OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC9646302	Notably, A20 is a powerful inhibitor of the NF-κB and MAPK signaling cascade, and LAPTM5 directly promotes A20 degradation by binding with it in HeLa cells in the endolysosomal system .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellL...
PMC11766309	The 3 pathways associated with the most negative correlations were the bile acid metabolism, xenobiotic metabolism, and KRAS signaling pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "3", ...
PMC9429973	D. Blickstein, M. Izak, T. Filipovich- Rimon, O. Garach- Jehoshua, N. Rahimi- Levene, E. Shinar, A. Bar- Chaim, M. Koren-Michowitz Hematology, Shamir Medical Center, Beer Yakov; Magen David Adome, National Blood Services, Ramat Gan; Hematology laboratory; Blood bank, Shamir Medical Center, Beer Yaakov; Magen David Adom...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11420784	Salmonella Typhimurium secretes effector SopF to block host cell autophagy by blocking V-ATPase–recruited ATG16L1 onto bacteria-containing vacuoles .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Salmonella", "Typhimurium", "secretes",...
PMC9429973	Biallelic mutations in CD36 are associated with platelet glycoprotein IV deficiency (PG4D), characterized by macrothrombocytopenia with variable bleeding phenotype (PubMed: 7533783; OMIM: 173510).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11656380	The macropinocytic index in three T-ALL cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "macropinocytic", "index", "in", "three", "T-ALL", "cells", "." ] } ]
PMC9532503	From day 3 onwards, cells were fed with CHO feed, glucose, galactose, U1 and U2 feeds, TE mix, and lipid mix until day 11.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7841067	Thus, AKAP4 may act as a potential therapeutic target for human thyroid cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "AKAP4", "may", "act", "as", "a", "potential", ...
PMC10996034	The present study provides novel drug resistance molecular targets and insights for their clinical application in patients with EOC with Taxol-induced multidrug resistance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11699042	Right, standard error of ED for each specific screened compound.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Right", ",", "standard", "error", "of", "ED", "for", "each", "specific", "screened", ...
PMC9920575	It should be noted that the S. edule wild varietal group extract has an IC50 of 1170 μg/mL , so the S. chinantlense extract is 600 times more effective as an antitumor agent, with similar in effectiveness in inhibiting the proliferation of the same cervical cancer line to that reported in a new cultivar of S. edule cal...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742047	Although LPC can trigger the activation of caspase 1, which is a major player in the apoptotic process, in AML LPCAT3 is implicated in cancer progression involving iron-mediated lipid oxidation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11377827	HIF-1α: control vs. USP43 sgRNA *P = 0.0024, control vs. 14-3-3 siRNA P = 0.023, control vs. USP43 sgRNA + 14-3-3 siRNA *P = 0.0186.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10366908	After three additional injections every week (1 × 10 cells/rat), a final booster injection (1 × 10 cells/rat) was performed two days before harvesting spleen cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11707832	They identified the MAN2B1 SNP (rs10411619) in Hispanic patients and the MAN1C1 SNP (rs12130495) in African Americans.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "identified", ...
PMC11286266	Additionally, ATF6α_LD has a conserved region (RTKSRR) related to the FURIN cleavage motif generally described as RX-R-X-[K/R]-R↓ (Nakayama, 1997; Figure 1—figure supplement 4E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11206251	In addition, it is generally believed that TLR4/NF-κB/MyD88 and JAK2/STAT3 are the important signaling pathways related to inflammation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "it", ...
PMC3915447	Doxorubicin and folic acid (FA) were purchased from Sigma-Aldrich Chemical Co. (St. Louis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Doxorubicin", "and", "folic", "acid", "(", "FA", ...
PMC11707577	Semi‐quantitative analysis of oligothiophene fluorescence intensity detected in confocal images.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Semi‐quantitative", "analysis", "of", "oligothiophene", "fluorescence", "intensity", "detected", "in", ...
PMC9786247	Indeed, C. burnetii shedding was linked to subclinical mastitis, with elevated levels of somatic cell counts indicative of some inflammation upon infection of the organ .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9712534	Western blot analysis of H58Y/WT and WT/WT cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Western", "blot", "analysis", "of", "H58Y/WT", "and", "WT/WT", "cells", "." ] } ]
PMC8193046	We favored this virtual screening dataset compared to other options because the identified ABCC1 inhibitors (12–15; Fig. 2) were in parallel multitarget ABCB1, ABCC1, and ABCG2 inhibitors, which possibly increased the chance to identify novel lead molecules for broad-spectrum ABCB1, ABCC1, and ABCG2 inhibition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742231	New Cell Line Test Experiment: In the tests for new cells, the drugs and cells are separated into the training, validation, and test datasets instead of the interaction pairs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11650848	Withdrawal after randomisation (n = 25) or reasons for exclusion from the intervention are indicated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Withdrawal", "after", "randomisation", "(", "n", ...
PMC9429973	ATG dose density was 100% [40mg/kg/day for 4days].Two patient died one 62years old female in less than 4week of therapy due to fungal pneumonia and 2 case was 19years old male suicide at 7weeks of therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11747885	SGI-1027 emerged as a promising lead compound, and structure–activity relationship (SAR) studies revealed that the terminal residues play a key role in its inhibitory effect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8751435	Significant difference from the control (p < .05), **Very significant difference from control (p < .01) In experiment of western blotting (Figure 6a,b), apoptosis‐related proteins, such as cleaved‐caspase‐3 and pyroptosis‐related protein GSDME‐NT, were increased in CME‐treated A549 cells, whereas they were downregulate...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740207	Human VSELSCs are small cellular structures, typically measuring 5–7 µm in diameter, and exhibit unique embryonic or multipotent characteristics, including the ability to SD and differentiate into various cell types (Sovalat et al., 2011; Shin et al., 2012; Vojnits et al., 2014; Kakavoulia, 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8409415	Nine out of 29 women underwent surgical biopsy in the NACT group and three women were excluded from the investigation as the samples were too small to perform immunohistochemistry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10877303	Therefore, this computational investigation could aid in the development of efficient therapeutics for life-threatening MERS-CoV infections.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "this", "computational", "invest...
PMC11790971	a–c The trends of the classification performance during the feature selection process using RFE for each passage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "a", "–", "c", "The", "trend...
PMC11721277	6-(2-(tert-butoxycarbonyl)hydrazinyl)nicotinic acid (2) and chlorin p6 trimethyl ester (3) were prepared according to reported procedures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "6-(2-(tert-butoxycarbonyl)hydrazinyl)nicotinic", ...
PMC11139449	This experiment successfully validated the presence of the required gRNA constructs in the respective vectors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "experiment", "successfully", "validated", "the", "presenc...
PMC10761218	However, systemic scientific research on this plant began in the 1950s only .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "systemic", "scientific", "research", "on", "this", "plant",...
PMC11742670	To address these challenges, this paper presents an Artificial Intelligence (AI) model that combines the capabilities of Deep Learning (DL) to identify potential new drug candidates, Fuzzy Rough Set (FRS) theory to determine the most important chemical compound features, Explainable Artificial Intelligence (XAI) to exp...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10993311	There was no effect of group or time*group interaction on these parameters.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "was", "no", "effect", "of", "group", "or", "time*group", "interaction",...
PMC9429973	This msPCR assay was applied on an independent cohort of 613 CLL patients (575 CLL, 38 monoclonal B-cell lymphocytosis).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "msPC...
PMC11525028	Data are presented as the mean ± SD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "presented", "as", "the", "mean", "±", "SD", "." ] } ]
PMC11754784	In contrast, control cell groups showed no obvious fluorescence signal no matter incubated with DNP3 or DNP1 (Fig. 4f, and Supplementary Fig. 24).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11591030	The contents of antioxidant indicators (SOD, GPx, CAT, T-AOC, MDA, 8-OHdG, PC, and ROS activity or content) in the culture medium, as well as the expression of genes related to the NF-κB and Nrf2 pathways, were measured.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11098378	This suggests that enhanced arbovirus replication observed in effector treatments was unlikely due to generalized effects on cell viability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "suggests", "that", "enhan...
PMC9429973	The updated analysis confirms asciminib as a treatment option for pts with CML-CP with T315I, including those for whom treatment with PON has failed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC7305184	Furthermore, we would expect the shift between EP and control groups to become bigger with each generation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "we", "would", "exp...
PMC3730428	To model the impact of SMCs in mesothelioma, we selected four MPM cell line models with different levels of cIAP1, cIAP2 and XIAP expression (Figure 1a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11543935	D-E: Relative metabolic activity of [N=8] collagen-based hydrogels 24 hours after treatment with the Stimulate IRE at E = 1000 V/cm with 25 cycles of 8 pulses for D: Cultivated with 1 × 106 HCC-827 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11731614	Microfluidics.	[ { "tags": [ "O", "O" ], "tokens": [ "Microfluidics", "." ] } ]
PMC11453018	B Transcriptional levels (RNA-Seq) of LMNB1 and P15 following EWS::FLI1 knockdown (96 hours) reveals reduction of LMNB1 and induction of P15.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11499381	In the images, the BiFC signal is presented in greyscale.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "images", ",", "the", "BiFC", "signal", "is", "presented", "in", "g...
PMC9429973	The median time between HSCT and the interview was of 26 months (17-39).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "median", "time", "between", "HSCT", ...
PMC9693627	Approximately 10 cells were collected, washed with PBS and lysed in 1 mL of 10 mM HEPES pH 7.4, 120 mM KCl, 20 mM magnesium acetate, 5 mM β-mercaptoethanol, 1.7% Triton X-100 for 30 min on ice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742047	Even if doxorubicin, used as a reference pro-apoptotic drug, did not induce a significant change in caspase 3/7 activity in comparison to not-treated cells (Ctr), the increase in the cleavage of caspase substrate Z-DEVD-rhodamine was more evident in comparison to that obtained with CBD.Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11049548	In spite of the finite lifespan of primary cells and their limited replicative capacity , we could successfully obtain enough samples for metabolomics profiling via H NMR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9428827	The graph represents the ratio between percentages of CD8T lymphocytes and Treg referred to as total CD45 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "graph", "represents", "the...
PMC10213179	Ex vivo imaging of major organs and tumors after euthanasia, 72 h after i.v.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ex", "vivo", "imaging", "of", "major", "organs", "and", ...
PMC9429973	Aims: Exploring safe and efficient methods to target hematopoietic cells carrying SRSF2 mutations might be a powerful tool not just for leukemia prevention and treatment, but also to understand the mechanisms behind SRSF2 mutations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11536589	The high expressed genes in MRTX1133-resistant cells were associated with Notch signaling, angiogenesis, and regulation of Hippo signaling (Fig. S2D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Methods: An observational, non-interventional, retrospective study of 136 patients (54.4% females) with confirmed diagnosis of SCD was conducted in North Lebanon.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8303372	The result suggests that, even though the encapsulated GA was not capable of reaching the cellular compartments with the same efficacy as the free form of GA (see following Section 2.5, Determination of intracellular concentration of GA), the released GA levels by NPs were high enough to interfere with the cellular fun...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11546117	One day before the experiments, the medium was changed (0.3 mL apical and 0.72 mL basolateral).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "day", "before", "the", ...
PMC11653533	The synthesis of the gathered data yielded a complete picture of the wide range of biological activity demonstrated by different species of Ficus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11604830	No fixation of the sample was performed to avoid signal alteration by formalin addition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "fixation", "of", "the", "sample", "was", "performed", "to"...
PMC9587298	As observed for O-3 substituted anthocyanins, these O-3 substituted flavonols also showed the formation of mono- and di-MGO adducts when incubated with MGO at the conditions used in this work and inferred by the observation of new ions in the ESI-MS spectra.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9065483	Corresponding secondary antibodies were applied for 1 h, then samples were mounted onto glass slides and counterstained using Prolong gold anti-fade with DAPI (Molecular Probes).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	On the contrary, JAK2 mutational status had no significant association with spleen size in PMF (P=0.847) but was significantly associated with higher spleen size in SMF (P=0.035).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11764090	Interestingly, there is a close relationship between drought stress and cold stress.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "there", "is", "a", "close", "relationship", "between"...
PMC9874064	We found that the green fluorescence intensity in the cell nucleus treated with NP-Pt-USP1i was significantly higher than that of cells treated with other drugs by CLSM, indicating that cells treated with NP-Pt-USP1i had significantly increased expression of γ-H2AX (Fig. 4G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11790599	This process involves regulatory factors such as Na+/H+ exchanger, V-ATPase, actin polymerization, RAC1, and cholesterol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "process", "involves", "re...
PMC10976516	Still, transformed tumor cells do have the capacity to metastasize and preferentially home into specific organs for that matter.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Still", ",", "transformed", ...
PMC9386809	Structure representing the cone conformation and the location of the Zr atom from the plane of the calixarene ring [CCDC number 2022513].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11695623	Spread the diluted matrigel (Corning, USA) evenly in the upper chamber of transwell and wait for it to solidify.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Spread", "th...
PMC11670954	Images were captured via a fluorescence microscope (N-SIM/C2si, Nikon, Japan).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Images", "were", "captured", "via", "a", "fluorescence", "microscope",...
PMC11719944	Conversely, in some people, poor insulin secretion has been linked to chronic hyperprolactinemia .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Conversely", ",", "in", "some", "people", ",", "poor", ...
PMC10849234	We compared the degranulation activity in our stimulated NLCs to unstimulated NLCs, or to NLCs activated with phorbol 12-myristate 13-acetate (PMA), which can activate neutrophils to produce reactive oxygen species (ROS), but does not activate granule exocytosis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10565698	Cell proliferation was analyzed using the EdU Kit reagent (RiboBio, Guangzhou, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "proliferation", "was", "analyzed", "using", "t...
PMC6627640	Previous studies have linked increased PRC2-mediated epigenetic changes with cancer drug resistance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Previous", "studies", "have", "linked", "increased", "PRC2-mediated", "epigenetic", "c...
PMC4816271	Codon optimization was performed by de-novo gene-synthesis using PCR assembly of overlapping oligonucleotides (IDT DNA, Coralscille Ioha).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Codon", "optimization", "was...
PMC9429973	Summary/Conclusion: Acquired von Willebrand syndrome is a very heterogeneous hemorrhagic syndrome, usually characterized by mild to moderate hemorrhagic symptoms, which can be severe and life-threatening in some cases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8567602	To test the interaction between SMARCB1 and BAF complexes in synovial sarcoma cells further, we applied short interfering RNA (siRNA) against SMARCB1 to reduce its presence in HSSYII and ASKA cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11656380	Therefore, we investigated the effect of a macropinocytosis inhibitor on CCRF-CEM cells to determine whether the uptake of Tamra-Tat-Ram13 is mediated by macropinocytosis (Figure 4B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: Pts with histologically confirmed MZL, ECOG performance status ≤2, and ≥1 prior therapy (including ≥1 CD20-directed regimen) received oral acala 100 mg twice daily until disease progression or unacceptable toxicity ± R. The primary objective was overall response rate (ORR; Lugano criteria as assessed by the in...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806182	Summary statistics for AURKA were obtained from eqtl-a-ENSG00000087586, while data for PCOS and UCEC were retrieved from finn-b-E4_POCS and ebi-a-GCST006466 in the MRC IEU OpenGWAS database .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10669128	Approximately 21–25% of patients affected by STSs display VEGF overexpression, which correlates with a more advanced tumor grade and a worse prognosis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Conditioning regimen was melphalan-based in 96%, with 15.9% being oral melphalan.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Conditioning", "regimen", "was", "melphalan-based", "in", "96", "%", ...
PMC11678368	The obtained IC50 ± SD (µM) values are shown in Figure 5 and listed in Table S7 in the Supplementary Materials.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11638288	Furthermore, when employing cell lines expressing high levels of NKp46/NCR1 ligands, a reduction in tumor growth rate was observed in wild-type mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10940855	Luciferin solution (50 μL) was added to cells in 24-well plates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Luciferin", "solution", "(", "50", "μL", ")", "was", "added", "to", ...
PMC11718031	Cultures were given two passages in this mixture medium for adaptation before transferring to a final 100% basal media under study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cultures", "...
PMC10538569	The average values ± standard deviation (SD) are shown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "average", "values", "±", "standard", "deviation", "(", "SD", ")", "are", ...
PMC11012012	All remaining PBL subtypes were also SLAMF/CD319-positive.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "remaining", "PBL", "subtypes", "were", "also", "SLAMF/CD319-positive", "." ] } ]
PMC9872547	Since cancer cells are more sensitive to curcumin than normal cells (23), fibroblast cells were treated with higher concentrations of this compound.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11686380	Original blots/gels are presented in Supplementary Figure S2 (D). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Original", "blots/gels", "are", "presented", "in", "Supplementary", "Figure", "S2", ...
PMC11361748	The cells were allowed to rest for 48 h and then subjected to the desired outcome.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", "allowed", "to", "rest", ...
PMC9813422	DNA viruses mainly maintain their genome as episomal DNA, which is important for viral replication and gene expression (1, 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9599726	Finally, as cancer cells appear to be “addicted to iron” and as the TFRC emerged as a new cancer marker , we tested the expression of the TFRC in human GIST tissues and explored possible correlations with clinicopathological criteria and YAP expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	However, there are no data on the significance of the combined expression of these proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "there", "are", "no", "data", "on...
PMC11708541	For HLM and MLM, terfenadine and imipramine employed as controls respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "HLM", "and", "MLM", ",", "terfenadine", "and", "imipramine", "employed", ...
PMC10940855	Cells were plated with varying multiplicity of infections to determine optimal virus dose.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "plated", "with", "varying", "multiplicity", "of", "infecti...
PMC5386478	As shown in Figure 4a, TGM2-v1 silencing significantly compromised cell viability in spheroids that appeared reduced in size and dark in light microscopy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11700247	To functionally validate crosspresentation as a mechanism of enhancing the antitumor effect of CART-19 after RT, we used an adoptive T-cell therapy approach.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10705095	HBA1, HBA2, HBQ1, and HBZ are each composed of 141 amino acid residues, while HBM is composed of 140 amino acids.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC9646302

Notably, A20 is a powerful inhibitor of the NF-κB and MAPK signaling cascade, and LAPTM5 directly promotes A20 degradation by binding with it in HeLa cells in the endolysosomal system .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellL...

PMC11766309

The 3 pathways associated with the most negative correlations were the bile acid metabolism, xenobiotic metabolism, and KRAS signaling pathways.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "3", ...

PMC9429973

D. Blickstein, M. Izak, T. Filipovich- Rimon, O. Garach- Jehoshua, N. Rahimi- Levene, E. Shinar, A. Bar- Chaim, M. Koren-Michowitz Hematology, Shamir Medical Center, Beer Yakov; Magen David Adome, National Blood Services, Ramat Gan; Hematology laboratory; Blood bank, Shamir Medical Center, Beer Yaakov; Magen David Adom...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11420784

Salmonella Typhimurium secretes effector SopF to block host cell autophagy by blocking V-ATPase–recruited ATG16L1 onto bacteria-containing vacuoles .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Salmonella", "Typhimurium", "secretes",...

PMC9429973

Biallelic mutations in CD36 are associated with platelet glycoprotein IV deficiency (PG4D), characterized by macrothrombocytopenia with variable bleeding phenotype (PubMed: 7533783; OMIM: 173510).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11656380

The macropinocytic index in three T-ALL cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "macropinocytic", "index", "in", "three", "T-ALL", "cells", "." ] } ]

PMC9532503

From day 3 onwards, cells were fed with CHO feed, glucose, galactose, U1 and U2 feeds, TE mix, and lipid mix until day 11.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7841067

Thus, AKAP4 may act as a potential therapeutic target for human thyroid cancer.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "AKAP4", "may", "act", "as", "a", "potential", ...

PMC10996034

The present study provides novel drug resistance molecular targets and insights for their clinical application in patients with EOC with Taxol-induced multidrug resistance.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...

PMC11699042

Right, standard error of ED for each specific screened compound.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Right", ",", "standard", "error", "of", "ED", "for", "each", "specific", "screened", ...

PMC9920575

It should be noted that the S. edule wild varietal group extract has an IC50 of 1170 μg/mL , so the S. chinantlense extract is 600 times more effective as an antitumor agent, with similar in effectiveness in inhibiting the proliferation of the same cervical cancer line to that reported in a new cultivar of S. edule cal...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11742047

Although LPC can trigger the activation of caspase 1, which is a major player in the apoptotic process, in AML LPCAT3 is implicated in cancer progression involving iron-mediated lipid oxidation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11377827

HIF-1α: control vs. USP43 sgRNA **P = 0.0024, control vs. 14-3-3 siRNA *P = 0.023, control vs. USP43 sgRNA + 14-3-3 siRNA *P = 0.0186.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10366908

After three additional injections every week (1 × 10 cells/rat), a final booster injection (1 × 10 cells/rat) was performed two days before harvesting spleen cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11707832

They identified the MAN2B1 SNP (rs10411619) in Hispanic patients and the MAN1C1 SNP (rs12130495) in African Americans.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "identified", ...

PMC11286266

Additionally, ATF6α_LD has a conserved region (RTKSRR) related to the FURIN cleavage motif generally described as RX-R-X-[K/R]-R↓ (Nakayama, 1997; Figure 1—figure supplement 4E).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11206251

In addition, it is generally believed that TLR4/NF-κB/MyD88 and JAK2/STAT3 are the important signaling pathways related to inflammation .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "it", ...

PMC3915447

Doxorubicin and folic acid (FA) were purchased from Sigma-Aldrich Chemical Co. (St. Louis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Doxorubicin", "and", "folic", "acid", "(", "FA", ...

PMC11707577

Semi‐quantitative analysis of oligothiophene fluorescence intensity detected in confocal images.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Semi‐quantitative", "analysis", "of", "oligothiophene", "fluorescence", "intensity", "detected", "in", ...

PMC9786247

Indeed, C. burnetii shedding was linked to subclinical mastitis, with elevated levels of somatic cell counts indicative of some inflammation upon infection of the organ .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9712534

Western blot analysis of H58Y/WT and WT/WT cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Western", "blot", "analysis", "of", "H58Y/WT", "and", "WT/WT", "cells", "." ] } ]

PMC8193046

We favored this virtual screening dataset compared to other options because the identified ABCC1 inhibitors (12–15; Fig. 2) were in parallel multitarget ABCB1, ABCC1, and ABCG2 inhibitors, which possibly increased the chance to identify novel lead molecules for broad-spectrum ABCB1, ABCC1, and ABCG2 inhibition.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11742231

New Cell Line Test Experiment: In the tests for new cells, the drugs and cells are separated into the training, validation, and test datasets instead of the interaction pairs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11650848

Withdrawal after randomisation (n = 25) or reasons for exclusion from the intervention are indicated.

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PMC9429973

ATG dose density was 100% [40mg/kg/day for 4days].Two patient died one 62years old female in less than 4week of therapy due to fungal pneumonia and 2 case was 19years old male suicide at 7weeks of therapy.

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PMC11747885

SGI-1027 emerged as a promising lead compound, and structure–activity relationship (SAR) studies revealed that the terminal residues play a key role in its inhibitory effect.

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PMC8751435

Significant difference from the control (p < .05), **Very significant difference from control (p < .01) In experiment of western blotting (Figure 6a,b), apoptosis‐related proteins, such as cleaved‐caspase‐3 and pyroptosis‐related protein GSDME‐NT, were increased in CME‐treated A549 cells, whereas they were downregulate...

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PMC11740207

Human VSELSCs are small cellular structures, typically measuring 5–7 µm in diameter, and exhibit unique embryonic or multipotent characteristics, including the ability to SD and differentiate into various cell types (Sovalat et al., 2011; Shin et al., 2012; Vojnits et al., 2014; Kakavoulia, 2021).

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PMC8409415

Nine out of 29 women underwent surgical biopsy in the NACT group and three women were excluded from the investigation as the samples were too small to perform immunohistochemistry.

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PMC10877303

Therefore, this computational investigation could aid in the development of efficient therapeutics for life-threatening MERS-CoV infections.

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PMC11790971

a–c The trends of the classification performance during the feature selection process using RFE for each passage.

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PMC11721277

6-(2-(tert-butoxycarbonyl)hydrazinyl)nicotinic acid (2) and chlorin p6 trimethyl ester (3) were prepared according to reported procedures.

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PMC11139449

This experiment successfully validated the presence of the required gRNA constructs in the respective vectors.

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PMC10761218

However, systemic scientific research on this plant began in the 1950s only .

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PMC11742670

To address these challenges, this paper presents an Artificial Intelligence (AI) model that combines the capabilities of Deep Learning (DL) to identify potential new drug candidates, Fuzzy Rough Set (FRS) theory to determine the most important chemical compound features, Explainable Artificial Intelligence (XAI) to exp...

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PMC10993311

There was no effect of group or time*group interaction on these parameters.

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PMC9429973

This msPCR assay was applied on an independent cohort of 613 CLL patients (575 CLL, 38 monoclonal B-cell lymphocytosis).

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PMC11525028

Data are presented as the mean ± SD.

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PMC11754784

In contrast, control cell groups showed no obvious fluorescence signal no matter incubated with DNP3 or DNP1 (Fig. 4f, and Supplementary Fig. 24).

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PMC11591030

The contents of antioxidant indicators (SOD, GPx, CAT, T-AOC, MDA, 8-OHdG, PC, and ROS activity or content) in the culture medium, as well as the expression of genes related to the NF-κB and Nrf2 pathways, were measured.

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PMC11098378

This suggests that enhanced arbovirus replication observed in effector treatments was unlikely due to generalized effects on cell viability.

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PMC9429973

The updated analysis confirms asciminib as a treatment option for pts with CML-CP with T315I, including those for whom treatment with PON has failed.

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PMC7305184

Furthermore, we would expect the shift between EP and control groups to become bigger with each generation.

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PMC3730428

To model the impact of SMCs in mesothelioma, we selected four MPM cell line models with different levels of cIAP1, cIAP2 and XIAP expression (Figure 1a).

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PMC11543935

D-E: Relative metabolic activity of [N=8] collagen-based hydrogels 24 hours after treatment with the Stimulate IRE at E = 1000 V/cm with 25 cycles of 8 pulses for D: Cultivated with 1 × 106 HCC-827 cells.

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PMC11731614

Microfluidics.

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PMC11453018

B Transcriptional levels (RNA-Seq) of LMNB1 and P15 following EWS::FLI1 knockdown (96 hours) reveals reduction of LMNB1 and induction of P15.

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PMC11499381

In the images, the BiFC signal is presented in greyscale.

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PMC9429973

The median time between HSCT and the interview was of 26 months (17-39).

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PMC9693627

Approximately 10 cells were collected, washed with PBS and lysed in 1 mL of 10 mM HEPES pH 7.4, 120 mM KCl, 20 mM magnesium acetate, 5 mM β-mercaptoethanol, 1.7% Triton X-100 for 30 min on ice.

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PMC11742047

Even if doxorubicin, used as a reference pro-apoptotic drug, did not induce a significant change in caspase 3/7 activity in comparison to not-treated cells (Ctr), the increase in the cleavage of caspase substrate Z-DEVD-rhodamine was more evident in comparison to that obtained with CBD.Fig.

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PMC11049548

In spite of the finite lifespan of primary cells and their limited replicative capacity , we could successfully obtain enough samples for metabolomics profiling via H NMR.

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PMC9428827

The graph represents the ratio between percentages of CD8T lymphocytes and Treg referred to as total CD45 cells.

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PMC10213179

Ex vivo imaging of major organs and tumors after euthanasia, 72 h after i.v.

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PMC9429973

Aims: Exploring safe and efficient methods to target hematopoietic cells carrying SRSF2 mutations might be a powerful tool not just for leukemia prevention and treatment, but also to understand the mechanisms behind SRSF2 mutations.

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PMC11536589

The high expressed genes in MRTX1133-resistant cells were associated with Notch signaling, angiogenesis, and regulation of Hippo signaling (Fig. S2D).

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PMC9429973

Methods: An observational, non-interventional, retrospective study of 136 patients (54.4% females) with confirmed diagnosis of SCD was conducted in North Lebanon.

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PMC8303372

The result suggests that, even though the encapsulated GA was not capable of reaching the cellular compartments with the same efficacy as the free form of GA (see following Section 2.5, Determination of intracellular concentration of GA), the released GA levels by NPs were high enough to interfere with the cellular fun...

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PMC11546117

One day before the experiments, the medium was changed (0.3 mL apical and 0.72 mL basolateral).

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PMC11653533

The synthesis of the gathered data yielded a complete picture of the wide range of biological activity demonstrated by different species of Ficus.

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PMC11604830

No fixation of the sample was performed to avoid signal alteration by formalin addition.

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PMC9587298

As observed for O-3 substituted anthocyanins, these O-3 substituted flavonols also showed the formation of mono- and di-MGO adducts when incubated with MGO at the conditions used in this work and inferred by the observation of new ions in the ESI-MS spectra.

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PMC9065483

Corresponding secondary antibodies were applied for 1 h, then samples were mounted onto glass slides and counterstained using Prolong gold anti-fade with DAPI (Molecular Probes).

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PMC9429973

On the contrary, JAK2 mutational status had no significant association with spleen size in PMF (P=0.847) but was significantly associated with higher spleen size in SMF (P=0.035).

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PMC11764090

Interestingly, there is a close relationship between drought stress and cold stress.

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PMC9874064

We found that the green fluorescence intensity in the cell nucleus treated with NP-Pt-USP1i was significantly higher than that of cells treated with other drugs by CLSM, indicating that cells treated with NP-Pt-USP1i had significantly increased expression of γ-H2AX (Fig. 4G).

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PMC11790599

This process involves regulatory factors such as Na+/H+ exchanger, V-ATPase, actin polymerization, RAC1, and cholesterol.

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PMC10976516

Still, transformed tumor cells do have the capacity to metastasize and preferentially home into specific organs for that matter.

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PMC9386809

Structure representing the cone conformation and the location of the Zr atom from the plane of the calixarene ring [CCDC number 2022513].

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PMC11695623

Spread the diluted matrigel (Corning, USA) evenly in the upper chamber of transwell and wait for it to solidify.

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PMC11670954

Images were captured via a fluorescence microscope (N-SIM/C2si, Nikon, Japan).

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PMC11719944

Conversely, in some people, poor insulin secretion has been linked to chronic hyperprolactinemia .

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PMC10849234

We compared the degranulation activity in our stimulated NLCs to unstimulated NLCs, or to NLCs activated with phorbol 12-myristate 13-acetate (PMA), which can activate neutrophils to produce reactive oxygen species (ROS), but does not activate granule exocytosis .

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PMC10565698

Cell proliferation was analyzed using the EdU Kit reagent (RiboBio, Guangzhou, China).

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PMC6627640

Previous studies have linked increased PRC2-mediated epigenetic changes with cancer drug resistance.

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PMC4816271

Codon optimization was performed by de-novo gene-synthesis using PCR assembly of overlapping oligonucleotides (IDT DNA, Coralscille Ioha).

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PMC9429973

Summary/Conclusion: Acquired von Willebrand syndrome is a very heterogeneous hemorrhagic syndrome, usually characterized by mild to moderate hemorrhagic symptoms, which can be severe and life-threatening in some cases.

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PMC8567602

To test the interaction between SMARCB1 and BAF complexes in synovial sarcoma cells further, we applied short interfering RNA (siRNA) against SMARCB1 to reduce its presence in HSSYII and ASKA cells.

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PMC11656380

Therefore, we investigated the effect of a macropinocytosis inhibitor on CCRF-CEM cells to determine whether the uptake of Tamra-Tat-Ram13 is mediated by macropinocytosis (Figure 4B).

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PMC9429973

Methods: Pts with histologically confirmed MZL, ECOG performance status ≤2, and ≥1 prior therapy (including ≥1 CD20-directed regimen) received oral acala 100 mg twice daily until disease progression or unacceptable toxicity ± R. The primary objective was overall response rate (ORR; Lugano criteria as assessed by the in...

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PMC11806182

Summary statistics for AURKA were obtained from eqtl-a-ENSG00000087586, while data for PCOS and UCEC were retrieved from finn-b-E4_POCS and ebi-a-GCST006466 in the MRC IEU OpenGWAS database .

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PMC10669128

Approximately 21–25% of patients affected by STSs display VEGF overexpression, which correlates with a more advanced tumor grade and a worse prognosis .

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PMC9429973

Conditioning regimen was melphalan-based in 96%, with 15.9% being oral melphalan.

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PMC11678368

The obtained IC50 ± SD (µM) values are shown in Figure 5 and listed in Table S7 in the Supplementary Materials.

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PMC11638288

Furthermore, when employing cell lines expressing high levels of NKp46/NCR1 ligands, a reduction in tumor growth rate was observed in wild-type mice.

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PMC10940855

Luciferin solution (50 μL) was added to cells in 24-well plates.

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PMC11718031

Cultures were given two passages in this mixture medium for adaptation before transferring to a final 100% basal media under study.

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PMC10538569

The average values ± standard deviation (SD) are shown.

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PMC11012012

All remaining PBL subtypes were also SLAMF/CD319-positive.

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PMC9872547

Since cancer cells are more sensitive to curcumin than normal cells (23), fibroblast cells were treated with higher concentrations of this compound.

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PMC11686380

Original blots/gels are presented in Supplementary Figure S2 (D). (

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PMC11361748

The cells were allowed to rest for 48 h and then subjected to the desired outcome.

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PMC9813422

DNA viruses mainly maintain their genome as episomal DNA, which is important for viral replication and gene expression (1, 2).

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PMC9599726

Finally, as cancer cells appear to be “addicted to iron” and as the TFRC emerged as a new cancer marker , we tested the expression of the TFRC in human GIST tissues and explored possible correlations with clinicopathological criteria and YAP expression.

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PMC9429973

However, there are no data on the significance of the combined expression of these proteins.

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PMC11708541

For HLM and MLM, terfenadine and imipramine employed as controls respectively.

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PMC10940855

Cells were plated with varying multiplicity of infections to determine optimal virus dose.

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PMC5386478

As shown in Figure 4a, TGM2-v1 silencing significantly compromised cell viability in spheroids that appeared reduced in size and dark in light microscopy.

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PMC11700247

To functionally validate crosspresentation as a mechanism of enhancing the antitumor effect of CART-19 after RT, we used an adoptive T-cell therapy approach.

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PMC10705095

HBA1, HBA2, HBQ1, and HBZ are each composed of 141 amino acid residues, while HBM is composed of 140 amino acids.

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