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OTAR3088
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BioData-CellLine_annotated

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PMC10165258
After each laminating step, the photoresist film was exposed to UV (LightningCure, Hamamatsu) through a photomask of the junction, channels, trapping chamber boundaries or anchors.
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PMC11543885
Expand the hygromycin-resistant cell colonies and verify the expression of flag-NLRP3 or flag-NLRP3-APEX2 fusion construct by western blotting.
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PMC11806106
Sensor L265 short: fragment 1 fw and vector+mTurq rev same as M264, fragment 2 rev and vector-mTurq fwd same as M264 short, fragment 1 rev, YFP fwd, YFP rev and fragment 2 fwd same as L265.
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PMC9872547
Considering the importance of cervical cancer, this study examined the effect of nano-curcumin on the expression of E6, E7, Rb, and P53 in the RNA and protein levels of HeLa cancer cell lines.
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PMC11594641
Our reasoning is that the least invasive cell line was more susceptible to the weakening of its aggressive capabilities.
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PMC10092581
About 10 H157 cells were seeded in 24‐well plates and, after 24 h incubation, were treated with the tested compounds and incubated for additional 24 h. Cells were then washed with cold PBS, harvested, and directly fixed with 1.5 % glutaraldehyde buffer with 0.2 M sodium cacodylate, pH 7.4.
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PMC11402217
OS mouse survival rates per group. (
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PMC11521786
Effector functions of MAbs have been linked to the recognition of different structural regions.
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PMC9318744
An aliquot of the reconstituted virus was used for a low MOI infection of ~90% confluent Vero E6 cells.
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PMC11683130
As the main target protease of SerpinA12, KLK7 controls the process of the activation of pro-inflammatory IL-1β and prochemerin, all of which are involved in the pathogenesis of psoriasis (133, 134, 166).
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PMC9844987
Box-and-whisker plots of the IQRs (widths containing the 25th to 75th percentiles of contained CAGE signal) split based on levels of lowest Pearson correlation between any pair of decomposed promoters originating from the same promoter (central band: median; boundaries: first and third quartiles; whiskers:+/-1.5 IQR).
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PMC9429973
IgHV1-69 gene is more associated with ethnicity, but not a gender.
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PMC9532503
It was observed that Capto SP ImPres® resin with 50 mg anti-CD20 antibody per mL of resin as binding capacity at 6 min residence time with elution buffer of 50 mM Tris and 100 mM NaCl, at pH 9.0 was optimal.
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PMC11754094
We found that ExCas-Analyzer exhibited higher analysis speed and lower usage of memory with high accuracy than BWA-mem and CRISPResso2 (Supplementary Fig. 2).
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PMC11064533
Next, 1 mL of PBS with 1% Triton X-100 was added per well, the plate was incubated for 5 min at room temperature, and finally, the contents of the well were scraped by pipetting in each well and mixed thoroughly.
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PMC9429973
The cells were treated with colchicine and hypotonic KCl solution.
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PMC11394227
Cell engineering methods to inhibit or delay apoptosis have been developed in CHO cells, focusing on manipulating pro-apoptotic and anti-apoptotic proteins .
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PMC11453295
We hypothesize that E-cadherin loss accelerates estrogen-driven tumorigenesis by reprogramming ER DNA binding through the dysregulation of pathways and transcription factors linked to E-cadherin.
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PMC11568601
Studies have demonstrated that phosphorylation is required for the activation of IRE1 protein , indicating that TGT promoted the activity of IRE1 and subsequently activated downstream ER stress-associated signaling pathways.
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PMC11682224
The CCK-8 data showed that the OD value in the CHD1L-OE group was much higher than in the NC group, whereas in the CHD1L-KD group it was significantly lower.
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PMC11190062
Analyses were run using R version 4.3.2 (2023–10-31).
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PMC9429973
The median age was 20 years (range: 1-74) with 328 (57%) males and 245 (43%) females.
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PMC9429973
One patient showed progressive disease.
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PMC11777207
Shown are live cells. (
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PMC6222635
The plant Dendrobium officinale has been used for thousands of years in China as a folk medicine.
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PMC11119602
The dramatic nature of this change that accompanied the cellular toxicity of cisplatin to parental cells was not seen in cisplatin-treated chemoresistant HepG2/cr cells, where toxicity effects were greatly reduced and where TG2-S remained almost entirely membrane-associated (Figure 6C).
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PMC11753949
These properties suggest that synaptopodin could mediate the close apposition of ER elements observed in the spine apparatus via an intervening actin matrix.
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PMC11471176
Table 1Time Point in MinutesTest Compound217324762Carnosine (mM)442622 ± 28713 ± 55762 ± 50897 ± 57896 ± 143Slope = 4.9% Inhibition = 85 %2211549 ± 1411891 ± 2922386 ± 1352319 ± 2803036 ± 119Slope = 22.7% Inhibition = 29 %1101856 ± 2432469 ± 2112868 ± 2553291 ± 4253402 ± 540Slope = 26.1% Inhibition = 18 %551948 ± 51625...
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PMC11634027
Statistical significance of differences compared to ds is in green.
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PMC7961460
All other cells were grown in RPMI1640 with stable L-glutamine culture medium (ECM2001L; Euroclone) supplemented with 10% fetal bovine serum (FBS) EU Approved (ECS0180D; Euroclone) and 100 U/mL penicillin + 100 µg/mL streptomycin (ECB3001D; Euroclone) in an atmosphere of humidified 95% air, 5% CO2 at 37 °C in tissue cu...
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PMC11488203
Nevertheless, the effects of taxol on the elevated transcripts of miRs with tumor-suppressive functionalities paralleled by the enhanced tumor tropism of increased SDF-1 expression potentiated these drug results.
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PMC11618052
Compounds 8a–t were evaluated for their antiproliferative efficacy against a panel of four cancer cell lines.
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PMC9844987
For all box-and-whisker plots, central band: median; boundaries: first and third quartiles; whiskers:+/-1.5 IQR.
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PMC11754291
Our study demonstrates how different blue light parameters (5 mW/cm to 50 mW/cm) affect both cellular metabolic activity and melanogenic responses in primary cultured human keratinocytes and melanocytes.
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PMC8481254
For the soft agar colony-formation assay, Bel-7402 and Bel-7404 cells (initially 6 × 10 cells/well) were seeded into a 6-well plate with 0.3% agarose in DMEM containing 10% FBS.
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PMC8753818
Caspase-3 and caspase-7 are responsible for the majority of cleavages that occur during apoptosis .
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PMC11700247
Survival curve after treatment administration. (
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PMC5839394
Wounds were created by scraping the monolayer of cells with a sterile pipette tip, washed with PBS to remove the floating cells and incubated with fresh medium in the presence or absence of AgNPs-EPS.
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PMC9318744
This is consistent with recent reports that camostat mesylate significantly reduces SARS-CoV-2-driven entry and infection in primary human lung cells .
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PMC10743717
Although the change of A340 with time was observed at 5 min for the oxidation of 17β-estradiol catalyzed by 17β-HSD10/SCHAD (see Figure 3a of Ref. ),
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PMC11541409
This reference is of outstanding importance because it reports that ripretinib has the similar effcicay with sunitinib as a second line therapy drug for GIST patients after imatinib failure.
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PMC11680982
Neratinib can, through HER2’s 3’-UTR region binding hsa-miR-23a-5p and reducing HER2 mRNA stability, effectively downregulate Cyclin D1 and CDK4 by targeting the HER2 pathway, resulting in G1 arrest, and cancer cell proliferation, with enhanced efficacy of CDK4/6 inhibitors combined with endocrine therapy in HR/HER2-lo...
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PMC9429973
The MYC expression was significantly higher in tFL than in the corresponding FL (Figure 1C).
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PMC9429973
6.
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PMC6617630
We examined the sensitivity of BET bromodomain small molecule inhibitors (BETi) such as I-BET-762 (I-BET), JQ1, or OTX015 (OTX) in DHL, THL, and SH cell lines harboring MYC rearrangement with BCL2 and/or BCL6.
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PMC11528603
Thus, to understand the effects of SA-EA on HL60 cell growth, we investigated the relative transcription level of CDKN1A and PCNA genes which are important in cell cycle arrest and DNA replication respectively.
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PMC11706297
According to the results, BTT-1–10 occupied the binding site of EGFR TK, forming distinct interactions from lapatinib (Figure 7a), whereas BTP-1–10 revealed no interactions.
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PMC11451940
The most cytotoxic complexes, 1 and 5, modified the cell cycle of the A2780 cells by diminishing cells in the S phase and simultaneously increasing the number of cells in the G2/M phase, which is the behaviour previously described for a number of copper(ii) complexes, e.g. the Schiff base complex derived from S-benzyld...
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PMC11777207
Once in the lymphatic vessel, the DCs are propelled by laminar flow resulting from lymphatic muscle cell pumping in the vessels (21, 22).
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PMC3765139
Cell suspensions from melanoma cell lines were incubated with the following fluorochrome-conjugated antibodies: PE/APC-CD133, FITC-CD105, APC-CD271, FITC-CD146, and APC-CD117 (Becton-Dickinson, San José, CA, USA).
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PMC9429973
Aims: To expand on the body of data regarding TAG therapy in pediatric pts with BPDCN.
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PMC6600253
G-quadruplexes can be resolved only by DNA helicases and not by telomerase .
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PMC11632064
Cells were rinsed with water and stained with 0.5% crystal violet solution (wt/vol in 20% methanol) for 30 min.
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PMC11519567
two-sided, unpaired t test; n = 6 condensates.
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PMC11740573
of resistant strains E. coli (N = 5)Amoxicillin / clavulanic acid8642Kanamycin321281Moxifloxacin0.060.1250E.
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PMC11718109
Scale bar, 10 μm.
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PMC11055323
Two-sided Wilcoxon test adjusted for multiple comparisons.
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PMC8903741
The well was washed three times with 200 μL of TBST and developed with 100 μL of tetramethylbenzide (TMB) solution.
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PMC11467964
After that, we initiated univariate and multivariate Cox analyses to explore if the risk scores were not related to other clinical characteristics in training cohort.
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PMC11721295
Inactivation of oncogenic KRAS in tumors results in tumor regression, establishing a role for oncogenic KRAS in the maintenance of NSCLC.
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PMC11224020
To test this hypothesis, we loaded the two types of DCs with the class II ovalbumin (OVA) antigenic peptide and incubated them with OT-II transgenic T cells.
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PMC10831439
Invariant natural killer T (iNKT) cells are a small T-cell subset that plays a significant role in malignancies, infectious diseases, autoimmunity, graft rejection and alloimmunity.1–3 They are characterized by the expression of an invariant T-cell receptor.4 In contrast to conventional T cells, iNKT cells recognize gl...
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PMC11194678
Lower: FRAP recovery curve of Cy5-STAU1 by averaging signals of 17 droplets with similar sizes each after photobleaching.
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PMC11772585
Knockdown of METTL1 inhibited A431 xenograft tumor growth (C) and reduced tumor weight (D).
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PMC10898159
Our previous study showed that FTO inhibition can dramatically inhibit cell proliferation and increase sensitivity of GIST cells to IM-induced apoptosis.
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PMC11095939
After attachment, cell samples were collected at 24, 48, and 72 hr.
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PMC9352806
The mean lifespan was referred to the exact time when the survival rate reached to 50%, which was generated by the OASIS application.
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PMC9000591
Meanwhile, these fractions had trivial effects on the noncancerous cell line LCL (the percentages of apoptotic cells ranged from 12.4% to 23.5%) (Figure 3).
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PMC10914904
However, future experiments are required to examine this role.
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PMC11742231
Such integration is crucial for understanding the complex biological pathways involved in drug sensitivity and resistance.
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PMC8916024
Moreover, the relative abundances of Aeromonas and Luteolibacter in the gut of juvenile snails (30.8%, 11.8%) were also higher than those of adults (27.7%, 10.6%, Fig. 2B).
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PMC11489175
An oncogenic role for USP39 is supported by the evidence that it facilities the splicing of high mobility group A2 (HMGA2), an oncogenic co-activator of transcription 107.
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PMC11461874
In addition, overexpression of TRAF7 reduced the DBP protein levels (Fig. 4a; see below), while any of the other five E3 ligases did not (Supplementary Fig. S2), highlighting TRAF7 as a strong candidate for E3 ligase catalyzing the UBE2G1-mediated DBP ubiquitination and degradation.
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PMC11755624
The cytokine is involved in the progression of psoriasis, as it upregulates other pro-inflammatory cytokines and stimulates the infiltration of immune cells towards the skin.
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PMC8996378
Among them, compound 43 showed significant inhibitory activity on ABCB1-mediated drug efflux in KBv200 cell line (RF = 43.63) The inhibitory effect of compound 43 on ABCB1-mediated drug efflux was further tested at several concentrations by Rh123 accumulation assay.
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PMC6379402
The GEO with gene duplication model (GEO-GD) is a geometric model in which the dispersion of nodes is no longer uniformly random, but according to duplication and divergence rules, mimicking the gene duplication and mutation process in biology.
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PMC11745823
The IF for Ki‐67 was performed on the brain tumours, demonstrating that RIT1 knockdown led to reduced Ki‐67 expression relative to the control (Figure 3E).
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PMC11725127
Endogenous interaction of KRAS and USP2 was further verified in MM.1S cells (Fig. 4J).
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PMC9019892
However, approximately 50% of patients with GIST develop secondary resistance within 2–3 years of treatment with imatinib .
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PMC7171147
Lentivirus-containing media was harvested and filtered through a 0.45 µm polyvinylidene fluoride (PVDF) low protein-binding membrane filter (Celltreat) and mixed with polybrene (8 µg/ml).
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PMC4443654
We have shown that our perspectives of features occurring at different strata can be bridged by modeling approaches, and the models produced can be used to explore the interrelationships between these different features quantitatively.
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PMC7961460
Here we show that the knockdown of c10orf118 by the nucleofection of 30 nmol siRNA reduced the mRNA levels of HAS2 and its epigenetic regulator HAS2-AS1 (Figure 5B,C), whereas increased the levels of the HA receptor CD44 (Figure 5D) with respect to MCF-7 cells transfected with 30 nmol of a scrambled siRNA.
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PMC9429973
Axi-cel also showed meaningful improvement in quality of life over SOC, measured by multiple validated PRO instruments, with suggested faster recovery to pretreatment quality of life.
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PMC9429973
2021 Dec 17;13(24):6348.
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PMC9429973
Evidence comparing TH17/TReg balance between low risk MDS patients and controls is scant.
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PMC9429973
A total of 12 pts （57.1%）experienced immune-related adverse event, including rash (28.6%), pneumonia (9.5%), hypothyroidism (9.5%), elevated serum bilirubin (4.8%) and transpeptidase (4.8%), which were all resolved by glucocorticoid.
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PMC11596967
The Deinococcus genus is well known for its extraordinary resilience to ionizing radiation (IR) and possesses complex antioxidant systems designed to neutralize ROS generated by IR.
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PMC9429973
First-line treatment regimens in the early PD group included R-CHOP (74.2%), R-EPOCH (7.6%), and other immunochemotherapy (IC)(18.2%), which was similar to non-ePD patients.
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PMC8526701
Colony formation analysis confirmed that GSK602-treated cells exhibited less colony formation than control cells (Fig. 2E).
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PMC10759659
IHC staining of these tumours additionally revealed that the loss of ARID1A significantly upregulated CD8 and CD56 infiltrating levels in these tumours (Fig. 4e, f).
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PMC9966931
The results of the SGI analysis for each hybrid at three different concentrations against the selected fungi are shown in Table 2.
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PMC5673060
A one sample t-test was performed where the null hypothesis was equal to 0.
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PMC10142392
These advances have opened up new perspectives in the field of drug delivery, offering new options for the treatment of various diseases .
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PMC11683130
Transcriptome analysis showed that SerpinA8 (AGT) is one of the differentially expressed genes in mild psoriasis (17).
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PMC11711345
According to these data, among cancer cell lines with Pa ≥ 0.50 for at least one of the substances (Figure 3b), the very low Pi (≤ 0.11) implied a high Pa-Pi (0.30-0.60), leading us to consider them to have low-to-high cytotoxic activity.
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PMC11696659
Patients with chronic obstructive pulmonary disease (COPD) and smoking habit are at higher risk of lung cancer .
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PMC11291490
The anti-duck CD4 monoclonal antibody (Cat# MCA2478, Bio-rad, USA) at 1:200 dilution and the anti-duck CD8 monoclonal antibody (Cat# MCA2479, Bio-rad, USA) at 1:200 dilution were added into the cells, respectively.
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PMC9812014
It has been reported that emetine is active against this discussed pathway of infection of RABV in the N-compartment axons.
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PMC11632064
Related to Fig 2H and I. (E) Densitometric analysis of selected cytokines from conditionned media from MeWo cells and detected by cytokine array.
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PMC9429973
The engrafted cells showed a myeloid phenotype with expression of CD38, CD33 and CD14, with higher engraftment in bone marrow than spleen.
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