OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11186948	More recently a patient clinically diagnosed as CdLS who resulted positive for a de novo variant in HDAC2 by exome sequencing: c.93G > A; p.(M31I) was described (Wagner et al. 2019).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6600253	Recent studies have indicated that RSV prodrugs could serve as an alternatives to increase RSV bioavailability .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recent", "studies", "have", "indicated", "that", "RSV"...
PMC5673955	Peripheral blood mononuclear cells (PBMC) were isolated using Lympholite‐H (Cedarlane, Burlington, Ontario, Canada) density gradient centrifugation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Periphe...
PMC10631132	For example, Sturgeon et al. showed that activation of Wnt–β-catenin during mesodermal specification can determine whether cells will undergo a definitive hematopoietic program [58–60] or a primitive program.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11625890	What are the potential implications of this finding for your field of research?	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "What", "are", "the", "potential", "implications", "of", "this", "finding", ...
PMC11568601	A The knockdown efficiency of three siIRE1s was measured via a western blot experiment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "The", "knockdown", "efficiency", "of", "three", "siIRE1s", ...
PMC11543885	Image the plate on a high-content laser-based spinning disk confocal microscope (Opera Phenix Plus, Revvity), using a 60× water objective.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10745221	Methylation of RNA at adenosine bases leads to N6-methyladenosine (m6a), which is recognized by “reader” proteins, promoting translation of the mRNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11291490	Statistical significance was assessed using an unpaired Student’s t-test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "significance", "was", "assessed", "using", "an", "unpaired", "Student", "’s", "t-...
PMC11711871	The values are presented as the mean ± SEMs, and the data were evaluated via two-way ANOVA and subsequently compared with an unpaired two-tailed t test with Welch’s correction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5363531	These results suggest that even the less PEM-sensitive MPM cell lines, such as REN and MPP89, can be sensitized by the co-administration of dasatinib.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11320834	The most notable example is the rare high-penetrant mutations in the BRCA1 and BRCA2 genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "most", "notable", "example", "is", "the", "rare", ...
PMC11593031	Both were created by introducing a thyroid hormone receptor subunit into the genome of Neuro-2a: in the case of Neuro-2a TR-alpha, the α1 subunit of the thyroid hormone receptor, and in Neuro-2a TR-beta, the β1 subunit had a consecutive overexpression of α1 or β1 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "...
PMC11529598	Written inform consent was obtained from each patient and study plan was approved by Ethics Committee of General Hospital of Northern Theater Command.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Written...
PMC11361748	Acet, acetone; n, nucleus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Acet", ",", "acetone", ";", "n", ",", "nucleus", "." ] } ]
PMC11078693	Note: If high quality bright-field imaging is required, the chamber should be slightly over-filled with PBS, which requires about 4 mL of PBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11694066	This was further accompanied by a concentration-dependent increase in PD-L1 cell-surface expression, as assessed by flow cytometry (Fig. 6D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "was"...
PMC11291490	Subsequently, the plates were washed five times with PBS-T. HRP-conjugated goat anti-duck IgG (Cat# 5220-0296, KPL, USA), diluted at 1:2000, was added to the plates (100 μL/well) for 1 h at 37 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: We investigated SNPs of five cytokine genes [tumour necrosis factor (TNF)-alpha, interferon (IFN)-gamma, transforming growth factor (TGF)-beta, interleukin (IL)-6 and IL-10] in 72 Italian warm AIHA patients, using the Cytokine Tray (One Lambda, Canoga Park, CA) according to the manufacturer’s recommendations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7642379	However, when evaluating the expression of common markers for mesenchymal and endothelial phenotypes as well as predicting the outcome of the EMT pathway using IPA, the parental HEK293 strain showed the most mesenchymal-like phenotype whereas suspension cell lines were predicted to have reduced transition from epitheli...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11761919	A recently published report showed that chitosan derivatives chemically modified with phthalic anhydride did not display toxicity in human fibroblast cells (Sousa et al., 2024), indicating phthalic anhydride is saftey and compatible for use as biomaterials in chemical modification.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9219615	The JC-1 dye enters and accumulates in functional mitochondria to form red fluorescent complexes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "JC-1", "dye", "enters", "and", "accumulates", "in", "func...
PMC11731161	Based on these results, we hypothesize that the downregulation of XPO1 protein induced by SEL plays a crucial role in influencing drug sensitivity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11481779	The key concept there was to first use encoder, that takes 1D DNA sequence and processes it into hidden representation using 1D convolutions, and then decoder,, which then operates on 2D heatmaps (with addition of hidden dimensions).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11772449	UALCAN (http://ualcan.path.uab.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "UALCAN", "(", "http://ualcan.path.uab", "." ] } ]
PMC11719944	Our findings are presented in Figure 5a–p. Overall, we did not observe significant differences in the memory T cell compartment, except for an increase in the naive CD4+ T cell subpopulation in the T1D patient group compared to healthy individuals (82.18 ± 49.02 vs. 65.69 ± 36.32 cells/μL).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10891340	A and B) The control group and the infected group were treated with DMSO and CCCP respectively at 8 hpi (A) and 24 hpi (B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5363531	Conversely, pSRC was differentially detected being localized in the cytoplasm of MSTO cells and almost exclusively in the nucleus of MPP89 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens"...
PMC11033180	One limitation of this study is the lack of in vivo evidence that Sema5A regulates enteric neuron connectivity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "limitation", "of", "this", "stu...
PMC8633974	Z-stack affirmed that the CRISPR reached the nucleus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Z-stack", "affirmed", "that", "the", "CRISPR", "reached", "the", "nucleus", "." ] } ]
PMC9429973	Summary/Conclusion: Our findings indicate PI3Ki drug class activity in idelalisib-refractory CLL, and suggest that ex vivo drug sensitivity may guide precision medicine and predict treatment responses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7171147	A2780 and A2780cis ovarian cancer cell lines were purchased from SIGMA.	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A2780", "and", "A2780cis", "ovarian", "cancer", "cell", "lines", "were", ...
PMC11682172	Total numbers of proteins measured in the cancer cell lines prior to, and incubation with activated T lymphocytes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Total", "numbers", "of", "protein...
PMC11774747	Specific lysis rates can vary, but highly enhanced killing compared to non-transduced VST or those targeting irrelevant antigens is consistent.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Specific", "lysis", ...
PMC8875242	The accumulation of [H]-digoxin was stopped after 2 h of incubation by washing the slices twice in the Krebs–Henseleit cold buffer (4 °C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Summary/Conclusion: The number of genes analysed in the context of CLL amongst laboratories was highly variable.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "The", "number", "of", ...
PMC9368503	Proteomic profiles of the three synovial sarcoma cell lines and FFPE tissue samples were analysed by significance analysis of microarrays (SAM) using the samR package in R. For this, the log2 transformed and quantile normalised dataset was used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740508	G2/M stalling suggests that combination therapeutic treatment potentiates DNA damage, and that cells may be attempting DNA repair by inaccurate mechanisms available to cells with compromised HRR (review: ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11532793	For transcripts with very low counts, the traditional chi-square approximation to the NB deviances is biased and results in underestimation of the quasi-dispersions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11437637	Although the exact cause of EC is unknown, obesity, hypertension, and diabetes are three high-risk factors, and comprehensive staged surgery is its main treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6102174	The following bioassay-guided isolation gave rise to 47 compounds, involving 29 new and 13 active ones.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "following", "bioassay-guided", "isolation", ...
PMC11320084	Thus, A427 and A549 cells were selected for subsequent study.	[ { "tags": [ "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "A427", "and", "A549", "cells", "were", "selected", "for", ...
PMC11401358	Observations of ROS scavenging in NIH3T3 cells with different polymers using confocal microscopy (Scale bar = 100 μm). (	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Observations", ...
PMC11509224	Of the 228 molecules, 110 exhibit cytotoxic, antibacterial, antifungal, antiparasitic, anti-inflammatory, and antifouling activities, among others.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Of", ...
PMC9878278	These IFNs induce several interferon-stimulated genes (ISGs) including MxA, IFIT1, and PRRs like RIG-I and TLR3 that collectively generate an antiviral state in neighboring uninfected cells and block viral replication in infected cells (Schoggins and Rice, 2011).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10589262	Quantification of immunofluorescence intensity further demonstrated that GRB2 and P85 colocalize with MT-KIT and GM130 at the Golgi complex (Supplementary Fig. S7).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10317042	Consistent with a previous study, we found that HDACi treatment decreases the expression of EWSR1::ATF1 in CCS cells, and we focused on elucidating the underlying suppression mechanism, which would facilitate the development of fusion gene–targeted therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6133382	Single-stranded DNA oligonucleotides and their complement strands were synthesized (Eurofins Genomics, Louisville, KY, US) with extra bases on the 3′ ends for ligation into a GeneArt CRISPR nuclease vector (Thermo Fisher, GeneArt, Waltham, MA, US).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11252553	treated with Taurine (100 µg.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "treated", "with", "Taurine", "(", "100", "µg", "." ] } ]
PMC9341513	The FISH and simulation data generated in this study have been submitted to the Edinburgh DataShare repository (https://datashare.ed.ac.uk/handle/10283/4433).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "FISH", "and", "...
PMC9429973	NTRK3 expression was also strongly upregulated, suggesting a possible rationale for specific inhibitors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NTRK3", "expression", "was", "also", "strongly", "upregulated", ",", ...
PMC5854676	The values for the slopes and y-intercepts were calculated using the least squares method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "values", "for", "the", "slopes", "and", "y-intercepts", "...
PMC9424261	As shown in Fig. 2A, compared with the control group, after CA treatment, we screened out three co-upregulated genes, namely HERPUD1, 3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1), growth differentiation factor 15 (GDF15) through transcriptome sequencing technology and tandem mass tags (TMT).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11731161	The data are expressed as mean ± SD. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "data", "are", "expressed", "as", "mean", "±", "SD", ".", "*" ] } ]
PMC11515150	Moreover, both VHHs with 6×His tag or Fc tag competed with each other for binding to Jurkat cells by flow cytometry (Fig. 1e).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	As genetic alterations in RPs drive anemia in Diamond-Blackfan anemia and myelodysplastic syndromes with chromosome 5q deletions, we evaluated eIF5A hypusination in different models of these bone marrow failure syndromes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	A connection between PPP inhibition and changed immune profile by modulation of the Stat1-Irg1-itaconate axis was identified and validated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "connection", "between", "PPP...
PMC11748335	For instance, H3K9me3 is often associated with heterochromatin and is typically found along the nuclear periphery .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "instance", ",", "H3K9me3", "is", "of...
PMC10253553	The decrease in RICTOR was associated with a statistically significant reduction in total NDRG1 protein (by ~50%) and phosphorylated NDRG1 (on Thr346) (between ~30 and 50%, for Ri #1 and Ri #2, respectively) relative to cells transfected with NT siRNA (Figure 2B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11365427	This indicates that ATF3 expression directly activates DR5 transcription.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "indicates", "that", "ATF3", "expression", "directly", "activates", "DR5", "transcription", "." ...
PMC11474209	Excessive phosphorylation of p53 may trigger apoptosis by disrupting mitochondria, phosphorylating mitogen-activated protein kinases MAPKs to modify the cytoskeleton, and phosphorylating CaMKII to produce ROS species.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9024365	Cells were cultured at 37C with 5% CO2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "cultured", "at", "37C", "with", "5", "%", "CO2", "." ] } ]
PMC11792766	This includes both conventional cytotoxicity and cell viability assays and regulatory mutagenicity and genotoxicity assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "includes", "both", "conventional", "cytotoxicity", "and",...
PMC11321678	However, the binding motif of NEUROD2 is only active in C2‐C5.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "binding", "motif", "of", "NEUROD2", "is", "only", "...
PMC11078693	Increase the g-force of centrifugation staying below 1000 g when spinning the cells down to attach them to the cover glass.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Increase", "the", ...
PMC10380508	Finally, protein detection was performed by incubating the membrane in freshly prepared SuperSignal West Pico Chemiluminescent Substrate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "protein", "detection", ...
PMC9429973	Methods: Using flow cytometry, we sub-classified HSCs by combining “classic” HSC markers (CD150CD48LSK) with EMCN into EMCN HSCs and EMCN HSCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11634027	Cross-vein spacing was calculated by tracing the length of vein L4 between cross-veins, divided by the length of vein L3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cross-vein", "spacing",...
PMC9436459	All ketalized MDAAs were reported as cis–trans configuration based on the coupling constants of H-4" with H-3" and H-5" (small J3"/4" and large J4"/5").	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11423992	Collectively, these findings provided compelling evidence that TFAB002s as a novel class of tumor-targeted bispecific antibodies had promising antitumor efficacy and acceptable safety.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11604015	Another category of CAR-T cells includes autologous and allogeneic CAR-T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Another", "category", "of", "CAR-T", "cells", "includes", "autologous", "and", "allogeneic"...
PMC10890055	The prepared samples were transferred to MEM or DMEM/Ham’s F-12 cultivation medium with 5% fetal bovine serum (FBS) and agitated (130 RPM) at 37 °C in closed vessels for 24 h. The surface-to-volume ratio was 87.5 mm·mL for all samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11763126	These results collectively suggest that CBDP1 inhibits ccRCC proliferation and metastasis by downregulating TRPM3 expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "collectively", "suggest", "that", "CBDP1", ...
PMC6889484	These substitutions were previously shown to have a minimal effect on virus replication.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "substitutions", "were", "previously", "shown", "to", "have", "a", ...
PMC11285179	Cluster 14, which was CSPG4 and ACTA2, was recognized as pericytes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cluster", "14", ",", "which", "was", "CSPG4", "and", "ACTA2", ",", ...
PMC9545714	In this situation, the ultrastructure of the intercellular spaces of the stratum is altered, and the TEWL is markedly elevated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this",...
PMC11424574	Our results show that treatment with recombinant uPA (Rh-uPA) protein increased osteosarcoma cell migration (HOS cells, 298.5% increase; 143B cells, 234.2% increase) and cell invasive ability (HOS cells, 220.2% increase; 143B cells, 204.1% increase), compared with shLuc-OS cells (Figure 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "...
PMC9429973	Hence, cells have developed a variety of mechanisms to protect genome integrity and repair damaged DNA, collectively termed the DNA damage response (DDR).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	100% ORR and 100% MRD negative rate, along with favorable safety evidenced support OriCAR-017 could be a competitive therapy for pts with R/RMM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11394730	In a comparative study of ten polyphenols, including caffeic acid (CA), gallic acid (GA), catechin (C), epicatechin (EC), and their derivatives, EGCG exhibited a solid ability to induce apoptosis and cause G1 phase cell cycle arrest in cancer cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11723947	a, c Representative dot-plots showing the frequency of syngeneic (H-2K) and semi-allogeneic (H-2K) cells in the blood 21 days after engraftment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11216402	We discovered a similar pattern of enrichment comparing TCGA-STAD and normal tissues with the cell lines (Fig. 2D, which is gene set enrichment analysis on PC2 of Fig. 2B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8068766	Fifteen DEGs with high betweenness centrality values were identified by the PCST analysis for the between cell line comparison results, and eleven of these genes were Steiner nodes which were not differentially expressed but were determined to be on key positions on pathways that might have effects on the expression of...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Although prior studies have described an exhausted and pro-tumor T cell state, there may be potential to stimulate anti-CLL cytolytic T cell activity with novel therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740907	A comparison was made between the findings and the standard that had been set for cisplatin effectiveness.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "comparison", "was", "made", "between", ...
PMC11243198	Based on the calculated chemical properties (Table 2), BAS 07019774 (pyridin-4-ylmethyl-(4-pyrrolidin-1-yl-phenyl)-amine) meets the criteria of Lipinski’s rule of five (mol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The cell concentration in the frozen suspension ranged between 69х10/ml and 665х10/ml (median 310,25х10/ml).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cell", "concentration", "in", "the", "frozen", ...
PMC11770130	In the previous study, we performed an AAV injection-based experiment to validate the anti-thermogenic effects of NTS in BATs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "previous", ...
PMC9429973	Aims: We aimed to formally investigate safety and efficacy of nivolumab and RT in r/r HL failing anti-PD1 treatment in a proof-of-concept study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9812014	In the in vivo studies, HHT was efficient at suppressing PEDV viral production in piglets and hens at doses of 0.05 mg/kg and 0.2 mg/kg, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11401358	Statistical analysis of ROS levels in b. ****P < 0.0001, NS, no significance, t-test, data represent the mean ± standard deviation (SD).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11635519	A P value of less than 0.05 was considered to be statistically significant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "P", "value", "of", "less", "than", "0.05", "was", "considered", ...
PMC7840816	A value of p < 0.05 was considered to indicate a statistically significant result.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "value", "of", "p", "<", "0.05", "was", "considered", ...
PMC11672142	The n → π* absorbance at 385 nm (ε = 16,500 M cm based on ligand concentration) increases due to Fe(III) coordination (ε = 21,600 M cm based on ligand concentration).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11401358	NIH 3T3 cells (5 × 10) were seeded overnight on pretreated 6-well plates.	[ { "tags": [ "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NIH", "3T3", "cells", "(", "5", "×", "10"...
PMC11745823	The results indicate that RIT1 suppression diminishes cellular proliferation in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "indicate", "that", "RIT1", "suppression", "diminishes", "cellular", "prol...
PMC11402217	In contrast, mice treated with MTX demonstrated an appreciable increase in bone mass compared to the model group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",", "mice", ...
PMC11740907	An emptied aluminum pan served as a reference.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "emptied", "aluminum", "pan", "served", "as", "a", "reference", "." ] } ]
PMC9429973	Results: In the survey part, all 64 participating physicians opted not to perform a repeat biopsy in at least one clinical case scenario.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10604092	The SLC-transplanted rats had >2-fold higher serum levels of fibroblast growth factor 21 (FGF21), insulin-like growth factor-binding protein 3, IL-1β, IL-10, neutrophil gelatinase-associated lipocalin (NGAL), plasminogen activator inhibitor type 1 (PAI-1), tumor necrosis factor alpha (TNF-α), and vascular endothelial g...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11186948

More recently a patient clinically diagnosed as CdLS who resulted positive for a de novo variant in HDAC2 by exome sequencing: c.93G > A; p.(M31I) was described (Wagner et al. 2019).

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PMC6600253

Recent studies have indicated that RSV prodrugs could serve as an alternatives to increase RSV bioavailability .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recent", "studies", "have", "indicated", "that", "RSV"...

PMC5673955

Peripheral blood mononuclear cells (PBMC) were isolated using Lympholite‐H (Cedarlane, Burlington, Ontario, Canada) density gradient centrifugation.

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PMC10631132

For example, Sturgeon et al. showed that activation of Wnt–β-catenin during mesodermal specification can determine whether cells will undergo a definitive hematopoietic program [58–60] or a primitive program.

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PMC11625890

What are the potential implications of this finding for your field of research?

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PMC11568601

A The knockdown efficiency of three siIRE1s was measured via a western blot experiment.

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PMC11543885

Image the plate on a high-content laser-based spinning disk confocal microscope (Opera Phenix Plus, Revvity), using a 60× water objective.

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PMC10745221

Methylation of RNA at adenosine bases leads to N6-methyladenosine (m6a), which is recognized by “reader” proteins, promoting translation of the mRNA.

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PMC11291490

Statistical significance was assessed using an unpaired Student’s t-test.

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PMC11711871

The values are presented as the mean ± SEMs, and the data were evaluated via two-way ANOVA and subsequently compared with an unpaired two-tailed t test with Welch’s correction.

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PMC5363531

These results suggest that even the less PEM-sensitive MPM cell lines, such as REN and MPP89, can be sensitized by the co-administration of dasatinib.

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PMC11320834

The most notable example is the rare high-penetrant mutations in the BRCA1 and BRCA2 genes.

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PMC11593031

Both were created by introducing a thyroid hormone receptor subunit into the genome of Neuro-2a: in the case of Neuro-2a TR-alpha, the α1 subunit of the thyroid hormone receptor, and in Neuro-2a TR-beta, the β1 subunit had a consecutive overexpression of α1 or β1 .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "...

PMC11529598

Written inform consent was obtained from each patient and study plan was approved by Ethics Committee of General Hospital of Northern Theater Command.

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PMC11361748

Acet, acetone; n, nucleus.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Acet", ",", "acetone", ";", "n", ",", "nucleus", "." ] } ]

PMC11078693

Note: If high quality bright-field imaging is required, the chamber should be slightly over-filled with PBS, which requires about 4 mL of PBS.

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PMC11694066

This was further accompanied by a concentration-dependent increase in PD-L1 cell-surface expression, as assessed by flow cytometry (Fig. 6D).

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PMC11291490

Subsequently, the plates were washed five times with PBS-T. HRP-conjugated goat anti-duck IgG (Cat# 5220-0296, KPL, USA), diluted at 1:2000, was added to the plates (100 μL/well) for 1 h at 37 °C.

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PMC9429973

Methods: We investigated SNPs of five cytokine genes [tumour necrosis factor (TNF)-alpha, interferon (IFN)-gamma, transforming growth factor (TGF)-beta, interleukin (IL)-6 and IL-10] in 72 Italian warm AIHA patients, using the Cytokine Tray (One Lambda, Canoga Park, CA) according to the manufacturer’s recommendations.

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PMC7642379

However, when evaluating the expression of common markers for mesenchymal and endothelial phenotypes as well as predicting the outcome of the EMT pathway using IPA, the parental HEK293 strain showed the most mesenchymal-like phenotype whereas suspension cell lines were predicted to have reduced transition from epitheli...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11761919

A recently published report showed that chitosan derivatives chemically modified with phthalic anhydride did not display toxicity in human fibroblast cells (Sousa et al., 2024), indicating phthalic anhydride is saftey and compatible for use as biomaterials in chemical modification.

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PMC9219615

The JC-1 dye enters and accumulates in functional mitochondria to form red fluorescent complexes.

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PMC11731161

Based on these results, we hypothesize that the downregulation of XPO1 protein induced by SEL plays a crucial role in influencing drug sensitivity.

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PMC11481779

The key concept there was to first use encoder, that takes 1D DNA sequence and processes it into hidden representation using 1D convolutions, and then decoder,, which then operates on 2D heatmaps (with addition of hidden dimensions).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11772449

UALCAN (http://ualcan.path.uab.

[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "UALCAN", "(", "http://ualcan.path.uab", "." ] } ]

PMC11719944

Our findings are presented in Figure 5a–p. Overall, we did not observe significant differences in the memory T cell compartment, except for an increase in the naive CD4+ T cell subpopulation in the T1D patient group compared to healthy individuals (82.18 ± 49.02 vs. 65.69 ± 36.32 cells/μL).

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PMC10891340

A and B) The control group and the infected group were treated with DMSO and CCCP respectively at 8 hpi (A) and 24 hpi (B).

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PMC5363531

Conversely, pSRC was differentially detected being localized in the cytoplasm of MSTO cells and almost exclusively in the nucleus of MPP89 cells.

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PMC11033180

One limitation of this study is the lack of in vivo evidence that Sema5A regulates enteric neuron connectivity.

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PMC8633974

Z-stack affirmed that the CRISPR reached the nucleus.

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PMC9429973

Summary/Conclusion: Our findings indicate PI3Ki drug class activity in idelalisib-refractory CLL, and suggest that ex vivo drug sensitivity may guide precision medicine and predict treatment responses.

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PMC7171147

A2780 and A2780cis ovarian cancer cell lines were purchased from SIGMA.

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PMC11682172

Total numbers of proteins measured in the cancer cell lines prior to, and incubation with activated T lymphocytes.

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PMC11774747

Specific lysis rates can vary, but highly enhanced killing compared to non-transduced VST or those targeting irrelevant antigens is consistent.

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PMC8875242

The accumulation of [H]-digoxin was stopped after 2 h of incubation by washing the slices twice in the Krebs–Henseleit cold buffer (4 °C).

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PMC9429973

Summary/Conclusion: The number of genes analysed in the context of CLL amongst laboratories was highly variable.

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PMC9368503

Proteomic profiles of the three synovial sarcoma cell lines and FFPE tissue samples were analysed by significance analysis of microarrays (SAM) using the samR package in R. For this, the log2 transformed and quantile normalised dataset was used.

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PMC11740508

G2/M stalling suggests that combination therapeutic treatment potentiates DNA damage, and that cells may be attempting DNA repair by inaccurate mechanisms available to cells with compromised HRR (review: ).

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PMC11532793

For transcripts with very low counts, the traditional chi-square approximation to the NB deviances is biased and results in underestimation of the quasi-dispersions.

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PMC11437637

Although the exact cause of EC is unknown, obesity, hypertension, and diabetes are three high-risk factors, and comprehensive staged surgery is its main treatment.

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PMC6102174

The following bioassay-guided isolation gave rise to 47 compounds, involving 29 new and 13 active ones.

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PMC11320084

Thus, A427 and A549 cells were selected for subsequent study.

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PMC11401358

Observations of ROS scavenging in NIH3T3 cells with different polymers using confocal microscopy (Scale bar = 100 μm). (

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PMC11509224

Of the 228 molecules, 110 exhibit cytotoxic, antibacterial, antifungal, antiparasitic, anti-inflammatory, and antifouling activities, among others.

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PMC9878278

These IFNs induce several interferon-stimulated genes (ISGs) including MxA, IFIT1, and PRRs like RIG-I and TLR3 that collectively generate an antiviral state in neighboring uninfected cells and block viral replication in infected cells (Schoggins and Rice, 2011).

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PMC10589262

Quantification of immunofluorescence intensity further demonstrated that GRB2 and P85 colocalize with MT-KIT and GM130 at the Golgi complex (Supplementary Fig. S7).

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PMC10317042

Consistent with a previous study, we found that HDACi treatment decreases the expression of EWSR1::ATF1 in CCS cells, and we focused on elucidating the underlying suppression mechanism, which would facilitate the development of fusion gene–targeted therapy.

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PMC6133382

Single-stranded DNA oligonucleotides and their complement strands were synthesized (Eurofins Genomics, Louisville, KY, US) with extra bases on the 3′ ends for ligation into a GeneArt CRISPR nuclease vector (Thermo Fisher, GeneArt, Waltham, MA, US).

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PMC11252553

treated with Taurine (100 µg.

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PMC9341513

The FISH and simulation data generated in this study have been submitted to the Edinburgh DataShare repository (https://datashare.ed.ac.uk/handle/10283/4433).

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PMC9429973

NTRK3 expression was also strongly upregulated, suggesting a possible rationale for specific inhibitors.

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PMC5854676

The values for the slopes and y-intercepts were calculated using the least squares method.

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PMC9424261

As shown in Fig. 2A, compared with the control group, after CA treatment, we screened out three co-upregulated genes, namely HERPUD1, 3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1), growth differentiation factor 15 (GDF15) through transcriptome sequencing technology and tandem mass tags (TMT).

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PMC11731161

The data are expressed as mean ± SD. *

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PMC11515150

Moreover, both VHHs with 6×His tag or Fc tag competed with each other for binding to Jurkat cells by flow cytometry (Fig. 1e).

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PMC9429973

As genetic alterations in RPs drive anemia in Diamond-Blackfan anemia and myelodysplastic syndromes with chromosome 5q deletions, we evaluated eIF5A hypusination in different models of these bone marrow failure syndromes.

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PMC9429973

A connection between PPP inhibition and changed immune profile by modulation of the Stat1-Irg1-itaconate axis was identified and validated.

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PMC11748335

For instance, H3K9me3 is often associated with heterochromatin and is typically found along the nuclear periphery .

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PMC10253553

The decrease in RICTOR was associated with a statistically significant reduction in total NDRG1 protein (by ~50%) and phosphorylated NDRG1 (on Thr346) (between ~30 and 50%, for Ri #1 and Ri #2, respectively) relative to cells transfected with NT siRNA (Figure 2B).

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PMC11365427

This indicates that ATF3 expression directly activates DR5 transcription.

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PMC11474209

Excessive phosphorylation of p53 may trigger apoptosis by disrupting mitochondria, phosphorylating mitogen-activated protein kinases MAPKs to modify the cytoskeleton, and phosphorylating CaMKII to produce ROS species.

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PMC9024365

Cells were cultured at 37C with 5% CO2.

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PMC11792766

This includes both conventional cytotoxicity and cell viability assays and regulatory mutagenicity and genotoxicity assays.

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PMC11321678

However, the binding motif of NEUROD2 is only active in C2‐C5.

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PMC11078693

Increase the g-force of centrifugation staying below 1000 g when spinning the cells down to attach them to the cover glass.

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PMC10380508

Finally, protein detection was performed by incubating the membrane in freshly prepared SuperSignal West Pico Chemiluminescent Substrate.

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PMC9429973

Methods: Using flow cytometry, we sub-classified HSCs by combining “classic” HSC markers (CD150CD48LSK) with EMCN into EMCN HSCs and EMCN HSCs.

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PMC11634027

Cross-vein spacing was calculated by tracing the length of vein L4 between cross-veins, divided by the length of vein L3.

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PMC9436459

All ketalized MDAAs were reported as cis–trans configuration based on the coupling constants of H-4" with H-3" and H-5" (small J3"/4" and large J4"/5").

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PMC11423992

Collectively, these findings provided compelling evidence that TFAB002s as a novel class of tumor-targeted bispecific antibodies had promising antitumor efficacy and acceptable safety.

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PMC11604015

Another category of CAR-T cells includes autologous and allogeneic CAR-T cells.

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PMC10890055

The prepared samples were transferred to MEM or DMEM/Ham’s F-12 cultivation medium with 5% fetal bovine serum (FBS) and agitated (130 RPM) at 37 °C in closed vessels for 24 h. The surface-to-volume ratio was 87.5 mm·mL for all samples.

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PMC11763126

These results collectively suggest that CBDP1 inhibits ccRCC proliferation and metastasis by downregulating TRPM3 expression.

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PMC6889484

These substitutions were previously shown to have a minimal effect on virus replication.

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PMC11285179

Cluster 14, which was CSPG4 and ACTA2, was recognized as pericytes.

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PMC9545714

In this situation, the ultrastructure of the intercellular spaces of the stratum is altered, and the TEWL is markedly elevated.

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PMC11424574

Our results show that treatment with recombinant uPA (Rh-uPA) protein increased osteosarcoma cell migration (HOS cells, 298.5% increase; 143B cells, 234.2% increase) and cell invasive ability (HOS cells, 220.2% increase; 143B cells, 204.1% increase), compared with shLuc-OS cells (Figure 4).

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PMC9429973

Hence, cells have developed a variety of mechanisms to protect genome integrity and repair damaged DNA, collectively termed the DNA damage response (DDR).

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PMC9429973

100% ORR and 100% MRD negative rate, along with favorable safety evidenced support OriCAR-017 could be a competitive therapy for pts with R/RMM.

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PMC11394730

In a comparative study of ten polyphenols, including caffeic acid (CA), gallic acid (GA), catechin (C), epicatechin (EC), and their derivatives, EGCG exhibited a solid ability to induce apoptosis and cause G1 phase cell cycle arrest in cancer cells .

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PMC11723947

a, c Representative dot-plots showing the frequency of syngeneic (H-2K) and semi-allogeneic (H-2K) cells in the blood 21 days after engraftment.

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PMC11216402

We discovered a similar pattern of enrichment comparing TCGA-STAD and normal tissues with the cell lines (Fig. 2D, which is gene set enrichment analysis on PC2 of Fig. 2B).

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PMC8068766

Fifteen DEGs with high betweenness centrality values were identified by the PCST analysis for the between cell line comparison results, and eleven of these genes were Steiner nodes which were not differentially expressed but were determined to be on key positions on pathways that might have effects on the expression of...

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PMC9429973

Although prior studies have described an exhausted and pro-tumor T cell state, there may be potential to stimulate anti-CLL cytolytic T cell activity with novel therapy.

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PMC11740907

A comparison was made between the findings and the standard that had been set for cisplatin effectiveness.

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PMC11243198

Based on the calculated chemical properties (Table 2), BAS 07019774 (pyridin-4-ylmethyl-(4-pyrrolidin-1-yl-phenyl)-amine) meets the criteria of Lipinski’s rule of five (mol.

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PMC9429973

The cell concentration in the frozen suspension ranged between 69х10/ml and 665х10/ml (median 310,25х10/ml).

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PMC11770130

In the previous study, we performed an AAV injection-based experiment to validate the anti-thermogenic effects of NTS in BATs.

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PMC9429973

Aims: We aimed to formally investigate safety and efficacy of nivolumab and RT in r/r HL failing anti-PD1 treatment in a proof-of-concept study.

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PMC9812014

In the in vivo studies, HHT was efficient at suppressing PEDV viral production in piglets and hens at doses of 0.05 mg/kg and 0.2 mg/kg, respectively.

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PMC11401358

Statistical analysis of ROS levels in b. ****P < 0.0001, NS, no significance, t-test, data represent the mean ± standard deviation (SD).

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PMC11635519

A P value of less than 0.05 was considered to be statistically significant.

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PMC7840816

A value of p < 0.05 was considered to indicate a statistically significant result.

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PMC11672142

The n → π* absorbance at 385 nm (ε = 16,500 M cm based on ligand concentration) increases due to Fe(III) coordination (ε = 21,600 M cm based on ligand concentration).

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PMC11401358

NIH 3T3 cells (5 × 10) were seeded overnight on pretreated 6-well plates.

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PMC11745823

The results indicate that RIT1 suppression diminishes cellular proliferation in vivo.

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PMC11402217

In contrast, mice treated with MTX demonstrated an appreciable increase in bone mass compared to the model group.

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PMC11740907

An emptied aluminum pan served as a reference.

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PMC9429973

Results: In the survey part, all 64 participating physicians opted not to perform a repeat biopsy in at least one clinical case scenario.

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PMC10604092

The SLC-transplanted rats had >2-fold higher serum levels of fibroblast growth factor 21 (FGF21), insulin-like growth factor-binding protein 3, IL-1β, IL-10, neutrophil gelatinase-associated lipocalin (NGAL), plasminogen activator inhibitor type 1 (PAI-1), tumor necrosis factor alpha (TNF-α), and vascular endothelial g...

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