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PMC11204465
The results showed that hydration and hydrogenation of the ∆-double bond significantly reduce the cytotoxicity of aflatoxins, while the esterification at C-8 increases the cytotoxicity .
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PMC11180402
Data are mean ± SD from triplicate samples. *, #,
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PMC9429973
Unfortunately, the risk may increase in pts with aggressive systemic mastocytosis (ASM), or mastocytosis associated to a hematologic neoplasm (SM-AHN).
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PMC11514418
Further, intranasal treatment of APS activated DCs, which further stimulated natural killer and T cells in the mLN.
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PMC10890307
Here, we show that the increased CD98 expression in lung cancer cell lines might be related to the absence of glucose in culture media independent of pH or oxygen tension.
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PMC11727638
Recently, we developed an on-chip cell culture and evaluation system called a “Cell Dome” which is fabricated on a glass substrate and features a dome with a hemispherical cavity (1 mm in diameter and almost 300 µm in height) that provides a 3D cell growth space for enclosed cells .
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PMC11350568
To rigorously validate the system’s proficiency in selectively degrading PTK7, we employed flow cytometry analysis.
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PMC11769516
In addition to MON, DON and its derivative 3-acetyldeoxynivalenol (3-AcDON) were also studied.
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PMC11805741
LC/ESI-MS/MS Mass spectra of antheraxanthin monoester, astaxanthin monoester, zeaxanthin monoester.
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PMC11544122
No. A9469) antibodies were from Sigma-Aldrich (St. Louis, MO).
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PMC11718274
Interpretation of qRT-PCR results revealed that treatment of A-431 cancer cells with Y2O3NPs at concentrations of 7.47, 14.98 and 29.89 µg/ml significantly upregulated the expression level of apoptotic p53 and mitochondrial ND3 genes, while significantly downregulated the anti-apoptotic Bcl2 gene expression in a concen...
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PMC11261875
However, the mechanism underlying these cell growth suppressions is yet to be elucidated .
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PMC11806818
Chen et al. designed a simple voltammetric sensor based on aptamer control of the catalytic activity of Pt NPs/Fe-MOF nanozymes, and selected CEA aptamer as the specific recognition element to capture CEA.
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PMC11519077
IL-6 has been shown to play a key role in experimental colitis, and its high levels are a substantial risk factor for colon cancer and hepatocellular carcinoma in humans .
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PMC10391797
figure 1D).
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PMC11730320
TCRγδ T cell numbers were significantly elevated (343 cells/µL—30% of CD3+ T cells; ref range: 2–3%).
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PMC11591038
HIF-1 critically involved in glucose metabolism mediates neuroprotective effects against Aβ toxicity; further, both HIF-1 and those enzymes in the glycolytic pathways are crucial for neuronal survival over the frontal cortex in AD patients .
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PMC9105697
SS is characterized by the chromosomal translocation t(X;18)(p11;q11), which fuses SS18 (SYT) in chromosome 18 and SSX1, SSX2 or SSX4 in chromosome X .
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PMC11409031
Another study also showed that in most immunotherapy environments, CD8+T lymphocytes can eradicate OV cells and are associated with good patient survival .
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PMC9429973
We created a luciferase positive clone that allows us to detect tumor burden by IVIS as early as one week post engraftment and to track disease progression.
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PMC10376064
The reaction was started by the addition of MgATP (3.3 mM in water; Sigma–Aldrich), and an incubation period of 60 min at 37 °C followed.
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PMC11387401
This could lead to miss-aggregating or miss-trafficking of these proteins within the cell, obscuring the identification of true RNA interactors.
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PMC3035438
To verify the construct integration (Figure 1B), selected stable DT40 transformants were analyzed by PCR amplification of a 4.5-kb fragment from the beginning of chicken CH1 to the marker gene (data not shown).
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PMC11116779
As shown in Figure 4A, PS-NPs were able to significantly induce SA-β-Gal activity, measured in A549 cell lysates, at all the concentrations tested.
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PMC9429973
Patients were required to have a PNH diagnosis based on the International Classification of Diseases 9 or 10 Revision code, a medical visit recorded ≥6 months before index/first RAV treatment, and no record of myasthenia gravis, atypical hemolytic uremic syndrome, or neuromyelitis optica spectrum disorder.
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PMC11467800
This observation may be associated with the recurrence of cancer in patients stemming from a small number of dormant cells that were resistant to therapy as a result of their phenotypic plasticity.
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PMC8735881
Combined, these results finely verified that the bifunctional CMI constructs possess superiority over GPI-10E8 in terms of anti-HIV potency and broad-spectrum.
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PMC11534377
Therefore, in theory 5-Aza could function as a universal treatment enhancer in combination with current therapeutic schemes in oncology or as a safe alternative as singular treatment or in combination with IR for patients at high risk (e.g. advanced age) due to its safe clinical profile.
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PMC11377827
Mean ± sd.
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PMC11585565
In addition to its function as a magnesium transporter, Cnnm4 has an essential role in sperm Ca homeostasis during capacitation.
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PMC11591030
The PBLs was randomly divided into eight treatments with six replicates, namely CON, AOP, LPS, ML385 (Nrf2 inhibitor), AOP + LPS, AOP + ML385, LPS + ML385 and LPS + ML385 + AOP.
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PMC11310713
Quantitative analysis of endometrium thickness through ImageJ software. (
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PMC10578720
The liver stiffness value of vehicle-treated rAAV-1.3 HBV mice was significantly higher than normal mice (16.55±2.68 kPa vs. 9.23±2.11 kPa).
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PMC7887261
For the candidates identified from the association test, we performed G×E interaction (i.e., age-onset, sex, smoking status, pack-years, and FHLC), using the mixed linear regression model.
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PMC10808409
The n-butanol fraction was prepared from Liatris spicata (L.) (10 g) as mentioned in our published data and it was portioned on a diaion HP-20 AG (250 g, 5 × 120 cm) using water, followed by water/methanol (1:1 v/v) and finally with 100% methanol.
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PMC11345828
H NMR (400 MHz, CDCl3) δ 7.75 (d, J = 8.8 Hz, 1H), 7.48 (s, 0.3H), 7.47 (s, 0.7H), 7.34 (d, J = 8.8 Hz, 0.3H), 7.33 (d, J = 8.4 Hz, 0.7H), 6.81 (s, 0.3H), 6.79 (s, 0.7H), 6.60 (s, 1.4H), 6.58 (s, 0.6H), 4.91–4.88 (m, 1H), 4.35 (dd, J = 13.2, 3.6 Hz), 0.3H), 4.16 (dd, J = 13.2, 3.6 Hz, 0.7H), 4.11 (s, 1H), 4.06–3.97 (m,...
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PMC11487720
When cultured at 37℃, UV-treated cells undergo apoptosis, and α-tubulin appears to be shortened but without relocating to the nuclei.
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PMC11659734
It contains both phase I and phase II metabolic enzymes, including the crucial cytochrome P450 (CYP) enzymes.
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PMC11025866
This strategy identified 110 genes upregulated and 182 genes downregulated uniquely by butyrate (Fig 4).
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PMC11377827
Quantification of HIF-1α enrichment within the nuclear fraction in HeLa control or following 14-3-3 siRNA-mediated depletion.
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PMC10745221
When PRMT5 is added with MS023 and SGC8158, it appears that there is less signal intensity in the revertant cell lysates than in the parent cell lysates, indicating that there may be less substrate availability for PRMT5 in the revertant cell lysates.
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PMC11424574
Silencing of uPA expression reduced MDA-MB-231cells migratory, invasive, and adhesive ability and modulated the EMT by down-regulating Oct-4 expression .
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PMC9386809
This leads to the continuous search for potent anticancer drugs for brain cancer with low toxicity and high potency.
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PMC8873393
Data are means ± s.e.m. (
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PMC11806818
Due to the excellent peroxidase activity of H-rGO-Mn3O4 nanozymes, they can catalyze the decomposition of H2O2 and the oxidation of substrate TMB to oxTMB.
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PMC9429973
Results: AFM28 induced NK cell activation at low picomolar concentrations and mediated efficacious depletion of CD123 tumor cell lines and primary leukemic cells, including cells with low CD123 expression.
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PMC11770130
Afterward, the cells were maintained in a growth medium without insulin.
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PMC9927933
Protein ubiquitylation is a posttranslational modification that couples with the proteasome to form the ubiquitin-proteasome system (UPS).
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PMC9388315
As shown in Figure 2, bright spots that represented apoptosis in cells and irregular luminosity compared to control were seen.
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PMC11705630
To determine whether the increased ISGF3 components in GLDC deficient cells mediate cellular response to DNA damage, we knock-downed expressions of STAT2 and/or IRF9 in GLDC depleted ACHN cells treated with Dox/or CP.
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PMC10440586
Multiomics data were generated using these tumor tissue samples.
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PMC5963610
As a first anti-NGcGM3 therapy, we used the NGcGM3/VSSP vaccine which is quite immunogenic in mice and humans .
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PMC9878562
To extend the observation of DLBCL migration we measured mLEC transwell chemotaxis of DOHH2 cells in response to CXCL12.
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PMC11476222
Ganglioside standards GD1a, GD1b, GD2, GM1, GT1a were purchased from EMD Millipore Corp. (Billerica, MA, USA), and GM1d3 (internal standard) was purchased from Cayman Chemical (Ann Arbor, MI, USA).
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PMC11770130
The treatment of NTS also led to downregulation of body weight and fat mass in the obese mice (Supplementary information, Fig. S3i, j).
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PMC6889484
CD34 HSPCs from 3 donors were transduced with A3x3G(DK) vector virus or a control GFP lentiviral vector (LV-GFP) at an MOI of 20, and the proportion of fluorescent cells was determined by FACS 6 days post-transduction.
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PMC11564322
p < 0.001 vs. the respective peptide alone mRNA expression of NFKB2 and PPARγ genes in the leukemia cell lines.
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PMC11365427
Phenylalanine deprivation enhanced the recruitment of DR5 and caspase-8.
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PMC11756937
Cells were thawed by gentle twirling in 37°C.
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PMC11467800
Statistical significance is indicated as *p < 0.05; **p < 0.01 and ***p < 0.001; ns stands for non‐significant.
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PMC11740907
Following the treatment time, the cells were subjected to MTT and incubated in a light-restricted environment at a constant temperature of 37°C for a duration of 3–4 hr.
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PMC11489175
USP1 dependency has been related to the aberrant processing of mono- and poly-Ub PCNA in BRCA1/2 mutant tumors as well as in BRCA1/2 wild-type cell lines including ovarian cancer cells 83.
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PMC11347429
This approach allowed us to assign ethnicity based on genotyping rather than skin phenotype or questionnaires.
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PMC11739504
Primary cilia are indicated by white arrows.
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PMC11323699
Subsequently, subcutaneous tumors (black bar, SC model), peritoneal tumor masses, and metastatic nodules (pink and brown bars, respectively, IP model) were excised post euthanasia and then imaged for TAX2-Cy5 quantification.
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PMC11700247
Evaluation of the TME revealed that fewer endogenous T cells tended to infiltrate the spleen, as well as both irradiated and nonirradiated tumors, of the mice that were treated with the STING antagonist (supplemental Figure 5A-B).
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PMC11738017
These include (1) the membrane BCMA density, (2) the sBCMA levels, (3) the E:T ratio, and (4) the TCE concentration (Figure 7A).Figure 7.Schematic summary of the determinants of anti-BCMA TCE therapeutic response. (
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PMC11502962
Human-specific antibodies (CD206, Lot No: B318421 and CD86, Lot No: 0209406) were purchased from BD Biosciences.
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PMC10203589
Overall, FGF18 can function as an important oncogene at different gene and protein levels, and can be used as a potential new therapeutic target and prognostic biomarker for these tumors.
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PMC11593084
After lysing all cells with a buffer containing 0.5% Triton X-100, 10 mM Tris-HCl (pH 7.4), and 10 mM EDTA, cytotoxicity (% lysis) was determined using the formula % lysis = (E − S)/(M − S) × 100, where E represents the fluorescence of both target and effector cells, S is the spontaneous fluorescence of the target cell...
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PMC9780037
In one of these systems, cyt c-loaded pores are capped with smaller gold nanoparticles bound through electrostatic interactions.
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PMC4395774
Despite low levels of transduction (GFP expression < 10% with copy numbers of 3 for PGK.GFP, 2.5 for PGK.PRF, and 2 for PRF.PRF), almost full recovery of CD8 T-cell cytotoxicity (redirected killing of P815 cells conjugated with anti-CD3 antibody) was obtained with both vectors when normalized to the number of GFP-posit...
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PMC7642379
The presence of a truncated version of Large T in the 293E genome was confirmed by de novo assembly of all reads not mapping to the human reference genome (Supplementary Fig. S2).
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PMC11627133
Visualization by confocal microscopy and the observed colocalization of GFP and SpyRho fluorescence revealed successful targeting of synaptophysin‐GFP in neurites and cell soma as well as membrane‐bound GFP at the plasma membrane of neurons by AP3‐RhoBAST and SpyRho (Figure 1F, G, Figure S2B, C).
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PMC11488203
Fig. 8Effects of MSC taxol exosomes on breast cancer cells as compared to normal breast epithelial cells.
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PMC9429973
Aims: To report the final 5-y results assessing TFR maintenance after dasatinib discontinuation.
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PMC11802929
b GEX-UMAP, color-coded by phenotypes (top) and overlaid with the percentage of hydrophobic residues within CDR3βmer (HPhobic %) (bottom).
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PMC8751435
Lung cancer is the most ubiquitous malignant with highest incidence of cancer‐related death worldwide (Hirsch et al., 2017).
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PMC11490153
Identified compounds in C. citratus EO using GC-MS analysis are listed in Table 2.
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PMC11541241
The TSC1‐TSC2 functions as a GTPase activating protein (GAP) for the small GTPase Rheb (Ras homologue enhanced in the brain) (Huang & Manning, 2008; Nakashima & Tamanoi, 2010).
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PMC11790599
The formed macropinosomes rapidly mature, acquiring the characteristics of both early and late endosomes (RAB5 and RAB7).
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PMC11224020
The cell masks were created using the thresholding function in ImageJ. Subsequently, we duplicated the movie with the mask and applied the ‘skeletonize’ function in ImageJ. This function tags all the pixels/voxels in a skeleton image and then counts all junctions, triple and quadruple points and branches.
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PMC11726848
AnxV-FITC staining in the absence of PI staining corresponds to early apoptosis without compromising membrane integrity («PI-AnnV+»). «
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PMC11656657
Additionally, it fosters the long-term survival of tumor stem cells and contributes to the overall proliferation and migration of tumor cells .
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PMC10669966
We calculated the mean expression for each gene (excluding genes with <6 datapoints) per each healthy anatomical tissue type (n = 95) and per each cancerous tissue type (n = 106).
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PMC11745823
RIT1 knockdown inhibited colony formation and histogram analysis, n = 5. (
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PMC7519871
In this study, cytotoxicity of phytochemicals including wedelolactone (WDL), betulinic acid (BA) and epigallocatechin gallate (EGCG) was investigated in human cervical cancer cell line HeLa through 3-(4, 5-Dimethyl-2-thiazolyl)-2, 5-diphenyl-2H-tetrazolium bromide (MTT) reduction assay.
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PMC9841531
Pale yellow solid; yield: 71%; melting point: 190–192 °C: FTIR (cm): 3259.35 (NH), 2205.56 (CN), 1673.09 (C=O), 1572.50 (C=O), 1512.60 (C=C); H NMR (400 MHz, DMSO-d6) δ 10.56 (s, 1H), 8.63 (s, 1H), 8.54 (s, 1H), 7.99–7.95 (m, 1H), 7.57 (m, 3H), 7.30 (m, 2H), 7.16–7.10 (m, 2H), 5.30 (s, 2H), 3.81 (s, 3H); MS (m/z) calcu...
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PMC11675244
This effect was linked to β-catenin, as β-catenin knockdown decreases mTOR activity in cancer cells .
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PMC11474209
For instance, levels of 28 µg MC-LR/mL in New Zealand, 23.7 µg MCs/mL in South Africa, 13.6 µg MCs/mL in Uruguay, and 26.1 µg MCs/mL in Uruguay have been recorded .
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PMC11694346
Before evaluating the imaging capabilities of BT-DNBS, a cell viability assay was performed to assess its cytotoxicity using CCK-8.
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PMC10421378
Firstly, the bioreactors and equipment were prepared: the pH electrode was calibrated against buffers at pH 4 and pH 9; next, 1 L of MRS broth medium was added to the vessel and then the bioreactor was autoclaved at 121 °C with a 20 min exposure time to provide sterile conditions.
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PMC11301242
By analyzing Hi-C data from the HL60 cell line, we detected chromatin neo-loops in areas overlapping with the circular amplification regions.
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PMC11665555
Interestingly, PPARG is among the unique OVOL1 targets.
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PMC11352746
Another problem that we faced involved the viability indicator DRAQ5.
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PMC6892818
We studied renal cell carcinoma (RCC) in comparison to normal (human renal proximal tubule) cells, as a model to better understand the role of CD40 in epithelial cells.
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PMC7812570
As shown in Fig. 1B, both of the transgenes were efficiently expressed on the surface of transduced cells, but their expression greatly decreased after PI-PLC treatment, confirming that the m36.4 and FluIg03 antibodies were tethered to the cell membrane through a GPI anchor.
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PMC11754784
g Time and distance-dependent simulation of concentration changes of DNA strand caused by diffusion.
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PMC10344560
We planned oral itraconazole 200 mg per day for 3 months based on the antifungal resistance test.
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PMC9429973
Supporting these results, the data obtained from the CoMMpass project showed the MM patients (N= 793) with higher expression of CD155 had shorter overall survival than lower expressing ones (p<0.001).
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