OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC9429973	So far, little is known about its effects on myeloid malignancies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "So", "far", ",", "little", "is", "known", "about", "its", "effects", "on",...
PMC9429973	We next performed BH3 profiling and found LSC to be dependent on BCL2 and mature blasts on MCL1 in all samples studied.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "next",...
PMC7351993	Supplementary Fig. 5a–5d show four-color SRS spectral bases used in the imaging and sorting experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Supplementary", "Fig.", "5a–5d", "show", "four-color", "SRS", ...
PMC8164677	Median-effect dose (ED50), shape (sigmoidicity) and conformity (linear correlation coefficient) were taken as dose-effect parameters, represented as Dm, m and r as shown in Table 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9596868	No. 7352), 100 units/mL penicillin and 100 µg/mL streptomycin antibiotic solution (ScienCell Research Laboratories, Cat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No.", "7352", ")", ",", "10...
PMC11656657	Lastly, we sought to determine whether pharmacological inhibition of EZH2 could positively modulate GD2 expression in sarcoma cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lastly", ",", "we", "sought", ...
PMC11720808	The NF-κB luciferase reporter and pRL-TK Renilla luciferase construct were provided by Promega.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "NF-κB", "luciferase", "reporter", "and", "pRL-TK", "Renilla", "lucif...
PMC8345486	The cesium salts of these synthesized anions were converted into their corresponding sodium salts through metathesis and used in this study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cesium", "...
PMC11737091	Thus, when DBF4 levels are high, DBF4 may bind to CDC7 and activate it to initiate DNA replication .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "when", "D...
PMC10335954	1Overexpression of TRIP13 in gastric malignancy and its association with the inferior prognosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "1Overexpression", "of", "TRIP13", "in", "gastric", "malignancy", "and", "it...
PMC11750165	Scale bar; 25 µm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ";", "25", "µm", "." ] } ]
PMC9429973	The median age was 37 years(range 15-72 years, male 56.6%, female-37%).93 patients (62.4%) were stratified as low risk and 56 patients (37.5%) as high risk based on Sanz’s score.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9817179	For example, individual POI molecules at the surface and interior of a punctum might dissociate with different rates, but our model does not differentiate these molecules.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11544122	b Agonist-stimulated endocytosis of CXCR4, β2AR, AT1AR, V2R, CXCR5, and CXCR7/ACKR3 was examined in parental HEK293 cells transfected with control siRNA or SNX9 KO #2 HEK293 cells transfected with siRNA against SNX18 (18-1) (SNX9-KO/18si).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", ...
PMC11762280	We obtained data for statistical analysis from at least three independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "obtained", "data", "for", "statistical", "analysis", "from", "at", "least"...
PMC11591038	Palmitic acid-BSA (PA-BSA) treatment stimulates BACE1 expression in astrocytes with elevated oxidative stress .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Palmitic", "acid-BSA", "(", "PA-BSA", ")", "treatment", "st...
PMC10578720	n=3, p<0.01, *p<0.001 (1-way ANOVA with Tukey post hoc test).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "n=3", ",", "", "", "p<0.0...
PMC11680982	For HER2-low tumor volume on day 14: normal saline vs. ET + CDK4/6i, P = 0.009; normal saline vs. standard dose ET + CDK4/6i + Ner, P = 0.0003.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11705484	p < .05, p < .01 and * p < .001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", ".05", ",", "", "", "p", "<", ...
PMC6835762	The variation of both the fatty acid nature (butyrate, octanoate, laurate, stearate, behenate and oleate) and degrees of substitution have been analyzed for their influence on the final polymer amphiphilic balance, affecting NP shape, drug interactions, NP metabolism and cell uptake .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11473750	We recently identified Proliferation-Associated protein 2G4 (PA2G4) as a direct protein-binding partner of MYCN which acts in a forward feedback expression loop with MYCN to drive neuroblastoma tumourigenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11454387	Next, we analyzed enriched biotinylated proteins by mass spectrometry and further assessed potential candidates by co-immunoprecipitation and functional assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", ",", "we", "ana...
PMC11696576	In PBMCs, the calcium ionophore A23187 stimulated the release of PGE2, TXB2, LTB4, 6-keto prostaglandin F1α (PGF1α), and 12-HETE.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11046454	With its optimal performance, AptPTK7-T15-functionalized CAR-T was used as the optimal desgin and simply termed as AptPTK7-CAR-T in subsequent studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", "its", "op...
PMC9545474	C NMR (100 MHz, D2O): δ 137.34 (CHarom), 134.97 (C17), 133.09 (C15), 129.84 (CHarom), 128.79 (C11), 126.90 (C8), 123.92 (CHarom), 117.61 (C5 and C9), 109.61 (CF3), 95.90 (C3), 91.50 (C4), 30.15 (C6), 21.59 (C7), 17.76 (C1) ppm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11502962	Summarily, CD8, CD68, CD206, MIF, and CXCR4 expression are related with tumor progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summarily", ",", "CD8", ",", "CD68", ...
PMC8343815	The researchers revealed that the viability of KB cells, which were treated with radiotherapy alone or 15 µg/mL of AuNRs during radiotherapy, was 81.6% and 55.1%, respectively .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767725	Chronic hyperglycemia exacerbates insulin resistance through glucotoxicity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chronic", "hyperglycemia", "exacerbates", "insulin", "resistance", "through", "glucotoxicity", "." ] } ]
PMC11435360	It is also important to note that we observed the development of MIBC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "also", "important", "to", "note", "that", "we", "observed...
PMC8701144	In adenovirus-infected cells, the E1B-55k protein typically assembles with the viral E4 Orf6 protein along with cellular proteins to form a virus specific E3 ubiquitin ligase that regulates the degradation of cellular proteins such as TP53, MRE11, DNA ligase IV and BLM that constrain viral replication.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11422497	Furthermore, in order to investigate the impact of miR-494-3p on GISTs, we successfully constructed miR-494-3p mimic and inhibitor and subsequently stably transfected them into GIST-T1 and GIST-882 cells using Lipofectamine (P < 0.05; Fig. 4A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11615101	The cells were lysed and centrifuged (30min, 11,000 × g, 4°C), and the supernatant was allowed to pass through control agarose beads.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11320834	Olaparib-loaded liposomes (OLLs) and corresponding non-loaded formulations (NLs) were prepared by thin lipid hydration with passive drug loading during hydration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Methods: 79 patient-derived AML cell samples from diagnosis were thawed after preservation in liquid nitrogen and cultured at standard in vitro methods with the Rac1-inhibitors ZINC69391, ITX3, EHOP-16, 1A-116, and NSC23766.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10890307	Doublets and debris were excluded.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Doublets", "and", "debris", "were", "excluded", "." ] } ]
PMC6222726	No biological data for this compound have been reported.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "biological", "data", "for", "this", "compound", "have", "been", "reported", "." ] } ]
PMC11387401	The experiment was performed once with three technical replicates for the on-target ASO-treated conditions and six technical replicates for the scrambled controls.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "exper...
PMC9964654	The amounts of [Au(cdc)2] and polymer used were maintained at 2 mg and 25 mg, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "amounts", "of", "[", ...
PMC11013014	They were utilised without additional purification.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "were", "utilised", "without", "additional", "purification", "." ] } ]
PMC9429973	Median follow-up was 71 months and 5y-OS and 5y-PFS were 74% and 67%, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "follow-up", "was", "71", "months", ...
PMC11345828	NaHCO3, water, and brine.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NaHCO3", ",", "water", ",", "and", "brine", "." ] } ]
PMC11366496	From Beijing Vital River Animal Technology Co. Ltd. (Beijing, China), 30 nude mice (6–8 weeks, female) were purchased.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11359735	The sequences of the C-termini of CSP from different Plasmodium species are shown, beginning at the basic residues after the type I thrombospondin repeat (TSR).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11604768	For those interested, the reported LRT statistics can be converted to p-values using a chi-square distribution with one degree of freedom, according to Wilks’ theorem.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	None of the patients were active smokers or had chronic lung disease when admitted.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "None", "of", "the", "patients", "were", "active", "smokers", "or...
PMC10040136	Following 48 h of incubation, 10 μl of CCK-8 solution was added to each well, followed by an additional 2-h culture at 37 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11785489	Method 2: Logistic Regression with Ridge Penalty Results from rCCA clearly pointed to four recognizable T cell states.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Method", "2", ":", "Logistic", ...
PMC9429973	Methods: Our retrospective study involved all patients diagnosed with PB-DLBCL at the hematology department of Sfax between January 2008 and December 2019.We studied the diagnostic characteristics of these patients: age, sex andclinical features.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11279598	Primary antibodies were from Cell Signaling Technology (Beverly, MA, USA): (ADP-Ribose) polymerase (PARP) (#9542), STAT3 (#12640), pAktSer473 (#9271), Akt #9272, pAMPKThr172 (#2535), AMPK #2532, pS6 ribosomal protein ser235/236 (#2211), S6 (#2217), and Active Motif anti-Ser727-phosphorylated STAT3 cat# 39613, dil 1:100...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8992508	The introduction of a methoxy group at phenyl ring B exerted a slightly positive effect on the activity since compound 74 showed a similar activity than the corresponding analogue without that substituent (75), previously reported (IC50 = 0.0774 and 0.106 M, respectively).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11279397	Additionally, β-sitosterol acted as a potent inhibitor of white spot syndrome virus (WSSV), significantly reducing viral load and viral gene transcription levels while improving survival in crayfish infected with WSSV .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11768281	Some studies also involved immunized murine models with P. falciparum sporozoites to simulate immune responses relevant to human malaria.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "studies", "also", "involv...
PMC11742290	High LGR5 expression in ovarian cancer was found to be associated with high vasohibin-1 (angiogenesis inhibiting protein-1, infiltration & metastasis marker) expression, a protein associated with early infiltration and metastasis in many cancers .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11805741	Similarly, carotenoids extracted from Halophilic Archaeon, Haloarcula sp. Showed high cytotoxicity on breast cancer cell line with IC50 = 0.0625 mg/mL (Shahbazi et al. 2023).Bacterial carotenoids have also shown potent anticancer activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", ...
PMC11627060	Visual inspection of the extracted TQ revealed no apparent changes in its chemical composition following treatment, as indicated by minimal to no alterations in concentration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11532793	The residual degrees of freedom determine the precision with which the RTA-dispersions are estimated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "residual", "degrees", "of", "freedom", "determine", "the", ...
PMC9429973	Currently, a randomised clinical study is being conducted in 4 European countries to evaluate the proposed intervention and its potential impact on patients’ QoL. Results: Based on this experience, a number of key issues have emerged: (a) while patients are generally positive about the use of eHealth, they are still re...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11577421	Apparent values of binding affinity (KD) are annotated near each fit.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Apparent", "values", "of", "binding", "affinity", "(", "KD", ")", "ar...
PMC10729469	Cognitive function evaluated by F-FDG PET is considered an imaging biomarker for AD [86–88].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cognitive", "function", "evaluated", "by", "F-FDG", "P...
PMC11621565	Regarding the measurement of α-synuclein levels, although SH-SY5Y is a simple neuronal in vitro model, a significant advantage of this study is the use of a cell line that was not genetically modified to overexpress α-synuclein or to express an altered protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	PK deficiency has wide genetic heterogeneity, with >300 mutations reported, and previous data suggest that disease complications may be common regardless of genotype.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC3734024	Here, we extensively characterized the surface phenotype of FasL killer B cells, showing they are enriched in the IgMCD5CD1d B cell subset previously reported to contain a higher frequency of B cells producing interleukin-10 (IL-10).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11739484	The up-regulation of MMP7, MMP11, and MMP14 in cancer is a multifaceted phenomenon, intricately linked to various aspects of tumor progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11686380	Growth-associated protein 43 (GAP43) is a membrane-associated phosphoprotein predominantly expressed in the nervous systems, and controls axonal growth, branching, and pathfinding.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC3734024	As IL-21 is associated with the growth of follicular B cells, it is possible that IL-21 drives the growth of B-2-derived regulatory B cells, while IL-5 induces the growth of B-1-derived regulatory B cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11509224	Moreover, compound 42 inhibited the growth of planktonic forms of the biofilm-forming bacteria Staphylococcus epidermidis (MIC < 0.0877 µM), but it did not inhibit biofilm formation, whereas compound 43 showed the opposite activity profile and inhibited only biofilm formation but not bacterial growth.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Suge-related AEs occurred in 61 (76%) pts and were mostly (60%) Grade 1 or 2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Suge-related", "AEs", ...
PMC11612794	We examined GFP-Dsn1 levels at kinetochores in CENP-C/CENP-T cells and found that GFP-Dsn1 levels were significantly reduced compared to those in CENP-C/CENP-T cells (∼70% of those in CENP-C/CENP-T cells; Figures 5C and 5D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594074	The known DNMT1 inhibitor RG108 was used as a positive control and displayed an inhibition value of 70.5%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "known", "DNMT1", "inhibito...
PMC9429973	The highest rate of recurrent events per 100 years was seen in the group with unexplained elevated platelets (8.11, 95% CI 2.37-13.84).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11045125	EBV-neg and EBV+ Akata BL cells serve as a negative control.	[ { "tags": [ "O", "O", "O", "B-CellLine", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "EBV-neg", "and", "EBV+", "Akata", "BL", "cells", "serve", "as", "a", ...
PMC11672617	However, unlike the latter, it demonstrated selective toxicity against the studied cell lines with high reliability (p < 0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However...
PMC8193046	Regarding structure-based design through molecular docking approaches, ABCB1 , , and ABCG2 , , are most pronounced, but also ABCC4 or ABCC5 , have been investigated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Median time to first OR, duration of CR (DCR), duration of OR, and progression-free survival (PFS) were 1.9, 11.1, 9.8, and 11.6 mo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8839885	Interestingly, exposure of OC cells to 2HE2 alone had minimal effect on apoptosis induction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "exposure", "of", "OC", "cells", "to",...
PMC10094992	Here we describe that treatment with the highly selective ALDH1A3 inhibitor, NR6, impaired the growth of ALDH1A3 positive MPM cells cultured as multicellular spheroids (MCSs).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11522251	The effectiveness of transfection was assessed by protein blotting analysis and qRT-PCR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "effectiveness", "of", "transfection", "was", "assessed", "by", "protein", ...
PMC9429973	Sequencing was performed by NovaSeq 6000 (Illumina, SP flow cell, 2x150bp chemistry) and data processing of FASTQ files via in-house bioinformatic pipeline incorporating fgbio (for UMI de-duplexing, Fulcrumgenomics), VarDict for variant calling and CNVkit for copy number analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11342785	Detailed inspection of this process revealed that droplet hubs were the initial sites of MT interaction (Fig. 5C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Detailed", "inspection", "of...
PMC8469018	In our study, there were no significant changes in DHODH gene expression after teriflunomide treatment in the concentration range from 100 to 500 µM. Cell cycle analysis results also indicate the DHODH- independent toxicity of teriflunomide in multiple myeloma cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11544122	Lysates were sonicated and clarified by centrifugation at 14,000 rpm (24,104g) for 30 min at 4 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lysates", "were", ...
PMC9429973	Results: A total of 76 pts with a median age of 38 years (yrs) (range, 18-80) were identified, of which 70% were males and 81% were of Hispanic ethnicity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10578720	Left: representative confocal images of the co-localization of SIRT3 with CS (D) and PDHC (E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Left", ":", "representative"...
PMC8348645	The presence of flavonoids and terpenoids were previously reported for their anti-microbial, anti-mutagenic, anti-inflammatory and anti-allergic activities in various studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "prese...
PMC10988808	G Nuclear levels of YAP protein, using Lamin B1 as reference.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "G", "Nuclear", "levels", "of", "YAP", "protein", ",", "using", "Lamin", "B...
PMC8316344	TFRC was measured by qPCR and IB in Bel-7404 cells with or without TRIB2 knocked out (A) and in SK-Hep1 cells with or without TRIB2 overexpressed (B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "...
PMC9119314	The structure was solved within the Olex2 system using SHELXT and refined using SHELX with an R-factor of 0.027, showing a high level of agreement between the refined structure and the observed data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11629192	The CSF and the serum anti-NMDAR antibody titer decreased to 1:32 and 1:320, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "CSF", "and", "the", "serum", "anti-NMDAR", "antibody...
PMC11247842	Using single nucleotide polymorphism (SNP) array genotypes, many association studies have been conducted to identify genetic factors affecting SCS, while CM has rarely been considered for such studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11502443	In order to consider the contribution of both agonist potency and Emax to differences in agonist activity, transduction coefficients (log (τ/KA) were determined.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9917080	They are also highly resistant to apoptosis during chemotherapy .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "are", "also", "highly", "resistant", "to", "apoptosis", "during", "chemotherapy", "." ] } ]
PMC9429973	Figure 1 B) 3.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "1", "B", ")", "3", "." ] } ]
PMC2196094	The open reading frame of 822 bp encodes a signal sequence of 18 aa, a 10-aa activation peptide (Ala-Phe-Ser-Leu-Ala-Met-Phe-Arg-Glu-Gly), and the entire coding region for the mature protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6684588	administration of ACE-083 (100 µg) in the TA muscle of wild-type (C57BL/6J) mice twice weekly for 4 weeks increased the weight of the injected muscle by approximately 75% compared to vehicle (PBS) or the contralateral, uninjected TA (Fig. 3a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8193813	This method requires the fuel higher heating value and an F factor (gas volume per fuel energy content, e.g., m kcal, ft BTU) to complete the calculation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11676169	Human embryonic kidney (HEK) 293T cells and U2OS cells were obtained from the American Type Culture Collection (ATCC).	[ { "tags": [ "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O...
PMC11585587	The BCA protein quantitative kit was obtained from Vazyme (China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "BCA", "protein", "quantitative", "kit", "was", "obtained", "from", "Vazym...
PMC11394112	In U2932-Luc cell-injected NSG mice, BL signals were shown in some mice (15/30 mice), whereas tumor growth in VAL-Luc-injected NSG mice rapidly progressed, and all the mice died by the 3rd week (Figure 1A,C).	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "...
PMC11317131	Therefore, each cycle of phage replication generates a new mutation library from the fittest variants of the previous library.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "each", ...
PMC9599726	SLC7A11 is one of the two subunits of the cystine–glutamate antiporter system Xc that imports extracellular cystine into the cytoplasm, where it is used in the biosynthesis of GSH, the cofactor of the antioxidant enzyme GPX4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

So far, little is known about its effects on myeloid malignancies.

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PMC9429973

We next performed BH3 profiling and found LSC to be dependent on BCL2 and mature blasts on MCL1 in all samples studied.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "next",...

PMC7351993

Supplementary Fig. 5a–5d show four-color SRS spectral bases used in the imaging and sorting experiments.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Supplementary", "Fig.", "5a–5d", "show", "four-color", "SRS", ...

PMC8164677

Median-effect dose (ED50), shape (sigmoidicity) and conformity (linear correlation coefficient) were taken as dose-effect parameters, represented as Dm, m and r as shown in Table 1.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9596868

No. 7352), 100 units/mL penicillin and 100 µg/mL streptomycin antibiotic solution (ScienCell Research Laboratories, Cat.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No.", "7352", ")", ",", "10...

PMC11656657

Lastly, we sought to determine whether pharmacological inhibition of EZH2 could positively modulate GD2 expression in sarcoma cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lastly", ",", "we", "sought", ...

PMC11720808

The NF-κB luciferase reporter and pRL-TK Renilla luciferase construct were provided by Promega.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "NF-κB", "luciferase", "reporter", "and", "pRL-TK", "Renilla", "lucif...

PMC8345486

The cesium salts of these synthesized anions were converted into their corresponding sodium salts through metathesis and used in this study.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cesium", "...

PMC11737091

Thus, when DBF4 levels are high, DBF4 may bind to CDC7 and activate it to initiate DNA replication .

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PMC10335954

1Overexpression of TRIP13 in gastric malignancy and its association with the inferior prognosis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "1Overexpression", "of", "TRIP13", "in", "gastric", "malignancy", "and", "it...

PMC11750165

Scale bar; 25 µm.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ";", "25", "µm", "." ] } ]

PMC9429973

The median age was 37 years(range 15-72 years, male 56.6%, female-37%).93 patients (62.4%) were stratified as low risk and 56 patients (37.5%) as high risk based on Sanz’s score.

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PMC9817179

For example, individual POI molecules at the surface and interior of a punctum might dissociate with different rates, but our model does not differentiate these molecules.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11544122

b Agonist-stimulated endocytosis of CXCR4, β2AR, AT1AR, V2R, CXCR5, and CXCR7/ACKR3 was examined in parental HEK293 cells transfected with control siRNA or SNX9 KO #2 HEK293 cells transfected with siRNA against SNX18 (18-1) (SNX9-KO/18si).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", ...

PMC11762280

We obtained data for statistical analysis from at least three independent experiments.

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PMC11591038

Palmitic acid-BSA (PA-BSA) treatment stimulates BACE1 expression in astrocytes with elevated oxidative stress .

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PMC10578720

n=3, **p<0.01, ***p<0.001 (1-way ANOVA with Tukey post hoc test).

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PMC11680982

For HER2-low tumor volume on day 14: normal saline vs. ET + CDK4/6i, P = 0.009; normal saline vs. standard dose ET + CDK4/6i + Ner, P = 0.0003.

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PMC11705484

p < .05, **p < .01 and *** p < .001.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", ".05", ",", "*", "*", "p", "<", ...

PMC6835762

The variation of both the fatty acid nature (butyrate, octanoate, laurate, stearate, behenate and oleate) and degrees of substitution have been analyzed for their influence on the final polymer amphiphilic balance, affecting NP shape, drug interactions, NP metabolism and cell uptake .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11473750

We recently identified Proliferation-Associated protein 2G4 (PA2G4) as a direct protein-binding partner of MYCN which acts in a forward feedback expression loop with MYCN to drive neuroblastoma tumourigenesis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11454387

Next, we analyzed enriched biotinylated proteins by mass spectrometry and further assessed potential candidates by co-immunoprecipitation and functional assays.

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PMC11696576

In PBMCs, the calcium ionophore A23187 stimulated the release of PGE2, TXB2, LTB4, 6-keto prostaglandin F1α (PGF1α), and 12-HETE.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11046454

With its optimal performance, AptPTK7-T15-functionalized CAR-T was used as the optimal desgin and simply termed as AptPTK7-CAR-T in subsequent studies.

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PMC9545474

C NMR (100 MHz, D2O): δ 137.34 (CHarom), 134.97 (C17), 133.09 (C15), 129.84 (CHarom), 128.79 (C11), 126.90 (C8), 123.92 (CHarom), 117.61 (C5 and C9), 109.61 (CF3), 95.90 (C3), 91.50 (C4), 30.15 (C6), 21.59 (C7), 17.76 (C1) ppm.

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PMC11502962

Summarily, CD8, CD68, CD206, MIF, and CXCR4 expression are related with tumor progression.

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PMC8343815

The researchers revealed that the viability of KB cells, which were treated with radiotherapy alone or 15 µg/mL of AuNRs during radiotherapy, was 81.6% and 55.1%, respectively .

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PMC11767725

Chronic hyperglycemia exacerbates insulin resistance through glucotoxicity.

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PMC11435360

It is also important to note that we observed the development of MIBC.

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PMC8701144

In adenovirus-infected cells, the E1B-55k protein typically assembles with the viral E4 Orf6 protein along with cellular proteins to form a virus specific E3 ubiquitin ligase that regulates the degradation of cellular proteins such as TP53, MRE11, DNA ligase IV and BLM that constrain viral replication.

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PMC11422497

Furthermore, in order to investigate the impact of miR-494-3p on GISTs, we successfully constructed miR-494-3p mimic and inhibitor and subsequently stably transfected them into GIST-T1 and GIST-882 cells using Lipofectamine (P < 0.05; Fig. 4A).

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PMC11615101

The cells were lysed and centrifuged (30min, 11,000 × g, 4°C), and the supernatant was allowed to pass through control agarose beads.

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PMC11320834

Olaparib-loaded liposomes (OLLs) and corresponding non-loaded formulations (NLs) were prepared by thin lipid hydration with passive drug loading during hydration.

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PMC9429973

Methods: 79 patient-derived AML cell samples from diagnosis were thawed after preservation in liquid nitrogen and cultured at standard in vitro methods with the Rac1-inhibitors ZINC69391, ITX3, EHOP-16, 1A-116, and NSC23766.

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PMC10890307

Doublets and debris were excluded.

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PMC6222726

No biological data for this compound have been reported.

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PMC11387401

The experiment was performed once with three technical replicates for the on-target ASO-treated conditions and six technical replicates for the scrambled controls.

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PMC9964654

The amounts of [Au(cdc)2] and polymer used were maintained at 2 mg and 25 mg, respectively.

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PMC11013014

They were utilised without additional purification.

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PMC9429973

Median follow-up was 71 months and 5y-OS and 5y-PFS were 74% and 67%, respectively.

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PMC11345828

NaHCO3, water, and brine.

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PMC11366496

From Beijing Vital River Animal Technology Co. Ltd. (Beijing, China), 30 nude mice (6–8 weeks, female) were purchased.

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PMC11359735

The sequences of the C-termini of CSP from different Plasmodium species are shown, beginning at the basic residues after the type I thrombospondin repeat (TSR).

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PMC11604768

For those interested, the reported LRT statistics can be converted to p-values using a chi-square distribution with one degree of freedom, according to Wilks’ theorem.

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PMC9429973

None of the patients were active smokers or had chronic lung disease when admitted.

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PMC10040136

Following 48 h of incubation, 10 μl of CCK-8 solution was added to each well, followed by an additional 2-h culture at 37 °C.

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PMC11785489

Method 2: Logistic Regression with Ridge Penalty Results from rCCA clearly pointed to four recognizable T cell states.

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PMC9429973

Methods: Our retrospective study involved all patients diagnosed with PB-DLBCL at the hematology department of Sfax between January 2008 and December 2019.We studied the diagnostic characteristics of these patients: age, sex andclinical features.

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PMC11279598

Primary antibodies were from Cell Signaling Technology (Beverly, MA, USA): (ADP-Ribose) polymerase (PARP) (#9542), STAT3 (#12640), pAktSer473 (#9271), Akt #9272, pAMPKThr172 (#2535), AMPK #2532, pS6 ribosomal protein ser235/236 (#2211), S6 (#2217), and Active Motif anti-Ser727-phosphorylated STAT3 cat# 39613, dil 1:100...

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PMC8992508

The introduction of a methoxy group at phenyl ring B exerted a slightly positive effect on the activity since compound 74 showed a similar activity than the corresponding analogue without that substituent (75), previously reported (IC50 = 0.0774 and 0.106 M, respectively).

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PMC11279397

Additionally, β-sitosterol acted as a potent inhibitor of white spot syndrome virus (WSSV), significantly reducing viral load and viral gene transcription levels while improving survival in crayfish infected with WSSV .

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PMC11768281

Some studies also involved immunized murine models with P. falciparum sporozoites to simulate immune responses relevant to human malaria.

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PMC11742290

High LGR5 expression in ovarian cancer was found to be associated with high vasohibin-1 (angiogenesis inhibiting protein-1, infiltration & metastasis marker) expression, a protein associated with early infiltration and metastasis in many cancers .

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PMC11805741

Similarly, carotenoids extracted from Halophilic Archaeon, Haloarcula sp. Showed high cytotoxicity on breast cancer cell line with IC50 = 0.0625 mg/mL (Shahbazi et al. 2023).Bacterial carotenoids have also shown potent anticancer activity.

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PMC11627060

Visual inspection of the extracted TQ revealed no apparent changes in its chemical composition following treatment, as indicated by minimal to no alterations in concentration.

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PMC11532793

The residual degrees of freedom determine the precision with which the RTA-dispersions are estimated.

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PMC9429973

Currently, a randomised clinical study is being conducted in 4 European countries to evaluate the proposed intervention and its potential impact on patients’ QoL. Results: Based on this experience, a number of key issues have emerged: (a) while patients are generally positive about the use of eHealth, they are still re...

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PMC11577421

Apparent values of binding affinity (KD) are annotated near each fit.

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PMC10729469

Cognitive function evaluated by F-FDG PET is considered an imaging biomarker for AD [86–88].

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PMC11621565

Regarding the measurement of α-synuclein levels, although SH-SY5Y is a simple neuronal in vitro model, a significant advantage of this study is the use of a cell line that was not genetically modified to overexpress α-synuclein or to express an altered protein.

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PMC9429973

PK deficiency has wide genetic heterogeneity, with >300 mutations reported, and previous data suggest that disease complications may be common regardless of genotype.

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PMC3734024

Here, we extensively characterized the surface phenotype of FasL killer B cells, showing they are enriched in the IgMCD5CD1d B cell subset previously reported to contain a higher frequency of B cells producing interleukin-10 (IL-10).

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PMC11739484

The up-regulation of MMP7, MMP11, and MMP14 in cancer is a multifaceted phenomenon, intricately linked to various aspects of tumor progression.

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PMC11686380

Growth-associated protein 43 (GAP43) is a membrane-associated phosphoprotein predominantly expressed in the nervous systems, and controls axonal growth, branching, and pathfinding.

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PMC3734024

As IL-21 is associated with the growth of follicular B cells, it is possible that IL-21 drives the growth of B-2-derived regulatory B cells, while IL-5 induces the growth of B-1-derived regulatory B cells.

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PMC11509224

Moreover, compound 42 inhibited the growth of planktonic forms of the biofilm-forming bacteria Staphylococcus epidermidis (MIC < 0.0877 µM), but it did not inhibit biofilm formation, whereas compound 43 showed the opposite activity profile and inhibited only biofilm formation but not bacterial growth.

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PMC9429973

Suge-related AEs occurred in 61 (76%) pts and were mostly (60%) Grade 1 or 2.

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PMC11612794

We examined GFP-Dsn1 levels at kinetochores in CENP-C/CENP-T cells and found that GFP-Dsn1 levels were significantly reduced compared to those in CENP-C/CENP-T cells (∼70% of those in CENP-C/CENP-T cells; Figures 5C and 5D).

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PMC11594074

The known DNMT1 inhibitor RG108 was used as a positive control and displayed an inhibition value of 70.5%.

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PMC9429973

The highest rate of recurrent events per 100 years was seen in the group with unexplained elevated platelets (8.11, 95% CI 2.37-13.84).

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PMC11045125

EBV-neg and EBV+ Akata BL cells serve as a negative control.

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PMC11672617

However, unlike the latter, it demonstrated selective toxicity against the studied cell lines with high reliability (p < 0.05).

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PMC8193046

Regarding structure-based design through molecular docking approaches, ABCB1 , , and ABCG2 , , are most pronounced, but also ABCC4 or ABCC5 , have been investigated.

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PMC9429973

Median time to first OR, duration of CR (DCR), duration of OR, and progression-free survival (PFS) were 1.9, 11.1, 9.8, and 11.6 mo.

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PMC8839885

Interestingly, exposure of OC cells to 2HE2 alone had minimal effect on apoptosis induction.

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PMC10094992

Here we describe that treatment with the highly selective ALDH1A3 inhibitor, NR6, impaired the growth of ALDH1A3 positive MPM cells cultured as multicellular spheroids (MCSs).

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PMC11522251

The effectiveness of transfection was assessed by protein blotting analysis and qRT-PCR.

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PMC9429973

Sequencing was performed by NovaSeq 6000 (Illumina, SP flow cell, 2x150bp chemistry) and data processing of FASTQ files via in-house bioinformatic pipeline incorporating fgbio (for UMI de-duplexing, Fulcrumgenomics), VarDict for variant calling and CNVkit for copy number analysis.

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PMC11342785

Detailed inspection of this process revealed that droplet hubs were the initial sites of MT interaction (Fig. 5C).

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PMC8469018

In our study, there were no significant changes in DHODH gene expression after teriflunomide treatment in the concentration range from 100 to 500 µM. Cell cycle analysis results also indicate the DHODH- independent toxicity of teriflunomide in multiple myeloma cell line.

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PMC11544122

Lysates were sonicated and clarified by centrifugation at 14,000 rpm (24,104g) for 30 min at 4 °C.

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PMC9429973

Results: A total of 76 pts with a median age of 38 years (yrs) (range, 18-80) were identified, of which 70% were males and 81% were of Hispanic ethnicity.

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PMC10578720

Left: representative confocal images of the co-localization of SIRT3 with CS (D) and PDHC (E).

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PMC8348645

The presence of flavonoids and terpenoids were previously reported for their anti-microbial, anti-mutagenic, anti-inflammatory and anti-allergic activities in various studies.

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PMC10988808

G Nuclear levels of YAP protein, using Lamin B1 as reference.

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PMC8316344

TFRC was measured by qPCR and IB in Bel-7404 cells with or without TRIB2 knocked out (A) and in SK-Hep1 cells with or without TRIB2 overexpressed (B).

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PMC9119314

The structure was solved within the Olex2 system using SHELXT and refined using SHELX with an R-factor of 0.027, showing a high level of agreement between the refined structure and the observed data.

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PMC11629192

The CSF and the serum anti-NMDAR antibody titer decreased to 1:32 and 1:320, respectively.

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PMC11247842

Using single nucleotide polymorphism (SNP) array genotypes, many association studies have been conducted to identify genetic factors affecting SCS, while CM has rarely been considered for such studies.

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PMC11502443

In order to consider the contribution of both agonist potency and Emax to differences in agonist activity, transduction coefficients (log (τ/KA) were determined.

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PMC9917080

They are also highly resistant to apoptosis during chemotherapy .

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PMC9429973

Figure 1 B) 3.

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PMC2196094

The open reading frame of 822 bp encodes a signal sequence of 18 aa, a 10-aa activation peptide (Ala-Phe-Ser-Leu-Ala-Met-Phe-Arg-Glu-Gly), and the entire coding region for the mature protein.

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PMC6684588

administration of ACE-083 (100 µg) in the TA muscle of wild-type (C57BL/6J) mice twice weekly for 4 weeks increased the weight of the injected muscle by approximately 75% compared to vehicle (PBS) or the contralateral, uninjected TA (Fig. 3a).

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PMC8193813

This method requires the fuel higher heating value and an F factor (gas volume per fuel energy content, e.g., m kcal, ft BTU) to complete the calculation.

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PMC11676169

Human embryonic kidney (HEK) 293T cells and U2OS cells were obtained from the American Type Culture Collection (ATCC).

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PMC11585587

The BCA protein quantitative kit was obtained from Vazyme (China).

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PMC11394112

In U2932-Luc cell-injected NSG mice, BL signals were shown in some mice (15/30 mice), whereas tumor growth in VAL-Luc-injected NSG mice rapidly progressed, and all the mice died by the 3rd week (Figure 1A,C).

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PMC11317131

Therefore, each cycle of phage replication generates a new mutation library from the fittest variants of the previous library.

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PMC9599726

SLC7A11 is one of the two subunits of the cystine–glutamate antiporter system Xc that imports extracellular cystine into the cytoplasm, where it is used in the biosynthesis of GSH, the cofactor of the antioxidant enzyme GPX4.

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