OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC10914904	Some svtRNAs can be loaded into AGO2, regulating posttranscriptional gene silencing The human vault RNAs biogenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "svtRNAs", "can", "be", "loaded", "i...
PMC11541241	Various Arabidopsis mutants were impaired in TOR signalling, and plants treated with TOR inhibitor PP242 exhibited enhanced resistance to F. graminearum infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Various...
PMC11670407	Then 195 μL of Annexin V-FITC conjugate was added and mixed, and 5 μL of Annexin V-FITC and 10 μL of PI staining solution was added and gently mixed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11621493	Tissues were analyzed in 2–4 biological replicates. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tissues", "were", "analyzed", "in", "2–4", "biological", "replicates", ".", "(" ] } ]
PMC10831439	For the second and third stimulations, a more concise effect of the PD-L1/2 expression on cytotoxicity could be observed compared with the first round (figure 3E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2196094	To determine mRNA frequencies for the various proteases expressed by normal tissue MCs, an unamplified peritoneal MC cDNA library was screened with a panel of monospecific cDNA probes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7709199	The model was refined by ten cycles of rigid-body refinement followed by iterative cycles of restrained refinement and manual model corrections.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "model", "w...
PMC11451940	These cellular effects resemble the effect of zinc on esophageal squamous cancer cell line EC109, leading to the induction of autophagy and apoptosis by the upregulation of wild-type p53-induced gene 1 (WIG-1), a kind of zinc finger protein, which can further be altering the expression of Bax, p21 (WAF), and cyclin D1 ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11244823	After washing the membrane with PBS-T for 10 minutes, it was incubated overnight at 4°C with anti-V5 antibody (1:5’000; Invitrogen).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11185260	Although up to 20% of human cancers contain a loss-of-function mutation in the SWI/SNF complex, its role in tumor suppression remains understudied.10 It was only recent that several studies have revealed that SMARCB1 is a tumor suppressor with its loss required for rhabdoid tumorigenesis.3,11 The precise mechanism thro...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11759543	The combination effect of doxorubicin and vorinostat after 24 h treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "combination", "effect", "of", "doxorubicin", "and", "vorinostat", "after", "24", ...
PMC8973085	Yellow solid (87%); mp 220–222 °C (EtOH); IR (KBr, v, cm): 3259 (NH), 3235 (NH), 2221 (CN), 1676 (C=O), 1650 (C=O); H NMR (DMSO-d6): δ 2.43 (s, 3H, CH3), 2.66 (s, 3H, CH3), 3.63(s, 3H, OCH3), 3.71 (s, 3H, OCH3), 7.12–7.76 (m, 11H, CH-Ar), 9.51 (bs, 1H, NH), 10.62 (bs, 1H, NH); C NMR (DMSO-d6): δ 20.80, 56.10, 57.30, 10...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5330095	The number of cells in each well was determined by CytoTox-1 reagent (Promega).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "number", "of", "cells", "in", "each", "well", ...
PMC7823217	3D bioprinted constructs can effectively mimic the tumor microenvironment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "3D", "bioprinted", "constructs", "can", "effectively", "mimic", "the", "tumor", "microenvironment", "." ...
PMC6461034	INKA score ranking indicates that ABL1/BCR‐ABL (orange bars) exhibits principal kinase activity in this cell line, in line with a role as an oncogenic driver.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10940855	Cytospin slides were then processed identically to the femur slides, starting at rehydration with PBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cytospin", "slides", "were", "then", "processed", "ide...
PMC11243198	The background-subtracted luminescence of cells stimulated with SAG alone was set as 100% luminescence for calculating percent inhibition of the test compounds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11704135	The fungal strain tested was Candida albicans.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "fungal", "strain", "tested", "was", "Candida", "albicans", "." ] } ]
PMC11612794	For the CENP-C-Mis12C interaction during mitosis, the involvement of phosphoregulation of Dsn1 has been well studied.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "the", "CENP-C-Mis12C", "interaction", "dur...
PMC9429973	Fisher test was used for contingent tables.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fisher", "test", "was", "used", "for", "contingent", "tables", "." ] } ]
PMC10747139	Complex 19 exhibited moderate inhibitory effects on the metabolic and proliferation activities of the cancer cells tested compared to cisplatin (IC50 = 3.29 ± 0.88 µM and IC50 = 11.96 ± 2.71 µM, respectively, against cancerous cells).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Patients with a PMR value of <43,48 had a significantly longer PFS (for <43,48 %56, for ≥43,48 %43; p=0,027).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11258145	Along the acyl chain, it enhances ordering effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Along", "the", "acyl", "chain", ",", "it", "enhances", "ordering", "effects", "." ] } ]
PMC11765243	As shown in Figure 7B, the elongation of p110αKD-T CD4 Tfh cells induced by plate-bound anti-ICOS antibodies was significantly lower than the elongation of WT Tfh cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11786704	In conclusion, PC capsules exhibit remarkable long-term stability and antioxidant properties, which have great potential in the treatment of chronic diseases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC8316344	3TRIB2 decreased labile iron level in liver cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "3TRIB2", "decreased", "labile", "iron", "level", "in", "liver", "cancer", "cells", "." ] } ]
PMC10502403	This TCR had two amino acid replacements in the CDR2 region of the TCRβ chain to produce high affinity, which differs from the one reported by Robbins et al. G50A + A51E TCR-T cells showed tolerable toxicity and promising efficacy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10506676	To the best of our knowledge, for the first time, we showed that EBV-EBNA1 could increase the expression level of HPV-18 E6 and E7 oncogenes in HeLa cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9583612	Fourth, site-level emissions exhibit significant intraday variations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fourth", ",", "site-level", "emissions", "exhibit", "significant", "intraday", "variations", "." ] } ]
PMC10932641	Staining the cells with the crystal violet solution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Staining", "the", "cells", "with", "the", "crystal", "violet", "solution", "." ] } ]
PMC10079526	Based on our SUMO2 proteomics results and the drug mode of action, we set out to study induction of DNA damage by 5-Aza-2’ treatment and SUMOylation inhibition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11528603	Thus, the HPLC analysis results not only proved the phytochemical consistency of our S. affinis fruits in comparison to previous studies but also further consolidated the anticancer potential of S. affinis fruit extracts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10604092	Kir et al. demonstrated that PTHrP induces energy expenditure in adipose tissues and atrophy in the skeletal muscle.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Kir", "et", "al.", "demonstrated", "th...
PMC11772585	A total of 10,000 cells per sample were analyzed in the FITC channel using a BD FACS Celesta instrument.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "total", "of", "10,000", ...
PMC11727907	, and β-ACT (8H10D10 cat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ",", "and", "β-ACT", "(", "8H10D10", "cat", "." ] } ]
PMC9429973	The CCPS had 3 parameters; age, blast %, and sex (Age (years) x 0.085 + Blast (%) x 0.489 + Sex (Male) x 1.449) and 3 risk groups [Low: <6.62, Intermediate: 6.62-7.85, and High: >7.85)].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11528603	Figure 2.Morphology of HL60 cells under SA-EA treatment.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "2.Morphology", "of", "HL60", "cells", "under", "SA-EA", "treatment", "." ] } ]
PMC7642379	PCA plot showing the separation in expression pattern between samples. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PCA", "plot", "showing", "the", "separation", "in", "expression", "pattern", "between", ...
PMC9429973	However, delaying or withholding specific therapy for significant time may cause progression of a hematologic malignancy and increase the risks of tumor resistance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Methods: The analysis was conducted in 191 pts aged ≤70 y with previously untreated CLL who completed fixed-duration I+V, defined as 3 x 28d cycles of I then 12 cycles of I+V (I 420 mg/d orally; V ramp-up to 400 mg/d orally); this included pts from the FD cohort, and pts from the MRD cohort with confirmed undetectable ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11209164	The quantity of human IFN-β in the supernatant was measured using the Human IFN Beta ELISA Kit (PBL Assay Science, Piscataway, NJ, USA, cat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9503669	To begin to address this issue, a series of analogs were synthesized that replaced the diazene with one- and two-carbon linkers (Figure 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11687663	The two phytoconstituents continued to the selection for membrane permeability on the basis of their significance binding affinity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "two", "phytoconstituents", "continued...
PMC6889484	Lower blot probed with α-A3G antibody (green bands) and α-tubulin antibody (red bands).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lower", "blot", "probed", "with", "α-A...
PMC9429973	As a result cells proliferate uncontrollably, leading to a rapid cell aging.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "a", "result", "cells", "proliferate", "uncontrollably", ",", "leading...
PMC11711871	The plasma concentrations of the mineralocorticoid aldosterone and its precursor 11-deoxycorticosterone did not differ between GR and GR rats and only decreased in the wild-type rats in the afternoon (Fig. 1H, left and right panel, respectively).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9985266	HYP can be used as an important indicator of collagen metabolism and the degree of interstitial fibrosis in the lung .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HYP", "can", "be", "us...
PMC9429973	Summary/Conclusion: Taken together, our results show that a large part of genetic modifications induced by JAK2V617F mutation are p53 dependent but MPN phenotype is not, TP53 loss is insufficient to induce quick leukemic transformation in steady-state hematopoiesis in Jak2 V617F MPN despite it increases LT-HSC cell pro...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11604768	c Volcano plot of promoter responses following neurotensin 8−13 (NT) treatment in HEK293 cells co-transfected with the TRE-MPRA library and an NTSR1 expression plasmid, with or without addition of the Gαq-specific inhibitor FR900359 (FR).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9672323	Significant changes are indicated with asterisk (p < 0.05, p < 0.01, p < 0.001, **p < 0.0001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11209164	The real-time polymerase chain reaction (PCR) protocols involved the use of 40 nanograms of complementary DNA (cDNA) and the PowerUp™ SYBR™ Green Master Mix (ThermoFisher Scientific, Cat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10820104	This represents a starting point for the optimization of such prenylated alkaloids for future drug discoveries and development.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "represents", "a", "starting", ...
PMC11473750	Lastly, we assessed RNF121 CNV in other cancer types using a curated dataset of 155 non-redundant studies in cBioPortal.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lastly", ",", "we", "a...
PMC6461034	Carefully remove the supernatant and very gently loosen pellet by tapping.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Carefully", "remove", "the", "supernatant", "and", "very", "gently", "loosen", "pellet", ...
PMC11790971	These findings highlight the importance of including cells from artificial pools during training to achieve robust classification performance across the entire dataset.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "fin...
PMC9429973	immunoprofiling and proteomic analysis (LMD-LC/MS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "immunoprofiling", "and", "proteomic", "analysis", "(", "LMD-LC/MS", ")", "." ] } ]
PMC9910796	However, they require an extrinsic protein factor for proper membrane targeting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "they", "require", "an", "extrinsic", "protein", "factor", "for",...
PMC9096373	All data were expressed as mean ± standard deviation (SD).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "data", "were", "expressed", "as", "mean", "±", "standard", "deviation", ...
PMC9412887	Briefly, Gu et al. used DSPE-PEG and DSPE-PEG-cRGD to entrap PD173074 to obtain an interior core, and then utilized cRGD-PEG to load calcium phosphate (CaP) with CQ by a biomineralization method to form a shell.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11144200	After obtaining the spleen, peripheral blood, as well as tumor tissues, the tissues had been cut into tiny fragments and then homogenized.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11365427	In addition, samples from MM patients undergoing treatment were collected to serve as a validation cohort for examining the alterations in phenylalanine levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11683240	Bound PTS1 was detected using an antibody against PTS1 (left).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bound", "PTS1", "was", "detected", "using", "an", "antibody", "against", "PTS1",...
PMC10772747	These results indicate that EBE has the potential to influence the cell cycle in T47D cells, while DOX and 1,4-naphthoquinone do not have a significant effect on the cell cycle.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9019892	Drug resistance remains a major challenge in the clinical treatment of gastrointestinal stromal tumours (GISTs).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Drug", "resistance", "remains", "a", "major", ...
PMC8992508	Compound 31 was the most potent derivative on BCRP with IC50 = 0.219 M, and it can be considered rather ABCG2 selective since on P-gp it showed an IC50 value of 1.13 M. On the contrary compounds 32 and 33 can be considered as a dual P-gp/BCRP inhibitors since they showed on BCRP IC50 values of 0.285 M and 0.595 M, resp...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5874706	A novel, multi-functional nanoscale drug delivery system, based on the nanoparticle formation of functionalized amphiphilic α-cyclodextrins, is under construction and will be tested on cancer cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10530622	In cases where RNAi therapy may not be feasible or accessible, alternative agents for the treatment of PH1 have been investigated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "cases"...
PMC11638255	Whole slides were imaged using Phenochart software v1.1.0 (Akoya Biosciences, USA) via multispectral field scans.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Whole", "slides", "were", "imaged", "u...
PMC6181431	There were minor differences in the growth rate of these various A704 derivative lines, but there was no appreciable difference among them in response to rapamycin treatment for up to 6 days with and without doxycycline induction (Fig 2B and 2C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Data will be updated for the presentation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "will", "be", "updated", "for", "the", "presentation", "." ] } ]
PMC11551844	Each cell line monolayer was detached from tissue culture flasks with trypsin 0.25% EDTA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "cell", "line", "monolayer", "was", "detached", "fro...
PMC9429973	In MM-NK co-cultures in absence of daratumumab (NK cell-mediated direct cytotoxicity), the percentages of apoptotic cells in tinostamustine-pretreated vs DMSO-pretreated cells were: 83.64%±5.28 vs 61.58%±6.81 in MOLP-8 cells (p<0.05); 54.27%±5.99 vs 34.24%±7.37 for RPMI-8226 (p<0.05); and 26.15%±4 vs 12.32%±1.97 in MM....	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11757131	Abnormalities in fatty acid metabolism are often accompanied by cellular dysfunction (24).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Abnormalities", "in", "fatty", "acid", "metabolism", "are", "often", ...
PMC11519788	For in vitro ubiquitination assay, 293T cells were co-transfected with Flag-SPOP, HA-STAT3 and Myc-Ub plasmids.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "in", "vitro", "ubiq...
PMC11544771	CPX (Sigma, St. Louis, MO, USA) was prepared to 100 mM stock solution by dissolving it in 100% ethanol and stored at −20 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11082662	Importantly, this observation aligns with similar results detected in other solid and nonsolid tumors, such as prostate cancer, hepatocellular carcinoma, and acute myeloid leukemia (7,14,15).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11129910	Ductal carcinoma in situ was present in eight cases (61.53%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ductal", "carcinoma", "in", "situ", "was", "present", "in", "eight", ...
PMC9429973	During the post-induction phase, the rates of thrombotic and bleeding events were similar across all groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "During", "the", "post-induction", "phase", ",", ...
PMC9429973	In a pilot screening using syngenic reporter lines, we identified pathways that allow selective pharmacological targeting of tumor-derived F2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "a", "pilot", "sc...
PMC11473750	Furthermore, we show that patients with very high RNF121 levels and MYCN amplification together form a unique group with an exceedingly poor survival rate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11629461	Calculation of calcium peak areas revealed that NOX inhibitor DPI effect was statistically significant (Figure 3H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Calculation", "of", "calcium", "peak", ...
PMC8658661	Thus, at the proteomic level, HepG2 cells retain and multiply changes in systems associated with the metabolism of endogenous and exogenous substances compared with normal hepatocytes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11768927	Several VSV-based phase I/II clinical trials show promise; however, addressing resistance and developing novel strategies to enhance therapeutic efficacy are essential for realizing the full potential of VSV oncolytic virotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11791264	PTMs of the human LC3 isoforms (LC3A, LC3B, and LC3C) are essential for the regulation of autophagy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PTMs", "of", "the...
PMC11721277	This is apparently due to the presence of residual amounts of oxygen in the reaction mixture.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "apparently", "due", "to", "the", "...
PMC10222971	The starting materials, juglone (found in leaves, roots, husks, and barks of several species of walnut trees) and lawsone (isolated from the leaves and shoots of henna, Lawsonia inermis L.) have shown cytotoxicity against a wide range of human cancer cell lines .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5386478	Furthermore, we assessed the transamidating activity in all conditions, by incorporation of the competitive amine substrate BAP into proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", ...
PMC11794847	The antibodies were assigned into two panels: Panel I consisted HVEM (SantaCruz#sc365971,1:500), CD8 (Biolegend#100,714,1:3000), CD163 (Proteintech#16,646,1:1000), PD-L1 (Proteintech #66,248, 1:3000), CK (Abcam#ab217916, 1:5); Panel II included HVEM (SantaCruz#sc365971, 1:500), CD4 (Biolegend#317,410, 1:3000), CK (Abca...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721587	After depletion of endogenous Fu by dsRNA, these cell lines were treated with Hh-conditioned medium.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "depletion", "of", "endogenous", "Fu", "by", ...
PMC8097906	were selected for further testing Screening of selected compounds for migrastatic effects on RH-30 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "were", "selected", "for", "further", "testing", "Screeni...
PMC9428827	CD8MP and Treg number from spleens of MB16-bearing mice. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CD8MP", "and", "Treg", "number", "from", "spleens", "of", "MB16-bearing", "mice", ".", "("...
PMC11545737	Urease protein is composed of six UreA subunits and six UreB subunits with two coordinated nickel ions into each UreB .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Urease", "protein", "is", ...
PMC11791264	The membranes were then incubated with the primary antibodies: SETD7 (1:2000), LC3B (1:1000), MYC (1:1000), P62 (1:1000), E-cadherin (1:1000), Snail (1:1000), N-cadherin (1:1000), Vimentin (1:1000), Tubulin (1:10,000), GAPDH (1:1000), or Histone H3 (1:1000).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11013014	M.p.	[ { "tags": [ "O", "O" ], "tokens": [ "M.p", "." ] } ]
PMC11699042	gghalves package version 0.1.4, ggdist package version 3.2.1 and PupillometryR package version 0.0.4; for circle plots, circlize package version 0.4.15; and for PCA and volcano plots, ggplot2 package version 3.4.1 (ref. ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10988555	After that time, the medium was replaced by a medium with 10× IC50 concentrations of complexes 2–4, 0.1% (v/v) DMSO as vehicle control or 0.05% (v/v) H2O2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11063646	The A-431 cells (2 x 10 cells/2 ml) were cultured and incubated for 24 h after treatment with reference drug (camptothecin), andrographolide, and optimized emulgel ANG 12 at their IC50 concentration.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10988808	N = 6.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "N", "=", "6", "." ] } ]
PMC11365427	Cell viability in NCI-H929 and RPMI-8226 cells after 48 h of phenylalanine deprivation with siATF3 transfection. (	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "viability", "in", "NCI-H929",...
PMC11488203	In contrast, little if any signals were detectable for the expression of SDF-1 while GAPDH protein levels represented the control (Fig. 6B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC10914904

Some svtRNAs can be loaded into AGO2, regulating posttranscriptional gene silencing The human vault RNAs biogenesis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "svtRNAs", "can", "be", "loaded", "i...

PMC11541241

Various Arabidopsis mutants were impaired in TOR signalling, and plants treated with TOR inhibitor PP242 exhibited enhanced resistance to F. graminearum infection.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Various...

PMC11670407

Then 195 μL of Annexin V-FITC conjugate was added and mixed, and 5 μL of Annexin V-FITC and 10 μL of PI staining solution was added and gently mixed.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11621493

Tissues were analyzed in 2–4 biological replicates. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tissues", "were", "analyzed", "in", "2–4", "biological", "replicates", ".", "(" ] } ]

PMC10831439

For the second and third stimulations, a more concise effect of the PD-L1/2 expression on cytotoxicity could be observed compared with the first round (figure 3E).

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PMC2196094

To determine mRNA frequencies for the various proteases expressed by normal tissue MCs, an unamplified peritoneal MC cDNA library was screened with a panel of monospecific cDNA probes.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7709199

The model was refined by ten cycles of rigid-body refinement followed by iterative cycles of restrained refinement and manual model corrections.

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PMC11451940

These cellular effects resemble the effect of zinc on esophageal squamous cancer cell line EC109, leading to the induction of autophagy and apoptosis by the upregulation of wild-type p53-induced gene 1 (WIG-1), a kind of zinc finger protein, which can further be altering the expression of Bax, p21 (WAF), and cyclin D1 ...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11244823

After washing the membrane with PBS-T for 10 minutes, it was incubated overnight at 4°C with anti-V5 antibody (1:5’000; Invitrogen).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11185260

Although up to 20% of human cancers contain a loss-of-function mutation in the SWI/SNF complex, its role in tumor suppression remains understudied.10 It was only recent that several studies have revealed that SMARCB1 is a tumor suppressor with its loss required for rhabdoid tumorigenesis.3,11 The precise mechanism thro...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11759543

The combination effect of doxorubicin and vorinostat after 24 h treatment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "combination", "effect", "of", "doxorubicin", "and", "vorinostat", "after", "24", ...

PMC8973085

Yellow solid (87%); mp 220–222 °C (EtOH); IR (KBr, v, cm): 3259 (NH), 3235 (NH), 2221 (CN), 1676 (C=O), 1650 (C=O); H NMR (DMSO-d6): δ 2.43 (s, 3H, CH3), 2.66 (s, 3H, CH3), 3.63(s, 3H, OCH3), 3.71 (s, 3H, OCH3), 7.12–7.76 (m, 11H, CH-Ar), 9.51 (bs, 1H, NH), 10.62 (bs, 1H, NH); C NMR (DMSO-d6): δ 20.80, 56.10, 57.30, 10...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC5330095

The number of cells in each well was determined by CytoTox-1 reagent (Promega).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "number", "of", "cells", "in", "each", "well", ...

PMC7823217

3D bioprinted constructs can effectively mimic the tumor microenvironment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "3D", "bioprinted", "constructs", "can", "effectively", "mimic", "the", "tumor", "microenvironment", "." ...

PMC6461034

INKA score ranking indicates that ABL1/BCR‐ABL (orange bars) exhibits principal kinase activity in this cell line, in line with a role as an oncogenic driver.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10940855

Cytospin slides were then processed identically to the femur slides, starting at rehydration with PBS.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cytospin", "slides", "were", "then", "processed", "ide...

PMC11243198

The background-subtracted luminescence of cells stimulated with SAG alone was set as 100% luminescence for calculating percent inhibition of the test compounds.

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PMC11704135

The fungal strain tested was Candida albicans.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "fungal", "strain", "tested", "was", "Candida", "albicans", "." ] } ]

PMC11612794

For the CENP-C-Mis12C interaction during mitosis, the involvement of phosphoregulation of Dsn1 has been well studied.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "the", "CENP-C-Mis12C", "interaction", "dur...

PMC9429973

Fisher test was used for contingent tables.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fisher", "test", "was", "used", "for", "contingent", "tables", "." ] } ]

PMC10747139

Complex 19 exhibited moderate inhibitory effects on the metabolic and proliferation activities of the cancer cells tested compared to cisplatin (IC50 = 3.29 ± 0.88 µM and IC50 = 11.96 ± 2.71 µM, respectively, against cancerous cells).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Patients with a PMR value of <43,48 had a significantly longer PFS (for <43,48 %56, for ≥43,48 %43; p=0,027).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11258145

Along the acyl chain, it enhances ordering effects.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Along", "the", "acyl", "chain", ",", "it", "enhances", "ordering", "effects", "." ] } ]

PMC11765243

As shown in Figure 7B, the elongation of p110αKD-T CD4 Tfh cells induced by plate-bound anti-ICOS antibodies was significantly lower than the elongation of WT Tfh cells.

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PMC11786704

In conclusion, PC capsules exhibit remarkable long-term stability and antioxidant properties, which have great potential in the treatment of chronic diseases.

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PMC8316344

3TRIB2 decreased labile iron level in liver cancer cells.

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PMC10502403

This TCR had two amino acid replacements in the CDR2 region of the TCRβ chain to produce high affinity, which differs from the one reported by Robbins et al. G50A + A51E TCR-T cells showed tolerable toxicity and promising efficacy.

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PMC10506676

To the best of our knowledge, for the first time, we showed that EBV-EBNA1 could increase the expression level of HPV-18 E6 and E7 oncogenes in HeLa cell line.

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PMC9583612

Fourth, site-level emissions exhibit significant intraday variations.

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PMC10932641

Staining the cells with the crystal violet solution.

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PMC10079526

Based on our SUMO2 proteomics results and the drug mode of action, we set out to study induction of DNA damage by 5-Aza-2’ treatment and SUMOylation inhibition.

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PMC11528603

Thus, the HPLC analysis results not only proved the phytochemical consistency of our S. affinis fruits in comparison to previous studies but also further consolidated the anticancer potential of S. affinis fruit extracts.

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PMC10604092

Kir et al. demonstrated that PTHrP induces energy expenditure in adipose tissues and atrophy in the skeletal muscle.

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PMC11772585

A total of 10,000 cells per sample were analyzed in the FITC channel using a BD FACS Celesta instrument.

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PMC11727907

, and β-ACT (8H10D10 cat.

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PMC9429973

The CCPS had 3 parameters; age, blast %, and sex (Age (years) x 0.085 + Blast (%) x 0.489 + Sex (Male) x 1.449) and 3 risk groups [Low: <6.62, Intermediate: 6.62-7.85, and High: >7.85)].

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PMC11528603

Figure 2.Morphology of HL60 cells under SA-EA treatment.

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PMC7642379

PCA plot showing the separation in expression pattern between samples. (

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PMC9429973

However, delaying or withholding specific therapy for significant time may cause progression of a hematologic malignancy and increase the risks of tumor resistance.

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PMC9429973

Methods: The analysis was conducted in 191 pts aged ≤70 y with previously untreated CLL who completed fixed-duration I+V, defined as 3 x 28d cycles of I then 12 cycles of I+V (I 420 mg/d orally; V ramp-up to 400 mg/d orally); this included pts from the FD cohort, and pts from the MRD cohort with confirmed undetectable ...

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PMC11209164

The quantity of human IFN-β in the supernatant was measured using the Human IFN Beta ELISA Kit (PBL Assay Science, Piscataway, NJ, USA, cat.

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PMC9503669

To begin to address this issue, a series of analogs were synthesized that replaced the diazene with one- and two-carbon linkers (Figure 2).

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PMC11687663

The two phytoconstituents continued to the selection for membrane permeability on the basis of their significance binding affinity.

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PMC6889484

Lower blot probed with α-A3G antibody (green bands) and α-tubulin antibody (red bands).

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PMC9429973

As a result cells proliferate uncontrollably, leading to a rapid cell aging.

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PMC11711871

The plasma concentrations of the mineralocorticoid aldosterone and its precursor 11-deoxycorticosterone did not differ between GR and GR rats and only decreased in the wild-type rats in the afternoon (Fig. 1H, left and right panel, respectively).

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PMC9985266

HYP can be used as an important indicator of collagen metabolism and the degree of interstitial fibrosis in the lung .

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PMC9429973

Summary/Conclusion: Taken together, our results show that a large part of genetic modifications induced by JAK2V617F mutation are p53 dependent but MPN phenotype is not, TP53 loss is insufficient to induce quick leukemic transformation in steady-state hematopoiesis in Jak2 V617F MPN despite it increases LT-HSC cell pro...

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PMC11604768

c Volcano plot of promoter responses following neurotensin 8−13 (NT) treatment in HEK293 cells co-transfected with the TRE-MPRA library and an NTSR1 expression plasmid, with or without addition of the Gαq-specific inhibitor FR900359 (FR).

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PMC9672323

Significant changes are indicated with asterisk (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001).

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PMC11209164

The real-time polymerase chain reaction (PCR) protocols involved the use of 40 nanograms of complementary DNA (cDNA) and the PowerUp™ SYBR™ Green Master Mix (ThermoFisher Scientific, Cat.

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PMC10820104

This represents a starting point for the optimization of such prenylated alkaloids for future drug discoveries and development.

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PMC11473750

Lastly, we assessed RNF121 CNV in other cancer types using a curated dataset of 155 non-redundant studies in cBioPortal.

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PMC6461034

Carefully remove the supernatant and very gently loosen pellet by tapping.

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PMC11790971

These findings highlight the importance of including cells from artificial pools during training to achieve robust classification performance across the entire dataset.

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PMC9429973

immunoprofiling and proteomic analysis (LMD-LC/MS).

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PMC9910796

However, they require an extrinsic protein factor for proper membrane targeting.

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PMC9096373

All data were expressed as mean ± standard deviation (SD).

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PMC9412887

Briefly, Gu et al. used DSPE-PEG and DSPE-PEG-cRGD to entrap PD173074 to obtain an interior core, and then utilized cRGD-PEG to load calcium phosphate (CaP) with CQ by a biomineralization method to form a shell.

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PMC11144200

After obtaining the spleen, peripheral blood, as well as tumor tissues, the tissues had been cut into tiny fragments and then homogenized.

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PMC11365427

In addition, samples from MM patients undergoing treatment were collected to serve as a validation cohort for examining the alterations in phenylalanine levels.

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PMC11683240

Bound PTS1 was detected using an antibody against PTS1 (left).

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PMC10772747

These results indicate that EBE has the potential to influence the cell cycle in T47D cells, while DOX and 1,4-naphthoquinone do not have a significant effect on the cell cycle.

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PMC9019892

Drug resistance remains a major challenge in the clinical treatment of gastrointestinal stromal tumours (GISTs).

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PMC8992508

Compound 31 was the most potent derivative on BCRP with IC50 = 0.219 M, and it can be considered rather ABCG2 selective since on P-gp it showed an IC50 value of 1.13 M. On the contrary compounds 32 and 33 can be considered as a dual P-gp/BCRP inhibitors since they showed on BCRP IC50 values of 0.285 M and 0.595 M, resp...

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PMC5874706

A novel, multi-functional nanoscale drug delivery system, based on the nanoparticle formation of functionalized amphiphilic α-cyclodextrins, is under construction and will be tested on cancer cell lines.

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PMC10530622

In cases where RNAi therapy may not be feasible or accessible, alternative agents for the treatment of PH1 have been investigated.

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PMC11638255

Whole slides were imaged using Phenochart software v1.1.0 (Akoya Biosciences, USA) via multispectral field scans.

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PMC6181431

There were minor differences in the growth rate of these various A704 derivative lines, but there was no appreciable difference among them in response to rapamycin treatment for up to 6 days with and without doxycycline induction (Fig 2B and 2C).

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PMC9429973

Data will be updated for the presentation.

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PMC11551844

Each cell line monolayer was detached from tissue culture flasks with trypsin 0.25% EDTA.

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PMC9429973

In MM-NK co-cultures in absence of daratumumab (NK cell-mediated direct cytotoxicity), the percentages of apoptotic cells in tinostamustine-pretreated vs DMSO-pretreated cells were: 83.64%±5.28 vs 61.58%±6.81 in MOLP-8 cells (p<0.05); 54.27%±5.99 vs 34.24%±7.37 for RPMI-8226 (p<0.05); and 26.15%±4 vs 12.32%±1.97 in MM....

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PMC11757131

Abnormalities in fatty acid metabolism are often accompanied by cellular dysfunction (24).

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PMC11519788

For in vitro ubiquitination assay, 293T cells were co-transfected with Flag-SPOP, HA-STAT3 and Myc-Ub plasmids.

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PMC11544771

CPX (Sigma, St. Louis, MO, USA) was prepared to 100 mM stock solution by dissolving it in 100% ethanol and stored at −20 °C.

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PMC11082662

Importantly, this observation aligns with similar results detected in other solid and nonsolid tumors, such as prostate cancer, hepatocellular carcinoma, and acute myeloid leukemia (7,14,15).

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PMC11129910

Ductal carcinoma in situ was present in eight cases (61.53%).

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PMC9429973

During the post-induction phase, the rates of thrombotic and bleeding events were similar across all groups.

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PMC9429973

In a pilot screening using syngenic reporter lines, we identified pathways that allow selective pharmacological targeting of tumor-derived F2.

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PMC11473750

Furthermore, we show that patients with very high RNF121 levels and MYCN amplification together form a unique group with an exceedingly poor survival rate.

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PMC11629461

Calculation of calcium peak areas revealed that NOX inhibitor DPI effect was statistically significant (Figure 3H).

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PMC8658661

Thus, at the proteomic level, HepG2 cells retain and multiply changes in systems associated with the metabolism of endogenous and exogenous substances compared with normal hepatocytes.

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PMC11768927

Several VSV-based phase I/II clinical trials show promise; however, addressing resistance and developing novel strategies to enhance therapeutic efficacy are essential for realizing the full potential of VSV oncolytic virotherapy.

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PMC11791264

PTMs of the human LC3 isoforms (LC3A, LC3B, and LC3C) are essential for the regulation of autophagy.

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PMC11721277

This is apparently due to the presence of residual amounts of oxygen in the reaction mixture.

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PMC10222971

The starting materials, juglone (found in leaves, roots, husks, and barks of several species of walnut trees) and lawsone (isolated from the leaves and shoots of henna, Lawsonia inermis L.) have shown cytotoxicity against a wide range of human cancer cell lines .

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PMC5386478

Furthermore, we assessed the transamidating activity in all conditions, by incorporation of the competitive amine substrate BAP into proteins.

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PMC11794847

The antibodies were assigned into two panels: Panel I consisted HVEM (SantaCruz#sc365971,1:500), CD8 (Biolegend#100,714,1:3000), CD163 (Proteintech#16,646,1:1000), PD-L1 (Proteintech #66,248, 1:3000), CK (Abcam#ab217916, 1:5); Panel II included HVEM (SantaCruz#sc365971, 1:500), CD4 (Biolegend#317,410, 1:3000), CK (Abca...

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PMC11721587

After depletion of endogenous Fu by dsRNA, these cell lines were treated with Hh-conditioned medium.

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PMC8097906

were selected for further testing Screening of selected compounds for migrastatic effects on RH-30 cells.

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PMC9428827

CD8MP and Treg number from spleens of MB16-bearing mice. (

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PMC11545737

Urease protein is composed of six UreA subunits and six UreB subunits with two coordinated nickel ions into each UreB .

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PMC11791264

The membranes were then incubated with the primary antibodies: SETD7 (1:2000), LC3B (1:1000), MYC (1:1000), P62 (1:1000), E-cadherin (1:1000), Snail (1:1000), N-cadherin (1:1000), Vimentin (1:1000), Tubulin (1:10,000), GAPDH (1:1000), or Histone H3 (1:1000).

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PMC11013014

M.p.

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PMC11699042

gghalves package version 0.1.4, ggdist package version 3.2.1 and PupillometryR package version 0.0.4; for circle plots, circlize package version 0.4.15; and for PCA and volcano plots, ggplot2 package version 3.4.1 (ref. ).

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PMC10988555

After that time, the medium was replaced by a medium with 10× IC50 concentrations of complexes 2–4, 0.1% (v/v) DMSO as vehicle control or 0.05% (v/v) H2O2.

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PMC11063646

The A-431 cells (2 x 10 cells/2 ml) were cultured and incubated for 24 h after treatment with reference drug (camptothecin), andrographolide, and optimized emulgel ANG 12 at their IC50 concentration.

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PMC10988808

N = 6.

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PMC11365427

Cell viability in NCI-H929 and RPMI-8226 cells after 48 h of phenylalanine deprivation with siATF3 transfection. (

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PMC11488203

In contrast, little if any signals were detectable for the expression of SDF-1 while GAPDH protein levels represented the control (Fig. 6B).

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