OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11472639	In a series of other exploratory experiments, repeated measures ANOVA revealed no significant effects of time (pre-, post- and 30-min post-exercise) for whole blood ADCC (ADCCWB) (F(1.18,8.25) = 1.81, p = 0.22, ηp = 0.21) or whole blood AICC (AICCWB) (F(2,14) = 2.56, p = 0.11, ηp = 0.27) against RPMI-8226 cells (Supple...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8193813	The NO sensor (NO-D4) is an electrochemical gas sensor (Alphasense, Essex, UK) that measures concentration by changes in impedance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10079526	Ni-NTA beads (30210, Qiagen, Hilden, Germany) were added to the lysates and incubated overnight at 4 ˚C. Ni-NTA beads were washed extensively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11798926	Inspired by research into the endocytic trafficking of IFITM3 mediated by an interaction with the μ2 AP subunit (Jia et al., 2014; Chesarino et al., 2014), we performed co-immunoprecipitation experiments in HEK293T cells with several SynDIG proteins: SynDIG1 (also known as Tmem90b), the closely related SynDIG2 (also kn...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4360730	Assays have been annotated to OBI (e.g. RRBS—OBI:0001862 and MeDIP-seq—OBI:000693).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Assays", "have", "been", "annotated", "to", "OBI", ...
PMC10411253	All authors declare no competing interests.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "authors", "declare", "no", "competing", "interests", "." ] } ]
PMC9817179	Moreover, given that fixation can artificially generate intranuclear puncta of EGFP-EWS(IDR) that is homogenously distributed across the live-cell nucleus (Figure 1A), extra caution is required in interpreting immunofluorescence-detected intracellular puncta of an endogenously expressed protein as LLPS as the same punc...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10652261	As a result, targeting apoptosis, the most successful nonsurgical therapeutic strategy, is effective for all types of cancer since evasion of apoptosis is a crucial hallmark of cancer and is not specific to the etiology or type of cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806106	We transfected each construct into HEK293T cells (human embryonic kidney cells) and tested the plasma membrane localization as well as the agonist-induced FRET change in single-cell recordings at a microscope.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10114490	Single-cell cloned iHDF entered senescence and stop proliferating after eight additional population doublings (Fig. 1B), limiting our experimental setting and overall utility of the model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11342785	B, TIRF and EM images showing the in vitro bundling behavior of native TPPP-FL and the isolated TPPP-CORE domain.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", ",", "TIRF", "and"...
PMC11658074	APN binds to AdipoR, activating the AMPK pathway, which inhibits NF-κB and reduces iNOS expression, countering UVB-induced MAPK/NF-κB activation, which increases the expression of MMPs and decreases the expression of procollagen I and III .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6600253	Moreover, curcumin has also been shown to block the association of p23 and the hTERT complex then disrupted the assemble of telomerase, resulting in telomerase inactivation and cell death in cancer cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: Male predominance is seen in all three groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "Male", "predominance", "is", "seen", "in", "all", "three", "groups", "." ...
PMC11672142	An EPR spectrum was collected to determine the Fe(III) coordination modality (Figure 1C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "EPR", "spectrum", "was", "collected", "to", ...
PMC9429973	Efficacy and safety profiles of TKIs are similar in adult and pediatric pts; however, growth retardation has been reported in the pediatric population, in whom long-term adverse effects are unknown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6461034	Rinse the beads by adding an additional 30 μl 0.15% TFA at room temperature, and immediately retrieve 20–25 μl by careful pipetting, making sure not to take along any beads.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10203589	FGF18 is known to be inextricably related to β-catenin (10, 69, 70).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FGF18", "is", "known", "to", "be", "inextricably", ...
PMC9429973	-URD Cords (69 vs 37): an increase in activity in nearly all months, however few cases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "-URD", "Cords", "(", "69", ...
PMC10538569	Human CD4 T cells transduced with pRRL-GPI-scFv X5, but without iDCs-HIV-1 AD8 (upper-left panel).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Human", "CD4", "T", "cells", "transduced", ...
PMC6934009	In the present study, wogonin treatment reduced the proliferation of A549 and A427 carcinoma cells markedly in comparison to the control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "...
PMC11766309	The colony formation experiment was conducted by seeding cells in 6-well plates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "colony", "formation", "experiment", "was", "conducted", "by", "seeding", ...
PMC11767582	Likewise, triazoles monosubsituted at the para position of the phenyl B-ring with methyl (3d), triflouromethyl (3e), fluorine (3f), chlorine (3g), and bromine (3h) groups were either non-cytotoxic or weakly cytotoxic.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In the double-drug combination experiment, we used CCK-8 assays to detect the effect of drugs on the viability of the three cell lines, used CompuSyn software to calculate the combination index (CI), which indicates additive effects (CI = 1.0), synergism (CI < 1.0), and antagonism (CI > 1.0).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11371627	It hence remains of great interest to further analyse intracellular processes and identify differences in patients with physiologically intact XK protein and in patients with pathogenic XK gene changes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4695073	In this study, we found that downregulating XPA sensitized NPC cells to cisplatin, and high expression of XPA was associated with poor prognosis in NPC patients treated with platinum-based chemoradiotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11291490	a Schematic diagram of the vaccination and sampling procedure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "a", "Schematic", "diagram", "of", "the", "vaccination", "and", "sampling", "procedure", "." ] } ]
PMC11726183	The Q log P describes the solubility and QP log BB predicts the capability of blood–brain barrier permeation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Q", "log", "P",...
PMC10728200	First, we verified overexpression of STUB1 (Fig. 4B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "First", ",", "we", "verified", "overexpression", "of", "STUB1", "(", "Fig.", "4B", ...
PMC10419319	After the tumor challenge, Balb/c-nude mice were intraperitoneally injected with 20 mg/kg isoalantolactone every day and 2.5 mg/kg cisplatin every three days for 17 days.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11186948	Heatmap of RNA-seq expression data showing top 50 DEGs in two controls (HD1 and HD2, also referred as HD), patient #249 and RSTS patient (CREBBP) (both referred as MUT); DEGs were selected based on nominal p value less than 0.05 and actual foldchange higher than 1.5 or lower than 0.67. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11607321	Furthermore, MOSA consistently outperformed the other methods in tissue of origin clustering (Supplementary Fig. 6c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "MOSA", "consistently", ...
PMC11300085	We pointed out an undocumented mechanism involving the CMKLR1/RhoA/ROCK1-mediated EMT pathway that might be a prospective indicator for the therapies of high metastasis ovarian malignant cancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11753435	PepPrCLIP, leveraging only sequence embeddings, benefits from much faster generation and prioritization, generating ~1000 peptides per minute on a standard T4 TPU and requiring ~1 min to rank 100,000 peptides per protein target.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11377827	A Snakemake pipeline was used to analyse the data (10.5281/zenodo.10139567): after investigating the quality of the raw data using FastQC and MultiQC, sequence reads were trimmed to remove adaptor sequences and nucleotides with poor quality using TrimGalore.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8389560	SeNP is often used as carriers of chemotherapeutic agents such as cisplatin, 5-fluorouracil, doxorubicin, and irinotecan .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SeNP", "is", "often", "used", ...
PMC11549062	Compared to Rab5 RNAi treatment only, no obvious rescue nor enhancement of dynamic endocytosis was found in Rab5 shRNA RNAi cells upon overexpressing PDGFR‐β or further PTP1B inhibition (Figure 4A,B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11092382	These alterations cannot be attributed to inhibition of CYP3A4 and 2C9 activity, indicating a potential interaction between sophocarpine and umbralisib that warrants further investigation in future studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11004721	They also apologize to the readership for any inconvenience caused.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "also", "apologize", "to", "the", "readership", "for", "any", "inconvenience", "caused", ...
PMC11754784	The release of Nb-S from DNP2 was tested by real-time fluorescent kinetics measurement (Fig. 3e).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "release", "of", "Nb-S", "from", "DNP...
PMC3681794	Protein levels of HIF-1 and CA IX were determined in simultaneously plated cells by western blotting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Protein", "levels", "of", "HIF-1", "and", "CA", ...
PMC11700523	The primary antibodies used for the Western blots were anti-MR (PP-H2133-00, Perseus Proteomics Inc., Tokyo, Japan) or anti-GAPDH (Sigma-Aldrich) antibodies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8427838	The graph is a representative of filopodia formation in RKO cells expressing an empty vector (EV) or TMIGD1 (20 cells/group) **p < 0.01.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11476837	Cells were seeded onto 6-well plates at a density of 2 × 10 cells/mL per well.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "seeded", "onto", "6-well", "plates", ...
PMC11725127	The protein levels of KRAS and USP2 were examined by Western blot. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "protein", "levels", "of", "KRAS", "and", "USP2", "were", "exam...
PMC11604830	CSI images were acquired before administration and then at 4 and 24 h after the systemic injection of the nanosystem (Figure 6A–C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11536589	Images are the removed tumors in the mice that were killed on day 16.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Images", "are", "the", "removed", "tumors", "in", "the", "mice",...
PMC11765243	The functional impact of p110α inactivation in T lymphocytes was also studied by comparing cells from WT or p110αKD-T mice cultured in vitro under conditions favoring the differentiation of distinct T helper subsets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7887261	False discovery rate (FDR) adjusted P-value was reported.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "False", "discovery", "rate", "(", "FDR", ")", "adjusted", "P-value", "was", "reported", "....
PMC9429973	We confirmed that 14-3-3ζ was hyperacetylated after ACY-1215 exposure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "confirmed", "that", "14", "-", "3", "-", "3ζ", "was", "hy...
PMC11127909	Scale bar = 1 cm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", "=", "1", "cm", "." ] } ]
PMC11672142	The intracellular LIP consists of an equilibrium between Fe(II) and Fe(III) but Fe(II) species predominate because of the cellular reducing environment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10706275	Afterwards, we applied the same method to clone the HSA gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Afterwards", ",", "we", "applied", "the", "same", "method", "to", "clone", ...
PMC11576293	The epidermal growth factor receptor (EGFR) is a type of membrane receptor tyrosine kinase that is excessively expressed in various tumors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11291697	Based on these premises, we explored the transcriptomic profile of our proband to evaluate the functional consequences of the novel GTDC1 de novo intragenic deletion in relation to the observed neurodevelopmental phenotype.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11590005	It is important to note that white stu-dents predominated in the dental schools observed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "important", "to", "note", "that", "white", "stu-dent...
PMC11518702	In a M17/Hgal knockout mouse model, B- or T-cell populations were not altered (although numbers of Peyer’s patches were lessened) (41).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: In this study, we aimed to derive and validate of a simple rule using complete blood count and white blood cell differential (CBC) parameters to predict the likelihood of having a JAK2 mutation in patients referred for elevated hemoglobin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: The most adhesive physiological “BMME mix” was identified as HS5, HUVEC and hFOB 1.19 in equal 1/3 proportions (p=0.0001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O"...
PMC9351137	A The midbody can be subdivided in three main regions : the midbody ring (red), containing anillin and citron kinase and other contractile ring components; the midbody central core (blue) marked by central spindle proteins such as the centralspindlin complex; and the midbody arms (green) where Aurora B and the other co...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8567602	These included axon guidance, β-catenin, and Frizzled pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "included", "axon", "guidance", ",", "β-catenin", ",", "and", "Frizzled", "pathways", ...
PMC8481254	The liver cancer cell lines Bel-7404, HL-7702, Bel-7402, SMMC-7721, SK-Hep1, and HEK-293T were obtained from our previous study .	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", ...
PMC11711345	Our results also indicated the absence of antiproliferation by p-cymene at 100 µM, corroborating most of the data in the literature for eight other HCCLs (Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6892818	Despite basal levels of IL-8, mCD40L rapidly augmented IL-8 secretion in all RCC lines (3–6 h) (Fig. 4a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Despite...
PMC11587606	Data are mean ± SD, P<0.01, P<0.05, data are analyzed by Student-t test It has been reported previously that the nuclear transporter receptor importin β1 is pivotal in nuclear translocation of aPKC, and that the action depends on aPKC tyrosine phosphorylation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11395280	Reagents CCL19 and CCL21 were purchased from R&D labs, and muCCL198-83 was purchased from Pepmic, Suzhou, China.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Reagents", "...
PMC11596967	These studies are aimed at systematically evaluating their protective effects against radiation-induced cellular damage, thereby potentially introducing novel therapeutic strategies for managing oxidative stress.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11733919	When 30 nmol/0.1 mg of Fe (17-AAG) or 20 nmol/0.1 mg of Fe (17-DMAG) was used, the MNPs remained stable over time.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9031474	Indeed, Dasari et al. observed a high reactivity of the dialdehyde compounds with primary amines forming unstable pyrrole adducts .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Indeed", ",", "Dasari", ...
PMC11412721	Relative expression of p53 isoforms with an α or AS C-terminus in tissues of wild-type mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Relative", "expression", "of", "p53", "isoforms", "wit...
PMC8584666	As a negative control, # 22ΔGPI-80 cells were stained using the same method, but no vesicles were observed (Figure 1c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11740508	Cells incorporating the plasmid were selected by culture with 1 µg/mL puromycin dihydrochloride (Cat. #	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "incorporating", "the", "plasmid", "were", "se...
PMC11687167	In 2014, Walley et al. first proposed that PCSK9 is a critical regulator of the innate nervous system and mediates the whole immune response to infectious shock.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11323699	Interestingly, TAX2 has demonstrated the ability to reprogram highly vascularized tumors into poorly angiogenic ones across various cancer contexts [28, 30–32].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC8735881	The inhibitory activity of GPI-anchored inhibitors on cell–cell fusion was also determined in transduced CEMss-CCR5 cells as described previously .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "The", "inhibit...
PMC11462673	confirmed the conservative and essential role of the Ldb1-Lhx1-Ssbp transcription complex in pre-renal development .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "confirmed", "the", "conservative", "and", "essential", "role", "of", ...
PMC10123657	Cells can exchange proteins through structures such as gap junctions, extracellular vesicles, or tunneling nanotubes .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "can", "exchange", "proteins", "through",...
PMC8996378	Of all mechanisms, increased drug-efflux of structurally different anticancer drugs, mediated by ABC-transporter proteins is a common one (Borst and Elferink, 2002).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10936243	In the questionnaire, 57.1% (n = 28/49) claimed that they did not plan to add anything for cat patients because 48% of respondents (n = 13/27) said they had already provided all the basic resources (e.g. comfort, food, water, a hiding place, and toileting) in the cat cage (Figure 3).Figure 3.Respondents’ (n = 27 respon...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7053076	Recently, many transcription factor-binding sequences, such as those for p53, AP-1 and, very often, for NF-κB have been identified in the promoter region of the ABCB1 gene [21–23].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11604015	For instance, Mamonkin et al. designed a regulated expression system that reversibly inhibited CAR expression through doxycycline exposure in vitro and restored the CAR expression and antitumor function of transduced T cells in vivo by removing doxycycline before infusion .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9412887	On the other hand, after uptake by bulk tumor cells with hypoxia and high ROS, ATRA/CPT-NPS could simultaneously release ATRA and CPT, resulting powerful synergistic anticancer effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11365427	Briefly, after 48 h of phenylalanine deprivation, MM cells (5 × 10 cells/mL) were harvested and resuspended in a binding buffer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11697065	Pearson correlation coefficient was used to test significance in correlation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pearson", "correlation", "coefficient", "was", "used", "to", "test", "significance", "in", "corr...
PMC11389534	Similarly, UFM1, along with DDRGK1, has been found to interact with IκBα, resulting in the activation of NF‐κB transcriptional activity. ,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC5811757	To enhance the outcome of drug sensitivity, it is suggested that multiple sgRNAs be designed and experimentally evaluated for simultaneous targeting of multiple important transporters.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9119314	Cryptolepine (1) and 3–6 were also active against the emerging species P. knowlesi.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cryptolepine", "(", "1", ")", "and", "3–6", "were", "...
PMC11772449	The tumor volume was measured using an electronic caliper, and the calculation formula was as follows: volume (cm) = L × W × 0.5, where L and W represent length and width.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: This is a cohort analysis on RRMM pts managed between January 2018 and July 2021 at 10 Italian hematology centers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":...
PMC11365427	Histopathology of tumor tissues, including HE staining, cleaved caspase-3, and Ki67 immunohistochemistry for both the control and phenylalanine-deprivation groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Histopathology", ...
PMC11609529	293FT cells were seeded at 10 cells/well in a 24-well plate and incubated overnight.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "293FT", "cells", "were", "seeded", "at", "10", "cells/well", ...
PMC6364197	The cells pellet was resuspended in PBS and incubated with antibodies for 15 min at 37°C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "pellet", "was", "resus...
PMC11806818	In recent years, the incorporation of nanozymes into biosensors has opened new avenues for the detection of tumor biomarkers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "recent", "years", ...
PMC11748363	Interestingly, the effect of linker elongation was most visible in R = H, 4‐Cl and 3‐CF3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "the", "effect", ...
PMC10854447	Calc. (%)	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Calc", ".", "(", "%", ")" ] } ]
PMC9429973	For evaluating CAR-T cells expansion, pts’ cells were tested with a specific biotinilated CD19 CAR reagent followed by incubation with an anti-biotin PE conjugated MoAb.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11705547	CTLA-4 inhibitors enhance the anti-tumor effects of IL-36 by inhibiting Tregs, resulting in increased proliferation of CD8+ T cells and IFN-γ production, which act synergistically with cisplatin .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11607321	We then perform a multi-omic model explanation by calculating SHAP values for all omic input features to assess their importance for the latent space integration and the reconstruction of omic features (see Methods).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8193046	Amongst these molecules are the compounds revealed by C@PA, 8–9 and 11.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Amongst", "these", "molecules", "are", "the", "compounds", "revealed", "by"...
PMC9429973	Data were collected at 0 and 3 months.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "were", "collected", "at", "0", "and", "3", "months", "." ] } ]

PMC11472639

In a series of other exploratory experiments, repeated measures ANOVA revealed no significant effects of time (pre-, post- and 30-min post-exercise) for whole blood ADCC (ADCCWB) (F(1.18,8.25) = 1.81, p = 0.22, ηp = 0.21) or whole blood AICC (AICCWB) (F(2,14) = 2.56, p = 0.11, ηp = 0.27) against RPMI-8226 cells (Supple...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8193813

The NO sensor (NO-D4) is an electrochemical gas sensor (Alphasense, Essex, UK) that measures concentration by changes in impedance.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC10079526

Ni-NTA beads (30210, Qiagen, Hilden, Germany) were added to the lysates and incubated overnight at 4 ˚C. Ni-NTA beads were washed extensively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11798926

Inspired by research into the endocytic trafficking of IFITM3 mediated by an interaction with the μ2 AP subunit (Jia et al., 2014; Chesarino et al., 2014), we performed co-immunoprecipitation experiments in HEK293T cells with several SynDIG proteins: SynDIG1 (also known as Tmem90b), the closely related SynDIG2 (also kn...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC4360730

Assays have been annotated to OBI (e.g. RRBS—OBI:0001862 and MeDIP-seq—OBI:000693).

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PMC10411253

All authors declare no competing interests.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "authors", "declare", "no", "competing", "interests", "." ] } ]

PMC9817179

Moreover, given that fixation can artificially generate intranuclear puncta of EGFP-EWS(IDR) that is homogenously distributed across the live-cell nucleus (Figure 1A), extra caution is required in interpreting immunofluorescence-detected intracellular puncta of an endogenously expressed protein as LLPS as the same punc...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10652261

As a result, targeting apoptosis, the most successful nonsurgical therapeutic strategy, is effective for all types of cancer since evasion of apoptosis is a crucial hallmark of cancer and is not specific to the etiology or type of cancer.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11806106

We transfected each construct into HEK293T cells (human embryonic kidney cells) and tested the plasma membrane localization as well as the agonist-induced FRET change in single-cell recordings at a microscope.

[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10114490

Single-cell cloned iHDF entered senescence and stop proliferating after eight additional population doublings (Fig. 1B), limiting our experimental setting and overall utility of the model.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11342785

B, TIRF and EM images showing the in vitro bundling behavior of native TPPP-FL and the isolated TPPP-CORE domain.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", ",", "TIRF", "and"...

PMC11658074

APN binds to AdipoR, activating the AMPK pathway, which inhibits NF-κB and reduces iNOS expression, countering UVB-induced MAPK/NF-κB activation, which increases the expression of MMPs and decreases the expression of procollagen I and III .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6600253

Moreover, curcumin has also been shown to block the association of p23 and the hTERT complex then disrupted the assemble of telomerase, resulting in telomerase inactivation and cell death in cancer cells .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Results: Male predominance is seen in all three groups.

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PMC11672142

An EPR spectrum was collected to determine the Fe(III) coordination modality (Figure 1C).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "EPR", "spectrum", "was", "collected", "to", ...

PMC9429973

Efficacy and safety profiles of TKIs are similar in adult and pediatric pts; however, growth retardation has been reported in the pediatric population, in whom long-term adverse effects are unknown.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6461034

Rinse the beads by adding an additional 30 μl 0.15% TFA at room temperature, and immediately retrieve 20–25 μl by careful pipetting, making sure not to take along any beads.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10203589

FGF18 is known to be inextricably related to β-catenin (10, 69, 70).

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PMC9429973

-URD Cords (69 vs 37): an increase in activity in nearly all months, however few cases.

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PMC10538569

Human CD4 T cells transduced with pRRL-GPI-scFv X5, but without iDCs-HIV-1 AD8 (upper-left panel).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Human", "CD4", "T", "cells", "transduced", ...

PMC6934009

In the present study, wogonin treatment reduced the proliferation of A549 and A427 carcinoma cells markedly in comparison to the control.

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PMC11766309

The colony formation experiment was conducted by seeding cells in 6-well plates.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "colony", "formation", "experiment", "was", "conducted", "by", "seeding", ...

PMC11767582

Likewise, triazoles monosubsituted at the para position of the phenyl B-ring with methyl (3d), triflouromethyl (3e), fluorine (3f), chlorine (3g), and bromine (3h) groups were either non-cytotoxic or weakly cytotoxic.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

In the double-drug combination experiment, we used CCK-8 assays to detect the effect of drugs on the viability of the three cell lines, used CompuSyn software to calculate the combination index (CI), which indicates additive effects (CI = 1.0), synergism (CI < 1.0), and antagonism (CI > 1.0).

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PMC11371627

It hence remains of great interest to further analyse intracellular processes and identify differences in patients with physiologically intact XK protein and in patients with pathogenic XK gene changes.

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PMC4695073

In this study, we found that downregulating XPA sensitized NPC cells to cisplatin, and high expression of XPA was associated with poor prognosis in NPC patients treated with platinum-based chemoradiotherapy.

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PMC11291490

a Schematic diagram of the vaccination and sampling procedure.

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PMC11726183

The Q log P describes the solubility and QP log BB predicts the capability of blood–brain barrier permeation.

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PMC10728200

First, we verified overexpression of STUB1 (Fig. 4B).

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PMC10419319

After the tumor challenge, Balb/c-nude mice were intraperitoneally injected with 20 mg/kg isoalantolactone every day and 2.5 mg/kg cisplatin every three days for 17 days.

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PMC11186948

Heatmap of RNA-seq expression data showing top 50 DEGs in two controls (HD1 and HD2, also referred as HD), patient #249 and RSTS patient (CREBBP) (both referred as MUT); DEGs were selected based on nominal p value less than 0.05 and actual foldchange higher than 1.5 or lower than 0.67. (

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PMC11607321

Furthermore, MOSA consistently outperformed the other methods in tissue of origin clustering (Supplementary Fig. 6c).

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PMC11300085

We pointed out an undocumented mechanism involving the CMKLR1/RhoA/ROCK1-mediated EMT pathway that might be a prospective indicator for the therapies of high metastasis ovarian malignant cancers.

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PMC11753435

PepPrCLIP, leveraging only sequence embeddings, benefits from much faster generation and prioritization, generating ~1000 peptides per minute on a standard T4 TPU and requiring ~1 min to rank 100,000 peptides per protein target.

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PMC11377827

A Snakemake pipeline was used to analyse the data (10.5281/zenodo.10139567): after investigating the quality of the raw data using FastQC and MultiQC, sequence reads were trimmed to remove adaptor sequences and nucleotides with poor quality using TrimGalore.

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PMC8389560

SeNP is often used as carriers of chemotherapeutic agents such as cisplatin, 5-fluorouracil, doxorubicin, and irinotecan .

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PMC11549062

Compared to Rab5 RNAi treatment only, no obvious rescue nor enhancement of dynamic endocytosis was found in Rab5 shRNA RNAi cells upon overexpressing PDGFR‐β or further PTP1B inhibition (Figure 4A,B).

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PMC11092382

These alterations cannot be attributed to inhibition of CYP3A4 and 2C9 activity, indicating a potential interaction between sophocarpine and umbralisib that warrants further investigation in future studies.

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PMC11004721

They also apologize to the readership for any inconvenience caused.

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PMC11754784

The release of Nb-S from DNP2 was tested by real-time fluorescent kinetics measurement (Fig. 3e).

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PMC3681794

Protein levels of HIF-1 and CA IX were determined in simultaneously plated cells by western blotting.

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PMC11700523

The primary antibodies used for the Western blots were anti-MR (PP-H2133-00, Perseus Proteomics Inc., Tokyo, Japan) or anti-GAPDH (Sigma-Aldrich) antibodies.

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PMC8427838

The graph is a representative of filopodia formation in RKO cells expressing an empty vector (EV) or TMIGD1 (20 cells/group) **p < 0.01.

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PMC11476837

Cells were seeded onto 6-well plates at a density of 2 × 10 cells/mL per well.

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PMC11725127

The protein levels of KRAS and USP2 were examined by Western blot. (

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PMC11604830

CSI images were acquired before administration and then at 4 and 24 h after the systemic injection of the nanosystem (Figure 6A–C).

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PMC11536589

Images are the removed tumors in the mice that were killed on day 16.

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PMC11765243

The functional impact of p110α inactivation in T lymphocytes was also studied by comparing cells from WT or p110αKD-T mice cultured in vitro under conditions favoring the differentiation of distinct T helper subsets.

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PMC7887261

False discovery rate (FDR) adjusted P-value was reported.

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PMC9429973

We confirmed that 14-3-3ζ was hyperacetylated after ACY-1215 exposure.

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PMC11127909

Scale bar = 1 cm.

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PMC11672142

The intracellular LIP consists of an equilibrium between Fe(II) and Fe(III) but Fe(II) species predominate because of the cellular reducing environment.

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PMC10706275

Afterwards, we applied the same method to clone the HSA gene.

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PMC11576293

The epidermal growth factor receptor (EGFR) is a type of membrane receptor tyrosine kinase that is excessively expressed in various tumors.

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PMC11291697

Based on these premises, we explored the transcriptomic profile of our proband to evaluate the functional consequences of the novel GTDC1 de novo intragenic deletion in relation to the observed neurodevelopmental phenotype.

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PMC11590005

It is important to note that white stu-dents predominated in the dental schools observed.

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PMC11518702

In a M17/Hgal knockout mouse model, B- or T-cell populations were not altered (although numbers of Peyer’s patches were lessened) (41).

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PMC9429973

Aims: In this study, we aimed to derive and validate of a simple rule using complete blood count and white blood cell differential (CBC) parameters to predict the likelihood of having a JAK2 mutation in patients referred for elevated hemoglobin.

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PMC9429973

Results: The most adhesive physiological “BMME mix” was identified as HS5, HUVEC and hFOB 1.19 in equal 1/3 proportions (p=0.0001).

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PMC9351137

A The midbody can be subdivided in three main regions : the midbody ring (red), containing anillin and citron kinase and other contractile ring components; the midbody central core (blue) marked by central spindle proteins such as the centralspindlin complex; and the midbody arms (green) where Aurora B and the other co...

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PMC8567602

These included axon guidance, β-catenin, and Frizzled pathways.

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PMC8481254

The liver cancer cell lines Bel-7404, HL-7702, Bel-7402, SMMC-7721, SK-Hep1, and HEK-293T were obtained from our previous study .

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PMC11711345

Our results also indicated the absence of antiproliferation by p-cymene at 100 µM, corroborating most of the data in the literature for eight other HCCLs (Table 1).

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PMC6892818

Despite basal levels of IL-8, mCD40L rapidly augmented IL-8 secretion in all RCC lines (3–6 h) (Fig. 4a).

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PMC11587606

Data are mean ± SD, P<0.01, P<0.05, data are analyzed by Student-t test It has been reported previously that the nuclear transporter receptor importin β1 is pivotal in nuclear translocation of aPKC, and that the action depends on aPKC tyrosine phosphorylation .

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PMC11395280

Reagents CCL19 and CCL21 were purchased from R&D labs, and muCCL198-83 was purchased from Pepmic, Suzhou, China.

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PMC11596967

These studies are aimed at systematically evaluating their protective effects against radiation-induced cellular damage, thereby potentially introducing novel therapeutic strategies for managing oxidative stress.

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PMC11733919

When 30 nmol/0.1 mg of Fe (17-AAG) or 20 nmol/0.1 mg of Fe (17-DMAG) was used, the MNPs remained stable over time.

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PMC9031474

Indeed, Dasari et al. observed a high reactivity of the dialdehyde compounds with primary amines forming unstable pyrrole adducts .

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PMC11412721

Relative expression of p53 isoforms with an α or AS C-terminus in tissues of wild-type mice.

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PMC8584666

As a negative control, # 22ΔGPI-80 cells were stained using the same method, but no vesicles were observed (Figure 1c).

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PMC11740508

Cells incorporating the plasmid were selected by culture with 1 µg/mL puromycin dihydrochloride (Cat. #

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PMC11687167

In 2014, Walley et al. first proposed that PCSK9 is a critical regulator of the innate nervous system and mediates the whole immune response to infectious shock.

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PMC11323699

Interestingly, TAX2 has demonstrated the ability to reprogram highly vascularized tumors into poorly angiogenic ones across various cancer contexts [28, 30–32].

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PMC8735881

The inhibitory activity of GPI-anchored inhibitors on cell–cell fusion was also determined in transduced CEMss-CCR5 cells as described previously .

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PMC11462673

confirmed the conservative and essential role of the Ldb1-Lhx1-Ssbp transcription complex in pre-renal development .

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PMC10123657

Cells can exchange proteins through structures such as gap junctions, extracellular vesicles, or tunneling nanotubes .

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PMC8996378

Of all mechanisms, increased drug-efflux of structurally different anticancer drugs, mediated by ABC-transporter proteins is a common one (Borst and Elferink, 2002).

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PMC10936243

In the questionnaire, 57.1% (n = 28/49) claimed that they did not plan to add anything for cat patients because 48% of respondents (n = 13/27) said they had already provided all the basic resources (e.g. comfort, food, water, a hiding place, and toileting) in the cat cage (Figure 3).Figure 3.Respondents’ (n = 27 respon...

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PMC7053076

Recently, many transcription factor-binding sequences, such as those for p53, AP-1 and, very often, for NF-κB have been identified in the promoter region of the ABCB1 gene [21–23].

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PMC11604015

For instance, Mamonkin et al. designed a regulated expression system that reversibly inhibited CAR expression through doxycycline exposure in vitro and restored the CAR expression and antitumor function of transduced T cells in vivo by removing doxycycline before infusion .

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PMC9412887

On the other hand, after uptake by bulk tumor cells with hypoxia and high ROS, ATRA/CPT-NPS could simultaneously release ATRA and CPT, resulting powerful synergistic anticancer effects.

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PMC11365427

Briefly, after 48 h of phenylalanine deprivation, MM cells (5 × 10 cells/mL) were harvested and resuspended in a binding buffer.

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PMC11697065

Pearson correlation coefficient was used to test significance in correlation.

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PMC11389534

Similarly, UFM1, along with DDRGK1, has been found to interact with IκBα, resulting in the activation of NF‐κB transcriptional activity. ,

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PMC5811757

To enhance the outcome of drug sensitivity, it is suggested that multiple sgRNAs be designed and experimentally evaluated for simultaneous targeting of multiple important transporters.

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PMC9119314

Cryptolepine (1) and 3–6 were also active against the emerging species P. knowlesi.

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PMC11772449

The tumor volume was measured using an electronic caliper, and the calculation formula was as follows: volume (cm) = L × W × 0.5, where L and W represent length and width.

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PMC9429973

Methods: This is a cohort analysis on RRMM pts managed between January 2018 and July 2021 at 10 Italian hematology centers.

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PMC11365427

Histopathology of tumor tissues, including HE staining, cleaved caspase-3, and Ki67 immunohistochemistry for both the control and phenylalanine-deprivation groups.

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PMC11609529

293FT cells were seeded at 10 cells/well in a 24-well plate and incubated overnight.

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PMC6364197

The cells pellet was resuspended in PBS and incubated with antibodies for 15 min at 37°C.

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PMC11806818

In recent years, the incorporation of nanozymes into biosensors has opened new avenues for the detection of tumor biomarkers.

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PMC11748363

Interestingly, the effect of linker elongation was most visible in R = H, 4‐Cl and 3‐CF3.

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PMC10854447

Calc. (%)

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PMC9429973

For evaluating CAR-T cells expansion, pts’ cells were tested with a specific biotinilated CD19 CAR reagent followed by incubation with an anti-biotin PE conjugated MoAb.

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PMC11705547

CTLA-4 inhibitors enhance the anti-tumor effects of IL-36 by inhibiting Tregs, resulting in increased proliferation of CD8+ T cells and IFN-γ production, which act synergistically with cisplatin .

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PMC11607321

We then perform a multi-omic model explanation by calculating SHAP values for all omic input features to assess their importance for the latent space integration and the reconstruction of omic features (see Methods).

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PMC8193046

Amongst these molecules are the compounds revealed by C@PA, 8–9 and 11.

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PMC9429973

Data were collected at 0 and 3 months.

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