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PMC8777939
Metastasis ovarian cancer is an advanced stage malignancy in which ovarian cancer cells spread from the primary tumor to distant areas such as the peritoneal cavity, omentum , liver , intestines, spleen , lungs , brain , and lymph nodes outside the abdomen .
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PMC11388384
By asking how SHH morphogen gradient size can be regulated, we found that prior models of morphogen diffusion could not adequately describe formation of SHH gradients (39–41).
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PMC11705901
rs4686302 is in complete LD with rs53576 and it’s a missense mutation (can lead to amino acid change), thus it was assayed in place of rs53576.
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PMC11726848
After irradiation in the LDR and HDR modes, a dose-dependent decrease in the number of cells was observed 72 h after the start of irradiation (Figure 3A).
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PMC11138140
Therefore, it may be difficult to uncouple norepinephrine-dependent and independent effects on cardiomyocyte hypertrophy when measuring only surface area.
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PMC9429973
L. Verweij, Y. Smit, N. Blijlevens, R. Hermens Hematology; IQ Healthcare, Radboudumc, Nijmegen, Netherlands Background: Substantial proliferation of eHealth has enabled a move in patient-centred cancer care from the traditional in-person care model to real-time, dynamic, and technology supported on-demand care.
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PMC11047729
Retinol undergoes various changes inside the human body, as shown in Figure 5.
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PMC6222635
As the medicinal materials market has grown, the demand for the medicinal plant Dendrobium officinale has increased dramatically .
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PMC11155445
Naphthalene-based acyl thiourea conjugates (122a–j) were synthesized and evaluated as inhibitors of alkaline phosphatase by Saeed et al. All compounds exhibited good inhibitory activity against AP with IC50 values between 0.365 ± 0.011 and 4.225 ± 1.054 μM. Compounds (122h and 122a) were found most potent inhibitors of...
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PMC11578343
Using a four‐zone device with a 6‐mm zone length, we measured the viscoelasticity of three breast epithelial cell lines: non‐malignant MCF‐10A, malignant MCF‐7, and invasive MDA‐MB‐231.
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PMC11746948
ZDHHC20 depletion or inhibition of protein palmitoylation by 2-BP sensitizes cancer cells to ferroptosis.
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PMC11612794
Phosphorylation of the Dsn1 basic motif by Aurora B precludes the mask by inhibiting the basic motif binding to the Nsl1 acidic surface.
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PMC10135767
The activation of immunoreceptors, including T cell, B cell, and Fc receptors, as well as chemokine and co-stimulatory receptors, results in an increase in intracellular Ca levels .
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PMC11594806
Studies show that DTX can increase CD73 expression and enzymatic activity in patient-derived ovarian epithelial and CD8+ T cells, leading to an immunosuppressive response that can be reversed by anti-CD73 (aCD73) antibodies.
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PMC7917457
∗∗∗p < 0.001.
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PMC9429973
MRD negativity was achieved by 12/16 (75%) patients with CR or CRi, primarily after Cycle 1 (Cycle 1: n=8; Cycle 2: n=2; Cycle 3: n=1; Cycle 4: n=1).
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PMC10957991
184A1 mammary epithelial cells were plated very sparse (around 10% confluency) on collagen-coated CytoSoft® cell culture dishes with 0.2, 2, 16 and 64 kPa stiffnesses (Merck/Sigma Adrich).
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PMC11066331
Mass spectra were acquired in the linear positive ion mode, in mass region 2–20 kDa, with pulse extraction set to 12.5 kDa.
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PMC11683240
We used this nomenclature to abbreviate the names.
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PMC11204465
Removal of the two phenyl-protecting groups by hydrogenation, followed by acylation of the phenol and hemiacetyl hydroxyl groups and high-temperature pyrolysis (450 °C) to form a C-ring double bond.
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PMC9429973
TNF-α levels overproduction and promoter polymorphisms at TNF-α 238 alleles may play a central role in reduced red cell production and malaria-related anemia through suppression of bone marrow erythropoiesis and dyserythropoiesis.
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PMC11400680
Area in pixels of segmented cells and nuclei. (
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PMC8343815
Cell viability was examined in all cells exposed to different treatment procedures, utilizing the MTT assay .
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PMC11569208
The same study found that knockdown of PPP4C in macrophages increased IFN-β production and thus reduced VSV replication.
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PMC11655498
The transcription of Zp and Rp is also regulated by epigenetic modifications.
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PMC11788920
All cases are significantly different from the control (P< .01 for all cases).
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PMC8316344
The proteasome contains three different catalytically active sites on subunits proteasome 20S subunit beta 1 (PSMB1), subunits proteasome 20S subunit beta 2 (PSMB2), and PSMB5 of the 20S core pore .
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PMC11794847
We screened out the GPT2 gene based on log2FC (Fold Change) and P-value (Fig. S11A).
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PMC11026382
To further explore the pattern of epistasis across TYMS backgrounds, we simulated growth rates over a range of DHFR kcat and Km values in each TYMS background (Fig. 2f).
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PMC11718031
Glycosylation for Trastuzumab using shake flask cultures is expected to be sub-optimal due to the lack of proper process controls at this scale.
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PMC11627398
Our data showed that SLC31A1 and MTF1 exhibited a positive correlation with NK cells, suggesting that SLC31A1 and MTF1 may facilitate the progression of septic shock though activating NK cells; however, this hypothesis requires further investigation in future studies.
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PMC11713588
Compounds with better in vitro potency and stability were then further optimized through an iterative series of pharmacokinetic (PK), and pharmacodynamic (PD) assessments.
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PMC9429973
Phenotype analysis of CHD4-/- models showed DNA damage markers 53BP1 and PARP expression increases significantly, highlighting the role of CHD4 within the DDR.
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PMC10809689
The trend of glutamate concentration after treatment with galectin-9 in the THP-1 cell line was increasing in comparison to the PMA and control group.
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PMC10667689
The Kovats retention index was calculated according to the retention times of normal alkanes (C9–C24) with the same oven temperature program.
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PMC11806106
This cannot be attributed to its moderate affinity to the receptor, since it is between fentanyl and morphine.
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PMC11634794
Univariate logistic regression analysis revealed that categorical assessment of LAMP1 expression was associated with poor prognostic clinicopathological features as shown in Table 1 .
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PMC11477621
The crude product was purified by silica gel chromatography to give the black solid (48 mg, 16%).
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PMC11799978
NIH3T3 and 4T1 cells were cultured until 70–80% confluency.
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PMC7762347
To exclude unspecific binding, the rea-APC control (Miltenyi Biotec, Germany) was used.
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PMC9351137
Scale bar = 10 μm Localization of CRS to the mitotic apparatus The antibodies against the CRS of interest were validated by both IFM and Western blotting (WB) on HeLa cells transfected with a specific siRNA mix targeting the transcripts of each gene encoding the CRS (see “Methods”).
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PMC11347429
Influenza virus infections represent a major global health problem.
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PMC7841189
Tumor size was measured every 5 days using a caliper and calculated using the formula: volume = length × width × π/6.
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PMC10547921
Figure 23The mode pattern of dual-payloads drug ADC (The red and green shapes mean different payloads).Figure 23 The mode pattern of dual-payloads drug ADC (The red and green shapes mean different payloads).
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PMC11798926
Representative image of SynDIG4∆170–89 deletion mutant.
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PMC9429973
The safety profile of the triplet included rates of cytopenias similar to those observed with AZA+VEN; additional low-grade adverse events included infusion-related reactions, dyspnea, fatigue, gastrointestinal toxicities, electrolyte imbalances, and pneumonia.
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PMC9429973
One of 4 patients treated non-intensively achieved a CR.
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PMC7685376
MCM3/5 can inhibit the activity of MCM4/6/7 helicase, while MCM2 stabilizes the interaction between MCM3/5 and MCM4/6/7.23,24 In addition to participating in DNA replication, MCM proteins also play an important role in RNA transcription, chromatin reconstruction, and maintaining gene homeostasis.25,26 In the clinic, MC...
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PMC11766309
Preclinical studies targeting YKT6 in combination with ICIs or chemotherapies will be critical to translate these insights into clinical applications.33 Furthermore, structural studies designed with specific inhibitors or modulators of YKT6 could accelerate its development as a therapeutic target.
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PMC11541409
Providing evidence that antibody-drug conjugate is a possible drug format to overcome drug resistance for advanced GIST patients.
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PMC11549612
The exploration of BOLA1, BOLA2, and BOLA3 expression and its impact on molecular and immune subtypes of KIRC sheds light on the intricate interplay between BOLA family genes and the tumor microenvironment.
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PMC11139449
Specific locations in the CASP8AP2 gene’s 3’ untranslated region (3’UTR) were targeted using two donor vectors.
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PMC4485648
Moreover, these effects can be recapitulated in ovarian cancer cell variants A2780/ADR and A2780/CP resistant to adriamycin and cisplatin, respectively, suggesting that chemoresistance cannot abolish the SFN-mediated down-modulation of adaptive responses to hypoxia.
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PMC11792090
Consistently, upon co-culture with NK cells, the apoptotic rate of CD47 UCAR-T cells was lower than that of UCAR-T cells, suggesting that CD47, acting as an inhibitory ligand, reduced NK cell reactivity ( Figure 3E ).
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PMC9429973
Twenty-seven patients had a JAK2V617F mutation (mean allele burden, 72.19%).
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PMC5673955
P ≤ 0.05 versus cells cultivated with RrA. We measured the ratio of living, apoptotic, and dead cells by flow cytometry after removal of RrA from media.
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PMC11626627
The results showed that targeting sh-ERβ with oe-TWIST1 partially reversed the inhibition of ccRCC progression caused by ERβ shRNA (Fig. 6B, C). (
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PMC11247842
In addition to the clinical observation, the diagnosis “mastitis” was supported by considering the mean (and standard deviation) SCC until lactation day 150, and the occurrence of a milk sample with > 350,000 somatic cells.
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PMC11705067
The expressions of FDX1 and DLAT are tightly associated with immune checkpoints, including PD-1, LAG3, PD-L1 and TLR4.
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PMC11332076
Significance was determined using the non-parametric Kruskal-Wallis and post hoc Dunn's Multiple comparison tests.
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PMC11281366
Total RNAs (100 ng) were reversed transcribed using SuperScript IV reverse transcriptase (Invitrogen) with poly(dT) and specific loop primers (see Table S1) for the appropriate miRNAs using the two-tailed real-time qPCR method .
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PMC11429241
Two-dimensional cell cultures’ applicability to cancer research is limited due to a lack of specific cell–cell and cell–extracellular matrix (ECM) interactions, as well as the unlimited access to nutrients, oxygen, and metabolites, leading to altered gene and protein expression .
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PMC11737091
The experiment was carried out three times independently.
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PMC11742670
Machine learning (ML) and DL methods are employed in drug discovery and development.
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PMC11472639
Within the CD19CD20 B-cell population, B-cell subsets were identified by plotting CD38 against CD27, and confirmed as polyclonal through an Ig-Kappa × Ig-Lambda plot.
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PMC10891340
DEF was infected with 0.001 MOI of DPV-GFP for 1 h, treated with 10 μM and 20 μM CCCP, and incubated at 37°C for 36 h. The size of DPV-GFP fluorescent plaque was observed by using fluorescence microscopy.
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PMC11013014
The preparation of the pyridazino-1,3a,6a-triazapentalene (PyTAP) pharmacophores 19 and 20 was achieved according to procedures from the literature .
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PMC9429973
Out of the 116 patients, 46 (39.7%) patients passed away during ICU stay and 17 (14.7%) patients presented with thromboembolic events (2 of them with 2 TE).
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PMC9672323
Dexamethasone, a common medication used in the treatment regimen of glioblastoma, has broad inhibitory effects on the immune responses.
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PMC11218145
First, following the treatment with TB, we measured the mitochondrial and cytosolic Ca transients (as markers of the mitochondrial function) after agonist stimulation capable of inducing the Ca release from the endoplasmic reticulum (ER).
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PMC11180402
Western blot analysis of indicated proteins in cells with/without ISO treatment; GAPDH for normalization. (
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PMC9398137
B, Immunoprecipitation of BCL2 protein and Western blot analysis of proteins bound to BCL2 in UPF4D cell line with transgenic overexpression of BCL2 following exposure to S63845 (1 μmol/L, 3-hour incubation) compared with untreated cells (CTRL).
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PMC10938377
Penicillin streptomycin, RPMI 1640 GlutaMAX (where RPMI = Roswell Park Memorial Institute), and DMEM GlutaMAX media (where DMEM = Dulbecco's modified Eagle medium) were obtained from Life Technologies, and fetal bovine serum (FBS) was obtained from Sigma.
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PMC9429973
Aims: N/A Methods: Enrolled patients had primary or secondary MF with splenomegaly (DIPSS ≥ Intermediate-1) and did not receive prior therapy with JAK-2 or bromodomain and extraterminal motif (BET) inhibitors.
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PMC10198699
First, the provision does not make sense, as donation would not be donation without the transfer of ownership.
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PMC11640247
RAC-binding regions (RBRs) of human PAK1 (aa 67–150), human MLK2 (aa 401–550), and rat N-WASP (aa 191–270) were amplified from a cDNA pool of U251MG cells or rat brain and inserted into the pGS21a vector (GenScript, Piscataway, NJ, USA) .
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PMC11487720
A fascinating aspect is the role of cold shock in enhancing the UV-mediated NOS2 accumulation in the nucleus for NO production and bubble formation .
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PMC11476004
For the culture for the SCE assay, BrdU (5-bromodeoxyuridine) was added (10 µg/mL) after 24 h of the cell culture.
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PMC11678448
Transient leukopenia was observed between 6 to 12 h post-infection, followed by progressive leukocytosis from 24 to 60 h. Lymphopenia was noted in the total leukocyte count.
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PMC11344246
Interestingly, at 10 μM, RO-3306 did not have a significant effect on one MOC cell line, RMUG-S. Notably, RNA sequencing showed this cell line expressed >6-fold less CDK1 than the other two cell lines, highlighting the importance of screening targets across multiple molecularly diverse cell lines for heterogenous disea...
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PMC11718109
The pellet was scraped with a spatula from the bottom of the tube, resuspended in 100–200 μl of 120 mM PB buffer, and gently re-homogenized.
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PMC8270637
The expression of CTLA-4 on T cells was analyzed by flow cytometry. (
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PMC9429973
At median follow-up of 9.7 months (IQR, 7.2–12), 98.3% patients achieved overall platelet response; median time to first platelet response was 4 weeks (95%CI: 3–5).
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PMC9429973
Aims: As the production of microthrombi and endothelial damage is one of the complications due to SARS-CoV-2 infection we would evaluate several molecules linked to the NETosis process in patients infected during the first wave and compare them with levels in general population (pre-Covid) and patients during January 2...
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PMC9429973
Omipalisib had an inhibitory effect on the mitochondrial basal respiration rate and maximal respiration.
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PMC8469018
A constant flow rate of 1.0 mL/min was used for the separation.
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PMC11643491
Thermal stretching was performed on films with embedded fluorescent 0.8 um PS particles, which were preheated to 140 °C and then stretched while maintained at this temperature.
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PMC9424261
It was further analyzed that CA acts on MDM2 through HERPUD1, increases the ubiquitination of GSS, and then reduces the content of GSS to reduce the synthesis of GSH, thereby increasing the sensitivity of liver cancer cells to ferroptosis.
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PMC11653168
In summary, the longer treatment duration required for significant STAT3 inhibition in the present experiments highlights the context-dependent nature of STAT3 signaling and suggests that prolonged Stattic exposure might be necessary to achieve optimal therapeutic effects in T-ALL models.
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PMC11706491
Pcn1, RitC, and SynCut3 were generated by stable integration of plasmids pAV0607, pAY1035 and pAY1193.
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PMC11742290
LGR5 promotes WNT/β-catenin signaling pathway in brain, breast, cervical, colorectal, hepatic, gastric, and ovarian cancer.
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PMC11464982
In the long‐term treatment without S9‐mix, a statistically significant increase in structural chromosomal aberrations was seen only at the highest concentration tested (10,100 μg TOS/mL) associated with a high level of cytotoxicity (69%).
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PMC9429973
Informed consent to publish the case is obtained from patient.
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PMC11765243
These data show that T cell-specific p110α inactivation alters T cell differentiation and function.
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PMC9164404
B Semi-quantitative study of the intracellular uptake of Abplatin@Cy5.5 via flow cytometry.
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PMC11720107
The level of LDH release was measured on a 96-well plate after 24 h of incubation with garlic cultivar extracts (0.062, 0.125, 0.250, 0.500, and 1.000 mg/mL).
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PMC11257988
The conformation of KRAS protein cycles between two different conformational states.
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PMC11705862
As expected, no differences in SNARE complex formation between Syntaxin 1 and SNAP-25 were detected, which are both localized together at the plasma membrane (Fig. 3I, quantification in J).
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PMC11310713
In addition, we checked the estrous cycle daily during the last 2 weeks.
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PMC9429973
Safety analyses were performed on the safety population (N=332) and summarized using descriptive statistics.
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