OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11487720	M–O, Two identical MDA-MB-231 cell lines (original and NH) and a metastatic line (IV-2–3) were treated similarly with UV and/or cold shock under different temperatures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "...
PMC11448304	b Bar plot and (c) volcano plot of significantly differentially modified proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "b", "Bar", "plot", "and", "(", "c", ")", "volcano", "plot"...
PMC10482220	Given that the RRM of G3BP alone induced only weak SG formation (Fig. 2 A), both oligomerization and the RRM domain of G3BP appear to be required for efficient recruitment and SG formation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742431	The highest inhibition rate was observed in 5637 cells, followed by UMUC‐3 cells, and no inhibition in A375 cells (Figure 5B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O"...
PMC11335267	Image analysis was carried out using NIH ImageJ. For each animal, the total fat volume was calculated and converted to grams by assuming a density of adipose tissue of 0.9 g/ml .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10178190	Relative to reference dots densitometry of the various dots in the two filters, the correlates to CM of HS-5 and TA HS-5 were calculated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11536589	The protein levels of MGST1 in AsPC1-MR cells transfected with different RNA interference (RNAi) molecules.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "protein", "levels", "of", "MGST1"...
PMC11796104	From the constructed ceRNA network, circRNAs with significant differences in osteoporosis patients and the miRNA with the highest coverage were selected for validation in clinical samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11635087	The CHO-K1 cell culture supernatant was removed, and the chloroplast solution was resuspended and seeded onto the culture medium containing CHO-K1 cells.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens"...
PMC6627640	This highlights the complex role of polycomb in tumorigenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "highlights", "the", "complex", "role", "of", "polycomb", "in", "tumorigenesis", "." ] } ]
PMC9429973	Overall survival (OS) and cancer-specific survival (CSS) curves were explored using the Kaplan-Meier method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overall", "survival", "(", "OS", ")", ...
PMC10873328	Furthermore, the high-risk group had higher percentage of Macrophages M2 and exhibited higher expression of immunecheckpoints such as PD-L2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "the", ...
PMC6803987	In addition, on the fifth day after treatment, the rebound of HBeAg secretion in esculetin-treated ducks was less than that in the 3TC treatment group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10588957	These findings indicate that DATS could promote autophagy in HepG2 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "These", "findings", "indicate", "that", "DATS", "could", "promote", "autophagy", "...
PMC8540692	The analysis of the cell cycle distribution revealed that the observed effects are also cell line-dependent.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "analysis", "of", "the", "cell", "cycle", ...
PMC11474209	Algal blooms are a serious menace to freshwater bodies all over the world.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Algal", "blooms", "are", "a", "serious", "menace", "to", "freshwater", ...
PMC11628904	Wound colonisation was distinguished based on the presence of C. albicans at the interface between viable and nonviable tissue. ,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Wound", "colonisation", "was...
PMC10165258	Values of the FIC indicate that the drugs are antagonistic, whereas values of FIC indicate synergy between the drugs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Values", "of", "the", ...
PMC11621493	The x-axis shows the log2 (fold change) of the indicated phospholipid subspecies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "x-axis", "shows", "the", "log2", "(", "fold", "change", ...
PMC11786156	We also measured the extravascular and intravascular intercellular distances of DLBCL cells as indicators of the tumor microenvironment (TME).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "mea...
PMC5673060	Ontology analysis of these phosphorylated proteins identified an enrichment of proteins involved in transcription regulation including the ontology terms “transcription regulation”, “transcription”, “transcription activator” and “transcription repressor” (Figs. 2C and 3A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8875242	The antiretrovirals atazanavir (50 µM), darunavir (100 µM), lopinavir (50 µM), rilpivirine (20 µM), ritonavir (50 µM), and saquinavir (20 µM), as well as the DAAs asunaprevir (50 µM), daclatasvir (20 µM), and grazoprevir (50 µM), all reduced the rPapp of [H]-digoxin to values in the range of 1.11 to 1.91, making their ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11476106	This has prompted researchers to develop alternatives for new therapies, including mechanotherapies, aimed at modulating mechanical forces, for example, by disrupting communication between tumor cells and ECM components and thus inhibiting migration .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3164356	Different chromosomal counts have been reported for the CHO-K1 karyotype, presumably due to its genomic instability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Different", "chromosomal", "counts", "have", ...
PMC11777207	Following staining, the cells were washed and run on the cytometer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Following", "staining", ",", "the", "cells", "were", "washed", "and", "run", ...
PMC11078693	CRITICAL: A small amount of conjugated antibodies will attach to the poly-lysine at glass surface, staining it weakly (Video S1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11265931	This suggests that the nanovesicles play a role in inducing apoptosis and inhibiting the proliferation of cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "suggests", "that", "the", "nan...
PMC11761919	All animal experiments were performed in the Veterinary Hospital of Northeast Agricultural University, China.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "animal", "experiments", "were", "performed", "in", "...
PMC11726848	The cells positively stained with Annexin V were considered to be the cells with the presence of phosphatidylserine on the outer side of the membrane.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11759543	Approximately 70 % of bladder cancers are diagnosed as non-muscle invasive, and they are treated with transurethral resection followed by intravesical therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Approxi...
PMC8409415	Subsequently, the western blotting (WB) samples were incubated with donkey anti‐goat horseradish peroxidase (HRP)‐conjugated secondary antibodies (1:10 000, sc‐2020; Santa Cruz Biotechnology).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9220170	Similar to SELENOM-KD, downregulation of SELENOT mRNA in A-172 cells did not significantly affect the expression of ER stress markers (Figure 6b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ],...
PMC7504302	The knockdown of WT1 (Wilms Tumor Protein 1), another transcription factor highly expressed in MPM, greatly reduced the proliferation, chemotaxis, and invasion of MPM cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8711270	The HEK293 cell line was established by transforming human embryonic kidney cells with sheared adenovirus type 5 DNA (Graham et al., 1977).	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ],...
PMC11623887	For flowcytometry analysis, 50×10 cells from each group were transferred into 2 ml microtubes with 100 µl phosphate-buffered saline (PBS, Sigma) with 0.5% BSA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11697065	Principal component analysis (PCA) was performed on transcriptomic and proteomic data sets (Fig. 2B) but revealed no clear separation of ETE and DTE cell pools.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", ...
PMC9424261	We also tested whether the binding between GSS and the two ubiquitinases changed following HERPUD1 overexpression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "tested", "whether", "the", "binding", ...
PMC11767582	This reaction took place in moderate to good yields (Table 1) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "reaction", "took", "place", "in", "moderate", "to", "good", "...
PMC11225860	After release from the thymidine block, DMSO treated cells decrease G1 population and increase S-G2 population up until division at 12 hours.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After",...
PMC11365427	Tumor nodules in NOG mice injected with NCI-H929 cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Tumor", "nodules", "in", "NOG", "mice", "injected", "with", "NCI-H929", "cells", ".", ...
PMC11633763	Research evidence indicates that the activation of the Wnt/β‐catenin pathway is involved in tumour and nontumor disorders, including tumour metabolism, immunity, growth and metastasis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Majority of patients were female (71/114 (62.3%)).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Majority", "of", "patients", "were", "female", "(", "71/114", "(", "62.3", ...
PMC11476264	It is noteworthy that the protein expression of Snail and Slug did not change (Figure 1A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "noteworthy", "that", "the"...
PMC11267830	Therefore, we speculate that the resistance mechanism in HUT78 and 6T-CEM cells is due to the aberrant splicing of effector genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "...
PMC11377827	Source data are available online for this figure. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Source", "data", "are", "available", "online", "for", "this", "figure", ".", "(" ] } ]
PMC3203927	The LDA results are presented in Table 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "LDA", "results", "are", "presented", "in", "Table", "1", "." ] } ]
PMC5925824	Allogeneic DC were co-cultured with purified CD4 T cells for 72 h in the presence of increasing (two-fold increments) concentrations of LY3300054, ipilimumab or a combination of both antibodies ranging from 0.0003 to 67 nM. Supernatants were measured for IFN-γ and IL-2 production by ELISA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594074	In normal cells, DNA methylation and demethylation are tightly regulated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "normal", "cells", ",", "DNA", "methylation", "and", "demethylation", "are", "ti...
PMC7039683	Using gkmSVM, a SNP’s impact on the score of a 19-base-pair (bp) element encompassing it is called its deltaSVM: SNPs that convert strongly-weighted (i.e., enriched or depleted) 10mers into unweighted ones will have large deltaSVM values (Lee et al., 2015).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11585565	For (b) and (c), individual data points are presented with means and standard errors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "(", "b", ")", "and",...
PMC11098378	Membranes were blotted with primary antibody overnight at 4°C, with actin serving as a loading control unless otherwise stated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Membranes", ...
PMC9429973	Structural (del(5q), del(7q), rearrangements of 3q, 12p, 17p and 11q23, t(8;21)(q22;q22), t(9;22)(q34;q11), t(15;17)(q22;q21), t(16;16)(p13;q22), inv(16)(p13q22), marker and ring chromosomes, acentric structures and others) and numerical (-5, -7, -Y, +8, monosomal karyotype and others) chromosomal abnormalities in leuk...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9822769	Today, systemic anticancer treatment is oriented towards targeted and immune therapy, with the aim of achieving precision medicine .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Today", ",", "systemic", ...
PMC8336407	Our results showed that the extract suppresses the lipid peroxidation more effectively at 1.5 and 2.0 mg/mL concentrations (Table 4).Table 1The effect of pyrus biossieriana buhse leaf extract and t-BHP treatment on the cell viability of HepG2 cell lineControl100.0 ± 1.10p valuet10072.86 ± 2.10p valuet15063.82 ± 1.7p va...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: Overall, 24 patients enrolled and 22 finished Part A and entered Part B, with 19 (86.4%) patients completing Part B. The mean (SD) FACIT-Fatigue score at baseline was 32 (11) and improved by 7 (8) within 1 week of sutimlimab treatment; the mean change score from baseline remained ≥5 from Week 1 to Week 135 (mi...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: To evaluate efficacy and safety of Zanubrutinib, rituximab, methotrexate and cytarabine(ZRMA regimen) in patients with primary CNS diffuse large b cell lymphoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11726848	The effect of ionizing radiation on cells is mainly determined by the superposition of the direct and indirect (free radical-induced) damage of DNA and DNA repair mechanisms , and depends significantly on the particle fluence per unit time, which leads to the occurrence of dose rate effects .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11738017	In this study, we investigated the mechanisms involved in mediating primary resistance to anti-BCMA TCEs and identified 4 variables that cumulatively accounted for their cytolytic activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742670	Ideally, the model would be fully transparent, but in many cases in DL models, there is a certain degree of explainability, which can be likened to the “glass box” with an opacity degree between 0% and 100%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4395774	For this vector, a fragment of this promoter was used consisting of 1.3 Kb DNA upstream of the human perforin gene, which contains the basal core promoter (−244 bp), for expression in effector cells and two elements at −350 and −650 bp that repress transcriptional activity in noneffector cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11024707	This value is generally named cycle threshold.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "value", "is", "generally", "named", "cycle", "threshold", "." ] } ]
PMC11757230	The original contributions presented in the study are included in the article.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "original", "contributions", "presented", "in", "the", "study", "are", "in...
PMC9429973	M. K. Blum, S. V. Hansen, O. Cédile, J. Haaber, L. Chen, M. Kassem, N. Abildgaard, M. H. Hansen, C. G. Nyvold Hematology-Pathology Research Laboratory, Research Unit for Hematology and Research Unit for Pathology, University of Sothern Denmark and Odense University Hospital; OPEN, Odense Patient data Explorative Networ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Despite the use of targeted NGS, almost half of the cases remained idiopathic.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Despite", "the", "use", "of", "targeted", "NGS", ",", "almost", ...
PMC11574029	To generate stable cell lines, lentiviral particles for NOTCH3 knockdown and SPP1 overexpression were obtained from GeneChem.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "generate", "stable", "cell", "li...
PMC10291556	Additionally, an essential feature of ICD is that ICD inducers should also increase tumor cell phagocytosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "an", "essential", "feature",...
PMC9429973	Summary/Conclusion: The result of this study confirms the result of two previous studies in the same center which encourages the successful management of ITP by observation only and support the consensus that ITP is a benign and self-limited condition for the majority of affected children.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7709199	IL-12B appears to contain two major glycan populations when produced in HEK293T cells, while only a single band is visible in GD-derived IL-12B.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11739484	Providing an intuitive interface, cBioPortal enables researchers to interactively analyze and visualize multifaceted cancer datasets, incorporating genetic mutations and clinical information.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Providi...
PMC11594074	When developing novel anticancer agents, it is crucial that these agents display cytostatic effects by inhibiting factors that are otherwise advantageous to cancer cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10523483	Here, we showed a mechanism by which H1.2 deficiency decreased the enrichment of NRF2 in nucleus and in ARE regions within GCLC promoter and subsequently down-regulated GCLC transcription (Figs. 4 D–G and 5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11650848	Furthermore, the significant role that the mQTL (rs365052) plays in driving cis methylation can lead to altered expression of the ZFP57 gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11026382	Further study of enzyme rates and abundance across species, as well as characterizations of enzyme velocity to growth rate mappings, will help shape our understanding of the system level constraints placed on metabolic enzymes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754094	After fragmentation to ~300 bp, the fragmented DNA is sequenced by Illumina.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "fragmentation", "to", "~300", "bp", ",", "the", "fragmented", ...
PMC9429973	Up to 30 additional pts in MMR at baseline and intolerant to their most recent TKI treatment will also be enrolled; these pts will not be part of the primary endpoint analysis; however all assessments will be performed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11777207	However, simultaneous treatment of mice with PD-L1 and CTLA-4 antibodies allows for restored expression of CD80 on tumor-associated DCs, leading to increased CD28 costimulation, downstream T cell responses, and reduced overall tumor burden (6, 72, 73).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3164356	A genome-scale analysis of the glycosylation genes in the CHO-K1 genome identifies homologs to 99% of the human glycosylation-associated transcripts, with 53% of them expressed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10887351	Interestingly, in BC, it has been reported the presence of both β3-AR mRNA and protein, and it has been studied the correlation with the β3-AR polymorphism Trp64Arg that has shown an increased susceptibility to endometrial cancer and a decreased risk of BC, specifically when associated with the Gln27Glu polymorphism in...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6892818	GM-CSF is a pleiotropic cytokine that enhances recruitment of neutrophils and macrophages towards tumours and assists in tumour cell lysis via macrophages and dendritic cells (DC); therefore, GM-CSF release concomitantly with mCD40L-mediated apoptosis may be of therapeutic value.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	No DLTs were observed in the HR or LR groups and 160mg BID days 1-14 of 28 days was deemed the RP2D.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11754784	Red: mixed cancer cells; blue: lymphocytes and granulocytes in human blood samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Red", ":", "mixed", "cancer", "cells", ";", "blue", "...
PMC9817179	However, when one fixation rate is faster than the other, we observe a bifurcating effect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "when", "one", "fixation", "...
PMC10719213	Equal protein concentrations were separated by Tris-glycine SDS-PAGE and transferred to nitrocellulose by semi-dry transfer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Equal", "protein", "concentrations", "were", "separated", "by", ...
PMC11805741	The structure analysis between BCL-2 protein and zeaxanthin revealed two significant interactions characterized by their van der Waals overlaps and distances.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "structure", ...
PMC11578343	We thus speculate that so too HMECs with BRCA2 or PALB2 or even HMECS from women who are high risk but have no identifiable germline mutation may also have similar viscoelasticity as the BRCA1 cells we measured here.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11463018	H NMR (400 MHz, DMSO-d6) δ: 11.14 (s, 1H), 8.98 (s, 1H), 7.71 − 7.66 (m, 2H), 7.58 − 7.55 (m, 1H), 7.54 − 7.43 (m, 3H), 7.43 − 7.38 (m, 3H), 7.34 − 7.29 (m, 1H), 7.11 − 7.05 (m, 2H), 4.47 (d, J = 6.3 Hz, 2H), 3.77 (s, 3H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7723249	The ethical committee at the Karolinska Institutet approved our studies involving human samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ethical", "committee", "at", "the", "Karolinska", "Institutet", "app...
PMC11248911	HNMR (DMSO-d6, δ ppm): 2.18 (s, 3H, CH3), 2.95–3.01 (dd, 1H, pyrazoline, J = 4.00, 18.60 Hz), 3.75–3.83 (dd, 1H, pyrazoline, J = 11.08, 18.60 Hz), 3.83 (s, 3H, OCH3), 5.70–5.74 (dd, 1H, pyrazoline, J = 4.08, 11.08 Hz), 7.09–7.81 (m, 10H, Ar–H and CH-benzylidene).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11593713	The correct assessment includes the calculation of the oxidative stress index (OSI), which measures both total oxidant status (TOS) and total antioxidant capacity (TAC) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11544122	A phospho-peptide derived from the C-terminus of the V2 vasopressin receptor, known as V2Rpp (Supplementary Fig. S11b), did not bind to SNX9 (Fig. 6d), consistent with endocytosis of the V2 vasopressin receptor being SNX9-independent (Fig. 4b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8973725	Overexpression of ZNF677 induced 786–0 cell apoptosis.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Overexpression", "of", "ZNF677", "induced", "786–0", "cell", "apoptosis", "." ] } ]
PMC11705862	Hence, a loss of CD59 may have detrimental effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hence", ",", "a", "loss", "of", "CD59", "may", "have", "detrimental", "effects", "." ]...
PMC9429973	A significant number of IE patients displayed TFR2 mutations, giving more relevance to the hypothesis of the iron metabolism implication in IE genesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Infrequently CLPD-NK can present with several non-indolent features, potentially mimicking more aggressive clinical entities (such as aggressive NK cell leukemia).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Infrequ...
PMC10048572	Five out of 6 (83%) of the studied patients had differences in clonal rearrangements at onset and relapse, which indicates the instability of clones during polychemotherapy, i.e., a probable chemo-induced clonal evolution .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721277	In the initial phase of the synthesis process (Scheme 1), the vinyl group of pyrrole A underwent oxidation, resulting in the formation of a carboxylic group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11768927	Natural agents, like curcumin, have also displayed a beneficial effect when combined with rVSV.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Natural", "agents", ",", "like", "curcumin", ",", ...
PMC11727306	The GFP assay was performed as follows.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "GFP", "assay", "was", "performed", "as", "follows", "." ] } ]
PMC11783017	Statistical analysis was performed using Student's t-test (two-tailed) and one-way analysis of variance (ANOVA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "analysis", "was", ...
PMC11541409	SDH-deficient GISTs, accounting for less than 9% of all cases, represent the third most common GIST subtype .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SDH-deficient", "GISTs", ","...

PMC11487720

M–O, Two identical MDA-MB-231 cell lines (original and NH) and a metastatic line (IV-2–3) were treated similarly with UV and/or cold shock under different temperatures.

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PMC11448304

b Bar plot and (c) volcano plot of significantly differentially modified proteins.

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PMC10482220

Given that the RRM of G3BP alone induced only weak SG formation (Fig. 2 A), both oligomerization and the RRM domain of G3BP appear to be required for efficient recruitment and SG formation.

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PMC11742431

The highest inhibition rate was observed in 5637 cells, followed by UMUC‐3 cells, and no inhibition in A375 cells (Figure 5B).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O"...

PMC11335267

Image analysis was carried out using NIH ImageJ. For each animal, the total fat volume was calculated and converted to grams by assuming a density of adipose tissue of 0.9 g/ml .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10178190

Relative to reference dots densitometry of the various dots in the two filters, the correlates to CM of HS-5 and TA HS-5 were calculated.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11536589

The protein levels of MGST1 in AsPC1-MR cells transfected with different RNA interference (RNAi) molecules.

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PMC11796104

From the constructed ceRNA network, circRNAs with significant differences in osteoporosis patients and the miRNA with the highest coverage were selected for validation in clinical samples.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11635087

The CHO-K1 cell culture supernatant was removed, and the chloroplast solution was resuspended and seeded onto the culture medium containing CHO-K1 cells.

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PMC6627640

This highlights the complex role of polycomb in tumorigenesis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "highlights", "the", "complex", "role", "of", "polycomb", "in", "tumorigenesis", "." ] } ]

PMC9429973

Overall survival (OS) and cancer-specific survival (CSS) curves were explored using the Kaplan-Meier method.

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PMC10873328

Furthermore, the high-risk group had higher percentage of Macrophages M2 and exhibited higher expression of immunecheckpoints such as PD-L2.

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PMC6803987

In addition, on the fifth day after treatment, the rebound of HBeAg secretion in esculetin-treated ducks was less than that in the 3TC treatment group.

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PMC10588957

These findings indicate that DATS could promote autophagy in HepG2 cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "These", "findings", "indicate", "that", "DATS", "could", "promote", "autophagy", "...

PMC8540692

The analysis of the cell cycle distribution revealed that the observed effects are also cell line-dependent.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "analysis", "of", "the", "cell", "cycle", ...

PMC11474209

Algal blooms are a serious menace to freshwater bodies all over the world.

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PMC11628904

Wound colonisation was distinguished based on the presence of C. albicans at the interface between viable and nonviable tissue. ,

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PMC10165258

Values of the FIC indicate that the drugs are antagonistic, whereas values of FIC indicate synergy between the drugs.

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PMC11621493

The x-axis shows the log2 (fold change) of the indicated phospholipid subspecies.

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PMC11786156

We also measured the extravascular and intravascular intercellular distances of DLBCL cells as indicators of the tumor microenvironment (TME).

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PMC5673060

Ontology analysis of these phosphorylated proteins identified an enrichment of proteins involved in transcription regulation including the ontology terms “transcription regulation”, “transcription”, “transcription activator” and “transcription repressor” (Figs. 2C and 3A).

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PMC8875242

The antiretrovirals atazanavir (50 µM), darunavir (100 µM), lopinavir (50 µM), rilpivirine (20 µM), ritonavir (50 µM), and saquinavir (20 µM), as well as the DAAs asunaprevir (50 µM), daclatasvir (20 µM), and grazoprevir (50 µM), all reduced the rPapp of [H]-digoxin to values in the range of 1.11 to 1.91, making their ...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11476106

This has prompted researchers to develop alternatives for new therapies, including mechanotherapies, aimed at modulating mechanical forces, for example, by disrupting communication between tumor cells and ECM components and thus inhibiting migration .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC3164356

Different chromosomal counts have been reported for the CHO-K1 karyotype, presumably due to its genomic instability.

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PMC11777207

Following staining, the cells were washed and run on the cytometer.

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PMC11078693

CRITICAL: A small amount of conjugated antibodies will attach to the poly-lysine at glass surface, staining it weakly (Video S1).

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PMC11265931

This suggests that the nanovesicles play a role in inducing apoptosis and inhibiting the proliferation of cancer cells.

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PMC11761919

All animal experiments were performed in the Veterinary Hospital of Northeast Agricultural University, China.

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PMC11726848

The cells positively stained with Annexin V were considered to be the cells with the presence of phosphatidylserine on the outer side of the membrane.

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PMC11759543

Approximately 70 % of bladder cancers are diagnosed as non-muscle invasive, and they are treated with transurethral resection followed by intravesical therapy.

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PMC8409415

Subsequently, the western blotting (WB) samples were incubated with donkey anti‐goat horseradish peroxidase (HRP)‐conjugated secondary antibodies (1:10 000, sc‐2020; Santa Cruz Biotechnology).

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PMC9220170

Similar to SELENOM-KD, downregulation of SELENOT mRNA in A-172 cells did not significantly affect the expression of ER stress markers (Figure 6b).

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PMC7504302

The knockdown of WT1 (Wilms Tumor Protein 1), another transcription factor highly expressed in MPM, greatly reduced the proliferation, chemotaxis, and invasion of MPM cells.

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PMC8711270

The HEK293 cell line was established by transforming human embryonic kidney cells with sheared adenovirus type 5 DNA (Graham et al., 1977).

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PMC11623887

For flowcytometry analysis, 50×10 cells from each group were transferred into 2 ml microtubes with 100 µl phosphate-buffered saline (PBS, Sigma) with 0.5% BSA.

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PMC11697065

Principal component analysis (PCA) was performed on transcriptomic and proteomic data sets (Fig. 2B) but revealed no clear separation of ETE and DTE cell pools.

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PMC9424261

We also tested whether the binding between GSS and the two ubiquitinases changed following HERPUD1 overexpression.

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PMC11767582

This reaction took place in moderate to good yields (Table 1) .

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PMC11225860

After release from the thymidine block, DMSO treated cells decrease G1 population and increase S-G2 population up until division at 12 hours.

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PMC11365427

Tumor nodules in NOG mice injected with NCI-H929 cells. (

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PMC11633763

Research evidence indicates that the activation of the Wnt/β‐catenin pathway is involved in tumour and nontumor disorders, including tumour metabolism, immunity, growth and metastasis .

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PMC9429973

Majority of patients were female (71/114 (62.3%)).

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PMC11476264

It is noteworthy that the protein expression of Snail and Slug did not change (Figure 1A).

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PMC11267830

Therefore, we speculate that the resistance mechanism in HUT78 and 6T-CEM cells is due to the aberrant splicing of effector genes.

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PMC11377827

Source data are available online for this figure. (

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PMC3203927

The LDA results are presented in Table 1.

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PMC5925824

Allogeneic DC were co-cultured with purified CD4 T cells for 72 h in the presence of increasing (two-fold increments) concentrations of LY3300054, ipilimumab or a combination of both antibodies ranging from 0.0003 to 67 nM. Supernatants were measured for IFN-γ and IL-2 production by ELISA.

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PMC11594074

In normal cells, DNA methylation and demethylation are tightly regulated.

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PMC7039683

Using gkmSVM, a SNP’s impact on the score of a 19-base-pair (bp) element encompassing it is called its deltaSVM: SNPs that convert strongly-weighted (i.e., enriched or depleted) 10mers into unweighted ones will have large deltaSVM values (Lee et al., 2015).

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PMC11585565

For (b) and (c), individual data points are presented with means and standard errors.

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PMC11098378

Membranes were blotted with primary antibody overnight at 4°C, with actin serving as a loading control unless otherwise stated.

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PMC9429973

Structural (del(5q), del(7q), rearrangements of 3q, 12p, 17p and 11q23, t(8;21)(q22;q22), t(9;22)(q34;q11), t(15;17)(q22;q21), t(16;16)(p13;q22), inv(16)(p13q22), marker and ring chromosomes, acentric structures and others) and numerical (-5, -7, -Y, +8, monosomal karyotype and others) chromosomal abnormalities in leuk...

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PMC9822769

Today, systemic anticancer treatment is oriented towards targeted and immune therapy, with the aim of achieving precision medicine .

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PMC8336407

Our results showed that the extract suppresses the lipid peroxidation more effectively at 1.5 and 2.0 mg/mL concentrations (Table 4).Table 1The effect of pyrus biossieriana buhse leaf extract and t-BHP treatment on the cell viability of HepG2 cell lineControl100.0 ± 1.10p valuet10072.86 ± 2.10p valuet15063.82 ± 1.7p va...

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PMC9429973

Results: Overall, 24 patients enrolled and 22 finished Part A and entered Part B, with 19 (86.4%) patients completing Part B. The mean (SD) FACIT-Fatigue score at baseline was 32 (11) and improved by 7 (8) within 1 week of sutimlimab treatment; the mean change score from baseline remained ≥5 from Week 1 to Week 135 (mi...

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PMC9429973

Aims: To evaluate efficacy and safety of Zanubrutinib, rituximab, methotrexate and cytarabine(ZRMA regimen) in patients with primary CNS diffuse large b cell lymphoma.

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PMC11726848

The effect of ionizing radiation on cells is mainly determined by the superposition of the direct and indirect (free radical-induced) damage of DNA and DNA repair mechanisms , and depends significantly on the particle fluence per unit time, which leads to the occurrence of dose rate effects .

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PMC11738017

In this study, we investigated the mechanisms involved in mediating primary resistance to anti-BCMA TCEs and identified 4 variables that cumulatively accounted for their cytolytic activity.

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PMC11742670

Ideally, the model would be fully transparent, but in many cases in DL models, there is a certain degree of explainability, which can be likened to the “glass box” with an opacity degree between 0% and 100%.

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PMC4395774

For this vector, a fragment of this promoter was used consisting of 1.3 Kb DNA upstream of the human perforin gene, which contains the basal core promoter (−244 bp), for expression in effector cells and two elements at −350 and −650 bp that repress transcriptional activity in noneffector cells.

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PMC11024707

This value is generally named cycle threshold.

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PMC11757230

The original contributions presented in the study are included in the article.

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PMC9429973

M. K. Blum, S. V. Hansen, O. Cédile, J. Haaber, L. Chen, M. Kassem, N. Abildgaard, M. H. Hansen, C. G. Nyvold Hematology-Pathology Research Laboratory, Research Unit for Hematology and Research Unit for Pathology, University of Sothern Denmark and Odense University Hospital; OPEN, Odense Patient data Explorative Networ...

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PMC9429973

Despite the use of targeted NGS, almost half of the cases remained idiopathic.

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PMC11574029

To generate stable cell lines, lentiviral particles for NOTCH3 knockdown and SPP1 overexpression were obtained from GeneChem.

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PMC10291556

Additionally, an essential feature of ICD is that ICD inducers should also increase tumor cell phagocytosis.

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PMC9429973

Summary/Conclusion: The result of this study confirms the result of two previous studies in the same center which encourages the successful management of ITP by observation only and support the consensus that ITP is a benign and self-limited condition for the majority of affected children.

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PMC7709199

IL-12B appears to contain two major glycan populations when produced in HEK293T cells, while only a single band is visible in GD-derived IL-12B.

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PMC11739484

Providing an intuitive interface, cBioPortal enables researchers to interactively analyze and visualize multifaceted cancer datasets, incorporating genetic mutations and clinical information.

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PMC11594074

When developing novel anticancer agents, it is crucial that these agents display cytostatic effects by inhibiting factors that are otherwise advantageous to cancer cells .

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PMC10523483

Here, we showed a mechanism by which H1.2 deficiency decreased the enrichment of NRF2 in nucleus and in ARE regions within GCLC promoter and subsequently down-regulated GCLC transcription (Figs. 4 D–G and 5).

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PMC11650848

Furthermore, the significant role that the mQTL (rs365052) plays in driving cis methylation can lead to altered expression of the ZFP57 gene.

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PMC11026382

Further study of enzyme rates and abundance across species, as well as characterizations of enzyme velocity to growth rate mappings, will help shape our understanding of the system level constraints placed on metabolic enzymes.

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PMC11754094

After fragmentation to ~300 bp, the fragmented DNA is sequenced by Illumina.

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PMC9429973

Up to 30 additional pts in MMR at baseline and intolerant to their most recent TKI treatment will also be enrolled; these pts will not be part of the primary endpoint analysis; however all assessments will be performed.

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PMC11777207

However, simultaneous treatment of mice with PD-L1 and CTLA-4 antibodies allows for restored expression of CD80 on tumor-associated DCs, leading to increased CD28 costimulation, downstream T cell responses, and reduced overall tumor burden (6, 72, 73).

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PMC3164356

A genome-scale analysis of the glycosylation genes in the CHO-K1 genome identifies homologs to 99% of the human glycosylation-associated transcripts, with 53% of them expressed.

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PMC10887351

Interestingly, in BC, it has been reported the presence of both β3-AR mRNA and protein, and it has been studied the correlation with the β3-AR polymorphism Trp64Arg that has shown an increased susceptibility to endometrial cancer and a decreased risk of BC, specifically when associated with the Gln27Glu polymorphism in...

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PMC6892818

GM-CSF is a pleiotropic cytokine that enhances recruitment of neutrophils and macrophages towards tumours and assists in tumour cell lysis via macrophages and dendritic cells (DC); therefore, GM-CSF release concomitantly with mCD40L-mediated apoptosis may be of therapeutic value.

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PMC9429973

No DLTs were observed in the HR or LR groups and 160mg BID days 1-14 of 28 days was deemed the RP2D.

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PMC11754784

Red: mixed cancer cells; blue: lymphocytes and granulocytes in human blood samples.

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PMC9817179

However, when one fixation rate is faster than the other, we observe a bifurcating effect.

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PMC10719213

Equal protein concentrations were separated by Tris-glycine SDS-PAGE and transferred to nitrocellulose by semi-dry transfer.

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PMC11805741

The structure analysis between BCL-2 protein and zeaxanthin revealed two significant interactions characterized by their van der Waals overlaps and distances.

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PMC11578343

We thus speculate that so too HMECs with BRCA2 or PALB2 or even HMECS from women who are high risk but have no identifiable germline mutation may also have similar viscoelasticity as the BRCA1 cells we measured here.

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PMC11463018

H NMR (400 MHz, DMSO-d6) δ: 11.14 (s, 1H), 8.98 (s, 1H), 7.71 − 7.66 (m, 2H), 7.58 − 7.55 (m, 1H), 7.54 − 7.43 (m, 3H), 7.43 − 7.38 (m, 3H), 7.34 − 7.29 (m, 1H), 7.11 − 7.05 (m, 2H), 4.47 (d, J = 6.3 Hz, 2H), 3.77 (s, 3H).

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PMC7723249

The ethical committee at the Karolinska Institutet approved our studies involving human samples.

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PMC11248911

HNMR (DMSO-d6, δ ppm): 2.18 (s, 3H, CH3), 2.95–3.01 (dd, 1H, pyrazoline, J = 4.00, 18.60 Hz), 3.75–3.83 (dd, 1H, pyrazoline, J = 11.08, 18.60 Hz), 3.83 (s, 3H, OCH3), 5.70–5.74 (dd, 1H, pyrazoline, J = 4.08, 11.08 Hz), 7.09–7.81 (m, 10H, Ar–H and CH-benzylidene).

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PMC11593713

The correct assessment includes the calculation of the oxidative stress index (OSI), which measures both total oxidant status (TOS) and total antioxidant capacity (TAC) .

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PMC11544122

A phospho-peptide derived from the C-terminus of the V2 vasopressin receptor, known as V2Rpp (Supplementary Fig. S11b), did not bind to SNX9 (Fig. 6d), consistent with endocytosis of the V2 vasopressin receptor being SNX9-independent (Fig. 4b).

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PMC8973725

Overexpression of ZNF677 induced 786–0 cell apoptosis.

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PMC11705862

Hence, a loss of CD59 may have detrimental effects.

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PMC9429973

A significant number of IE patients displayed TFR2 mutations, giving more relevance to the hypothesis of the iron metabolism implication in IE genesis.

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PMC9429973

Infrequently CLPD-NK can present with several non-indolent features, potentially mimicking more aggressive clinical entities (such as aggressive NK cell leukemia).

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PMC10048572

Five out of 6 (83%) of the studied patients had differences in clonal rearrangements at onset and relapse, which indicates the instability of clones during polychemotherapy, i.e., a probable chemo-induced clonal evolution .

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PMC11721277

In the initial phase of the synthesis process (Scheme 1), the vinyl group of pyrrole A underwent oxidation, resulting in the formation of a carboxylic group.

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PMC11768927

Natural agents, like curcumin, have also displayed a beneficial effect when combined with rVSV.

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PMC11727306

The GFP assay was performed as follows.

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PMC11783017

Statistical analysis was performed using Student's t-test (two-tailed) and one-way analysis of variance (ANOVA).

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PMC11541409

SDH-deficient GISTs, accounting for less than 9% of all cases, represent the third most common GIST subtype .

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