OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11420784	Urinary tract infections (UTIs), affecting 150 million people each year globally, are one of the most common bacterial infections .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Urinary...
PMC11740399	The cells were then trypsinized to detach from the culture plates, collected by centrifugation, and resuspended in cold PBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "w...
PMC10507284	TROAP knockdown efficiency of siRNA in the SW982 cell line was detected by western blot.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TROAP", "knockdown", "efficiency", "of", "siRNA", "in", ...
PMC10560648	A comparison of changes in cell viability showed that the normal lymphocyte cells were able to regenerate 100% of their killed cells during the three times exposed to the venom compared to the survival of the first treatment (24 hours), While the Jurkat cell line was unable to regenerate killed cells during three expos...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11247842	Functional consequences of variants were annotated by VEP with cache files (version 104) for combined annotation of Ensembl and Refseq transcripts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Functio...
PMC11725127	While small-molecule KRAS inhibitors show promise, they are less effective against other KRAS mutations, such as the G12D mutation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "small-molecule...
PMC9672323	Significant changes are indicated with asterisk (p < 0.05, p < 0.01, p < 0.001, **p < 0.0001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11756514	Naturally occurring amino acid polymorphisms of langerin can influence the glycan specificity, e.g., it may confer an increased GlcNAc preference as compared to the preference for mannose residues of the WT langerin (63).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11585994	Although there was no significant difference in survival between the G5-sgc8-siBCL11B and G5-siBCL11B groups, a trend towards improved survival was observed (p = 0.0993).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Subcutaneous (SC) delivery of antibody therapies has been shown to be effective and well tolerated and offers several advantages over IV administration in regards to improved healthcare utilization, including ease of administration, reduced treatment burden and reduced hospitalization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11301242	Changes in ecDNA gene expression levels before and after treatment in the same circular sample.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Changes", "in", "ecDNA", "gene", "expression", "levels", "b...
PMC11194678	Representative images showing protein concentration-dependent LLPS of STAU1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "images", "showing", "protein", "concentration-dependent", "LLPS", "of", "STAU1", "." ] } ]
PMC4659567	The spectra of 8 recorded on 10% MeOD-d 4/D2O solutions contained only the signals of the p-cymene hydrogens, represented by two pairs of C13,15–H2/C12,16–H2 signals at 5.98/5.74 and 5.38/5.17 ppm (an integral intensity ratio of 1: 1) (Fig 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11765988	Diffusion measurements also revealed lower values in sarcoidosis-affected nodes than those with malignant lymphoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Diffusion", "measurements", "also", "revealed", "lower", "values", "in...
PMC11594588	It also leads to nitric oxide synthase (NOS) induction and therefore to NO synthesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "also", "leads", "to", "nitric", "oxide", "...
PMC11367146	These results confirm that VTE can downregulate the expression of multiple inflammatory mediators.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "confirm", "that", "VTE", "can", "downregulate", "the", ...
PMC11474209	These include sewage, metals, nanomaterials (NMs), personal care products (PPCPs), pharmaceuticals, and persistent organic pollutants (POPs), which discharge into water, contaminate, create a stressful environment, and lead to water pollution .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11593084	We used GraphPad PRISM 6 software for the calculation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "used", "GraphPad", "PRISM", "6", "software", "for", "the", "calculation", "." ] } ]
PMC11532793	We found that the accuracy of the DTE results was not very sensitive to the number of Gibbs or bootstrap samples generated, and that fewer technical replicates are required for good accuracy than is usual for either Salmon or kallisto.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	All 25 responding pts underwent consolidation, except one that proceeded directly to allogenic stem cell transplantation (HSCT).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "25", "responding", ...
PMC9250505	Scale bars, 50 µm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", ",", "50", "µm", "." ] } ]
PMC11052306	This compound, 1-G0, was found to be more toxic than cisplatin against leukemia cells (MOLT-4) and breast cancer cells (MCF-7, cisplatin-resistant cell line) but is also very toxic against the benign Chang Liver cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "...
PMC9429973	Results: A total of 2,541 records were screened at title/abstract, 441 at full-text and 7 references were identified through other sources.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results...
PMC11046454	To further assess the therapeutic efficacy of these treatments, the mice were sacrificed on day 42.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "further", "assess", "the", "therapeutic", ...
PMC10530622	Relations between a dysbiotic gut microbiota and disease have been established in different physiologic systems, including the gut–kidney axis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Relations", ...
PMC9847912	We found that an MOI of 9.0 × 10 TCID50 per cell produced MAGIC-5A–detectable titers for nearly all of the viruses that were tested in the spreading infection assay (Table 1), while at the same time avoiding excessive CPE in the CEMss cultures (i.e., ≤40% of cells involved in syncytia).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787381	Interestingly, both β2-AR and BuChE are promising and complementary targets for treating AD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "both", "β2-AR", "and", "BuChE", "are", "pr...
PMC8777939	Etravirine was administered at the indicated concentrations every two days for seven days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Etravirine", "was", "administered", "at", "the", "indicated", "concentrations", ...
PMC11597167	Fluorescence resonance energy transfer (FRET) technology was used to measure the enzymatic activity of BACE1, and measurements were performed by modifying previously used methods and the protocol included in the manufacturer’s (PanVera Corporation, Madison, MI, USA) assay kit .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10723784	The luminescence was measured by the FLOUstar OPTIMA plate reader.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "luminescence", "was", "measured", "by", "the", "FLOUstar", "OPTIMA", "plate", "reader", ...
PMC11627133	Two AP3‐SiRA scaffolds exhibited strong binding affinities to SiR with K D values of 366±29 nM (Loop2) and 401±14 nM (F30), while a larger K D of 895±37 nM was observed for the scaffold with Linker (Figure 4B, Figure S6F, G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11486946	In general, assays for drug discovery focus on a particular step in the signaling pathway exhibited by the targeted molecules.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "general", "...
PMC11768927	They found that VSV-rp30 effectively infected and lysed most melanoma cells, even in the presence of IFN.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "found", "that", "VSV-rp30", "e...
PMC6102174	8Structures of compounds 126–137 Structures of compounds 126–137 Hypserpa nitida (Yehuateng), mainly distributed in China and south Asia, is a medicinal herb for treating inflammation in the folk.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	These results indicate that the sensitization of leukemic cells can be induced by activation BTN3A as reported previously as well as with BTN2A1 mAbs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10547921	The oxygen of the methoxy group in Arry-520 may interact weakly with the hydroxyl groups of Tyr211 (3.63 Å).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "oxygen", "...
PMC11075223	Breast cancer was considered to be the most usual invasive cancer in women .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Breast", "cancer", "was", "considered", "to", "be", "the", "most", "u...
PMC11462673	In conclusion, the outcomes of experiments performed in in vivo and in vitro are consistent, collectively demonstrating that LDB1 downregulation demonstrates a tumor-suppressive effect in cases of leukemia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11087766	sfGFP (green) shows the localization of the tagged protein either to the phage nucleus or the cytoplasm. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "sfGFP", "(", "green", ...
PMC10568263	Au@MnO2 nanocomposites were then prepared using a combined approach of hydrothermal and in situ chemical synthesis methods.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Au@MnO2", "nanocomposites", "were", "then", "prep...
PMC11695623	It has been shown that DCUN1D5 is highly expressed in laryngeal squamous cell carcinoma tissues and cells, and overexpression of DCUN1D5 enhances cell proliferation, migration, and invasion and DCUN1D5 may prevent cell cycle progression, thereby promoting repair of damaged DNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10114490	We extended this transcriptional analysis to all genes by RNAseq of PD iHDF-T and diHLC-T. Heatmap and GSEA analysis using Aizarani_hepatocyte and Zabulica gene sets as well as an archetypal HDF gene markers (Additional file 2: Table S3) confirmed silencing of fibroblast gene network and commitment to the hepatocyte ge...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11705547	NPs enter cells through endocytosis, and can therefore effectively deliver cisplatin into drug-resistant tumor cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NPs", "enter", "cells", "through", "endocytosis", ",",...
PMC11388384	Cells were blocked for 1 h at 37 °C in IP blocking buffer comprising 2.5% normal goat serum in PBS, with 0.1% Tween-20.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7090062	c, d Quantitative analysis of miR-30a levels in GIST-T1 and GIST-882 cells treated with imatinib. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "c", ",", "d", "Quantitative", "...
PMC11759543	Cells were seeded on a 24-well plate and cultured for 24 h. Cells were pretreated with 40 μM Z-IETD-FMK for 1 h, then cultured with 0.7 μM doxorubicin and/or 0.6 μM vorinostat in 5637 cells and 0.95 μM doxorubicin and/or 2 μM vorinostat in BFTC 905 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10073922	After 24 hr incubation, the cells that migrated to the lower surface of the transwell were fixed with methanol for five minutes and were stained with 0.1% crystal violet.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11401350	Eighteen hours later the supernatants were harvested and clarified through 0.45 μm filter.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Eighteen", "hours", "later", "the", "supernatants", "were", "harvested", "a...
PMC11473843	Relative cell number of HBEC3-FAK KO cell line transduced either with wild-type FAK (pWZL Hygro-FAK WT) or FAK (pWZL-Hygro-FAK) in the absence or presence of mutKRAS (pBABE-zeo or pBABE-zeo-KRAS ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11443022	Although removal of the calcified scrotal mass during TESE was considered, it was ultimately retained towing to its proximity to the urethra and the lack of symptoms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11271800	This may become a new strategy to enhance GIST monotherapy with imatinib.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "may", "become", "a", "new", "strategy", "to", "enhance", "GIST", "...
PMC9429973	Methods: Publicly available data of five AML cohorts treated with intensive chemotherapy were included in this study: TCGA, n=122; BeatAML, n=230; HOVON (GSE6891), n=392; NTUH (GSE71014), n=104; German (GSE37642), n=136.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11711871	A catheter filled with a solution of glucose (5%) and heparin (3000 IU/ml) was inserted into the vessel.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", ...
PMC11348300	injection as it proved to offer optimal access to tumor tissue (Supplementary Data 5.2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "injection", "as", "it", "proved", "to", "offer", ...
PMC11286266	The knockouts cells were confirmed by Sanger sequencing and immunoblotting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "knockouts", "cells", "were", "confirmed", "by", "Sanger", "sequencing", "and", "immunoblo...
PMC11792766	The experiments utilized several cell lines: the human hepatocyte cell line (HepG2) and the human colon epithelial cell line (Caco‐2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "...
PMC11700247	Upregulation of the IFN type I genes and the induction of crosspresentation led to the hypothesis that the cGAS/STING pathway is relevant to the results observed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	All 420 patients included were in maintenance treatment with antiCD20 MoAb at the time of the onset of SARS-Cov2 pandemic (March 2020): 333 (79%) pts were receiving maintenance after a first line, while 87 (21%) after a second line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11519077	They found that TNF-α, IL-1β, and IL-6 cytokine mRNA levels were decreased in treated groups with CM-MSC or CM-AcMSC compared to the DSS group, according to RT-qPCR data .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11798926	Interestingly, we observed that more PSD95 puncta co-localized with surface AVPA compared to WT SynDIG4, which is primarily found at extrasynaptic sites (Figure 5C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10713411	IL-10 has the ability to induce M2 polarization of tumor-associated macrophages, thus promoting tumor growth in RCC .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IL-10", "has", "the", "ability", "to",...
PMC11727638	Compared to conventional 3D culture methods like microwells and optical tweezers , the Cell Dome system enables the preparation of uniform hemispherical cavities enclosing cells and facilitates essential operations, such as solution manipulation and cell collection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11144200	n = 3. *	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "3", ".", "*" ] } ]
PMC11499381	Cells were gently mixed then incubated on ice for 30 min, followed by a 45 s incubation at 42°C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "wer...
PMC11746948	m Cell viability analysis in A375-GPX4-KO cells infected with WT or mutant Flag-GPX4 constructs, pre-treated with 2-BP, and then treated with RSL3.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "token...
PMC9429973	We observed a significant association between IDA and worse hospitalization outcomes in our nationwide cohort.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "observed", "a", "significant", "association", "between", ...
PMC9429973	FLIPI and POD24 were not good predictors of survival in our cohort, which might be due to our regimen choice and the frequency of imaging follow-up.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11585587	Studies have found that RA has antitumor activity against a variety of solid tumors, and RA may be a promising anticancer compound.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Studies...
PMC4360730	This view highlights two additional facets: ‘Assay category’ and ‘Metadata integrity checks’ found on the curator interface for experimental assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10994876	In summary, based on our knowledge, this study represents one of the initial reports documenting the overexpression of the mutant form of YAP in CHO cells and investigating its impact on cell growth and the production of recombinant proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellL...
PMC7570809	Here, we demonstrate that in HepG2 cell line the RGDechi15D peptide shows an interesting effect in some steps of the metastatic pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC4659567	C NMR (CDCl3, ppm): δ 151.1 (C6), 148.7 (C7a), 130.7 (C4), 126.3 (C2), 122.9 (C3a), 166.7 (C5), 103.4 (C14), 101.9 (C3), 97.7 (C11), 83.6 (C12, C16), 81.7 (C13, C15), 30.6 (C17), 22.3 (C18, C19), 18.1 (C20). [	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Patient and treatment characteristics, ferritin levels and their progression over time, genetic testing for hemochromatosis genes, treatment and outcome were recorded and analyzed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11720107	Interestingly, the Morado garlic extract significantly increased PPARγ mRNA expression by 41.5% compared with the control group (Figure 5A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interes...
PMC9712534	Previous studies demonstrated that TOP2B knockout results in multiple neurological defects, indicating the critical role of TOP2B in neural development.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Previous", "studies", ...
PMC9429973	2012;12(3):191-200.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "2012;12(3):191", "-", "200", "." ] } ]
PMC11489351	The top ten pathways are shown here (see Table S7 for the top 50 pathways).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "top", "ten", "pathways", "are", "sho...
PMC9812014	SINV is an enclosed RNA virus in the genus Alphavirus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SINV", "is", "an", "enclosed", "RNA", "virus", "in", "the", "genus", "Alphavirus", "." ...
PMC10452486	sequences and in documenting the presence of B2m-free HCs from cephalochordates and Agarthans, although in these two groups MHC genes are reported to be lacking .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11615743	The target peak solution was collected for freeze‐vacuum drying.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "target", "peak", "solution", "was", "collected", "for", "freeze‐vacuum", "drying", "." ] } ]
PMC6133382	This infectivity assay was performed by IDEXX BioResearch (Columbia, Missouri, United States).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "infectivity", "assay", "was", "performed", "by...
PMC7189327	Furthermore, their expression patterns were validated by the differential expression analysis based on an external dataset.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "their", "expression", "patter...
PMC7192625	We have shown how users can easily perform integrated analyses of (epi)genomic data in the context of 3D chromatin structure networks, efficiently gaining a quantitative insight on which genome properties potentially display spatial organization patterns in 3D nuclear space.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8073654	These compounds are detailed in Figure 2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "compounds", "are", "detailed", "in", "Figure", "2", "." ] } ]
PMC6379402	We measure this GDV dissimilarity using GDV distance (GDVD), which we compute as follows.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "measure", "this", "GDV", "dissimilarity", ...
PMC11348300	The skin stands out as the primary emitter of PpIX fluorescence, with a rapid increase within the first hour post-i.v.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "skin", "st...
PMC10366908	The hybridomas were produced, as described previously .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "hybridomas", "were", "produced", ",", "as", "described", "previously", "." ] } ]
PMC11686380	Detector gains, offsets, and digital gains were 650.0, 0, and 5.0 for green, and 650.0, 0, and 1.6 for red, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In this series there was high incidence of secondary and adverse prognosis AML, as expected from the high expression of ASXL1 (12.1%) and TP53 (15.2%) mutations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10547921	Silverback's SBT6050 is an anti-HER2 antibody conjugate with TLR8 agonist 91 (Fig. 15) as its payload, which drives a variety of anti-tumor immune mechanisms in a HER2-dependent manner in vitro and has shown good anti-tumor effects in mouse tumor models (Fig. 15).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11792766	The destain solution outlined in Repetto et al. (2008), containing 50% ethanol, 49% deionized water, and 1% glacial acetic acid, is indicative of the affinity of the dye for low pH and acetic acid.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8010066	In one- and five-hour time intervals after incubation, the supernatants were removed and replaced by fresh MEM + L-Glu.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "one-", "and", "f...
PMC11310713	In contrast, the GTB-injected OVX rats did not exhibit characteristics of hyperplasia and showed a morphology like the ovary-intact rats (Fig. 7A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Results: In total 160 patients were included, 31 were diagnosed with CLL, 39 with aggressive NHL, 57 with indolent NHL, 30 with MM and 3 with other HM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3019555	Our results suggest that mRNA–tubulin binding alone is not sufficient to regulate HIF-1α translation but, rather, that the integrity and dynamics of the microtubule cytoskeleton are important for regulation of HIF-1α translation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC1972402	A bispecific monoclonal antibody recognising both carcinoembryonic antigen (CEA) and ricin toxin A chain (RTA) was tested for its ability to target recombinant RTA (r-RTA) to CEA-expressing tumour cells, alone and in combination with ricin B chain (RTB).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721587	Schematic drawing of Fu with its SIM and two inverted phosphorylation-dependent SUMOylation motifs (IPS1 and IPS2) indicated. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Schematic", "drawing", "of",...
PMC11799978	Subsequently, we assessed the direct efficacy of CAF CM on 4T1 cell growth (Figure 3C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", "we", "assessed...
PMC11243198	The identification of BAS 07019774 as a promising GLI antagonist provides a novel starting point for future research aimed at developing improved GLI-targeted compounds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11001582	We conducted grip strength analysis and neither (GR)400, nor (PR)400, nor eGFP knock-in mice showed strength deficits up to 12 months of age (Extended Data Figs. 5c,d and 6c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11420784

Urinary tract infections (UTIs), affecting 150 million people each year globally, are one of the most common bacterial infections .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Urinary...

PMC11740399

The cells were then trypsinized to detach from the culture plates, collected by centrifugation, and resuspended in cold PBS.

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PMC10507284

TROAP knockdown efficiency of siRNA in the SW982 cell line was detected by western blot.

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PMC10560648

A comparison of changes in cell viability showed that the normal lymphocyte cells were able to regenerate 100% of their killed cells during the three times exposed to the venom compared to the survival of the first treatment (24 hours), While the Jurkat cell line was unable to regenerate killed cells during three expos...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11247842

Functional consequences of variants were annotated by VEP with cache files (version 104) for combined annotation of Ensembl and Refseq transcripts.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Functio...

PMC11725127

While small-molecule KRAS inhibitors show promise, they are less effective against other KRAS mutations, such as the G12D mutation.

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PMC9672323

Significant changes are indicated with asterisk (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11756514

Naturally occurring amino acid polymorphisms of langerin can influence the glycan specificity, e.g., it may confer an increased GlcNAc preference as compared to the preference for mannose residues of the WT langerin (63).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11585994

Although there was no significant difference in survival between the G5-sgc8-siBCL11B and G5-siBCL11B groups, a trend towards improved survival was observed (p = 0.0993).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Subcutaneous (SC) delivery of antibody therapies has been shown to be effective and well tolerated and offers several advantages over IV administration in regards to improved healthcare utilization, including ease of administration, reduced treatment burden and reduced hospitalization.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11301242

Changes in ecDNA gene expression levels before and after treatment in the same circular sample.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Changes", "in", "ecDNA", "gene", "expression", "levels", "b...

PMC11194678

Representative images showing protein concentration-dependent LLPS of STAU1.

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PMC4659567

The spectra of 8 recorded on 10% MeOD-d 4/D2O solutions contained only the signals of the p-cymene hydrogens, represented by two pairs of C13,15–H2/C12,16–H2 signals at 5.98/5.74 and 5.38/5.17 ppm (an integral intensity ratio of 1: 1) (Fig 4).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11765988

Diffusion measurements also revealed lower values in sarcoidosis-affected nodes than those with malignant lymphoma.

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PMC11594588

It also leads to nitric oxide synthase (NOS) induction and therefore to NO synthesis.

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PMC11367146

These results confirm that VTE can downregulate the expression of multiple inflammatory mediators.

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PMC11474209

These include sewage, metals, nanomaterials (NMs), personal care products (PPCPs), pharmaceuticals, and persistent organic pollutants (POPs), which discharge into water, contaminate, create a stressful environment, and lead to water pollution .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11593084

We used GraphPad PRISM 6 software for the calculation.

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PMC11532793

We found that the accuracy of the DTE results was not very sensitive to the number of Gibbs or bootstrap samples generated, and that fewer technical replicates are required for good accuracy than is usual for either Salmon or kallisto.

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PMC9429973

All 25 responding pts underwent consolidation, except one that proceeded directly to allogenic stem cell transplantation (HSCT).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "25", "responding", ...

PMC9250505

Scale bars, 50 µm.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", ",", "50", "µm", "." ] } ]

PMC11052306

This compound, 1-G0, was found to be more toxic than cisplatin against leukemia cells (MOLT-4) and breast cancer cells (MCF-7, cisplatin-resistant cell line) but is also very toxic against the benign Chang Liver cells .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "...

PMC9429973

Results: A total of 2,541 records were screened at title/abstract, 441 at full-text and 7 references were identified through other sources.

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PMC11046454

To further assess the therapeutic efficacy of these treatments, the mice were sacrificed on day 42.

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PMC10530622

Relations between a dysbiotic gut microbiota and disease have been established in different physiologic systems, including the gut–kidney axis.

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PMC9847912

We found that an MOI of 9.0 × 10 TCID50 per cell produced MAGIC-5A–detectable titers for nearly all of the viruses that were tested in the spreading infection assay (Table 1), while at the same time avoiding excessive CPE in the CEMss cultures (i.e., ≤40% of cells involved in syncytia).

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PMC11787381

Interestingly, both β2-AR and BuChE are promising and complementary targets for treating AD.

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PMC8777939

Etravirine was administered at the indicated concentrations every two days for seven days.

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PMC11597167

Fluorescence resonance energy transfer (FRET) technology was used to measure the enzymatic activity of BACE1, and measurements were performed by modifying previously used methods and the protocol included in the manufacturer’s (PanVera Corporation, Madison, MI, USA) assay kit .

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PMC10723784

The luminescence was measured by the FLOUstar OPTIMA plate reader.

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PMC11627133

Two AP3‐SiRA scaffolds exhibited strong binding affinities to SiR with K D values of 366±29 nM (Loop2) and 401±14 nM (F30), while a larger K D of 895±37 nM was observed for the scaffold with Linker (Figure 4B, Figure S6F, G).

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PMC11486946

In general, assays for drug discovery focus on a particular step in the signaling pathway exhibited by the targeted molecules.

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PMC11768927

They found that VSV-rp30 effectively infected and lysed most melanoma cells, even in the presence of IFN.

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PMC6102174

8Structures of compounds 126–137 Structures of compounds 126–137 Hypserpa nitida (Yehuateng), mainly distributed in China and south Asia, is a medicinal herb for treating inflammation in the folk.

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PMC9429973

These results indicate that the sensitization of leukemic cells can be induced by activation BTN3A as reported previously as well as with BTN2A1 mAbs.

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PMC10547921

The oxygen of the methoxy group in Arry-520 may interact weakly with the hydroxyl groups of Tyr211 (3.63 Å).

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PMC11075223

Breast cancer was considered to be the most usual invasive cancer in women .

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PMC11462673

In conclusion, the outcomes of experiments performed in in vivo and in vitro are consistent, collectively demonstrating that LDB1 downregulation demonstrates a tumor-suppressive effect in cases of leukemia.

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PMC11087766

sfGFP (green) shows the localization of the tagged protein either to the phage nucleus or the cytoplasm. (

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PMC10568263

Au@MnO2 nanocomposites were then prepared using a combined approach of hydrothermal and in situ chemical synthesis methods.

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PMC11695623

It has been shown that DCUN1D5 is highly expressed in laryngeal squamous cell carcinoma tissues and cells, and overexpression of DCUN1D5 enhances cell proliferation, migration, and invasion and DCUN1D5 may prevent cell cycle progression, thereby promoting repair of damaged DNA.

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PMC10114490

We extended this transcriptional analysis to all genes by RNAseq of PD iHDF-T and diHLC-T. Heatmap and GSEA analysis using Aizarani_hepatocyte and Zabulica gene sets as well as an archetypal HDF gene markers (Additional file 2: Table S3) confirmed silencing of fibroblast gene network and commitment to the hepatocyte ge...

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PMC11705547

NPs enter cells through endocytosis, and can therefore effectively deliver cisplatin into drug-resistant tumor cells .

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PMC11388384

Cells were blocked for 1 h at 37 °C in IP blocking buffer comprising 2.5% normal goat serum in PBS, with 0.1% Tween-20.

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PMC7090062

c, d Quantitative analysis of miR-30a levels in GIST-T1 and GIST-882 cells treated with imatinib. *

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PMC11759543

Cells were seeded on a 24-well plate and cultured for 24 h. Cells were pretreated with 40 μM Z-IETD-FMK for 1 h, then cultured with 0.7 μM doxorubicin and/or 0.6 μM vorinostat in 5637 cells and 0.95 μM doxorubicin and/or 2 μM vorinostat in BFTC 905 cells.

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PMC10073922

After 24 hr incubation, the cells that migrated to the lower surface of the transwell were fixed with methanol for five minutes and were stained with 0.1% crystal violet.

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PMC11401350

Eighteen hours later the supernatants were harvested and clarified through 0.45 μm filter.

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PMC11473843

Relative cell number of HBEC3-FAK KO cell line transduced either with wild-type FAK (pWZL Hygro-FAK WT) or FAK (pWZL-Hygro-FAK) in the absence or presence of mutKRAS (pBABE-zeo or pBABE-zeo-KRAS ).

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PMC11443022

Although removal of the calcified scrotal mass during TESE was considered, it was ultimately retained towing to its proximity to the urethra and the lack of symptoms.

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PMC11271800

This may become a new strategy to enhance GIST monotherapy with imatinib.

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PMC9429973

Methods: Publicly available data of five AML cohorts treated with intensive chemotherapy were included in this study: TCGA, n=122; BeatAML, n=230; HOVON (GSE6891), n=392; NTUH (GSE71014), n=104; German (GSE37642), n=136.

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PMC11711871

A catheter filled with a solution of glucose (5%) and heparin (3000 IU/ml) was inserted into the vessel.

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PMC11348300

injection as it proved to offer optimal access to tumor tissue (Supplementary Data 5.2).

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PMC11286266

The knockouts cells were confirmed by Sanger sequencing and immunoblotting.

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PMC11792766

The experiments utilized several cell lines: the human hepatocyte cell line (HepG2) and the human colon epithelial cell line (Caco‐2).

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PMC11700247

Upregulation of the IFN type I genes and the induction of crosspresentation led to the hypothesis that the cGAS/STING pathway is relevant to the results observed.

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PMC9429973

All 420 patients included were in maintenance treatment with antiCD20 MoAb at the time of the onset of SARS-Cov2 pandemic (March 2020): 333 (79%) pts were receiving maintenance after a first line, while 87 (21%) after a second line.

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PMC11519077

They found that TNF-α, IL-1β, and IL-6 cytokine mRNA levels were decreased in treated groups with CM-MSC or CM-AcMSC compared to the DSS group, according to RT-qPCR data .

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PMC11798926

Interestingly, we observed that more PSD95 puncta co-localized with surface AVPA compared to WT SynDIG4, which is primarily found at extrasynaptic sites (Figure 5C).

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PMC10713411

IL-10 has the ability to induce M2 polarization of tumor-associated macrophages, thus promoting tumor growth in RCC .

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PMC11727638

Compared to conventional 3D culture methods like microwells and optical tweezers , the Cell Dome system enables the preparation of uniform hemispherical cavities enclosing cells and facilitates essential operations, such as solution manipulation and cell collection.

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PMC11144200

n = 3. *

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PMC11499381

Cells were gently mixed then incubated on ice for 30 min, followed by a 45 s incubation at 42°C.

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PMC11746948

m Cell viability analysis in A375-GPX4-KO cells infected with WT or mutant Flag-GPX4 constructs, pre-treated with 2-BP, and then treated with RSL3.

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PMC9429973

We observed a significant association between IDA and worse hospitalization outcomes in our nationwide cohort.

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PMC9429973

FLIPI and POD24 were not good predictors of survival in our cohort, which might be due to our regimen choice and the frequency of imaging follow-up.

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PMC11585587

Studies have found that RA has antitumor activity against a variety of solid tumors, and RA may be a promising anticancer compound.

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PMC4360730

This view highlights two additional facets: ‘Assay category’ and ‘Metadata integrity checks’ found on the curator interface for experimental assays.

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PMC10994876

In summary, based on our knowledge, this study represents one of the initial reports documenting the overexpression of the mutant form of YAP in CHO cells and investigating its impact on cell growth and the production of recombinant proteins.

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PMC7570809

Here, we demonstrate that in HepG2 cell line the RGDechi15D peptide shows an interesting effect in some steps of the metastatic pathway.

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PMC4659567

C NMR (CDCl3, ppm): δ 151.1 (C6), 148.7 (C7a), 130.7 (C4), 126.3 (C2), 122.9 (C3a), 166.7 (C5), 103.4 (C14), 101.9 (C3), 97.7 (C11), 83.6 (C12, C16), 81.7 (C13, C15), 30.6 (C17), 22.3 (C18, C19), 18.1 (C20). [

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PMC9429973

Patient and treatment characteristics, ferritin levels and their progression over time, genetic testing for hemochromatosis genes, treatment and outcome were recorded and analyzed.

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PMC11720107

Interestingly, the Morado garlic extract significantly increased PPARγ mRNA expression by 41.5% compared with the control group (Figure 5A).

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PMC9712534

Previous studies demonstrated that TOP2B knockout results in multiple neurological defects, indicating the critical role of TOP2B in neural development.

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PMC9429973

2012;12(3):191-200.

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PMC11489351

The top ten pathways are shown here (see Table S7 for the top 50 pathways).

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PMC9812014

SINV is an enclosed RNA virus in the genus Alphavirus.

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PMC10452486

sequences and in documenting the presence of B2m-free HCs from cephalochordates and Agarthans, although in these two groups MHC genes are reported to be lacking .

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PMC11615743

The target peak solution was collected for freeze‐vacuum drying.

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PMC6133382

This infectivity assay was performed by IDEXX BioResearch (Columbia, Missouri, United States).

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PMC7189327

Furthermore, their expression patterns were validated by the differential expression analysis based on an external dataset.

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PMC7192625

We have shown how users can easily perform integrated analyses of (epi)genomic data in the context of 3D chromatin structure networks, efficiently gaining a quantitative insight on which genome properties potentially display spatial organization patterns in 3D nuclear space.

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PMC8073654

These compounds are detailed in Figure 2.

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PMC6379402

We measure this GDV dissimilarity using GDV distance (GDVD), which we compute as follows.

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PMC11348300

The skin stands out as the primary emitter of PpIX fluorescence, with a rapid increase within the first hour post-i.v.

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PMC10366908

The hybridomas were produced, as described previously .

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PMC11686380

Detector gains, offsets, and digital gains were 650.0, 0, and 5.0 for green, and 650.0, 0, and 1.6 for red, respectively.

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PMC9429973

In this series there was high incidence of secondary and adverse prognosis AML, as expected from the high expression of ASXL1 (12.1%) and TP53 (15.2%) mutations.

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PMC10547921

Silverback's SBT6050 is an anti-HER2 antibody conjugate with TLR8 agonist 91 (Fig. 15) as its payload, which drives a variety of anti-tumor immune mechanisms in a HER2-dependent manner in vitro and has shown good anti-tumor effects in mouse tumor models (Fig. 15).

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PMC11792766

The destain solution outlined in Repetto et al. (2008), containing 50% ethanol, 49% deionized water, and 1% glacial acetic acid, is indicative of the affinity of the dye for low pH and acetic acid.

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PMC8010066

In one- and five-hour time intervals after incubation, the supernatants were removed and replaced by fresh MEM + L-Glu.

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PMC11310713

In contrast, the GTB-injected OVX rats did not exhibit characteristics of hyperplasia and showed a morphology like the ovary-intact rats (Fig. 7A).

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PMC9429973

Results: In total 160 patients were included, 31 were diagnosed with CLL, 39 with aggressive NHL, 57 with indolent NHL, 30 with MM and 3 with other HM.

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PMC3019555

Our results suggest that mRNA–tubulin binding alone is not sufficient to regulate HIF-1α translation but, rather, that the integrity and dynamics of the microtubule cytoskeleton are important for regulation of HIF-1α translation.

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PMC1972402

A bispecific monoclonal antibody recognising both carcinoembryonic antigen (CEA) and ricin toxin A chain (RTA) was tested for its ability to target recombinant RTA (r-RTA) to CEA-expressing tumour cells, alone and in combination with ricin B chain (RTB).

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PMC11721587

Schematic drawing of Fu with its SIM and two inverted phosphorylation-dependent SUMOylation motifs (IPS1 and IPS2) indicated. (

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PMC11799978

Subsequently, we assessed the direct efficacy of CAF CM on 4T1 cell growth (Figure 3C).

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PMC11243198

The identification of BAS 07019774 as a promising GLI antagonist provides a novel starting point for future research aimed at developing improved GLI-targeted compounds.

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PMC11001582

We conducted grip strength analysis and neither (GR)400, nor (PR)400, nor eGFP knock-in mice showed strength deficits up to 12 months of age (Extended Data Figs. 5c,d and 6c).

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