OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC8336407	All groups were containing 5 wells (N = 5), except for MTT that was performed in triplicate (N = 3) to check the reproducibility.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11782780	However, its effect on the stem-like phenotype of BC cells remains unclear.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "its", "effect", "on", "the", "stem-like", "phenotype", ...
PMC11767817	The chemical structures of the tested compounds and the parental compound, curcumin, are presented in Figure 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "chemical", "structures", "...
PMC11490153	+ low sensitivity (1–2), ++ mild sensitivity (2–3), +++ high sensitivity (3–6), ++++ indicates very high sensitivity (6< ) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594588	Hydroxynonenal was shown in vitro to bind to deoxyguanosine and form a 1,N-propano adduct with a hexyl side chain (Figure 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hydroxy...
PMC11047729	It was found that triptonide induces absolute senescence in U937 and HL-60 cells, as well as inhibiting growth and colony formation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "...
PMC11243198	GLI1 activation creates a positive feedback loop, amplifying the overall Hh response .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GLI1", "activation", "creates", "a", "positive", "feedback", "loop", ",", ...
PMC11682224	GAPDH as control protein; Data are expressed as mean ± standard deviation; N = 6; **P < 0.01.Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GAPDH",...
PMC9429973	Ibrutinib, a Bruton Tyrosine Kinase inhibitor, is a promising drug used in WM, chronic lymphocytic leukemia, mantle cell lymphoma, marginal zone lymphoma, and chronic graft versus host disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8984067	The up-conversion nanoparticles (UCNPs) suitable for biological application can be synthesized with many chemical methods together with further surface functional modification by photosensitizers, hydrophilic groups, targeting agent, specific antibodies, and so on, to facilitate the PDT for deep-tissue cancers, improvi...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11621493	The addition of CaCl2 stimulated phospholipase activity depending on the lipid substrate used, while transacylation reactions were moderately affected.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "addition", "of", ...
PMC9895440	Cells were then expanded 1:2 every two days with fresh medium and 50 U/ml IL-2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "then", "expanded", "1:2", "every", "two", ...
PMC11759751	P < 0.05; P < 0.01; *P < 0.001 We also confirmed the function of chidamide in vivo experiment of subcutaneous tumor transplantation in mice (Fig. 5A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Nat Rev Clin Oncol.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Nat", "Rev", "Clin", "Oncol", "." ] } ]
PMC11365427	siRNAs against DNA Damage Inducible Transcript 3 (DDIT3), Activating Transcription Factor 3 (ATF3), and TNF receptor superfamily member 10b (TNFRSF10B), as well as negative control siRNAs, were constructed by Syngentech Co., Ltd., Beijing, China.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3675084	Thus, new therapy that can overcome paclitaxel resistance will be of significant clinical importance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "new", "therapy", "that", "can", "overcome", ...
PMC9351137	BAF53a, CFDP1, GAS41, and YL1 fluorescent signals were found at the spindle in both metaphase and/or anaphase; Tip60 localized at the centrosome and kinetochores (particularly evident at anaphase).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11342785	When the PKA substrate is phosphorylated in response to cell-signaling inputs, TPPP will be connected to the IDR component to stimulate synMAP circuit activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC8973085	Anal.	[ { "tags": [ "O", "O" ], "tokens": [ "Anal", "." ] } ]
PMC11763111	A Schematic illustration of the (B) (C) (D) MLR (mixed lymphocyte experiment) (n = 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9351137	The figures were constructed in Adobe Photoshop.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "figures", "were", "constructed", "in", "Adobe", "Photoshop", "." ] } ]
PMC8633974	For 400 ng concentration, P= 0.01, Cohen's d=3.71; for 200 ng concentration P=0.04, Cohen's d=3.56; with partial η of 0.71 for treatment (one-way ANOVA for multiple comparisons (n=3) with Dunnett's post hoc test) (g) PCR was performed in extracted DNA from cell lysates using HIV-1 specific primers, followed by agarose ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	No thrombosis nor thrombocytopenia were observed in one month follow-up.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "thrombosis", "nor", "thrombocytopenia", "were", "observed", "in", "one", "month", "follow-...
PMC11574029	Spearman correlation analysis of NOTCH3 and SPP1 protein expression in BLCA specimens.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Spearman", "correlation", "analysis", "of", "NOTCH3", "and", "SPP1", "protein", ...
PMC11463018	Next, various phenylboronic acids were coupled to triazolopyridine scaffold via a Suzuki reaction to obtain intermediates 14a-m.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", ",", "various", "phenylboronic", ...
PMC11560255	We administered the PMBE at concentrations of 50, 100, 200, and 400 µg/ml to HeLa cell cultures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "We", "administered", ...
PMC11380454	The following cells were used in this study: mouse B16/F10 melanoma cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "The", "following", "cells", "were", "used", "in", "this", ...
PMC10582049	Thus, patients with indolent LUAD at early stages often undergo overdiagnosis and overtreatment, whereas individuals with aggressive tumors require urgent therapeutic procedures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11240448	The model-based predictions are further supported by simulating HCC-2157 cell maneuvering in Waddington’s landscape following inhibitor treatments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "model-based", "predictions", ...
PMC11467800	IM was excluded from any injection mixture to avoid pharmacological effects on the embryo and to focus only on cellular dynamics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IM", "was", "excl...
PMC9429973	The classifier was validated through a testing set in a blinded study scheme, and results were compared to the FISH results for c-MYC and BCL2/6 rearrangements (Figure 1A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7823217	Wang et al. developed bioprinted GBM tumor models using glioma cell line U118 within the core of the construct and glioma stem cell, GSC23, on the shell of hydrogel microfibers by coaxial extrusion bioprinting technique (Fig. 4-A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "...
PMC11286266	Cells were also transfected with an empty sgRNA/Cas9 plasmid (pale colour) as control for the transfection effect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "also", "transfec...
PMC11365983	In addition to recapitulating findings of altered meningeal Hh and PDGFRα signaling (Figs. 7 and 8), RNA sequencing demonstrated that the effect on PDGF signaling was specific to Pdgfra, since Pdgfrb mRNA expression was unaffected (Supplemental Fig. 4E; Fig. 8D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11774112	First, it is administered intravenously, a route that is often painful and may lead to patient noncompliance.9 Additionally, DTIC has poor water solubility, leading to incomplete, slow, and inconsistent absorption.10 Furthermore, DTIC is light-sensitive and unstable, contributing to its challenges in clinical use.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11512230	Although the potential primary receptor for the AltMV developed particles it remains unclear, as well as their distribution on the surface of healthy and tumor cells, the increased adherence of AltMV SPV to the membrane of primary ES cells suggests an increased density of unknown primary moieties in the culture of prim...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Summary/Conclusion: AML cell lines have different sensibilities to DDR inhibitors, particularly CCT245737 and niraparib, with the NB-4 cell line appearing to be the most sensitive to DDR inhibition (namely CHK1 and PARP1/2 inhibition), whereas LAMA-84 appears to be the most resistant to this inhibition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Overall response rate in 34 efficacy evaluable pts across all doses was 68%, and 50% achieved a VGPR or better response, including 2/6 BCMA pre-treated pts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11577421	Similarly, a reduction in NP_BSA– uptake was observed in CHO-K1 cells cultured in complete medium.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similarly", ",", "a", "reduction", "in", "NP_...
PMC10605143	This suggests that DTHIB may be further tested in the treatment of TNBC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "suggests", "that", "DTHIB", "may", "be", "further", "tested", ...
PMC9352806	For TG quantification, worms (∼1000 worms each group) were washed from NGM for three times with M9 buffer to collect worm pellets, and homogenized using ultrasonic disruption to release the triglyceride, followed by centrifugation at 8000 rpm for 5 min to obtain the supernatant for TG assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10380508	Silencing PAX8 has been shown to decrease RCC cell proliferation, suggesting it is potentially an oncogene in RCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Silencing", "PAX8", "has", "been"...
PMC11473843	Interestingly, a similar ROS increase was observed by direct inhibition of FAK autophosphorylation with VS-4718 or FAK kinase activity with the ATP-competitive inhibitor, PF-562271 (Figs. 4E and EV4A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11708541	Future research should focus on addressing these challenges, exploring novel synthetic methodologies, and expanding the scope of biological evaluations to fully harness the therapeutic potential of aminopyridines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8584319	Indeed, inhibition of p38 using the inhibitor SB203580 synergistically increased the inhibitory effect of AZD8055 on translation at 8 h in a dose-dependent manner (Figure 5a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11541409	The OXPHOS pathway is a promising therapeutic target in combination with TKI against sensitive KIT/PDGFRA mutants.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "OXPHOS", "pathway", "is", "a", "promising", ...
PMC11790599	The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) plays a dual role in cancer (Rojo de la Vega et al., 2018).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3765139	Differences between groups were assessed by one-way analysis of variance (ANOVA), and differences within each group were analyzed by one-way repeated-measures ANOVA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10547921	For both, the interactions involve their Watson‒Crick, Hoogsteen, and sugar edges.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "both", ",", "the", "interactions", "involve", "their", "W...
PMC11060216	All data generated or analyzed during this study are available, and could be achieved from the corresponding author Dan Dang if required.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", ...
PMC11750161	LH/CGRs mediate intracellular effects through G protein activation (α, β, and γ) (Min et al, 2019, 2020).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC3019555	Stack arithmetic shows trajectory of MB movement. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Stack", "arithmetic", "shows", "trajectory", "of", "MB", "movement", ".", "(" ] } ]
PMC9429973	Double heterozygocity in these genes was found only in preeclamptic women (12/22, 54%, p<0.001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Double", "heterozygocity", "in", ...
PMC11767582	To this end, cytotoxic activities of the cis-restricted analogues of CA-4 prepared were determined in two tumor cell lines, namely, HT-29 and A-549, as well as in the non-tumor cell line HEK-293, to pre-evaluate the selectivity profile of the compounds for the tumor cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLin...
PMC6160470	Interestingly, compounds DAC-2Amide and -3Amide lead to pronounced sensitization of A2780/Adr cells to PTX, comparable to verapamil (Fig. 3a,b, and Table S3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	At 3 months, 15/51 (29%) evaluable patients with CP CML were in CCyR; at 6 months, 17/44 (38.6%) evaluable patients with CP CML were in CCyR and at 12 months, 19/34 (56%) evaluable patients with CP CML were in CCyR. Additionally, 21 (37.5%) and 9 (16%) patients with CP CML achieved a major molecular response (MMR) or a...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10705095	The present study aimed to investigate the role of hemoglobin subunit theta 1 (HBQ1), an α subunit of hemoglobin whose expression has recently been reported in non-erythroid cells, in lung adenocarcinoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10135767	In the present study, we evaluated the calcium bursting of lymphocytes mediated by integrin α4β7 binding with MAdCAM-1 under flow conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", ...
PMC11578343	All HMECs were perturbed at similar frequencies, ranging from 15 to 71 Hz (Figure 5A, ii).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "HMECs", "were", ...
PMC9429973	Only one pt underwent stem cell transplant (SCT) in first remission for persistently detectable BCR/ABL1 transcripts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Only", "one", "pt", "underwent", "stem...
PMC7987994	125 mm · ml Or 0.2 g · ml When cultivation medium with serum is used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "125", "mm", "·", "ml", "Or", "0.2", "g", "...
PMC9429973	Functional experiments with patient-derived t(8;21) cells were performed in co-culture with mesenchymal stromal cells under conditions that preserved and expanded immature VLA-4 expressing leukaemic populations as determined by an 11 antibody panel and flow cytometry analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11569208	PPP4C and PPP4R1, the two dimeric components of PP4, were part of the short list of 38 hits we identified to simultaneously increase VSV∆51 infectivity and oncolysis upon genetic knockdown (Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11657695	B Heatmap showing color-coded expression of genes involved in the Hippo signaling pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "Heatmap", "showing", "color-coded", "expression", "of", "genes", "invo...
PMC11449273	Colony formation results are presented in histograms as means ± SD after normalizing the values of the H1299 mutant p53 cells to p53-WT cells, and the values of the PG-p53 transfectants to their corresponding p53 only expressing cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	While other factors such as sex, bone marrow status, radiotherapy site, pre-harvest hemoglobin, platelet count did not have a statistically significant association.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	28 patients (84.8%) were alive over follow up period.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "28", "patients", "(", "84.8", "%", ")", "were", "alive", "over", "follow",...
PMC11684297	Our findings supported the dissociation of IA, as evidenced by the DLA assay, ThT fluorescence assay, turbidity assay, AFM, and SEM analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Oral tyrosine kinase inhibitors (TKIs) represent the mainstay of chronic myeloid leukemia (CML) therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Oral", "tyrosine", "kinase", "inhibitors", ...
PMC10713411	The results showed that DCN, NTRK2, TRIB3, ATP6V1C2, ATP6V0A4 and PROM2 had a strong correlation with multiple KEGG pathways, and DCN, UCHL1 and TRIB3 were highly correlated with various GO terms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5386478	We used the isoform specific oligonucleotide primers pairs designed by Phatak VM et al. to selectively amplify TGM2 transcripts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "used", "the", "isoform", ...
PMC11562028	With the further extension of the incubation time (8–36 h), the fluorescence intensity in the cells gradually decreased.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", "the", "fu...
PMC11750696	Notably, the study also revealed a delayed disease onset in mice with lymphocytes lacking XBP1 (54), aligning with findings that highlight the induction of Th17 effector functions under hypoxic and osmotic stress conditions (52, 53).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8996378	Most of them were able to reverse MDR, with RF values of 10.05–448.39 at 20 μM. Among them, compound 41 showed the best activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10808409	DSC analysis was used to evaluate the physical stability and phase transition behaviour of FA, TPGS mixed micelles, and blank TPGS mixed micelles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11512230	The qualitative analysis has shown that AltMV SPVLP (Figure S2, lanes 1–3) and AltMV SPV (Figure S2, lanes 4–6) were labeled more effectively than TMV SP (Figure S2, lanes 7–9).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11087055	Live imaging performed at 4 x objective lens on a spinning disk confocal microscope until HH3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Live", "imaging", "performed", "at", "4", "x", "...
PMC7057940	The qPCR primers used to evaluate the EWS-FLI1 promoter region were: set1EWS: Forward, 5′-CCGTAAACCTCCTCCTGCAT-3; and reverse, 5′-AAGCCCTTCACCCTTGCTAA-3, directed towards the sequence of the promoter (24).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11753949	We further investigated the relationship between synaptopodin, actin and the ER by expressing fluorescently tagged synaptopodin (mRFP- or EGFP-synaptopodin) in COS-7 cells, a fibroblastic cell line whose flat morphology facilitates the analysis of these relationships by fluorescence microscopy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", ...
PMC10237474	Intact mass analysis confirmed this observation, although a portion of protein 3 which lost a C-terminal His residue from His6 tag was detected (Fig 2B–2C and 2I).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11727638	Although microwells , optical tweezers , and lymphoma-on-chip allow for 3D culture of lymphoma-derived cells, they require gentle solution manipulation during culture, analysis, and evaluation due to the weak cell-to-cell adhesion of non-adherent cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10914904	Additionally, vtRNA 1-1 inhibits autophagy by preventing p62 oligomerization, and the relevant nucleotides for this proposed role are encircled in red .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11585587	As a result, there is a heightened focus on discovering antineoplastic drugs from phytochemicals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "a", "result", ",", "there", "is", "a", "heighte...
PMC5386478	Furthermore, we assessed the transamidating activity in both conditions by incorporation of 5-(biotinamido)pentylamine (BAP) into proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "we", "assesse...
PMC11543853	However, the released genomes may be degraded by co-endocytosed RNases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "released", "genomes", "may", "be", "degraded", "by", "co-endoc...
PMC9368503	This has contributed to poor reproducibility in preclinical findings which is likely to have played a role in the high failure rate of translating therapeutic discoveries into oncology clinical trials and regulatory approvals .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10490530	Therefore, to rule out the codon bias and improve the scope of this fungal luciferase in biomedical applications as an independent reporter gene, we decided to perform human codon optimization of the native Luz gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11544122	SNX18.13.1 (18-1) and hs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SNX18.13.1", "(", "18", "-", "1", ")", "and", "hs", "." ] } ]
PMC11486946	That is, compounds that can alter EGFR signaling outside tyrosine phosphorylation were successfully selected by the single-molecule tracking-based screening method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "That", "is", ",",...
PMC10674574	In addition, every time a new batch of Caco-2 cells is thawed, a new permeability calibration curve must be generated (using model drugs for each group’s permeability ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11564322	proteins were purchased from ABClonal (Woburn, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "proteins", "were", "purchased", "from", "ABClonal", "(", "Woburn", ",", "USA", ")", "." ...
PMC9812014	An in vitro screening of alkaloid compounds (mostly antimalarial inhibitors) against SARS-CoV-2 showed that alkaloids and alkaloid-based compounds have substantial repressive activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11126803	∗p < 0.1, ∗∗p < 0.01, ∗∗∗ p < 0.001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "∗p", "<", "0.1", ",", "∗∗p", "<", "0.01", ",", "∗∗∗", "p", "<", ...
PMC11544122	Cells were incubated for 1 h at room temperature with anti-FLAG M2 alkaline phosphatase-conjugated antibody diluted 1:1000 in TBS-BSA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "incubated", "for...
PMC11678368	Such a tilt is caused by the formation of two intramolecular N1–H⋯Cl hydrogen bonds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Such", "a", "tilt", "is", "caused", "by", "the", "formation", ...
PMC3734024	Data are representative of four independent experiments. ***	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "representative", "of", "four", "independent", "experiments", ".", "", "", ...
PMC8916024	An OTU rarefaction curve and rank abundance curves were plotted using the R project ggplot2 package (version 2.2.1) (Wickham & Chang, 2008).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8524093	For example, a 14-day-old C57BL/6J WT mice inoculated with 10 pfu of CHIKV by a subcutaneous route in the foot developed gross swelling, severe tenosynovitis, and myositis just in the inoculated foot (Morrison et al., 2011).	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9368503	ICR-SS-1 (2000/well), HS-SY-II (3000/well), and SYO-1 (2000/well) cells were seeded in clear 96-well, flat-bottom plates (Corning Inc., Corning, NY, USA).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC11711663	Moreover, patients with HNSCC have shown higher levels in biomarkers like CA125, tissue polypeptide antigen, and Cyfra21−1 compared to those in control groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC8336407

All groups were containing 5 wells (N = 5), except for MTT that was performed in triplicate (N = 3) to check the reproducibility.

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PMC11782780

However, its effect on the stem-like phenotype of BC cells remains unclear.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "its", "effect", "on", "the", "stem-like", "phenotype", ...

PMC11767817

The chemical structures of the tested compounds and the parental compound, curcumin, are presented in Figure 1.

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PMC11490153

+ low sensitivity (1–2), ++ mild sensitivity (2–3), +++ high sensitivity (3–6), ++++ indicates very high sensitivity (6< ) .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11594588

Hydroxynonenal was shown in vitro to bind to deoxyguanosine and form a 1,N-propano adduct with a hexyl side chain (Figure 4).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hydroxy...

PMC11047729

It was found that triptonide induces absolute senescence in U937 and HL-60 cells, as well as inhibiting growth and colony formation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "...

PMC11243198

GLI1 activation creates a positive feedback loop, amplifying the overall Hh response .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GLI1", "activation", "creates", "a", "positive", "feedback", "loop", ",", ...

PMC11682224

GAPDH as control protein; Data are expressed as mean ± standard deviation; N = 6; **P < 0.01.Fig.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GAPDH",...

PMC9429973

Ibrutinib, a Bruton Tyrosine Kinase inhibitor, is a promising drug used in WM, chronic lymphocytic leukemia, mantle cell lymphoma, marginal zone lymphoma, and chronic graft versus host disease.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8984067

The up-conversion nanoparticles (UCNPs) suitable for biological application can be synthesized with many chemical methods together with further surface functional modification by photosensitizers, hydrophilic groups, targeting agent, specific antibodies, and so on, to facilitate the PDT for deep-tissue cancers, improvi...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11621493

The addition of CaCl2 stimulated phospholipase activity depending on the lipid substrate used, while transacylation reactions were moderately affected.

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PMC9895440

Cells were then expanded 1:2 every two days with fresh medium and 50 U/ml IL-2.

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PMC11759751

P < 0.05; **P < 0.01; ***P < 0.001 We also confirmed the function of chidamide in vivo experiment of subcutaneous tumor transplantation in mice (Fig. 5A).

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PMC9429973

Nat Rev Clin Oncol.

[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Nat", "Rev", "Clin", "Oncol", "." ] } ]

PMC11365427

siRNAs against DNA Damage Inducible Transcript 3 (DDIT3), Activating Transcription Factor 3 (ATF3), and TNF receptor superfamily member 10b (TNFRSF10B), as well as negative control siRNAs, were constructed by Syngentech Co., Ltd., Beijing, China.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC3675084

Thus, new therapy that can overcome paclitaxel resistance will be of significant clinical importance.

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PMC9351137

BAF53a, CFDP1, GAS41, and YL1 fluorescent signals were found at the spindle in both metaphase and/or anaphase; Tip60 localized at the centrosome and kinetochores (particularly evident at anaphase).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11342785

When the PKA substrate is phosphorylated in response to cell-signaling inputs, TPPP will be connected to the IDR component to stimulate synMAP circuit activity.

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PMC8973085

Anal.

[ { "tags": [ "O", "O" ], "tokens": [ "Anal", "." ] } ]

PMC11763111

A Schematic illustration of the (B) (C) (D) MLR (mixed lymphocyte experiment) (n = 3).

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PMC9351137

The figures were constructed in Adobe Photoshop.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "figures", "were", "constructed", "in", "Adobe", "Photoshop", "." ] } ]

PMC8633974

For 400 ng concentration, P= 0.01, Cohen's d=3.71; for 200 ng concentration P=0.04, Cohen's d=3.56; with partial η of 0.71 for treatment (one-way ANOVA for multiple comparisons (n=3) with Dunnett's post hoc test) (g) PCR was performed in extracted DNA from cell lysates using HIV-1 specific primers, followed by agarose ...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

No thrombosis nor thrombocytopenia were observed in one month follow-up.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "thrombosis", "nor", "thrombocytopenia", "were", "observed", "in", "one", "month", "follow-...

PMC11574029

Spearman correlation analysis of NOTCH3 and SPP1 protein expression in BLCA specimens.

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PMC11463018

Next, various phenylboronic acids were coupled to triazolopyridine scaffold via a Suzuki reaction to obtain intermediates 14a-m.

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PMC11560255

We administered the PMBE at concentrations of 50, 100, 200, and 400 µg/ml to HeLa cell cultures.

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PMC11380454

The following cells were used in this study: mouse B16/F10 melanoma cells. (

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PMC10582049

Thus, patients with indolent LUAD at early stages often undergo overdiagnosis and overtreatment, whereas individuals with aggressive tumors require urgent therapeutic procedures.

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PMC11240448

The model-based predictions are further supported by simulating HCC-2157 cell maneuvering in Waddington’s landscape following inhibitor treatments.

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PMC11467800

IM was excluded from any injection mixture to avoid pharmacological effects on the embryo and to focus only on cellular dynamics.

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PMC9429973

The classifier was validated through a testing set in a blinded study scheme, and results were compared to the FISH results for c-MYC and BCL2/6 rearrangements (Figure 1A).

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PMC7823217

Wang et al. developed bioprinted GBM tumor models using glioma cell line U118 within the core of the construct and glioma stem cell, GSC23, on the shell of hydrogel microfibers by coaxial extrusion bioprinting technique (Fig. 4-A).

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PMC11286266

Cells were also transfected with an empty sgRNA/Cas9 plasmid (pale colour) as control for the transfection effect.

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PMC11365983

In addition to recapitulating findings of altered meningeal Hh and PDGFRα signaling (Figs. 7 and 8), RNA sequencing demonstrated that the effect on PDGF signaling was specific to Pdgfra, since Pdgfrb mRNA expression was unaffected (Supplemental Fig. 4E; Fig. 8D).

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PMC11774112

First, it is administered intravenously, a route that is often painful and may lead to patient noncompliance.9 Additionally, DTIC has poor water solubility, leading to incomplete, slow, and inconsistent absorption.10 Furthermore, DTIC is light-sensitive and unstable, contributing to its challenges in clinical use.

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PMC11512230

Although the potential primary receptor for the AltMV developed particles it remains unclear, as well as their distribution on the surface of healthy and tumor cells, the increased adherence of AltMV SPV to the membrane of primary ES cells suggests an increased density of unknown primary moieties in the culture of prim...

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PMC9429973

Summary/Conclusion: AML cell lines have different sensibilities to DDR inhibitors, particularly CCT245737 and niraparib, with the NB-4 cell line appearing to be the most sensitive to DDR inhibition (namely CHK1 and PARP1/2 inhibition), whereas LAMA-84 appears to be the most resistant to this inhibition.

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PMC9429973

Overall response rate in 34 efficacy evaluable pts across all doses was 68%, and 50% achieved a VGPR or better response, including 2/6 BCMA pre-treated pts.

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PMC11577421

Similarly, a reduction in NP_BSA– uptake was observed in CHO-K1 cells cultured in complete medium.

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PMC10605143

This suggests that DTHIB may be further tested in the treatment of TNBC.

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PMC9352806

For TG quantification, worms (∼1000 worms each group) were washed from NGM for three times with M9 buffer to collect worm pellets, and homogenized using ultrasonic disruption to release the triglyceride, followed by centrifugation at 8000 rpm for 5 min to obtain the supernatant for TG assay.

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PMC10380508

Silencing PAX8 has been shown to decrease RCC cell proliferation, suggesting it is potentially an oncogene in RCC.

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PMC11473843

Interestingly, a similar ROS increase was observed by direct inhibition of FAK autophosphorylation with VS-4718 or FAK kinase activity with the ATP-competitive inhibitor, PF-562271 (Figs. 4E and EV4A).

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PMC11708541

Future research should focus on addressing these challenges, exploring novel synthetic methodologies, and expanding the scope of biological evaluations to fully harness the therapeutic potential of aminopyridines.

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PMC8584319

Indeed, inhibition of p38 using the inhibitor SB203580 synergistically increased the inhibitory effect of AZD8055 on translation at 8 h in a dose-dependent manner (Figure 5a).

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PMC11541409

The OXPHOS pathway is a promising therapeutic target in combination with TKI against sensitive KIT/PDGFRA mutants.

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PMC11790599

The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) plays a dual role in cancer (Rojo de la Vega et al., 2018).

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PMC3765139

Differences between groups were assessed by one-way analysis of variance (ANOVA), and differences within each group were analyzed by one-way repeated-measures ANOVA.

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PMC10547921

For both, the interactions involve their Watson‒Crick, Hoogsteen, and sugar edges.

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PMC11060216

All data generated or analyzed during this study are available, and could be achieved from the corresponding author Dan Dang if required.

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PMC11750161

LH/CGRs mediate intracellular effects through G protein activation (α, β, and γ) (Min et al, 2019, 2020).

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PMC3019555

Stack arithmetic shows trajectory of MB movement. (

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PMC9429973

Double heterozygocity in these genes was found only in preeclamptic women (12/22, 54%, p<0.001).

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PMC11767582

To this end, cytotoxic activities of the cis-restricted analogues of CA-4 prepared were determined in two tumor cell lines, namely, HT-29 and A-549, as well as in the non-tumor cell line HEK-293, to pre-evaluate the selectivity profile of the compounds for the tumor cell lines.

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PMC6160470

Interestingly, compounds DAC-2Amide and -3Amide lead to pronounced sensitization of A2780/Adr cells to PTX, comparable to verapamil (Fig. 3a,b, and Table S3).

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PMC9429973

At 3 months, 15/51 (29%) evaluable patients with CP CML were in CCyR; at 6 months, 17/44 (38.6%) evaluable patients with CP CML were in CCyR and at 12 months, 19/34 (56%) evaluable patients with CP CML were in CCyR. Additionally, 21 (37.5%) and 9 (16%) patients with CP CML achieved a major molecular response (MMR) or a...

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PMC10705095

The present study aimed to investigate the role of hemoglobin subunit theta 1 (HBQ1), an α subunit of hemoglobin whose expression has recently been reported in non-erythroid cells, in lung adenocarcinoma.

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PMC10135767

In the present study, we evaluated the calcium bursting of lymphocytes mediated by integrin α4β7 binding with MAdCAM-1 under flow conditions.

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PMC11578343

All HMECs were perturbed at similar frequencies, ranging from 15 to 71 Hz (Figure 5A, ii).

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PMC9429973

Only one pt underwent stem cell transplant (SCT) in first remission for persistently detectable BCR/ABL1 transcripts.

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PMC7987994

125 mm · ml Or 0.2 g · ml When cultivation medium with serum is used.

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PMC9429973

Functional experiments with patient-derived t(8;21) cells were performed in co-culture with mesenchymal stromal cells under conditions that preserved and expanded immature VLA-4 expressing leukaemic populations as determined by an 11 antibody panel and flow cytometry analysis.

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PMC11569208

PPP4C and PPP4R1, the two dimeric components of PP4, were part of the short list of 38 hits we identified to simultaneously increase VSV∆51 infectivity and oncolysis upon genetic knockdown (Table 1).

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PMC11657695

B Heatmap showing color-coded expression of genes involved in the Hippo signaling pathway.

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PMC11449273

Colony formation results are presented in histograms as means ± SD after normalizing the values of the H1299 mutant p53 cells to p53-WT cells, and the values of the PG-p53 transfectants to their corresponding p53 only expressing cells.

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PMC9429973

While other factors such as sex, bone marrow status, radiotherapy site, pre-harvest hemoglobin, platelet count did not have a statistically significant association.

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PMC9429973

28 patients (84.8%) were alive over follow up period.

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PMC11684297

Our findings supported the dissociation of IA, as evidenced by the DLA assay, ThT fluorescence assay, turbidity assay, AFM, and SEM analysis.

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PMC9429973

Oral tyrosine kinase inhibitors (TKIs) represent the mainstay of chronic myeloid leukemia (CML) therapy.

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PMC10713411

The results showed that DCN, NTRK2, TRIB3, ATP6V1C2, ATP6V0A4 and PROM2 had a strong correlation with multiple KEGG pathways, and DCN, UCHL1 and TRIB3 were highly correlated with various GO terms.

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PMC5386478

We used the isoform specific oligonucleotide primers pairs designed by Phatak VM et al. to selectively amplify TGM2 transcripts.

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PMC11562028

With the further extension of the incubation time (8–36 h), the fluorescence intensity in the cells gradually decreased.

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PMC11750696

Notably, the study also revealed a delayed disease onset in mice with lymphocytes lacking XBP1 (54), aligning with findings that highlight the induction of Th17 effector functions under hypoxic and osmotic stress conditions (52, 53).

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PMC8996378

Most of them were able to reverse MDR, with RF values of 10.05–448.39 at 20 μM. Among them, compound 41 showed the best activity.

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PMC10808409

DSC analysis was used to evaluate the physical stability and phase transition behaviour of FA, TPGS mixed micelles, and blank TPGS mixed micelles.

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PMC11512230

The qualitative analysis has shown that AltMV SPVLP (Figure S2, lanes 1–3) and AltMV SPV (Figure S2, lanes 4–6) were labeled more effectively than TMV SP (Figure S2, lanes 7–9).

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PMC11087055

Live imaging performed at 4 x objective lens on a spinning disk confocal microscope until HH3.

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PMC7057940

The qPCR primers used to evaluate the EWS-FLI1 promoter region were: set1EWS: Forward, 5′-CCGTAAACCTCCTCCTGCAT-3; and reverse, 5′-AAGCCCTTCACCCTTGCTAA-3, directed towards the sequence of the promoter (24).

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PMC11753949

We further investigated the relationship between synaptopodin, actin and the ER by expressing fluorescently tagged synaptopodin (mRFP- or EGFP-synaptopodin) in COS-7 cells, a fibroblastic cell line whose flat morphology facilitates the analysis of these relationships by fluorescence microscopy.

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PMC10237474

Intact mass analysis confirmed this observation, although a portion of protein 3 which lost a C-terminal His residue from His6 tag was detected (Fig 2B–2C and 2I).

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PMC11727638

Although microwells , optical tweezers , and lymphoma-on-chip allow for 3D culture of lymphoma-derived cells, they require gentle solution manipulation during culture, analysis, and evaluation due to the weak cell-to-cell adhesion of non-adherent cells.

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PMC10914904

Additionally, vtRNA 1-1 inhibits autophagy by preventing p62 oligomerization, and the relevant nucleotides for this proposed role are encircled in red .

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PMC11585587

As a result, there is a heightened focus on discovering antineoplastic drugs from phytochemicals.

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PMC5386478

Furthermore, we assessed the transamidating activity in both conditions by incorporation of 5-(biotinamido)pentylamine (BAP) into proteins.

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PMC11543853

However, the released genomes may be degraded by co-endocytosed RNases.

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PMC9368503

This has contributed to poor reproducibility in preclinical findings which is likely to have played a role in the high failure rate of translating therapeutic discoveries into oncology clinical trials and regulatory approvals .

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PMC10490530

Therefore, to rule out the codon bias and improve the scope of this fungal luciferase in biomedical applications as an independent reporter gene, we decided to perform human codon optimization of the native Luz gene.

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PMC11544122

SNX18.13.1 (18-1) and hs.

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PMC11486946

That is, compounds that can alter EGFR signaling outside tyrosine phosphorylation were successfully selected by the single-molecule tracking-based screening method.

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PMC10674574

In addition, every time a new batch of Caco-2 cells is thawed, a new permeability calibration curve must be generated (using model drugs for each group’s permeability ).

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PMC11564322

proteins were purchased from ABClonal (Woburn, USA).

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PMC9812014

An in vitro screening of alkaloid compounds (mostly antimalarial inhibitors) against SARS-CoV-2 showed that alkaloids and alkaloid-based compounds have substantial repressive activity.

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PMC11126803

∗p < 0.1, ∗∗p < 0.01, ∗∗∗ p < 0.001.

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PMC11544122

Cells were incubated for 1 h at room temperature with anti-FLAG M2 alkaline phosphatase-conjugated antibody diluted 1:1000 in TBS-BSA.

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PMC11678368

Such a tilt is caused by the formation of two intramolecular N1–H⋯Cl hydrogen bonds.

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PMC3734024

Data are representative of four independent experiments. ***

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PMC8916024

An OTU rarefaction curve and rank abundance curves were plotted using the R project ggplot2 package (version 2.2.1) (Wickham & Chang, 2008).

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PMC8524093

For example, a 14-day-old C57BL/6J WT mice inoculated with 10 pfu of CHIKV by a subcutaneous route in the foot developed gross swelling, severe tenosynovitis, and myositis just in the inoculated foot (Morrison et al., 2011).

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PMC9368503

ICR-SS-1 (2000/well), HS-SY-II (3000/well), and SYO-1 (2000/well) cells were seeded in clear 96-well, flat-bottom plates (Corning Inc., Corning, NY, USA).

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PMC11711663

Moreover, patients with HNSCC have shown higher levels in biomarkers like CA125, tissue polypeptide antigen, and Cyfra21−1 compared to those in control groups.

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