OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC9119314	After the microplates were thawed, 100 μL from each well was transferred into a duplicate plate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "the", "microplates", "were", "thawed", ...
PMC11745600	However, mice with STZ-induced diabetes exhibit considerable interindividual variation in blood glucose levels, and it is noteworthy that these mice occasionally demonstrate a restoration of their endogenous pancreatic β cells, which causes difficulty in interpretation when assessing the efficacy of cell transplantatio...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6742971	To determine the cytokine production by the CD8 T cell clones with different functional avidities, we performed IFN-γ Elispot assays, a well-suited method to compare T cell functions of different clones alone, as well as after mixing them in defined ratios (3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11279397	The annual herb Perilla frutescens (L.) Britt.,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "annual", "herb", "Perilla", "frutescens", "(", "L.", ")", "Britt", ".", "," ] ...
PMC10440586	Cox-analysis of eight different datasets.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cox-analysis", "of", "eight", "different", "datasets", "." ] } ]
PMC9429973	The 2 pts, who completed 6 HD-MTX courses, experienced a complete remission of their lymphoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "2", "pts", ",", "who", "completed", ...
PMC9436459	Chalcomoracin (5), which is the first example of MDAAs, was isolated from the diseased mulberry leaves (M. alba) by Takasugi et al. in 1980 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787381	Outliers were identified by Grubb’s test (alpha = 0.2) and by abnormal behavior during test (e.g. freezing behavior during the test).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11502962	In this study, we aimed to determine the role of macrophages during tumor progression and cell-chat types between macrophages and tumor cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC5311252	Data from TCGA were accessed via the UCSC Cancer Browser.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "from", "TCGA", "were", "accessed", "via", "the", "UCSC", "Cancer", "Browser", "." ...
PMC10988555	E. coli transformed with pUC18 was inoculated onto a plate of LB-agar medium (Luria–Bertani) (Applichem, Darmstadt, Germany) supplemented with ampicillin (100 μg/mL) (Bioline, London, UK) and incubated for 24 h at 37 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Participants were followed-up for dose limiting toxicities (DLTs) for up to 12 weeks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Participants", "were", "followed-up", "for", "dose", "limiting", ...
PMC11706491	WT n = 224 cells, rep2Δ n = 51 cells, and cdc25-22 n = 34 cells. *:	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "WT", "n", ...
PMC11683240	α1AT, α1-antitrypsin; qRT-PCR, quantitative reverse transcription PCR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "α1AT", ",", "α1-antitrypsin", ";", "qRT-PCR", ",", "quantitative", "reverse", "transcription", "...
PMC11734514	While PTEN mRNA expression decreased in the graphical representation (Figure 2A), the band visualization (Figure 2E) suggested marginal differences.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Nineteen patients had at least one episode of neutropenic fever admissions of which ten patients had more than two episodes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nineteen", "patients", "had"...
PMC9429973	F. L. Locke, J. Chou, S. Vardhanabhuti, R. Perbost, P. Dreger, B. T. Hill, C. Lee, P. L. Zinzani, N. Kröger, A. López-Guillermo, H. Greinix, W. Zhang, G. Tiwari, C. To, P. Cheng, A. Bot, R. Shen, S. Filosto, J. Galon Moffitt Cancer Center, Tampa, FL; Kite, a Gilead Company, Santa Monica, CA, United States of America; H...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11391695	By means of recuperation experiments, the relationship between ACYP2 and TERT was elaborated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "By", "means", "of", "recuperation", "experiments", ",", "the", "...
PMC11186948	Class I HDACs (including HDAC1, 2, 3, 8) are ubiquitously expressed and they often participate in multi-molecular protein complexes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Class",...
PMC10798140	However, among the tested derivatives, compound 3c at 20 μm had the strongest potential to decrease or prevent HepG2 cell migration when compared with sorafenib.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", ...
PMC3734024	In particular, IL-10-producing B cells are enriched in both the CD5CD1d (sometimes referred to as “B10” cells) and CD23CD21IgM transitional 2-marginal zone precursor (T2-MZP) B cell subsets, although most IL-10-secreting B cells are distributed among other B cell subsets –. Previous studies in our laboratory had identi...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11640247	Given the distinct clinical features of this case compared to those seen in NEDBAF patients, we sought to investigate how the p.R66W variant impacts RAC3 function and contributes to this fetopathy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4355729	Altogether, through the activation of the PI3K/AKT pathway which phosphorylates several cytoskeleton-regulating and EMT–activating proteins, the downregulation of PIK3R1 promotes migration and EMT in renal cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Mutations in the spliceosome were enriched in cases with myeloid skewing, possibly representing cases with early oncogenic transformation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mutations", "in", "the", "spliceo...
PMC11402217	∗p < 0.05; ∗∗p < 0.01.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "∗p", "<", "0.05", ";", "∗∗p", "<", "0.01", "." ] } ]
PMC8414691	Fixed preparations of midbodies were stained with DAPI (blue), anti-α-Tubulin (green), and anti-SRCAP antibody (red).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fixed",...
PMC11672142	The Fe-dependent processes induced by DefNEtTrp result in the triggering of both apoptotic and ferroptotic cell death pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Fe-dependent", "processes", "induced"...
PMC11730320	Our patient was diagnosed after birth with profound T cell deficiency based on severe lymphopenia and reduced TRECs indicating an arrest or attenuation of T cell maturation in the thymus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11064533	Sequence-based analysis of target genes from transcriptomic data −, not detected.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sequence-based", "analysis", "of", "target", "genes", "from", "transcriptomic", "data"...
PMC11502443	p < 0.05 by unpaired t-test comparing the Emax of the same peptide at the WT and E354Q GIP receptor for each signaling pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11672617	Mitochondrial uncoupling is a crucial process not only for normal cells but also for the metabolic pathways involved in carcinogenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mitochondrial", "uncoupling", ...
PMC11627398	Additionally, MTF1 has been identified as playing a role in metal detoxification and maintaining metal redox homeostasis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "MTF1", "has", "be...
PMC11470999	For instance, thalidomide, originally used for morning sickness, is now used to treat multiple myeloma, and the immunosuppressant rapamycin is used for anticancer therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10968586	This piece of data is openly conflicting with reports documenting a loss of MDA-MB-231 viability after 72 h incubation at all tested HT doses (10–100 μM) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2614416	In hepatic neoplasia, all the key enzymes involved in the biosynthesis and utilization of IMP are found to increase [48-50], whereas the rate-limiting oxidoreductase enzyme of IMP catabolism, xanthine oxidase (EC:1.2.3.2), decreases sharply, in direct proportion to the severity of the disease .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The lack of awareness in early detection, as well as patients developing AL Amyloidosis after a MM diagnosis that are not classified with the second pathology, are the main reasons claimed by physicians that lead to a possible underdiagnosis in Portuguese hospitals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11092382	The effect of sophocarpine on LPS-induced inflammatory responses in RAW 264.7 cells was investigated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O" ], "tokens": [ "The", "effect", "of", "sophocarpine", "on", "LPS-induced",...
PMC10114490	PHH: cultured primary human hepatocytes from two different donors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PHH", ":", "cultured", "primary", "human", "hepatocytes", "from", "two", "different", "donors", ...
PMC7961460	All immunoprecipitates were washed five times with RIPA buffer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "immunoprecipitates", "were", "washed", "five", "times", "with", "RIPA", "buffer", "." ] } ]
PMC11680562	The pH of these mixtures was then determined using a pH meter.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "pH", "of", "these", "mixtures", "was", "then", "determined", "using", ...
PMC9429973	Results: The median achievement by the absolute number of neutrophils at the level 0.5x10/9/L and more in the groups was 10 (6-15), 13 (9-19), 10 (9-11) and 14 (10-18) days, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11367146	The elevated level of IL-1β stimulates the production of pro-inflammatory cytokines in articular cartilage indicating the correlation between inflammation and OA .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "elevated", ...
PMC9429973	These results represent the scientific rationale for the ongoing phase 3 GIMEMA LAL2820 trial, where dasatinib has been substituted by ponatinib, CNS prophylaxis has been increased, and transplant allocation is based on genomic features and minimal residual disease monitoring.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11463018	Such a pharmacophore model usually applies to all isoforms due to the highly conserved nature of HDAC family.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Such", "a", "pharmacophore", "model", ...
PMC11594074	Indeed, a significantly increased induction of late apoptosis ranging from 7.5% in untreated cells to 22.8% in cells treated with 2 × IC50 of compound 4 was confirmed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11106977	Similarly, a genetic deletion of OGT inhibited osteoclast formation and downregulated markers related to their differentiation and function, such as α(v) integrin and cathepsin K .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9436459	0.5 μg/mL (5-FU)BGC-823n.a.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "0.5", "μg/mL", "(5-FU)BGC-823n.a", "." ] } ]
PMC11502443	Fifty microliters of diluted peptide or media alone were added to the cells and incubated for 90 min at 37°C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fifty", "mic...
PMC9429973	This study will be performed in the context of in-patients setting for receiving the three HDMTX courses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "study", "will", "be", "performed", ...
PMC9429973	Aims: Our study therefore focuses on the biological characterization of the different progression stages of germline GATA2 deficiency patients and their correlation with clinic features.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10490530	Therefore, together these results imply that in a cellular condition with triggered NF-κB, suppressive p53 activation may prevail, which in turn may drive a less suppressive regulatory action of the PIK3CA gene promoter (Figure 5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7039683	A zGPAE 3 kb downstream of the cldne transcriptional start site possesses a GRHL motif but lacks other signature motifs (Figure 2B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11545868	Numerous flavonoids have been shown to lower the incidence of major cancers such as stomach, breast, prostate, and colorectal cancers, and many are candidates for drug selection .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8592717	Figure 3 illustrates the antioxidant mechanisms of the 2 metabolites through activation of multiple transcription factors in different cells, tissues, and organs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11545737	Immunostaining reveals that E-cadherin and claudin-1 were disturbed by sodium butyrate .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immunostaining", "reveals", "that", "E-cadherin", "and", "claudin-1", "were", "disturbed", ...
PMC9429973	Importantly, SUMOi amplified the activation of the STAT1 pathway in response to IFNg, which is one of the key regulators of cytokine-induced MHC-I expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10956161	All paraffin samples were cut into 4-mm thick sections and dewaxed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "paraffin", "samples", "were", "cut", "into", "4-mm", "thick", "sections", "and...
PMC11271278	HAPI cutoff is defined by the inflection point of each scoring metric.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HAPI", "cutoff", "is", "defined", "by", "the", "inflection", "point", "of", ...
PMC11438317	NS nonsignificant, P < 0.05,P < 0.01 and **P < 0.001 for comparison of proteins mutated in Tyr with the wild type protein Identification of the Tyr targeted by LYP in several potential substrates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11357960	2-D08 is a specific inhibitor of SUMOylation that blocks the transfer of SUMO protein from the SUMO-Conjugating Enzyme (Ubc9) thioester conjugate to substrates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	However, the bias between the automated and manual methods indicates that the two techniques should not be used interchangeably.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", ...
PMC9516401	Accordingly, this study evaluated the effects of five extracts, including the hydroalcoholic extracts of Phaseolus vulgaris (HEPV), Citrullus colocynthis (HECC), Portulaca oleracea (HEPO), Allium cepa (HEA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5311252	Out of the 525 potential targets defined here, 194 were found to inversely correlate with oncomotif-miRNA expression in the TCGA LUAD cohort (pearson correlation <−0.15, Supplementary Table 7).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754094	The oligonucleotide library was procured from GenScript and subsequently amplified employing the Phusion High-Fidelity DNA Polymerase (NEB).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "oligonucleotide", "library", ...
PMC9386809	Chemical shifts are reported in parts per million.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chemical", "shifts", "are", "reported", "in", "parts", "per", "million", "." ] } ]
PMC11612315	However, the results of the Hargreaves test indicated that the administration of 10 µg of exendin 9–39 decreased heat sensitivity upon intraplantar injection (Fig. 3a).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9143157	Human uterine sarcoma cell line MES-SA, the GPF-transfected cell line (MEA-SA C9), and its selected subset with a high metastatic potential (MEA-SA C9 high) were kindly provided by Prof. Yoshio Yoshida in the Department of Biochemistry, Medical Sciences, Fukui University, Japan.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC11621493	FFA release was determined using commercially available colorimetric kits. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FFA", "release", "was", "determined", "using", "commercially", "available", "colorimetric", "kits", ...
PMC11705630	With this information, we reasoned that increased mtROS induced by GLDC inhibition causes mitochondrial stress and damaged mtDNA to be released into the cytoplasm, resulting in the activation of ISGF3 signaling pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11055510	Circular RNAs (circRNAs) are stable, conserved, and functional biomolecules that can be used as effective biomarkers for various cancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Circula...
PMC8540692	The results of our study indicate that curcumin, with the Papp value of 5.337 × 10 ± 2.424 × 10 cm s can be considered highly permeable through the nasal cavity membranes (Figure 13).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11634027	Loss of the PCV, and disruption of wing hair polarity was observed, but these phenotypes were substantially weaker than in ds flies (Fig. 6L-O′).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11139449	MTT assays assessed gene silencing and cell viability at 24, 48, and 72 hours.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MTT", "assays", "assessed", "gene", "silencing", "and"...
PMC9370419	Estrogen treatment had been reported to suppress HBV DNA, RNA, and HBeAg expression in male athymic mice bearing 2.2.15 cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Estrogen", "...
PMC11711345	Suitable formulations that increase the GI residence time of these compounds, as in modulation of mucoadhesion, can be developed especially against gastrointestinal stromal tumors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10213199	DC.,	[ { "tags": [ "O", "O", "O" ], "tokens": [ "DC", ".", "," ] } ]
PMC11337594	Quantitative qRT‒PCR was conducted using the CFX384 Touch system (Bio-Rad, CA, USA) and the Genious 2x SYBR Green kit (RM21204#, ABclone, Wuhan, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5308810	Immunohistochemistry stainings were performed on the deparafiinized sections (6 μm), using antihuman CXCR4 monoclonal antibody (ab2074, Abcam, Cambridge, MA) and CD31 (1:100, ab125212, Abcam, Cambridge, MA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8623816	ORF1 from RsPV3 and RsPV4 encodes a putative RdRp, while ORF2 from RsPV3 and RsPV4 encodes a putative CP .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ORF1", "from", "RsPV3", ...
PMC11683240	Cells were left untreated as further control (Con) or incubated with AT and Fon only.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "left", "untreated", "as", ...
PMC11507371	Auranofin, for example, an inhibitor of the thioredoxin antioxidant system, reduces NF-κB expression and overcomes therapy resistance .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Auranofin", ",", "for", ...
PMC9910796	Transfected Cos cells expressing proteins pEP84R-Flag, pp62 and pp220 individually or in combination, were fixed and immunolabeled with rabbit antibodies to pEP84R (A, D and F) and pp220 (E); mouse mAbs to pp62 (B, D and F), pp220 (C) and Flag tag (E) or rat antibody to pp220 (F) as indicated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11388384	A prediction of our topology-limited diffusion model is that the degree of connectivity between cells can influence the formation of signaling gradients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "predict...
PMC11185260	Collectively, the addition of scL-SMARCB1 to cisplatin treatment promoted cisplatin-induced cytotoxicity in vivo and significantly improved the survival of ATRT-bearing mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Collectively", ...
PMC11488203	Enhanced tropism of taxol to primary cultures of human breast cancer-derived epithelial cells (HBCEC) as compared to primary cultures of normal human mammary epithelial cells (HMEC) has been described previously .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "...
PMC9964635	The most potent derivative was 7f, which contains two methyl groups at ortho-positions of the phenyl ring (IC50 value of 16.782 µM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11745823	In contrast, HIF‐1α overexpression did not affect the mutant (mut) RIT1 promoter activity (Figure 7B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",", ...
PMC9454178	Interestingly, we found that OSR1 was the predominantly downregulated gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "we", "found", "that", "OSR1", "was", "the", "predominantly", "d...
PMC11803149	Epas1 is dispensable for activation and cytolytic functions of CD8 T cells in vitro.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Epas1", "is", "dispensable", "for", "activation", "and", "cytolytic", ...
PMC6160470	One-way ANOVA with Tukey’s post-hoc test was used for statistical analysis (NS – non-significant; *p < 0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One-way", "A...
PMC11127909	However, the specific mechanism is still unclear.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "specific", "mechanism", "is", "still", "unclear", "." ] } ]
PMC11756907	It should be particularly emphasised that, irrespective of the dilution, no cytotoxic effect of GO, rGO, or their derivatives was demonstrated on human dermal fibroblasts (Figure 5), indicating the extremely interesting selectivity of the action of GO/ rGO complexes with 2-ME against tumour cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11743975	These indicate the successful aggregation of fragmentated mitochondria.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "indicate", "the", "successful", "aggregation", "of", "fragmentated", "mitochondria", "." ] } ]
PMC10938336	In Pakistan, acute leukemia is more common than chronic leukemia and affects males more frequently than females.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "Pakistan", ",", "acute", "leukem...
PMC11271278	Cross-linked chromatin was digested with the MboI restriction enzyme, filled with dNTPs including biotin labeled dATP, ligated with T4 DNA ligase, and sonicated to obtain chromatin fragments averaging ~1 kb in length using Qsonica (Q800).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11746948	The use of ML349, a specific APT2 inhibitor, corroborated these observations as treatment with ML349 raised GPX4 protein levels without altering its mRNA levels (Fig. 5g, h).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5941560	Our analysis identifies multiple dysfunctional pathways in the Jurkat cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Our", "analysis", "identifies", "multiple", "dysfunctional", "pathways", "in", "the", ...
PMC11714165	Furthermore, after only an hour of incubation with NBD‐F, the fluorescence was observed to be dispersed throughout the cells (Figure 2G), indicating that the cellular uptake and endosomal escape of NBD‐F are rapid and efficient due to the both hydrophobic and lipophobic properties of fluorous tags.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8973085	Anal.	[ { "tags": [ "O", "O" ], "tokens": [ "Anal", "." ] } ]
PMC10237474	We show that, like CHO-K1 stable pools, Expi293F stable pools generated by the PB transposon system consistently demonstrate high titers and protein yields.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ],...

PMC9119314

After the microplates were thawed, 100 μL from each well was transferred into a duplicate plate.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "the", "microplates", "were", "thawed", ...

PMC11745600

However, mice with STZ-induced diabetes exhibit considerable interindividual variation in blood glucose levels, and it is noteworthy that these mice occasionally demonstrate a restoration of their endogenous pancreatic β cells, which causes difficulty in interpretation when assessing the efficacy of cell transplantatio...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6742971

To determine the cytokine production by the CD8 T cell clones with different functional avidities, we performed IFN-γ Elispot assays, a well-suited method to compare T cell functions of different clones alone, as well as after mixing them in defined ratios (3).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11279397

The annual herb Perilla frutescens (L.) Britt.,

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "annual", "herb", "Perilla", "frutescens", "(", "L.", ")", "Britt", ".", "," ] ...

PMC10440586

Cox-analysis of eight different datasets.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cox-analysis", "of", "eight", "different", "datasets", "." ] } ]

PMC9429973

The 2 pts, who completed 6 HD-MTX courses, experienced a complete remission of their lymphoma.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "2", "pts", ",", "who", "completed", ...

PMC9436459

Chalcomoracin (5), which is the first example of MDAAs, was isolated from the diseased mulberry leaves (M. alba) by Takasugi et al. in 1980 .

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PMC11787381

Outliers were identified by Grubb’s test (alpha = 0.2) and by abnormal behavior during test (e.g. freezing behavior during the test).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11502962

In this study, we aimed to determine the role of macrophages during tumor progression and cell-chat types between macrophages and tumor cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...

PMC5311252

Data from TCGA were accessed via the UCSC Cancer Browser.

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PMC10988555

E. coli transformed with pUC18 was inoculated onto a plate of LB-agar medium (Luria–Bertani) (Applichem, Darmstadt, Germany) supplemented with ampicillin (100 μg/mL) (Bioline, London, UK) and incubated for 24 h at 37 °C.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Participants were followed-up for dose limiting toxicities (DLTs) for up to 12 weeks.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Participants", "were", "followed-up", "for", "dose", "limiting", ...

PMC11706491

WT n = 224 cells, rep2Δ n = 51 cells, and cdc25-22 n = 34 cells. *:

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "WT", "n", ...

PMC11683240

α1AT, α1-antitrypsin; qRT-PCR, quantitative reverse transcription PCR.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "α1AT", ",", "α1-antitrypsin", ";", "qRT-PCR", ",", "quantitative", "reverse", "transcription", "...

PMC11734514

While PTEN mRNA expression decreased in the graphical representation (Figure 2A), the band visualization (Figure 2E) suggested marginal differences.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC9429973

Nineteen patients had at least one episode of neutropenic fever admissions of which ten patients had more than two episodes.

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PMC9429973

F. L. Locke, J. Chou, S. Vardhanabhuti, R. Perbost, P. Dreger, B. T. Hill, C. Lee, P. L. Zinzani, N. Kröger, A. López-Guillermo, H. Greinix, W. Zhang, G. Tiwari, C. To, P. Cheng, A. Bot, R. Shen, S. Filosto, J. Galon Moffitt Cancer Center, Tampa, FL; Kite, a Gilead Company, Santa Monica, CA, United States of America; H...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11391695

By means of recuperation experiments, the relationship between ACYP2 and TERT was elaborated.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "By", "means", "of", "recuperation", "experiments", ",", "the", "...

PMC11186948

Class I HDACs (including HDAC1, 2, 3, 8) are ubiquitously expressed and they often participate in multi-molecular protein complexes.

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PMC10798140

However, among the tested derivatives, compound 3c at 20 μm had the strongest potential to decrease or prevent HepG2 cell migration when compared with sorafenib.

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PMC3734024

In particular, IL-10-producing B cells are enriched in both the CD5CD1d (sometimes referred to as “B10” cells) and CD23CD21IgM transitional 2-marginal zone precursor (T2-MZP) B cell subsets, although most IL-10-secreting B cells are distributed among other B cell subsets –. Previous studies in our laboratory had identi...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11640247

Given the distinct clinical features of this case compared to those seen in NEDBAF patients, we sought to investigate how the p.R66W variant impacts RAC3 function and contributes to this fetopathy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC4355729

Altogether, through the activation of the PI3K/AKT pathway which phosphorylates several cytoskeleton-regulating and EMT–activating proteins, the downregulation of PIK3R1 promotes migration and EMT in renal cancer cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Mutations in the spliceosome were enriched in cases with myeloid skewing, possibly representing cases with early oncogenic transformation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mutations", "in", "the", "spliceo...

PMC11402217

∗p < 0.05; ∗∗p < 0.01.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "∗p", "<", "0.05", ";", "∗∗p", "<", "0.01", "." ] } ]

PMC8414691

Fixed preparations of midbodies were stained with DAPI (blue), anti-α-Tubulin (green), and anti-SRCAP antibody (red).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fixed",...

PMC11672142

The Fe-dependent processes induced by DefNEtTrp result in the triggering of both apoptotic and ferroptotic cell death pathways.

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PMC11730320

Our patient was diagnosed after birth with profound T cell deficiency based on severe lymphopenia and reduced TRECs indicating an arrest or attenuation of T cell maturation in the thymus.

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PMC11064533

Sequence-based analysis of target genes from transcriptomic data −, not detected.

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PMC11502443

p < 0.05 by unpaired t-test comparing the Emax of the same peptide at the WT and E354Q GIP receptor for each signaling pathway.

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PMC11672617

Mitochondrial uncoupling is a crucial process not only for normal cells but also for the metabolic pathways involved in carcinogenesis.

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PMC11627398

Additionally, MTF1 has been identified as playing a role in metal detoxification and maintaining metal redox homeostasis .

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PMC11470999

For instance, thalidomide, originally used for morning sickness, is now used to treat multiple myeloma, and the immunosuppressant rapamycin is used for anticancer therapy.

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PMC10968586

This piece of data is openly conflicting with reports documenting a loss of MDA-MB-231 viability after 72 h incubation at all tested HT doses (10–100 μM) .

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PMC2614416

In hepatic neoplasia, all the key enzymes involved in the biosynthesis and utilization of IMP are found to increase [48-50], whereas the rate-limiting oxidoreductase enzyme of IMP catabolism, xanthine oxidase (EC:1.2.3.2), decreases sharply, in direct proportion to the severity of the disease .

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PMC9429973

The lack of awareness in early detection, as well as patients developing AL Amyloidosis after a MM diagnosis that are not classified with the second pathology, are the main reasons claimed by physicians that lead to a possible underdiagnosis in Portuguese hospitals.

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PMC11092382

The effect of sophocarpine on LPS-induced inflammatory responses in RAW 264.7 cells was investigated.

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PMC10114490

PHH: cultured primary human hepatocytes from two different donors.

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PMC7961460

All immunoprecipitates were washed five times with RIPA buffer.

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PMC11680562

The pH of these mixtures was then determined using a pH meter.

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PMC9429973

Results: The median achievement by the absolute number of neutrophils at the level 0.5x10/9/L and more in the groups was 10 (6-15), 13 (9-19), 10 (9-11) and 14 (10-18) days, respectively.

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PMC11367146

The elevated level of IL-1β stimulates the production of pro-inflammatory cytokines in articular cartilage indicating the correlation between inflammation and OA .

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PMC9429973

These results represent the scientific rationale for the ongoing phase 3 GIMEMA LAL2820 trial, where dasatinib has been substituted by ponatinib, CNS prophylaxis has been increased, and transplant allocation is based on genomic features and minimal residual disease monitoring.

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PMC11463018

Such a pharmacophore model usually applies to all isoforms due to the highly conserved nature of HDAC family.

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PMC11594074

Indeed, a significantly increased induction of late apoptosis ranging from 7.5% in untreated cells to 22.8% in cells treated with 2 × IC50 of compound 4 was confirmed.

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PMC11106977

Similarly, a genetic deletion of OGT inhibited osteoclast formation and downregulated markers related to their differentiation and function, such as α(v) integrin and cathepsin K .

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PMC9436459

0.5 μg/mL (5-FU)BGC-823n.a.

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PMC11502443

Fifty microliters of diluted peptide or media alone were added to the cells and incubated for 90 min at 37°C.

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PMC9429973

This study will be performed in the context of in-patients setting for receiving the three HDMTX courses.

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PMC9429973

Aims: Our study therefore focuses on the biological characterization of the different progression stages of germline GATA2 deficiency patients and their correlation with clinic features.

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PMC10490530

Therefore, together these results imply that in a cellular condition with triggered NF-κB, suppressive p53 activation may prevail, which in turn may drive a less suppressive regulatory action of the PIK3CA gene promoter (Figure 5).

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PMC7039683

A zGPAE 3 kb downstream of the cldne transcriptional start site possesses a GRHL motif but lacks other signature motifs (Figure 2B).

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PMC11545868

Numerous flavonoids have been shown to lower the incidence of major cancers such as stomach, breast, prostate, and colorectal cancers, and many are candidates for drug selection .

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PMC8592717

Figure 3 illustrates the antioxidant mechanisms of the 2 metabolites through activation of multiple transcription factors in different cells, tissues, and organs.

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PMC11545737

Immunostaining reveals that E-cadherin and claudin-1 were disturbed by sodium butyrate .

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PMC9429973

Importantly, SUMOi amplified the activation of the STAT1 pathway in response to IFNg, which is one of the key regulators of cytokine-induced MHC-I expression.

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PMC10956161

All paraffin samples were cut into 4-mm thick sections and dewaxed.

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PMC11271278

HAPI cutoff is defined by the inflection point of each scoring metric.

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PMC11438317

NS nonsignificant, *P < 0.05,**P < 0.01 and ***P < 0.001 for comparison of proteins mutated in Tyr with the wild type protein Identification of the Tyr targeted by LYP in several potential substrates.

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PMC11357960

2-D08 is a specific inhibitor of SUMOylation that blocks the transfer of SUMO protein from the SUMO-Conjugating Enzyme (Ubc9) thioester conjugate to substrates.

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PMC9429973

However, the bias between the automated and manual methods indicates that the two techniques should not be used interchangeably.

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PMC9516401

Accordingly, this study evaluated the effects of five extracts, including the hydroalcoholic extracts of Phaseolus vulgaris (HEPV), Citrullus colocynthis (HECC), Portulaca oleracea (HEPO), Allium cepa (HEA.

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PMC5311252

Out of the 525 potential targets defined here, 194 were found to inversely correlate with oncomotif-miRNA expression in the TCGA LUAD cohort (pearson correlation <−0.15, Supplementary Table 7).

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PMC11754094

The oligonucleotide library was procured from GenScript and subsequently amplified employing the Phusion High-Fidelity DNA Polymerase (NEB).

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PMC9386809

Chemical shifts are reported in parts per million.

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PMC11612315

However, the results of the Hargreaves test indicated that the administration of 10 µg of exendin 9–39 decreased heat sensitivity upon intraplantar injection (Fig. 3a).Fig.

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PMC9143157

Human uterine sarcoma cell line MES-SA, the GPF-transfected cell line (MEA-SA C9), and its selected subset with a high metastatic potential (MEA-SA C9 high) were kindly provided by Prof. Yoshio Yoshida in the Department of Biochemistry, Medical Sciences, Fukui University, Japan.

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PMC11621493

FFA release was determined using commercially available colorimetric kits. (

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PMC11705630

With this information, we reasoned that increased mtROS induced by GLDC inhibition causes mitochondrial stress and damaged mtDNA to be released into the cytoplasm, resulting in the activation of ISGF3 signaling pathway.

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PMC11055510

Circular RNAs (circRNAs) are stable, conserved, and functional biomolecules that can be used as effective biomarkers for various cancers.

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PMC8540692

The results of our study indicate that curcumin, with the Papp value of 5.337 × 10 ± 2.424 × 10 cm s can be considered highly permeable through the nasal cavity membranes (Figure 13).

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PMC11634027

Loss of the PCV, and disruption of wing hair polarity was observed, but these phenotypes were substantially weaker than in ds flies (Fig. 6L-O′).

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PMC11139449

MTT assays assessed gene silencing and cell viability at 24, 48, and 72 hours.

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PMC9370419

Estrogen treatment had been reported to suppress HBV DNA, RNA, and HBeAg expression in male athymic mice bearing 2.2.15 cells .

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PMC11711345

Suitable formulations that increase the GI residence time of these compounds, as in modulation of mucoadhesion, can be developed especially against gastrointestinal stromal tumors.

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PMC10213199

DC.,

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PMC11337594

Quantitative qRT‒PCR was conducted using the CFX384 Touch system (Bio-Rad, CA, USA) and the Genious 2x SYBR Green kit (RM21204#, ABclone, Wuhan, China).

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PMC5308810

Immunohistochemistry stainings were performed on the deparafiinized sections (6 μm), using antihuman CXCR4 monoclonal antibody (ab2074, Abcam, Cambridge, MA) and CD31 (1:100, ab125212, Abcam, Cambridge, MA).

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PMC8623816

ORF1 from RsPV3 and RsPV4 encodes a putative RdRp, while ORF2 from RsPV3 and RsPV4 encodes a putative CP .

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PMC11683240

Cells were left untreated as further control (Con) or incubated with AT and Fon only.

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PMC11507371

Auranofin, for example, an inhibitor of the thioredoxin antioxidant system, reduces NF-κB expression and overcomes therapy resistance .

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PMC9910796

Transfected Cos cells expressing proteins pEP84R-Flag, pp62 and pp220 individually or in combination, were fixed and immunolabeled with rabbit antibodies to pEP84R (A, D and F) and pp220 (E); mouse mAbs to pp62 (B, D and F), pp220 (C) and Flag tag (E) or rat antibody to pp220 (F) as indicated.

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PMC11388384

A prediction of our topology-limited diffusion model is that the degree of connectivity between cells can influence the formation of signaling gradients.

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PMC11185260

Collectively, the addition of scL-SMARCB1 to cisplatin treatment promoted cisplatin-induced cytotoxicity in vivo and significantly improved the survival of ATRT-bearing mice.

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PMC11488203

Enhanced tropism of taxol to primary cultures of human breast cancer-derived epithelial cells (HBCEC) as compared to primary cultures of normal human mammary epithelial cells (HMEC) has been described previously .

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PMC9964635

The most potent derivative was 7f, which contains two methyl groups at ortho-positions of the phenyl ring (IC50 value of 16.782 µM).

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PMC11745823

In contrast, HIF‐1α overexpression did not affect the mutant (mut) RIT1 promoter activity (Figure 7B).

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PMC9454178

Interestingly, we found that OSR1 was the predominantly downregulated gene.

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PMC11803149

Epas1 is dispensable for activation and cytolytic functions of CD8 T cells in vitro.

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PMC6160470

One-way ANOVA with Tukey’s post-hoc test was used for statistical analysis (NS – non-significant; *p < 0.05).

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PMC11127909

However, the specific mechanism is still unclear.

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PMC11756907

It should be particularly emphasised that, irrespective of the dilution, no cytotoxic effect of GO, rGO, or their derivatives was demonstrated on human dermal fibroblasts (Figure 5), indicating the extremely interesting selectivity of the action of GO/ rGO complexes with 2-ME against tumour cells.

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PMC11743975

These indicate the successful aggregation of fragmentated mitochondria.

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PMC10938336

In Pakistan, acute leukemia is more common than chronic leukemia and affects males more frequently than females.

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PMC11271278

Cross-linked chromatin was digested with the MboI restriction enzyme, filled with dNTPs including biotin labeled dATP, ligated with T4 DNA ligase, and sonicated to obtain chromatin fragments averaging ~1 kb in length using Qsonica (Q800).

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PMC11746948

The use of ML349, a specific APT2 inhibitor, corroborated these observations as treatment with ML349 raised GPX4 protein levels without altering its mRNA levels (Fig. 5g, h).

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PMC5941560

Our analysis identifies multiple dysfunctional pathways in the Jurkat cell line.

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PMC11714165

Furthermore, after only an hour of incubation with NBD‐F, the fluorescence was observed to be dispersed throughout the cells (Figure 2G), indicating that the cellular uptake and endosomal escape of NBD‐F are rapid and efficient due to the both hydrophobic and lipophobic properties of fluorous tags.

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PMC8973085

Anal.

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PMC10237474

We show that, like CHO-K1 stable pools, Expi293F stable pools generated by the PB transposon system consistently demonstrate high titers and protein yields.

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