OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC9429973	Summary/Conclusion: Subcutaneous epcoritamab had a manageable safety profile when combined with R-DHAX/C in pts with R/R DLBCL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "Subcutaneous", "e...
PMC9429973	Image: Summary/Conclusion: Subcutaneous azacitidine and romidepsin administered in a ‘real-world’ situation is highly effective in patients with relapsed PTCL with tolerable toxicity, and can be used to successfully bridge patients to stem cell transplant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11640555	In this study, when U-87 cells were treated with CX-4945, the NF-κB pathway was reduced, and CK2 inhibition resulted in a decrease of pro-inflammatory mediators involved in the signaling of the transcription factor, leading to the lower expression of downstream ILs such as IL-18 and mediators like iNOS and COX2.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Comparison between PPCs and cfDNA showed that 20 out of 23 (87%) mutations identified in the PPCs were observed in the cfDNA, whereas 32 out of 35 (91%) mutations were observed in BM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11194678	For imaging, proteins were injected into a homemade flow chamber comprised of a glass slide sandwiched by a coverslip with one layer of double-sided tape as a spacer for DIC (OLYMPUS IX73) or fluorescent imaging (Leica TCS SP8) (Shan et al., 2018).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11643361	In comparison, cisplatin induced apoptosis in 82.1% of cells and necrosis in 15.4%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "comparison", ",", "cisplatin", "induced", "apopt...
PMC11515150	The resistance of PB-derived NK cells to transduction is a virtual hurdle in the successful modification of CAR-NK cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "resistance", "of", "PB-der...
PMC9429973	CD7 positivity adversely affected both the OS and EFS at 5 years (26% vs 43%, p=0.05 and 27% vs 49% p=0.04 respectively), with an inferior CR rate to induction (43% vs 65% p=0.1) and a higher relapse rate (37% vs 21%, p=0.2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10873328	TGFBI promoted chemoresistance through inhibiting apoptosis and facilitating DNA damage repair via activating PI3K/Akt signaling pathway. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TGFBI", "promoted", "chemoresistance", "through", ...
PMC10529414	HEK293T cells (Life Technologies-USA) were cultured in 60 mm plates in DMEM supplemented with 10% FBS and 5% antibiotic solution (ampicillin and streptomycin).	[ { "tags": [ "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11474209	Promote cancer metastasis33Human hepatoma-derived cell line (Huh7)0.5–100 µMp53, PP2Ac, ATF−4, BiP, NF-κB, IFN-α, ATF−4, CHOP, CREBPP2A, IRE1, PERK,Antiviral defense, restriction of cell proliferation, and apoptosis encourage tumor growthInflammation, tumor-causing toxic effect on liver34HL77020.001–10 MK8/18 and vimen...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11502962	High infiltration of macrophages predicts poor prognosis in multiple types of tumors and is considered the reason of suppressed antitumor inflammatory setting (26–28).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11343332	Human breast cancer cells were treated with pycnogenol (80 µg/ml) for 24 h, along with the control group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Human", "breast", ...
PMC10213179	Aptamer treatment in an in vivo orthotopic mouse model: animal models for tumor growth or metastatic detection were performed as described by López-Alemany and Tirado.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11612794	These findings deepen our understanding of kinetochore assembly in cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "deepen", "our", "understanding", "of", "kinetochore", "assembly", "in", "ce...
PMC10719213	This technical noise limits our sensitivity to detect new mutations, especially in the ex vivo lymphocytes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "technical", "noise", "limits", "our", ...
PMC11727145	The exudates from the early and late collections were used purely at 100% to screen any negative effects on cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "exudates", ...
PMC9532503	Sample preparation and glycan labeling was done using the glycan labeling kit (Ludger, UK).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sample", "preparation", "and", "glycan", "labelin...
PMC9429973	In patients intended to undergo salvage therapy followed by ASCT (n=18, n=13 transplanted) or AlloSCT (n=5, all transplanted), the 2-year PFS rate and 5-year OS rate were 80% (95% CI 52-100) and 60% (95% CI 41-88), and 80% (95% CI 52-100) and 61% (95% CI 42-88), respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Most deaths were caused by the original disease (75.4%) with concomitant infection (5.9%) or with multiorgan failure (4.3%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6742971	We conclude that the anti-tumor effect of adoptively transferred T cells is not hampered by the co-presence of T cells with lower avidity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", ...
PMC3931643	We next tested whether maintenance of the eIF4F complex in VAL cells treated with MLN0128 preserved cap dependent translation and overall protein synthesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC5925824	Results are represented as a geometric mean of engraftment + SEM with n = 9 mice on day 18 and day 34, and n = 5 mice on day 46.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Similarly, patients with egular hospital visits had a median overall survival (OS) of 107.4months, which was also better than that of patients with irregular hospital visits (37.1 months, p < 0.001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10529414	In summary, our results show that the overexpression of RUNX2 in lung cancer is related to its occupancy at different genomic regions, principally at intergenic regions (61%), introns (29%), and promoters-transcription start sites (TSSs) (5%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11021472	Expression levels of circZDHHC11 in WT ST486 and the monoclonal NTCR1CR2 control and miR-150BSdel mutant cell lines were analyzed by RT-qPCR. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Expressio...
PMC11499955	These results showed that our approach can be used to profile tumor biopsies by detecting several biomarkers in one single process.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", ...
PMC11283030	Neg: negative, Pos: positive, Meta: metastasis. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Neg", ":", "negative", ",", "Pos", ":", "positive", ",", "Meta", ":", ...
PMC11747885	In this assay, the 5′ open loop sequence was labelled with P-phosphate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "assay", ",", "the", "5′", "open", "loop", "sequence", ...
PMC11746948	e GPX4 palmitoylation in A375 cells infected with lentiviruses encoding control shRNA or ZDHHC20 shRNA, and incubated with 50 μM Alk14 for 12 h, determined using the click chemistry assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11743316	Fig. 1 Mitochondrial abnormalities in cancer show that various elements of cancer cells can be altered.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "1", "Mitochondrial", "abnormalities", "in", "c...
PMC11772585	E EdU staining assay was used to assess cell proliferation (n = 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "E", "EdU", "staining", "assay", "was", "used", "to", ...
PMC11541241	The management of fungal diseases is mainly dependent on the application of fungicides, which are not suitable for sustainable agriculture, human health, and environmental safety.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11337594	n = 3) (E, F) A375 cells were exposed to lower doses of TER (0.1, 0.3 and 0.5 µg/ml) for 48 h. The cells were labeled with PI and detected by flow cytometry Although we observed cleavage of CASP3, a key protein involved in apoptosis, following TER treatment, it is important to note that knockout of CASP3 did not allevi...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10006224	Resolution is 100 kb/bin in I and 25 kb/bin in II.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Resolution", "is", "100", "kb/bin", "in", "I", "and", "25", "kb/bin", "in", "II...
PMC9920575	The fruit of Sechium edule (Jacq.)	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "fruit", "of", "Sechium", "edule", "(", "Jacq", ".", ")" ] } ]
PMC10698968	TEM images in Fig. 4C show, for the first time, the ultrastructural details of a primary MFS cell culture, enlightening the irregular and hypertrophic shape of MF-R 3 nucleoli.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9895440	All images are provided in the Source Data file.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "images", "are", "provided", "in", "the", "Source", "Data", "file", "." ] } ]
PMC11756514	The diluted mixture was dialyzed twice against 2 L loading buffer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "diluted", "mixture", "was", "dialyzed", "twice", "against", "2", "L", "loading...
PMC10809689	The α-KG reduction in the PG72 group could be due to the decrease in the amount of glutamate in the treated groups for the production of non-essential amino acids or purine and pyrimidine nucleotides for DNA synthesis in the cells, as well as the activation of the cell and the Krebs cycle .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11798926	All cell lines were grown in a humidified incubator at 37°C and 5% CO2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "cell", "lines", "were", "grown", "in...
PMC11637276	d, e) Collagen I uptake index and α2 integrin internal pool were calculated with ImageJ. Values represented are normalised mean + SD from N = 3 independent experiments; ****p < 0.0001; Kruskal–Wallis test. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11748335	Afterward, we utilized computeMatrix to determine the replication timing of each merged common PMDs with Repli-Seq data of five normal cell lines (HUVEC, IMR90, NHEK, BJ_1 and BJ_2) from UCSC database and the average signals of the quantile normalization results were obtained.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", ...
PMC9429973	Finally, we provided the first evidence that Hh inhibitors represent a promising new therapeutic target.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "we", "provided", "the", "first", ...
PMC9429973	Overall, 135 (77.5%) patients had been previously treated with rituximab, 33 (16.5%) of them within 12 months before vaccination.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11752740	Fa (Fraction affected)/Fu (Fraction unaffected) = (D/Dm) m, where D represents the dose required to achieve Fa, Dm is the median-effect dose, and m is the slope Combination Index plot illustrating the effects of pistachio hull extract (E) and carfilzomib (CFZ) on SK-BR3 and MCF10A cell lines at 24- and 48-hours post-tr...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Image: Summary/Conclusion: This finding underlies the central role of JAK2V617F mutation in the pathogenesis of unusual type VTE in MPN, which occurs as sole molecular alteration in more than 90% of cases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11599565	The MET-driven conversion of cells which originally belong to the same embryonal layer, regardless of the type, has been previously reported.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11541409	This reference supports the longer time of imatinib treatment is effective and safe.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "reference", "supports", "the", "longer", "time", "of", "imatinib", ...
PMC11723947	e–g Percentage of HLA-B7 WT and HP1γ KO human Tconv producing IFN-γ (e), GM-CSF (f) or Granzyme B (g).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11544122	No. 51-01-08-22 and 51-01-19-09) were from Integrated DNA Technologies (Newark, NJ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11640555	The results of the present study demonstrated that CX-4945 displayed significant inhibition of proliferation on the U-87 cell line, indicating that U-87 cells might be sensitive to CX-4945 in terms of downregulation of CK2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "...
PMC10391797	As expected, cells involved in antitumor or anti-inflammation processes, including activated CD4 memory T cells, follicular helper T cells, and activated NK cells, were significantly decreased in patients with AML (figure 1E), reflecting immune dysfunction in AML.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10975211	This approach combines different therapeutic agents, enhancing their individual properties and enabling targeted drug delivery .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "approach", "combines", "different", "therapeutic", ...
PMC9429973	At the time of MDS dx, 31 (43%) pts had t-MDS: 97%, 58% and 29% had a history of chemotherapy, radiation, and prior stem cell transplant (SCT), respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11401350	Nevertheless, the anti-CD4CAR CD8 T cells will target all CD4 T cells, malignant or healthy, which might lead to some immunosuppression in the patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2944824	Rabbit antibodies against human hairless, mouse bcl2, (both Abcam) and mouse cytochrome C (Invitrogen) were used at 1∶100 dilution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10808409	Total pluronics: 200 mg Pluronic P123:90% Drug amount: 8.58 mg *Prediction error = Predicted value – Observed value/Predicted value × 100.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11271800	Imatinib (STI571) was first used clinically in 2002 and achieved significant efficacy in the treatment of a patient with metastatic GI mesenchymal stromal tumor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11055323	The green boxes indicate the newly formed long-range interaction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "green", "boxes", "indicate", "the", "newly", "formed", "long-range", "interaction", "." ] } ]
PMC11748335	Following the LOLA R package manual, we added custom target regions and conducted LOLA analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Following", "the", "LOLA", "R", "package", "manual", ...
PMC11731614	The predicted protein targets for let-7 and miR-23 were obtained by cross-referencing 3 separate databases: MirDB, TargetScan, and DIANA-microT. The protein targets predicted by all three programs were used for downstream analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Randomization: 2:1 to MMB 200 mg QD plus DAN placebo or DAN 600 mg QD plus MMB placebo for 24 wks, after which pts could receive open-label MMB.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11650848	A heatmap was generated comparing the two mQTLs discussed, along with three additional SNPs in close proximity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "heatmap", "was", "generated", "co...
PMC9848491	The AUCs of 1, 3, and 5-years survival were 0.625, 0.805, and 0.79, respectively ( Figure 8A ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC8164677	Drugs targeting such checkpoints, Chk1 being one of them, are the focus of multiple clinical trials.14 Decreased accumulation of platinum drugs is one of the mechanisms of the development of resistance to the drugs by the cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7039683	To test this prediction, we dissected palate shelves from mouse embryos at embryonic day (E)14.5 and manually removed epithelium, both basal and periderm layers together, after brief incubation in trypsin (Figure 5A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754436	In the pCMV NPEPPS group (pN), NPEPPS was overexpressed using the pCMV NPEPPS vector.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "pCMV", "NPEPPS", "group", "(",...
PMC11657744	Cep89 or Fbf1-depleted ciliated cells were treated with 10% fetal bovine serum to induce ciliary absorption.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cep89", "or", "Fbf1-depleted", "ciliated", "cells...
PMC10812665	The effect of normalization was checked by boxplots and distribution plots (not shown) and no outlier samples were identified.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "effect", "...
PMC10850553	Secondary antibodies used were as follows; Alexa Fluor 488-conjugated donkey anti-mouse IgG H&L antibody (#A21202, Thermo Fisher Scientific), Alexa Fluor 488-conjugated donkey anti-rabbit IgG H&L antibody (#A21206, Thermo Fisher Scientific), Alexa Fluor 594-conjugated donkey anti-mouse IgG H&L antibody (#A21203, Thermo...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10877303	6Two-dimensional (2D) view of the interactions between MERS-CoV 3CL and the top inhibitor (Nafamostat).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "6Two-dimensional", "(", "2D", ")", "view", "of", ...
PMC10380508	In the TCGA data analysis, we observed a correlation between the expression levels of PAX2 and PAX8 and the clinical outcomes of RCC patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC5874706	Aliquots of the cell suspension with the respective RBC number of 5 × 10 were added to the PBS solution (pH 7.2) containing increasing concentrations of the samples investigated in the study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11269933	Those residues with high RMSF values are labeled.(C) The time course of SASA values of the two systems.(D) The RDF values around K279 of PK.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9844987	The Random Forest model was implemented and trained in Scikit-learn (version 2.3.0) with 500 trees, a maximum depth of trees of 10, 50samples split per node, and 50samples to be at a leaf node.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11487720	In contrast, the formation of the WWOX/TRAF2 complex, plus p53, was strengthened at 37 °C required for apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contra...
PMC10996034	P<0.05 was considered to indicate a statistically significant difference.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P<0.05", "was", "considered", "to", "indicate", "a", "statistically", "significant", "difference", "." ...
PMC11705862	Our data are consistent with these findings, as they showed marked downregulation of IRIS-1 and 2 expressions in hippocampal neurons in AD and T2D cases, compared to controls.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11585565	To examine cellular localization, the mutant and WT plasmids were transfected into a HEK293 cell line, and immunofluorescent staining was performed at 24-hours post-transfection (Fig. 2a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11340319	A variety of demographics were collected.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "variety", "of", "demographics", "were", "collected", "." ] } ]
PMC11761919	Control groups included microcapsules with Fiber2-expressing E. faecalis, microcapsules with Fiber2-expressing E. faecalis and 0.01 g of inulin, and microcapsules without bacteria.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Chimeric antigen receptor T-cells (CAR-T) targeting CD19 are effective, and axicabtagene ciloleucel is currently approved by FDA for treatment of patients (pts) with relapsed FL, but toxicities like cytokine-release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) may limit its use.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11310713	Scale bars, 200 μm. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", ",", "200", "μm", ".", "(" ] } ]
PMC11297139	c Representative confocal images demonstrating the colocalization pattern of recombinant ARID1A proteins (green) and SMARCB1 (red).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "c", "Representative", "confo...
PMC8073654	The binding energy calculations of the 5-LO complex with 1, 2, and zileuton (anti-asthma agent) were −29.15, −26.83, and −29.40 kcal/mol, respectively, which supports the competition between the 1 and 2 substrate inhibitors, which was the same as zileuton .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11627133	Cells were incubated with 1000 nM aptamer (incubated for 30 min), washed once with ASB and stained with 500 nM SiR (15 min prior to imaging).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11759543	This research was supported in part by the 10.13039/100020595National Science and Technology Council, Taiwan, R.O.C. (grant number NSTC112–2320-B-415-002) and SKBIO Technology Corp. (grant number Shen-1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10419319	Collectively, these results indicate that isoalantolactone effectively regulates cisplatin-resistant cells, particularly A2780 and SNU-8 OC cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Collectively", ",", "these", ...
PMC11650848	D prime is an indicator of allelic segregation of SNPs and ranges from 0 to 1 (0 indicates no linkage between SNP alleles, 1 represents a tight linkage of SNP alleles).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7348793	The gaps were closed by PCR-amplifying respective regions using sequencing primers and sequencing the resulting shorter fragments with additional primers (Supplementary Table S1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9964635	It is composed of 100 μg/mL streptomycin, 100 units/mL penicillin, and 10% FBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "composed", "of", "100", "μg/mL", "st...
PMC11377827	HIF-1α ChIP-PCR for HREs of CA9, PHD3 and VEGF in control, HIF1β or USP43 depleted HeLa cells treated with 21 or 1% oxygen for 6 h. n = 4 biologically independent samples, mean ± sd.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11604830	The resulting spectra clearly demonstrated the presence of the nanoparticles only in the right PLN corresponding to the mouse side where the tumor lesion was located (Figure 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Enrichment of double positive cells by MACS and injection into NSG mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Enrichment", "of", "double", "positive", "cells", "by", "MACS", "and", "injectio...
PMC10747139	Recently, the combination of RAPTA-C and paclitaxel based on fructose-coated nanoparticles has been suggested as a dual drug delivery system for the treatment of metastatic cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11673128	Conversely, to assess the phagocytic activity in the resistant setting, we used the AS4 cell line, which is known to carry on-target and off-target resistance mechanisms against crizotinib and lorlatinib, respectively (Table S1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11790599	This dysregulated process, driven by accelerated macropinocytosis, contributes to abnormal cellular drinking and, ultimately, the rupture of cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", ...
PMC11782780	Our study provided experimental evidence to demonstrate that EBF3 knockdown considerably enhanced glycolysis in BC cells, promoting their stem-like phenotype, while the addition of 2-DG attenuated the promoting effect of EBF3 knockdown on glycolysis and cell stem-like phenotype of BC cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11489175	Although the preclinical efficacy of small-molecule USP7 inhibitors was demonstrated in vivo and the synergistic effect of combining USP7 inhibition with cancer immunotherapy appears promising, the field seems to be at its infancy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Summary/Conclusion: Subcutaneous epcoritamab had a manageable safety profile when combined with R-DHAX/C in pts with R/R DLBCL.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "Subcutaneous", "e...

PMC9429973

Image: Summary/Conclusion: Subcutaneous azacitidine and romidepsin administered in a ‘real-world’ situation is highly effective in patients with relapsed PTCL with tolerable toxicity, and can be used to successfully bridge patients to stem cell transplant.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11640555

In this study, when U-87 cells were treated with CX-4945, the NF-κB pathway was reduced, and CK2 inhibition resulted in a decrease of pro-inflammatory mediators involved in the signaling of the transcription factor, leading to the lower expression of downstream ILs such as IL-18 and mediators like iNOS and COX2.

[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Comparison between PPCs and cfDNA showed that 20 out of 23 (87%) mutations identified in the PPCs were observed in the cfDNA, whereas 32 out of 35 (91%) mutations were observed in BM.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11194678

For imaging, proteins were injected into a homemade flow chamber comprised of a glass slide sandwiched by a coverslip with one layer of double-sided tape as a spacer for DIC (OLYMPUS IX73) or fluorescent imaging (Leica TCS SP8) (Shan et al., 2018).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11643361

In comparison, cisplatin induced apoptosis in 82.1% of cells and necrosis in 15.4%.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "comparison", ",", "cisplatin", "induced", "apopt...

PMC11515150

The resistance of PB-derived NK cells to transduction is a virtual hurdle in the successful modification of CAR-NK cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "resistance", "of", "PB-der...

PMC9429973

CD7 positivity adversely affected both the OS and EFS at 5 years (26% vs 43%, p=0.05 and 27% vs 49% p=0.04 respectively), with an inferior CR rate to induction (43% vs 65% p=0.1) and a higher relapse rate (37% vs 21%, p=0.2).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10873328

TGFBI promoted chemoresistance through inhibiting apoptosis and facilitating DNA damage repair via activating PI3K/Akt signaling pathway. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TGFBI", "promoted", "chemoresistance", "through", ...

PMC10529414

HEK293T cells (Life Technologies-USA) were cultured in 60 mm plates in DMEM supplemented with 10% FBS and 5% antibiotic solution (ampicillin and streptomycin).

[ { "tags": [ "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...

PMC11474209

Promote cancer metastasis33Human hepatoma-derived cell line (Huh7)0.5–100 µMp53, PP2Ac, ATF−4, BiP, NF-κB, IFN-α, ATF−4, CHOP, CREBPP2A, IRE1, PERK,Antiviral defense, restriction of cell proliferation, and apoptosis encourage tumor growthInflammation, tumor-causing toxic effect on liver34HL77020.001–10 MK8/18 and vimen...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11502962

High infiltration of macrophages predicts poor prognosis in multiple types of tumors and is considered the reason of suppressed antitumor inflammatory setting (26–28).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11343332

Human breast cancer cells were treated with pycnogenol (80 µg/ml) for 24 h, along with the control group.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Human", "breast", ...

PMC10213179

Aptamer treatment in an in vivo orthotopic mouse model: animal models for tumor growth or metastatic detection were performed as described by López-Alemany and Tirado.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11612794

These findings deepen our understanding of kinetochore assembly in cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "deepen", "our", "understanding", "of", "kinetochore", "assembly", "in", "ce...

PMC10719213

This technical noise limits our sensitivity to detect new mutations, especially in the ex vivo lymphocytes.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "technical", "noise", "limits", "our", ...

PMC11727145

The exudates from the early and late collections were used purely at 100% to screen any negative effects on cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "exudates", ...

PMC9532503

Sample preparation and glycan labeling was done using the glycan labeling kit (Ludger, UK).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sample", "preparation", "and", "glycan", "labelin...

PMC9429973

In patients intended to undergo salvage therapy followed by ASCT (n=18, n=13 transplanted) or AlloSCT (n=5, all transplanted), the 2-year PFS rate and 5-year OS rate were 80% (95% CI 52-100) and 60% (95% CI 41-88), and 80% (95% CI 52-100) and 61% (95% CI 42-88), respectively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Most deaths were caused by the original disease (75.4%) with concomitant infection (5.9%) or with multiorgan failure (4.3%).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6742971

We conclude that the anti-tumor effect of adoptively transferred T cells is not hampered by the co-presence of T cells with lower avidity.

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PMC3931643

We next tested whether maintenance of the eIF4F complex in VAL cells treated with MLN0128 preserved cap dependent translation and overall protein synthesis.

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PMC5925824

Results are represented as a geometric mean of engraftment + SEM with n = 9 mice on day 18 and day 34, and n = 5 mice on day 46.

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PMC9429973

Similarly, patients with egular hospital visits had a median overall survival (OS) of 107.4months, which was also better than that of patients with irregular hospital visits (37.1 months, p < 0.001).

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PMC10529414

In summary, our results show that the overexpression of RUNX2 in lung cancer is related to its occupancy at different genomic regions, principally at intergenic regions (61%), introns (29%), and promoters-transcription start sites (TSSs) (5%).

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PMC11021472

Expression levels of circZDHHC11 in WT ST486 and the monoclonal NTCR1CR2 control and miR-150BSdel mutant cell lines were analyzed by RT-qPCR. (

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PMC11499955

These results showed that our approach can be used to profile tumor biopsies by detecting several biomarkers in one single process.

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PMC11283030

Neg: negative, Pos: positive, Meta: metastasis. *

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PMC11747885

In this assay, the 5′ open loop sequence was labelled with P-phosphate.

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PMC11746948

e GPX4 palmitoylation in A375 cells infected with lentiviruses encoding control shRNA or ZDHHC20 shRNA, and incubated with 50 μM Alk14 for 12 h, determined using the click chemistry assay.

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PMC11743316

Fig. 1 Mitochondrial abnormalities in cancer show that various elements of cancer cells can be altered.

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PMC11772585

E EdU staining assay was used to assess cell proliferation (n = 3).

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PMC11541241

The management of fungal diseases is mainly dependent on the application of fungicides, which are not suitable for sustainable agriculture, human health, and environmental safety.

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PMC11337594

n = 3) (E, F) A375 cells were exposed to lower doses of TER (0.1, 0.3 and 0.5 µg/ml) for 48 h. The cells were labeled with PI and detected by flow cytometry Although we observed cleavage of CASP3, a key protein involved in apoptosis, following TER treatment, it is important to note that knockout of CASP3 did not allevi...

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PMC10006224

Resolution is 100 kb/bin in I and 25 kb/bin in II.

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PMC9920575

The fruit of Sechium edule (Jacq.)

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PMC10698968

TEM images in Fig. 4C show, for the first time, the ultrastructural details of a primary MFS cell culture, enlightening the irregular and hypertrophic shape of MF-R 3 nucleoli.

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PMC9895440

All images are provided in the Source Data file.

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PMC11756514

The diluted mixture was dialyzed twice against 2 L loading buffer.

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PMC10809689

The α-KG reduction in the PG72 group could be due to the decrease in the amount of glutamate in the treated groups for the production of non-essential amino acids or purine and pyrimidine nucleotides for DNA synthesis in the cells, as well as the activation of the cell and the Krebs cycle .

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PMC11798926

All cell lines were grown in a humidified incubator at 37°C and 5% CO2.

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PMC11637276

d, e) Collagen I uptake index and α2 integrin internal pool were calculated with ImageJ. Values represented are normalised mean + SD from N = 3 independent experiments; ****p < 0.0001; Kruskal–Wallis test. (

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PMC11748335

Afterward, we utilized computeMatrix to determine the replication timing of each merged common PMDs with Repli-Seq data of five normal cell lines (HUVEC, IMR90, NHEK, BJ_1 and BJ_2) from UCSC database and the average signals of the quantile normalization results were obtained.

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PMC9429973

Finally, we provided the first evidence that Hh inhibitors represent a promising new therapeutic target.

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PMC9429973

Overall, 135 (77.5%) patients had been previously treated with rituximab, 33 (16.5%) of them within 12 months before vaccination.

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PMC11752740

Fa (Fraction affected)/Fu (Fraction unaffected) = (D/Dm) m, where D represents the dose required to achieve Fa, Dm is the median-effect dose, and m is the slope Combination Index plot illustrating the effects of pistachio hull extract (E) and carfilzomib (CFZ) on SK-BR3 and MCF10A cell lines at 24- and 48-hours post-tr...

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PMC9429973

Image: Summary/Conclusion: This finding underlies the central role of JAK2V617F mutation in the pathogenesis of unusual type VTE in MPN, which occurs as sole molecular alteration in more than 90% of cases.

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PMC11599565

The MET-driven conversion of cells which originally belong to the same embryonal layer, regardless of the type, has been previously reported.

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PMC11541409

This reference supports the longer time of imatinib treatment is effective and safe.

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PMC11723947

e–g Percentage of HLA-B7 WT and HP1γ KO human Tconv producing IFN-γ (e), GM-CSF (f) or Granzyme B (g).

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PMC11544122

No. 51-01-08-22 and 51-01-19-09) were from Integrated DNA Technologies (Newark, NJ).

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PMC11640555

The results of the present study demonstrated that CX-4945 displayed significant inhibition of proliferation on the U-87 cell line, indicating that U-87 cells might be sensitive to CX-4945 in terms of downregulation of CK2.

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PMC10391797

As expected, cells involved in antitumor or anti-inflammation processes, including activated CD4 memory T cells, follicular helper T cells, and activated NK cells, were significantly decreased in patients with AML (figure 1E), reflecting immune dysfunction in AML.

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PMC10975211

This approach combines different therapeutic agents, enhancing their individual properties and enabling targeted drug delivery .

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PMC9429973

At the time of MDS dx, 31 (43%) pts had t-MDS: 97%, 58% and 29% had a history of chemotherapy, radiation, and prior stem cell transplant (SCT), respectively.

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PMC11401350

Nevertheless, the anti-CD4CAR CD8 T cells will target all CD4 T cells, malignant or healthy, which might lead to some immunosuppression in the patients.

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PMC2944824

Rabbit antibodies against human hairless, mouse bcl2, (both Abcam) and mouse cytochrome C (Invitrogen) were used at 1∶100 dilution.

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PMC10808409

Total pluronics: 200 mg Pluronic P123:90% Drug amount: 8.58 mg *Prediction error = Predicted value – Observed value/Predicted value × 100.

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PMC11271800

Imatinib (STI571) was first used clinically in 2002 and achieved significant efficacy in the treatment of a patient with metastatic GI mesenchymal stromal tumor.

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PMC11055323

The green boxes indicate the newly formed long-range interaction.

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PMC11748335

Following the LOLA R package manual, we added custom target regions and conducted LOLA analysis.

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PMC11731614

The predicted protein targets for let-7 and miR-23 were obtained by cross-referencing 3 separate databases: MirDB, TargetScan, and DIANA-microT. The protein targets predicted by all three programs were used for downstream analysis.

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PMC9429973

Randomization: 2:1 to MMB 200 mg QD plus DAN placebo or DAN 600 mg QD plus MMB placebo for 24 wks, after which pts could receive open-label MMB.

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PMC11650848

A heatmap was generated comparing the two mQTLs discussed, along with three additional SNPs in close proximity.

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PMC9848491

The AUCs of 1, 3, and 5-years survival were 0.625, 0.805, and 0.79, respectively ( Figure 8A ).

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PMC8164677

Drugs targeting such checkpoints, Chk1 being one of them, are the focus of multiple clinical trials.14 Decreased accumulation of platinum drugs is one of the mechanisms of the development of resistance to the drugs by the cells.

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PMC7039683

To test this prediction, we dissected palate shelves from mouse embryos at embryonic day (E)14.5 and manually removed epithelium, both basal and periderm layers together, after brief incubation in trypsin (Figure 5A).

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PMC11754436

In the pCMV NPEPPS group (pN), NPEPPS was overexpressed using the pCMV NPEPPS vector.

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PMC11657744

Cep89 or Fbf1-depleted ciliated cells were treated with 10% fetal bovine serum to induce ciliary absorption.

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PMC10812665

The effect of normalization was checked by boxplots and distribution plots (not shown) and no outlier samples were identified.

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PMC10850553

Secondary antibodies used were as follows; Alexa Fluor 488-conjugated donkey anti-mouse IgG H&L antibody (#A21202, Thermo Fisher Scientific), Alexa Fluor 488-conjugated donkey anti-rabbit IgG H&L antibody (#A21206, Thermo Fisher Scientific), Alexa Fluor 594-conjugated donkey anti-mouse IgG H&L antibody (#A21203, Thermo...

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PMC10877303

6Two-dimensional (2D) view of the interactions between MERS-CoV 3CL and the top inhibitor (Nafamostat).Fig.

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PMC10380508

In the TCGA data analysis, we observed a correlation between the expression levels of PAX2 and PAX8 and the clinical outcomes of RCC patients.

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PMC5874706

Aliquots of the cell suspension with the respective RBC number of 5 × 10 were added to the PBS solution (pH 7.2) containing increasing concentrations of the samples investigated in the study.

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PMC11269933

Those residues with high RMSF values are labeled.(C) The time course of SASA values of the two systems.(D) The RDF values around K279 of PK.

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PMC9844987

The Random Forest model was implemented and trained in Scikit-learn (version 2.3.0) with 500 trees, a maximum depth of trees of 10, 50samples split per node, and 50samples to be at a leaf node.

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PMC11487720

In contrast, the formation of the WWOX/TRAF2 complex, plus p53, was strengthened at 37 °C required for apoptosis.

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PMC10996034

P<0.05 was considered to indicate a statistically significant difference.

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PMC11705862

Our data are consistent with these findings, as they showed marked downregulation of IRIS-1 and 2 expressions in hippocampal neurons in AD and T2D cases, compared to controls.

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PMC11585565

To examine cellular localization, the mutant and WT plasmids were transfected into a HEK293 cell line, and immunofluorescent staining was performed at 24-hours post-transfection (Fig. 2a).

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PMC11340319

A variety of demographics were collected.

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PMC11761919

Control groups included microcapsules with Fiber2-expressing E. faecalis, microcapsules with Fiber2-expressing E. faecalis and 0.01 g of inulin, and microcapsules without bacteria.

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PMC9429973

Chimeric antigen receptor T-cells (CAR-T) targeting CD19 are effective, and axicabtagene ciloleucel is currently approved by FDA for treatment of patients (pts) with relapsed FL, but toxicities like cytokine-release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) may limit its use.

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PMC11310713

Scale bars, 200 μm. (

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PMC11297139

c Representative confocal images demonstrating the colocalization pattern of recombinant ARID1A proteins (green) and SMARCB1 (red).

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PMC8073654

The binding energy calculations of the 5-LO complex with 1, 2, and zileuton (anti-asthma agent) were −29.15, −26.83, and −29.40 kcal/mol, respectively, which supports the competition between the 1 and 2 substrate inhibitors, which was the same as zileuton .

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PMC11627133

Cells were incubated with 1000 nM aptamer (incubated for 30 min), washed once with ASB and stained with 500 nM SiR (15 min prior to imaging).

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PMC11759543

This research was supported in part by the 10.13039/100020595National Science and Technology Council, Taiwan, R.O.C. (grant number NSTC112–2320-B-415-002) and SKBIO Technology Corp. (grant number Shen-1).

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PMC10419319

Collectively, these results indicate that isoalantolactone effectively regulates cisplatin-resistant cells, particularly A2780 and SNU-8 OC cells.

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PMC11650848

D prime is an indicator of allelic segregation of SNPs and ranges from 0 to 1 (0 indicates no linkage between SNP alleles, 1 represents a tight linkage of SNP alleles).

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PMC7348793

The gaps were closed by PCR-amplifying respective regions using sequencing primers and sequencing the resulting shorter fragments with additional primers (Supplementary Table S1).

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PMC9964635

It is composed of 100 μg/mL streptomycin, 100 units/mL penicillin, and 10% FBS.

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PMC11377827

HIF-1α ChIP-PCR for HREs of CA9, PHD3 and VEGF in control, HIF1β or USP43 depleted HeLa cells treated with 21 or 1% oxygen for 6 h. n = 4 biologically independent samples, mean ± sd.

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PMC11604830

The resulting spectra clearly demonstrated the presence of the nanoparticles only in the right PLN corresponding to the mouse side where the tumor lesion was located (Figure 4).

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PMC9429973

Enrichment of double positive cells by MACS and injection into NSG mice.

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PMC10747139

Recently, the combination of RAPTA-C and paclitaxel based on fructose-coated nanoparticles has been suggested as a dual drug delivery system for the treatment of metastatic cancer.

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PMC11673128

Conversely, to assess the phagocytic activity in the resistant setting, we used the AS4 cell line, which is known to carry on-target and off-target resistance mechanisms against crizotinib and lorlatinib, respectively (Table S1).

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PMC11790599

This dysregulated process, driven by accelerated macropinocytosis, contributes to abnormal cellular drinking and, ultimately, the rupture of cancer cells.

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PMC11782780

Our study provided experimental evidence to demonstrate that EBF3 knockdown considerably enhanced glycolysis in BC cells, promoting their stem-like phenotype, while the addition of 2-DG attenuated the promoting effect of EBF3 knockdown on glycolysis and cell stem-like phenotype of BC cells.

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PMC11489175

Although the preclinical efficacy of small-molecule USP7 inhibitors was demonstrated in vivo and the synergistic effect of combining USP7 inhibition with cancer immunotherapy appears promising, the field seems to be at its infancy.

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