OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC10994876	Beads are placed in specially designed reaction tubes which is used as vessel for incubation, washing, and signal processing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Beads", "are", "p...
PMC9952933	However, a comparison of malignant bone cells and primary non-malignant bone cells with regard to possible selective in vitro effects of CAP remains elusive.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11401358	Amyloid protein was reported to change from a β-sheet structure to a random coil structure after oxidation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Amyloid", "protein", "was", "reported", "to", ...
PMC7305184	4 months, to see if we can induce development of adaptive resistance in cells to PEF treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "4", "months", ",", "to", "see", ...
PMC10547921	Then, the suitable sites on cryptophycin were analyzed: In unit A, para-substituted phenyls are more potent than ortho-substituted or meta-substituted analogs, and the para-substituted phenyl could be used as the conjugate point; Unit B is sensitive to slight modifications, such as 5-fluoro substitution on benzene ring...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11599565	We found a significant amplification of KRT80-ChgA dual-positive cells, indicating that these rare cells in non-tumoral ovarian tissues could be the progenitors that expand to form the tumor mass (Fig. 7, Panel C, upper block of IHC pictures, OR E–H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7642379	Indeed, the adherent progeny cell lines 293E and 293T are easier to detach by trypsinization compared to the parental HEK293, potentially through altered expression of cell adhesion, cytoskeletal and cell membrane proteins in accordance with the observed consensus changes between progeny cell lines and the parental HEK...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", ...
PMC11295144	The cells were blocked in 1% BSA in PBS for 30 min at room temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", "blocked", "in", "1", "%"...
PMC11025866	The same result was previously observed for VPA .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "same", "result", "was", "previously", "observed", "for", "VPA", "." ] } ]
PMC9429973	Survival curves were compared with Log-rank test, Cox proportional hazards test was used for multivariate analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Survival", "curves", "were", "compared", "with", ...
PMC7602170	Class IB PI3Ks include the catalytic subunit p110γ and regulatory subunit isoforms (p84/p87 or p101) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Class", "IB", "PI3Ks", "include", "the", "c...
PMC7762347	Moreover, CYN and the combination with MCLR upregulated CYP1A1 and target genes involved in DNA-damage response (CDKN1A, GADD45A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", "...
PMC10092581	The same complex, when dissolved in 20 : 80 NaCl‐D2O(100 mM)/DMSO‐d6, showed a ratio of 67 : 33 in favor of the α‐Cl which remained stable even after 9 days (Figure S14).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11519567	However, these small molecules lack specificity for the SS18-SSX.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "these", "small", "molecules", "lack", "specificity", "for", "the", "SS18-SSX", ...
PMC11352746	Both approaches may result in a single time point since the cells are usually not viable after exposure to stains and dyes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "appr...
PMC5854676	In addition, the immunofluorescence test was performed following assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "the", "immunofluorescence", "test", "was", "performed", "following", "ass...
PMC11473843	Relative quantification of cell death by flow cytometry analysis of Annexin V-Atto 633 (AV) -positive + Annexin V/PI (AV/PI)-positive + PI-positive gated populations in HBEC3-FAK KO cells previously transduced as in (D); n = 4. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellL...
PMC11743414	P < 0.05;P < 0.01;*P < 0.001, the difference was statistically significant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "<", "0.05;P", "<", "0.01;*P", "<", "0.001", ",", "the", ...
PMC11409031	In this study, we identified T cell subsets as characteristic cell subsets of OV by analyzing OV single-cell data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "study", ...
PMC11541409	After molecular genetic testing on tumor biopsy, careful selection and combination of approved TKIs with appropriate dosing schemes could help effectively target multiple secondary mutations in KIT/PDGFRA .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10198699	This issue is sure to be canvassed in the lawsuit filed at the end of 2021 by the estate of Henrietta Lacks against Thermo Fisher Scientific; it is likely that all profits made by the biotech company from commercializing the HeLa cell line will be claimed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11543935	PRFS-Thermometry relies on the resonance frequency of hydrogen atoms being approximately linearly dependent on temperature in molecules with hydrogen bond-bound hydrogen at temperatures around room temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	This is a retrospective study conducted at American University of Beirut Medical Center (AUBMC).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "a", "retrospective", "study", "conducted...
PMC9429973	Median PFS did not differ by type of salvage treatment used (p-value= 0.7).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "PFS", "did", "not", "differ", "by", "type", ...
PMC9583612	Yet, such inventories are often a major component of any operator or government’s climate action plans.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Yet", ",", "such", "inventories", "are...
PMC11407042	Determine cell number 3 times using the Count Star automated cell counter.i.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Determine", "cell", "number", "3", "times", "using", "the", "Count", "Star", ...
PMC11257988	Hillig et al. designed a pan-KRAS inhibitor, BAY-293, using a dual-screening approach and structure-guided design.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hillig", "et", "al.", "designed", "a", "pan...
PMC11012012	Coma et al. (2017) observed a downregulated expression of SLAMF2/CD48 in pathological CLL B cells when compared to normal B cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Coma", ...
PMC11194678	G and H) Left: Representative immunostaining images showing co-localization and enrichment (white arrows) of endogenous PABPC1 (red) (G) or RPL7a (red) (H) within STAU1 condensate (green) in HepG2 and COS7 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8041314	In case one compound was evaluated with a definite number (e.g., 9.6 μM) and an estimation (e.g., >25 μM), the definite number was always given priority, while the estimated value was not considered.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3164356	Neu5Gc is immunogenic in humans.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Neu5Gc", "is", "immunogenic", "in", "humans", "." ] } ]
PMC11781181	With the deepening of research into the ferroptotic mechanism, many specific ferroptosis inhibitors have been identified.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", "the", "deepening", "of", "research", ...
PMC10048572	Therefore, we expected to see the emergence of new aberrant clones and changes in the mutational landscape during cell culture propagation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ...
PMC11701801	KREMEN2 is a single-pass transmembrane protein that plays a role in suppressing the apoptosis pathway via interaction with KREMEN1 (19, 33, 34); therefore, we examined the expression of KREMEN2 mRNA in SMARCA4/SMARCA2-deficient and SS18–SSX fusion cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11739696	The protein-bound SRB was then dissolved, and absorbance was measured at 540 nm using a BMG LABTECH-FLUO Star Omega microplate reader (Ortenberg, Germany).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11462673	The cell precipitate obtained after centrifugation was collected and was resuspended using a 100 μl wash buffer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cell", "precipitate", "obtained", "after",...
PMC11545868	Under certain conditions of cellular stress, the mitochondrial outer membrane permeability (MOMP) increases, releasing cytochrome c, which interacts with an apoptosis-inducing factor called APAF1 (apoptotic peptidase activator 1) to form an apoptosome, leading to caspase-mediated cell death .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9621239	Sn at each amino acid site in genotype-B clones. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sn", "at", "each", "amino", "acid", "site", "in", "genotype-B", "clones", ".", "(" ] ...
PMC11470381	Subsequent deeper examination enabled us to identify a similar mechanism operating during chemokine-driven, ICAM-1-dependent human CD4 T-lymphocyte migration .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequent", "deeper", "examination", ...
PMC9646302	The 786-0 cell line with LAPTM5 overexpression was injected into mice, and the time until tumor visualization was observed.	[ { "tags": [ "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": ...
PMC10545062	Instead of considering the hemodynamic response to a fluid bolus as simply a binary outcome, we expanded into three state conditions after fluid test bolus based on MAP response: nonresponsive (MAP increase <3 mm Hg), partially responsive (MAP increase 3–5 mm Hg), fully responsive (MAP increase >5 mm Hg).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Patients were followed up until Dec 31th 2021.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "were", "followed", "up", "until", "Dec", "31th", "2021", "." ] } ]
PMC11565047	Indeed, both androgen and estrogen receptors (respectively, AR and ERα) are ligand-activated transcription factors, being members of the nuclear receptor gene family .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11604768	Data points and error bars indicate the mean and standard deviation of technical replicates within each of three experimental replicates (n = 3 independent experiments, distinguished via color).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	R package was employed to align specific TF-gene mutants to disease phenotypes (5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "R", "package", "was", "employed", "to", "align", "specific"...
PMC9429973	We analyzed the effect of NFKBIE ablation studying in vitro cell proliferation and migration, gene expression, BcR signalling pathway, and response to treatment with the BTK inhibitor Ibrutinib.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11637284	Mini-p166-HA, in contrast to the TAC60ΔC283-myc variants, was essentially completely recovered into the SN2 fraction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mini-p166-HA", ",", "in", "contrast", "to", ...
PMC11754784	Moreover, for some functional membrane receptors, binding to ligands would immediately activate downstream signaling pathways, thus disturbing the target system and invalidating the Boolean operation process.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11350568	Incubation of AptG-1, AptG-2, Sgc8c, HG1–9, and XQ-2d for the appointed time at 37 °C allowed us to observe the superior stability of AptG-1 in 1640 culture media over the other probes, which is a crucial parameter for TMPD application (Figure 2b). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	These preclinical findings suggest a potential role of CSN5i-3 in molecular therapeutics and immunotherapy in T-cell lymphomas.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "preclinical", "findings", "suggest", "a"...
PMC11541241	This conclusion further confirmed the involvement of the TOR signalling pathway in the pathogenicity of M. oryzae.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "conclusion", "further", "confirmed", "the...
PMC11590870	However, these sometimes do not consider highly important aspects such as cellular absorption.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "these", "sometimes", "do", "not", "consider", "h...
PMC4485786	The relative expression of the transcription factors T-bet and RORC, which regulate IFN-γ and IL-17 respectively, mirrored the degree of TH1 bias in the tumor infiltrating lymphocytes of the respective cohorts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8973725	Unfortunately, for some patients, ccRCC has already metastasized by the time they are initially diagnosed, which dramatically reduces the 5-year survival rate .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11352746	The ability to screen for agents that can promote the development and/or maintenance of neuronal networks creates opportunities for the discovery of novel agents for the treatment of central nervous system (CNS) disorders.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11650848	average methylation within 6 CpG sites measured by pyrosequencing, SD standard deviation, min minimum, max maximum, N number of blood samples; significance indicated by p < 0.05 and measured by ANOVA Average methylation levels relevant to the rs365052 SNP at 11 years old Av.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11200978	Necrosis results in an unregulated swelling and bursting of cellular components, thereby stimulating an inflammatory response .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Necrosis", "results", "in", "an", "unregulated", ...
PMC10329074	The YBX3 gene was used as a template to construct a lentiviral vector for small interfering RNA (siRNA) interference by Baioujing Medical Technology Co., Ltd. After having reached ~ 30% confluence, the cells were transfected with YBX3 siRNA lentivirus or control siRNA lentivirus and cultured for a further three days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11310713	Live/dead assay was conducted following the manufacturer’s instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Live/dead", "assay", "was", "conducted", "following", "the", "manufacturer", "’s", "instructions", "." ...
PMC11767725	Emerging ML technologies provide tools to overcome many of these challenges by integrating complex datasets to predict patient-specific responses and guide treatment decisions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Emergin...
PMC9429973	PSM was performed considering a 1:1 matching without replacement and with optimal matching applying a calliper width of the propensity score set at 0.1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10933092	Recent studies have shown that mA-regulated transcripts modulate phosphoinositide 3-kinase/protein kinase B/mechanistic target of rapamycin kinase and ErbB in gastrointestinal cancer (Zhao et al., 2019) and that mA modifications play a role in tumorigenesis by affecting mRNA stability (Macari et al., 2016; Wu et al., 2...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11240448	Yet, additional information often exists.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Yet", ",", "additional", "information", "often", "exists", "." ] } ]
PMC7081114	The positive percentage of KIF21B in the cells was evaluated as follows; 0 (< 10%); 1 (10%-25%); 2 (25%-50%); 3 (50%-70%); and 4 (> 70%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11063646	This study aimed to investigate the permeation of the drug and its retention in the outer layers of the skin, specifically examining retention within the epidermis and dermis layers, facilitated by intercellular passages of the stratum corneum (SC).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	She is currently been treated with antifungal agents, whereas disease is still active.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "She", "is", "currently", "been", "treated", "with", "antifungal", ...
PMC7369657	Next, we evaluated the biosafety of CQDs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", ",", "we", "evaluated", "the", "biosafety", "of", "CQDs", "." ] } ]
PMC10482220	Anti-Rac and anti-RhoA antibodies were provided by P. Fort (Centre de Recherches de Biochimie Macromoléculaire, Montpellier, France).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Anti-Rac", "and", ...
PMC11637276	For MAP3K1 knockdown, spheroids were imaged until day 4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "MAP3K1", "knockdown", ",", "spheroids", "were", "imaged", "until", "day", "4", "." ...
PMC10907726	Volcano map of differential expressed genes after DATS treatment. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Volcano", "map", "of", "differential", "expressed", "genes", "after", "DATS", "treatment", ".", ...
PMC9429973	Aims: This study aimed to investigate the potential role of SAMHD1 in anti-tumor immune responses in cHL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "This", "study", "aimed", ...
PMC11760643	Cells were then washed once and incubated with ECS for a further 20 min to allow complete de‐esterification of the Fura‐2 AM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "wer...
PMC3164356	As a result, CHO cell lines now play a dominant role in bioprocessing research and the development of therapeutic biopharmaceuticals, delivering up to several grams per liter of these products in highly optimized production processes.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10729469	Pre-stimulated CFSE + Tresps were co-cultured with TCR Aβ-Tregs (TCR-Tregs + 0.5 μL TCR Aβ) or Tregs (polyclonal) or TCR knockout Treg (TCR-Tregs) at 1:1 ratio (50,000 cells/well) for 3 days with only MHC-Aβ-tetramer or control-tetramer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The mean anxiety score for the nine patients who wished they did not know their diagnosis was significantly higher than that for the 16 patients who desired to but did not know their diagnosis (p<0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11764090	SLR/IAA14 is a transcriptional repressor of IAA signaling and plays a crucial role in microRNA integration into IAA and cold response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SLR/IAA14", "is", ...
PMC8524093	Chikungunya virus infection is known to cause severe musculoskeletal disorder, but the molecular mechanism involved in this process is not fully understood (Maek-A-Nantawat and Silachamroon, 2009).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The median durability of response for PTCL is 133 (Q1-Q3; 69 - 280) days and for CTCL is 148 (Q1-Q3; 103 - 294) days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9621239	Therefore, the evolution of the HBV X gene is distinct between the intra-patient tumour and adjacent non-tumour tissues in patients with HCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefo...
PMC11463018	Approved HDAC inhibitors.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Approved", "HDAC", "inhibitors", "." ] } ]
PMC11745600	Therefore, β-cell regeneration from human stem cell or xenogeneic islet cell transplantation is expected to emerge as a next-generation β-cell replacement technique to mitigate issues associated with donor shortage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11786704	This suggested that PC has advantages in the treatment of chronic disease treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "suggested", "that", "PC", "has", "advantages", "in", "the", "...
PMC9509578	A recent review published by Si et al. explains the crucial role of miRNA regulation in different types of cancer .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "recent", "review", ...
PMC10362265	In line with the fluctuation analysis (Fig. 2), essential dynamics based on the first two principal components (pcs) suggested that the IL18 structures in the computational models sampled a limited conformational space (Fig. S1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721277	The reaction mass was dissolved with CH2Cl2 (20 mL) and washed with a saturated aqueous solution of NaHCO3 (2 × 10 mL).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11680982	The collective analysis revealed that while CDK4/6 inhibitor combined with endocrine therapy effectively suppressed the proliferation of both HR/HER2-0 and HR/HER2-low breast cancer cells, the inhibitory effect on HR/HER2-low breast cancer was notably attenuated compared with the HR/HER2-0 subtype (P < 0.01) (Fig. 2A,B...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9596868	Therefore, we measured the gene expression of ATM and RAD50 in cells treated MST-312, quercetin and their combination.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "we", ...
PMC7723249	The resistance (R), expressed in ohm (Ω), were obtained by subtracting the resistance of an empty membrane from the value of the membrane with growing cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767793	In contrast to chemical compounds, the biological activity of particulate nanomaterials is highly dependent on their physicochemical properties, not just their composition and concentration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11387401	A, B) Overview of four nRIPseq assays (A–D) performed on cell lines that express a single 2xStrepTagII-TEV-3xFLAG-tagged HIV-1 protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11489351	H, quantification of immunoblots prepared as in (G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "H", ",", "quantification", "of", "immunoblots", "prepared", "as", "in", "(", "G", ...
PMC10607604	HGSOC and the tumor grade were defined according to the World Health Organization criteria.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HGSOC", "and", "the", "tumor", "grade", "were", "defined", "acco...
PMC9429973	Median platelet count at diagnosis was 45 x 10/µL (range: 4-98 x 10/µL) and 20.6% of patients had bleeding at diagnosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7582629	The MDA-MB-231 and MDA-MB-435s cells showed spread morphologies, while the SK-BR-3 cell population contained both round cells and spread cells.	[ { "tags": [ "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Th...
PMC8073654	After screening several proteins implicated in apoptosis induction, it was determined that 4 upregulated the Bcl-2-associated X protein (Bax), caspase-3, cytochrome c, and the second mitochondria-derived activator of caspase and downregulated B-cell lymphoma 2 (Bcl-2), heat shock protein 70, and X-linked inhibitor of a...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806613	Right, tumor weights (MDA-MB-231: each group, n = 7; BT474: each group, n = 8).	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "...
PMC11352311	Tyrosol derivatives inhibit leukemia by promoting apoptosis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tyrosol", "derivatives", "inhibit", "leukemia", "by", "promoting", "apoptosis", "." ] } ]
PMC11705067	The R software packages "Survival" and "Survminer" perform the Kaplan-Meier (KM) survival curve analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "R", "software", ...
PMC11578343	The inlet filter removes cellular clusters or debris that might otherwise obstruct the sinusoidal contraction zones and is comprised of an array of pillars spaced w p apart.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9428827	Next, we evaluated the capacity of the IL-2 mutein to change the balance of CD8MP/Tregs in tumor-bearing mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", ",", "we", "evaluated", ...

PMC10994876

Beads are placed in specially designed reaction tubes which is used as vessel for incubation, washing, and signal processing.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Beads", "are", "p...

PMC9952933

However, a comparison of malignant bone cells and primary non-malignant bone cells with regard to possible selective in vitro effects of CAP remains elusive.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11401358

Amyloid protein was reported to change from a β-sheet structure to a random coil structure after oxidation .

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PMC7305184

4 months, to see if we can induce development of adaptive resistance in cells to PEF treatment.

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PMC10547921

Then, the suitable sites on cryptophycin were analyzed: In unit A, para-substituted phenyls are more potent than ortho-substituted or meta-substituted analogs, and the para-substituted phenyl could be used as the conjugate point; Unit B is sensitive to slight modifications, such as 5-fluoro substitution on benzene ring...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11599565

We found a significant amplification of KRT80-ChgA dual-positive cells, indicating that these rare cells in non-tumoral ovarian tissues could be the progenitors that expand to form the tumor mass (Fig. 7, Panel C, upper block of IHC pictures, OR E–H).

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PMC7642379

Indeed, the adherent progeny cell lines 293E and 293T are easier to detach by trypsinization compared to the parental HEK293, potentially through altered expression of cell adhesion, cytoskeletal and cell membrane proteins in accordance with the observed consensus changes between progeny cell lines and the parental HEK...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", ...

PMC11295144

The cells were blocked in 1% BSA in PBS for 30 min at room temperature.

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PMC11025866

The same result was previously observed for VPA .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "same", "result", "was", "previously", "observed", "for", "VPA", "." ] } ]

PMC9429973

Survival curves were compared with Log-rank test, Cox proportional hazards test was used for multivariate analysis.

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PMC7602170

Class IB PI3Ks include the catalytic subunit p110γ and regulatory subunit isoforms (p84/p87 or p101) .

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PMC7762347

Moreover, CYN and the combination with MCLR upregulated CYP1A1 and target genes involved in DNA-damage response (CDKN1A, GADD45A).

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PMC10092581

The same complex, when dissolved in 20 : 80 NaCl‐D2O(100 mM)/DMSO‐d6, showed a ratio of 67 : 33 in favor of the α‐Cl which remained stable even after 9 days (Figure S14).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11519567

However, these small molecules lack specificity for the SS18-SSX.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "these", "small", "molecules", "lack", "specificity", "for", "the", "SS18-SSX", ...

PMC11352746

Both approaches may result in a single time point since the cells are usually not viable after exposure to stains and dyes.

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PMC5854676

In addition, the immunofluorescence test was performed following assay.

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PMC11473843

Relative quantification of cell death by flow cytometry analysis of Annexin V-Atto 633 (AV) -positive + Annexin V/PI (AV/PI)-positive + PI-positive gated populations in HBEC3-FAK KO cells previously transduced as in (D); n = 4. (

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PMC11743414

P < 0.05;**P < 0.01;***P < 0.001, the difference was statistically significant.

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PMC11409031

In this study, we identified T cell subsets as characteristic cell subsets of OV by analyzing OV single-cell data.

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PMC11541409

After molecular genetic testing on tumor biopsy, careful selection and combination of approved TKIs with appropriate dosing schemes could help effectively target multiple secondary mutations in KIT/PDGFRA .

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PMC10198699

This issue is sure to be canvassed in the lawsuit filed at the end of 2021 by the estate of Henrietta Lacks against Thermo Fisher Scientific; it is likely that all profits made by the biotech company from commercializing the HeLa cell line will be claimed.

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PMC11543935

PRFS-Thermometry relies on the resonance frequency of hydrogen atoms being approximately linearly dependent on temperature in molecules with hydrogen bond-bound hydrogen at temperatures around room temperature.

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PMC9429973

This is a retrospective study conducted at American University of Beirut Medical Center (AUBMC).

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PMC9429973

Median PFS did not differ by type of salvage treatment used (p-value= 0.7).

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PMC9583612

Yet, such inventories are often a major component of any operator or government’s climate action plans.

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PMC11407042

Determine cell number 3 times using the Count Star automated cell counter.i.

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PMC11257988

Hillig et al. designed a pan-KRAS inhibitor, BAY-293, using a dual-screening approach and structure-guided design.

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PMC11012012

Coma et al. (2017) observed a downregulated expression of SLAMF2/CD48 in pathological CLL B cells when compared to normal B cells .

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PMC11194678

G and H) Left: Representative immunostaining images showing co-localization and enrichment (white arrows) of endogenous PABPC1 (red) (G) or RPL7a (red) (H) within STAU1 condensate (green) in HepG2 and COS7 cells.

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PMC8041314

In case one compound was evaluated with a definite number (e.g., 9.6 μM) and an estimation (e.g., >25 μM), the definite number was always given priority, while the estimated value was not considered.

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PMC3164356

Neu5Gc is immunogenic in humans.

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PMC11781181

With the deepening of research into the ferroptotic mechanism, many specific ferroptosis inhibitors have been identified.

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PMC10048572

Therefore, we expected to see the emergence of new aberrant clones and changes in the mutational landscape during cell culture propagation.

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PMC11701801

KREMEN2 is a single-pass transmembrane protein that plays a role in suppressing the apoptosis pathway via interaction with KREMEN1 (19, 33, 34); therefore, we examined the expression of KREMEN2 mRNA in SMARCA4/SMARCA2-deficient and SS18–SSX fusion cell lines.

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PMC11739696

The protein-bound SRB was then dissolved, and absorbance was measured at 540 nm using a BMG LABTECH-FLUO Star Omega microplate reader (Ortenberg, Germany).

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PMC11462673

The cell precipitate obtained after centrifugation was collected and was resuspended using a 100 μl wash buffer.

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PMC11545868

Under certain conditions of cellular stress, the mitochondrial outer membrane permeability (MOMP) increases, releasing cytochrome c, which interacts with an apoptosis-inducing factor called APAF1 (apoptotic peptidase activator 1) to form an apoptosome, leading to caspase-mediated cell death .

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PMC9621239

Sn at each amino acid site in genotype-B clones. (

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PMC11470381

Subsequent deeper examination enabled us to identify a similar mechanism operating during chemokine-driven, ICAM-1-dependent human CD4 T-lymphocyte migration .

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PMC9646302

The 786-0 cell line with LAPTM5 overexpression was injected into mice, and the time until tumor visualization was observed.

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PMC10545062

Instead of considering the hemodynamic response to a fluid bolus as simply a binary outcome, we expanded into three state conditions after fluid test bolus based on MAP response: nonresponsive (MAP increase <3 mm Hg), partially responsive (MAP increase 3–5 mm Hg), fully responsive (MAP increase >5 mm Hg).

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PMC9429973

Patients were followed up until Dec 31th 2021.

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PMC11565047

Indeed, both androgen and estrogen receptors (respectively, AR and ERα) are ligand-activated transcription factors, being members of the nuclear receptor gene family .

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PMC11604768

Data points and error bars indicate the mean and standard deviation of technical replicates within each of three experimental replicates (n = 3 independent experiments, distinguished via color).

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PMC9429973

R package was employed to align specific TF-gene mutants to disease phenotypes (5).

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PMC9429973

We analyzed the effect of NFKBIE ablation studying in vitro cell proliferation and migration, gene expression, BcR signalling pathway, and response to treatment with the BTK inhibitor Ibrutinib.

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PMC11637284

Mini-p166-HA, in contrast to the TAC60ΔC283-myc variants, was essentially completely recovered into the SN2 fraction.

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PMC11754784

Moreover, for some functional membrane receptors, binding to ligands would immediately activate downstream signaling pathways, thus disturbing the target system and invalidating the Boolean operation process.

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PMC11350568

Incubation of AptG-1, AptG-2, Sgc8c, HG1–9, and XQ-2d for the appointed time at 37 °C allowed us to observe the superior stability of AptG-1 in 1640 culture media over the other probes, which is a crucial parameter for TMPD application (Figure 2b). (

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PMC9429973

These preclinical findings suggest a potential role of CSN5i-3 in molecular therapeutics and immunotherapy in T-cell lymphomas.

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PMC11541241

This conclusion further confirmed the involvement of the TOR signalling pathway in the pathogenicity of M. oryzae.

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PMC11590870

However, these sometimes do not consider highly important aspects such as cellular absorption.

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PMC4485786

The relative expression of the transcription factors T-bet and RORC, which regulate IFN-γ and IL-17 respectively, mirrored the degree of TH1 bias in the tumor infiltrating lymphocytes of the respective cohorts.

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PMC8973725

Unfortunately, for some patients, ccRCC has already metastasized by the time they are initially diagnosed, which dramatically reduces the 5-year survival rate .

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PMC11352746

The ability to screen for agents that can promote the development and/or maintenance of neuronal networks creates opportunities for the discovery of novel agents for the treatment of central nervous system (CNS) disorders.

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PMC11650848

average methylation within 6 CpG sites measured by pyrosequencing, SD standard deviation, min minimum, max maximum, N number of blood samples; significance indicated by p < 0.05 and measured by ANOVA Average methylation levels relevant to the rs365052 SNP at 11 years old Av.

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PMC11200978

Necrosis results in an unregulated swelling and bursting of cellular components, thereby stimulating an inflammatory response .

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PMC10329074

The YBX3 gene was used as a template to construct a lentiviral vector for small interfering RNA (siRNA) interference by Baioujing Medical Technology Co., Ltd. After having reached ~ 30% confluence, the cells were transfected with YBX3 siRNA lentivirus or control siRNA lentivirus and cultured for a further three days.

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PMC11310713

Live/dead assay was conducted following the manufacturer’s instructions.

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PMC11767725

Emerging ML technologies provide tools to overcome many of these challenges by integrating complex datasets to predict patient-specific responses and guide treatment decisions.

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PMC9429973

PSM was performed considering a 1:1 matching without replacement and with optimal matching applying a calliper width of the propensity score set at 0.1.

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PMC10933092

Recent studies have shown that mA-regulated transcripts modulate phosphoinositide 3-kinase/protein kinase B/mechanistic target of rapamycin kinase and ErbB in gastrointestinal cancer (Zhao et al., 2019) and that mA modifications play a role in tumorigenesis by affecting mRNA stability (Macari et al., 2016; Wu et al., 2...

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PMC11240448

Yet, additional information often exists.

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PMC7081114

The positive percentage of KIF21B in the cells was evaluated as follows; 0 (< 10%); 1 (10%-25%); 2 (25%-50%); 3 (50%-70%); and 4 (> 70%).

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PMC11063646

This study aimed to investigate the permeation of the drug and its retention in the outer layers of the skin, specifically examining retention within the epidermis and dermis layers, facilitated by intercellular passages of the stratum corneum (SC).

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PMC9429973

She is currently been treated with antifungal agents, whereas disease is still active.

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PMC7369657

Next, we evaluated the biosafety of CQDs.

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PMC10482220

Anti-Rac and anti-RhoA antibodies were provided by P. Fort (Centre de Recherches de Biochimie Macromoléculaire, Montpellier, France).

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PMC11637276

For MAP3K1 knockdown, spheroids were imaged until day 4.

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PMC10907726

Volcano map of differential expressed genes after DATS treatment. (

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PMC9429973

Aims: This study aimed to investigate the potential role of SAMHD1 in anti-tumor immune responses in cHL.

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PMC11760643

Cells were then washed once and incubated with ECS for a further 20 min to allow complete de‐esterification of the Fura‐2 AM.

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PMC3164356

As a result, CHO cell lines now play a dominant role in bioprocessing research and the development of therapeutic biopharmaceuticals, delivering up to several grams per liter of these products in highly optimized production processes.

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PMC10729469

Pre-stimulated CFSE + Tresps were co-cultured with TCR Aβ-Tregs (TCR-Tregs + 0.5 μL TCR Aβ) or Tregs (polyclonal) or TCR knockout Treg (TCR-Tregs) at 1:1 ratio (50,000 cells/well) for 3 days with only MHC-Aβ-tetramer or control-tetramer.

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PMC9429973

The mean anxiety score for the nine patients who wished they did not know their diagnosis was significantly higher than that for the 16 patients who desired to but did not know their diagnosis (p<0.05).

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PMC11764090

SLR/IAA14 is a transcriptional repressor of IAA signaling and plays a crucial role in microRNA integration into IAA and cold response.

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PMC8524093

Chikungunya virus infection is known to cause severe musculoskeletal disorder, but the molecular mechanism involved in this process is not fully understood (Maek-A-Nantawat and Silachamroon, 2009).

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PMC9429973

The median durability of response for PTCL is 133 (Q1-Q3; 69 - 280) days and for CTCL is 148 (Q1-Q3; 103 - 294) days.

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PMC9621239

Therefore, the evolution of the HBV X gene is distinct between the intra-patient tumour and adjacent non-tumour tissues in patients with HCC.

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PMC11463018

Approved HDAC inhibitors.

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PMC11745600

Therefore, β-cell regeneration from human stem cell or xenogeneic islet cell transplantation is expected to emerge as a next-generation β-cell replacement technique to mitigate issues associated with donor shortage.

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PMC11786704

This suggested that PC has advantages in the treatment of chronic disease treatment.

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PMC9509578

A recent review published by Si et al. explains the crucial role of miRNA regulation in different types of cancer .

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PMC10362265

In line with the fluctuation analysis (Fig. 2), essential dynamics based on the first two principal components (pcs) suggested that the IL18 structures in the computational models sampled a limited conformational space (Fig. S1).

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PMC11721277

The reaction mass was dissolved with CH2Cl2 (20 mL) and washed with a saturated aqueous solution of NaHCO3 (2 × 10 mL).

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PMC11680982

The collective analysis revealed that while CDK4/6 inhibitor combined with endocrine therapy effectively suppressed the proliferation of both HR/HER2-0 and HR/HER2-low breast cancer cells, the inhibitory effect on HR/HER2-low breast cancer was notably attenuated compared with the HR/HER2-0 subtype (P < 0.01) (Fig. 2A,B...

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PMC9596868

Therefore, we measured the gene expression of ATM and RAD50 in cells treated MST-312, quercetin and their combination.

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PMC7723249

The resistance (R), expressed in ohm (Ω), were obtained by subtracting the resistance of an empty membrane from the value of the membrane with growing cells.

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PMC11767793

In contrast to chemical compounds, the biological activity of particulate nanomaterials is highly dependent on their physicochemical properties, not just their composition and concentration.

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PMC11387401

A, B) Overview of four nRIPseq assays (A–D) performed on cell lines that express a single 2xStrepTagII-TEV-3xFLAG-tagged HIV-1 protein.

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PMC11489351

H, quantification of immunoblots prepared as in (G).

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PMC10607604

HGSOC and the tumor grade were defined according to the World Health Organization criteria.

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PMC9429973

Median platelet count at diagnosis was 45 x 10/µL (range: 4-98 x 10/µL) and 20.6% of patients had bleeding at diagnosis.

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PMC7582629

The MDA-MB-231 and MDA-MB-435s cells showed spread morphologies, while the SK-BR-3 cell population contained both round cells and spread cells.

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PMC8073654

After screening several proteins implicated in apoptosis induction, it was determined that 4 upregulated the Bcl-2-associated X protein (Bax), caspase-3, cytochrome c, and the second mitochondria-derived activator of caspase and downregulated B-cell lymphoma 2 (Bcl-2), heat shock protein 70, and X-linked inhibitor of a...

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PMC11806613

Right, tumor weights (MDA-MB-231: each group, n = 7; BT474: each group, n = 8).

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PMC11352311

Tyrosol derivatives inhibit leukemia by promoting apoptosis .

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PMC11705067

The R software packages "Survival" and "Survminer" perform the Kaplan-Meier (KM) survival curve analysis.

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PMC11578343

The inlet filter removes cellular clusters or debris that might otherwise obstruct the sinusoidal contraction zones and is comprised of an array of pillars spaced w p apart.

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PMC9428827

Next, we evaluated the capacity of the IL-2 mutein to change the balance of CD8MP/Tregs in tumor-bearing mice.

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