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OTAR3088
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BioData-CellLine_annotated

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PMC7154001
Thus, this toxicity can be observed at the therapeutic dosage (75% of MTD).94 Drug metabolism plays a critical role in determining the pharmacological and toxicological effects of a drug in human.
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PMC11754432
For double siRNA transfections, 20 nM of non-targeting siRNA was used for control, with an additional 10 nM of non-targeting siRNA added to each of ALOX15B and STAT1 (M-003543-01) single transfections.
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PMC5363531
LKB1/STK11 is involved in SRC signaling , as well as in PEM response through mTOR pathway .
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PMC7642379
Here, the genomes and transcriptomes of the original HEK293 along with five progeny cell lineages were analyzed (Fig. 1a).
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PMC8409415
Mann‐Whitney U test was used to compare the groups).
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PMC10631132
CSF1R increased significantly after the mesodermal stage in relation to the hematopoietic stage in the embryoid body-based (EB) differentiation protocol B independent of the iPSC line.
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PMC11512230
The usage of structurally modified plant virus particles as a platform for drugs and delivery systems has significant potential in the development of anticancer agents.
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PMC11477621
Starting from propargyl bromide (15) (577 mg, 4.85 mmol) and 2-acetyl pyrrole (440 mg, 4.04 mmol), the title compound was obtained following the procedure previously described for compound 2a.
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PMC11683240
Collectively, all results presented above suggest that the potential mechanism of α1AT inhibition against PT may involve interfering with the interaction of the toxin with cellular receptors rather than affecting its catalytic activity.
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PMC8097906
Both compounds were further tested for its effects on cell viability and cell migration of RMA cells (Figs. 6e-g).
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PMC11188874
Average peptide length was not changed after treatment with bortezomib or the HDAC6 inhibitors (Fig. 4C).
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PMC11612508
Graphene oxide (GO) nanomaterials have shown potential in regulating the administration of chemotherapeutic medications due to their surface functionalization and toxicity.
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PMC11240052
The cells cultured in DMEM supplemented with 10% FBS (Gibco, GranIsland, NY, USA), 100 mg/mL penicillin, and streptomycin (Invitrogen).
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PMC9019892
Standard procedures of immunohistochemistry staining have been described previously .
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PMC9817179
The Wilcoxon signed-rank test and Wilcoxon rank-sum test were performed using the built-in MATLAB functions signrank and ranksum, respectively.
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PMC11802855
Following PBST cleaning, luminescence was recorded with Lumin4000 from GE, USA, and ECL reagent from BioSharp.
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PMC10380508
For statistical analysis between two samples, the unpaired two-tailed t-test was used.
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PMC11139449
The viability of these cells was assessed using the MTT method for 24, 48, and 72 hours at various NaBu concentrations (2.5, 5, 10, 25, 50, and 100 mM).
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PMC11696659
The prevalence of 5 % was chosen to represent the population of lung cancer patients within the total population at risk (e.g., asymptomatic smokers aged >55 years).
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PMC11345828
All data points are an average of at least n = 2, run in triplicate.
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PMC9429973
Methods: Mesenchymal stromal cells (MSCs) from patients with either low-risk MDS, CMML or age-adjusted healthy donors were exposed to S100A9 (1.5µg/ml) ± TASQ (10µM).
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PMC9429973
No proximal gastrointestinal bleeding and other gastropathies occurred.
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PMC11615828
5HT6‐mCh‐positive components that were not connected to the basal body were not included in the length measurement.
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PMC10092581
All derivatives were evaluated in vitro for their cytotoxic potential against a wide panel of human cancer cells derived from solid tumors, and showed to possess an outstanding activity which was, both in 2D and in 3D cancer cell systems, comparable or even better than that of the reference metallodrug auranofin.
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PMC11470381
Without the overlap, gaps remain between the endpoints of the line and the ellipse’s edges, which does not allow selecting either half of the ellipse using the Wand tool later.
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PMC11473750
A subset of these mice did not develop tumours.
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PMC7553912
Expressions of inflammatory cytokines were increased by stimulation with OSM in cultured renal fibroblasts.
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PMC11291697
Array-CGH analysis in the proband revealed a de novo copy number loss of 66.6 kb at 2q22.3, involving exons 5-6 (out of 12) of GTDC1 (RefSeq NM_001376312.2) (Fig. 1A).
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PMC10976516
Multiple pressures imposed by the immune environment during its fight against tumor formation cause the elevated expression of these ligands in human cancers (Table 2).
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PMC10958426
The chromosomal regions without detected CNVs were called noCNV regions.
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PMC11742047
Kinetic profiles of PS exposure (luminescence) and loss of membrane integrity (fluorescence) through 24 h of exposition.
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PMC10734950
F8 ability to induce apoptosis was assessed in a phosphatidylserine externalization assay and measured through flow cytometry.
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PMC11106977
Interestingly, research has shown that the concentration of IL-1a is also increased in OA joints.
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PMC11777207
Paired Student’s t test was performed to calculate the P values where **P < 0.01 and ****P < 0.0001.
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PMC10170482
The acquisition software GeneTools (Syngene, UK) for chemiluminescence reading was used.
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PMC11119602
The platinum-based antineoplastic drug cisplatin is still being used for the treatment of advanced hepatocellular carcinoma, as the sole chemotherapy drug or in combination with other drugs .
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PMC9429973
LFPRLR knockdown in SLE-prone mice also significantly reduced the expression of the activation induced cytidine deaminase (AID) enzyme, known to induce malignant transformation of B cells.
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PMC11257988
For the 330 patients with advanced KRAS-mutant lung cancer screened, the most common co-occurring genomic alterations were TP53 (42%), STK11 (29%), and KEAP1/NFE2L2 (27%), and KEAP1/NFE2L2 co-mutation was an independent prognostic factor that predicted shorter survival .
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PMC11342785
A, strategy for rewiring TPPP activity using orthogonal IDR sequences to construct synMAPs.
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PMC10919056
Apoptosis was detected with an annexin V apoptosis kit (Vazyme, Jiangsu, China).
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PMC11225860
In addition, it potentiates killing of polyploid cells, which could help limit cancer recurrence.
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PMC11746942
The genotyping primers amplified the KO fragment and wild-type (WT) fragment.
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PMC10988555
To study the effect of incubation of glutathione with our complexes 2–4 in a biological medium, UV–vis spectra of the complexes in the presence and absence of GSH after 24 h incubation at 37 °C were obtained (Figure S19).
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PMC11546117
RNA extraction was performed using TRI Reagent and the NucleoSpin RNA II kit, as previously described .
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PMC11206502
High levels of basal autophagy in 5637 cells are confirmed by LC3 immunofluorescence staining in a nutrient-rich environment.
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PMC9503669
Previous structural studies have established that HIV-1 Nef has a remarkable ability to form multiple homodimeric structures, despite a conserved fold of the core region .
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PMC11751675
However, the most active compound, 13-acetyl solstitialin A, lacks both chlorinated groups and the α-methylene-γ-lactone moiety.
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PMC11078693
Fixation reagent for 20 mL cell suspension CRITICAL: Formaldehyde is toxic, handle in a fume hood.
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PMC8711270
Despite the improvement in process scalability, retroviral vector production remains challenging.
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PMC11489175
In addition, it was hypothesized and then confirmed that USP28 was a target gene for the transcription factor TBX5 as USP28 promoter indeed contains binding sites for TBX5.
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PMC4270159
f. Wash the blots with TBS +0.5% Tween-20 four times for 15 min each.
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PMC11770746
We demonstrated for the first time that Pt(IV) complexes, as simple prodrugs for cisplatin or oxaliplatin, or as multitargeting prodrugs, do not induce neuropathic pain in male or female mice.
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PMC9429973
Among pts who received RUX, fewer thrombocytopenia events were observed among those treated earlier (≤12 mo vs >12 mo), with differences seen as early as Wk 4–8 on treatment (18% vs 33%) and sustained over time; a similar trend was observed for anemia events (Wk 4–8, 59% vs 72%).
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PMC11640115
Therefore, TMB is often measured after an ICI regimen is administered and is rarely used as a pretreatment indicator in clinical practice .
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PMC11204465
In 1961, it was found that peanut cake contaminated with Aspergillus flavus could induce liver cancer in rats, and in 1962, AF was identified and proved to be a strong carcinogen.
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PMC11775197
Early studies have shown that PPARα agonists reduce transcriptional activation of COX-2 and VEGF, which are associated with tumor angiogenesis .
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PMC11424574
After cell lysis in NETN lysis buffer, samples of total protein (20 μg) were electrophoresed for 1 h and transferred to a PVDF membrane for 1 h. The membrane was incubated in blocking buffer for 10 min, followed by incubation with primary antibody against MTA2 (1:1000), p-ERK1/2 (1:1000), t-ERK1/2 (1:1000), uPA (1:1000...
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PMC9429973
PTCL subtypes were AITL n=33 (41%), PTCL-NOS n=32 (40%), ALK- ALCL n=14 (18%) and EATL n=1 (1%).
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PMC10873328
Despite the development of OC treatment strategies, the overall 5-year survival rate for OC patients remains only 49% for all races and 24% for advanced patients.
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PMC7229095
We attempted to adapt CHO-DG44 cells already adapted to CDM1 to these media, and cells only failed to adapt to CD FortiCHO (data not shown).
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PMC9429973
This constitutes a novel and promising therapeutic approach that could help overcome the current drug resistance in haematological neoplasms currently found in the clinic.
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PMC8996378
The most common drug-resistant cell lines involved in this review are HepG2/ADR and MCF-7/ADR cell lines.
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PMC9388315
As shown in Figure 4(b), the level of HSF1 in 2.50 (P < 0.05) and 5 mg/ml (P < 0.01) was significantly decreased.
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PMC10419319
The mechanism of cisplatin resistance is extremely complex and multifactorial.
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PMC10507284
It is well known that the prognosis of cancer is often related to multiple risk factors.
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PMC10729469
Fig. 3Adoptive transfer of TCRAβ-Tregs improve memory function in APP/PS1 mice.
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PMC11052306
Both compounds displayed relatively low toxicity towards EPC cells, but deceptively, the gold complexes are highly toxic toward the MRC5 cells.
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PMC9429973
One of the main manifestations of MM is the lesion of the skeleton bones, which may already manifest at the stage of MGUS and SM and further it can lead to a decrease in the quality of life of patients.
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PMC10955424
In the presence of malignant ascites, crizotinib was effective in restoring platinum sensitivity to OC (Fig. 4).
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PMC10376064
25–35 °C).
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PMC9429973
Hemojuvelin (HJV) is a glycosylphosphatidylinositol-anchored membrane protein expressed in iron-loading tissues that binds Bone Morphogenetic Protein (BMP) family ligands as a central regulator of hepcidin expression.
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PMC6222726
Fruits are 7.5 to 12 mm long with a black pit almost or completely covered by a yellow or orange pseudoaril.
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PMC4270159
0.001 µM–10 µM erlotinib + no ligand.
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PMC10094712
These changes in the redox status can significantly affect the correct folding of proteins in the lumen of the endoplasmic reticulum, which leads to the accumulation of misfolded proteins and is the cause of ER stress activation.
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PMC11283030
Further analysis demonstrated that p-AKT (S473), instead of pan-AKT, Raptor and GβL, was decreased in ACLY knockdown 786-O and A498 cells (P < 0.001, P = 0.018, respectively, Fig. S7).
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PMC9429973
Bionano Genomics Rare Variant Pipeline (RVP) was used for somatic variant detection.
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PMC11593031
Thus, similar results obtained for studies using Neuro-2a and C1300, for example, in a study from 2011 , are not surprising.
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PMC9429973
Severe SCD patients with ≥5 VOCs represent a significant burden on payers.
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PMC10898159
Once CTCF insulator displaced by DNA methylation, allowing the super-enhancer to contact and induce KIT Gene and epigenetic regulations of KIT expression in GIST.
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PMC11225860
To investigate the effect of Aurkin A to inhibit alisertib induced polyploidy in vivo, we utilized a VAL xenograft model.
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PMC10849234
Where indicated, statistical significance was determined using a one or two-tailed student’s T-test, or three-way ANOVA as indicated in the figure legends, where * indicates p<0.05, ** indicates p<0.01, and *** indicates p <0.001.
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PMC11551844
The cell lines TERA1, A172, CCD18Co and DLD1 were obtained from Cellonex, Randburg, South Africa.
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PMC9817179
The knock-in A673 cell line showed a 100% match with A673.
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PMC6450504
Cells were treated either continuously for 48 h in serum-complete medium (HeLa) or treated for 4 h followed by 44-h incubation in complete fresh medium (A2780-ADR).
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PMC10344560
Black debris inside the PD catheter and removal of the catheter.
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PMC11476264
The agarose beads–antigen–antibody mixture was washed thoroughly with RIPA buffer, and Western blot analysis was conducted with indicated antibodies.
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PMC11539788
IHC analysis of RNF19A expression in normal and BCa tissues.
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PMC11541409
Journal of Clinical Oncology, 2023.
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PMC11409031
The hdWGCNA algorithm was utilized to elucidate the molecular characteristics of essential fibroblast modules.
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PMC9429973
Aims: To address these limitations, pirtobrutinib, a highly selective, non-covalent BTKi that inhibits both wild type (WT) and C481-mutated BTK with equal low nM potency was developed.
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PMC11093197
In most cases, quiescent cells arrest at the G0 phase, a phase distinct from the G1 or S phase.
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PMC9429973
Summary/Conclusion: Our study confirms the prognostic impact of EPs percentage in BM on OS and demonstrate notable differences in their mutational profile.
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PMC11348300
While the impact of these tracers has been limited as a diagnostic agent, the impact of PRESTO guidance as an interventional or surgery guidance tool could be much more logistically useful in point-of-care settings where there is interaction between the physician and the tissue being inspected.
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PMC10882807
Unfortunately, previous studies mainly focused on circRNAs serving as miRNA sponges.
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PMC10040136
The half maximal inhibitory concentration (IC50) of Imatinib on GIST-882 cells increased from 49.4 µM to 142.9 µM after the addition of the CM (Fig. 3L).Fig.
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PMC11732628
no. 12789-1-AP; 1:2,000; Proteintech, Wuhan, China), Bax (cat.
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PMC3035438
The intronic region digested by BseRI was replaced by the human IgHG1 region from H to CH3 and a selectable marker.
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PMC9429973
Furthermore, we combined NGF results with functional imaging: MRD-negativity on both NGF and functional imaging (double-negativity) was achieved in 45% of patients.
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PMC8557138
In recent years, advancement in cell and tissue engineering has led to the development of organoid models, which are constructed by depositing heterogeneous cell types in a pre-defined matrix of biomaterials (Gupta et al., 2018).
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PMC11725127
Data are mean ± SD, P-values were analyzed by one-way (n = 3) (F, G) or two-way (n = 5) (C, D) ANOVA.
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