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OTAR3088
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BioData-CellLine_annotated

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PMC10968586
However, one report documented the absence of effects on cell viability after treating HepG2 cells with 10–10 M OLE for 24 h , and another study described no effect on HepG2 cell viability after 48 h incubation with 15–200 μM OLE .
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PMC4355729
The protein levels of PIK3R1 were also significantly decreased in 786 and A-704 mutated cells respectively (P < 0.01; P < 0.01) (Fig. 2b).
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PMC11680391
The expected results can be utilized to target the future training and communication between the dairy farmer and the herd veterinarian, with the benefit of improved mutual communication between the stakeholders involved.
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PMC11753435
It is noteworthy that UltraID uses both adenosine 5′-triphosphate and biotin as substrates for its biotinylating function (35).
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PMC11770130
d, e Ceramide C16-C24 levels (d) or individual ceramide levels (e) in eWATs of control and Ntsr2 AKO mice (n = 6).
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PMC9429973
Systemic exposure increased across lisaftoclax doses from 20 to 800 mg, with an average half-life of 4 to 6 hours.
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PMC9429973
The molecular analysis of TNFRSF13B genes was performed by was PCR sequencing.
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PMC6163708
Transcription factors GLI1–3 are the downstream effectors of HH and activate oncogenic targets.
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PMC7039683
Briefly, GMSM-K cells were electroporated with plasmid using the Amaxa Cell Line Nucleofector Kit (Lonza, Cologne, Germany) and the Nucleofector II instrument (Lonza).
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PMC10887351
Ewing sarcoma (ES) is one of the most common pediatric malignant tumors, reported to represent about 2% of all childhood cancers .
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PMC11564322
The data are expressed as means ± SD of three independent experiments, each of which consisted of six replicates per treatment group. *
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PMC11476004
Blood from dogs was obtained during veterinary examinations.
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PMC11637276
For p38 activation/inhibition, cells were serum starved for 24 h, pretreated with SB202190, SB253080, or DMSO for 1 h before being treated with 250 mM sorbitol for 15 min.
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PMC11562028
A tumor-bearing mouse model using A498 cells as the cancer cells was established to evaluate the inhibitory effect of the Re-CDs on renal cell carcinoma in vivo (Fig. 7).
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PMC11534035
On t-test analysis, the SERPINE1/PAI1 knockdown in CAL39 cells did not lead to a statistically significant change in the number of colonies formed (Figure 6E).
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PMC11366496
Moreover, the Cignal finder cancer 10‐pathway reporter array revealed that the JAK/STAT signaling axis showed a significant inhibition due to RNF122 knocking down in LN‐229 and A‐172 cells, in contrast to the other signaling axis.
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PMC11746942
The sections were stained with Weigert’s iron hematoxylin for nuclei, followed by Biebrich scarlet-acid fuchsin for muscle fibers and cytoplasm.
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PMC10674574
The Papp value determines the rate of transport of the substance across the Caco-2 monolayer.
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PMC9429973
Similar results were observed for Isa-RVd vs. RVd among the common major single high-risk cytogenetic features: del17p: 56.0% (14/25) vs. 35.3% (12/34), OR=2.33, 95% CI: 0.82-6.88; t(4;14): 57.6% (19/33) vs. 47.1% (16/34), OR=1.53, 95% CI: 0.58-4.06; t(14;16): 66.7% (6/9) vs. 50.0% (4/8), OR=2.00, 95% CI: 0.28-15.67; g...
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PMC11206502
Halogenated boroxine K2[B3O3F4OH] (HB), an inorganic derivative of cyclic anhydride of boronic acid, is patented as a boron-containing compound with potential for the treatment of both benign and malignant skin changes.
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PMC9635307
We observed significantly more CEACAM1 expression on B cells compared to T cells in secondary lymphoid tissues (Fig. 1a).
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PMC6461034
Oncogene‐driven cancer cell lines analyzed by phosphoproteomics for this study.
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PMC9429973
When comparing the occurrence of second malignancies, an increased incidence was seen in CML patients (64·4% vs 17·2%, OR 8·72 (7·955, 9·549)).
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PMC10006224
The number of loops in each category is indicated below.
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PMC9688728
Cells were grown for 5, 10, 15, and 20 days from the start of the experiment as designated.
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PMC9429973
Summary/Conclusion: These two educational activities resulted in significant educational impact, particularly for hem/oncs.
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PMC11696576
i (i) intracellular ROS or (ii) cell death measured by ROS-red or PI staining in cells expressing cPLA2-sh or NTC-sh using flow cytometry.
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PMC10998613
We also report here that epinephrine increases the CXCR4- β2AR heteromerization.
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PMC9429973
EMA tests were also negative in 4 patients (half of them also OFT negative, with one patient having a uncertainly significance in SLC4A gene and one patient in SPTB gene, a novel variant that was probably pathological).
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PMC9429973
These animals also show iron deposition in the liver and kidney, in agreement with very low levels of hepcidin expression in the liver, and elevated erythropoietin (EPO) in the kidney.
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PMC10933092
A total of 38,939 mRNAs and 23,592 lncRNAs were annotated from the RNA-seq data using GENCODE (v23) annotations.
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PMC9917080
Following 48 h of incubation of A-172 cells with SeNPs, suppression of the expression of most kinase-encoding genes, comparable with SeSo, was observed, with the exception of MAPK3 and FLT3, the level of which increased, and RAF and KIT, the expression of which did not change (Figure 10B, red columns).
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PMC11098378
Data in C-F are means ± SD; n = 3.
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PMC11366496
Normal human astrocytes (HA) were cultivated in an astrocyte medium (Zeye Biotechnology, Shanghai, China).
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PMC11640419
Subsequently, 50 μL of the was added to each well, and the samples were incubated for one hour at 4 °C on an orbital shaker set at 700–850 rpm.
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PMC11075223
After amplification of the ITS2 nuclear gene sequence, a Neighbor-Joining tree was constructed and each species of Cimicifugae Rhizoma was divided into one branch, with significant inter species differences that can be distinguished from adulterants .
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PMC11319300
It might actively contribute to oncogenic processes through DNA amplifications or chromosomal translocations of this locus containing both CCND1 and MYEOV-3′-putative enhancer (Janssen et al., 2002b; Zhou et al., 2022), potentially allowing it to influence the expression levels of other proto-oncogenes (in addition to ...
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PMC11001582
However, at 12 months of age, polyGR and polyPR mice showed a nearly 20% reduction in the number of motor neurons in the lumbar spinal cord (Fig. 4e), while eGFP knock-in mice showed no reduction (Extended Data Fig. 6d).
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PMC9429973
In the group of patients treated with Imono, the majority of patients achieved partial remission or partial remission with lymphocytosis by 12 months.
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PMC11781181
Importantly, patients with SJS/TEN administered 300 mg/kg NAC experienced a reversal in the evolving SJS/TEN process 30.
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PMC9599726
IC50s were calculated using Prism 7 software (GraphPad Software, Inc., La Jolla, CA, USA) and CompuSyn software (https://www.combosyn.com/, accessed on 18 August 2022) Cohorts of archival GIST primary tumors and metastatic GISTs from formalin-fixed slides, paraffin-embedded (FFPE) material, and tissue microarrays (TMA)...
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PMC10495912
TQ, Thymoquinone; H2O2, hydrogen peroxide Effect of Thymoquinone on Oxidant/Antioxidant Status in Hydrogen Peroxide–Exposed HepG2 Cells.
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PMC10748106
Although these cancer cell lines are from the cervix, they exhibit different molecular characteristics.
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PMC11538390
We independently transfected these constructs into primary human neonatal epidermal keratinocytes (HEKn).
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PMC11805741
ND: Not Detected.
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PMC5673955
To investigate dose‐dependent activity Jurkat and CD4 T cells were incubated for 9 h with different concentrations of RrA. (C) Time‐dependent and (D) dose‐dependent expression of hTERT measured real‐time RT‐PCR in Jurkat and CD4 cells.
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PMC9812014
These extracted alkaloids were evaluated in Vero cells for antiviral activity against CV B3.
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PMC11711127
During the immune synapse, there is a bidirectional release of extracellular vesicles, known as SV, which transfer information that can modulate and mediate the function of the T cell.
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PMC11803149
n = 10 (aged tumor-bearing mice), n = 8 (young tumor-bearing mice), and n = 3 (PBS). (
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PMC11045125
Raw counts were normalized using the TMM normalization method using edgeR and the normalized gene counts were transformed to log2 scale using the voom method from the R Limma package , then used for differential expression analysis.
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PMC11252033
Transcriptomic analysis of Bcl-2, Bcl-xl and CryZ genes in A2780S and A2780R; data represent mean ± SD of at three independent experiments (*p < 0.05 vs. A2780S). (
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PMC11544122
Coelenterazine-H (1 µM) was added, and BRET was immediately measured in a microplate reader at room temperature.
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PMC8358006
c Experimental design to test the role of GSDs mediated oncogenesis candidates in cell proliferation and subcutaneous tumor growth.
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PMC11469524
Consequently, activation can occur independent of ligands or stimuli.
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PMC11803918
Since hybrid exosomes showed photosensitive ROS production and induced cancer cell apoptosis, we proposed that they could also induce the ICD effect in A375 cancer cells upon light irradiation.
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PMC11680982
Tumor inhibition rates and (D) tumor growth curves of HR/HER2-low tumor-bearing mice in various groups.
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PMC6160470
Additionally, the effect of crown ethers on plasma membrane disruption becomes prominent only at higher compound concentrations.
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PMC11347429
Comparison of infected patients versus healthy controls. (
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PMC11361748
Comparative analysis of transcriptomic data sets suggests that TAR, as observed in mouse skin under acute stress, is relevant to human inflammatory skin diseases.
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PMC11040965
Data from GSE4581 (left) and GSE9782 (right).
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PMC11591794
Therefore, the induction of P53 is important for the suppression of tumor proliferation.
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PMC9874064
These results suggest that inhibition of the expression of USP1 has great potential to inhibit DNA repair, leading to increased DNA damage originated from DNA alkylating agents such as cisplatin, and ultimately enhancing the anti-tumor effect.
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PMC11721277
The highest radioactivity accumulation of Tc-labeled HYNIC-Chl was observed in the liver and was greater than 25%ID/g at all doses studied (p > 0.05).
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PMC7090062
MicroRNA-30a (miR-30a), as a member of the miR-30 family, has similar functions to many other miRNA species and plays a role in cancer cell proliferation, invasion, metastasis, and autophagy.
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PMC5941560
We detect numerous examples of each examined variant type and use various strategies to tie these variants to functional effects.
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PMC11738017
Medscape, LLC is jointly accredited with commendation by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
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PMC11429241
The microstructures fabricated showed great biocompatability with both cell lines that were used.
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PMC11802855
A deeper understanding of CXCL7’s mechanisms, coupled with the development of effective inhibitors, will be essential for advancing therapeutic options and improving patient care.
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PMC11409031
We believe that this may be one of the reasons why low-risk patients have survival advantages.
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PMC9429973
Unfortunately, the study was prematurely closed due to low accrual.
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PMC11222184
PPP1R15A is another gene involved in DNA damage and repair mechanisms and has been reported to be overexpressed in association with chemoresistance in acute myeloid leukemia .
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PMC3765139
Since CD133+ melanoma cells are rare in clinical samples and difficult to isolate from surgical specimens, the expression of stem cell surface markers, in particular CD133, was analyzed in 9 well-established human melanoma cell lines, each and every one originally derived from human metastatic malignant melanoma.
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PMC11357960
For variables that were not normally distributed, a Mann-Whitney U test or Kruskal-Wallis ANOVA test was used.
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PMC11768927
VSV enhances anti-tumor immunity by inducing immunogenic tumor cell death, which releases tumor-associated antigens and promotes immune activation.
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PMC10605143
Therefore, elevated HSF1 levels are likely relevant to the hyperplastic changes in the breast.
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PMC11714165
Female BALB/c nude mice, aged 5 weeks, were purchased from GemPharmatech (Nanjing, China).
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PMC11342785
C, epifluorescence images of TPPP droplet formation.
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PMC9429973
Overall, 84.7% of pts (including all ALL pts) with HiDD had normal Fib; APL pts were more likely to have both HiDD and LowFib than AML pts (42.9% and 7.0%, respectively, p<0.001).
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PMC11760643
The MFI of anti‐P2X7 mAb labelling was determined using the geometric mean function of FlowJo software v10.7.1.
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PMC11634027
D-F) Wing discs of hs-Flp; ds/ds; Act>stop>EGFP:Dachs/+ (D), hs-Flp; ds/ds; Act>stop>EGFP:Dachs/+ (E), or hs-Flp; ds/ds; Act>stop>EGFP:Dachs/+ (F) stained for Wg (white) and E-cadherin (Shotgun) (red) with clones expressing Dachs:GFP (green/white).
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PMC11543885
Database Search: Search the raw MS files against the UniProtKB human sequence database (UP000005640).c.
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PMC11467964
In a previous study, Jayadev R. et al. proved that BMRG provide promising insight into the prognosis prediction of tumors.
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PMC11036064
Consistent with this, hsa-miR-34a-5p considerably downregulates MMP2 mRNA expression, and the combined therapy has lower MMP2 expression compared to temozolomide group (P-value < 0.0001, and P-value = 0.0006, respectively) (Figure 8B(Fig.
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PMC9429973
Our results suggested that STAG2 mutation did not act as driver and could be related to clonal hematopoiesis.
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PMC11515150
CD5 CCRF-CEM cells and CD5 CAR-NK cells or NT-NK cells were cocultured overnight at the indicated E: T ratio (n = 3; two-way ANOVA; **p < 0.01) (left panel).
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PMC9429973
Upon HES6 knockdown in CD34+ cells, a significant reduction in the number of megakaryocytes (50-85%) and erythroblasts (75-85%) was observed.
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PMC11530949
The HepG2 liver cancer cells displayed a critical decrease in viability at concentrations of 50 µg/ml (P<0.05) of the extract, as well as after treatment with the bio-synthesized NPs at concentrations extending from 6.25 to 50 µg/mL (P<0.001).
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PMC11683130
Endogenous and exogenous proteases, such as caspases, cathepsins, kallikreins and proteases from microorganisms, play important roles in the desquamation and defense regulation of the stratum corneum.
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PMC6892818
Equal loading for human epithelial cell lysate was confirmed by CK18 detection (see Methods).
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PMC11548041
EpCAM is a type 1 transmembrane glycoprotein that is expressed on embryonic stem cells, hepatic progenitor cells, and healthy epithelial tissues and furthermore is aberrantly overexpressed in many epithelial-derived cancers .
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PMC11361748
After setting the minimum threshold to 3,000 to minimize background noise, the number of PLA dots per EGFP-positive cell was calculated using ImageJ’s Analyze Particles function to automatically count particles larger than 0.3 μm.
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PMC4443654
and area under the receiver operating characteristic curve (AUROC). (
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PMC6461034
Kinases in bold type are intended drug targets while kinases that are off‐targets are given in plain type.
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PMC6364197
The treatment of Jurkat cells cultured on CTCPS with Ara-C, DNR or their combination revealed low sensitivity compared with TCPS until the 168 h. The conclusion of the experiment proves that DDR1/STAT3 mediated mechanism may be the reason of Jurkat cell chemoresistance.
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PMC7154001
However, both M3 and fisetin exhibited similar cytotoxic activities against the endothelial EAhy 926 cell line (IC50 72 vs. 76 µM).
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PMC9118379
To identify SAVs at the proteomic level, a proteogenomics approach is usually applied, which utilizes the single nucleotide variant (SNV) information derived from next-generation sequencing of genomic or transcriptomic data to generate SAV-harboring protein sequences and identify SAV variant peptides from mass spectrom...
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PMC3675084
BPR0L075 treatment (10–100 nM for 24 hours) caused immediate induction of MPM-2 in parental cells, but not in the resistant sublines that have mitotic defects (Figure 5A, B).
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PMC11674441
Sequence data analysis was performed with Bowtie2 aligner v2.5.0 .
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PMC10898159
Normal KIT chromosomal has CTCF insulator creating a topological boundary.
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PMC11200978
For instance, following a repeat 5 min freeze (5/5/5) with 17Ga PSN cryoneedle, the ablative volume would increase from ~55% to ~75% of the frozen tissue volume (e.g., 8.58 cm (±0.32) to 12.1 cm (±0.43)) .
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