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OTAR3088
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PMC11610461
Metformin exerts anticancer effects by modulating the immune microenvironment (Foretz, Guigas & Viollet, 2023; Wang et al., 2020).
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PMC11001582
The statistical significance threshold was set at P < 0.05, unless otherwise indicated.
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PMC9429973
Methods: Real-world data was collected consecutively from all patients treated in the intensive treatment arm with VTD as first-line chemotherapy between January 2015 and November 2020.
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PMC10887351
In a dog model of rapid HF, correlated with increased β3-AR expression, the acute β3-AR stimulation further decreased the contractility and the transient Ca2+ of isolated ventricular myocytes from FH .
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PMC11025866
These results identify new genes that respond to NaB and VPA in HH514-16 Burkitt lymphoma cells, highlighting the prevailing effects of HDAC inhibition on cellular gene expression and the value of determining the effects of the non-HDAC inhibitor VPM on cellular gene expression by itself and in combination with butyrat...
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PMC11640247
These transitions are governed by structural changes in the Switch I and Switch II regions, which are essential for effector recognition and GTP-dependent signaling.
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PMC8978939
There are striking differences among other authors’ results regarding the absolute value of WT pVHL and variant half-lives, even if we only consider those that use the same cycloheximide concentration (50 µg/ml).
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PMC9429973
Belantamab mafodotin shows promise in treatment of relapsed AL and needs further prospective trials.
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PMC11538390
Mice were housed in the animal facility where their health, food, water, and housing conditions were monitored with daily visual checks by technicians.
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PMC9429973
Furthermore, we detected reduced p53 and Myc protein expression in Brusatol-sensitive cell lines upon treatment.
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PMC8750422
In general, the functional role of eNOS in cancer biology is not yet understood.
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PMC9622879
where is the total energy cost which all buying homes must pay for all selling homes.
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PMC11473843
Part of the anti-tumor effect of both FAKi- or FAKi + ERK5i-treated group was due to decreased proliferation as shown by the reduction in Ki-67-positive cancer cells compared to vehicle-treated group (Fig. 6E).
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PMC11046454
The results, including the weight (Figure 5C), size (Figure S42), and tissue section staining (Figure S43)) of the harvested tumor organs, all confirmed that ATP-AptPTK7-CAR-T and AptPTK7-CAR-T could effectively inhibit the tumor development, while no significant effect was obtained by Lib-CAR-T. Investigating the in v...
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PMC3931643
a. Annexin V and propidium iodide staining to assess DLBCL cell lines undergoing apoptosis following a 48* p<0.05, ** p<0.01, ***p<0.001, ****p<0.0001.
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PMC11590005
It is crucial to dismantle racial oppression in over-whelmingly white spheres such as dental schools , especially in countries such as Brazil, which have limited healthcare system resources.
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PMC11562028
The original medium was discarded, and the cells were cultured in low serum MEM medium (2% FBS) containing different concentrations (0, 30, 50, 70, and 90 μg mL) of the Re-CDs for 24 h. A microscope was used to take photographs to record the wound healing of the cells.
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PMC9895440
2nd generation lentivirus was then prepared on a larger scale (>1000 cells / guide) from the library and the NY-ESO-1 TCR, which were then concentrated by ultracentrifugation and titrated on Jurkat cells.
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PMC9429973
The most common treatment-emergent adverse events (TEAEs) included constipation (68%), thrombocytopenia (55%), anemia (52%), neutropenia (47%), nausea (46%), and diarrhea (44%).
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PMC11739696
Each sample underwent acquisition of 12,000 events, and positive FITC and/or PI cells were quantified through quadrant analysis using ACEA NovoExpress software (ACEA Biosciences Inc., San Diego, CA, USA).
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PMC11055510
SKOV3 cells are widely used in the study of ovarian cancer because of their ability to proliferate stably in vitro and exhibit typical cancer cell characteristics.
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PMC11066331
6Three-dimensional visualization of PCA of 175 mass spectra recorded from 7 binary cell population mixtures (A).
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PMC8903741
As the CHO cells secreted proteins to the extracellular medium, we collected each medium after cultivation and purified the antibodies from the supernatants by means of PA bead purification.
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PMC9429973
The construct that showed a stronger activation was tested in an in vivo model.
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PMC11499381
Where negative controls were required for imaging experiments, wells were transfected with empty vector at an equivalent total DNA per well as for receptor transfected wells.
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PMC9268620
Mitochondria transport Ca to regulate cytosolic Ca, to serve as a store of Ca when its concentration in the cytosol is excessive, to serve as a releasable source of activator Ca, and to regulate mitochondrial matrix Ca and, thereby, control the level of activation of Ca-sensitive metabolic enzymes.
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PMC6892818
5Differential regulation of TRAF proteins by mCD40L in normal (HRPT) and malignant (RCC) cells.
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PMC11682224
The cells were separated into four groups: NC, CHD1L-OE, NC, and CHD1L-KD.
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PMC11082662
This study revealed a substantial upregulation of SMPDL3B in the serum of ovarian cancer patients, correlating with an unfavorable prognosis.
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PMC11707577
Synthesis and characterization of HSA‐TM were previously reported.
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PMC9429973
Image: Summary/Conclusion: In this study, based on a HSC transplantation platform, we collected human bone marrow NK cells before and after G-CSF in vivo mobilization.
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PMC9429973
According to the treatment, the patients were divided into transplantation group and non-transplantation group.
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PMC10778532
This correlated with an overexpression of ZHX2 and a transcriptional regulation showing an enrichment of hallmarks of hypoxia and epithelial mesenchymal transition in VHL-C162F cells.
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PMC10547921
The crystals of NAMPT and compound 111 showed that the newly incorporated aniline group interacts with the backbone amide of Glu376 via a hydrogen bond, potentially offsetting any desolvation penalty for the addition of a polar functional group.
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PMC9429973
IVO+AZA was associated with preserved or improved HRQoL compared to baseline for most subscales of the EORTC QLQ-C30 from C5 to C19 (after which no placebo+AZA HRQoL data were available), and at most timepoints for EQ-5D-5L VAS scores and index values.
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PMC11285179
Moreover, a previous study has reported that CCL28 could recruit Tregs and promote angiogenesis in ovarian carcinoma .
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PMC9429973
Kappa chain type was present in 55.3% of the patients, while lambda type was detected in 44.6% of the patients.
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PMC11670407
Next, we hypothesized that the high protein expression of GPX4 induced by cisplatin is dependent on OTULIN.
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PMC11792888
The proteins were separated by denaturing sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE; 10-15%) then transferred onto a nitrocellulose blotting membrane (Amersham, Cytiva, Germany).
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PMC9429973
Rituximab (if CD20+) and prophylactic IT chemotherapy were given for the first 4 cycles.
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PMC11721587
Ptch1: GGGTTGCCTACCTGGGTGGTCT(F) and AACGCG-ATTGGCTCTTGGAG(R).
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PMC11656657
However, for sarcoma cell lines with lower GD2 expression, the efficacy of CAR.GD2 T-cells was reduced, although still better as compared to un-transduced T cells.
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PMC7519871
WDL formed 4 hydrogen bonds with Akt, whereas, BA 2 hydrogen bonds.
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PMC11499381
Additionally, we investigated ligand-dependent internalization in HEK293S cells.
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PMC9429973
Only patients which required systemic treatment were included in the analysis.
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PMC10745221
The EpiQuick Total Histone Extraction Kit (EpiGentek, catalog #OP-0006) was used to extract the histones from each cell line.
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PMC5916734
The genomic DNA to be used for Southern blotting was cleaved with ApaI endonuclease for 16 h, and the DNA fragments were separated in 0.8% agarose gel.
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PMC11711127
Also, the possibility of preventing senescence in tumour-specific T cells makes these senescent T cells potential therapeutic targets.
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PMC11770199
Cell viabilities were analyzed after coculturing for 48 h by cell counting kit-8 (CCK8).
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PMC11699042
In addition, the matching interval of the WGS data had to be 80%–120% of the CCLE interval’s size.
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PMC9429973
No correlation between BDNF and Glucosylsphingosine (Lyso-Gb1) levels was detected.
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PMC11469524
When investigating the global effect on the 3000 most varying phosphosites by hierarchical clustering (Fig 4A) and principal component analysis (Fig 4B), it is evident that α-IgM treatment had the strongest impact.
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PMC11706776
In addition, when cells were treated with 30 nM doxorubicin, KCNN1 silencing significantly increased cell response to doxorubicin.
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PMC9684669
In recent years, CAMK2 has garnered a great deal of attention for its pivotal role in the arrhythmias of chronic illness (59).
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PMC11621565
The upregulation of α-synuclein observed in response to bacterial amphiphiles introduces a novel mechanism of microbiota-induced PD pathogenesis, augmenting the established understanding of direct α-synuclein aggregation.
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PMC11194678
Confocal images were processed with ImageJ (RRID:SCR_003070).
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PMC10988555
The solutions were prepared in 5 mM Tris–HCl, 50 mM NaCl, pH 7.02, buffer, and incubated for 24 h at 37 °C.
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PMC9065483
Upon confirming that the addition of gefitinib was able to reduce vanadate viral sensitization in colon CT26WT carcinoma cells when administered pre- and post-infection in vitro (Figures S17 and S18), we found that CT26WT colon mouse tumor cores pre-treated with vanadate and treated with gefitinib 4 h prior to infectio...
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PMC9856122
For instance, BBR is a protoberberine alkaloid extracted from various species of the Berberis genus exerting antiviral activity against a diverse range of viruses including HIV, HSV, HCMV, and human papillomavirus (HPV) .
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PMC10932641
LncRNA PCGEM1 upregulates FGF2 to promote RCC cell proliferation and migration (32).
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PMC8557138
Further, a few studies have highlighted the prospective of electrical stimulation in promoting angiogenesis, however, most of these studies are preliminary in vitro studies, for instance, basic alignment studies under directional electrical fields of 150–400 mV/mm for different cell types like pulmonary artery fibrobla...
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PMC9429973
In terms of outcome, male sex, along with symptoms including MPN10, anaemia (haemoglobin<120g/L), thrombocytopenia (platelet count<100×109/L), leucocytosis (leukocyte counts>13×109/L), high LDH value (>350U/L), splenomegaly, WT1 overexpres-sion(WT1/ABL1 copies≥1.0%), KMT2A, ASXL1 and TP53 mutations, indicated a poor pr...
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PMC11786767
Therefore, Ki-67 knockdown leads to chromosome collapse and microtubule array abnormalities during mitosis.
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PMC5417661
The pharmacokinetics data are summarized in Table 1.
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PMC8996378
The results showed that compounds 71 and 72 were potent low-cytotoxic MDR modulators with greater ability to reverse MDR than verapamil on ADR resistant human breast adenocarcinoma cell line MCF-7/ADR (RF = 21.5 and 18.8 at 5 μM, respectively) (Chen et al., 2021).
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PMC11795610
At the same time, different concentrations of myricetin (15, 30, 60 μM) were administered during the differentiation induction.
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PMC6442998
Supplementary Table 6 summarizes gene expression and drug sensitivity of GIST882 and GIST48 cells.
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PMC11486946
Because TKI itself seems to have little effect on the mobility in our data, the MSD ratio (MSD with EGF to MSD without EGF) was used to evaluate the compounds en bloc.
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PMC11252553
Radiation-induced cell death can occur through two primary mechanisms: (A) mitotic catastrophe, the most common mechanism in most cell types when exposed to radiation, and (B) apoptosis, in specific types of irradiated cells, such as hematopoietic and lymphoid cells.
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PMC7452526
The analysis was done after diluting a small aliquot of the suspension into distilled water (1:4).
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PMC11201989
For analysis of ciliary assembly, cells were plated at 50–60% confluence in plates containing glass coverslips, grown to approximately 80% to complete confluency, and starved for 24–48 h (regular DMEM or DMEM/F-12 without serum) to induce cilia growth, followed by immunostaining.
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PMC10900886
The viruses included in this study with virus reference number, year of isolation an accession number are as follows: subclade A (or A1; 4311200821; 2012, accession number MN954536), subclade A2 (previously known as D; 4311400720; 2014, accession number MN954537), and subclade B2 (4311201039; 2012, accession number MN9...
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PMC11772585
To determine the expression pattern of METTL1 in cSCC, we initially examined the protein level of METTL1 in paraffin-embedded sections from 36 cSCC and 7 normal specimens by IHC.
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PMC9219615
Many of these markers for apoptosis were also evident to a comparable degree in the acute lymphocytic leukemia cell line CCRF-CEM (Figures S1 and S2).
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PMC11544122
For BRET experiments, parallel samples from the same pool of transfected cells were analyzed for cell surface expression of each GPCR.
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PMC11266100
Long-term transfected cells expressing luciferase were cultured and preserved by freezing them in a medium consisting of 10% DMSO and 90% FBS.
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PMC11742670
Following this, 70 µL of SRB solution (0.4% w/v) was added, and the cells were incubated in the dark at room temperature for 10 min.
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PMC11695623
I,J) Silencing DCUN1D5 significantly reduces subcutaneous graft tumor weight in nude mice.*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
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PMC7612475
Cells were transferred into a universal containing cell culture medium with 2 mmol/L hydroxyurea (HU), the cells were spun at 1,400 rpm for 4 minutes, the supernatant was discarded.
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PMC10956161
All statistical analyses were performed using IBM SPSS Statistics for Windows, Version 21.0 (IBM Corp., Armonk, NY, USA).
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PMC11759543
The preatment of pan-caspase inhibitors could restore a recovery rate of approximately 41 % in 5637 cells and 42 % in BFTC 905 cells.
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PMC11075223
There is often a hydroxyl group substituted at the C-15 position.
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PMC9164404
For BEL-7404 cell, the IC50 of Abplatin was much lower than that of CisPt(IV) and cisplatin.
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PMC11609529
Bioluminescent imaging of tumor-bearing mice was performed on day 17 post-tumor cell injection. (
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PMC11228511
We used mouse SMCs as a model system to better understand the mechanisms responsible for the progerin-induced NM ruptures and SMC loss in the aorta of Lmna mice (21).
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PMC11593084
Therefore, a better understanding and management of the tumor specificity of mAbs will be essential for further optimization.
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PMC9429973
Arm 2 (Dexamethasone): dexamethasone 40 mg daily for 4 days for up to 3 cycles every 14 to 28 days (DEX arm).
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PMC4277423
To analyze cell surface expression of CCR5, CXCR4 and CD4, 2×10 mock- and Cas9-HA-NLS and sgRNAs (CR1, CR2, CR3 or GF1)-transduced TZM.bl cells were incubated with a PE-conjugated mouse anti-human CCR5 (BD Biosciences), PE-conjugated mouse anti-CXCR4 (Becton Dickinson) or APC-conjugated mouse anti-CD4 (Miltenyi) antibo...
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PMC11461874
j Control and TRAF7 KO NIH3T3 cells were transiently transfected with plasmids for DN mutant of UBE2G1/UBE2T together with expression plasmids for Flag-DBP.
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PMC9429973
A. Startsev, M. Solovev, V. Dvirnyk, M. Panasenko, I. Galtseva, N. Kapranov, M. Firsova, E. Makunina, A. Abakumova, E. Mamaeva, L. Mendeleeva National Medical Research Center for Hematology, Moscow, Russian Federation (Russia), Moscow, Russia Background: Malignant plasma cells (PC) immunophenotype is well understood an...
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PMC7504302
Possible mechanisms underlying these observations included reduced expression of Cyclin D1 and Cyclin D3 and decreased phosphorylation of ERK1/2 .
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PMC11412721
We compared the proliferation and migration capacities of Raji control cells (transfected with the Cas9 expression vector without guide RNAs) and the two independent ACKR4 KO Raji clones identified, cultured for 15 hr in medium supplemented or not with the CCL21 chemokine.
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PMC8992508
However, compound 65 (R2 = 4-CF3) with an IC50 value of 0.451 M showed a maximal response comparable to that of elacridar (63) and Ko143 (5) (Imax = 100).
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PMC11675244
In a phase I clinical trial, low doses of resveratrol inhibited Wnt signaling in normal colonic mucosa but failed in cancer cells, suggesting a role in colorectal cancer prevention rather than treatment .
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PMC11271278
In this study, we focus on trans-enhancer hijacking events because they are more likely caused by structural alterations than cis-enhancer hijacking events that may be caused by other types alterations such as epigenetic loss of TAD boundaries.
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PMC11201245
The losses in 18q22 that we detected are also confirmed by Lambros et al. and Tan et al. .
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PMC11738017
Univariate analysis of sBCMA levels (400 ng or median cutoff) in the subgroup of patients with EMD. (
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PMC11627398
Additionally, Liu et al. found that GLS had good diagnostic value in acute myocardial infarction .
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PMC11604015
And no malignant cell contamination was detected in NS7CAR by FCM or qPCR .
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PMC11448304
All related experiments were conducted within the next ten passages.
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