification strategy was based on the calculation of the Score Indicative of Lung Cancer Aggression (SILA).

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PMC9065483

Cells were scraped and the collected lysate was centrifuged.

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PMC11224020

DC confinement at a height of 4 μm was thus chosen as the negative-control condition for all following experiments.

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PMC8956657

MERS ORF4b nuclear translocation: Huh7 cells (3 × 10) grown on glass coverslips were transfected with indicated wt and mutant Flag-tagged MERS ORF4b plasmids (500 ng) using Lipofectamine 2000 (Thermo Fisher Scientific, MA).

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PMC10329074

Kaplan Meier analysis was performed to assess the correlation between YBX3 and the survival rate.

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PMC11271278

The coverslips were sealed with rubber cement and denatured in a heated incubator at 82 °C for 1 min, followed by incubation in a humidified chamber at 37 °C overnight.

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PMC10114490

F HCS analysis of amiodarone incubation at 1–10-100–1000 µM in PD and PD diHLC-T (six replicates each). *

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PMC10933092

IGV visualization analysis was simultaneously used to visually present the sequencing results, which revealed a discernible reduction in the overall level of mA modification peaks following TRMT61A knockdown (Figure 3C).

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PMC11585587

MMP change is an early marker of apoptosis.

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PMC11489175

DUB enzymes can be grouped in two major classes: cysteine proteases (CP) and metallo proteases (MP) (Figure 1) 18,19.

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PMC9577200

The zeta potential for GO was negative at all pH values.

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PMC10154881

The importance of CD8 T cells in oncolytic virotherapy has already been reported for Zika virus.

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PMC11506827

Ginseng-derived GEF exhibits diverse biological effects, including anti-inflammatory and anticancer properties .

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PMC11755519

Exosomes secreted by T24 and J82 cells significantly increased the viability of TSGH-8301 cells, especially J82 exosomes, which showed a stronger effect after 24 h of treatment.

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PMC11592008

In PKs and HaSKpw cells, the ELISA revealed a significant and strong increase in secreted IL-1β levels upon UVB irradiation (Figure 2E).

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PMC11767817

5637 cells were seeded in a 24-well plate at a density of 0.1 × 10 cells per well.

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PMC11470381

Images should be carefully monitored for any evidence of photobleaching and consequent loss of signal during the course of live-cell imaging.

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PMC11680578

PPAR-γ is a highly conserved nuclear receptor expressed throughout the bodyand shown to play a critical role in cell differentiation, apoptosis, angiogenesis, and epithelial-mesenchymal transition.

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PMC7433824

Despite the P4 receptor is a steroid receptor that has the highest correlation with glial tumor grade , ; there exist surprisingly few studies which assessed the effects of P4 on the biological behavior of GBMs.

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PMC11806818

Due to the large specific surface area, high stability, unique biocompatibility, and peroxidase mimetic activity of Mn3O4 and Pd@Pt floral nanoenzymes, nanoprobe 1 is able to amplify biosensor signals by catalyzing the oxidation of hydroquinone (HQ) by H2O2.

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PMC7723249

Interestingly, in contrast to HAZV, PMA followed by EGTA treatment increases CCHFV infection apically compared to only PMA treatment (Fig 2B).

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PMC11731614

Workflow schematic for KDEV isolation using size-exclusion chromatography.

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PMC11395280

T-ALL cells migrated in the presence of CCL19, which indicates that β1 integrins can promote migration across a polycarbonate membrane in response to stimulation with CCL19.

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PMC9436459

Among them, the plant of M. alba has the largest number MDAAs, more than 70, covering eight types including Types A − F, H, and I. M. mongolica contains 45 MDAAs also involving in all eight types except for Type G. 38 and 16 MDAAs were isolated from M. macroura and M. bombycis, respectively.

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PMC11644761

This indicates that pterostilbene did not alter the differentiated status of the cells, as further supported by the observed decrease in cyclin CCND1 expression (Figure 1B).

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PMC11271278

Raw FASTQ files were aligned to hg19 using BWA-MEM and the aligned reads were sorted and indexed with Samtools.

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PMC11725127

HEK293T cells stably expressing Flag-KRAS were co-transfected with an increasing dose of Myc-USP2.

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PMC9454178

B, C qRT–PCR and immunoblotting analyses showed that OSR1 expression was inhibited by CDK7 knockdown or THZ1 treatment in a dose-dependent manner.

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PMC7452526

Zeta potential measurements were carried out by injecting 1mL of the sample into the zeta cell.

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PMC11495567

It involves the binding of FITC-conjugated Annexin to externalized phosphatidylserine of apoptotic cells and propidium iodide (PI) binding to the nucleic acids of necrotic cells with compromised cell membranes.

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PMC10758402

Herpes simplex virus gamma 47 delta (HSV-G47Δ) has deletions in the g34.5 and a47 genes, and the inactivating insertion of LacZ into ICP6 was obtained as a generous gift from Dr. Samuel Rabkin of Harvard University.

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PMC9429973

One responded to second-line treatment with Mychofenolate-mofetil (MMF) and periodic infusion of immunoglobulins.

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PMC3274243

For a comparative study, the same cell line and camptothecin concentrations were examined by the conventional MTT assay after 24 h (Figure 5b).

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PMC10507284

KM analysis of PFI for high (n = 252) and low (n = 60) TROAP expression groups in the GSE71118 dataset.

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PMC9429973

Aims: We have investigated the expression level pattern of lncRNA GAS5 in younger AML patients and examined its potential influence on disease outcome.

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PMC11792090

Anti-CD70 UCAR-T cells were then generated by knocking out TRAC, B2M, and HLA-DRA.

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PMC4839679

Protein levels of BRG1 and PBRM1 in ccRCC cell lines. (

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