OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC9351137	The chromatin remodeling subunits (CRS) studied in this work are depicted in colours Studies on cell division are increasingly relevant to cancer research.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11806613	E MDA-MB-231 TNBC cells with empty vector control or LRP8 overexpression were treated with OST-01 in a dose-dependent manner for 24 h. Left, cell proliferation was assessed.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11283030	The expression data were log2 (TPM) transformed, TIMER and EPIC algorithms were applied for immune infiltration estimations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expression", "data", ...
PMC11587606	Fig. 3Blocking PKCζ phosphorylation leads to suppression of RHBDF1-facilitated disruption of cell polarity and TJ/AJ functions. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "3Blocking", "PKCζ", "phosphorylation", "l...
PMC11258145	These effects are compared to other protective natural dyes like lutein and zeaxanthin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "effects", "are", "compared", "to", "other", "protective", "natural...
PMC7338939	But the others show the negative killing factor, which indicated that DAPT controlled the tumor growth.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "But", "the", "others", "show", "the", "nega...
PMC11599565	The amplification of 100 ng of cDNA was performed in triplicate with 250 nmol primers in PrimeTime® Gene Expression Master Mix (IDT, Iowa, USA) on a CFX96TM Real-Time System (Biorad Laboratories, CA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11591038	In contrast, however, excessive HIF-1 activity may have detrimental effects on microglia in AD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",", "however", ",", "excessive", ...
PMC9622879	However, not every MILP is an NP-hard problem.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "not", "every", "MILP", "is", "an", "NP-hard", "problem", "." ] } ]
PMC10778532	In addition, we tested the ability of migration via transwell assay (Figure 1G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "we", "tested", "the"...
PMC9429973	Another logistic regression was performed to evaluate whether D-d levels at ICU admission influenced prognosis (survivor vs non-survivor), however we didn´t find any differences statistically significant (p=0.727).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11770746	The high antitumor efficacy of Pt(IV) prodrugs and their micellar counterparts and the low level of neuropathic pain associated with them make them ideal candidates for clinical use in cancer therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The mRNA expression levels of Drp1, Opa1, Mfn1, and Mfn2 are measured by real-time fluorescent quantitative polymerase chain reaction (RT-qPCR).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10671321	A total of 500 µL of cold extraction buffer was added per 10 cm dish.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "total", "of", "500", "µL", "of", "cold", "extrac...
PMC11247842	Because of having two lead SNPs, there are two ‘nearest genes’ to this QTL: LRP1 and STAT6.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Because", "of", "...
PMC8348645	The result obtained in this study shows the presence of the bioactive compounds which are effective in the prevention of the proliferation of HepG2 cells in vitro.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", ...
PMC9429973	Indexed samples were run together on a NextSeq 500 instrument (Illumina Inc.) with a 2 × 150-bp paired-end protocol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Indexed", "samples", ...
PMC11190538	6 A) Changes in pH of yogurt during 21 days of storage at 5 °C Fig. 6 B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "6", "A", ")", ...
PMC11544122	Data represent the mean ± SD from four independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "represent", "the", "mean", "±", "SD", "from", "four", "independent", "experiments", ...
PMC5673955	As expected for a telomerase inhibitor, RrA affected proliferation and survival only after a required sufficient telomere shortening (Fig. 7).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", ...
PMC11640247	COS7 cells were seeded in 35 mm culture dishes and transfected with pCAG-Myc-RAC3 or -Myc-RAC3-R66W (0.3 μg each).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "COS7", "cells", "we...
PMC11638255	Raw counts were normalized through natural-log transformation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Raw", "counts", "were", "normalized", "through", "natural-log", "transformation", "." ] } ]
PMC9599726	We next assessed lipid peroxidation in both GIST882 and GIST48 cells (Figure 5, left and right panels).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "next", ...
PMC11562028	However, because of the numerous types of cancer, rapid deterioration and metastasis of tumors, and strong toxic side effects of drugs in clinical treatment, it is still necessary to continue exploring new CDs drugs with good therapeutic effects to meet practical needs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11718109	For the maintenance of iPSCs in culture, iPSCs were cultured on Geltrex (Life Technologies) coated dishes and maintained in Essential 8 Flex media (Thermo Fisher Scientific).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11366496	The pLVX‐Puro‐RNF122 overexpression plasmid was constructed, followed by the transfection of LN‐229 and A‐172 cells with the respective expression plasmid.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "pLVX‐Puro‐RNF122...
PMC7759933	The 2D cultures traditionally used for studying the genotoxic effects of chemicals have several limitations, which consequently lead to misleading results.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "2D", ...
PMC11012313	During Stage II latency, which is found in germinal center B cells and EBV-associated lymphomas, there is more restriction on gene expression in which EBNA-1, LMP1, LMP2A, EBERs, and miRNAs are produced.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11530949	Biometallic nanoparticles (NPs) have emerged as a promising approach to address these challenges.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Biometallic", "nanoparticles", "(", "NPs", ")", "have", "em...
PMC4443654	Co-binding of CTCF and YY1 may also therefore be a contributing factor in the establishment of TAD boundaries, which appear to be broadly conserved across mammals .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10470467	Studies have revealed that a number of illnesses, including malignant tumors, involve the JAK/STAT pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Studies", "have", "revealed", "that", "a", ...
PMC11522251	Activating mutations in PIK3CA and loss of PTEN have been shown to be the causes of primary resistance to cetuximab in the PIK3CA/AKT/mTOR signaling pathway .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC2614415	We predicted that ovarian cancer patients who overexpress Aurora-A would have a higher chance of becoming resistant to taxanes and possibly benefit from a different treatment strategy targeted at Aurora-A and other Aurora family members.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11476264	Immunostaining also showed that FBXO11 depletion increased the expression of ZEB1 and decreased E-cadherin (Figure 4B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immunostaining", "also", "showed", "that", ...
PMC11186948	We identified an unreported de novo variant in HDAC2: c.1330_1333del, p.(K444Lfs*61), predicted to be likely pathogenetic according to ACMG guidelines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11720808	OS cells were seeded onto sterilized coverslips and allowed to attach for 16 h. After treatment with different concentrations of SCU for 24 h, the cells were fixed in 4% paraformaldehyde for 15 minutes at room temperature (RT).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11697065	Manufacturer’s instructions were followed throughout.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Manufacturer", "’s", "instructions", "were", "followed", "throughout", "." ] } ]
PMC11627398	The 2 method was applied to calculate the relative expression of each gene .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "2", "method", "was", "applied", "to", "calculate", "the", "rel...
PMC11543885	Upload the filtered data to the STRING portal (https://string-db.org/).b.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Upload", "the", "filtered", "data", "to", "the", "STRING", "portal", "(https://string-db.org/).b", "." ...
PMC9693627	Moreover, PTCD2 was found co-sedimentated with associated mitoribosome but not with SSU or LSU alone.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "PTCD2", "was", "found", "co-sedimenta...
PMC11718817	This could also explain the additional peak in higher arrest coefficients at the late time point compared to the early time point (Supplementary Figure S4A,B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11741906	Off-target effects remain a critical concern since miRNAs regulate multiple pathways, and alterations in their expression may have unintended systemic consequences .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Off-target", ...
PMC11507371	Sun et al. questioned the previously accepted cytosolic location of Keap1 and proved its constant shuttling between the nucleus and cytoplasm under basal conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Age was not a statistical significant variable for willingness to participate (p=0.64).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Age", "was", "not", "a", "statistical", "significant", "variable", ...
PMC9429973	This was found to be statistically significant for two of four drugs (P<0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "was", "found", "to", "be", "statistically", "signif...
PMC11525028	The results showed that the mRNA and protein levels of NAT10 were significantly increased in tumor samples and osteosarcoma cell lines (Figures 1L and 1M).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11723947	b, d Percentage of semi-allogeneic (H-2K) cells among PBMC 21 days after engraftment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "b", ",", "d", "Percentage", "of", "semi-all...
PMC11772585	Similarly, upregulated METTL1 and WDR4 have been identified in HNSCC and correlated with a negative prognosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similarly", ",", "upregulated", "METTL1", "and", ...
PMC11682525	Interestingly, we observed remarkably similar alterations in the expression of these targeted genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "we", "observed", "remarkably", "similar", "alter...
PMC11604015	More deeper explorations on relapse mechanisms after T-targeted CAR-T cell therapy may help to address this problem.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "More", "deeper", "explorations", "on", "relapse",...
PMC8978939	L163R variant was identified in 2 patients of a family with pheochromocytoma only (Type 2C VHL).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "L163R", "variant", "was", "identified", ...
PMC11640476	In conclusion, our optimized approach for resazurin-based assays on A549 cells provides a reliable tool for cytotoxicity testing, which advances the standardization necessary for robust pre-clinical drug screening.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Moreover, Lauren K. Meyer et al. demonstrate that ruxolitinib can reverse the resistance of CD8 positive T cells to dexamethasone in hypercytokinemia of HLH.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10938336	AML is the most typical type of childhood cancer, and children under the age of 15 are more prone to it.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "AML", "is", ...
PMC9895440	transfer of 0.5 Mio human CD8 anti-CD19-28z CAR T cells with or without SNX9 KO (mean and SEM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "transfer", "...
PMC10907726	Fig. 4 The overview of RNA-seq. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "4", "The", "overview", "of", "RNA-seq", ".", "(" ] } ]
PMC9429973	The majority (43/52 [82.7%]) had a diagnosis of de novo AML, and the genetic risk (according to ELN2017 criteria) was favorable for 13/52 (25.0%), intermediate for 22/52 (42.3%) and adverse for 17/52 (32.7%) of the patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9545474	Cell lines were provided by the Institute of Cancer Therapeutics, University of Bradford, UK.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "lines", "were", "provided", "by", "the", ...
PMC10854447	Compound 7j (R = 2,4-di-Cl) was the third most active against the four cancer cell lines, with a GI50 value of 35 nM. Compound 7j was likewise more potent than Erlotinib against the breast cancer (MCF-7) cell line, with an IC50 value of 36 ± 3 nM versus Erlotinib’s IC50 of 40 ± 3 nM. Another key point drawn from the fi...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11730000	Genotoxicity is one of the most important mechanisms of adverse effects associated with DOX therapy as an anticancer drug.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Genotoxicity", "is", "one", "of",...
PMC9429973	This has potential implications for management of axi-cel patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "has", "potential", "implications", "for", "management", "of", "axi-cel", "patients", "." ] } ...
PMC10024132	These results suggest that ex vivo expanded γ9δ2 T cells can be used as effector cells for blinatumomab.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "suggest", "that", ...
PMC9822769	However, several experimental results suggested that active or facilitated transport contributes to cisplatin uptake and is clearly involved in intrinsic or acquired resistance [30–32].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7823217	Future studies should focus on the approaches that help to miniaturize the bioprinted constructs suitable for automated workflow systems that are less labour -intensive and cost-effective.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11228511	We suspect that progerin’s capacity to affect the structure of the lamin B1 meshwork reflects direct protein–protein interactions between the two meshworks, or alternatively, the formation of mixed heteropolymers containing both lamin B1 and progerin (34).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7887261	The discovery set included 1094 LC cases and 933 controls from the TRICL study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "discovery", "set", "included", "1094", "LC", "cases", "an...
PMC7602170	When those inhibitors of PI3K (with LY294002), AKT (with Akti-1/2) or mTOR (with rapamycin) were separately applied to Abl-transformed cells, the phosphorylation of eIF4B Ser422 markedly decreased, which inhibited cell proliferation and growth .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7553912	The apparent molecular weights are indicated on the right. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "apparent", "molecular", "weights", "are", "indicated", "on", "the", "right", ".", "...
PMC8357004	These changes can be reversed by DNA demethylating agents, such as decitabine, 5-Aza-2′-deoxycytidine (5-Aza-CdR), and histone deacetylase inhibitors (HDACIs), such as trichostatin A. Previously, we reported the effect of 5-Aza-CdR and trichostatin A (TSA) on hepatocellular carcinoma (HCC).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10502403	Gene expression associated with the “oxidative phosphorylation” of WikiPathways was higher in NE1-GMCs than in NGMCs in the stimulated state (Figures 4B and Table 1).Figure 4Transcriptomic analysis of NGMCs and NE1-GMCsGene set enrichment analysis (GSEA) between NE1-GMCs purified with CD8 microbeads and NGMCs under uns...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10213179	Human recombinant EphA2 was immobilized and the binding kinetics with different concentrations of ATOP was measured (Figure 4A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Human", "recombinant", "EphA...
PMC10850553	Scale bar: 50 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ":", "50", "μm", "." ] } ]
PMC10652261	Pyrazoline moiety is highly prevalent with lipophilic characteristics and soluble in most organic solvents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pyrazoline", "moiety", "is", "highly", "prevalent", "with", "lipophili...
PMC11297139	The colors indicate normalized read count in the regions and normalized gene expression, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "colors", "indicate", "normalized", "read", "count", ...
PMC11532793	In panel (A), the line of equality is shown as a gray dashed line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "panel", "(", "A", ")", ",", "th...
PMC10706275	The C12orf35 locus on chromosome 8 in CHO cells, the HPRT locus in CHO cells, the Hipp11 gene in CHO-S cells, and the Kcmf1 gene in CHO-K1 cells serve as examples of potentially viable integration sites .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O"...
PMC11434983	The experiment was performed in tetraplicate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "experiment", "was", "performed", "in", "tetraplicate", "." ] } ]
PMC10523483	Histones H1.2 is a predominant somatic linker histone variant playing multiple functions in gene transcription, cell cycle, autophagy, and apoptosis (20–22), while its role in NSCLC remains poorly understood.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Image: Summary/Conclusion: These findings indicate that oxygen gradient ektacytometry generates novel clinically relevant biomarkers and provide a rationale for further development of these biomarkers in the evaluation of novel therapies, as part of clinical care, or clinical trial endpoints.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11794847	A-B: CCK8 assay was performed in lung cancer cells co-cultured with control, jurkat, and activated T cells; C-E: Colony formation assay was performed in lung cancer cells co-cultured with control, jurkat, and activated T cells; F–H: EdU assay was performed in lung cancer cells co-cultured with control, jurkat, and acti...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754094	To investigate whether the high frequency of large deletions is still maintained, two nicking gRNAs were used for substitution edits. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "invest...
PMC8068766	For finding novel genes for diagnosis and targeted therapy, it is crucial to determine cancer cell characteristics in more detail and provide more insight into molecular mechanisms behind carcinogenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10530622	All stimuli increased β-galactosidase (SA-βgal) activity and protein carbonyl content (oxidative stress indicator) and decreased telomere length-regulated proteins mRNA (TRF1, TRF2 and POT1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11543885	Subsequently, the cells were incubated with biotin phenol and then H2O2, as specified.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", "the", "cells", "were", "incubated", "w...
PMC11787651	This could potentially stem from the challenge of resolving the peptide containing this mark from the isomer containing H3K14ac.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "could", "potentially", "s...
PMC9429973	Patients who receive RT involving the mediastinum have a prolonged T-cell deficit and might benefit from longer Pneumocystis pneumonia prophylaxis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "who", "receive",...
PMC11173119	from the Myco-Visor Mycoplasma Detection Kit (Biolabmix, Novosibirsk, Russia).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "from", "the", "Myco-Visor", "Mycoplasma", "Detection", "Kit", "(", "Biolabm...
PMC10297204	Accordingly, ethanol concentrations of 0%, 30%, and 99.5% were applied to in vivo assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Accordingly", ",", "ethanol"...
PMC11643361	The tested iron complex (38) inhibits cell migration in human cell lines (HaCaT and HCT116) but promotes it in the murine (B16) cell line, and displays no cytotoxicity against the tested human cell lines but enhances the viability of the murine cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "...
PMC11765988	The persistence and progression of lymphoma following the discontinuation of prednisone may contribute to the recurrence of sarcoidosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "persistence", "and", "progression", ...
PMC10940855	Silencing the expression of several candidate genes in HAECs had no effect on multiple myeloma growth in coculture (Supplementary Fig. S1B) but silencing the expression of EPH receptor B1 (EPHB1) in HAECs suppressed multiple myeloma cell expansion in coculture (Fig. 2A and B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594074	However, the demethylated metabolite S-adenosyl-L-homocysteine (SAH) is also capable of binding to DNMT1, thereby inhibiting its ability to catalyze a methyl transfer to DNA .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11799620	This study’s results demonstrated the free radical scavenging ability of cactus aqueous extract.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "study", "’s", "results", "demonstrated", "the", "free", ...
PMC9429973	In the remaining’s (43.8%) the most frequent alloantibody types were against Rh antigens and anti-E was found to the most common encountered (12.5%) antibody.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6379402	We use this property to assess the robustness of the decompositions and to fix the number of gene clusters, k (see Methods, section Fixing the number of clusters).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6901583	Conditioned media were collected for ELISA assays to assess VEGFA secretion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Conditioned", "media", "were", "collected", "for", "ELISA", "assays", "to", "assess", ...
PMC11721587	The supernatant and pellet were collected for further analysis by Western blot.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "supernatant", "and", "pellet", "were", "collected", "for", "further", "an...
PMC11742047	Certain bioactive lipids seem to be involved in the promotion of apoptosis by activation of the intrinsic pathway, by modulating mitochondrial membrane permeability and by activating different enzymes including caspases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9545714	Among the most used supplements are, in order of decreasing use: fish oil, glucosamine/chondroitin, probiotics/prebiotics, melatonin, coenzyme Q10, echinacea, cranberry pills, garlic extract, ginseng, and gingko biloba.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7342409	It has been reported that autophagy can promote the survival of GIST cells and induce drug resistance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "been", "reported", "that", "au...

PMC9351137

The chromatin remodeling subunits (CRS) studied in this work are depicted in colours Studies on cell division are increasingly relevant to cancer research.

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PMC11806613

E MDA-MB-231 TNBC cells with empty vector control or LRP8 overexpression were treated with OST-01 in a dose-dependent manner for 24 h. Left, cell proliferation was assessed.

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PMC11283030

The expression data were log2 (TPM) transformed, TIMER and EPIC algorithms were applied for immune infiltration estimations.

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PMC11587606

Fig. 3Blocking PKCζ phosphorylation leads to suppression of RHBDF1-facilitated disruption of cell polarity and TJ/AJ functions. (

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PMC11258145

These effects are compared to other protective natural dyes like lutein and zeaxanthin.

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PMC7338939

But the others show the negative killing factor, which indicated that DAPT controlled the tumor growth.

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PMC11599565

The amplification of 100 ng of cDNA was performed in triplicate with 250 nmol primers in PrimeTime® Gene Expression Master Mix (IDT, Iowa, USA) on a CFX96TM Real-Time System (Biorad Laboratories, CA, USA).

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PMC11591038

In contrast, however, excessive HIF-1 activity may have detrimental effects on microglia in AD.

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PMC9622879

However, not every MILP is an NP-hard problem.

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PMC10778532

In addition, we tested the ability of migration via transwell assay (Figure 1G).

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PMC9429973

Another logistic regression was performed to evaluate whether D-d levels at ICU admission influenced prognosis (survivor vs non-survivor), however we didn´t find any differences statistically significant (p=0.727).

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PMC11770746

The high antitumor efficacy of Pt(IV) prodrugs and their micellar counterparts and the low level of neuropathic pain associated with them make them ideal candidates for clinical use in cancer therapy.

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PMC9429973

The mRNA expression levels of Drp1, Opa1, Mfn1, and Mfn2 are measured by real-time fluorescent quantitative polymerase chain reaction (RT-qPCR).

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PMC10671321

A total of 500 µL of cold extraction buffer was added per 10 cm dish.

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PMC11247842

Because of having two lead SNPs, there are two ‘nearest genes’ to this QTL: LRP1 and STAT6.

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PMC8348645

The result obtained in this study shows the presence of the bioactive compounds which are effective in the prevention of the proliferation of HepG2 cells in vitro.

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PMC9429973

Indexed samples were run together on a NextSeq 500 instrument (Illumina Inc.) with a 2 × 150-bp paired-end protocol.

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PMC11190538

6 A) Changes in pH of yogurt during 21 days of storage at 5 °C Fig. 6 B).

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PMC11544122

Data represent the mean ± SD from four independent experiments.

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PMC5673955

As expected for a telomerase inhibitor, RrA affected proliferation and survival only after a required sufficient telomere shortening (Fig. 7).

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PMC11640247

COS7 cells were seeded in 35 mm culture dishes and transfected with pCAG-Myc-RAC3 or -Myc-RAC3-R66W (0.3 μg each).

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PMC11638255

Raw counts were normalized through natural-log transformation.

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PMC9599726

We next assessed lipid peroxidation in both GIST882 and GIST48 cells (Figure 5, left and right panels).

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PMC11562028

However, because of the numerous types of cancer, rapid deterioration and metastasis of tumors, and strong toxic side effects of drugs in clinical treatment, it is still necessary to continue exploring new CDs drugs with good therapeutic effects to meet practical needs.

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PMC11718109

For the maintenance of iPSCs in culture, iPSCs were cultured on Geltrex (Life Technologies) coated dishes and maintained in Essential 8 Flex media (Thermo Fisher Scientific).

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PMC11366496

The pLVX‐Puro‐RNF122 overexpression plasmid was constructed, followed by the transfection of LN‐229 and A‐172 cells with the respective expression plasmid.

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PMC7759933

The 2D cultures traditionally used for studying the genotoxic effects of chemicals have several limitations, which consequently lead to misleading results.

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PMC11012313

During Stage II latency, which is found in germinal center B cells and EBV-associated lymphomas, there is more restriction on gene expression in which EBNA-1, LMP1, LMP2A, EBERs, and miRNAs are produced.

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PMC11530949

Biometallic nanoparticles (NPs) have emerged as a promising approach to address these challenges.

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PMC4443654

Co-binding of CTCF and YY1 may also therefore be a contributing factor in the establishment of TAD boundaries, which appear to be broadly conserved across mammals .

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PMC10470467

Studies have revealed that a number of illnesses, including malignant tumors, involve the JAK/STAT pathway.

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PMC11522251

Activating mutations in PIK3CA and loss of PTEN have been shown to be the causes of primary resistance to cetuximab in the PIK3CA/AKT/mTOR signaling pathway .

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PMC2614415

We predicted that ovarian cancer patients who overexpress Aurora-A would have a higher chance of becoming resistant to taxanes and possibly benefit from a different treatment strategy targeted at Aurora-A and other Aurora family members.

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PMC11476264

Immunostaining also showed that FBXO11 depletion increased the expression of ZEB1 and decreased E-cadherin (Figure 4B).

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PMC11186948

We identified an unreported de novo variant in HDAC2: c.1330_1333del, p.(K444Lfs*61), predicted to be likely pathogenetic according to ACMG guidelines.

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PMC11720808

OS cells were seeded onto sterilized coverslips and allowed to attach for 16 h. After treatment with different concentrations of SCU for 24 h, the cells were fixed in 4% paraformaldehyde for 15 minutes at room temperature (RT).

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PMC11697065

Manufacturer’s instructions were followed throughout.

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PMC11627398

The 2 method was applied to calculate the relative expression of each gene .

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PMC11543885

Upload the filtered data to the STRING portal (https://string-db.org/).b.

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PMC9693627

Moreover, PTCD2 was found co-sedimentated with associated mitoribosome but not with SSU or LSU alone.

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PMC11718817

This could also explain the additional peak in higher arrest coefficients at the late time point compared to the early time point (Supplementary Figure S4A,B).

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PMC11741906

Off-target effects remain a critical concern since miRNAs regulate multiple pathways, and alterations in their expression may have unintended systemic consequences .

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PMC11507371

Sun et al. questioned the previously accepted cytosolic location of Keap1 and proved its constant shuttling between the nucleus and cytoplasm under basal conditions.

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PMC9429973

Age was not a statistical significant variable for willingness to participate (p=0.64).

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PMC9429973

This was found to be statistically significant for two of four drugs (P<0.05).

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PMC11525028

The results showed that the mRNA and protein levels of NAT10 were significantly increased in tumor samples and osteosarcoma cell lines (Figures 1L and 1M).

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PMC11723947

b, d Percentage of semi-allogeneic (H-2K) cells among PBMC 21 days after engraftment.

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PMC11772585

Similarly, upregulated METTL1 and WDR4 have been identified in HNSCC and correlated with a negative prognosis.

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PMC11682525

Interestingly, we observed remarkably similar alterations in the expression of these targeted genes.

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PMC11604015

More deeper explorations on relapse mechanisms after T-targeted CAR-T cell therapy may help to address this problem.

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PMC8978939

L163R variant was identified in 2 patients of a family with pheochromocytoma only (Type 2C VHL).

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PMC11640476

In conclusion, our optimized approach for resazurin-based assays on A549 cells provides a reliable tool for cytotoxicity testing, which advances the standardization necessary for robust pre-clinical drug screening.

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PMC9429973

Moreover, Lauren K. Meyer et al. demonstrate that ruxolitinib can reverse the resistance of CD8 positive T cells to dexamethasone in hypercytokinemia of HLH.

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PMC10938336

AML is the most typical type of childhood cancer, and children under the age of 15 are more prone to it.

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PMC9895440

transfer of 0.5 Mio human CD8 anti-CD19-28z CAR T cells with or without SNX9 KO (mean and SEM).

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PMC10907726

Fig. 4 The overview of RNA-seq. (

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PMC9429973

The majority (43/52 [82.7%]) had a diagnosis of de novo AML, and the genetic risk (according to ELN2017 criteria) was favorable for 13/52 (25.0%), intermediate for 22/52 (42.3%) and adverse for 17/52 (32.7%) of the patients.

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PMC9545474

Cell lines were provided by the Institute of Cancer Therapeutics, University of Bradford, UK.

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PMC10854447

Compound 7j (R = 2,4-di-Cl) was the third most active against the four cancer cell lines, with a GI50 value of 35 nM. Compound 7j was likewise more potent than Erlotinib against the breast cancer (MCF-7) cell line, with an IC50 value of 36 ± 3 nM versus Erlotinib’s IC50 of 40 ± 3 nM. Another key point drawn from the fi...

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PMC11730000

Genotoxicity is one of the most important mechanisms of adverse effects associated with DOX therapy as an anticancer drug.

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PMC9429973

This has potential implications for management of axi-cel patients.

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PMC10024132

These results suggest that ex vivo expanded γ9δ2 T cells can be used as effector cells for blinatumomab.

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PMC9822769

However, several experimental results suggested that active or facilitated transport contributes to cisplatin uptake and is clearly involved in intrinsic or acquired resistance [30–32].

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PMC7823217

Future studies should focus on the approaches that help to miniaturize the bioprinted constructs suitable for automated workflow systems that are less labour -intensive and cost-effective.

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PMC11228511

We suspect that progerin’s capacity to affect the structure of the lamin B1 meshwork reflects direct protein–protein interactions between the two meshworks, or alternatively, the formation of mixed heteropolymers containing both lamin B1 and progerin (34).

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PMC7887261

The discovery set included 1094 LC cases and 933 controls from the TRICL study.

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PMC7602170

When those inhibitors of PI3K (with LY294002), AKT (with Akti-1/2) or mTOR (with rapamycin) were separately applied to Abl-transformed cells, the phosphorylation of eIF4B Ser422 markedly decreased, which inhibited cell proliferation and growth .

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PMC7553912

The apparent molecular weights are indicated on the right. (

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PMC8357004

These changes can be reversed by DNA demethylating agents, such as decitabine, 5-Aza-2′-deoxycytidine (5-Aza-CdR), and histone deacetylase inhibitors (HDACIs), such as trichostatin A. Previously, we reported the effect of 5-Aza-CdR and trichostatin A (TSA) on hepatocellular carcinoma (HCC).

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PMC10502403

Gene expression associated with the “oxidative phosphorylation” of WikiPathways was higher in NE1-GMCs than in NGMCs in the stimulated state (Figures 4B and Table 1).Figure 4Transcriptomic analysis of NGMCs and NE1-GMCsGene set enrichment analysis (GSEA) between NE1-GMCs purified with CD8 microbeads and NGMCs under uns...

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PMC10213179

Human recombinant EphA2 was immobilized and the binding kinetics with different concentrations of ATOP was measured (Figure 4A).

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PMC10850553

Scale bar: 50 μm.

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PMC10652261

Pyrazoline moiety is highly prevalent with lipophilic characteristics and soluble in most organic solvents.

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PMC11297139

The colors indicate normalized read count in the regions and normalized gene expression, respectively.

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PMC11532793

In panel (A), the line of equality is shown as a gray dashed line.

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PMC10706275

The C12orf35 locus on chromosome 8 in CHO cells, the HPRT locus in CHO cells, the Hipp11 gene in CHO-S cells, and the Kcmf1 gene in CHO-K1 cells serve as examples of potentially viable integration sites .

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PMC11434983

The experiment was performed in tetraplicate.

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PMC10523483

Histones H1.2 is a predominant somatic linker histone variant playing multiple functions in gene transcription, cell cycle, autophagy, and apoptosis (20–22), while its role in NSCLC remains poorly understood.

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PMC9429973

Image: Summary/Conclusion: These findings indicate that oxygen gradient ektacytometry generates novel clinically relevant biomarkers and provide a rationale for further development of these biomarkers in the evaluation of novel therapies, as part of clinical care, or clinical trial endpoints.

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PMC11794847

A-B: CCK8 assay was performed in lung cancer cells co-cultured with control, jurkat, and activated T cells; C-E: Colony formation assay was performed in lung cancer cells co-cultured with control, jurkat, and activated T cells; F–H: EdU assay was performed in lung cancer cells co-cultured with control, jurkat, and acti...

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PMC11754094

To investigate whether the high frequency of large deletions is still maintained, two nicking gRNAs were used for substitution edits. (

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PMC8068766

For finding novel genes for diagnosis and targeted therapy, it is crucial to determine cancer cell characteristics in more detail and provide more insight into molecular mechanisms behind carcinogenesis.

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PMC10530622

All stimuli increased β-galactosidase (SA-βgal) activity and protein carbonyl content (oxidative stress indicator) and decreased telomere length-regulated proteins mRNA (TRF1, TRF2 and POT1).

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PMC11543885

Subsequently, the cells were incubated with biotin phenol and then H2O2, as specified.

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PMC11787651

This could potentially stem from the challenge of resolving the peptide containing this mark from the isomer containing H3K14ac.

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PMC9429973

Patients who receive RT involving the mediastinum have a prolonged T-cell deficit and might benefit from longer Pneumocystis pneumonia prophylaxis.

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PMC11173119

from the Myco-Visor Mycoplasma Detection Kit (Biolabmix, Novosibirsk, Russia).

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PMC10297204

Accordingly, ethanol concentrations of 0%, 30%, and 99.5% were applied to in vivo assays.

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PMC11643361

The tested iron complex (38) inhibits cell migration in human cell lines (HaCaT and HCT116) but promotes it in the murine (B16) cell line, and displays no cytotoxicity against the tested human cell lines but enhances the viability of the murine cell line.

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PMC11765988

The persistence and progression of lymphoma following the discontinuation of prednisone may contribute to the recurrence of sarcoidosis.

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PMC10940855

Silencing the expression of several candidate genes in HAECs had no effect on multiple myeloma growth in coculture (Supplementary Fig. S1B) but silencing the expression of EPH receptor B1 (EPHB1) in HAECs suppressed multiple myeloma cell expansion in coculture (Fig. 2A and B).

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PMC11594074

However, the demethylated metabolite S-adenosyl-L-homocysteine (SAH) is also capable of binding to DNMT1, thereby inhibiting its ability to catalyze a methyl transfer to DNA .

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PMC11799620

This study’s results demonstrated the free radical scavenging ability of cactus aqueous extract.

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PMC9429973

In the remaining’s (43.8%) the most frequent alloantibody types were against Rh antigens and anti-E was found to the most common encountered (12.5%) antibody.

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PMC6379402

We use this property to assess the robustness of the decompositions and to fix the number of gene clusters, k (see Methods, section Fixing the number of clusters).

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PMC6901583

Conditioned media were collected for ELISA assays to assess VEGFA secretion.

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PMC11721587

The supernatant and pellet were collected for further analysis by Western blot.

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PMC11742047

Certain bioactive lipids seem to be involved in the promotion of apoptosis by activation of the intrinsic pathway, by modulating mitochondrial membrane permeability and by activating different enzymes including caspases.

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PMC9545714

Among the most used supplements are, in order of decreasing use: fish oil, glucosamine/chondroitin, probiotics/prebiotics, melatonin, coenzyme Q10, echinacea, cranberry pills, garlic extract, ginseng, and gingko biloba.

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PMC7342409

It has been reported that autophagy can promote the survival of GIST cells and induce drug resistance.

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