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OTAR3088
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BioData-CellLine_annotated

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PMC9739791
Cellular uptake of the Pt(IV) prodrug 27 was studied in comparison with the free ligand 27L using FACS (fluorescence-activated cell sorting) analysis.
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PMC11726183
TOF HRMS (m/z): [M + H], calcd: 422.1506, found: 422.1506.
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PMC11591030
Studies have found that the protective effect of polysaccharides is mainly achieved through the activation of the Nrf2/Keap1 pathway, which increases the activity of antioxidant enzymes and, thereby, protects cells from oxidative damage .
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PMC11518702
IgE/FcϵR1 induction of C1ORF150 transcript expression is also diagrammed.
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PMC8469018
The cytotoxic effect of teriflunomide—an active metabolite of leflunomide—was determined using MTT assay, apoptosis detection, and cell cycle analysis.
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PMC7452526
The EDS spectrum showed an intense sharp silver peak at 3 keV, which is the characteristic absorption of metallic silver.
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PMC11352746
Neuronal cell cultures coupled with live-cell imaging systems have emerged as indispensable tools for this endeavor, offering controlled and reproducible environments for studying the effects of potential drug candidates.
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PMC2614416
The pellets are amorphous.
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PMC7762347
The authors noticed up-regulation of CDKN1A and GADD45A by CYN and its combination with MCLR after 24 h of exposure at the same concentrations as used in our study, while after short exposure of 4 h no deregulation of these two genes was noticed.
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PMC9429973
The use of these data allows us to better manage our stock of blood products and the formation of alloantibodies against minor antigens in polytransfused patients.
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PMC11609529
Sequence of the fusion junction is shown. (
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PMC9429973
In particular, lenalidomide maintenance therapy (LenM) following autologous stem cell transplant (ASCT) in younger/fitter MM patients has now become standard given the survival benefits associated with it.
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PMC11772585
ATF4 plays a crucial role in metabolic remodeling by enhancing glycolysis through direct binding to the promoter of HK2, leading to increased HK2 expression .
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PMC7192625
The results show decreased tendency of regions with both H3K27me3 and H3K36me3 to establish preferential contacts but a strong likelihood for regions with both H3K27me3 and H3K9me3 to form contacts (Figure 4D).
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PMC9352806
Lifespan was conducted from late L4 and the number was counted until all dead (Control, n = 126; BMS 100, n = 108; BMS 200, n= 138).
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PMC11734514
Visualization of protein expression was normalized with β-actin.
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PMC6160470
P-glycoprotein transporter (P-gp, ABCB1) is a major cause of MDR and therefore represents a valuable target for MDR reversal.
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PMC11705630
These different effects of GLDC on tumorigenesis amongst RCC cell lines could be attributed to extensive tumoral heterogeneity and subclonal evolutionary nature of RCC 41.
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PMC9024365
However, we observed a significant increase in the mean size of GluA2 clusters when co-localized with IF-NTD/SD4-TM compared with GluA2 alone (Figure 2H).
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PMC11673128
Unconjugated human anti-CD47 mAb (clone B6H12.2) and human IgG1 isotype control were purchased from BioXCell (Lebanon, NH, USA) and stored at 4 °C.
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PMC11697065
BisAb1 and BisAb2 expressing clones led to 30.62 % ± 2.41 and 11.45 % ± 0.29 extracellular aggregates respectively (Fig. 3C).
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PMC11792740
Upon activation, T cells rapidly proliferate and secrete large quantities of cytokines, such as tumor necrosis factor (TNF) and interferon-gamma (IFN-γ), which enhance the antitumor activity of other immune cells .
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PMC11727062
The plant is recognized for its pharmacological properties, which include heat-clearing, detoxification, anti-inflammatory, antibacterial, antioxidant, antitumor activities, and neuroprotective effects (Huang et al. 2024).
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PMC9429973
Disclosure: Project founded by a Sanofi’s grant (SGZ-2019-12810).
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PMC11122631
The collection was stored at the Department of Marine Biotechnology and Resources, National Sun Yat-sen University, and a voucher ID (CI2021) was given.
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PMC11697065
B: High (H) and low (L) antibody secreting clones for each biotherapeutic were grouped according to cell specific productivity (qP) data derived from a fed-batch culture evaluation.
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PMC11739484
This figure illustrates the miRNA-mRNA network construction analysis of MMP7, MMP11, and MMP14 genes in skin cutaneous melanoma (SKCM), conducted using the miRNet database and RT-qPCR assay.
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PMC9429973
In three patients (9%, all European) we were unable to identify the genetic cause unequivocally.
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PMC11486946
Red and black circles denote MSD values with and without EGF, respectively.
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PMC11763764
EGFR overexpression is associated with poor prognosis in ovarian cancer .
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PMC11412721
ns: nonsignificant.
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PMC11462929
Japan Society for the Promotion of Science (Grant/Award Number: JP19H03615).
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PMC8873393
These results imply that lncRNAs and mRNAs may have different mechanisms regulating their biogenesis, stability, and spatial-temporal expression patterns during DNA damage repair.
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PMC9429973
According to the WHO classification of COVID-19 severity, mild forms were registered in 4 (23.5%) cases, moderate in 8 (47.1%) and severe in 5 (29.4%) cases.
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PMC11528603
Treatment with SA-EA at IC50 value resulted in apoptotic specific morphologies, nuclear fragmentation, and caspase 3 activation in HL60 cells.
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PMC7351993
Before cultivation with C-stable isotope media, Euglena gracilis cells were grown in normal AF-6 medium for at least 3 days as preculture.
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PMC11803149
n=3 per group.
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PMC10831439
In this work, CD19-CAR-iNKT cells showed enhanced functionality in a direct comparison to CD19-CAR-T cells both in vitro and in vivo.26 Here, the authors also found a cooperative activation of CD19-CAR-iNKT cells through CD1d and the invariant TCR.
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PMC10551595
The main challenge in this regard is to discover not only beneficial compounds that may activate multiple survival pathways for healthy cells, but also toxic substances that may selectively target cancerous cells.
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PMC9429973
However, HRs for A+O versus C+OCLL11 (HR=0.39 [95% CI=0.18-0.84], p=0.02) and for A versus C+OCLL11 (HR=0.48 [95% CI=0.24-0.99], p<0.05) were statistically significant.
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PMC11770746
National University of Singapore–Protocol Number: R2021-0034 .
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PMC11786156
The detailed mechanism underlying invasion inhibition has not yet been fully elucidated.
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PMC10578720
Notably, two-thirds of TCA cycle enzymes are reportedly acetylated in response to pathogen challenge, suggesting that acetylation may play a direct role in metabolic regulation by affecting the function of modified TCA cycle enzymes and thus participate in initiating innate immune responses.
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PMC11306331
p > 0.05; *: p < 0.05, **: p < 0.01, ***: p < 0.001 G, H Quantification of dissolution efficiency from microscopy data by calculating the change in the coefficient of variation and enrichment.
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PMC9429973
Cell viability in response to 10 uM library concentration upon 72h was assessed by Cell-Titer Glo and evaluated against the wild-type counterparts.
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PMC10812665
Seven compounds of the NTP library met this criterion .
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PMC11560255
The cells were dipped in ethanol, dried, and mounted.
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PMC11802855
All confidence intervals (CIs) were calculated at a 95% level. *
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PMC11622247
Microporation was used to deliver the probes into “difficult-to- transfect” T cells.
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PMC10253973
In addition, these compounds were cytotoxic towards breast cancer cells (MDA-MB-231, MCF-7), cervical cancer cells (HeLa) and promyelocytic leukemia cells (HL60) and are less toxic towards lung fibroblast cells (MRC-5) compared to 1.
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PMC9429973
Ltd., Hyderabad, India; Department of Hematology and Oncology, Santa Casa de São Paulo School of Medicine, São Paulo, Brazil Background: Vaso-occlusive crises (VOCs) are the hallmark of SCD and can lead to serious complications and organ damage.
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PMC11139449
Both CHO-K1 and CHO-KO cells were transfected with the pLEX-JRed vector in triplicate.
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PMC11727062
Not only that, dihydroartemisinin, a derivative of artemisinin, has demonstrated anti-melanoma properties.
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PMC9895440
The plate was then recorded immediately in a BioTech H1 fluorescence reader at 490 nm excitation and 525 nm absorbance for 30 min.
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PMC9429973
Methods: Eligible pts had received ≥3 prior lines of treatment.
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PMC9429973
Hypermethylation of RRAD in MM leads to epigenetic inactivation, which reduces the expression of RRAD and reduces MM Apoptosis of cells loses its anti-tumor effect, which is a new molecular mechanism for the occurrence and development of MM.
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PMC9429973
To the same direction, clustering of the usage of TRAV-TRAJ further confirmed this finding (Figure 1D).
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PMC11695546
Then, the microplate was cultivated in MBC at the 75, 50, and 25% sub-lethal levels that were already established.
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PMC9429973
The mechanism involved in the proliferation and migration of DLBCL cells by promoting the production of ROS.
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PMC11155445
Compound (34F29) exhibited outstanding antibacterial activity against Xanthomonas oryzae pv.
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PMC11739696
This dysregulation was demonstrated by the statistically significant decreases in the expression level of apoptotic p53 (p < 0.01) and mitochondrial ND3 (p < 0.001) genes along with the significant increase (p < 0.001) in the expression level of anti-apoptotic Bcl2 gene observed in A-375 cells treated with Co3O4NPs com...
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PMC10605143
NOTCH binding to the HSF1 promoter was demonstrated in samples from patients with acute T-cell lymphoblastic leukemia, resulting in increased expression of HSF1 and its downstream effectors with subsequent activation of the cellular stress response machinery .
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PMC10538569
Schematic diagram of lentiviral transfer vector pRRL-GPI-HA-scFv X5 or AB65-2A-GFP.
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PMC6267596
It is surmised that these types of reductive cell divisions occur in vivo within tumors exposed to polyploidy inducing drugs and is an escape mechanism leading to disease relapse.
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PMC9429973
Out of 18, 6(33%) had known comorbids, 5(28%) had hepatomegaly, and 11(61%) had splenomegaly.
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PMC7917457
Flow cytometric analyses were performed using a BD Accuri 6C Plus Flow Cytometer (BD Biosciences).
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PMC11306331
We also tested Glutathione S-transferase (GST), an affinity tag commonly used in protein purification that has also been suggested to promote solubility, and mCherry, which was previously suggested to inhibit protein phase separation.
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PMC11397654
The activity of 71 and its doxorubicin complex was analysed using M-HeLa cells and human hepatocyte cells (Chang liver cell line).
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PMC2777936
Thermal cycling was performed using an Applied Biosystems 7500 Fast Real Time PCR System and real-time amplification data were obtained using ABI 7500 Fast System SDS software.
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PMC10968586
In human osteosarcoma MG-63 cell line, 20 μg/mL (≈37 μM) OLE had an additive effect on anthracycline Adriamycin-induced reduction in cell viability, with a mechanism that did not alter the G2/M phase blockade elicited by Adriamycin .
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PMC7612475
C, Quantification of three independent experiments described above (≥200 cells were scored/experiment).
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PMC11740907
The arrows (white color) indicate apoptotic bodies in HeLa cells.
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PMC10858941
Conversely, in the hypoxic zone of the NNC-treated chips of both cell lines, there seemed to be no accumulation of p62 protein, which could indicate a lower effect of the drug in blocking autophagic flux under hypoxia.
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PMC11188874
The proteasome multicatalytic protein-hydrolyzing 20S CP consists of 28 subunits assembled as four stacked, heptameric rings.
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PMC11594641
A higher protein content of sEVs secreted by dKO A375 cells, compared to WT sEVs, was detected using BCA and silver staining assays (Figure 8D,E).
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PMC11413393
However, no decrease in cell proliferation was noted in our screen for the compounds MS049 and SGC707 that specifically target PRMT4 (CARM1)/PRMT6 and PRMT8, respectively.
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PMC11783017
D, E) Representative fluorescence images and fluorescence intensity analysis of ROS levels in tumor. (
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PMC6835428
In our opinion, the use of mathematical modeling in the siRNA field became possible after the publication of the seminal work of Bartlett and Davis .
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PMC10213199
Clustered sub-networks in the co-expression network.
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PMC11587541
However, studies have revealed the disruption of neuronal differentiation and neurogenesis due to telomere shortening induces oxidative stress, DNA damage, and impaired DNA repair mechanisms may all play a role in accelerating telomere shortening in SMA patients and can contribute to motor neuron degeneration as shown ...
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PMC11055443
Group I were Caco-2 cells that received no treatment.
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PMC11679892
Pelargonium sidoides (P. sidoides) root extract has been used in traditional treatment methods for a long time and has been found to be effective in modern medicine, especially in the treatment of upper respiratory tract infections .
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PMC11209164
In addition to qPCR analyses, an enzyme-linked immunosorbent assay (ELISA) was conducted to quantify IFN-β in the supernatant of cell cultures.
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PMC6337547
The compounds salvianin and monardalins are obtained from Salvia coccinea L. and Salvia splendens Ker-Gawl.,
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PMC11790971
Each data point represents the result of one cross-validation fold.
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PMC11680578
Our findings indicate that the ratio of red to green fluorescence cells decreases in cells treated with PTX and RGZ.
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PMC11352666
MRX-2843 is a new drug that targets MERTK and is currently in clinical trials.
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PMC9429973
2019;14(1); Saaka, Ghana Med J. 2012;46(4):225-233), there have been no studies in adults with chronic anemic in the developed world.
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PMC10529414
Cat. #
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PMC11638288
c NKCE targets two activating receptors on NK cells, NKp46, and CD16, as well as tumor antigens on cancer cells to promote ADCC and control tumor growth through activating receptor CD16 expressed on NK cells The molecular mechanism and function of NKp46 in antitumor activity.
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PMC9919300
The cells were cultured in Eagle’s Minimum Essential Medium (EMEM) (ATCC) supplemented with 10% (v/v) heat-inactivated FBS, 100 U/mL penicillin, 50 µg/mL streptomycin, and 2 mM L-glutamine.
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PMC11770199
We found that apoptosis-related pathway was enriched (Fig. S2C).
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PMC9014716
(Venn diagram): The results of the intersection of the X and Y data set: 5 miRNAs possibly targeting ABCB1 gene were remained (https://bioinfogp.cnb.csic.es/tools/venny/index.html). (
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PMC11297139
Administering BD98 to embryonic stem cells and T cells can effectively simulate the impact of ARID1A depletion, causing a reduction in the ARID1A-oriented transcriptional program.
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PMC11786704
The H&E staining images of the skin wounds after 14 days were shown in Fig. 4E.
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PMC11190062
For comparison of more than two groups, one-way or two-way ANOVA followed by Sidak’s multiple comparisons test was used as indicated.
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PMC11572213
Furthermore, a study of monocytic U937 cells showed that it activates AMPK and adaptive mechanisms to overcome glutamine deficiency in response to glutamine starvation.
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PMC11264242
Interestingly, wild-type SS18 protein is a transcriptional coactivator, while SSX acts as a mediator of repression (Brett et al., 1997; Thaete et al., 1999; dos Santos et al., 2001).
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PMC6487404
Our suggestion is more confirmed by the ketoconazole data in everted sacs.
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PMC9927933
In this study, we showed that UBE2C is an oncogenic protein in the lung, supported by association studies in human lung tumor tissues, in vitro cell culture gain- or loss-of-function studies using lung cancer cell lines harboring Kras mutations, and an in vivo conditional KO study using a Kras mouse lung tumorigenesis ...
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