OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC9454852	To prove its involvement in the generation of the [Ca]i peak after the BOLD-100 addition, the confocal time-lapse observation was repeated in the presence of 200 µM anisomycin (30 min pretreatment), that inhibits the ER Ca leak through TLC .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11786704	The results showed no significant lesions or damage in these organs 15 days after injection of PC capsules compared to the control group (Fig. 7E), further indicating that PC capsules possess great biocompatibility.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Daratumumab (DARA), a human IgGκ monoclonal antibody targeting CD38 approved for treating multiple myeloma, has shown preclinical efficacy in ALL models.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11732628	All the experiments were repeated three times.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "the", "experiments", "were", "repeated", "three", "times", "." ] } ]
PMC9429973	Notably, long-term safety and impact on patients’ QoL were reported by 38.6% and 34.3% of physicians, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",...
PMC5854676	R.S. Kumaran investigated MgO nanoparticles (NP) with 20 nm size via the GST and ROS gene mechanism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "R.S.", "Kumaran", "investigated", ...
PMC11694625	Reactive oxygen species (ROS) play the essential role in regulating immune responses, including anticancer, antibacterial and antiviral responses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Reactive", "...
PMC9429973	Most frequently reported AEs were manageable cytopenia and folliculitis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Most", "frequently", "reported", "AEs", "were", "manageable", "cytopenia", "and", "folliculitis", "." ]...
PMC11139449	To identify any possible off-target sites, determine the number of mismatches, and evaluate the size of these mismatches, Cas-offinder software (http://www.rgenome.net/cas-offinder/) was used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8992508	In this way R-verapamil, VX-710 (biricodar) and PSC-833 (valspodar were obtained.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "way", "R-verapamil", ",", "VX-710", "(", ...
PMC7570809	were grown in RPMI with added heat-inactivated 10% FBS (fetal bovine serum), 2 mM glutamine, 100 U/mL penicillin and 100 µg/mL streptomycin (Euroclone, Milan, Italy).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11116779	A standard curve with H2O2 concentrations in the 0–100 μM range was constructed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "standard", "curve", "with", "H2O2", "concentrations", "in", "the", ...
PMC10698968	Notably, as other research groups noticed, we reported the presence of large, rare multinucleated cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",", "as", "other", "researc...
PMC9429973	NGS at MDS dx showed more frequent TP53 mutations in t-MDS than in de novo MDS (73% vs 36%, p=0.003).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10988808	Additionally, the potential of CCDC25 as a prognostic marker warrants comprehensive validation in larger, multicentric cohorts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "the", "potential", ...
PMC11499955	Most of the [F]6 uptake remained on the tumor even 4 hours post-injection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Most", "of", "the", "[F]6", "uptake", "remained", "on", "the", "tumor...
PMC10808409	TPGS is commonly used in formulating drugs used for cancer therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TPGS", "is", "commonly", "used", "in", "formulating", "drugs", "used", "for", "cancer...
PMC10998613	β2AR exhibited a modest degree of cross-correlation in COS-7 and MDA-MB-231 cells (Fig. 3B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "β2AR", "exhibited", "a", "modest", "degree...
PMC6771295	p < 0.05 was considered to be statistically significant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.05", "was", "considered", "to", "be", "statistically", "significant", "." ] } ]
PMC9874064	Data were retrieved from TCGA datasets (http://gepia.cancer-pku.cn/).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "were", "retrieved", "from", "TCGA", "datasets", "(", "http://gepia.cancer-pku.cn/", ")", "." ] ...
PMC10582049	These results indicate that ADH1B low samples are characterized by significantly more active inflammatory processes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "indicate", "that", "ADH1B", "low", "sam...
PMC11397654	It was also demonstrated that 36 had low in vivo cytotoxicity, while the enhanced tumour suppression observed with 36-methotrexate was most likely due to synergy between the compounds, which was further proven by flow cytometric analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Although APL is considered a highly curable disease, early deaths (EDs, death within 30 days) due to coagulopathy and bleeding diathesis remain a significant challenge.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11185260	Cell cycle analysis of BT-12.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "cycle", "analysis", "of", "BT-12", "." ] } ]
PMC11670407	Different groups have reported that OTULIN deficiency can lead to severe autoinflammatory diseases called OTULIN-related autoinflammatory syndrome (ORAS, also termed otulipenia) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Aims: To determine the efficacy and safety of oral thalidomide combined with cyclophosphamide and dexamethasone (TCD) regimens in the treatment of recurrent/refractory LCH among adult patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9954564	For developing a model, 9/10th of the data is employed, and a classification error is estimated at the end.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "developing", ...
PMC11011837	Untargeted metabolomics analysis allowed the annotation of 126 polar metabolites: complete information is listed in Table S1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Untargeted", "metabolomics", "analysis", "al...
PMC11597291	PCT quantification was based on a calibration curve with R = 0.9976 and limit of quantification 0.01 μg/mL, with the linear part of the standard curve being from 0.01 to 100 μg/mL. The dispersion solution for PCT quantification was D-H2O:MeOH = 60:40 in %v/v.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11476837	Moreover, cells increased ROS in a similar manner when RA and ML-385 were used at a concentration of 5 μM in response to doxorubicin (p < 0.001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11547917	Also, a calibration curve with Trolox concentrations ranging between 0.25 mg/mL and 31 µg/mL was made to calculate the concentrations of cell samples, based on the formula below:T-AOC = (A734-b) ÷ a ÷ No. of cells × f Y—Acontrol–ATrolox; x—concentration of standard; a—slope of standard curve; b—intercept of standard cu...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7369657	Samples were fixed in 10% formalin for histopathological analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Samples", "were", "fixed", "in", "10", "%", "formalin", "for", "histopathological", "analysis", ...
PMC11768927	Overall, clinical trials employing VSV as a therapeutic agent substantiate its potential as an effective oncolytic virotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overall", ",", "clinical", "trials", "...
PMC11748335	C A heatmap showing the top 20 significantly enriched GO terms for the genes associated with each group of peaks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", "A", "heatmap", "s...
PMC11489175	Inhibition of migration of ovarian cancer cells following knockdown is also observed upon interference with USP48, another USP that has been investigated in this disease 108.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11695623	The accuracy of the nomogram model was validated by comparing the predicted probabilities of the calibrated fold plots with the observed actual probabilities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11469524	Since in our data instead of an attenuation we observe an upregulation of MEK phosphorylation in cells that show the p38 crosstalk when treated with p38 inhibitor (Figs 2F, 3A and 5A), we postulate that the crosstalk must act on or upstream of MEK.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3765139	Evidence of the capacity of CSCs to grow in spheroid structures has been repeatedly reported (refer to Introduction and Materials and Methods).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Recent studies have characterized the chromatin landscape of non-stereotyped CLLs and normal B cells (Beekman, et al. Nat Med.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recent", "studies", ...
PMC11621493	PLA2G4D catalyzes the transfer of fatty acids between phospholipids. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PLA2G4D", "catalyzes", "the", "transfer", "of", "fatty", "acids", "between", "phospholipids", "....
PMC10919056	Genetic or acquired changes in connexin proteins are closely related to cancer (27).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Genetic", "or", "acquired", "changes", "in", "connexin", "p...
PMC11470999	Similarly, Transwell assays showed that rescue of CIP2A reversed the reduction in migration inhibition by PF in CIP2A knockdown cells (Figure S5E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11543853	The dashed rectangle indicates the position of the area shown at higher magnification in panel B. Scale bar 200 nm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "dashed", "rectangle",...
PMC10582049	Expression of ECM proteins in the samples with low (n = 105), intermediate (n = 209), and high (n = 105) expression of ADH1B (TCGA dataset).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3203927	The quantity of mRNA isolated from each sample was determined using absorption at 260 and 280 nm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "quantity", "of", "mRNA", "isolated", ...
PMC11731614	The average spectral counts for RD and HFD were used to obtain a HFD/RD fold change.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "average", "spectral", "counts", "for", "RD", ...
PMC3122064	The role of p53 and MDM2 in cisplatin-induced apoptosis has been investigated using cisplatin-sensitive and -resistant human TC models.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "role", "of", "p53", ...
PMC11789597	Thus, genes involved in NK cell activation or inhibition in CAV1‐deficient MM cells were analyzed after RNA sequencing (Figure 2A; Figure S3A, Supporting Information).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10582049	A droplet-based scRNAseq method (10× Genomics) was used to perform a comprehensive analysis of the CAF population in the tumor microenvironment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11397654	Moreover, calixarene was able to suppress the signal transduction of the Mer and AXL tyrosine kinase receptors, which are overexpressed in this type of cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8345486	The doxorubicin HCl, gemcitabine HCl, and carboplatin were dissolved in H2O at 25 mM concentration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "doxorubicin", "HCl", ",", "gemcitabine", ...
PMC10154881	not significant, Welch's t‐test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "not", "significant", ",", "Welch", "'s", "t‐test", "." ] } ]
PMC11532793	Gibbs sampling slightly increased the total analysis time of edgeR as a side effect of including more transcripts in the statistical analyses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gibbs", "sam...
PMC9429973	Twenty (54.1%) and 23 (62.2%) of 37 pts with BCR::ABL1 >1% at baseline achieved BCR::ABL1 ≤1% by wk 48 and 96, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11286266	In addition, compared to parental cells, CRT∆ cells exhibited a smaller fraction of spliced XBP1 mRNA (XBP1s) (Figure 7A, right bar graph), consistent with the lower IRE1 activity measured by a XBP1s::mCherry reporter. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Standardized anti-lymphoma therapy is significantly associated with superior outcomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Standardized", "anti-lymphoma", "therapy", "is", "significantly", "associated", "with", "superior", "outcomes", ...
PMC9429973	S. Oztaskin, M. Yanasik, M. Ozbalak, M. Guzel Mastanzade, O. Ozluk, T. O. Tiryaki, S. Erdem, S. Besisik INTERNAL MEDICINE; BLOOD CENTER; INTERNAL MEDICINE HEMATOLOGY, ISTANBUL UNIVERSITY ISTANBUL MEDICAL FACULTY, ISTANBUL, Turkey Background: The red blood cell (RBC) alloimmunization rate varies with underlying disorder...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11774251	Figure 5Effects of Tan I on keratinocyte differentiation. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "5Effects", "of", "Tan", "I", "on", "keratinocyte", "differentiation", ".", "(" ] } ]
PMC11474209	Previous studies revealed MC-LR stress, suggesting that impairment of the peroxisome proliferator-activated receptor signaling pathway upregulated fatty acid biosynthesis and elongation to promote lipid accumulation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11320834	Data are shown as the % of proliferation decrease, combination index (CI), and dose reduction index (DRI) in A EOC 1, B EOC 2, C EOC 3, D EOC 4, E OCI-E1p, F Ascites.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11794847	This glycolytic switch is essential for generating metabolic intermediates necessary for biomass synthesis, supporting the rapid growth and proliferation of activated T cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC3888431	A total number of 28,874 transcripts located on 16,412 unique gene loci were predicted for this reference-based re-assembly.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "total", "number", "of", "28,874",...
PMC11672881	Gene ontology (GO) analysis is a widely used and effective approach for annotating genes and their products, as well as for identifying the biological features of high-throughput genome or transcriptome data .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11604015	The TET-OFF expression system is a system that can temporarily regulate the CAR gene and thereby adjust CAR-T cells in a reversible manner.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11201245	Signal patterns that deviate from the typical diploid structure of two signals per loci are considered conspicuous.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Signal", "patterns", "that", "deviate", "from", ...
PMC11697065	For HC and LC staining, cells were washed twice on ice with DPBS containing 1 % BSA, followed by a centrifugation step at 130 x g for 5 min to remove the washing solution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9503685	Elevated production of mucus in CF lungs facilitates invasion of the lung epithelium by opportunistic pathogens such as P. aeruginosa, including adhesion and biofilm formation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC4816271	We modified the vector and open reading frames as follows: Vector 3’LTR U3 was modified to include the chicken β-globin chromatin insulator .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", ...
PMC5811757	CRISPR/Cas9 gene editing system was used to downregulate ABCB1 gene expression and its consequences were evaluated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CRISPR/Cas9", "gene", "editing", "system", "was", "use...
PMC11216402	Similarly, FGF5 is flanked by an upstream distal peak (FGF5_E) (Fig. 6E), which is active in primary TCGA-STAD cancer and inactive in healthy stomach tissue.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11792090	However, the efficacy of UCAR-T therapy was not as good as expected, especially in solid tumors (15).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "t...
PMC8540692	Other research groups already showed that UHRF1 can be targeted by phytocompounds, including curcumin, but both downregulation and upregulation were reported, depending on the cell line analyzed and the time of exposure to the compound .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	BCMA and CS1 were highly expressed on MM cells in BM (median BCMA+ 77.2% and CS1 + 96.5%) and EMD (Figure 1B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8193046	The model was generated on the basis of (i) the identification of basic scaffolds amongst the most potent known ABCB1, ABCC1, and ABCG2 inhibitors; (ii) the definition of substructures with a positive impact regarding multitarget ABCB1, ABCC1, and ABCG2 inhibition; and (iii) the definition of substructures with a negat...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11615828	a,c) COS7 cells (a) and primary cultured cortical neurons (c) co‐expressing EMTB‐CFP‐FRB (blue) and mNeon‐FKBP‐VAMP2 were treated with rapamycin (Rapa, 100 nM) for inducible immobilization of synaptic vesicles.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11743975	The cells grown at 70%–90% confluency were transiently transfected with Lipofectamine 3000 (Thermo Fisher) according to the manufacturer′s instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells...
PMC11566417	One type of biologic is the cell secretome, which contains all bioactive factors secreted by the cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "type", "of", "biologic", "is", ...
PMC10758402	The study was conducted in accordance with the local legislation and institutional requirements.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "study", "was", "conducted", "in", "accordance", "with", "the", ...
PMC10907726	Western blot was used to detect the EGFR, ERK, p-ERK, PI3K, AKT, p-AKT, mTOR and p-mTOR expression. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Pts who achieved CR or CR with incomplete hematologic recovery (CRi) received up to 4 cycles of high-dose cytarabine plus Quiz (40 mg/day) or PBO and/or allo-HCT followed by up to 3 y of continuation therapy with Quiz (30-60 mg/day) or PBO.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11525028	For hematoxylin and eosin (H&E) staining, the tissues were fixed in formalin, embedded in paraffin, and sectioned at a thickness of 5μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10669128	This model has already been effectively applied in the field of genetic and oncological diseases, thanks to its capability to reproduce disease phenotypes within the appropriate cellular lineage .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The most common non-hematological grade 3-5 adverse events were febrile neutropenia (73%, 11/15), sepsis/bacteremia (53%, 8/15), pneumonia (33%, 5/15) and secondary hemophagocytosis (13%, 2/15).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11615828	After this incubation, the unbound RBD protein was washed out using a medium containing 4% FBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "this", "incubation", ",", "th...
PMC9516401	This is where a group of inhibitors called insulin-degrading enzyme (IDE) inhibitors come into action.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "where", "a", "group", "of", ...
PMC9429973	NGS analysis revealed 3/4 patients has the mutation of TP53, solely or with other cytogenetic disorders, and the other one has the mutation of ATM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11759543	Cytotoxicity of combined 1.5 μM doxorubicin and 5 μM vorinostat for 24, 48 and 72 h treatment in SV-HUC-1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O" ], "tokens": [ "Cytotoxicity", "of", ...
PMC11802855	The expression level of CXCL7 and the activation of “Osteolysis signaling”(I)/“B cell proliferation”(J) pathway in TT3 set).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expression", "level",...
PMC10213199	Finally, 25–100 μL of DEPC-treated water was added to dissolve the RNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "25–100", "μL", "of", "DEPC-treated", "water", "was", ...
PMC11594806	In the phase 2 study (NCT04668300), patients with recurrent or metastatic angiosarcoma (cohort 1), dedifferentiated liposarcoma (DLPS) (cohort 2), and recurrent or metastatic osteosarcoma (OS) (cohort 3) were eligible if they had received at least one prior systemic therapy but had not been treated with checkpoint inhi...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11758416	Note: Preparation of T cells (Part 2) should be done during L cell preparation (Part 1) to avoid cell death.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC8623816	The genetic organization of the two dsRNAs is shown in Figure 2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "genetic", "organization", "of", "the", "two", "dsRNAs", "is", "shown", ...
PMC11679033	Interestingly, CBD’s cytotoxicity was 1.5- to 4-fold higher than CIT in both HepG2 and SH-SY5Y, reinforcing the compound’s varied cellular interaction profile .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11144200	Therefore, based on its outstanding compatibility and toxicity identification, we postulated that LPS-Nb36 might be able for being immediately utilized within the creation of in vivo medicinal systems for drug delivery.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11591030	The LPS + AOP, LPS + PDTC, and LPS + PDTC + AOP treatments mitigated the excessive decrease in Nrf2 and its downstream target genes caused by LPS and reduced the overexpression of Keap1 (p < 0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9910796	Also, the labeling of two major nucleoid proteins, the DNA-binding proteins pK78R and pA104R, was significantly diminished, with the exception of the minor fraction of defective particles containing an aberrant nucleoid.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11666785	The width of Actin bundles are indicated by red arrows.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "width", "of", "Actin", "bundles", "are", "indicated", "by", "red", "arrows", "." ...
PMC6379402	Then, we run SAFE ten times (to account for the heuristic nature of its embedding step) on each of the real and randomized iCells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11471176	Collection of MCF-7 cells is facilitated by trypsin-EDTA which help in detaching and dissociating adherent cells, and their concentration is adjusted to achieve a count of 10,000 cells.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11607764	To the best of our knowledge, there is no study on pan-cancer analysis for PTBP1 in Literature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "the", "best", "of", "our", ...

PMC9454852

To prove its involvement in the generation of the [Ca]i peak after the BOLD-100 addition, the confocal time-lapse observation was repeated in the presence of 200 µM anisomycin (30 min pretreatment), that inhibits the ER Ca leak through TLC .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11786704

The results showed no significant lesions or damage in these organs 15 days after injection of PC capsules compared to the control group (Fig. 7E), further indicating that PC capsules possess great biocompatibility.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Daratumumab (DARA), a human IgGκ monoclonal antibody targeting CD38 approved for treating multiple myeloma, has shown preclinical efficacy in ALL models.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11732628

All the experiments were repeated three times.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "the", "experiments", "were", "repeated", "three", "times", "." ] } ]

PMC9429973

Notably, long-term safety and impact on patients’ QoL were reported by 38.6% and 34.3% of physicians, respectively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",...

PMC5854676

R.S. Kumaran investigated MgO nanoparticles (NP) with 20 nm size via the GST and ROS gene mechanism.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "R.S.", "Kumaran", "investigated", ...

PMC11694625

Reactive oxygen species (ROS) play the essential role in regulating immune responses, including anticancer, antibacterial and antiviral responses.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Reactive", "...

PMC9429973

Most frequently reported AEs were manageable cytopenia and folliculitis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Most", "frequently", "reported", "AEs", "were", "manageable", "cytopenia", "and", "folliculitis", "." ]...

PMC11139449

To identify any possible off-target sites, determine the number of mismatches, and evaluate the size of these mismatches, Cas-offinder software (http://www.rgenome.net/cas-offinder/) was used.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8992508

In this way R-verapamil, VX-710 (biricodar) and PSC-833 (valspodar were obtained.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "way", "R-verapamil", ",", "VX-710", "(", ...

PMC7570809

were grown in RPMI with added heat-inactivated 10% FBS (fetal bovine serum), 2 mM glutamine, 100 U/mL penicillin and 100 µg/mL streptomycin (Euroclone, Milan, Italy).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11116779

A standard curve with H2O2 concentrations in the 0–100 μM range was constructed.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "standard", "curve", "with", "H2O2", "concentrations", "in", "the", ...

PMC10698968

Notably, as other research groups noticed, we reported the presence of large, rare multinucleated cells .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",", "as", "other", "researc...

PMC9429973

NGS at MDS dx showed more frequent TP53 mutations in t-MDS than in de novo MDS (73% vs 36%, p=0.003).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC10988808

Additionally, the potential of CCDC25 as a prognostic marker warrants comprehensive validation in larger, multicentric cohorts.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "the", "potential", ...

PMC11499955

Most of the [F]6 uptake remained on the tumor even 4 hours post-injection.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Most", "of", "the", "[F]6", "uptake", "remained", "on", "the", "tumor...

PMC10808409

TPGS is commonly used in formulating drugs used for cancer therapy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TPGS", "is", "commonly", "used", "in", "formulating", "drugs", "used", "for", "cancer...

PMC10998613

β2AR exhibited a modest degree of cross-correlation in COS-7 and MDA-MB-231 cells (Fig. 3B).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "β2AR", "exhibited", "a", "modest", "degree...

PMC6771295

p < 0.05 was considered to be statistically significant.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.05", "was", "considered", "to", "be", "statistically", "significant", "." ] } ]

PMC9874064

Data were retrieved from TCGA datasets (http://gepia.cancer-pku.cn/).

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PMC10582049

These results indicate that ADH1B low samples are characterized by significantly more active inflammatory processes.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "indicate", "that", "ADH1B", "low", "sam...

PMC11397654

It was also demonstrated that 36 had low in vivo cytotoxicity, while the enhanced tumour suppression observed with 36-methotrexate was most likely due to synergy between the compounds, which was further proven by flow cytometric analysis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Although APL is considered a highly curable disease, early deaths (EDs, death within 30 days) due to coagulopathy and bleeding diathesis remain a significant challenge.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11185260

Cell cycle analysis of BT-12.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "cycle", "analysis", "of", "BT-12", "." ] } ]

PMC11670407

Different groups have reported that OTULIN deficiency can lead to severe autoinflammatory diseases called OTULIN-related autoinflammatory syndrome (ORAS, also termed otulipenia) .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC9429973

Aims: To determine the efficacy and safety of oral thalidomide combined with cyclophosphamide and dexamethasone (TCD) regimens in the treatment of recurrent/refractory LCH among adult patients.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9954564

For developing a model, 9/10th of the data is employed, and a classification error is estimated at the end.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "developing", ...

PMC11011837

Untargeted metabolomics analysis allowed the annotation of 126 polar metabolites: complete information is listed in Table S1.

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PMC11597291

PCT quantification was based on a calibration curve with R = 0.9976 and limit of quantification 0.01 μg/mL, with the linear part of the standard curve being from 0.01 to 100 μg/mL. The dispersion solution for PCT quantification was D-H2O:MeOH = 60:40 in %v/v.

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PMC11476837

Moreover, cells increased ROS in a similar manner when RA and ML-385 were used at a concentration of 5 μM in response to doxorubicin (p < 0.001).

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PMC11547917

Also, a calibration curve with Trolox concentrations ranging between 0.25 mg/mL and 31 µg/mL was made to calculate the concentrations of cell samples, based on the formula below:T-AOC = (A734-b) ÷ a ÷ No. of cells × f Y—Acontrol–ATrolox; x—concentration of standard; a—slope of standard curve; b—intercept of standard cu...

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PMC7369657

Samples were fixed in 10% formalin for histopathological analysis.

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PMC11768927

Overall, clinical trials employing VSV as a therapeutic agent substantiate its potential as an effective oncolytic virotherapy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overall", ",", "clinical", "trials", "...

PMC11748335

C A heatmap showing the top 20 significantly enriched GO terms for the genes associated with each group of peaks.

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PMC11489175

Inhibition of migration of ovarian cancer cells following knockdown is also observed upon interference with USP48, another USP that has been investigated in this disease 108.

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PMC11695623

The accuracy of the nomogram model was validated by comparing the predicted probabilities of the calibrated fold plots with the observed actual probabilities.

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PMC11469524

Since in our data instead of an attenuation we observe an upregulation of MEK phosphorylation in cells that show the p38 crosstalk when treated with p38 inhibitor (Figs 2F, 3A and 5A), we postulate that the crosstalk must act on or upstream of MEK.

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PMC3765139

Evidence of the capacity of CSCs to grow in spheroid structures has been repeatedly reported (refer to Introduction and Materials and Methods).

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PMC9429973

Recent studies have characterized the chromatin landscape of non-stereotyped CLLs and normal B cells (Beekman, et al. Nat Med.

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PMC11621493

PLA2G4D catalyzes the transfer of fatty acids between phospholipids. (

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PMC10919056

Genetic or acquired changes in connexin proteins are closely related to cancer (27).

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PMC11470999

Similarly, Transwell assays showed that rescue of CIP2A reversed the reduction in migration inhibition by PF in CIP2A knockdown cells (Figure S5E).

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PMC11543853

The dashed rectangle indicates the position of the area shown at higher magnification in panel B. Scale bar 200 nm.

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PMC10582049

Expression of ECM proteins in the samples with low (n = 105), intermediate (n = 209), and high (n = 105) expression of ADH1B (TCGA dataset).

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PMC3203927

The quantity of mRNA isolated from each sample was determined using absorption at 260 and 280 nm.

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PMC11731614

The average spectral counts for RD and HFD were used to obtain a HFD/RD fold change.

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PMC3122064

The role of p53 and MDM2 in cisplatin-induced apoptosis has been investigated using cisplatin-sensitive and -resistant human TC models.

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PMC11789597

Thus, genes involved in NK cell activation or inhibition in CAV1‐deficient MM cells were analyzed after RNA sequencing (Figure 2A; Figure S3A, Supporting Information).

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PMC10582049

A droplet-based scRNAseq method (10× Genomics) was used to perform a comprehensive analysis of the CAF population in the tumor microenvironment.

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PMC11397654

Moreover, calixarene was able to suppress the signal transduction of the Mer and AXL tyrosine kinase receptors, which are overexpressed in this type of cancer.

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PMC8345486

The doxorubicin HCl, gemcitabine HCl, and carboplatin were dissolved in H2O at 25 mM concentration.

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PMC10154881

not significant, Welch's t‐test.

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PMC11532793

Gibbs sampling slightly increased the total analysis time of edgeR as a side effect of including more transcripts in the statistical analyses.

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PMC9429973

Twenty (54.1%) and 23 (62.2%) of 37 pts with BCR::ABL1 >1% at baseline achieved BCR::ABL1 ≤1% by wk 48 and 96, respectively.

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PMC11286266

In addition, compared to parental cells, CRT∆ cells exhibited a smaller fraction of spliced XBP1 mRNA (XBP1s) (Figure 7A, right bar graph), consistent with the lower IRE1 activity measured by a XBP1s::mCherry reporter. (

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PMC9429973

Standardized anti-lymphoma therapy is significantly associated with superior outcomes.

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PMC9429973

S. Oztaskin, M. Yanasik, M. Ozbalak, M. Guzel Mastanzade, O. Ozluk, T. O. Tiryaki, S. Erdem, S. Besisik INTERNAL MEDICINE; BLOOD CENTER; INTERNAL MEDICINE HEMATOLOGY, ISTANBUL UNIVERSITY ISTANBUL MEDICAL FACULTY, ISTANBUL, Turkey Background: The red blood cell (RBC) alloimmunization rate varies with underlying disorder...

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PMC11774251

Figure 5Effects of Tan I on keratinocyte differentiation. (

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PMC11474209

Previous studies revealed MC-LR stress, suggesting that impairment of the peroxisome proliferator-activated receptor signaling pathway upregulated fatty acid biosynthesis and elongation to promote lipid accumulation .

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PMC11320834

Data are shown as the % of proliferation decrease, combination index (CI), and dose reduction index (DRI) in A EOC 1, B EOC 2, C EOC 3, D EOC 4, E OCI-E1p, F Ascites.

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PMC11794847

This glycolytic switch is essential for generating metabolic intermediates necessary for biomass synthesis, supporting the rapid growth and proliferation of activated T cells .

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PMC3888431

A total number of 28,874 transcripts located on 16,412 unique gene loci were predicted for this reference-based re-assembly.

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PMC11672881

Gene ontology (GO) analysis is a widely used and effective approach for annotating genes and their products, as well as for identifying the biological features of high-throughput genome or transcriptome data .

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PMC11604015

The TET-OFF expression system is a system that can temporarily regulate the CAR gene and thereby adjust CAR-T cells in a reversible manner.

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PMC11201245

Signal patterns that deviate from the typical diploid structure of two signals per loci are considered conspicuous.

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PMC11697065

For HC and LC staining, cells were washed twice on ice with DPBS containing 1 % BSA, followed by a centrifugation step at 130 x g for 5 min to remove the washing solution.

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PMC9503685

Elevated production of mucus in CF lungs facilitates invasion of the lung epithelium by opportunistic pathogens such as P. aeruginosa, including adhesion and biofilm formation.

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PMC4816271

We modified the vector and open reading frames as follows: Vector 3’LTR U3 was modified to include the chicken β-globin chromatin insulator .

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PMC5811757

CRISPR/Cas9 gene editing system was used to downregulate ABCB1 gene expression and its consequences were evaluated.

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PMC11216402

Similarly, FGF5 is flanked by an upstream distal peak (FGF5_E) (Fig. 6E), which is active in primary TCGA-STAD cancer and inactive in healthy stomach tissue.

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PMC11792090

However, the efficacy of UCAR-T therapy was not as good as expected, especially in solid tumors (15).

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PMC8540692

Other research groups already showed that UHRF1 can be targeted by phytocompounds, including curcumin, but both downregulation and upregulation were reported, depending on the cell line analyzed and the time of exposure to the compound .

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PMC9429973

BCMA and CS1 were highly expressed on MM cells in BM (median BCMA+ 77.2% and CS1 + 96.5%) and EMD (Figure 1B).

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PMC8193046

The model was generated on the basis of (i) the identification of basic scaffolds amongst the most potent known ABCB1, ABCC1, and ABCG2 inhibitors; (ii) the definition of substructures with a positive impact regarding multitarget ABCB1, ABCC1, and ABCG2 inhibition; and (iii) the definition of substructures with a negat...

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PMC11615828

a,c) COS7 cells (a) and primary cultured cortical neurons (c) co‐expressing EMTB‐CFP‐FRB (blue) and mNeon‐FKBP‐VAMP2 were treated with rapamycin (Rapa, 100 nM) for inducible immobilization of synaptic vesicles.

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PMC11743975

The cells grown at 70%–90% confluency were transiently transfected with Lipofectamine 3000 (Thermo Fisher) according to the manufacturer′s instructions.

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PMC11566417

One type of biologic is the cell secretome, which contains all bioactive factors secreted by the cells.

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PMC10758402

The study was conducted in accordance with the local legislation and institutional requirements.

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PMC10907726

Western blot was used to detect the EGFR, ERK, p-ERK, PI3K, AKT, p-AKT, mTOR and p-mTOR expression. (

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PMC9429973

Pts who achieved CR or CR with incomplete hematologic recovery (CRi) received up to 4 cycles of high-dose cytarabine plus Quiz (40 mg/day) or PBO and/or allo-HCT followed by up to 3 y of continuation therapy with Quiz (30-60 mg/day) or PBO.

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PMC11525028

For hematoxylin and eosin (H&E) staining, the tissues were fixed in formalin, embedded in paraffin, and sectioned at a thickness of 5μm.

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PMC10669128

This model has already been effectively applied in the field of genetic and oncological diseases, thanks to its capability to reproduce disease phenotypes within the appropriate cellular lineage .

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PMC9429973

The most common non-hematological grade 3-5 adverse events were febrile neutropenia (73%, 11/15), sepsis/bacteremia (53%, 8/15), pneumonia (33%, 5/15) and secondary hemophagocytosis (13%, 2/15).

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PMC11615828

After this incubation, the unbound RBD protein was washed out using a medium containing 4% FBS.

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PMC9516401

This is where a group of inhibitors called insulin-degrading enzyme (IDE) inhibitors come into action.

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PMC9429973

NGS analysis revealed 3/4 patients has the mutation of TP53, solely or with other cytogenetic disorders, and the other one has the mutation of ATM.

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PMC11759543

Cytotoxicity of combined 1.5 μM doxorubicin and 5 μM vorinostat for 24, 48 and 72 h treatment in SV-HUC-1.

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PMC11802855

The expression level of CXCL7 and the activation of “Osteolysis signaling”(I)/“B cell proliferation”(J) pathway in TT3 set).

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PMC10213199

Finally, 25–100 μL of DEPC-treated water was added to dissolve the RNA.

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PMC11594806

In the phase 2 study (NCT04668300), patients with recurrent or metastatic angiosarcoma (cohort 1), dedifferentiated liposarcoma (DLPS) (cohort 2), and recurrent or metastatic osteosarcoma (OS) (cohort 3) were eligible if they had received at least one prior systemic therapy but had not been treated with checkpoint inhi...

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PMC11758416

Note: Preparation of T cells (Part 2) should be done during L cell preparation (Part 1) to avoid cell death.

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PMC8623816

The genetic organization of the two dsRNAs is shown in Figure 2.

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PMC11679033

Interestingly, CBD’s cytotoxicity was 1.5- to 4-fold higher than CIT in both HepG2 and SH-SY5Y, reinforcing the compound’s varied cellular interaction profile .

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PMC11144200

Therefore, based on its outstanding compatibility and toxicity identification, we postulated that LPS-Nb36 might be able for being immediately utilized within the creation of in vivo medicinal systems for drug delivery.

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PMC11591030

The LPS + AOP, LPS + PDTC, and LPS + PDTC + AOP treatments mitigated the excessive decrease in Nrf2 and its downstream target genes caused by LPS and reduced the overexpression of Keap1 (p < 0.05).

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PMC9910796

Also, the labeling of two major nucleoid proteins, the DNA-binding proteins pK78R and pA104R, was significantly diminished, with the exception of the minor fraction of defective particles containing an aberrant nucleoid.

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PMC11666785

The width of Actin bundles are indicated by red arrows.

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PMC6379402

Then, we run SAFE ten times (to account for the heuristic nature of its embedding step) on each of the real and randomized iCells.

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PMC11471176

Collection of MCF-7 cells is facilitated by trypsin-EDTA which help in detaching and dissociating adherent cells, and their concentration is adjusted to achieve a count of 10,000 cells.

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PMC11607764

To the best of our knowledge, there is no study on pan-cancer analysis for PTBP1 in Literature.

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