OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC6267596	Here, we investigated the molecular and cellular processes and signaling pathways of therapy failure due to DIAP in DH/DE-DLBCL and to discover novel therapeutic targets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11718109	Scale bars, 10 μm for fluorescence images.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", ",", "10", "μm", "for", "fluorescence", "images", "." ] } ]
PMC11216402	In contrast, the Epi-like cell lines and TCGA-STAD ATAC-seq were more correlated with the primary stomach.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",", "the", "Epi-like", "c...
PMC9429973	QUIZ (30 or 40 mg/day) was administered daily continuously.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "QUIZ", "(", "30", "or", "40", "mg/day", ")", "was", "administered", "daily", "c...
PMC11098378	We next sought to determine if SHOC2 and PSMC1 were targeted by IpaH4 in the insect cell background.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "next", "sought", "to", "determin...
PMC6901583	c Representative IHC staining of BRD4 and CD31 in the two groups is presented.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "c", "Representative", "IHC", "staining", "of", "BRD4", "and", "C...
PMC11711127	These include extrinsic and intrinsic apoptosis, necroptosis and ferroptosis, among others.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "include", "extrinsic", "and", "intrinsic", "apoptosis", ",", "necr...
PMC11487720	In controls, ectopic monomeric DsRedM had no effect By co-immunoprecipitation, UV/cold shock induced the dissociation of the endogenous WWOX/TRAF2 complex in 30 min in COS7 cells (Fig. 7D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellL...
PMC11604768	Individual sample read depth factors were calculated by scaling the upper quartile of raw read counts to that of an arbitrarily chosen reference sample (upper quantile read counts/ reference sample upper quartile read counts).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11395280	While we observed no effect of CCL198-83 on β1-integrin-mediated adhesion, we did find that the antagonist blocked β2 integrin-mediated transmigration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While",...
PMC11786767	The peaks of PS and Ki-67 signals at the chromosome edge are set as 0.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "peaks", "of", "PS", "and", "Ki-67", "signals", ...
PMC11522251	Of course there are still many shortcomings in this study, such as the specific mechanism of HOXB8-mediated STAT3 phosphorylation was not thoroughly investigated, and animal experiments were not carried out for validation, etc.,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11551844	AuNPs could be internalized in cells by either receptor-mediated endocytosis, or non-specific receptor independent endocytosis depending on the shape, size, surface charge and functionalization of the AuNPs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5963610	In the case of 4T1-model 40% of the mice remained alive (but not tumor free), in the combination group.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10454535	At 72 h, the IC50 values for each of the RES derivatives were approximately 13 μM while the value for BTZ was around 2 nM (Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9386809	When the reaction was carried out in EtOH, a substantial increase in the yield (66%) of compound 3a was noticed (Table 1, entry 6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11634794	Knockdown of the LC3C gene resulted in reduced levels of LAMP1 expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Knockdown", "of", "the", "LC3C", "gene", "resulted", "in", "reduced", "levels", ...
PMC10142392	PCL has also been used in implantable devices for the sustained administration of various drugs such as antibiotics; antipsychotics; antiplatelet agents, namely dipyridamole and acetylsalicylic acid; nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen; or even thyroid hormones such as levothyroxine.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9250505	Human (h) BAD is primarily phosphorylated at Serine (S)75 through p44/42 MAP kinase pathway activation, and at S99 through activation of AKT/p70S6K.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9024365	Furthermore, we observed a significant increase in the mean area of GluA1 clusters co-localized with SD4 after glycine induced chemical-LTP (Figure 8C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC6182045	Proteins were additionally assayed for Endo H sensitivity to evaluate for presence of simple oligo-mannose terminal glycans, or complex sialic acid containing carbohydrates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC8623816	Then, categorization and expression statistics of Cufflinks predicted transcripts with variable splicing events using ASprofile (V1.0.4) software.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "categorization"...
PMC10547921	The payload for ADCs needs to contain active heteroatoms to bind the cleavable linker, while FK-866 lacks an amino, hydroxy, or mercapto functional group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8750422	As expected, L-NAME treatment markedly abolished the effects of GPR87 overexpression (Figure 4g and Figure S4g).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "expected", ...
PMC9429973	Image: Summary/Conclusion: We established the in vivo and in vitro models for MM with the technology of MET/MENK which can be used not only for mechanism research but also for the therapy evaluation, such as CAR-NK and CAR-T. Y. Lan, H. Mei, L. Tingting, Y. Hua, W. Qiuling Institute of Hematology, Union Hospital, Tongj...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11454015	M. Musick: None.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "M.", "Musick", ":", "None", "." ] } ]
PMC9964635	HNMR (400 MHz, CDCl3) δ 11.77 (s, 1H, SH), 7.05 (d, 2H, J = 8.0 Hz), 6.99 (d, 2H, J = 8.0 Hz), 3.96 (q, 1H), 3.18 (s, 3H), 2.39 (d, 2H, J = 8.0 Hz), 1.80 (m,1H), 1.62 (d, 3H, J = 8.0 Hz), 0.83 (d, 6H, J = 8.0 Hz).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11085211	Interestingly, in the first gross investigation by flow cytometry, a further cell population with a lower cell size index and a slight increase in viability staining was observed in AUN-treated GIST-882 compared to the control (Supplementary Figure S1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3675084	The observations are consistent with reports that decreased expression of cyclin B1 and BubR1 is associated with weakened spindle checkpoint and paclitaxel resistance in ovarian carcinoma cells ; depletion of BubR1 with siRNA resulted in loss of spindle assembly checkpoint function and resistance to paclitaxel .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLin...
PMC11682224	VEGF (vascular endothelial growth factor) is a potent angiogenic factor that provides sufficient oxygen and nutrients to the tumour by stimulating the formation of new blood vessels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767793	The mass ratio of PEI to Au in the Au-PEI conjugate was equal to 5.60 ± 0.24 (one standard deviation), which corresponded to a PEI/Au molar ratio of 24.7 (calculated using 42 as the unit molar mass of PEI) in the Au-PEI@NIST.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10728200	The red dots indicate the positive PLA signal.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "red", "dots", "indicate", "the", "positive", "PLA", "signal", "." ] } ]
PMC11502327	Cyclin, cyclin-dependent kinase (CDK) and CDK inhibitors are the core substances that regulate the cell cycle.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cyclin", ",", "cyclin-dependent", ...
PMC6803987	The leaves and stems of Microsorium fortunei (40.0 kg) were collected in Guangxi Resources County of Guangxi Province, China, in 2015, and esculetin was identified by Prof. Yunqiu Li, College of Pharmacy, Guilin Medical University.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	MDSC secreted cytokines IL-6, IL-10, IL-1β are the dominant constituent in regulating expression of multidrug-resistance pump by modulating STAT3, STAT1 and NF-κβ signalling axis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11604015	Since fratricide is caused by the interaction between antigens and CARs, one strategy to avoid fratricide is to reduce the expression of surface target antigens.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11506670	Luminescence was read at 490 nm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Luminescence", "was", "read", "at", "490", "nm", "." ] } ]
PMC9503669	Interaction kinetics of each analog with Nef was assessed in vitro using SPR along with a cell-based assay for antiretroviral activity (TZM-bl reporter cell assay for infectivity described above).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", ...
PMC11725127	The protein levels of KRAS, p-ERK, and β-actin were detected by western blotting with the indicated antibodies (A, C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11021472	The pcZDHHC11 and lncZDHHC11 transcripts showed a predominantly nuclear localization with more than 90% of the transcripts residing in the nucleus (Fig. 1B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	On validated psychological instruments, 52% of patients reported mild-to-severe depression (Patient Health Questionnaire [PHQ-9]) and 53% reported mild-to-severe anxiety (Generalized Anxiety Disorder Questionnaire [GAD-7]), over the previous 2 weeks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9712534	The mobile fractions were estimated to be 0.86 ± 0.05 (DMSO) and 0.86 ± 0.04 (ICRF).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mobile", "fractions",...
PMC9429973	Aims: Our study aims to evaluate the clinical characteristics, treatment patterns, as well as therapeutic results in patients with refractory/ relapsed HL (R/R HL) in a Tunisian center.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9960565	The dispersity studies revealed two distinct distribution types for pristine dendrimers and metallodendrimers with cisplatin conjugated in a monodentate form.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "dispersity", "studies...
PMC3888431	In contrast, the reference CHO-K1 genome is haploid so that allelic reads will map to the same genomic locus.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",...
PMC11637820	Collectively, our data report the first clinical relevance of CAP in eliminating bacterial pathogens in DFU ex vivo in the Southern Indian population.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11345828	Guo et al. have shown that disruption of cardiomyocyte function by siRNA is time dependent, with no change in contractile function observed 3 days post transfection, but a progressive reduction in beat amplitude and increase in beat rate on days 14 and 33.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11632064	Strikingly, BI-D1870 and BI 6727 have similar pro-inflammatory effects in MeWo cells, but they are, respectively, anti-inflammatory and proapoptotic in A-375 cells (Figs 1D and 4A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "...
PMC11790599	Therefore, the various indicators predicted by computer virtualization indicate that TSL has good drug potential.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "the", "various", "indicators", "pred...
PMC9429973	Treatment-emergent AEs (any grade [G]) in >50% of pts were CRS (70%), thrombocytopenia (70%), neutropenia (56%), anemia (52%), and infections (52%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11093197	MCF10A cells were purchased from ATCC, and Human Mammary Epithelial Cells (HMEC) were purchased from Thermo Fisher Scientific (A10565).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Compared to comparators, patients had increased rates of non-melanoma skin cancer (IRR 3.47 [2.18;5.38]) and myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML) (IRR 35.32 [15.73; 94.26]) (Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11540664	The results of our association analysis showed that patients with low peripheral blood lymphocytes are often accompanied by a decrease in platelets and leukocytes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10891340	As we known the accumulation of ROS leads to the occurrence of apoptosis in the mitochondrial pathway, we examined the effect of CCCP treatment on apoptosis under DPV infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8750422	Moreover, the level of intracellular NO in GPR87-overexpressing A549 cells further increased the effect of LPA treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "the", "level", ...
PMC10547921	After an ADC drug enters the blood circulation and binds to the target antigen receptor on the surface of the tumor cell, the newly formed ADC‒antigen complex will be degraded by lysosomes after internalization, releasing the payload and inducing the tumor cell death (Fig. 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11401358	In addition, SF can also effectively clear excess ROS in the bone marrow mesenchymal stem cells (BMSCs) stimulated by H2O2 in Fig. S5.Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11541241	Furthermore, the second‐generation TOR inhibitors show more drastic inhibitory effects compared with RAP in P. infestans and U. maydis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "the", ...
PMC9429973	To investigate whether SETD2/H3K36me3 loss impinges on the activation and proficiency of HR, we used UV rays to induce DNA damage in SETD2 siRNA-depleted LAMA 84 (SETD2-proficient) cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7724160	These empty cells are considered below the limit of detection but their true value is non-zero.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "empty", "cells", "are", "considered", "below"...
PMC11644761	Pterostilbene, found in blueberries, grapes, and grapevines, is a structural analogue of resveratrol and shares many of its properties, including anti-tumor, anti-inflammatory, antioxidant, anti-aging, and anti-obesity effects .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767725	Additional relevant studies were identified through manual reviews of reference lists from selected articles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additional", "relevant", "studies", "were", "identified", "through", "...
PMC11742290	Depending on different TMEs, LGR5 may promote metastasis or activate tumor-suppressive pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Depending", "on", "different", "TMEs", ",", "LGR5", "may", "promote", ...
PMC11621565	An efficient neuroprotective treatment does not yet exist due to the unresolved puzzle that is the biomolecular picture of PD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "efficient", "neuroprot...
PMC11271278	One amplicon is predicted to be a MYC-ERBB2 chimeric ecDNA, similar to what we report in NCIH2170 cells (Fig. S8B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11185260	In contrast, combining radiation and scL-vec did not increase the antitumor response compared with radiation treatment alone.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",", "combining", "ra...
PMC11532793	sleuth normalizes counts using sample-specific median-ratio size factors (18) followed by a started log-transformation to ensure positivity and normality.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "sleuth", "normalizes", ...
PMC11665584	Xenium illustrated that PITX1 skin had higher expression of pro-inflammatory genes S100a8 and Il1b in and around the neutrophil-laden areas, with the neutrophils themselves significantly enriched for expression of these markers (Figure 4C and Supplemental Figure 8C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5941560	Among the nonsynonymous mutations, 252 variants are nonsense mutations and 10,732 variants are missense mutations. ‘	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "the", "nonsynonymous", "mutations", ",",...
PMC11046454	As a proof-of-concept, we exploited the elevated ATP level within the TME and developed an ATP-responsive PTK7-targeting aptamer (ATP-AptPTK7), in which the two ends of AptPTK7 were extended with a split anti-ATP aptamer (Figure 4A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The 2 pts who achieved MLFS and PR died due to PD and fungal pneumonia after 5 and 1.5 months of starting therapy, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11627133	N=3 independent experiments) of K D=77±7 nM and K D=56±6 nM, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "N=3", "independent", "experiments", ")", "of", "K", "D=77±7", "n...
PMC11462673	B Western blotting analysis showed that LDB1 and GAPDH protein pression in Jurkat, 6 T-CEM and J.gamma1 cells after LDB1 knockdown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O" ...
PMC10578720	To determine whether DCA causes hepatotoxic effects, we compared ALT and AST levels between vehicle-treated and DCA-treated rAAV-1.3 HBV mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "determine", ...
PMC11531744	The immune-related genes were downloaded from GSEA database (http://www.gsea-msigdb.org/gsea/index.jsp).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "immune-related", "genes", "were", "downloaded", "from", "GSEA", "database", "(", ...
PMC11711663	GLDM LargeDependence HighGrayLevel Emphasis 9.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "GLDM", "LargeDependence", "HighGrayLevel", "Emphasis", "9", "." ] } ]
PMC9429973	After phlebotomy, there was a significant improvement in his pruritus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "phlebotomy", ",", "there", "was", "a", "significant", "improvement", "in", "...
PMC9503541	Medicinal plants with a long history of ethnopharmacological use have been a valuable source of effective phytochemicals that provide beneficial effects against numerous diseases .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10079526	Similar results were obtained in U2OS cells (Supplementary Fig. 1C, D).	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similar", "results", "were", "obtained", "in", "U2OS", "cells...
PMC10831439	Therefore, part of the effector cells was restimulated with modified target cells every 7 days, while the other part was challenged for 24 hours with PD-L1/2+ cells (figure 3D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11674146	CDH2 is a member of the cadherin family that regulates a variety of cellular processes like apoptosis, angiogenesis and chemoresistance and plays a profound role in the EMT (Gao et al., 2018).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10874773	They found that the potent inhibitory effects of anisatin and (1S)-minwanenone (6) on NCI-H460 and SMMC-7721 cells were comparable to that of 5-FU (Yin, Wang, Wang, & Kong, 2012).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "...
PMC11711063	Treatments were repeated every 48 h. After 5 days, cells were fixed in 4% formaldehyde and stained with DAPI, HCS‐CellMask‐Red and Phalloidin‐A488.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11781181	FTH1 was another novel miR-375-3p target in keratinocyte.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FTH1", "was", "another", "novel", "miR-375", "-", "3p", "target", "in", "keratinocyte", "....
PMC11657695	They form tetramers of α subunits to be active, and these subunits consist of six transmembrane segments and a pore domain.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "form...
PMC9429973	A positive correlation noted between the duration of stay and age of patient (P value 0.05) with a negative correlation between the stay and lymphocyte count (P value -0.024).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11638255	Neuroblastomas harbor an immunosuppressive tumor microenvironment and therefore combination strategies are now considered more likely to succeed in the restoration of antitumor immunity required for response to anti-GD2 therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11461833	E,F) Heatmap of SASP related genes and SASP pathway genes that were differentially expressed between empty vector-overexpressing and STXBP5 overexpressing HA-progerin-expressing HEK293 cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", ...
PMC5415764	Accordingly, the coadministration of P-gp inhibitors with anticancer drugs could efficiently overcome efflux-mediated drug resistance3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Accordingly", ",", "the", "coadministration", "of", "P...
PMC11733919	Hydrodynamic sizes slightly increased when adding the different components of the nanoplatform, which could be indicative of a successful functionalization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hydrodynamic", "sizes",...
PMC11757131	This finding is consistent with that of previous research on mice (21).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "finding", "is", "consistent", "with", "that", "of", "pre...
PMC11792766	No. N4638) was obtained from Sigma Aldrich.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No.", "N4638", ")", "was", "obtained", "from", "Sigma", "Aldrich", "." ] } ]
PMC11699465	Statistical analysis was performed using Student’s t-test except specific marked and expressed as median with Standard deviation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "analysis", "was", "performed"...
PMC11612794	There are two binding regions for Mis12C (binding regions 1 and 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "are", "two", "binding", "regions", "for", "Mis12C", "("...
PMC11188874	Cells were then analyzed on an Attune NxT and quantified using Flow Jo version 10.9.0.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "then", "analyzed", "on", "an", "Attune", ...
PMC11092382	Zhu et al. used β-amyloid to induce PC12 neuronal cell damage and evaluated the protective effect of sophocarpine.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Zhu", "et", "al.", "used", "β...
PMC9429973	Image: Summary/Conclusion: In this pilot study, we found that rivaroxaban was safe and well-tolerated as the primary preventive measure for venous thromboembolism in patients with multiple myeloma receiving lenalidomide-based regimen.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11525293	At 30 h post-infection, cells were washed with PBS, fixed with 4% formaldehyde in PBS for 10 min at room temperature, incubated for 10 min with the reagent containing 4,6-diamidino-2-phenylindole (DAPI), and washed again with PBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11371747	Data were expressed as mean ± SEM and analyzed by a t-test, Pearson correlation or two-way analysis of variance (2-way ANOVA) by GraphPad Prism software, version 5.1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11697703	Fezf2 controls multiple aspects of corticofugal neuron identity, including the use of glutamate as neurotransmitter, axonal projection via regulation of guidance molecules such as ephrin-B receptor 1 (EphB1), and is required for normal dendritic morphology.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6267596

Here, we investigated the molecular and cellular processes and signaling pathways of therapy failure due to DIAP in DH/DE-DLBCL and to discover novel therapeutic targets.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11718109

Scale bars, 10 μm for fluorescence images.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", ",", "10", "μm", "for", "fluorescence", "images", "." ] } ]

PMC11216402

In contrast, the Epi-like cell lines and TCGA-STAD ATAC-seq were more correlated with the primary stomach.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",", "the", "Epi-like", "c...

PMC9429973

QUIZ (30 or 40 mg/day) was administered daily continuously.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "QUIZ", "(", "30", "or", "40", "mg/day", ")", "was", "administered", "daily", "c...

PMC11098378

We next sought to determine if SHOC2 and PSMC1 were targeted by IpaH4 in the insect cell background.

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PMC6901583

c Representative IHC staining of BRD4 and CD31 in the two groups is presented.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "c", "Representative", "IHC", "staining", "of", "BRD4", "and", "C...

PMC11711127

These include extrinsic and intrinsic apoptosis, necroptosis and ferroptosis, among others.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "include", "extrinsic", "and", "intrinsic", "apoptosis", ",", "necr...

PMC11487720

In controls, ectopic monomeric DsRedM had no effect By co-immunoprecipitation, UV/cold shock induced the dissociation of the endogenous WWOX/TRAF2 complex in 30 min in COS7 cells (Fig. 7D).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellL...

PMC11604768

Individual sample read depth factors were calculated by scaling the upper quartile of raw read counts to that of an arbitrarily chosen reference sample (upper quantile read counts/ reference sample upper quartile read counts).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11395280

While we observed no effect of CCL198-83 on β1-integrin-mediated adhesion, we did find that the antagonist blocked β2 integrin-mediated transmigration.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While",...

PMC11786767

The peaks of PS and Ki-67 signals at the chromosome edge are set as 0.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "peaks", "of", "PS", "and", "Ki-67", "signals", ...

PMC11522251

Of course there are still many shortcomings in this study, such as the specific mechanism of HOXB8-mediated STAT3 phosphorylation was not thoroughly investigated, and animal experiments were not carried out for validation, etc.,

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11551844

AuNPs could be internalized in cells by either receptor-mediated endocytosis, or non-specific receptor independent endocytosis depending on the shape, size, surface charge and functionalization of the AuNPs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC5963610

In the case of 4T1-model 40% of the mice remained alive (but not tumor free), in the combination group.

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PMC10454535

At 72 h, the IC50 values for each of the RES derivatives were approximately 13 μM while the value for BTZ was around 2 nM (Table 1).

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PMC9386809

When the reaction was carried out in EtOH, a substantial increase in the yield (66%) of compound 3a was noticed (Table 1, entry 6).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11634794

Knockdown of the LC3C gene resulted in reduced levels of LAMP1 expression.

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PMC10142392

PCL has also been used in implantable devices for the sustained administration of various drugs such as antibiotics; antipsychotics; antiplatelet agents, namely dipyridamole and acetylsalicylic acid; nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen; or even thyroid hormones such as levothyroxine.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9250505

Human (h) BAD is primarily phosphorylated at Serine (S)75 through p44/42 MAP kinase pathway activation, and at S99 through activation of AKT/p70S6K.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC9024365

Furthermore, we observed a significant increase in the mean area of GluA1 clusters co-localized with SD4 after glycine induced chemical-LTP (Figure 8C).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC6182045

Proteins were additionally assayed for Endo H sensitivity to evaluate for presence of simple oligo-mannose terminal glycans, or complex sialic acid containing carbohydrates.

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PMC8623816

Then, categorization and expression statistics of Cufflinks predicted transcripts with variable splicing events using ASprofile (V1.0.4) software.

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PMC10547921

The payload for ADCs needs to contain active heteroatoms to bind the cleavable linker, while FK-866 lacks an amino, hydroxy, or mercapto functional group.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8750422

As expected, L-NAME treatment markedly abolished the effects of GPR87 overexpression (Figure 4g and Figure S4g).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "expected", ...

PMC9429973

Image: Summary/Conclusion: We established the in vivo and in vitro models for MM with the technology of MET/MENK which can be used not only for mechanism research but also for the therapy evaluation, such as CAR-NK and CAR-T. Y. Lan, H. Mei, L. Tingting, Y. Hua, W. Qiuling Institute of Hematology, Union Hospital, Tongj...

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PMC11454015

M. Musick: None.

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PMC9964635

HNMR (400 MHz, CDCl3) δ 11.77 (s, 1H, SH), 7.05 (d, 2H, J = 8.0 Hz), 6.99 (d, 2H, J = 8.0 Hz), 3.96 (q, 1H), 3.18 (s, 3H), 2.39 (d, 2H, J = 8.0 Hz), 1.80 (m,1H), 1.62 (d, 3H, J = 8.0 Hz), 0.83 (d, 6H, J = 8.0 Hz).

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PMC11085211

Interestingly, in the first gross investigation by flow cytometry, a further cell population with a lower cell size index and a slight increase in viability staining was observed in AUN-treated GIST-882 compared to the control (Supplementary Figure S1).

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PMC3675084

The observations are consistent with reports that decreased expression of cyclin B1 and BubR1 is associated with weakened spindle checkpoint and paclitaxel resistance in ovarian carcinoma cells ; depletion of BubR1 with siRNA resulted in loss of spindle assembly checkpoint function and resistance to paclitaxel .

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PMC11682224

VEGF (vascular endothelial growth factor) is a potent angiogenic factor that provides sufficient oxygen and nutrients to the tumour by stimulating the formation of new blood vessels.

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PMC11767793

The mass ratio of PEI to Au in the Au-PEI conjugate was equal to 5.60 ± 0.24 (one standard deviation), which corresponded to a PEI/Au molar ratio of 24.7 (calculated using 42 as the unit molar mass of PEI) in the Au-PEI@NIST.

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PMC10728200

The red dots indicate the positive PLA signal.

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PMC11502327

Cyclin, cyclin-dependent kinase (CDK) and CDK inhibitors are the core substances that regulate the cell cycle.

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PMC6803987

The leaves and stems of Microsorium fortunei (40.0 kg) were collected in Guangxi Resources County of Guangxi Province, China, in 2015, and esculetin was identified by Prof. Yunqiu Li, College of Pharmacy, Guilin Medical University.

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PMC9429973

MDSC secreted cytokines IL-6, IL-10, IL-1β are the dominant constituent in regulating expression of multidrug-resistance pump by modulating STAT3, STAT1 and NF-κβ signalling axis.

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PMC11604015

Since fratricide is caused by the interaction between antigens and CARs, one strategy to avoid fratricide is to reduce the expression of surface target antigens.

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PMC11506670

Luminescence was read at 490 nm.

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PMC9503669

Interaction kinetics of each analog with Nef was assessed in vitro using SPR along with a cell-based assay for antiretroviral activity (TZM-bl reporter cell assay for infectivity described above).

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PMC11725127

The protein levels of KRAS, p-ERK, and β-actin were detected by western blotting with the indicated antibodies (A, C).

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PMC11021472

The pcZDHHC11 and lncZDHHC11 transcripts showed a predominantly nuclear localization with more than 90% of the transcripts residing in the nucleus (Fig. 1B).

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PMC9429973

On validated psychological instruments, 52% of patients reported mild-to-severe depression (Patient Health Questionnaire [PHQ-9]) and 53% reported mild-to-severe anxiety (Generalized Anxiety Disorder Questionnaire [GAD-7]), over the previous 2 weeks.

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PMC9712534

The mobile fractions were estimated to be 0.86 ± 0.05 (DMSO) and 0.86 ± 0.04 (ICRF).

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PMC9429973

Aims: Our study aims to evaluate the clinical characteristics, treatment patterns, as well as therapeutic results in patients with refractory/ relapsed HL (R/R HL) in a Tunisian center.

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PMC9960565

The dispersity studies revealed two distinct distribution types for pristine dendrimers and metallodendrimers with cisplatin conjugated in a monodentate form.

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PMC3888431

In contrast, the reference CHO-K1 genome is haploid so that allelic reads will map to the same genomic locus.

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PMC11637820

Collectively, our data report the first clinical relevance of CAP in eliminating bacterial pathogens in DFU ex vivo in the Southern Indian population.

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PMC11345828

Guo et al. have shown that disruption of cardiomyocyte function by siRNA is time dependent, with no change in contractile function observed 3 days post transfection, but a progressive reduction in beat amplitude and increase in beat rate on days 14 and 33.

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PMC11632064

Strikingly, BI-D1870 and BI 6727 have similar pro-inflammatory effects in MeWo cells, but they are, respectively, anti-inflammatory and proapoptotic in A-375 cells (Figs 1D and 4A).

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PMC11790599

Therefore, the various indicators predicted by computer virtualization indicate that TSL has good drug potential.

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PMC9429973

Treatment-emergent AEs (any grade [G]) in >50% of pts were CRS (70%), thrombocytopenia (70%), neutropenia (56%), anemia (52%), and infections (52%).

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PMC11093197

MCF10A cells were purchased from ATCC, and Human Mammary Epithelial Cells (HMEC) were purchased from Thermo Fisher Scientific (A10565).

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PMC9429973

Compared to comparators, patients had increased rates of non-melanoma skin cancer (IRR 3.47 [2.18;5.38]) and myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML) (IRR 35.32 [15.73; 94.26]) (Table 1).

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PMC11540664

The results of our association analysis showed that patients with low peripheral blood lymphocytes are often accompanied by a decrease in platelets and leukocytes.

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PMC10891340

As we known the accumulation of ROS leads to the occurrence of apoptosis in the mitochondrial pathway, we examined the effect of CCCP treatment on apoptosis under DPV infection.

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PMC8750422

Moreover, the level of intracellular NO in GPR87-overexpressing A549 cells further increased the effect of LPA treatment.

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PMC10547921

After an ADC drug enters the blood circulation and binds to the target antigen receptor on the surface of the tumor cell, the newly formed ADC‒antigen complex will be degraded by lysosomes after internalization, releasing the payload and inducing the tumor cell death (Fig. 1).

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PMC11401358

In addition, SF can also effectively clear excess ROS in the bone marrow mesenchymal stem cells (BMSCs) stimulated by H2O2 in Fig. S5.Fig.

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PMC11541241

Furthermore, the second‐generation TOR inhibitors show more drastic inhibitory effects compared with RAP in P. infestans and U. maydis.

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PMC9429973

To investigate whether SETD2/H3K36me3 loss impinges on the activation and proficiency of HR, we used UV rays to induce DNA damage in SETD2 siRNA-depleted LAMA 84 (SETD2-proficient) cells.

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PMC7724160

These empty cells are considered below the limit of detection but their true value is non-zero.

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PMC11644761

Pterostilbene, found in blueberries, grapes, and grapevines, is a structural analogue of resveratrol and shares many of its properties, including anti-tumor, anti-inflammatory, antioxidant, anti-aging, and anti-obesity effects .

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PMC11767725

Additional relevant studies were identified through manual reviews of reference lists from selected articles.

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PMC11742290

Depending on different TMEs, LGR5 may promote metastasis or activate tumor-suppressive pathways.

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PMC11621565

An efficient neuroprotective treatment does not yet exist due to the unresolved puzzle that is the biomolecular picture of PD.

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PMC11271278

One amplicon is predicted to be a MYC-ERBB2 chimeric ecDNA, similar to what we report in NCIH2170 cells (Fig. S8B).

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PMC11185260

In contrast, combining radiation and scL-vec did not increase the antitumor response compared with radiation treatment alone.

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PMC11532793

sleuth normalizes counts using sample-specific median-ratio size factors (18) followed by a started log-transformation to ensure positivity and normality.

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PMC11665584

Xenium illustrated that PITX1 skin had higher expression of pro-inflammatory genes S100a8 and Il1b in and around the neutrophil-laden areas, with the neutrophils themselves significantly enriched for expression of these markers (Figure 4C and Supplemental Figure 8C).

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PMC5941560

Among the nonsynonymous mutations, 252 variants are nonsense mutations and 10,732 variants are missense mutations. ‘

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PMC11046454

As a proof-of-concept, we exploited the elevated ATP level within the TME and developed an ATP-responsive PTK7-targeting aptamer (ATP-AptPTK7), in which the two ends of AptPTK7 were extended with a split anti-ATP aptamer (Figure 4A).

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PMC9429973

The 2 pts who achieved MLFS and PR died due to PD and fungal pneumonia after 5 and 1.5 months of starting therapy, respectively.

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PMC11627133

N=3 independent experiments) of K D=77±7 nM and K D=56±6 nM, respectively.

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PMC11462673

B Western blotting analysis showed that LDB1 and GAPDH protein pression in Jurkat, 6 T-CEM and J.gamma1 cells after LDB1 knockdown.

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PMC10578720

To determine whether DCA causes hepatotoxic effects, we compared ALT and AST levels between vehicle-treated and DCA-treated rAAV-1.3 HBV mice.

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PMC11531744

The immune-related genes were downloaded from GSEA database (http://www.gsea-msigdb.org/gsea/index.jsp).

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PMC11711663

GLDM LargeDependence HighGrayLevel Emphasis 9.

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PMC9429973

After phlebotomy, there was a significant improvement in his pruritus.

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PMC9503541

Medicinal plants with a long history of ethnopharmacological use have been a valuable source of effective phytochemicals that provide beneficial effects against numerous diseases .

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PMC10079526

Similar results were obtained in U2OS cells (Supplementary Fig. 1C, D).

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PMC10831439

Therefore, part of the effector cells was restimulated with modified target cells every 7 days, while the other part was challenged for 24 hours with PD-L1/2+ cells (figure 3D).

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PMC11674146

CDH2 is a member of the cadherin family that regulates a variety of cellular processes like apoptosis, angiogenesis and chemoresistance and plays a profound role in the EMT (Gao et al., 2018).

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PMC10874773

They found that the potent inhibitory effects of anisatin and (1S)-minwanenone (6) on NCI-H460 and SMMC-7721 cells were comparable to that of 5-FU (Yin, Wang, Wang, & Kong, 2012).

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PMC11711063

Treatments were repeated every 48 h. After 5 days, cells were fixed in 4% formaldehyde and stained with DAPI, HCS‐CellMask‐Red and Phalloidin‐A488.

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PMC11781181

FTH1 was another novel miR-375-3p target in keratinocyte.

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PMC11657695

They form tetramers of α subunits to be active, and these subunits consist of six transmembrane segments and a pore domain.

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PMC9429973

A positive correlation noted between the duration of stay and age of patient (P value 0.05) with a negative correlation between the stay and lymphocyte count (P value -0.024).

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PMC11638255

Neuroblastomas harbor an immunosuppressive tumor microenvironment and therefore combination strategies are now considered more likely to succeed in the restoration of antitumor immunity required for response to anti-GD2 therapy.

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PMC11461833

E,F) Heatmap of SASP related genes and SASP pathway genes that were differentially expressed between empty vector-overexpressing and STXBP5 overexpressing HA-progerin-expressing HEK293 cells. (

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PMC5415764

Accordingly, the coadministration of P-gp inhibitors with anticancer drugs could efficiently overcome efflux-mediated drug resistance3.

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PMC11733919

Hydrodynamic sizes slightly increased when adding the different components of the nanoplatform, which could be indicative of a successful functionalization.

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PMC11757131

This finding is consistent with that of previous research on mice (21).

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PMC11792766

No. N4638) was obtained from Sigma Aldrich.

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PMC11699465

Statistical analysis was performed using Student’s t-test except specific marked and expressed as median with Standard deviation.

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PMC11612794

There are two binding regions for Mis12C (binding regions 1 and 2).

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PMC11188874

Cells were then analyzed on an Attune NxT and quantified using Flow Jo version 10.9.0.

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PMC11092382

Zhu et al. used β-amyloid to induce PC12 neuronal cell damage and evaluated the protective effect of sophocarpine.

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PMC9429973

Image: Summary/Conclusion: In this pilot study, we found that rivaroxaban was safe and well-tolerated as the primary preventive measure for venous thromboembolism in patients with multiple myeloma receiving lenalidomide-based regimen.

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PMC11525293

At 30 h post-infection, cells were washed with PBS, fixed with 4% formaldehyde in PBS for 10 min at room temperature, incubated for 10 min with the reagent containing 4,6-diamidino-2-phenylindole (DAPI), and washed again with PBS.

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PMC11371747

Data were expressed as mean ± SEM and analyzed by a t-test, Pearson correlation or two-way analysis of variance (2-way ANOVA) by GraphPad Prism software, version 5.1.

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PMC11697703

Fezf2 controls multiple aspects of corticofugal neuron identity, including the use of glutamate as neurotransmitter, axonal projection via regulation of guidance molecules such as ephrin-B receptor 1 (EphB1), and is required for normal dendritic morphology.

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