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OTAR3088
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PMC7053076
However, its application is now limited due to the serious side-effects and the development of resistance .
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PMC8557138
Pathological angiogenesis of either excessive (tumors, diabetic retinopathy) or insufficient (ischemic diseases) vessel growth is a consequence surrounding aberrated secretome.
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PMC9429973
Outcomes were compared at 26 weeks using unanchored MAIC between PEG versus RAV and PEG versus ECU and included mean and percent change in LDH levels from baseline, LDH normalization (defined as LDH levels dropping <1xULN [246 U/L] in the absence of transfusions during the randomized controlled period), Hb stabilizatio...
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PMC7022782
In particular, the NPs here studied showed a particle size (<200 nm) suitable not only for the accumulation in tumor tissues by enhanced permeability and retention effect but also for endocytosis by tumor cells.
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PMC9429973
All stained samples were acquired on a Canto II (BD Bioscience) flow cytometer and analyzed using DIVA software version 8.0.2.
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PMC11740573
For both strains of EC, in column 7 no color change was observed, therefore the concentration in that column (8 µg/ml) was taken as the MIC value To analyze the potential of calcitriol to decrease the MIC of antibiotics, we prepared in 96-well microtiter plates the same serial dilutions of each antibiotic as described ...
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PMC11361748
For K17 immunoprecipitation (IP), Dynabeads Protein A Immunoprecipitation Kit (Invitrogen #10006D) was used, and 50 μl of beads was incubated with 2 μl of rabbit polyclonal K17 antibody at 4°C overnight.
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PMC7841189
Han et al. reported that both LTBP2 mRNA and protein levels were significantly higher in head and neck squamous cell carcinoma (HNSCC) tissues, and its expression level was related to lymph node metastasis and higher pTNM stages16.
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PMC9429973
Despite the wide variety of studies in this field, there are still unsolved issues regarding their biology, disease course, prognosis and treatment.
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PMC10955424
IL-6, the cytokine found to correlate with induction of chemoresistance in A2780cisR by ascites fluid is known to activate the JAK/STAT signal transduction pathway .
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PMC10135767
The typical time course of calcium signaling showed that the concentration differences of MAdCAM-1 had a significant effect on the production of cellular calcium signaling (Figure 3A).
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PMC11665584
The proportions of cells captured from control and PITX1 wounds were relatively equal: keratinocytes (33.8%/32.3%; control/PITX1), immune cells (56.5%/59.2%), fibroblasts (5.4%/6.3%), vascular cells (2.2%/1.4%), melanocytes (0.4%/0.4%), and skeletal muscle cells (1.7%/0.4%).
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PMC11394730
These findings raise the possibility of using emodin as an anticancer medication .
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PMC10582049
However, it is still not clear if CAFs act only as a pro-tumorigenic factor or, depending on the context, they can play an anti-tumorigenic role.
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PMC11442172
Nevertheless, reductions in amino acid (43) and especially de novo nucleotide synthesis (24, 43, 45) were also reported for 3D models compared to their 2D counterparts.
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PMC9429973
The association between TET2 mutations and extrinsic epigenetic aging indicates that TET2 mutated clones may be drivers of immunosenescence, while the association between DNMT3A mutations and intrinsic epigenetic aging may be due to increased stem cell proliferation rates in individuals with DNMT3A mutations.
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PMC9429973
Notably, leukemic driver mutations, affecting genes such as IDH2, TP53 and KRAS, were already traceable at very low allele frequency in the chronic phase of the disease of all patients, despite being undetectable by bulk diagnostic NGS analysis.
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PMC9917080
However, after a 48-h preincubation of the cells with the studied agents, a pronounced depletion of the ER occurred and thapsigargin evoked low-amplitude Ca-responses, and after exposure with SeSo, thapsigargin induced a slow increase in [Ca]i (Figure 8C,E).
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PMC11732523
Cardiac and abdominal examinations were unremarkable.
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PMC10530622
Secondary hyperoxaluria is mainly related to environmental factors (diet, lifestyle, and geographical, climatic, and ethnic factors (for a recent review, see )).
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PMC7294030
5-FU (Boryung Pharmaceutic Co., Ltd. Korea) was aliquoted and kept at 4C.
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PMC11694066
Such a “BRCAness” phenotype was not observed in our study, in which we could detect adequate RAD51 foci formation in DSRCT cells exposed to PARPi.
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PMC11629143
The authors declare no conflicts of interest.
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PMC11739696
These findings thus underscore the multifaceted and deleterious impact of Co3O4NPs on aggressive melanoma A-375 cells, highlighting the need for further studies to assess the possibility of using Co3O4NPs in melanoma therapy.
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PMC11471176
These inventive drug delivery approaches addressed the issue of rapid degradation and led to a notable decrease in the 50 % inhibitory concentration (IC50) of carnosine.
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PMC9429973
Severely immune compromised patients started to be contacted in December 2021 to offer them a fourth dose of vaccine.
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PMC11301242
Comparative analysis of gene expression levels involved in DNA repair pathways in lymphoma cell lines.
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PMC11285179
This significant difference suggested that CCL28 may play a pivotal role in influencing pericyte populations within the tumor microenvironment.
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PMC9429973
All the patients were treated with an immuno-chemotherapy (R-CHOP=23, R-ACVBP=6).
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PMC3274243
8701-BC cells were cultured on sections of the conductive gold ink coated ceramic probe.
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PMC11750712
Inclusion criteria are: male or female, aged ≥18 years; willing and able to give written, informed consent to be screened for TRBC1-positive T-NHL and to enter the main study; confirmed diagnosis of selected T-NHL including PTCL-NOS, or AITL or ALCL; confirmed TRBC1-positive tumor; relapsed or refractory disease and ha...
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PMC9583612
Thus, multiple measurements at a single facility are treated as independent and equally valid data points and are averaged with equal weight to all other measurements.
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PMC11701801
The cells were then reseeded and transfected repeatedly with the indicated siRNAs for 48 hours.
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PMC10631132
A higher degree of ALP expression was observed in fibroblast-derived iPSCs differentiated under the MB protocol (Fig. 2K) in comparison with the PBMC-derived iPSCs (Fig. 2E).
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PMC9429973
SBNO2 was overexpressed in both, STAT3-transformed mHSPC (versus STAT3) and T-LGLL patients harbouring STAT3 mutations (versus T-LGLL patients with wild type STAT3).
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PMC9910796
Note also that vEP84Ri particles contain a normal outer capsid (ca, green) and acquire their outer envelope (oe, purple) by budding (J) at PM, as occurs with vEP84Ri particles (E).
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PMC11767582
The last step of our synthesis was the coupling of azide 1 with aromatic alkynes 2, as well as other commercially available terminal alkynes.
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PMC9545474
Results are expressed as a selectivity index (SI), defined as the ratio of the mean IC50 value for normal PNT2 cells divided by the mean IC50 value for each individual cancer cell line (Table S5 and Figure 5).
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PMC11248911
C NMR (DMSO-d6, δ ppm): 16.28, 46.78, 47.35, 63.27, 125.75, 127.19, 127.74, 128.08, 128.44, 140.13, 143.72, 158.52, 175.94.
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PMC9429973
Clinicopathological characterization of LSC-associated genes with convenient assessment tools such as immunohistochemistry (IHC) is needed.
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PMC11656380
Human T-ALL cells and human primary peripheral blood mononuclear cell (PMBC) were incubated with 3 μM of fluorescent-labeled Tamra-Tat-Ram13 (red) for 30 min, and subsequently observed by confocal fluorescent microscopy.
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PMC9429973
OR at day 28 was reached by 8 (38%) of patients in the placebo arm and by 12 (60%) in the MSC arm (odds ratio = 2.48, 95% confidence interval (CI) 0.65-9.51, p = 0.19).
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PMC10788478
In the lung adenocarcinoma subgroup, LGR6 overexpression was significantly associated with vascular invasion and the wild‐type EGFR genotype, and tended to be associated with male sex, smoking, and lymphatic permeation (Table 2).
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PMC11469524
For stimulation studies, BL-2 and BL-41 cells were cultured in RPMI1640 with 10% FCS at 3x10 cells/ml and incubated with 1.3μg/ml goat α-IgM F(ab)2 fragments (Jackson Immunity) for indicated time points.
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PMC10810426
In both cases, co-localization of capsid was detected with both NUP358 and NUP62 (Fig 6B and 6C).
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PMC11640555
Immunofluorescence analysis for ZO-1 and Occludin highlights how LPS produced an increasing amount of ZO-1 and Occludin proteins (Figure 7B and Figure 7G, respectively for ZO-1 and Occludin), distributed away from the edges of the brain endothelial cells resulting in a misty appearance in the cytoplasm in comparison wi...
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PMC10291556
The selective killing of cancerous cells by Pt(IV) complexes 2–4 was demonstrated based on different morphology (shape, structure, form, and size) of cancerous HCT-116 (epithelial, tile-like morphology) and non-cancerous MRC-5 cells (fibrous) morphology (see the different morphologies of HCT-116 and MRC-5 cells on Figu...
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PMC11543885
Replace the Nigericin-containing medium with warmed medium with 500 μM biotin-phenol (BP).
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PMC11411131
High concentrations of toxicants can lead to cell death.
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PMC10890055
The concentration of Ag in the diluted extracts was below 1.8 nmol∙L and was considered to have a minor effect.
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PMC11585565
Our analyses of the crystal structure using the Mg-bound cytosolic fragment of CNNM2 (PDB: 6N7E) showed that Gly565 in CNNM2, equivalent to Gly492 in CNNM4, was located far from Mg-ATP.
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PMC9429973
The cytotoxicity was higher in lower-risk MDS-lymphocytes than in high-risk MDS-lymphocytes, and S100a9 partially rescue the exhausted cytotoxicity in lymphocytes.
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PMC11770199
PCDH-p14, PCDH-mCherry-p14, and pCW57-p14 were constructed in our laboratory and sequenced by Sangon Biotech.
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PMC11802855
In the CXCL7-OE RPMI8226 (G) and H929 (H) cell lines, the incorporation of JAK1 inhibitors gave rise to a significant reduction in the expression levels of p-STAT3, MMP13, and C-myc.
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PMC9429973
Image: Summary/Conclusion: These preliminary data show several factors significantly associated with tx use, suggesting that in some pts with IR-MDS, AZA is more likely to be used versus SC when these factors are considered.
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PMC3035438
We inserted the human IgHG1 fragment into the intronic sequences between exons CH1 and CH2 of the chicken Ig mu heavy-chain constant region (chicken IgHM).
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PMC11684269
Kidney immune homeostasis is intricately linked to T cells.
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PMC11765879
ZR-75-1, SK-BR-3, and MCF-10A cell lines were seeded in 6-well plates (Thermo Fisher Scientific) in supplemented RPMI-1640 media at a density of 250,000 cells/well and then incubated overnight.
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PMC9429973
While RNA-seq of the AML cell line OCI-AML3 and CD34 positive cells showed only subtle gene expression changes in phospholipid metabolism upon LPIN1 KD, lipidomics analyses revealed significant differences in the composition of phospholipids upon LPIN1 KD.
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PMC9429973
Authors FS and EJ contributed equally.
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PMC7887261
A main strength of the study is the focus on LC patients with extreme phenotypes of known risk factors (i.e., early-onset, FHLC, or familial cases in high-risk families), which provide >5 times statistical power.
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PMC11740508
2 × 10 cells/well in 6-well plates were treated for 6 days.
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PMC9429973
In vitro treatment with the BCL2 inhibitor Venetoclax (VEN), resulted in increased MCL1 expression, suggesting a resistance mechanism to this therapy.
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PMC9065483
Furthermore, expression of the VSV matrix (M) and nuclear (N) genes were significantly decreased upon addition of gefitinib compared with vanadate-only-treated cells 24 hpi as measured by qPCR (Figure 2E).
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PMC9388315
β-actin was used as the internal control to normalize intensity values.
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PMC11258145
Significant differences were marked with different letters: for the SK-N-SH cell line—uppercase letters; for the HL-60 cells—lowercase letters.
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PMC7342409
Our previous research suggests the possibility of activation of the RAS-RAF-MEK-ERK pathways driven by a KIT-independent oncogenic mechanism in GISTs.18 In imatinib-resistant GISTs with both KIT V559D and BRAF V600E mutations, the inhibition of KIT V559D by imatinib caused a strong decrease of AKT phosphorylation, whil...
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PMC11467964
Wang et al. established a signature containing GREM2 for clear renal cell carcinoma.
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PMC11543885
For the activation of other inflammasomes, it is important to employ appropriate and specific inducers.
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PMC10958426
We identified total 204 DEGs between tumor associated endothelial cells and normal endothelial cells, of which 100 genes were tumor associated endothelial cell specific and 104 genes were normal endothelial cell specific (Fig. S3A).
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PMC8270637
Since PD-1 and CTLA-4 are the main immunosuppressive molecules on the surface of T cells, which negatively regulate T cells functions.
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PMC11204465
This method is a novel approach to the synthesis of AF.
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PMC10988555
To further understand the binding of complex 2, 3, and 4 to DNA, incubation of complexes 2–4 in the presence of different concentrations of calf thymus DNA (CT-DNA) was evaluated by UV-spectroscopy (Figure S17).
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PMC11519077
Of the 11 members of the IL-1 family, it is also the most researched and best characterized .
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PMC9429973
Additionally, cytokine and chemokine release were analyzed in serum four hours after the first treatment injection and in tumor supernatant 3 days after the first treatment injection.
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PMC11723947
The sample HP1g-S12 was excluded from the analysis because its per sequence GC content, percentage of reads mapped to exonic regions and 5’-3’ bias were abnormal.
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PMC11588085
Moreover, our GSEA revealed an enrichment of the mesenchymal to epithelial transition (MET) pathway in sgXIST7 and sgXIST9 after hypoxia treatment compared to their normoxia condition counterparts (Fig. 6B).
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PMC11697065
The culture medium was supplemented with bolus additions of a proprietary nutrient feed over the course of the fed-batch process with lactate and glucose monitored using a YSI (2900D, YSI Inc).
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PMC9429973
MVA showed American Indian/Alaska Native, and Black race as independent prognostic variables for worse OS, and Yost group 2 and 3, representing higher SES, were found to be significant independent prognostic variables for improved OS (Table 1).
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PMC11543885
Elute the biotinylated proteins via boiling the beads in 60 μL 3 x Laemmli loading buffer (supplemented with 2 mM biotin and 20 mM DTT) at 98°C for 10 min.
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PMC11720808
Figure 5SCU inhibits OS cell proliferation through TLR4 in vitro. (
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PMC10958426
However, most studies focused on how tumor subclones involved in complex tumor ecosystem [, , , ].
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PMC11742047
Cells were washed with cold PBS, centrifuged and the pellets were stored at − 80 °C until the day of the analysis.
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PMC9019892
The reaction in each tube was started immediately by adding ATP and kept going for an hour at room temperature.
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PMC11680391
This study could be improved by increasing the sample size and include open-ended questions to motivate the respondents to elaborate on the topics they found most important.
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PMC11684821
In contrast to the over 42% of CDR3-α in this study that use TRAJ42 with a preserved tyrosine, only 1.45% of TCR-α chains deposited in the VDJdb database have the same characteristic (26) (Figure 3E), and only 0.87% of CDR3s on the VDJdb database have deleted the asparagine but maintained the tyrosine from the TRAJ42 g...
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PMC11680982
However, further investigation is required to examine whether anti-HER2 macromolecular monoclonal antibodies also enhance the efficacy of CDK 4/6 inhibitors combined with endocrine therapy in HR/HER2-low breast cancer.
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PMC11522251
p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001, siHOXB8-1 or siHOXB 8–2 relative to si-NC.
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PMC9429973
According to the IPS-model, 143 (12.9%) patients were high-risk (IPS 5-7).
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PMC11306331
However, while the presence or absence of condensates was well predicted by 3xFUS concentration, we observed that the dilute phase 3xFUS concentration did not plateau at a well-defined saturation concentration, as would be expected for a simple single-component condensate, but instead continued increasing with total nu...
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PMC9817179
The expression level of EGFP-EWS(IDR) here is significantly higher than in Figure 1A.
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PMC10047551
In NSCLC biopsies, the inverse correlation between the methylation and expression of PD-L1 was weak.
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PMC10840195
In zebrafish research, we confirmed the similarity of Twist overexpression and sunitinib resistance, and the promoting effect of Twist overexpression on drug resistance.
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PMC9454178
Data from the public GEO database and tissue microarray were used to analyse the gene expression levels of CDKs in GISTs.
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PMC11806182
Moreover, survival analysis revealed that fibroblasts.8 and CD4.T.cells.1 were both significantly linked to poorer overall survival in UCEC patients (Fig. 7C, D).
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PMC11794588
Fig. 12Mass spectra of Compound 4 (2-Pentadecanone, 6,10,14-Trimethyl) and its structure.
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PMC11240448
Exploring the limits of molecular features and perturbations necessary for cSTAR to work reliably, we found that a limited number of molecular features and perturbations reported in Ref.
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PMC9118379
The middle peptide level disambiguates variant peptide sequences by examining (1) isobaric substitutions and semitryptic cleavage and (2) spectral counting.
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PMC9581083
TCM theories relating to infectious diseases were further developed during the Tang, Song and Yuan dynasties.
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PMC11023271
FB essence (FBE) is a cost effective alternative to FBS and contains a mixture of FBS, Bovine Calf Serum, Equine Serum, and a proprietary blend of supplements, vitamins, minerals, and growth factors.
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