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OTAR3088
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BioData-CellLine_annotated

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PMC11424574
The expression of activated ERK1/2 in shLuc and shMTA2 cells by western blot assay. (
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PMC11725127
Utilizing the Gene Expression Omnibus (GSE13591) database, we observed notably higher USP2 mRNA levels in bone marrow samples from MM patients, compared with healthy donors (Fig. 6G).
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PMC8916024
C1–C5: sediment samples.
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PMC9429973
F. Nadeu, S. Shuai, G. Clot, L. K. Hilton, A. Diaz-Navarro, S. Martín, R. Royo, T. Baumann, M. Kulis, I. López-Oreja, M. Cossio, J. Lu, V. Ljungström, E. Young, K. Plevova, B. A. Knisbacher, Z. Lin, C. K. Hahn, P. Bousquets, M. Alcoceba, M. González, E. Colado, M. Aymerich, M. J. Terol, A. Rivas-Delgado, A. Enjuanes, S...
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PMC11806182
These results underscore the importance of miRNA regulation in processes like cell division, extracellular matrix organization, and TGF-β signaling, all critical in cancer progression .
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PMC10728535
It seems that several regulatory genes and signaling pathways are associated with the emergence of the chemo‐resistant phenotype.
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PMC9454852
A characteristic trait of MPM cells is the constitutive deregulation of the ER homeostasis and high UPR signaling, with respect to mesothelial cells, which confer resistance to standard therapy.
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PMC10932641
ns, no statistical significance; ****, P<0.0001.
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PMC11623887
It paves the way for further research to elucidate the precise mechanisms by which GATA1 interacts with the B19V genome and its potential role in the pathogenesis of B19V-related erythroid and hematological diseases.
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PMC9429973
The likelihood of dying from multi-organ dysfunction or HLH was 26 times higher in OHI+ vs. OHI- patients (OR 26.2; CI 4.1-286.7).
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PMC11770746
Sharp and quick leg withdrawal or immediate jumping in response to a touch with the hairs was considered as a withdrawal response.
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PMC7582629
Both infrared (IR) and RS have been used in the analyses of biological samples and for the structural characterization of cellular components .
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PMC7987994
Error bars stand for the standard error deviation of six measurements.
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PMC11063646
The viscosity of the formulated gels ranged from 2190 ± 101 cPs to 8020 ± 125 Poise (Table 7), and an increase in xanthan gum concentration resulted in increased viscosity (Pan et al., 2021).
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PMC8903741
This resulted in a finding of 10-fold higher sensitivity of the antibody produced in this study than the commercial antibody (Fig. 4D).
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PMC5854676
After 10 min of drug delivery. (
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PMC11707577
Phages present in the solution were precipitated by lowering pH to 4.2, corresponding to M13 isoelectric point (IEP), and centrifuging at 12 000 g for 10 min.
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PMC11612508
Controlled drug delivery systems have been intensively researched for cancer treatment to increase precision targeting and therapeutic efficacy.
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PMC11036064
Accumulating evidence has highlighted the significance of microRNA (miR) dysregulation in tumor development and progression.
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PMC11352877
Establishing a solid blood supply allows the pathological tissue to persist and grow.
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PMC11543853
g–j Ruptured endosomes release rhinovirus 2 into the cytoplasm.
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PMC11449273
H1299- p53 and H1299-PG-p53 were run on the same gel separated by a lane. *
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PMC11740508
p < 0.0001; ***, p < 0.001; **, p < 0.01; *, p < 0.1; ns, not significant.
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PMC9429973
Safety profiles for C+R and P+R were mostly unchanged from the initial disclosure, and the most common treatment-related AEs for pts receiving C+R were hyperglycemia (69.4%), hypertension (49.5%), and diarrhea (33.9%).
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PMC8584666
In conclusion, GPI-80 level in tumor cells is associated with several events such as survival in non-adherent conditions, slow cell proliferation, or protumorigenic inflammation.
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PMC11694346
However, it is essential to note that further investigation is required to assess its viability for time-lapse imaging, particularly in determining whether the dye remains stable under continuous excitation light.
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PMC11525028
We identified NAT10 as a candidate therapeutic target for osteosarcoma and revealed that NAT10 plays a critical role in osteosarcoma growth and metastasis.
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PMC10154881
This finding is a basic mechanism, implying that rMV‐SLAMblind cancer therapy has the potential to prevent or eradicate metastatic cancer.
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PMC11301242
We compiled a manual list of DNA mismatch repair (MMR) and Non-Homologous End Joining (NHEJ) genes, referencing the Human Gene Sets from GSEA-MSigDB .
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PMC11767793
This extra absorbance was not negligible; however, the final MTS optical density reading could be corrected by performing a control absorbance measurement prior to introducing the MTS reagent and subtracting the interfering absorbance from the recorded value.
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PMC11661040
Fig. 2Silence CGREF1 blockade of osteosarcoma cells of the cell cycle, inhibit cell proliferation. (
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PMC9966931
Cinnamomun verum and Thyme vulgaris EOs and their organic extracts exert numerous biological activities because of their major compounds, particularly thymol, carvacrol, eugenol, and benzoic and cinnamic acid.
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PMC10777969
There is no proof that the anhydrosugar moiety has any effect on biological properties.
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PMC10253553
The levels of phospho-NDRG1 (Thr346) dropped below 90% when Torin 2 was applied at 50, 250, and 1000 nM concentrations, which also stimulated the accumulation of cleaved-PARP (Figure 3B and Figure 6B) in 786-0 cells.
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PMC9429973
Methods: In order to execute this, we carried out a retrospective analysis of all FL patients that received a first line treatment (ICT) at our institution and underwent an iPET/iCT between 2008 and 2021.
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PMC11467964
Under the guidance of the manufacturer's protocol, total cellular RNA was extracted using RNA Express Total RNA Kit (New Cell & Molecular Biotech, M5100).
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PMC10698968
A Wound healing assay: representative images of cells closing the scratch (top); Graph reporting the area of the plate not covered by cells (wound area) at the different timepoints (bottom); B Invasive potential assay through 24-well transwell filter coated with collagen.
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PMC5311252
Further, our analysis shows that in sporadic cases, oncomotif-miRNA expression from other genomic loci becomes dominant.
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PMC9429973
The response rate after 6 cycles of ZRCHOP regimen was obviously higher than that of the previous report after R-CHOP regimen for DE-DLBCL (85.7%VS 70%).
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PMC11670407
The collected lysates were heat denatured for subsequent IP experiments.
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PMC9429973
Cumulative rates per treatment year are shown in the Table.
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PMC11206502
Absorbance was measured at 570 and 620 nm using a Multiscan FC plate reader (Thermo Ficher Scientific, Vantaa, Finland).
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PMC11449273
Plates were incubated at 37°C, 5% CO2 for two weeks and supplemented with 0.3 mL CMEM every three days.
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PMC11673902
The diameter of the constriction channel is slightly smaller than the diameter of the test cell, and as the cell passes through the channel, it is deformed by pressure from the channel wall.
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PMC11545737
It has entered different clinical trials for various conditions, such as cocaine abuse (ClinicalTrial.gov [https://clinicaltrials.gov/, accessed on 14 September 2024] ID: NCT00580827, NCT00218608, NCT00395850, NCT00000278, NCT00094289, NCT00913484, NCT00729300, NCT00142844 and NCT00149630), HIV infection (ClinicalTrial...
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PMC11098378
Using this approach, we identified 24 moth proteins that were enriched at least five-fold in IpaH4 reactions compared to UBAIT reactions conducted with IpaH2.5 constructs, which served as our control (Fig 5D and S3 Table).
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PMC11026382
Transformants for each library were then grown as a mixed population in selective media in a turbidostat to ensure maintenance of exponential growth and constancy of media conditions.
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PMC9429973
We have previously shown that in this setting GVL is not associated with GVHD in AML but there are currently no data on this association in ALL.
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PMC10587429
These results are consistent with the previous findings that tumor associated macrophages are predominant while few cytotoxic T or NK cells are found in ES patient tumors (20).
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PMC11585994
Additionally, the nanoparticles similarly induced apoptosis while inhibiting the cell viability of primary T-ALL cells (Figure 3C and D).
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PMC10907726
Evidently, some progress has been made in the study of DATS in the treatment of bone tumors.
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PMC9596868
p ≤ 0.05; **p ≤ 0.01).
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PMC11683240
Additionally, well-designed clinical trials are needed to evaluate the efficacy, optimal dosing, and long-term outcomes of α1AT therapy in pertussis patients.
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PMC11730320
Appropriate distance threshold to determine clonal relationships was performed on ShazaM, while clonal assignment was performed with scoper (v.1.3.0).
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PMC10965315
According to the current in vitro study, harmaline has dose‐dependent proliferative inhibition effect on A2780 cells.
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PMC9031474
Additionally, dialdehyde drimanes activate the TRPA1 ion channel.
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PMC11317131
We used IntePACE to perform over 200 rounds of mutagenesis in just a few days, a process that would take years using traditional directed evolution methods (35).
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PMC10808409
The solubility of FA in water was 40 μg/ml, while in O1 and in O2 was 780 μg/ml and 858 μg/ml, respectively.
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PMC4270159
Preparation of cell lysate: a. Note: from here on, the replicating lab will use their in-house Western blot protocol, as recommended by the original authors.
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PMC9545714
A secondary but extraordinary finding of the present study was the upregulation of a series of genes coding for olfactory receptors.
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PMC9429973
M. Vlachová, M. Štork, S. Ševčíková, T. Jelínek, J. Minařík, J. Radocha, P. Krhovská, L. Pospíšilová, I. Špička, J. Straub, P. Pavlíček, A. Jungová, V. Sandecká, V. Maisnar, R. Hájek, L. Pour Babak Myeloma Group, Department of Pathophysiology, Faculty of Medicine, Masaryk University; Clinic of Internal Medicine, Hemato...
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PMC10114490
diHLC-T data is extracted from this study.
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PMC7022782
For TEM observations, the procedure reported in Obinu et al. was followed .
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PMC11594074
In contrast, compound 2 did not exert significant cytotoxicity in any of the selected cell lines.
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PMC11679326
Branching of the biantennary glycan occurs with the help of the enzymes N-acetylglucosaminyltransferase IV (MGAT4) and N-acetylglucosaminyltransferase V (MGAT5).
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PMC9429973
The estimated post–allo-SCT cumulative incidence for TRM at 6 months was 0.09 (95% CI, 0.03-0.17) and for relapse at 26 months was 0.27 (95% CI, 0.16-0.38).
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PMC11656657
Supernatant from tumor cultures was collected at 72 h, to measure cytokines release.
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PMC11381192
However, the impact of cell stress‐related genes on MM prognosis and treatment remains inadequately supported by the available evidence.
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PMC11659921
To identify the most relevant prognostic genes associated with angiogenesis and stemness in OV, we applied a narrow filter to a set of 12 selected genes using the LASSO algorithm.
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PMC11796104
Real-time quantitative PCR was conducted using the MicroRNAs Quantitative PCR Kit (Novozymes, Nanjing, China) and the ABI 7500 Real-Time PCR System (Applied Biosystems, USA).
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PMC10940855
For example, BM osteoblasts endow quiescent multiple myeloma cells with colony-forming potential (8, 9) and BM fibroblasts promote multiple myeloma cell growth and survival in the BM (9).
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PMC9429973
Aims: To present our experience in the management of PCL.
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PMC10391797
Therefore, it is likely that a combination of CAR-T cell therapy with agents involved in T cell activation could be a novel potency to treat AML by activating T cells.
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PMC9429973
But the mechanism(s) underlying these observations are not well described.
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PMC10222971
Usually, most women are diagnosed with advanced stage cancer with a poor prognosis (with a 5-year survival rate of only 17% for a patient at an advanced stage), which is partly driven by delay in diagnosis and unequal access to quality care.
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PMC10654497
Calibration curve of the nomogram.
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PMC11740399
The uptake mechanism of these hybrid liposomes in bladder cancer cells was investigated using inhibitors of caveolin-1 (filipin) alongside Dil-labeled 3025@ML via flow cytometry.
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PMC11470999
Our results showed that PF had superior inhibitory activity on melanoma growth compared to TMZ in both B16 and A375 cells (Figure 1B), with similar results observed in colony formation assays (Figures 1C and S1B).
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PMC2777936
The established role of Wnt signalling in development and its misregulation in cancer and other diseases highlights the need for a more complete understanding of how this pathway works.
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PMC11394112
We found that our models show consistent tumor burden with unformal disease progression and organ-specific infiltration.
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PMC9739791
To study the cell death mode induced by the prodrug 17, confocal images of MCF-7 cells incubated with BODI-Pt 17 and irradiated for 30 min with green light were obtained.
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PMC11594806
In breast cancer research, Dr. Loi’s team analyzed gene expression data from 6000 breast cancer (BC) patients, identifying an association between CD73 expression and poor prognosis in triple-negative breast cancer (TNBC) patients.
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PMC7917457
The substrate in the Quanti-BLUE (InvivoGen) system turns purple/blue in the presence of SEAP.
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PMC10376064
In summary, we could show for the first time that DMF seems to functionally inhibit ABCC1-mediated transport of the ABCC1 substrates daunorubicin and rhodamine 123.
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PMC11637276
For invasion analysis, spheroids were thresholded, and the area of the selected threshold was quantified in Fiji/Image J. The invasion rate was defined as the ratio between the invasion area and the total area.
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PMC11767582
Thus, compound 3n turned out to be the most active one against the lung cancer A-549 cell line (IC50 = 3 nM), albeit less selective for tumor cells than 3r, which was the second most active for the lung cancer cell line (IC50 = 9 nM) and very selective for tumor cells.
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PMC9429973
Infections were classified as microbiologically defined, clinically defined and fever of unknown focus according to definitions published by the International Immunocompromised Host Society.
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PMC9429973
The frequency distribution of mutations G1691A in the F5 gene (Leiden mutation), G20210A and T165M in the F2 gene, C677T and A1298C in the MTHFR gene, and (-675)4G/5G in the PAI-1 gene in groups #1 and #2 is presented in Table 1.
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PMC9503669
In this study, Nef induced remarkably subtle changes in deuterium uptake by Hck, with the most significant occurring in the N-lobe of the kinase domain adjacent to the docking site for Nef on the SH3 domain.
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PMC10547921
Currently, only one ADC with PDB as the payload is in clinical use.
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PMC9429973
To evaluate the role of mtDNAc during drug-induced apoptosis, we treated primary AML blasts (n=67) with cytarabine (AraC, 100 nM) for 48h.
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PMC11731161
The ubiquitination of XPO1 was assessed utilizing the anti-ubiquitin antibody.
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PMC9581083
It is an important medicinal plant that is commonly used in Chinese herbalism.
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PMC11377827
Here, using a bespoke DUBs sgRNA library we conduct CRISPR/Cas9 mutagenesis screens to determine how DUBs are involved in HIF signalling.
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PMC11705630
Wound areas were calculated using ImageJ. For western blot assay, cells and tissues were lysed by radioimmunoprecipitation assay buffer (RIPA buffer) (EBA-1149, Elpis Biotech, Daejeon, Republic of Korea) containing protease inhibitor cocktail and phenylmethylsulfonyl fluoride (PMSF).
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PMC9429973
At a median observation time of 8 months (range <1–11), the overall response rate (ORR) was 67% (18 pts; complete response [CR]:19.0% [5 pts], VGPR:37% [10 pts], partial response:11% [3 pts]).
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PMC10723784
The apoptotic event may involve loss of mitochondrial membrane potential, Annexin V, caspase 3/7, ROS activities, and cell cycle arrest.
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PMC11628309
Additionally, the synthesis of enzymes responsible for the degradation of these neurotransmitters allows for a multifaceted evaluation of the disruption of normal dynamics in a neuronal environment, thereby providing a direct focus on the pathology of PD.
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PMC11528603
This abnormal morphology bears similar trait with the mitotic catastrophe wherein the cell replication is halted.
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PMC8557138
This indicates requirement of developing vascular models specific to tumor tissues to understand intricate processes of tumor angiogenesis and clinical applicability.
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