Datasets:
OTAR3088
/
BioData-CellLine_annotated

Dataset card Data Studio Files
xet
 Community
1
PMCID
string
Sentences
string
ner
list
PMC11139449
The CHO cell line is preferred for biopharmaceutical production due to its superior protein modification capabilities ( 17 ).
[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "CHO", "cell", "li...
PMC11267830
Upon disease onset, as measured by bioluminescent imaging, the mice were intraperitoneally injected with either 12.5 mg/kg indisulam or vehicle (1% DMSO) (n = 6/group) once daily for 5 days on and 2 days off.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
In a real-life setting, RT was safely omitted in the vast majority (91%) of patients with EOT-PET D5PSS-1-4 with only 2% treatment failure.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5025404
CHO-DG44-derived cell lines producing mAb were developed using two strategies, one based on individual clones and the other based on cell pools.
[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11560255
Based on this study, PMBE is predicted to have dose-dependent antiproliferative or cytotoxicity effects on the HeLa cell line through the intrinsic pathway apoptosis mechanism.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767817
The data revealed that both concentrations of MK-2206 similarly decreased cell viability.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "data", "revealed", "that", "both", "concentrations", "of", "MK-2206", "si...
PMC11792766
Commission Regulation (EU) 10/2011 outlines specific testing conditions for evaluating the safety of plastic FCMs.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Commission", "Regulation", "(", "EU", ")", ...
PMC10870498
The results demonstrated that KIF23 interacted with SIRT7, but could not interact with KAT3B and KAT2A in HEK-293T cells (Fig. 3D and E).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "...
PMC10988808
Deactivation of these upstream kinases facilitates the movement of YAP into the nucleus of the cell, triggering the activation of genes downstream.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Deactiv...
PMC10565698
Most circRNAs are composed of exons, are evolutionarily conserved, and may be expressed explicitly in a given tissue.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Most", "circRNAs", "are", ...
PMC10976516
On the other hand, oncolytic VSV, NDV, and VV induce vasculature disruption to enhance tumor destruction, but this may limit the ability of intravenously delivered CAR T cells to reach the targeted tumor cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754291
Following three brief rinses, membranes were washed five times for 10 min each in TBS-T. Secondary antibodies, including goat anti-mouse [62–6520] (Invitrogen, 1/10,000 dilution) and goat anti-rabbit [65–6120] (Invitrogen, 1/10,000 dilution), were applied with agitation for 1 h at room temperature, followed by identica...
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11741577
Wound area was monitored through imaging on days 1, 3, 6, and 12 (Fig 3A).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Wound", "area", "was", ...
PMC10538569
For example, Mooruka et al. showed that in a BLT humanized mouse model HIV-1-infected T cells in lymph nodes through virological synapses.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", ...
PMC11453018
Differential gene expression (DGE) analyses revealed a pronounced predominance of downregulated genes over upregulated ones, in a ratio of 4:1, indicating widespread transcriptional repression induced by the treatment (Fig. 3B).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
A. Van Vuren, J. Kerkhoffs, S. Schols, A. Rijneveld, E. Nur, D. Peereboom, Y. Gandon, P. Welsing, R. van Wijk, R. Schutgens, W. van Solinge, J. Marx, T. Leiner, B. Biemond, E. van Beers Center for Benign Haematology, Thrombosis and Haemostasis, Van Creveldkliniek, University Medical Center Utrecht, Utrecht; Department ...
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11098378
We have used this approach previously to identify the host substrates of other IpaH members .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "have", "used", "this", "approach", "previously", "to"...
PMC7369657
As a result, caspase-9 triggers executioner caspases for instance caspase-3, which helps in nuclear DNA split and seizing up of the cytoskeleton and nuclear lamina, forcing cells to presume an apoptotic, spherical structure.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9065483
Mice were then injected intratumorally with vanadyl sulfate (50 mg/kg) ± gefitinib (100 mg/kg) for 4 h. Mice were then injected intratumorally with VSVΔ51-FLuc (1e8 pfu/tumor).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8358006
Analysis used genes meeting an FDR q < 0.05 threshold.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Analysis", "used", "genes", "meeting", "an", "FDR", "q", "<", "0.05", "threshold", "." ...
PMC9429973
Aims: The aim of this retrospective study is to analyze the prognostic value of baseline [F]FDG-PET/CT metabolic parameters in untreated MCL.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", ...
PMC4112127
However, amplification of stromal DNA would be expected to dilute the methylated copy number, which remained substantial and significant in comparison to control tissues.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10158546
Fluorescence of GFAP, PrP and TUBB3 was normalized to the fluorescence of DAPI. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fluorescence", "of", "GFAP", ",", "PrP", "and", "TUBB3", ...
PMC11782780
Results: EBF3 was downregulated in BC tissues and cells, and overexpression of EBF3 repressed the glycolysis capacity of BC cells, thereby suppressing stem-like phenotype.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11345828
The title compound (190 mg, 36% yield) was prepared following General Procedure F using ethyl (R)-7-(7-chloro-10-(3-(4-chloro-3,5-dimethylphenoxy)propyl)-4-methyl-1-oxo-6-(2,4,6-trimethylpyrimidin-5-yl)-3,4-dihydropyrazino[1,2-a]indol-2(1H)-yl)-4-ethoxy-5-hydroxy-1-methyl-1H-indole-2-carboxylate (495 mg, 0.61 mmol, 1.0...
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9813422
The circularized viral chromosome is not integrated into the host genome and retains genomic stability while allowing the expression of a few viral genes essential for replication.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11682525
While several feasible mechanisms can be proposed for this observed effect, they were not evaluated in the present study.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "several", "feasible...
PMC11206502
HB significantly inhibits tumor growth in vivo, regardless of the means of application .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HB", "significantly", "inhibits", "tumor", "growth", "in", "vivo", ...
PMC11352877
TGF-β1 represents apoptotic processes linked with extracellular matrix decomposition during vessel growth.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TGF-β1", "represents", "apoptotic", "processes", "linked", "with", "extracellular", "m...
PMC10818573
Additionally, EBV, a herpesvirus that widely circulates in society, may also be introduced into cells by operators who carry EBV themselves due to inadvertent manipulation, resulting in cellular virus contamination.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594074
MDA-MB-468 breast cancer cells at a density of 3 × 10 cells/well were seeded in an 8-well slide chamber and incubated for 24 h. The cells were then treated with 0.5 × IC50, 1 × IC50, or 2 × IC50 of compound 4 and incubated again for 24 h. DMSO was used as a negative control.
[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Before the trial, the expression of CD7 antigen in tumor tissue was positive confirmed by pathology.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Before", "the", "trial", ",", "the", "expre...
PMC9878278
We further examined the effect of BMP6 on the antiviral response and found that while the expression of key ISGs did not change drastically at 48 hpi (Figure 6D), the mRNA levels of MXA and IFIT1 increased significantly in BMP6 treated SC at 120 hpi by almost 3–4 fold (Figure 6E).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10874773
Since 1952, more than 140 SPS have been reported and classified into six subtypes based on their core carbon framework and functional groups: anisatin, majucin, minwanensin (floridanolide), pseudoanisatin, pseudomajucin, and cycloparvi-floralone (Liu et al., 2020, Yin et al., 2012, Zhu et al., 2009).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10606998
The experimental procedure for the study of the dose dependence of X-ray irradiation effects on the viability of the A-172 and Gl-Tr cells cultured without and with SPIONs is described in Section 4.8 and Section 4.9.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "...
PMC9164404
A Abplatin was prepared by the physical encapsulation of a hydrophobic CisPt(IV) with HSA.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "Abplatin", "was", "prepared", "by", "the", "physical",...
PMC10926885
We scratched the cells in a straight line using a sterile 200‐μL pipette tip.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "scratched", "the", "cells", "in", "a", "straight", "line",...
PMC11679033
High tail intensity values in a certain proportion of CIT-treated cells mean that some cells with higher levels of DNA damage possibly may not be able to completely remove the resulting damage through their repair mechanisms, which could lead to mutations and increased cytogenetic risk.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11759543
Apoptosis (pink box) and other unknown pathway(s) (green box) but not ROS are involved in the death mechanism.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Apoptos...
PMC6617630
A limited anti-proliferative effect was seen with the low doses of these inhibitors on these cells and did not reach to LD50 (Additional file 1: Figure S1).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11627398
Numerous studies have shown that specific blood parameters, such as C-reactive protein, procalcitonin and neutrophil to lymphocyte ratio, provide significant diagnostic and prognostic value for infectious diseases [32–35].
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11155445
IC50 values of compound (147) were lower, 26.23 and 30.9 ppm for AChE and BChE, respectively but higher for α-amylase and urease enzymes (160.33 and 91.5 ppm respectively).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9964654
The drug loading content reported for auranofin-loaded nanoparticles was in the range of 1.8–6.2 mg of auranofin per gram of NPs as compared to 35.29 mg of [Au(cdc)2] per gram of micelles for formulation AS6.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11745823
Hypoxia‐inducible Factors (HIFs) are part of the basic helix–loop–helix Per‐Arnt‐Sim (bHLH‐PAS) transcription factor superfamily.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hypoxia‐inducible"...
PMC11748363
The mechanism of their nonspecific cytotoxic effect must be the subject of future investigation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mechanism", "of", "their", "nonspecific", "cytotoxic", "effect"...
PMC9268620
In two treatments (3 and 1 μg/mL of damnacanthal), the percentages of viable cells were considerably high, and there were no significant differences in the percentages of apoptotic and necrotic cells compared to the untreated culture.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10218459
Following the 45-min incubation, fluorescence was measured using the TECAN multimode plate reader at 495Ex/535Em.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Following", "the", "45-min", "incubation", ",", "fluor...
PMC11551844
The theoretical yields of AuNPs-JDH, AuNPs-JDE and AuNPs-JC-2—assuming full conversion of the initial mass of JDH, JDE and JC-2—with respect to HAuCl4·3H2O used were 6.61 mg, 4.75 mg and 6.02 mg, respectively.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5810978
This was likely due to the degradation of tissue.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "was", "likely", "due", "to", "the", "degradation", "of", "tissue", "." ] } ]
PMC9693627
Next we decided to figure out how the absence of PTCD2 affects the functionality of mitochondria.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", "we", "decided", "to", "figure", "out", "...
PMC11699178
Subsequently, the cells were incubated for 1 h, and the optical density of the cells was measured at 450 nm .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ...
PMC11532793
Other options in Salmon were left as default.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Other", "options", "in", "Salmon", "were", "left", "as", "default", "." ] } ]
PMC8427838
Post translational acetylation of tubulin stabilizes MTs and plays a central role in its dynamic features and cellular functions, a process exploited by anti-tumor agents such as Taxol to promote mitotic arrest and cell death .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6889484
Previous gene therapy studies have proposed to utilize A3G to block HIV-1 replication by inhibiting A3G ubiquitination, increasing virion incorporation of Vif-resistant A3G mutants, expressing an HIV-1 Vif-resistant African green monkey A3G, and using an inducible promoter to block expression of A3G in the producer cel...
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11365427
A receiver operating characteristic (ROC) curve of phenylalanine was conducted and revealed that phenylalanine levels in PB plasma can effectively distinguish MM patients from the healthy population, exhibiting good specificity and sensitivity.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11467964
Relationships between clinicopathologic characteristics and the two gene subtypes. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Relationships", "between", "clinicopathologic", "characteristics", "and", "the", "two", "gene", "subty...
PMC11629143
B–D) ChIP data showing enrichment of RNA polymerase II S2P (B), BRD4 (C), and CDK9 (D) at the CMV promoter and an intergenic region. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9635307
This was supported by our biochemical analysis of the same A20 transfectants.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "was", "supported", "by", "our", "biochemical", "analysis", "of", "the", ...
PMC11538390
Stained embryos were visually assessed and embryos with no staining at all were excluded from the analysis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Stained", "embryos", "were", "visually", "assesse...
PMC11683240
In addition, α1AT treatment caused no change to B. pertussis-induced lung pathology in comparison to B. pertussis-infected and vehicle-treated mice (Fig. 13D).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11271278
This enables us to determine whether the enhancers are in the same genomic region as the HAPI gene or are hijacked from other genomic regions likely through structural alterations (Fig. 2A).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Pts responding to induction did not reach median OS, while refractory pts had a median OS of 9 months.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pts", "responding", "to", ...
PMC10093184
They differ in their growth kinetics, migration/invasion capacities, expression of selected genes and microRNAs related to cell migration, invasion, and cellular checkpoint control, but also possess common attributes of OS cells such as mesenchymal origin, ALPL, p53, and KPNA2 protein expression, and multicellular sphe...
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Methods: This study was a cross-sectional primary data collection NIS focused on disease that enrolled 242 patients with confirmed SCD diagnosis who signed patient consent forms.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11453018
The upregulation of MCL-1 could attenuate the effects of BCL-2 inhibition, potentially accounting for the reduced synergy observed with P300/CBP inhibitors .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "upreg...
PMC10669128
They also observed that among the 189 histotypes listed in the WHO classification, only 45 have corresponding cell lines .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "also", "observed", ...
PMC9429973
A. Alonso Calleja, F. Schyrr, S. F. Lopes, S. Gebhard, R. Sarkis, A. Oggier, O. Naveiras SV, EPFL; DSB, UNIL; Service de Psychiatrie de l’adulte, CHUV, Lausanne, Switzerland Background: Hematopoietic Stem and Progenitor Cells (HSPCs) reside in the hematopoietic niche, a structure that regulates the balance of cellular ...
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10589262
However, this mechanism might be disadvantageous for cancer cells because of the loss of driver oncoproteins, such as MT-KIT .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "t...
PMC11705862
Similarly, IRIS-2 protein levels were higher in differentiated cells, as shown by Western blotting (n = 6).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similarly", ",", ...
PMC9776316
Then, cisplatin or PBS was used to treat the cells for 48 h. After the treatment, 4% paraformaldehyde was used to fix cells, which then were permeabilized with 0.5% Triton X-100 for 10 min, blocked with normal goat serum for 30 min, and incubated with Alexa Fluor 488-conjugated anti-phospho Histone H2A.X (Ser139) antib...
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11380454
Blast cells were first identified by CD45/SSC gating in all patients with AML as described by Lacombe and colleagues 41.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Blast", "cells", "were", ...
PMC11380329
Blue nodes represent similar metabolites between Egyptian and French propolis, and pink nodes indicate metabolites common between German and French propolis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Blue", "node...
PMC6627640
Importantly, repression of H3K27 methylation with the EZH2 inhibitor GSK-126 conferred cisplatin resistance to parental cells while induction of H3K27 methylation with the histone lysine demethylase inhibitor GSK-J4 resulted in increased cisplatin sensitivity to resistant cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
After obtaining informed consent, eligible pts will undergo leukapheresis for PHE885 manufacture.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "obtaining", "informed", "consent", ",", "eligible", "pts", "will",...
PMC7229095
Cell density was measured using a CEDEX HiRes Analyzer (Roche, Mannheim, Germany) to calculate cell-specific productivity from the Octet QKe results.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11752767
On top of optimizing the multiple sources of NK cells, the maintenance of NK cells in circulation became a major concern for further application.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11026382
As a result, a significant fraction of designs could fail simply because they are not properly matched in terms of velocity to the surrounding pathway.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973
Unique molecular identifiers (UMIs) within probes enabled computational correction of sequencing errors to significantly increase precision of variant calls.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Unique", "molecular", ...
PMC11509224
When tested against a CQ-R Plasmodium falciparum W2 strain, it showed an IC50 value of 0.60 µM. In vitro antituberculosis screening against Mycobacterium tuberculosis H37Rv revealed an MIC value of 15.3 µg/mL. Preliminary KB assays against E. coli revealed that, at a concentration of 150 nM, monamphilectine A possesses...
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11528603
At the 36-hour time point, however, spindle-shaped HL60 cells exhibited both hall marks of apoptosis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "the", "36-hour", "time", "point", ...
PMC9429973
The principal indications (69.5%) were Acute Myeloblastic Leukemia and Myelodysplastic Syndrome and the median time from diagnosis to transplant was 7 months.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11411131
Unknown mechanisms, possibly related to protein quality control, might enhance Sec incorporation efficiency for other selenoproteins in different contexts.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Unknown", "mechanisms",...
PMC11803149
We found that ACT with young CD8 TCR-T cells effectively reduces tumor growth in young mice, whereas ACT with aged CD8 TCR-T cells fails to control tumor growth in both young and aged mice.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594074
Interestingly, compound 4 induces the luciferase signal with a 2.7-fold change at 10 μM after 24 h of treatment (Figure 7).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973
The apoptosis was confirmed also at protein levels by a trend of caspase 9 and PARP cleavages upregulation at 48h.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "apoptosis", "was", ...
PMC10502403
For mitochondrial phenotype assessment, MitoTracker Green (Invitrogen) and tetramethylrhodamine (TMRM) (FUJIFILM) were used.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "mitochondrial", "phen...
PMC11543885
Remove the final wash and leave the plate uncovered in the hood for around 2 h to dry.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Remove", "the", "final", "wash", "and"...
PMC11678130
Neither solvent, DMSO or ultrapure distilled water, used for the solubilization of the test compounds had any impact on the A375 cell viability; this was the reason why the data were normalized to the control (untreated cells).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11686380
Cranial magnetic resonance imaging (MRI) showed no malformations (Fig. 1B).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cranial", "magnetic", "resonance", "imaging", "(", "MRI", ")", "...
PMC7802142
Finasteride was associated with rare complications of decreased libido , gynecomastia and psychologic impairments .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finasteride", "was", "associated", "with", "rare", "complications", "o...
PMC11750165
It was confirmed that insertions and deletions (indels) were constructed through the sgRNA, and PEX1 could be successfully destroyed by the CRISPR/Cas9 system in zebrafish.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11574029
For transient transfection, NOTCH3 small interfering RNAs (si-NOTCH3#1, si-NOTCH3#2, si-NOTCH3#3) and SPP1 small interfering RNAs (si-SPP1#1, si-SPP1#2) were synthesized by GenePharma (Suzhou, China).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11699042
The initial pre-processing of the raw methylation was performed in R version 3.3.1.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "initial", "pre-processing", "of", "the", "raw", "methylation", "was"...
PMC11300639
TSC1 is a key gene in the tuberous sclerosis complex (TSC).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TSC1", "is", "a", "key", "gene", "in", "the", "tuberous", "sclerosis"...
PMC11528603
Besides being highly lethal against cancer cells, a potential extract must demonstrate relatively low cytotoxicity toward non-cancer cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Besides", "being", "highly", "let...
PMC10810426
Moreover, knockdown of several nucleoporins (NUPS) implicated in HIV trafficking across the nuclear envelope dramatically reduced the appearance of integrated MLV DNA in DCs but not NIH3T3 cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
All non‐APL AML cells had low or no NKG2DL surface expression, while most APL cells expressed high NKG2DL levels.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "non‐APL", "AML", ...
PMC9429973
In the FL cohort 5 (33%) had normal and 6 (40%) a complex karyotype; 3 had other.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9454852
Another resident protein in the ER membrane is the translocon (TLC), a protein complex that in physiological conditions works as a protein-conducting channel; it is not clear if it plays a role in the basal ER Ca regulation permitting Ca leakage.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11591052
We treated C2C12 and NIH3T3 cells with 0.1–100 µM of 20E for 4 h, followed by a 30 min incubation with puromycin and Western blot with anti-puromycin antibodies.
[ { "tags": [ "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...