OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11489351	Again, we found that increased pHi using 15%CO2 significantly increased LDHA expression compared to both control MCF10A cells and MCF10A cells where pHi was lowered using S0859 (Fig. S7).Figure 6LDHA and pyruvate dehydrogenase kinase expression increase at high pHi and decrease at low pHi in single cells, leading to pH...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "...
PMC9812014	Alkaloids are a broad group of naturally occurring organic compounds, forming most of the largest group of phytochemicals .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Alkaloids", "are", "a", "broad", ...
PMC11612626	Tumor volume was measured using digital calipers and reported as the product of the two largest perpendicular diameters (mm).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tumor", "volume", ...
PMC9325715	Moreover, the changes in protein structure with formation of more compact arrangement was observed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "the", "changes", "in", "protein", "structu...
PMC11676670	SKOV3 is versatile, as it grows fast, is tolerant to environmental stresses, and its cultivation does not require especial growth conditions or expensive supplements.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11788920	Annealing these two strands resulted in the gRNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Annealing", "these", "two", "strands", "resulted", "in", "the", "gRNA", "." ] } ]
PMC11754784	It should be noted that the our kinetic model is univeral and can be adjusted to describe the kinetic behavior of almost all previously reported microenvironment-confined DNA computing process as implemented in our codes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8009078	It also can be observed that a number of nearby amino acids of catalytic triads were present in close proximity of the proposed ligands.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11653533	This shrub can reach a height of six feet and is categorized into male and female plants.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "shrub", "can", "reach", "a", "heigh...
PMC11699178	After routine incubation for 24 h, when the cell confluence reached around 75%, the medium containing an appropriate amount of packaged lentivirus (MOI = 10, working titer approximately 5 × 10 TU/mL) and 5 μg/mL polybrene (Merck, TR-1003, USA) was added for infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9368503	Dried samples were resuspended in mobile phase A (2% acetonitrile, 0.1% formic acid), spiked with iRT peptides (Biognosys AG, Schlieren, Switzerland), and 2 ug of total peptides were loaded onto a 2 cm × 0.1 mm trap column self-packed with ReproSil Pur C18AQ (120 Å, 10 µm) beads.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11344246	Plates were then imaged at 10× across 25 fields per well on the CellInsight CX7 LED/LZR HCS Platform (Thermo Fisher Scientific) to generate cell counts per well.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10607604	The wound width was evaluated in at least three wells using the Incucyte Cell Migration Scratch Wound Analysis software.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "wound", "width", "was", ...
PMC11721587	WB analysis of Ulk3 SUMOylation in NIH3T3 cells untreated or treated with Shh and without or with TAK981.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "WB", "analysis", "of", "Ulk3", ...
PMC11467964	Construction of the risk score in the training set. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Construction", "of", "the", "risk", "score", "in", "the", "training", "set", ".", "(" ...
PMC11594641	We also observed an increase in cellular CD81 in RAB27A/B KO cells compared to WT cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "observed", "an", "increase", "in", ...
PMC11772585	The migration area was calculated.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "migration", "area", "was", "calculated", "." ] } ]
PMC11155445	Acyl thioureas and thiosemicarbazides of 1-cycloalkane acid chlorides were synthesized and investigated against dihydrofolate reductase (DHFR) by Kholodniak et al. In vitro study revealed that cycloalkane substituted acyl thiourea did not show significant inhibitory activity while thiosemicarbazides (97a–h) were found ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	From dropout hits in PDX in vivo screens, single molecules were validated by fluorochrome-guided competitive in vivo experiments, comparing cells with and without knockout in the same mouse and determining cell distributions by flow cytometry gating on the different recombinant fluorochromes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11530949	The comparative method of 2-ΔΔCt was employed to analyze relative gene expression, with target gene Ct values normalized to β-actin and calibrated against untreated HepG2 cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", ...
PMC10073922	Li et al showed a decreased level of NDRG2 in human lung cancer tissues that was associated with the invasion and tumor size.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Li", ...
PMC11774747	The Center for Cell and Gene Therapy at Baylor College of Medicine in Houston, USA, has been extensively investigating CAR-VSTs targeting antigens such as GD2, CD19, CD30, and HER2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9398137	Protospacer containing pX330 vectors were cotransfected with pcDNA-EmGFP plasmid to distinguish the transfected population by flow cytometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Protospacer", "containing", "pX330", "vectors", "...
PMC11694066	Altogether, these results indicate that PARPi and ATRi elicit a type I IFN response in DSRCT cells that is dependent upon EWS–WT1 expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11423992	The concentration of IL-6, a cytokine associated with inflammation, exhibited statistically significant elevations, while the statistical significance was not observed in the differences in concentration of IL-10, a cytokine associated with immunosuppression (Fig 3C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8348645	The IC50 values for the cytotoxicity tests were derived from nonlinear regression analysis (curve fit) based on the sigmoid dose–response curve (variable) and computed using Graph Pad Prism 6 (Graph pad, San Diego, CA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11747467	Our research well revealed the inhibition effects of ART-combined RC48 against basal bladder cancer both in vivo and in vitro.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "research", "well", ...
PMC6742971	However, adoptive T cell therapy (ACT) is increasingly performed, for example for the treatment of patients with metastatic melanoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However...
PMC5925824	Antibody treatment (indicated by red arrows), either human IgG or LY3300054, was delivered by intra-peritoneal injection in each case at 10 mg/kg.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC4395774	The major advantage of this approach over allogeneic hematopoietic stem cell transplantation is the lack of graft-versus-host disease which is a significant complication in both matched and mismatched transplants.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9444294	As a credentialled in vivo model of the disease, this provides the opportunity to track temporal progression of synovial sarcoma, as opposed to the single advanced timepoint (in tumor evolution) represented in patient surgical samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11763533	It is possible that the larger spectral change observed at 37 and 45 °C for the cells, in relation to the luciferase in vitro, could be caused by additional acidification and stress inside the cells at such high temperatures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11627133	Staining with each AP3‐SiRA construct consistently resulted in colocalization of the GFP and SiR fluorescence signals for all fusion designs, whereas minimal fluorescence was observed for the negative control samples SiRA and AP3 (Figure 4C, D, Figure S6J–M, Figure S7A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Twenty-two patients from 7 countries consented to this research: 16 EBV PTLD and 6 EBV non-PTLD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Twenty-two", "patients", "from", "7", "countries"...
PMC11804588	However, these assays typically require large numbers of cells and deep DNA sequencing, limiting their application to bulk samples and precluding the resolution of combinatorial TF-binding events on the same DNA molecules. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11674146	Further, CLP36 silencing repressed the expressions of Cadherin 2 (CDH2) and Vimentin (VIM) yet promoted those of Bax and Caspase 3 in lymphoma cells, concurrent with the reduction on the phosphorylation of PI3K, AKT and CREB, all of which were confirmed to be positively correlated with CLP36.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11144382	This identified 191 transcripts and 815 proteins misregulated in Nfix MEFs with ≥2-fold-change (P <0 .05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "identified", "191", "tran...
PMC11530949	The data were presented as mean standard deviation (SD).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "data", "were", "presented", "as", "mean", "standard", "deviation", "(", "SD", ...
PMC5833712	That the proteasome inhibitor MG132 prevented loss of the ERα protein, following activation of ERβ with KB9520, suggests that ERβ is responsible for targeting ERα for proteasome pathway degradation (Fig. 3a, b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767725	IL-6 disrupts insulin sensitivity via the janus kinase/signal transducers and activators of transcription (JAK/STAT) pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IL-6", "disrupts", "insulin", "sensitivity", "via...
PMC11786156	In clinical settings, CD54-negative non-Hodgkin lymphoma cases showed a poorer prognosis than CD54-positive cases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "clinical", "settings", ",", "CD54-negative", "non-Hodgkin",...
PMC6379402	Finally, we extend this analysis to uncover pan-cancer genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "we", "extend", "this", "analysis", "to", "uncover", "pan-cancer", "genes", ...
PMC11676670	Mutations in this pathway are frequently associated with aberrant cell signaling and have been implicated in tumor growth and survival, suggesting that OVAR79 may serve as a useful model for studying PI3K/AKT pathway dysregulation in ovarian cancer .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11768281	Within this phase, specific subsets of DCs, such as CD8α+ DCs, have been identified as particularly efficient in antigen presentation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Within"...
PMC11697703	Overall, our results using multiple approaches (i.e., in vivo GoF, in vitro GoF and LoF, multiple cell types) indicate that miR-193b∼365 cluster contributes to regulating dendritic development in specific cortical neuron types via regulation of MAPK8 signaling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11731614	The tip of an Eppendorf 200ul pipette tip (Fisher 02707409) was used to form a vertical scratch down the center.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "tip",...
PMC11661024	The β-actin gene was selected as the control due to the constant expression in all cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "β-actin", "gene", "was", "selected", "as", ...
PMC11754094	The boxes represent the interquartile range and the center lines represent the median.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "boxes", "represent", "the", "interquartile", "range", "and", "the", ...
PMC11484188	The luciferase assay indicated that miR-1343-3p bound ATG7 3'UTR and decreased its luciferase activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "luciferase", "assay", "indicated", "that", "miR...
PMC3888431	CHO-K1 cells were cultured in four independent fermenters, one exposed to temperature stress and one exposed to pH-shift to include a broad range of diverse transcripts.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11711871	Under standard and high-salt diet conditions, both groups significantly gained weight over time.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Under", "standard", "and", "high-salt", "diet", "conditions", ",", ...
PMC9341513	A quantitative analysis of within-domain loops found in HiChIP data shows that the simulations correctly predict an enrichment of these interactions (Supplemental Fig. S2G; see Supplemental Methods Section 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11247842	In summary, each partner used GCTA-MLMA to conduct an association study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "summary", ",", "each", "partner", "used", "GCTA-MLMA", "to", "conduct", ...
PMC9429973	On the other hand, rather than gedatolisib, omipalisib could significantly inhibit expression of glycolysis-related genes (GLUT1, HK2, PKM2, and LDHA) as well as mitochondrial biogenesis-related genes (PPARGC1B, TFAM, and NDUFS6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Seventy percent of patients received proteasome inhibitor and immunomodulatory agents at induction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Seventy", "percent", "of", "patients", "received", "proteasome", "inhibitor", "and", ...
PMC10759659	Scale bar = 100 μm or 50 μm. (*	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", "=", "100", "μm", "or", "50", "μm", ".", "(", "*" ] } ]
PMC9429973	Results: The survey showed that only 50% of centers have specific guidelines for gamete cryopreservation and while in all of them fertility is discussed with the hematologist, only in 50% of centers the patient is referred to a fertility specialist.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10170482	We suggest that the soft microenvironment induces liver tumor cellular dormancy accompanied by reduced mitochondrial activity and elevated glycolysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "suggest", "that", "the", ...
PMC9429973	We analyzed the signaling responses downstream of activated CXCR4, for which GOF phenotypes had been reported in R334X patient cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "analyzed", ...
PMC11566417	Image processing and analysis was performed using ImageJ .Table 2Antibodies used for immunofluorescent imagingTargetHostCloneDilutionManufacturerIdentifierVimentinMouseRV2021:100AbcamCat# ab8978Alpha smooth muscle actinMouse1A4 (conjugated to AF594)1:100AbcamCat# ab202368Cytokeratin 14MouseLL0021:100AbcamCat# ab7800Est...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10940855	Because silencing EFNB2 in multiple myeloma cells suppressed multiple myeloma growth in vitro and in vivo, we next examined whether enforcement of EFNB2 expression in multiple myeloma cells could increase multiple myeloma pathogenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11700523	Animal experiments The animal protocols were approved by the institutional animal care and use committee of Oita University (Approval number: 181503).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11765243	After washing, the cells were cultured at 10 cells/mL in 24- or 48-well culture plates (Costar 3524, 1 mL/well, or Costar 3548, 0.5 mL/well) that were pre-coated with anti-CD3 antibodies (YCD3-1, 5 µg/mL ) and specific antibodies and cytokines were added.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6835428	Following the IV injection of lipid–PEG–Cy5.5–siKSP in a subcutaneous xenograft model of OC, the authors observed an accumulation of the particles in the kidney and liver, with a detectable amount also found in the tumor mass.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11391695	Consequently, PEI was employed in conjunction with NPs to enhance the efficacy of the action.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consequently", ",", "PEI", "was", "employed", "in", ...
PMC8978939	Minimizations and MD simulations were carried out with the pmemd.cuda module of AMBER16 (45).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Minimizations", "and", "MD", "simulations", "were", "c...
PMC11052306	The biological properties of both randomly functionalized dendrimers shown in Figure 6 were tested in comparison with the dendrimers fully complexed with either copper (2-G3-Cu48) or gold (2-G3-[Au48][AuCl4]48), as shown in Figure 7.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11727000	The association with the protein CD2BP2 is intriguing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "association", "with", "the", "protein", "CD2BP2", "is", "intriguing", "." ] } ]
PMC9429973	No differences in weight variations from admission to discharge were observed comparing arm A and arm B (mean 4.15kg vs 3.66kg, p=0.3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11627398	The volcano plot displayed the differential expressed lncRNAs between control and septic shock groups in the GSE57065 cohort. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "volcano", "plot", "display...
PMC8193046	However, even for these well-studied ABC transporters, only 133 broad-spectrum ABCB1, ABCC1, and ABCG2 inhibitors were described to date , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , amongst which only 56 exerted their effects below 10 µM , , , , , , , , , , , , , , , , , , , , , , , ,...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: Observational, ambispective, descriptive study with 110 TNE-NDMM patients who started antineoplastic treatment within daily clinical practice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "Observationa...
PMC11463018	In cellular assay, compounds 16a, 16b, 16c, 16j and 19 showed potent antiproliferative activity against human MM cell line RPMI-8226 and breast cancer cell line MDA-MB-231.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11683240	C57BL/6 pairs (Jackson Laboratory) were bred in-house, and seven-day-old pups were treated in accordance with and approved by the University of Maryland, Baltimore (UMB), Institutional Animal Care and Use Committee (AUP 1122017).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11640247	However, the affinities to PAK1 and N-WASP were weaker compared to RAC3-Q61L (Figure 3A–D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "affinities...
PMC8540692	The principle of the method is based on dihydroethidium (DHE), which is cell permeable and upon reaction with superoxide anions undergoes oxidation to form the DNA-binding fluorophore.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11597167	cDNA was stored at −20 °C for long-term storage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "cDNA", "was", "stored", "at", "−20", "°", "C", "for", "long-term", "storage", "." ] ...
PMC3164356	This result suggests that CHO-K1 lacks HS3ST activity, which is consistent with the lack of detectable HS3ST expression in our study.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", ...
PMC11449273	This indicates a role for plakoglobin in the modulation of PUMA and BAX expression in p53-WT as well as mutant (p53-175 and -273) expressing cells even in the absence of cellular stresses such as DNA damage .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11453018	LMNB1 (GFP-LMNB1) and control GFP were overexpressed in SKES1 cells using retrovirus vectors pQCXIP-GFP and pQCXIP-GFP-myc-HsLMNB1, generously provided by Dr. Stephen A. Adam from Northwestern University .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742231	one-hot)Degree0–10 (one-hot)Implicit valence0–6 (one-hot)Formal chargeFormal charge number (integer)Radical electronsNumber of radical electrons (integer)HybridizationSP, SP2, SP3, SP3D, SP3D2 (one-hot or null)AromaticWhether the atom is in an aromatic system (binary)Hydrogens0–4 (one-hot)RingWhether the atom is in a r...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: In this retrospective investigation, we aim to investigate the genotype-phenotype correlation based on the clinical severity of the disease and the gene-wise predicted pathogenicity comparison.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9817179	Our quantitative image analysis suggests that depending on the LLPS-driving protein, fixing cells can either enhance or diminish the apparent LLPS behaviors in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC8567602	P values at top are the comparison of each cell line to HEK293T for CBAF fractional abundance, by two-tailed heteroscedastic t test.)	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11026382	c Structural location of epistatic clusters for DHFR to TYMS R166Q.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "c", "Structural", "location", "of", "epistatic", "clusters", "for", "DHFR", "to", "TY...
PMC8735881	Figure 3.Anti-HIV activities of GPI-scFvs in transduced cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "3.Anti-HIV", "activities", "of", "GPI-scFvs", "in", "transduced", "cells", "." ] } ]
PMC11794588	Anwar et al. found that lupeol suppresses liver cancer cell proliferation by inhibiting the PI3K/AKT signaling pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Anwar", "et", "al.", "found", "that", "lupe...
PMC9164404	Besides, it was found that Abplatin affected more genes expression than cisplatin, like that ABAT and CLDN6 were significantly up-regulated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Besides", ",...
PMC11011837	Moreover, the cell lines are from different genders and ages (Jurkat: 14-year-old male, CCRF-CEM: 3-year-old girl, Molt-4: 19-year-old man, and Molt-16: 5-year-old girl); however, it appears that the sex and age of the patients from whom these lines were derived do not influence or explain the clustering shown in the P...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O"...
PMC11401358	The scanning speed was 100 nm/min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "scanning", "speed", "was", "100", "nm/min", "." ] } ]
PMC8759873	The UV luminosity is A260 and A280 respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "UV", "luminosity", "is", "A260", "and", "A280", "respectively", "." ] } ]
PMC11548041	The complexation of the EpCAM intracellular domain with members of the Wnt signaling pathway drives expression of oncogenes such as c-myc .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "complexation", ...
PMC11683240	Cells were left untreated as control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "left", "untreated", "as", "control", "." ] } ]
PMC11653533	In addition, it could be a well-known fancy tree, more often than not developed in numerous warm temperate, subtropical, and tropical districts of the world, hence naturalized in Los Angeles, Orange, Riverside, San Diego, Wander provinces, and Southern California (Riefner, 2016).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10142392	It was discovered that the PCL:PGMA ratios exerted a significant influence on the properties of the copolymers, particularly their micellization properties.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11247842	The lead SNP for the fourth strongest association signal was BTA21: 62,941,833 (rs136844062) and was an intergenic variant near 5S_rRNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11574271	H The migratory capacity of 5637-NC, 5637-shRON, J82-NC, and J82-oeRON cells was assessed using a wound healing assay.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11546117	Mounting medium with DAPI to counterstain the nuclei was added on slide and on top of the membrane.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mounting", "medium", "with", "DAPI", "...
PMC11621493	Changes in specific lipid classes are shown in Figure 8B–D. Under basal conditions, we did not find major differences between genotypes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11047729	Telomerase, a key enzyme responsible for maintaining telomere length and promoting cellular immortality, is often up-regulated in leukemia cells, contributing to their uncontrolled proliferation and survival.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11489351

Again, we found that increased pHi using 15%CO2 significantly increased LDHA expression compared to both control MCF10A cells and MCF10A cells where pHi was lowered using S0859 (Fig. S7).Figure 6LDHA and pyruvate dehydrogenase kinase expression increase at high pHi and decrease at low pHi in single cells, leading to pH...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "...

PMC9812014

Alkaloids are a broad group of naturally occurring organic compounds, forming most of the largest group of phytochemicals .

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PMC11612626

Tumor volume was measured using digital calipers and reported as the product of the two largest perpendicular diameters (mm).

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PMC9325715

Moreover, the changes in protein structure with formation of more compact arrangement was observed.

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PMC11676670

SKOV3 is versatile, as it grows fast, is tolerant to environmental stresses, and its cultivation does not require especial growth conditions or expensive supplements.

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PMC11788920

Annealing these two strands resulted in the gRNA.

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PMC11754784

It should be noted that the our kinetic model is univeral and can be adjusted to describe the kinetic behavior of almost all previously reported microenvironment-confined DNA computing process as implemented in our codes.

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PMC8009078

It also can be observed that a number of nearby amino acids of catalytic triads were present in close proximity of the proposed ligands.

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PMC11653533

This shrub can reach a height of six feet and is categorized into male and female plants.

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PMC11699178

After routine incubation for 24 h, when the cell confluence reached around 75%, the medium containing an appropriate amount of packaged lentivirus (MOI = 10, working titer approximately 5 × 10 TU/mL) and 5 μg/mL polybrene (Merck, TR-1003, USA) was added for infection.

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PMC9368503

Dried samples were resuspended in mobile phase A (2% acetonitrile, 0.1% formic acid), spiked with iRT peptides (Biognosys AG, Schlieren, Switzerland), and 2 ug of total peptides were loaded onto a 2 cm × 0.1 mm trap column self-packed with ReproSil Pur C18AQ (120 Å, 10 µm) beads.

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PMC11344246

Plates were then imaged at 10× across 25 fields per well on the CellInsight CX7 LED/LZR HCS Platform (Thermo Fisher Scientific) to generate cell counts per well.

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PMC10607604

The wound width was evaluated in at least three wells using the Incucyte Cell Migration Scratch Wound Analysis software.

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PMC11721587

WB analysis of Ulk3 SUMOylation in NIH3T3 cells untreated or treated with Shh and without or with TAK981.

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PMC11467964

Construction of the risk score in the training set. (

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PMC11594641

We also observed an increase in cellular CD81 in RAB27A/B KO cells compared to WT cells.

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PMC11772585

The migration area was calculated.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "migration", "area", "was", "calculated", "." ] } ]

PMC11155445

Acyl thioureas and thiosemicarbazides of 1-cycloalkane acid chlorides were synthesized and investigated against dihydrofolate reductase (DHFR) by Kholodniak et al. In vitro study revealed that cycloalkane substituted acyl thiourea did not show significant inhibitory activity while thiosemicarbazides (97a–h) were found ...

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PMC9429973

From dropout hits in PDX in vivo screens, single molecules were validated by fluorochrome-guided competitive in vivo experiments, comparing cells with and without knockout in the same mouse and determining cell distributions by flow cytometry gating on the different recombinant fluorochromes.

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PMC11530949

The comparative method of 2-ΔΔCt was employed to analyze relative gene expression, with target gene Ct values normalized to β-actin and calibrated against untreated HepG2 cancer cells.

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PMC10073922

Li et al showed a decreased level of NDRG2 in human lung cancer tissues that was associated with the invasion and tumor size.

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PMC11774747

The Center for Cell and Gene Therapy at Baylor College of Medicine in Houston, USA, has been extensively investigating CAR-VSTs targeting antigens such as GD2, CD19, CD30, and HER2.

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PMC9398137

Protospacer containing pX330 vectors were cotransfected with pcDNA-EmGFP plasmid to distinguish the transfected population by flow cytometry.

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PMC11694066

Altogether, these results indicate that PARPi and ATRi elicit a type I IFN response in DSRCT cells that is dependent upon EWS–WT1 expression.

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PMC11423992

The concentration of IL-6, a cytokine associated with inflammation, exhibited statistically significant elevations, while the statistical significance was not observed in the differences in concentration of IL-10, a cytokine associated with immunosuppression (Fig 3C).

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PMC8348645

The IC50 values for the cytotoxicity tests were derived from nonlinear regression analysis (curve fit) based on the sigmoid dose–response curve (variable) and computed using Graph Pad Prism 6 (Graph pad, San Diego, CA, USA).

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PMC11747467

Our research well revealed the inhibition effects of ART-combined RC48 against basal bladder cancer both in vivo and in vitro.

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PMC6742971

However, adoptive T cell therapy (ACT) is increasingly performed, for example for the treatment of patients with metastatic melanoma.

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PMC5925824

Antibody treatment (indicated by red arrows), either human IgG or LY3300054, was delivered by intra-peritoneal injection in each case at 10 mg/kg.

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PMC4395774

The major advantage of this approach over allogeneic hematopoietic stem cell transplantation is the lack of graft-versus-host disease which is a significant complication in both matched and mismatched transplants.

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PMC9444294

As a credentialled in vivo model of the disease, this provides the opportunity to track temporal progression of synovial sarcoma, as opposed to the single advanced timepoint (in tumor evolution) represented in patient surgical samples.

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PMC11763533

It is possible that the larger spectral change observed at 37 and 45 °C for the cells, in relation to the luciferase in vitro, could be caused by additional acidification and stress inside the cells at such high temperatures.

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PMC11627133

Staining with each AP3‐SiRA construct consistently resulted in colocalization of the GFP and SiR fluorescence signals for all fusion designs, whereas minimal fluorescence was observed for the negative control samples SiRA and AP3 (Figure 4C, D, Figure S6J–M, Figure S7A).

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PMC9429973

Twenty-two patients from 7 countries consented to this research: 16 EBV PTLD and 6 EBV non-PTLD.

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PMC11804588

However, these assays typically require large numbers of cells and deep DNA sequencing, limiting their application to bulk samples and precluding the resolution of combinatorial TF-binding events on the same DNA molecules. (

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PMC11674146

Further, CLP36 silencing repressed the expressions of Cadherin 2 (CDH2) and Vimentin (VIM) yet promoted those of Bax and Caspase 3 in lymphoma cells, concurrent with the reduction on the phosphorylation of PI3K, AKT and CREB, all of which were confirmed to be positively correlated with CLP36.

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PMC11144382

This identified 191 transcripts and 815 proteins misregulated in Nfix MEFs with ≥2-fold-change (P <0 .05).

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PMC11530949

The data were presented as mean standard deviation (SD).

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PMC5833712

That the proteasome inhibitor MG132 prevented loss of the ERα protein, following activation of ERβ with KB9520, suggests that ERβ is responsible for targeting ERα for proteasome pathway degradation (Fig. 3a, b).

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PMC11767725

IL-6 disrupts insulin sensitivity via the janus kinase/signal transducers and activators of transcription (JAK/STAT) pathways.

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PMC11786156

In clinical settings, CD54-negative non-Hodgkin lymphoma cases showed a poorer prognosis than CD54-positive cases.

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PMC6379402

Finally, we extend this analysis to uncover pan-cancer genes.

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PMC11676670

Mutations in this pathway are frequently associated with aberrant cell signaling and have been implicated in tumor growth and survival, suggesting that OVAR79 may serve as a useful model for studying PI3K/AKT pathway dysregulation in ovarian cancer .

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PMC11768281

Within this phase, specific subsets of DCs, such as CD8α+ DCs, have been identified as particularly efficient in antigen presentation.

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PMC11697703

Overall, our results using multiple approaches (i.e., in vivo GoF, in vitro GoF and LoF, multiple cell types) indicate that miR-193b∼365 cluster contributes to regulating dendritic development in specific cortical neuron types via regulation of MAPK8 signaling.

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PMC11731614

The tip of an Eppendorf 200ul pipette tip (Fisher 02707409) was used to form a vertical scratch down the center.

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PMC11661024

The β-actin gene was selected as the control due to the constant expression in all cells.

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PMC11754094

The boxes represent the interquartile range and the center lines represent the median.

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PMC11484188

The luciferase assay indicated that miR-1343-3p bound ATG7 3'UTR and decreased its luciferase activity.

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PMC3888431

CHO-K1 cells were cultured in four independent fermenters, one exposed to temperature stress and one exposed to pH-shift to include a broad range of diverse transcripts.

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PMC11711871

Under standard and high-salt diet conditions, both groups significantly gained weight over time.

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PMC9341513

A quantitative analysis of within-domain loops found in HiChIP data shows that the simulations correctly predict an enrichment of these interactions (Supplemental Fig. S2G; see Supplemental Methods Section 4).

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PMC11247842

In summary, each partner used GCTA-MLMA to conduct an association study.

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PMC9429973

On the other hand, rather than gedatolisib, omipalisib could significantly inhibit expression of glycolysis-related genes (GLUT1, HK2, PKM2, and LDHA) as well as mitochondrial biogenesis-related genes (PPARGC1B, TFAM, and NDUFS6).

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PMC9429973

Seventy percent of patients received proteasome inhibitor and immunomodulatory agents at induction.

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PMC10759659

Scale bar = 100 μm or 50 μm. (*

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PMC9429973

Results: The survey showed that only 50% of centers have specific guidelines for gamete cryopreservation and while in all of them fertility is discussed with the hematologist, only in 50% of centers the patient is referred to a fertility specialist.

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PMC10170482

We suggest that the soft microenvironment induces liver tumor cellular dormancy accompanied by reduced mitochondrial activity and elevated glycolysis.

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PMC9429973

We analyzed the signaling responses downstream of activated CXCR4, for which GOF phenotypes had been reported in R334X patient cells.

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PMC11566417

Image processing and analysis was performed using ImageJ .Table 2Antibodies used for immunofluorescent imagingTargetHostCloneDilutionManufacturerIdentifierVimentinMouseRV2021:100AbcamCat# ab8978Alpha smooth muscle actinMouse1A4 (conjugated to AF594)1:100AbcamCat# ab202368Cytokeratin 14MouseLL0021:100AbcamCat# ab7800Est...

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PMC10940855

Because silencing EFNB2 in multiple myeloma cells suppressed multiple myeloma growth in vitro and in vivo, we next examined whether enforcement of EFNB2 expression in multiple myeloma cells could increase multiple myeloma pathogenesis.

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PMC11700523

Animal experiments The animal protocols were approved by the institutional animal care and use committee of Oita University (Approval number: 181503).

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PMC11765243

After washing, the cells were cultured at 10 cells/mL in 24- or 48-well culture plates (Costar 3524, 1 mL/well, or Costar 3548, 0.5 mL/well) that were pre-coated with anti-CD3 antibodies (YCD3-1, 5 µg/mL ) and specific antibodies and cytokines were added.

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PMC6835428

Following the IV injection of lipid–PEG–Cy5.5–siKSP in a subcutaneous xenograft model of OC, the authors observed an accumulation of the particles in the kidney and liver, with a detectable amount also found in the tumor mass.

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PMC11391695

Consequently, PEI was employed in conjunction with NPs to enhance the efficacy of the action.

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PMC8978939

Minimizations and MD simulations were carried out with the pmemd.cuda module of AMBER16 (45).

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PMC11052306

The biological properties of both randomly functionalized dendrimers shown in Figure 6 were tested in comparison with the dendrimers fully complexed with either copper (2-G3-Cu48) or gold (2-G3-[Au48][AuCl4]48), as shown in Figure 7.

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PMC11727000

The association with the protein CD2BP2 is intriguing.

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PMC9429973

No differences in weight variations from admission to discharge were observed comparing arm A and arm B (mean 4.15kg vs 3.66kg, p=0.3).

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PMC11627398

The volcano plot displayed the differential expressed lncRNAs between control and septic shock groups in the GSE57065 cohort. (

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PMC8193046

However, even for these well-studied ABC transporters, only 133 broad-spectrum ABCB1, ABCC1, and ABCG2 inhibitors were described to date , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , amongst which only 56 exerted their effects below 10 µM , , , , , , , , , , , , , , , , , , , , , , , ,...

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PMC9429973

Methods: Observational, ambispective, descriptive study with 110 TNE-NDMM patients who started antineoplastic treatment within daily clinical practice.

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PMC11463018

In cellular assay, compounds 16a, 16b, 16c, 16j and 19 showed potent antiproliferative activity against human MM cell line RPMI-8226 and breast cancer cell line MDA-MB-231.

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PMC11683240

C57BL/6 pairs (Jackson Laboratory) were bred in-house, and seven-day-old pups were treated in accordance with and approved by the University of Maryland, Baltimore (UMB), Institutional Animal Care and Use Committee (AUP 1122017).

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PMC11640247

However, the affinities to PAK1 and N-WASP were weaker compared to RAC3-Q61L (Figure 3A–D).

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PMC8540692

The principle of the method is based on dihydroethidium (DHE), which is cell permeable and upon reaction with superoxide anions undergoes oxidation to form the DNA-binding fluorophore.

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PMC11597167

cDNA was stored at −20 °C for long-term storage.

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PMC3164356

This result suggests that CHO-K1 lacks HS3ST activity, which is consistent with the lack of detectable HS3ST expression in our study.

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PMC11449273

This indicates a role for plakoglobin in the modulation of PUMA and BAX expression in p53-WT as well as mutant (p53-175 and -273) expressing cells even in the absence of cellular stresses such as DNA damage .

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PMC11453018

LMNB1 (GFP-LMNB1) and control GFP were overexpressed in SKES1 cells using retrovirus vectors pQCXIP-GFP and pQCXIP-GFP-myc-HsLMNB1, generously provided by Dr. Stephen A. Adam from Northwestern University .

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PMC11742231

one-hot)Degree0–10 (one-hot)Implicit valence0–6 (one-hot)Formal chargeFormal charge number (integer)Radical electronsNumber of radical electrons (integer)HybridizationSP, SP2, SP3, SP3D, SP3D2 (one-hot or null)AromaticWhether the atom is in an aromatic system (binary)Hydrogens0–4 (one-hot)RingWhether the atom is in a r...

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PMC9429973

Aims: In this retrospective investigation, we aim to investigate the genotype-phenotype correlation based on the clinical severity of the disease and the gene-wise predicted pathogenicity comparison.

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PMC9817179

Our quantitative image analysis suggests that depending on the LLPS-driving protein, fixing cells can either enhance or diminish the apparent LLPS behaviors in vivo.

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PMC8567602

P values at top are the comparison of each cell line to HEK293T for CBAF fractional abundance, by two-tailed heteroscedastic t test.)

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PMC11026382

c Structural location of epistatic clusters for DHFR to TYMS R166Q.

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PMC8735881

Figure 3.Anti-HIV activities of GPI-scFvs in transduced cells.

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PMC11794588

Anwar et al. found that lupeol suppresses liver cancer cell proliferation by inhibiting the PI3K/AKT signaling pathway.

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PMC9164404

Besides, it was found that Abplatin affected more genes expression than cisplatin, like that ABAT and CLDN6 were significantly up-regulated.

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PMC11011837

Moreover, the cell lines are from different genders and ages (Jurkat: 14-year-old male, CCRF-CEM: 3-year-old girl, Molt-4: 19-year-old man, and Molt-16: 5-year-old girl); however, it appears that the sex and age of the patients from whom these lines were derived do not influence or explain the clustering shown in the P...

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PMC11401358

The scanning speed was 100 nm/min.

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PMC8759873

The UV luminosity is A260 and A280 respectively.

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PMC11548041

The complexation of the EpCAM intracellular domain with members of the Wnt signaling pathway drives expression of oncogenes such as c-myc .

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PMC11683240

Cells were left untreated as control.

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PMC11653533

In addition, it could be a well-known fancy tree, more often than not developed in numerous warm temperate, subtropical, and tropical districts of the world, hence naturalized in Los Angeles, Orange, Riverside, San Diego, Wander provinces, and Southern California (Riefner, 2016).

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PMC10142392

It was discovered that the PCL:PGMA ratios exerted a significant influence on the properties of the copolymers, particularly their micellization properties.

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PMC11247842

The lead SNP for the fourth strongest association signal was BTA21: 62,941,833 (rs136844062) and was an intergenic variant near 5S_rRNA.

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PMC11574271

H The migratory capacity of 5637-NC, 5637-shRON, J82-NC, and J82-oeRON cells was assessed using a wound healing assay.

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PMC11546117

Mounting medium with DAPI to counterstain the nuclei was added on slide and on top of the membrane.

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PMC11621493

Changes in specific lipid classes are shown in Figure 8B–D. Under basal conditions, we did not find major differences between genotypes.

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PMC11047729

Telomerase, a key enzyme responsible for maintaining telomere length and promoting cellular immortality, is often up-regulated in leukemia cells, contributing to their uncontrolled proliferation and survival.

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