Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC11583690
DTX was loaded onto nanoparticles using the adsorption equilibrium method .
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PMC9429973
Adverse events included CRS (Lee 2014 criteria for comparison with ZUMA-2), ICANS (ASTCT consensus grade), prolonged cytopenia, infection and subsequent neoplasm.
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PMC9429973
The amount of mutations per individual increased with age.
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PMC8750422
Statistical analyses were performed with a Student’s t-test and the log-rank test. *
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PMC7039683
We re-analyzed our published meta-analysis of two GWASs for orofacial clefting (Leslie et al., 2017).The details of each contributing GWAS have been extensively described.
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PMC10329074
Subsequently, cell proliferation, migration, invasion, and apoptosis detection experiments were conducted, revealing that overexpressed YBX3 effectively promoted the proliferation (P < 0.01), clone formation ability (P < 0.01), cell cycle progression (P < 0.01), migration (P < 0.05), and invasion (P < 0.001) of the ACH...
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PMC9429973
One pt in Tmt B experienced a dose-limiting toxicity of grade 4 neutropenia for >14 days.
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PMC10174970
The pathway-similarity profiles of cell lines to human tumors were compared based on correlation coefficients of all 134 pathways using Mann-Whitney U-test.
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PMC11451940
for C30H26CuN4O7 (Mr = 618.1): C 58.3, H 4.2, N 9.1.
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PMC11490153
RNA extraction and cDNA synthesis kits were obtained from Yekta Tajhiz Azma Company (Tehran, Iran).
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PMC10454535
The Oxidative Stress Defense Western Blot Cocktail (Abcam), which includes catalase, smooth muscle actin, SOD1, and thioredoxin antibodies, was diluted 1:250.
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PMC11481779
It is also done in our work to propagate information through the whole heatmap.
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PMC11551844
HT-29 (ATCC HTB-38) cells were plated at a density of 3.0 × 10 cells/25 cm flask and cultured in 35 mm 6-well plates for 48 hours (h) prior to treatment.
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PMC8873393
D The average relative transcript levels within each cluster presented in Fig. 5B are shown, with the log2 expression values on the y axis and time on the x axis.
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PMC2614415
VE-465 has been shown to have some activity against mutant BCR-ABL kinase in mice at 75 mg/kg and to induce apoptosis in multiple myeloma cells at 100–500 nM .
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PMC9261184
In the “gas mode”, boil-off gas (BOG) from LNG cargo tanks is heated and injected into the engine at low pressure, along with a small amount of pilot diesel fuel (0.5–1.5% of the total energy consumption) to facilitate ignition.
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PMC10055960
A substantial increase in efficacy across all cell lines when compared to the precursor ligand 1 was also observed, thereby suggesting a strong positive influence of the bimetallic center in this case.
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PMC9429973
Immunosuppression (IS) consisted of cyclosporine A, mycophenolate mofetil and antithymocyte globuline (MUD and MMUD only) or post transplantation cyclophosphamide, tacrolimus and MMF (haplo-donors only).
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PMC11755519
Effects of extracellular vesicles secreted by bladder cancer cells on normal cells.
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PMC11770130
The lysates were then separated by SDS-PAGE and transferred to Immobilon 0.45 mm membranes (Cat# IPVH00010, Millipore).
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PMC9386809
268 mg (94% yield); yellow solid mp 179–181 °C; H NMR (400 MHz, DMSO-d6): δ 1.09 (t, 3H, J = 7.1 Hz, CH3), 2.26 (s, 3H, CH3), 3.96–4.01 (m, 2H, CH2), 5.22 (d, 1H, J = 3.0 Hz, CH), 7.43 (d, 2H, J = 8.3 Hz, Ar), 7.83 (d, 2H, J = 8.4 Hz, Ar), 7.86 (br s, 1H, NH), 9.33 (s, 1H, NH); C NMR (100 MHz, DMSO-d6): δ 14.5 (CH3), 1...
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PMC11489351
Interestingly, our RNA-Seq data reveal that the expression of both reversible enzymes (such as glucose-6-phosphate isomerase and triosephosphate isomerase) and irreversible enzymes (such as hexokinase and pyruvate kinase) are affected by pHi (Fig. 5A).Figure 5Transcription of glycolytic pathway enzymes and regulators o...
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PMC10421378
The composition of the samples (Figure 6), which exhibited higher contents of dead, mid-active I, and mid-active II cells than pre adhesion, showed that these subpopulations were unable to adhere, and were left suspended in the medium, which was analyzed for its contents.
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PMC11794588
The compound’s ability to halt cell cycle progression and induce apoptosis makes it a potential anticancer agent.
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PMC11615218
c The metabolic phenotypes and memory status of T cells are interconnected.
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PMC9429973
Among the few relapsed cases, we observed a rather high incidence of CNS involvements.
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PMC8427838
TMIGD1 binds to the ERM family proteins moesin and ezrin, and an evolutionarily conserved RRKK motif on the carboxyl terminus of TMIGD1 mediates the interaction of TMIGD1 with the N-terminal ERM domains of moesin and ezrin.
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PMC11012012
Targeting SLAMF6/CD352 can be suggested as a potential therapeutic strategy for CLL .
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PMC11190062
p-Values were calculated using one-way ANOVA; *p ≤ 0.05, ***p ≤ 0.001. (
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PMC11772585
To further elucidate the potential involvement of METTL1 in tumor progression, we evaluated its protein and mRNA level along with m7G methylation levels in the cSCC cell lines (HSC-1 and A431) in comparison with control HaCaT keratinocytes.
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PMC11786156
The graph and the table show the mean and standard deviation of the OD at 570 nm. †, ‡:
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PMC7887261
The fourth and fifth variants are two pathogenic, truncating deletions ─ p.I24M fs*22del (rs752672077) in MPZL2 (Myelin protein zero-like protein 2, or Epithelial v-like antigen 1 [EVA1]; OMIM 604873, UniProt O60487), and p.Q334V fs*3del (rs563947699) in MLNR (Motilin receptor; OMIM 602885, UniProt O43193) ─ with effec...
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PMC11269933
Recombinant Flag-CgPK plasmid and its site-mutated variants, along with additional upstream plasmids such as Myc-CgErk plasmid, were co-transfected into HEK293T cells as above.
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PMC11676670
Flow cytometry analysis further supports the epithelial nature of the OVAR79 cell line, demonstrating a higher expression of epithelial markers such as CD324 (E-cadherin), CA125, and EpCAM, compared to the mesenchymal markers CD325 (N-cadherin) and Vimentin (Figure 4B).
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PMC8903741
At that point, we inserted no reporter gene with the vectors, did not label the IgG using GFP, and expressed IgG chains separately to impede a low yield of antibody production, as well as to decrease experimental steps for truncating the expressed reporter molecule from the antibody.
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PMC6450504
The cytotoxicity evaluation of HeLa cells with the different bPEI-coating showed enhanced liposomal PTX cytotoxicity up to the levels that matched the free drug (Figure 4(a)).
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PMC10729469
The development of optimal neuroprotective immune responses, especially in aged patients, who possess weakened or compromised immune systems remains challenging .
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PMC11247842
Then, the clean reads were mapped to the cattle reference genome ARS-UCD1.2 using bwa mem with parameter ‘M’ to mark shorter split hits as secondary.
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PMC11697189
Immune checkpoint genes expression differences were analyzed based on prognostic signatures.
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PMC11422497
Randomization of animals into experimental groups was carried out for each study, minimizing potential bias.
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PMC9429973
Kit treated WB activates the adaptive and innate immune system after MLC (Tcell proliferation, antitumor-supportive Tcells (TCRgd,Tb7), memory cells (Tcm,Tb7cm) and downregulates immunosuppressive Tcells (Treg4 and 8).
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PMC11673902
Going forward, we anticipate that the measurement of single-cell mechanical phenotypes will become more accurate and comprehensive as the technology continues to improve in terms of throughput, degree of automation, and integration.
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PMC5716223
One unit of enzymatic activity was defined as the amount of enzyme that forms 1 µmol of product per minute per mg of tested protein.
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PMC11172027
It is shown that the selenium-containing amino acid NASeLM strongly reduces cell growth and mitochondrial activity in MTC-SK cells in comparison to Jurkat cells via an additional mechanism of action, which is not dependent on radical-induced metabolism—as measured by carbonyl protein content.
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PMC9429973
Five (38.4%) had undetectable MRD prior to proceeding to transplant.
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PMC9429973
Summary/Conclusion: Our results are much lower than the literature with a mediocre survival of these refractory forms encouraging the introduction of BB as protocol of salvage therapy and the respect of the ACSP in the good responders.
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PMC10631132
Both cell lines and both differentiation protocols showed a higher expression of the ectodermal marker Otx-2 compared to SOX1 (Fig. 3A,D,G,J).
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PMC9429973
Additionally, details of assay limit of detection (LOD), reference sequences and interpretation databases utilised were also requested.
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PMC10178190
The ability of CM, derived from tumor-activated MSC, to promote platinum chemoresistance was observed in several OC cancer cells.
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PMC11093197
A histone demethylase, KDM5A, was originally identified by screening proteins that bind to pRB mutants but are incapable of binding to E2Fs.
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PMC11657744
Cells depleted of Cep83, Cep164, and Sclt1 showed reduced anchoring of the cilium to the plasma membrane, indicating disrupted early ciliogenesis.
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PMC11422150
We have demonstrated that intravenous administration of hAMSCs improved the gait and sensory function in the chronic phase.
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PMC8414691
DOM-A was originally found to be the main subunit of the Drosophila Tip60 (dTip60) chromatin-remodeling complex whose subunits share high sequence identity and functional conservation with SRCAP and p400/Tip60 human complexes .
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PMC8073654
The essential oil from Z. cassumunar contains three major components, sabinene, terpinen-4-ol, and (E)-1-(3,4-dimethyoxyphenyl)but-1,3-diene, which exhibited antioxidant activity upon scavenging the 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) cation radical and demonstrated H2O2 scavenging activity whe...
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PMC8750422
Consistently, L-NAME treatment significantly inhibited A549 lung adenocarcinoma cell invasion by GPR87 overexpression (Figure 4f).
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PMC11673128
Although Vaccaro and Colleagues initially demonstrated that targeted therapy could prime macrophage activity in NSCLC , limited information exists regarding the effects of TKIs in different ALK+ malignancies.
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PMC11585994
Overall, our findings demonstrate that G5-sgc8-siBCL11B nanoparticles effectively deliver siBCL11B and downregulate BCL11B expression in T-ALL cells, thereby promoting apoptosis and inhibiting cell viability.
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PMC3888431
Additionally, the final transcripts can be browsed using the SAMS web-interface (https://sams.cebitec.uni-bielefeld.de/cho.html) (Figure 11), which is an extended version of the original SAMS system .
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PMC11739670
Superposition of the HLA‐A2‐CD8 co‐complex structure (PDB accession code: 1AKJ) colored as in A) and HLA‐A3 (PDB accession code: 3RL1), displayed as a blue cartoon.
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PMC11049548
A high level of glucose can induce oxidative stress and reduce oxidative phosphorylation , while a high level of pyruvate can reduce the use of glutamine as a carbon source for the Krebs cycle .
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PMC9429973
Methods: We have created a custom panel of 48 compounds covering a range of different drug classes, many of which are already used in the treatment of myeloid malignancies.
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PMC9261184
A technical summary of the voyage conditions, durations, fuel use, and emissions is given in the Supporting Information (Table S2), and the raw emissions data collected across the voyage can be found in the Supporting Information as a separate database.
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PMC9429973
While our results suggest potential merit for early detection of NHL development through immunogenetic sequencing, the current cohort size does not yet permit drawing definitive conclusions.
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PMC8777939
The mice were injected with 100 µL NpFlamma HGC ICG by i.p.
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PMC11281366
Given that HIV-1 accessory proteins, such as Vpu, have been reported to modulate the expression of miRNAs , we tested if their expression could impact miRNA-26a levels.
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PMC11218145
Fig. 2TB affects the Ca transmission from ER to mitochondria.
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PMC11537649
The underlying mechanism is that Lnc NEAT1 serves as a sponge for miR-152-3p to suppress the inhibitory effect of miR-152-3p on CDK6.
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PMC10745221
In the 143B, HCT116, and HeLa cells, many proteins with ADMA are present upon immunoblotting across a wide range of molecular weights (Fig 6).
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PMC10530622
However, when administered to PH1 patients who are dependent on dialysis, stiripentol has demonstrated limited effectiveness in lowering plasma oxalate levels.
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PMC6461034
R that is included in the INKA pipeline code.
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PMC10988555
Besides apoptosis, other types of programmed cell death, such as autophagy, which have been shown to be commonly triggered by different metal complexes.
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PMC11604768
Both Neuro-2a and MDA-MB-231 cell lines are known to harbor missense mutations in the DNA-binding region of p53 (V170L and R280K, respectively), which may explain the lack of transcription from these promoters, as p53 missense mutations have been shown to hamper utilization of response elements in human p53 target gene...
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PMC9429973
This may support recommending HSCT in DNMT3A-mutated AML, as argued for TP53- and JAK2-mutated AML.
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PMC7057940
Nested PCR is a modification of PCR that was designed to improve sensitivity and specificity.
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PMC9429973
The aim is to run a program of early and late phase clinical trials evaluating the safety and the efficacy of new agents in pediatric leukemia, eventually setting a new standard of treatment for relapsed AML.
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PMC9509578
Organic, lipid, polymer, metallic and quantum dots-based nanomaterials decorated with ligands for the co-delivery of chemotherapeutic drugs and siRNA to overcome cancer MDR in resistant cells.
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PMC11775197
PPAR is a nuclear receptor that exists in three subtypes: PPARα, PPARβ /δ, and PPARγ.
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PMC6684588
Interspecies differences in the relative involvement of these ligands could partly explain why inhibitory agents targeting myostatin alone have typically displayed greater efficacy in preclinical than clinical studies.
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PMC9429973
These patients had an excellent result with a PFS of 85.4% at 3 years, similar to the younger patient population.
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PMC11585565
The results demonstrated that the WT CNNM4 mRNA levels were not significantly changed after actinomycin D treatment over 24 h (Fig. 3b), whereas c.1474G > T and c.1475G > A CNNM4 levels decreased significantly to 51.2 ± 18.5% and 52.9 ± 2.4% after actinomycin D treatment for 4 h and were 18 ± 5.0% and 29 ± 5.4%, respec...
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PMC9429973
Grade 1 cytokine release syndrome (CRS) was found in 2 patients.
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PMC11591794
Then, the columns were placed in sterile new 1.5 mL Ependorf tubes, and 60 µL of the solution given in the kit was pipetted to the middle of the membrane in the column, and these columns were centrifuged at 12,000× g. Pure RNAs were collected in an Ependorf tube by centrifugation for 1 min.
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PMC10907726
For instance, Xie et al. found that DATS inhibited the growth of Saos-2 OS cells and upregulated calreticulin expression.
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PMC7709199
Despite several crystal-optimization attempts, the crystals of HEK293T-expressed DSCAMIg7–Ig9 yielded only poor diffraction (∼8–13 Å).
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PMC11661024
SD: standard deviation The apoptosis induction outcomes in the HeLa and HUVEC cell lines upon treatment with two postbiotics at IC50 concentrations are presented in Fig. 3.
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PMC10669966
Further studies are required to develop these drugs for clinical use.
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PMC11144200
n = 3.
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PMC9429973
Thus, 2982 (13.7%) patients had no Rx prior to diagnosis of whom 989 (33.2%) had DLBCL, 775 (26.0%) had CLL, 722 (24.2%) had MM, and 496 (16.6%) had FL.
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PMC11060216
Immunohistochemical expression of TTF-1 (A) Calu-6, (B) Calu-6/neo, (C) Calu-6/S100A6), NapsinA (D) Calu-6, (E) Calu-6/neo, (F) Calu-6/S100A6.
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PMC9429973
It included following: histologically confirmed transformation (by two consequent biopsies or morphological signs of high- and low-grade lymphomas in one biopsy sample), lymphoma history longer than 4 months, discordant bone marrow involvement (infiltration by small B-cells), paraprotein secretion, leukemic blood count...
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PMC6901583
The progression of cancer involves discrete signals of the microenvironment that influence different cells, such as macrophages.
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PMC11395280
To establish an intact monolayer, we used 24-well transwell inserts and allowed the cells to grow for 4–8 days (see Methods Section 4).
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PMC11687663
Angiopteris helferiana (A. helferiana) C. Presl is a large fleshy fern that is a member of the Marattiaceae family and can be found in moist forests in Southeast Asia, China, Nepal, India, and Sri Lanka at elevations between 900 to 1400 meters.
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PMC11489351
Raw sequences were trimmed of adapters with Trimmomatic version 0.39 (93) and assessed for quality with FastQC v 0.11.8 (Babraham Bioinformatics).
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PMC11627060
As a biological marker for apoptosis, DNA fragmentation analysis was employed biochemically to distinguish between necrotic and apoptotic cells.
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PMC11742670
Their research provides a comprehensive examination of the present status of AI’s utilization in drug repurposing and pharmaceutical development.
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PMC11252033
Membranes were visualized at the Odyssey Infrared Imaging System (LI-COR Bioscience, Lincoln, NE, USAEuroclone, Milan, Italy) and densitometric analysis was performed by Odyssey Image studio software (LI-COR Bioscience, Lincoln, NE, United States Euroclone, Milan, Italy) Quantity One software (Bio-Rad, CA, United State...
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PMC9596868
No. NP0336BOX) in Xcell Surelock Mini-Cell Electrophoresis System (ThermoFisher Scientific, Cat.
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PMC10547921
Hydrophobic molecules with good membrane penetration have a strong bystander killing effect, but this may also make the drugs easily absorbed by healthy tissues, resulting in serious systemic toxicity.
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PMC11788920
C, D, F, and G) Cy3 and Cy5 fluorescence emission intensities as a function of time for the WT (contains the PQS) and GQ-mutant (PQS is mutated) DNA construct, respectively.
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