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OTAR3088
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BioData-CellLine_annotated

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PMC11337594
Configure the matrix gel by referring to the instructions of Biozellen 3D Cell Culture Matrix Gel Kit (B-P-00003-4#, Biozellen, NE, USA).
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PMC9429973
Aims: To evaluate the the safety, tolerability, pharmacokinetics (PK) and preliminary activity of SC cevostamab monotherapy in patients with R/R MM.
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PMC9429973
Key players in this setting are the Hedgehog (Hh), Notch and WNT/β-Catenin pathways.
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PMC11707577
This aberrant morphology clearly indicates the tentacle cells as targets of M13EGFR(TNP) photoactivation.
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PMC11320834
Liposomes were extruded gradually using polycarbonate membranes with pore sizes of 200 nm (5 times) and 100 nm (6 times) at room temperature using an extruder device from Northern Lipids Inc. (Vancouver, BC, Canada).
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PMC8623816
The “volcano plot” and “MA plot” showed the distribution of the DEGs between strains D122 and D122-P (Figure 7).
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PMC9895440
For example, the genetic absence of PD-1 increases T cell exhaustion in mice, presumably due to overactivation.
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PMC11615743
The target cells (CEMs) were prestained with Hoechst 33 342.
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PMC9919300
Taken together, these data confirm that, after steatosis induction, the association reduced the LDs and TG accumulation by approximately 50%.
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PMC8633974
Nucleotide heterogeneity of 4004 annotated HIV-1 strains is depicted in a heat-map form demonstrating entropic (blue) or conserved (red) loci in three reading frames.
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PMC11544122
Data were analyzed by one-way ANOVA, followed by Dunnett’s multiple comparison test compared to Con.
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PMC8978939
We have demonstrated the pathogenicity of P138R and L163R novel variants, involving HIF-dependent and HIF-independent mechanisms.
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PMC9250505
D Patient-derived xenograft: confluent cultured cancer (5 × 10) cells from the patient’s ascites were injected subcutaneously into the flank of 5-week-old BALB/c athymic mice.
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PMC11738017
Circos plot of patient MM-19 based on WGS data.
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PMC11474209
It is also quick and extremely sensitive to identify MCs and provides toxicological data to secure the health of humans and animals .
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PMC11128598
The presence of mycoplasma was routinely checked using the MycoAlert kit (Lonza, Basel, Switzerland) and only mycoplasma-free cells were employed in the experiments.
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PMC11441402
Automated cell imaging was most accurate at measuring cell number in both adherent and suspension cell lines.
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PMC11637284
Commercially available antibodies were used as follows: monoclonal mouse anti-myc antibody (Invitrogen, 132500; IB 1:2’000, IF 1:50), monoclonal mouse anti-HA antibody (Enzo Life Sciences AG, CO-MMS-101 R-1000; IB 1:5’000).
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PMC11703992
Additionally, it also implies the avoiding of being exhausted of CD4+ Memory T cells in GCA progress.
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PMC11694346
Interestingly, the probe also responded to H2S, with a fluorescence intensity similar to that observed for Cys and Hcy.
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PMC11682525
, and 5 µl of Hoechst stock solution (2 mg.
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PMC11770130
We then tested whether the NTS-NTSR2 signaling regulated the production of GDF15 via controlling ceramide metabolism.
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PMC11628904
All experiments were performed with at least 3 independent biological replicates defined as either separate breeding clutches of zebrafish or human subjects, with the N‐value used for statistical analysis indicated within the relevant figure legend.
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PMC11676674
However, there are limited clinical and experimental data available regarding the safety of most herbal remedies.
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PMC11742864
Despite the improvement of various therapeutical options for lung cancer, cachexia is the leading contributor to death.
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PMC11758416
Gently transfer the cell solution from the microcentrifuge tubes to a 15 mL conical tube.
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PMC11087766
Percent of infected cells imaged in (B) that contained a phage nucleus > 0.5 µm (n = 121 to 182 infected cells per condition). ****
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PMC11055510
The number of clones in the ov-IL1RAP+mimics group was significantly lower than that in the ov-IL1RAP+mimics nc group (Fig. 7E).
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PMC9024365
The proline-rich domain may be important for interaction with other auxiliary factors or scaffolds necessary for trafficking and anchoring at synapses.
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PMC11772585
For multiple comparisons, a two-way ANOVA followed by Tukey’s post hoc test was conducted to determine statistical significance. *
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PMC11046454
Similarly, significant improvement on eradication of target cancer cells was obtained by incorporating both anti-EpCAM and anti-CD71 CAR-T with the TDN nanoscaffold (Figures S31 and S32).
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PMC6892818
Bars represent mean cytokine concentration (pg/ml) ± SEM for three technical replicates and are representative of two independent experiments.
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PMC11267036
In summary, this study revealed that DHM exerts therapeutic effects on MM by inhibiting viability, migration, invasion, EMT, and tumor growth, as well as enhancing apoptosis via STAT1/RIG-I activation.
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PMC11787355
j Cytotoxicity upon serial diluting CD8 T cells.
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PMC6742971
The data were analyzed with Prism software as previously described (3).
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PMC11486946
b Compounds reducing both EGFR mobility and clustering induce EGFR internalization.
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PMC10988555
Further clarification can be found below in the DFT calculations section.
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PMC8540692
In fact, the combination of CCM with NaBu increased the permeability of all three curcuminoids, including curcumin, demethoxycurcumin, and bisdemethoxycurcumin.
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PMC10976516
Four hypotheses might explain this lack of efficacy: (1) patients carry antiviral antibodies.
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PMC11672142
All pH measurements were performed using a Thermo Fisher Scientific Orion Star A211 and a StrataChemometer Orion 9157BNMD electrode.
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PMC10887351
The ligand–receptor binding induces a conformational change in the C-terminal tail of the receptor that couples with a G-protein with an exchange of guanosine diphosphate (GDP) with guanosine triphosphate (GTP) and separation of the G-proteins into active Gβγ and Gα subunits.
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PMC11777207
Murine or human CCL21 (Peprotech) were placed in the bottom well at a concentration of 1 μg/ml in a total volume of 500 μl of complete MEM (mouse) or RPMI 1640 (human).
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PMC9429973
All patients who were cyclin D1-positive according to immunohistochemistry were also assessed for rearrangements of the cyclin D1 gene (CCND1) using fluorescence in situ hybridization.
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PMC11095939
The results of western blotting and corresponding quantification in Mecp2-cKO livers indicated that Mecp2 depletion promoted quiescence exit in hepatocytes after PHx (Figure 2B).
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PMC11574271
Generation of stable bladder cancer cell lines overexpressing/down-expressing RON and their corresponding negative control variants: Lentiviral constructs containing specific sequences for overexpressing or silencing RON were from Genechem (Genechem, Shanghai, China).
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PMC11742231
Linking Technical Innovation to Clinical Impact: Ablation studies confirm the efficacy of the attention and fusion modules, contributing to more accurate predictions.
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PMC11434983
The two bands due to the PPh3 were observed at 691 cm and 743 cm.
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PMC11551844
The method is suitable for poorly water-soluble extracts and sterols.
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PMC10502403
Prior to extraction, T cells were cultured for 6 h in RPMI 1640-10% FCS medium with or without TCR stimulation.
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PMC6642070
p53 mRNA levels with fluvastatin (10 μΜ) treatment at the indicated time (left panel) and after HMGCR knocking down (right panel) in A-204 cells (n = 3). (
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PMC10734950
This assay was used to determine the phosphorylation status of MAPK and JAK-STAT membranes to gauge phosphorylation.
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PMC2118063
A t test was used to identify genes that distinguished each subset from all the others.
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PMC11738017
Calcein AM and propidium iodide were used to stain the cells to assess the target cell viabilities.
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PMC10847511
In conclusion, we analyzed molecular characteristics and drug screening data from the largest currently available cancer cell line library and found that differences in HRD status between cell lines do not correlate with sensitivity to platinum or PARP inhibitors in 2D cell culture assays.
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PMC6803987
Evaluation of the liver sections is mainly based on hepatocyte degeneration, necrosis and inflammatory cell infiltration.
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PMC11774747
CD30.CAR-EBVST have been tested in a Mixed Lymphocyte Reaction (MLR) co-cultured with allogeneic PBMC or primed alloreactive T cells (p-ART) to simulate an alloreactive immune response.
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PMC9429973
At Week 24, the median score for evaluable patients fell to 3 and dropped to a median of 1 at Week 48.
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PMC11126803
Data are presented as mean ± SD.
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PMC11525293
B p63-null U-2 OS cells were treated for 24 h with increasing concentrations of Thal (10, 50, 100 µM) or Len (1, 5, 15, 50, 80, 100 µM).
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PMC9910796
Next, a plasmid bearing appropriate flanking sequences for recombination was designed and synthesised in vitro (Genecust).
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PMC9429973
The scRNAseq of BM highlighted the elevated expression levels of inflammation response genes, including Cxcl9 and Cxcl10, and MHC classⅡ, together with the deceased expression of niche factors in niche cells in allo-SCT mice.
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PMC11700247
B-C) A20 tumor growth from irradiated and nonirradiated abscopal tumor as followed by caliper measurements (n = 5-6 mice). (
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PMC11686380
GAP43 is abundantly expressed in the nervous system, suggesting its essential role in neuronal function.
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PMC11656657
We further investigated the prevalence and intensity of GD2 expression in pediatric sarcomas, providing valuable insights into the potential feasibility of targeting GD2 with CAR T-cell immunotherapy.
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PMC2118063
To discover B cell genes regulated by IRF8, we transfected purified primary tonsillar B cells with enhanced green fluorescent protein–tagged IRF8, generated small interfering RNA knockdowns of IRF8 expression in a mouse B cell lymphoma cell line, and examined the effects of a null mutation of IRF8 on B cells.
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PMC6114978
For MST1(STK4) the BAC utilized was RP11-844G5 (195 kb), for MST2(STK3) the BACs utilized were RP11-208K6 (167 kb), RP11-825F16 (187 kb), and RP11-159A16 (213 kb), for LATS1 the BAC utilized was RP11-69I17 (159 kb), for LATS2 the BAC utilized was RP11-45A5 (154 kb) and RP11-22J15 (202 kb).
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PMC11790599
This selective cytotoxicity is linked to the induction of methuosis via NRF2 activation.
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PMC11489175
USP1 contribution to the aggressive feature of ovarian cancer has been dissected out 80 and inhibitors of this DUB are being developed.
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PMC7840816
To the best of our knowledge, the current study represents the first demonstration that SOX9 was upregulated in PTC.
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PMC3813807
In addition, miR-373 was noted to affect esophageal cancer cell growth through the inhibition of LATS2 expression (12).
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PMC7553912
Scale bars = 100 μm.
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PMC10747160
The gene encoding for Monomeric Griffithsin protein (with a 1GS insertion at positions 18 and 19, and the Leucine at position 2 substituted for a Serine) with an N-terminal 6xHis tag was inserted into the pET28b vector between the NcoI and XhoI restriction sites (again from Twist Bioscience).
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PMC10125312
With this systematic study, we demonstrate the safety and efficacy of PPTT in an in vitro setup, highlighting the importance of creating reliable, reproducible, and meaningful data sets that are comparable between studies and groups that use different types of nanoparticles or laser irradiation.
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PMC11365983
D–F) Foxc1 overexpression induced comparable reductions in total Pdgfrα, and pY754-Pdgfrα levels, indicative of impaired cilia-mediated Pdgf signaling (n = 3). [
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PMC9429973
Allele and genotype frequency results were compared to those described in the Italian population by Uboldi de Capei et al. (2003) and Poli et al. (2002).
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PMC11791264
Ubiquitylation of LC3B, a common isoform of LC3, at lysine 51 (K51) by the ubiquitin ligase BIRC6 triggers its proteasome-mediated degradation (3).
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PMC11730311
Experiments were performed in singlicates.
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PMC6024716
A peculiar phenomenon is that although both knockout cell lines have higher intracellular polyamine concentrations than the parental cell line, the observed relationship between polyamine concentration and recombinant protein expression is not proportional.
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PMC10936243
Figure 1.Diagram of the explanatory sequential mixed-methods design as adapted for the current experiment (Creswell et al. 2003).
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PMC7823217
Hakobyan et al. developed 3D pancreatic cell spheroid platforms employing laser-assisted bioprinting and exemplified their morphological changes over time through image analysis and phenotypic characterization .
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PMC11545868
Cytochrome c resides between the mitochondrial membranes and is released into the cytoplasm, nucleus, and extracellular space in response to certain stimuli.
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PMC9325715
Thus, the synthesis of the Fe-bLTF complex for further investigations was performed with the utilization of Fe solution with a concentration of 600 mg/L. The excess of the iron was utilized to obtain complex with fully filled monolayer and with maximum yield.
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PMC9429973
At 44.0 mo median follow-up (range 0–88.0), median PFS was 38.6 mo and 46.9 mo and PFS rates at 36 mo were 54% and 65% in pts with del(17p)/TP53m and uIGHV, respectively (Fig 1C).
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PMC10452486
Spontaneous arthritis occurs in HLA-B27+ mice lacking B2m (HLA-B27+ B2m−/−) but not in HLA-B27+ B2m+/− mice.
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PMC8984067
3·5H2O (99.9%), Yb(NO3)3·5H2O (99.9%), Y(NO3)3·6H2O (99.9%), NaOH (analytical purity AR), absolute ethanol (AR), hydroxyethyl cellulose (AR, viscosity of 20,000 mPa s), polyethyleneimine (PEI, M.W. = 10000, 99%), NH4F (98%), concentrated hydrochloric acid (AR, 37%), dimethyl sulfoxide (DMSO, AR), 1-(3-dimethylamino pro...
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5673060
The screen also showed that the dual mTOR/PI3K inhibitor BEZ-235 sensitized both DasR and PazR which recapitulates the findings of a recent report on the use of this drug to overcome pazopanib resistance in patient-derived soft tissue sarcoma cells .
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PMC11075223
Through formalin-induced pain response, hot-plate test, acetic acid writhing test, the analgesic and sedative activities of honey-processed C. dahurica and C. foetida were significantly stronger than those of raw production .
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PMC11513011
DIB was dissolved in dimethyl sulfoxide (DMSO) and used in the experiment.
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PMC11680982
MicroRNA sequencing (F) revealed the effect of neratinib on miRNA changes, and compared with CDK4/6 inhibitor + endocrine therapy group, the triple combination treatment group administered neratinib, CDK4/6 inhibitor, and endocrine therapy had significantly upregulated hsa-miR-23a-5p (G), which highly interacted with H...
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721064
p < 0.05, **p < 0.01, ***p < 0.001 LNCs facilitate the transdifferentiation of KPCs towards corneal epithelial cells via the STAT3 signaling pathway.
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PMC8633974
Z-stack analysis was performed to show that the TatDE LNPs were indeed inside the nucleus, not on top in a different plane.
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PMC9429973
Key secondary endpoints included overall response rate (ORR), depth of response, survival and safety.
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PMC9429973
Patients may receive up to 13 cycles unless there is disease progression or unacceptable toxicity.
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PMC11711127
However elsewhere, anti-CD3 and ICAM-1 loaded bilayers confer stable synapses with human Tregs with a notable dislocation of PKC-θ away from the contact, which is otherwise a key component of the signalling machinery in effector T cell synapses (138).
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PMC9429973
Aims: To investigate the efficacy of Zanubrutinib combined with immunochemotherapy in pts with CD79A/CD79B-mutant DLBCL.
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PMC6468656
Increasing reports point out ghrelin’s role in cancer progression.
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PMC10938377
High resolution electrospray ionization mass spectra (HR ESI-MS) were obtained on a Xevo G2-S QTOF mass spectrometer coupled to the Acquity UPLC Class Binary Solvent manager and BTN sample manager (Waters, Corporation, Milford, MA).
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PMC9164404
Cisplatin could bind with DNA to form adducts, thereby affecting DNA replication and killing cancer cells .
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PMC8389560
At the same time, mitochondrial overload with Ca ions and the opening of mitochondrial permeability transition pores (PTP) can occur, also causing apoptosis .
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PMC9429973
These mutations cause a reduced (β+) or absent (β0) production of the β-globin chain.
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