OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11317131	Both PE and insertion efficiency are measured using ddPCR using reverse primers found on the att site or donor plasmid, respectively. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", ...
PMC9739791	Prodrugs 17–26 were conjugated through a linker in the side aliphatic moiety of a pyrrole scaffold.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Prodrugs", "17–26", "were", "conjugated", "through", "...
PMC9429973	Aims: We aimed to investigate efficacy and safety of first line R-CPOP in DLBCL patients with significant cardiac morbidity or high risk of anthracycline induced cardiotoxicity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5308810	Particularly in OVC, silencing CXCR4 expression by siRNA reduces tumor growth .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Particularly", "in", "OVC", ",", "silencing", "CXCR4", "expression", "by", "siRN...
PMC11594588	The full blood count is often enriched with a description of red blood cell parameters (MCV, MCH, MCHC) and platelet parameters (MPV, PDW, and pct), granulocytes, lymphocytes, eosinophils, and basophils.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11680562	Subsequently, the plates were incubated overnight in an incubator at 37 °C with 5% CO2 to promote adhesion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", ...
PMC8358176	Expression of CD40 reduced in MWCNT-treated (-1.01 ± 0.08) and PBS-treated (-2.03 ± 0.28) cells but increased in SWCNT-treated cells (1.75 ± 0.11; p = 0.083).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10092581	The main molecular mechanisms involved in oxaliplatin resistance appears to depend upon: (i) decreased cellular accumulation, which is thought to be related to a greater activity of the ATP7B exporter rather than to the activity of P‐glycoprotein (P‐gp) and multidrug resistance protein 1 (MRP1), and (ii) more efficient...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Moreover, LC-MBL showed overexpression of genes implicated in antigen processing and presentation and OXPHOS compared to either HC-MBL or CLL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "...
PMC11407042	A549 cell line culture medium Alternatives: 1% antibiotics (50 U/mL of penicillin-streptomycin) can be added to prevent contamination.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A549", ...
PMC9429973	Thyroid gland involvement is rare, and solitary thyroid gland involvement with LCH is extremely rare, with most cases presenting as part of multisystem disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	For NSC23766 only, the presence of NPM1 mutation was associated with more severe apoptosis and necrosis (p=0.01).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "NSC23766", "only", ...
PMC11367146	Notably, there is a consistent region between residues 28–80 where the plot remains constant, indicating a missing or disordered structure contributing to instability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9621239	β-actin was used as a loading control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "β-actin", "was", "used", "as", "a", "loading", "control", "." ] } ]
PMC10891340	In the uninfected group, it can be observed that the degradation of MFN2 was induced by the CCCP treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "uninfected", ...
PMC11695623	The diagnostic and prognostic value of DCUN1D5 in patients with LUAD was analyzed by TCGA, GEPIA and Kaplan–Meier Plotter database.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC9429973	The Sequenom MassArray system (Sequenom, San Diego, CA) was used to detect three SNPs genotypes in the HIF1A gene: rs11549465, rs1957757 and rs2057482.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11635087	We conducted an imaging PAM analysis to measure the effective quantum yield (φII) of the chloroplasts in CHO-K1 cells at 0, 2, and 4 days after the co-cultivation (Fig. 6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", ...
PMC11730320	The variant was validated by PCR and Sanger sequencing and correctly segregated in the nuclear family.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "variant", "was", "validated", "by", "PCR", ...
PMC9429973	Broad-spectrum azoles and echinocandin can be used as prophylaxis in patients receiving new targeted therapies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Broad-spectrum", "azoles", "and", "echinocandin", "can", "be", ...
PMC11788920	The achieved suppression and activation in Burkitt’s Lymphoma cell line and in in vitro studies are at or beyond those reported with alternative approaches.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	The in vitro assays with MM cell lines showed that the SCFAs acetate, butyrate and propionate had an antiproliferative effect (Fig. 1E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10380508	Metastasis and recurrence are common in RCC patients, leading to poor clinical outcomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Metastasis", "and", "recurrence", "are", "common", "in", "RCC", ...
PMC11700165	Upon stimulation these kinases translocate from the cytoplasm to the nucleus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Upon", "stimulation", "these", "kinases", "translocate", "from", "the", "cytoplasm", "to", ...
PMC11591038	The main components of the tumor microenvironment include blood vessels, lymphatic vessels, extracellular matrix, various immune cells, and fibroblasts .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11637716	Furthermore, these variants were not listed in the ClinVar and LOVD databases at the time of the study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "these", "vari...
PMC11711871	Overall, both GR rat models developed salt-sensitive hypertension, although they had different predispositions to standard diet, namely, hypercorticosteronemia in GR and normal plasma corticosteroid levels in GR rats.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	L. Minarik, T. Stopka, Z. Zemanova, A. Jonasova Clinic of Hematology, General University Hospital and First Faculty of Medicine, Charles University, Prague; 1st Faculty of Medicine, BIOCEV, Vestec; Center of Oncocytogenomics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11670954	Our findings corroborate those of previous studies investigating the beneficial effects of BA on cellular viability and the modulation of tight junction protein expression in epithelial cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: We showed that full APEX1 KO HSPCs failed to repopulate irradiated recipient mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "We", "showed", "that", "full", "APEX1", ...
PMC7823217	Cervical cancer is divided into two main subtypes namely squamous cell carcinoma and adenocarcinoma that account for 70% and 25% cervical cancer cases, respectively .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10203589	For most countries, the diagnosis is usually too late for radical treatment due to the lack of a good system in terms of diagnostic and screening methods (40–42).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11634794	Consequently, we propose the existence of a regulatory pathway involving VHL-LC3C-LAMP1 in ccRCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consequently", ",", "we", "propose", "the", "existence", "of", "...
PMC8389560	The study of these mechanisms is important for understanding the cytotoxic effect of selenium nanoparticles and the role of this microelement in the regulation of carcinogenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11637276	Cells were then incubated with the respective primary antibodies for 1 h at room temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "then", "incubated", "with", "the", "respec...
PMC9504875	We investigated whether and how nairoviruses antagonize host innate immunity using Hazara orthonairovirus (HAZV) as a surrogate model for Crimean-Congo hemorrhagic fever virus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11216402	Because we do not have an independent metric to assess the quality of the RNA-seq, we weighted the ATAC-seq more heavily for SNU484 and labelled it Epi-like.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11791264	∗p < 0.05, ∗∗p < 0.01 (Two-way ANOVA followed by Tukey’s multiple comparison).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "∗p", "<", "0.05", ",", "∗∗p", "<", "0...
PMC9429973	Methods: Pts with ≥6 mo of data, or pts who discontinued the study prior to Month 6 were included.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "P...
PMC10033453	Interpolated time point at which 50% of maximal cell death occurs at each MOI of VMG from the data in (A). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11770746	Interestingly, the platinum levels in the tumor for cisplatin, coadministration of cisplatin and paclitaxel, and cisPt(Pac)(OH) were rather similar, reinforcing the indication that for effective inhibition of the tumor growth, both cisplatin and paclitaxel need to accumulate in the tumor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11637276	To confirm the relevance of this process to different cancer types, A2780-Rab25 cells were treated with 50 μM SB203580 or siRNAs against MAP3K1, MAPK11, PPP2R1A, and α2 integrin and seeded on CDM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11792766	The EFSA guidelines involve the Ames test and the in vitro micronucleus assay as tools for the mandatory assessment of the genotoxic potential of food contact chemicals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4355729	Briefly, 4 × 10 cells were seeded into a 24 well plate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Briefly", ",", "4", "×", "10", "cells", "were", "seeded", "into", ...
PMC11592008	The main aim of this study was to identify the most suitable in vitro model for analyzing inflammasome signaling in keratinocytes by comparing PKs with three immortalized keratinocyte cell lines—HaCaT, HaSKpw, and SVTERT—in terms of inflammasome activation and detection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11679326	Thus, a high level of paucimannosylation in U-87 MG and U-138 MG glioblastoma cell lines with a predominant glycan structure Man3GlcNAc2Fuc, which consists of a naked trimannosyl core and a fucosylated N-acetylglucosamine residue in the chitobiose core and is processed by the enzymes α-mannosidases 2 from the MAN2 fami...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787651	A, number of peptides identified by EpiProfile 2.2 in three biological replicates analyzed with the 55-min nanoflow gradient on the Orbitrap Exploris or the 5- or 10-min microflow gradient on the ZenoTOF.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11653168	To assess the cytotoxic effects of Stattic on T-ALL cells, CCRF-CEM (Fig. 1A) and Jurkat cells (Fig. 1B) were treated with increasing concentrations of Stattic (0.625, 1.25, 2.5, 5 and 10 µM) or vehicle control (DMSO) for 24 h. Cell viability was measured using the CCK-8 assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "...
PMC9429973	More studies should be done on the current matter with adjustments for confounding variables.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "More", "studies", "should", "be", "done", "on", "the", "current"...
PMC8494202	Then, cDNA was reverse transcribed from total RNA using NovoScript Plus All-in-one 1st Strand cDNA Synthesis SuperMix (Novoprotein, Shanghai, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11703992	B The MR analysis process of ARHGAP15.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "The", "MR", "analysis", "process", "of", "ARHGAP15", "." ] } ]
PMC11673128	In this setting, immunotherapy could be a feasible approach since ALK peptides are known to be immunogenic and able to elicit a robust adaptive immune response in patients .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9739791	To confirm that upon light-induced activation with riboflavin Pt(IV) prodrugs release species that could bind with DNA, the formation of DNA cross-links was studied by circle dichroism (CD) and MALDI-TOF spectra.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The control group received conventional symptomatic treatment, while the test group was treated with LLLT in addition to the symptomatic treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "contr...
PMC9436459	As outlined in Scheme 2, the authors started the preparation of the chalcone dienophile S3 from ketone S1 and aldehyde S2 via Claisen-Schmidt condensation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11412752	Additionally, while STING expression is not detected in mouse and human primary hepatocytes, it is expressed and functional in HepG2 cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ ...
PMC11307990	The agarose gel electrophoresis image illustrated the stability of 6HB-DONs and DNA nanotapes in the 1640 medium with 10% FBS for 24–72 h at 37 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10674574	Furthermore, to establish transport conditions through the Caco-2 monolayer, preliminary experiments can be performed only in one direction (B–A) in a transport buffer at a pH of 7.4 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8170755	The cells were detached from the old culture using 0.25 mg/mL trypsin/EDTA (Invitrogen).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", "detached", "from", "the", "old", ...
PMC6450504	At pH 5.0, release from PEIPOS was faster than that at neutral pH. Together, the behavior of PEIPOS in both pH conditions, lead to the conclusion that the PEIPOS can retain the majority of the hydrophobic drug in an environment that resembles the circulation and upon reaching the tumor microenvironment, and particularl...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9910796	Similar to most retroviral Gag precursors, pp220 uses N-myristoylation to facilitate membrane binding.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similar", "to", "most", "retroviral", "Gag", "precursors", ",", ...
PMC9429973	So, 108 genes directly related to the downstream signaling of eltrombopag, cytokine signaling pathways, cytotoxic pathways, growth factors, adhesion molecules, apoptotic mechanisms and physiological mechanisms of platelet production are analyzed in peripheral blood from 35 refractory and 35 controls who responded to th...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11655498	Recent studies have successfully isolated human extrachromosomal DNAs using CRISPR-CATCH (Hung et al., 2022).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recent", "studies", "have", "successfully", "isol...
PMC11770130	Many chemicals have more than one target in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Many", "chemicals", "have", "more", "than", "one", "target", "in", "vivo", "." ] } ]
PMC11748335	This suggests that long LOCKs relate to the inhibition of the expression of genes and OGs within their vicinity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "suggests", "that", "long"...
PMC11733919	Physico-chemical characterization of the nanoplatform. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Physico-chemical", "characterization", "of", "the", "nanoplatform", ".", "(" ] } ]
PMC9429973	CR rates were consistent in patients with and without prior CAR-Ts (32% vs 37%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CR", "rates", "were", "consistent", "i...
PMC8427838	p < 0.001 Knockout of moesin in 786-0 cells inhibits TMIGD1-dependent α-tubulin acetylation and F-actin orientation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.001", ...
PMC7039683	Under a dissecting microscope, the epithelium was isolated for ATAC-seq by gently peeling using microforceps.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Under", "a", "dissecting", "microscope", ",", "the", ...
PMC10158546	We also observed increased abundance of PRNP mRNA throughout differentiation in both ReN WT and empty cells, but not 129 M cells (Figure 3d).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11701801	This indicates that KREMEN2 expression could be increased by cBAF deficiency induced by SS18–SSX fusion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "indicates", "that", "KREMEN2", "expression", "could", ...
PMC11248911	The sulfur atom representing the zinc binding group interacted with the Zn ion, Tyr381 and His301 amino acids of the enzyme, while the NH group formed H-bond interaction with Ala262, also the phenyl ring interacted with Met263 amino acid.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Image: Summary/Conclusion: After >2 years of follow-up, asciminib continued to show clinically and statistically significant, superior efficacy and better safety/tolerability vs BOS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11707832	The link between MAN2B1 and mannosidosis has been reviewed elsewhere .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "link", "between", "MAN2B1", "and", "mannosidosis", "has", "been", "reviewed", "elsewhere"...
PMC8009078	Hence, the MM-GBSA was used to calculate the binding free energy (∆Gbind) of the TMPRSS2 inhibitors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hence", ",", "the", "MM-GBSA", ...
PMC9429973	Final libraries were run on an Illumina NextSeq 500 platform.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Final", "libraries", "were", "run", "on", "an", "Illumina", "NextSeq", "500", "platform", ...
PMC9268620	In contrast to nordamnacanthal, most of the cells treated with 10 μg/mL of damnacanthal were in the early stages of apoptosis (Figure 7).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11337594	These genes represent downstream targets of the p53 signaling pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "genes", "represent", "downstream", "targets", "of", "the", "p53", "signaling", "pathway...
PMC11395280	Specifically, untreated mice survived an average of 40 ± 15.8 days compared to an average of 127.5 ± 39.0 days for mice treated with CCL198-83.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6379402	Hence, iCells capture additional functional information, which emerges from the NMTF-based fusion of the molecular networks, despite the three molecular networks having almost no overlap (Supplementary Fig. 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11585254	The BRET response was calculated as the area under the curve at each concentration of CXCL13 and normalized to 10 M CXCL13 (B/C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC8609870	At present, the commonly used treatment methods include immunotherapy, endocrine therapy and anticoagulant therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "present", ",", "the", "commonly", "used", ...
PMC11514418	Moreover, the median survival time of patients receiving the combined therapy of APS and GS was 394 days, significantly longer than that of patients receiving the monotherapy of GS alone (339 days) (hazard ratio: 0.66; 95%CI: 0.45-0.99; P = 0.036).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11672881	DESeq2 was used to compare gene expression among the groups of samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DESeq2", "was", "used", "to", "compare", "gene", "expression", "among", "the", ...
PMC8873393	It has been well known that CSB regulates the transcriptional program of coding genes both under normal conditions and after UV irradiation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", ...
PMC6222726	Cubebin was first isolated by Chatterjee in 1968 from Piper cubeba and then from several Aristolochia spp.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cubebin", "was", "first", "isolated", "by", ...
PMC9429973	The former group had similar progression-free survival (PFS) rates as well as overall survival (OS) rates and response rates (MRR and ORR) to the second-line treatment compared to their counterparts who did not achieve MRR with the frontline regimen (Table).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10522430	These results indicated that the GACP extract effectively played a protective role against cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "indicated", "that", "the", "GACP", "extract", ...
PMC7757104	Notably, in the present study, when OPNc was knocked down, OPNa and OPNb were upregulated; the indirect effects of OPNc knockdown on the expression of the two other splice variants may be explained by cellular compensation due to low OPNc levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11711871	The values are presented as the mean ± SEMs, and the data were evaluated via two-way ANOVA and subsequently compared with an unpaired two-tailed t test with Welch’s correction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594641	Therefore, the participation of Rab proteins in sEV biogenesis could be complementary and/or cell-type-dependent .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "the", "participation", "of", "Rab", "prot...
PMC9429973	It can create prerequisites for future studies regarding more effective therapeutic targets, related to both – the molecular pathways of the mutations in MPNs and the molecular mechanisms of the chronic inflammation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9250505	In contrast, animals treated with either NPB or Olaparib exhibited an initial regression and then delayed growth in xenograft volume.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ...
PMC11637276	These experiments were performed with pHrodo-labelled ECM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "experiments", "were", "performed", "with", "pHrodo-labelled", "ECM", "." ] } ]
PMC11754436	mm represent miR-362-5p mimic group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "mm", "represent", "miR-362", "-", "5p", "mimic", "group", "." ] } ]
PMC9784246	A total of 102 compounds were tentatively identified using UPLC-ESI-MS/MS analysis of the total extract and its fractions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "total", "of", "102", "compounds",...
PMC11352666	Trypsin-EDTA (Invitrogen, Thermo Fisher Scientific, Waltham, MA, USA) or mechanical dissociation with a cell scraper was used to collect adherent cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11185260	RT-qPCR analysis of transcriptional expression of genes related to ATRT progression. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RT-qPCR", "analysis", "of", "transcriptional", "expression", "of", "genes", "related",...
PMC7342409	immunohistochemical detection of caspase 7 protein expression in rat tumor tissue.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "immunohistochemical", "detection", "of", "caspase", "7", "protein", "expression", "in", "ra...
PMC9429973	Since the patient has no sibling full donor, the donor chooses the non consanguineous half matched donor sought by the bone marrow bank.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11317131

Both PE and insertion efficiency are measured using ddPCR using reverse primers found on the att site or donor plasmid, respectively. (

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PMC9739791

Prodrugs 17–26 were conjugated through a linker in the side aliphatic moiety of a pyrrole scaffold.

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PMC9429973

Aims: We aimed to investigate efficacy and safety of first line R-CPOP in DLBCL patients with significant cardiac morbidity or high risk of anthracycline induced cardiotoxicity.

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PMC5308810

Particularly in OVC, silencing CXCR4 expression by siRNA reduces tumor growth .

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PMC11594588

The full blood count is often enriched with a description of red blood cell parameters (MCV, MCH, MCHC) and platelet parameters (MPV, PDW, and pct), granulocytes, lymphocytes, eosinophils, and basophils.

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PMC11680562

Subsequently, the plates were incubated overnight in an incubator at 37 °C with 5% CO2 to promote adhesion.

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PMC8358176

Expression of CD40 reduced in MWCNT-treated (-1.01 ± 0.08) and PBS-treated (-2.03 ± 0.28) cells but increased in SWCNT-treated cells (1.75 ± 0.11; p = 0.083).

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PMC10092581

The main molecular mechanisms involved in oxaliplatin resistance appears to depend upon: (i) decreased cellular accumulation, which is thought to be related to a greater activity of the ATP7B exporter rather than to the activity of P‐glycoprotein (P‐gp) and multidrug resistance protein 1 (MRP1), and (ii) more efficient...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Moreover, LC-MBL showed overexpression of genes implicated in antigen processing and presentation and OXPHOS compared to either HC-MBL or CLL.

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PMC11407042

A549 cell line culture medium Alternatives: 1% antibiotics (50 U/mL of penicillin-streptomycin) can be added to prevent contamination.

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PMC9429973

Thyroid gland involvement is rare, and solitary thyroid gland involvement with LCH is extremely rare, with most cases presenting as part of multisystem disease.

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PMC9429973

For NSC23766 only, the presence of NPM1 mutation was associated with more severe apoptosis and necrosis (p=0.01).

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PMC11367146

Notably, there is a consistent region between residues 28–80 where the plot remains constant, indicating a missing or disordered structure contributing to instability.

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PMC9621239

β-actin was used as a loading control.

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PMC10891340

In the uninfected group, it can be observed that the degradation of MFN2 was induced by the CCCP treatment.

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PMC11695623

The diagnostic and prognostic value of DCUN1D5 in patients with LUAD was analyzed by TCGA, GEPIA and Kaplan–Meier Plotter database.

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PMC9429973

The Sequenom MassArray system (Sequenom, San Diego, CA) was used to detect three SNPs genotypes in the HIF1A gene: rs11549465, rs1957757 and rs2057482.

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PMC11635087

We conducted an imaging PAM analysis to measure the effective quantum yield (φII) of the chloroplasts in CHO-K1 cells at 0, 2, and 4 days after the co-cultivation (Fig. 6).

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PMC11730320

The variant was validated by PCR and Sanger sequencing and correctly segregated in the nuclear family.

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PMC9429973

Broad-spectrum azoles and echinocandin can be used as prophylaxis in patients receiving new targeted therapies.

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PMC11788920

The achieved suppression and activation in Burkitt’s Lymphoma cell line and in in vitro studies are at or beyond those reported with alternative approaches.

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PMC9429973

The in vitro assays with MM cell lines showed that the SCFAs acetate, butyrate and propionate had an antiproliferative effect (Fig. 1E).

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PMC10380508

Metastasis and recurrence are common in RCC patients, leading to poor clinical outcomes.

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PMC11700165

Upon stimulation these kinases translocate from the cytoplasm to the nucleus.

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PMC11591038

The main components of the tumor microenvironment include blood vessels, lymphatic vessels, extracellular matrix, various immune cells, and fibroblasts .

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PMC11637716

Furthermore, these variants were not listed in the ClinVar and LOVD databases at the time of the study.

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PMC11711871

Overall, both GR rat models developed salt-sensitive hypertension, although they had different predispositions to standard diet, namely, hypercorticosteronemia in GR and normal plasma corticosteroid levels in GR rats.

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PMC9429973

L. Minarik, T. Stopka, Z. Zemanova, A. Jonasova Clinic of Hematology, General University Hospital and First Faculty of Medicine, Charles University, Prague; 1st Faculty of Medicine, BIOCEV, Vestec; Center of Oncocytogenomics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and ...

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PMC11670954

Our findings corroborate those of previous studies investigating the beneficial effects of BA on cellular viability and the modulation of tight junction protein expression in epithelial cells.

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PMC9429973

Results: We showed that full APEX1 KO HSPCs failed to repopulate irradiated recipient mice.

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PMC7823217

Cervical cancer is divided into two main subtypes namely squamous cell carcinoma and adenocarcinoma that account for 70% and 25% cervical cancer cases, respectively .

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PMC10203589

For most countries, the diagnosis is usually too late for radical treatment due to the lack of a good system in terms of diagnostic and screening methods (40–42).

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PMC11634794

Consequently, we propose the existence of a regulatory pathway involving VHL-LC3C-LAMP1 in ccRCC.

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PMC8389560

The study of these mechanisms is important for understanding the cytotoxic effect of selenium nanoparticles and the role of this microelement in the regulation of carcinogenesis.

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PMC11637276

Cells were then incubated with the respective primary antibodies for 1 h at room temperature.

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PMC9504875

We investigated whether and how nairoviruses antagonize host innate immunity using Hazara orthonairovirus (HAZV) as a surrogate model for Crimean-Congo hemorrhagic fever virus.

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PMC11216402

Because we do not have an independent metric to assess the quality of the RNA-seq, we weighted the ATAC-seq more heavily for SNU484 and labelled it Epi-like.

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PMC11791264

∗p < 0.05, ∗∗p < 0.01 (Two-way ANOVA followed by Tukey’s multiple comparison).

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PMC9429973

Methods: Pts with ≥6 mo of data, or pts who discontinued the study prior to Month 6 were included.

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PMC10033453

Interpolated time point at which 50% of maximal cell death occurs at each MOI of VMG from the data in (A). (

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PMC11770746

Interestingly, the platinum levels in the tumor for cisplatin, coadministration of cisplatin and paclitaxel, and cisPt(Pac)(OH) were rather similar, reinforcing the indication that for effective inhibition of the tumor growth, both cisplatin and paclitaxel need to accumulate in the tumor.

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PMC11637276

To confirm the relevance of this process to different cancer types, A2780-Rab25 cells were treated with 50 μM SB203580 or siRNAs against MAP3K1, MAPK11, PPP2R1A, and α2 integrin and seeded on CDM.

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PMC11792766

The EFSA guidelines involve the Ames test and the in vitro micronucleus assay as tools for the mandatory assessment of the genotoxic potential of food contact chemicals.

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PMC4355729

Briefly, 4 × 10 cells were seeded into a 24 well plate.

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PMC11592008

The main aim of this study was to identify the most suitable in vitro model for analyzing inflammasome signaling in keratinocytes by comparing PKs with three immortalized keratinocyte cell lines—HaCaT, HaSKpw, and SVTERT—in terms of inflammasome activation and detection.

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PMC11679326

Thus, a high level of paucimannosylation in U-87 MG and U-138 MG glioblastoma cell lines with a predominant glycan structure Man3GlcNAc2Fuc, which consists of a naked trimannosyl core and a fucosylated N-acetylglucosamine residue in the chitobiose core and is processed by the enzymes α-mannosidases 2 from the MAN2 fami...

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PMC11787651

A, number of peptides identified by EpiProfile 2.2 in three biological replicates analyzed with the 55-min nanoflow gradient on the Orbitrap Exploris or the 5- or 10-min microflow gradient on the ZenoTOF.

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PMC11653168

To assess the cytotoxic effects of Stattic on T-ALL cells, CCRF-CEM (Fig. 1A) and Jurkat cells (Fig. 1B) were treated with increasing concentrations of Stattic (0.625, 1.25, 2.5, 5 and 10 µM) or vehicle control (DMSO) for 24 h. Cell viability was measured using the CCK-8 assay.

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PMC9429973

More studies should be done on the current matter with adjustments for confounding variables.

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PMC8494202

Then, cDNA was reverse transcribed from total RNA using NovoScript Plus All-in-one 1st Strand cDNA Synthesis SuperMix (Novoprotein, Shanghai, China).

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PMC11703992

B The MR analysis process of ARHGAP15.

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PMC11673128

In this setting, immunotherapy could be a feasible approach since ALK peptides are known to be immunogenic and able to elicit a robust adaptive immune response in patients .

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PMC9739791

To confirm that upon light-induced activation with riboflavin Pt(IV) prodrugs release species that could bind with DNA, the formation of DNA cross-links was studied by circle dichroism (CD) and MALDI-TOF spectra.

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PMC9429973

The control group received conventional symptomatic treatment, while the test group was treated with LLLT in addition to the symptomatic treatment.

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PMC9436459

As outlined in Scheme 2, the authors started the preparation of the chalcone dienophile S3 from ketone S1 and aldehyde S2 via Claisen-Schmidt condensation.

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PMC11412752

Additionally, while STING expression is not detected in mouse and human primary hepatocytes, it is expressed and functional in HepG2 cells .

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PMC11307990

The agarose gel electrophoresis image illustrated the stability of 6HB-DONs and DNA nanotapes in the 1640 medium with 10% FBS for 24–72 h at 37 °C.

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PMC10674574

Furthermore, to establish transport conditions through the Caco-2 monolayer, preliminary experiments can be performed only in one direction (B–A) in a transport buffer at a pH of 7.4 .

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PMC8170755

The cells were detached from the old culture using 0.25 mg/mL trypsin/EDTA (Invitrogen).

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PMC6450504

At pH 5.0, release from PEIPOS was faster than that at neutral pH. Together, the behavior of PEIPOS in both pH conditions, lead to the conclusion that the PEIPOS can retain the majority of the hydrophobic drug in an environment that resembles the circulation and upon reaching the tumor microenvironment, and particularl...

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PMC9910796

Similar to most retroviral Gag precursors, pp220 uses N-myristoylation to facilitate membrane binding.

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PMC9429973

So, 108 genes directly related to the downstream signaling of eltrombopag, cytokine signaling pathways, cytotoxic pathways, growth factors, adhesion molecules, apoptotic mechanisms and physiological mechanisms of platelet production are analyzed in peripheral blood from 35 refractory and 35 controls who responded to th...

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PMC11655498

Recent studies have successfully isolated human extrachromosomal DNAs using CRISPR-CATCH (Hung et al., 2022).

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PMC11770130

Many chemicals have more than one target in vivo.

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PMC11748335

This suggests that long LOCKs relate to the inhibition of the expression of genes and OGs within their vicinity.

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PMC11733919

Physico-chemical characterization of the nanoplatform. (

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PMC9429973

CR rates were consistent in patients with and without prior CAR-Ts (32% vs 37%).

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PMC8427838

p < 0.001 Knockout of moesin in 786-0 cells inhibits TMIGD1-dependent α-tubulin acetylation and F-actin orientation.

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PMC7039683

Under a dissecting microscope, the epithelium was isolated for ATAC-seq by gently peeling using microforceps.

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PMC10158546

We also observed increased abundance of PRNP mRNA throughout differentiation in both ReN WT and empty cells, but not 129 M cells (Figure 3d).

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PMC11701801

This indicates that KREMEN2 expression could be increased by cBAF deficiency induced by SS18–SSX fusion.

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PMC11248911

The sulfur atom representing the zinc binding group interacted with the Zn ion, Tyr381 and His301 amino acids of the enzyme, while the NH group formed H-bond interaction with Ala262, also the phenyl ring interacted with Met263 amino acid.

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PMC9429973

Image: Summary/Conclusion: After >2 years of follow-up, asciminib continued to show clinically and statistically significant, superior efficacy and better safety/tolerability vs BOS.

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PMC11707832

The link between MAN2B1 and mannosidosis has been reviewed elsewhere .

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PMC8009078

Hence, the MM-GBSA was used to calculate the binding free energy (∆Gbind) of the TMPRSS2 inhibitors.

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PMC9429973

Final libraries were run on an Illumina NextSeq 500 platform.

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PMC9268620

In contrast to nordamnacanthal, most of the cells treated with 10 μg/mL of damnacanthal were in the early stages of apoptosis (Figure 7).

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PMC11337594

These genes represent downstream targets of the p53 signaling pathway.

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PMC11395280

Specifically, untreated mice survived an average of 40 ± 15.8 days compared to an average of 127.5 ± 39.0 days for mice treated with CCL198-83.

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PMC6379402

Hence, iCells capture additional functional information, which emerges from the NMTF-based fusion of the molecular networks, despite the three molecular networks having almost no overlap (Supplementary Fig. 4).

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PMC11585254

The BRET response was calculated as the area under the curve at each concentration of CXCL13 and normalized to 10 M CXCL13 (B/C).

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PMC8609870

At present, the commonly used treatment methods include immunotherapy, endocrine therapy and anticoagulant therapy.

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PMC11514418

Moreover, the median survival time of patients receiving the combined therapy of APS and GS was 394 days, significantly longer than that of patients receiving the monotherapy of GS alone (339 days) (hazard ratio: 0.66; 95%CI: 0.45-0.99; P = 0.036).

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PMC11672881

DESeq2 was used to compare gene expression among the groups of samples.

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PMC8873393

It has been well known that CSB regulates the transcriptional program of coding genes both under normal conditions and after UV irradiation .

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PMC6222726

Cubebin was first isolated by Chatterjee in 1968 from Piper cubeba and then from several Aristolochia spp.

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PMC9429973

The former group had similar progression-free survival (PFS) rates as well as overall survival (OS) rates and response rates (MRR and ORR) to the second-line treatment compared to their counterparts who did not achieve MRR with the frontline regimen (Table).

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PMC10522430

These results indicated that the GACP extract effectively played a protective role against cancer.

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PMC7757104

Notably, in the present study, when OPNc was knocked down, OPNa and OPNb were upregulated; the indirect effects of OPNc knockdown on the expression of the two other splice variants may be explained by cellular compensation due to low OPNc levels.

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PMC11711871

The values are presented as the mean ± SEMs, and the data were evaluated via two-way ANOVA and subsequently compared with an unpaired two-tailed t test with Welch’s correction.

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PMC11594641

Therefore, the participation of Rab proteins in sEV biogenesis could be complementary and/or cell-type-dependent .

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PMC9429973

It can create prerequisites for future studies regarding more effective therapeutic targets, related to both – the molecular pathways of the mutations in MPNs and the molecular mechanisms of the chronic inflammation.

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PMC9250505

In contrast, animals treated with either NPB or Olaparib exhibited an initial regression and then delayed growth in xenograft volume.

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PMC11637276

These experiments were performed with pHrodo-labelled ECM.

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PMC11754436

mm represent miR-362-5p mimic group.

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PMC9784246

A total of 102 compounds were tentatively identified using UPLC-ESI-MS/MS analysis of the total extract and its fractions.

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PMC11352666

Trypsin-EDTA (Invitrogen, Thermo Fisher Scientific, Waltham, MA, USA) or mechanical dissociation with a cell scraper was used to collect adherent cell lines.

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PMC11185260

RT-qPCR analysis of transcriptional expression of genes related to ATRT progression. *

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PMC7342409

immunohistochemical detection of caspase 7 protein expression in rat tumor tissue.

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PMC9429973

Since the patient has no sibling full donor, the donor chooses the non consanguineous half matched donor sought by the bone marrow bank.

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