OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11767725	Furthermore, IL-6 signaling through its receptor complex (IL-6R and gp130) activates the janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway in keratinocytes, leading to the expression of pro-inflammatory genes and a shift in AMP production.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10955424	Proteins were immunoblotted onto a nitrocellulose membrane (Schleicher & Schuell BioScience GmbH, Germany) which was then blocked with 5 % skim milk TBS/T, and incubated with the following antibodies: anti-cleaved poly-ADP-ribose polymerase (PARP) (Asp214) (D64E10, Cell Signaling Technology, dilution 1:2000), anti-α-tu...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11371747	Of further note, at pH 7.4, the effect of the drugs was much less than at pH 5.5, suggesting different transporter kinetics at each pH (Supplementary Figure S1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5535901	are rich in sulfur-containing compounds, known as glucosinolates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "are", "rich", "in", "sulfur-containing", "compounds", ",", "known", "as", "glucosinolates", "." ] } ]
PMC9429973	Methods: Adults (18-45 years old) with severe SCD (as defined by recurrent vaso-occlusive events [VOE] and acute chest syndrome) were screened for eligibility.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11674441	In brief, PBMCs, obtained via pretreatment leukapheresis, were thawed and seeded into six-well plates containing complete medium with 1% autologous serum (2 × 10⁶ cells/well in 2 mL of medium).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11266100	The fluorescence (Ex.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "The", "fluorescence", "(", "Ex", "." ] } ]
PMC11536589	The protein levels were quantified using ImageJ software.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "protein", "levels", "were", "quantified", "using", "ImageJ", "software", "." ] } ]
PMC7762347	After 24 h, no significant changes in the cell cycle were determined, while after 72 h CYN and CYN/MCLR combination at the highest concentration tested affected the cell cycle.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9250505	Cancer cells with an impaired HR repair system rely on PARP-mediated DNA repair for survival.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cancer", "cells", "with", "an", "impaired", "HR", "repair",...
PMC11700247	Two-way analysis of variance was used to compare tumor progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two-way", "analysis", "of", "variance", "was", "used", "to", "compare", "tumor", "progression", ...
PMC8481254	Scale bars: 200 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", ":", "200", "μm", "." ] } ]
PMC9429973	The CR/CRi rate was 48% with DEC and 61% with IC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "CR/CRi", "rate", "was", "48", "%", "with", "DEC", "and", ...
PMC11703896	Confirmation of rapamycin production was evidenced by the zone of inhibition against C. albicans.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Confirmation", "of", "rapamycin", "production", "was", "evidenced", "b...
PMC11753435	To do this, we propose a process to generate naturalistic peptide candidates through Gaussian perturbation of the peptidic latent space of the ESM-2 protein language model and subsequently screen these novel sequences for target-selective interaction activity via a contrastive language-image pretraining (CLIP)–based co...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9250505	For organoid culture, Matrigel (354262, Corning, US) was added to the plate and polymerized for 15 min at 37 °C, and then primary cells were mixed with growth medium supplemented with 2% FBS, 50% Matrigel (354262, Corning, USA), 1x N2 Supplement (Gibco; Thermo Fisher Scientific, Inc.), 1x B27 (Gibco; Thermo Fisher Scie...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11629143	Acetylation of nucleosomes at promoters has been associated with increasing access to general transcription factors, such as the TATA‐binding protein (TBP), by weakening the interactions between core histones and the DNA .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Median patient age was 47 years, with 90% presenting with de novo AML.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "patient", "age", "was", "47", "years", ",", ...
PMC11519788	Additionally, SPOP markedly promoted STAT3 poly-ubiquitination, an effect that was diminished when SBC motif was deleted or S514 was mutated (Figure 4L).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Aims: To determine efficacy and safety of PHE885 in adults with r/r MM who have failed ≥3 prior lines of therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", ...
PMC11779605	The results also identify candidate mechanisms of the process of ovarian cancer metastases and recurrence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "also", "identify", "candidate", "mechanisms", ...
PMC10421378	Samples for the pour plate tests were taken after 1, 2, 3, 6, 9, and 12 months of storage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10578720	Metabolomics data visualized by heatmap.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Metabolomics", "data", "visualized", "by", "heatmap", "." ] } ]
PMC11537649	We also found a negative correlation between NEAT1 and miR-152-3p expression levels (Fig. 4B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "found", "a", "negative",...
PMC11200978	However, further studies with additional LC cell models are necessary to confirm this.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "further", "studies", "with", "additional", "LC", ...
PMC3681794	This differs from the situation in lung cancer, pancreatic cancer and phaeochromocytoma cells in which hypoxic resistance to cytotoxic-induced apoptosis is reversed by PI3K inhibition , , .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11585587	Raddeanin A (RA) is a natural triterpenoid saponin compound extracted mainly from Anemone raddeana regel which was a traditional Chinese medicine to promote blood circulation, eliminate blood stasis, and treat rheumatism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8270637	Flow cytometry was used to isolate CD3+ CD8+ T cells from peripheral blood mononuclear cells and detect the fluorescence intensity of PE-conjugated PD-1 protein and FITC-conjugated CTLA-4 protein on the cell surface. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11371747	Relative affinity is defined as the inverse ratio of the amount of drug displacing 50% of [H]-FA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Relative", "affinity", "is", "defined", ...
PMC11768281	The literature search flowchart is shown in Figure 2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "literature", "search", "flowchart", "is", "shown", "in", "Figure", "2", "." ] } ]
PMC10976516	Clearance of tumor lesion and activation and proliferation of T cells; resulting in CAF targeting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Clearance", "of", "tumor", "lesion", "and", "activatio...
PMC10582828	In this commentary, we offer a simple yet plausible explanation by which SARS-2 could have been produced in a laboratory using simple, time-proven, and well-established laboratory technologies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10291556	This effect was, as expected, accompanied by a reduction in glucose consumption (Figure 3B) since intracellular lactate, which cannot be excreted into the external environment, effectively inhibits glycolysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11472639	However, complement proteins – particularly C1q, which initiates CDC – were not measured in this study but do not appear to change following 45-min of running 15% above anaerobic threshold in healthy humans (Collier-Bain et al., 2024b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	M. Mitrovic, M. Virijević, N. Pantic, Z. Pravdic, N. Sabljic, Z. Bukumiric, M. Cvetkovic, J. Rajić, M. Todorovic Balint, V. Ana, N. Suvajdzic Vukovic, D. Antic Clinic for Hematology, UCCS; Faculty of medicine, University of Belgrade, Belgrade, Serbia; Institute of medical statistics and informatics, Faculty of medicine...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9844987	Cell cultures were split every few days for maintenance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "cultures", "were", "split", "every", "few", "days", "for", "maintenance", "." ] } ]
PMC11755519	SUMOylation or small ubiquitin modifier (SUMO) binding is a key post-translational modification that regulates intracellular transport and signal transduction by mediating protein stability and subcellular localization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11188874	The majority of defined antitumor T-cell responses require proteasomal processing of intracellular proteins to generate peptides that are bound to MHC class I (MHC-I) molecules and presented to antigen-specific T cells (12).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11098378	Thus, we were interested in both determining if IpaH4 was indeed an active E3 ubiquitin ligase and uncovering the putative host substrates that it targets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11087055	Testing model of relationships between the polonaise movements, primitive streak (PS) morphogenesis, and mitosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Testing", "model", "of", "relationships", ...
PMC10243817	Total cellular protein was extracted from HNECs or BEAS-2B cells in RIPA lysis buffer containing a 2% cocktail of protease inhibitor (Guge Biotechnology).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC9429973	Methods: We investigated 42 SMZL that underwent DLBCL transformation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "We", "investigated", "42", "SMZL", "that", "underwent", "DLBCL", "transformation...
PMC8875242	There were no statistically significant differences between the ATP contents of the tested samples (Figure 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "were", "no", "statistically", ...
PMC11468365	Then, the drug molecular graph is extracted from drug SMILES by the freely open-source chemical informatics package RDKit.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "the", "drug", ...
PMC11381192	p < 0.05, p < 0.01, *p < 0.001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.05", ",", "", "", "p", "<", ...
PMC10944868	In our case, all of the synthesized compounds have high Caco-2 permeability taking into account that their predicted value is >0.90.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC9429973	Final products from the 4 PCR reactions were mixed and purified, subjected to A-tailing and ligated to Illumina-single indexed adapters.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Final", "products", ...
PMC9841531	A dilution series of compound 33 at concentrations between 50 nM and 50 μM was generated, and 10 μL of each concentration was transferred onto the plate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11731161	To confirm the effects of SEL on the degradation of XPO1 protein in MM cells, we first examined the expression levels of XPO1 protein and mRNA in NCI-H929 cells simultaneously following SEL treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11730320	The sequences were visualized using FinchTV Version 1.4.0, and were manually compared with the reference genome to determine the presence of the deletion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10719213	T cells may generally have a higher somatic mutation rate than B cells, or their clonal development may make these mutations more readily detectable .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11634027	Histogram showing distribution of phenotypes, scored as normal dextral looping (blue), or mislooped (gray).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Histogram", "showing", "dist...
PMC11657744	Chimeric mice were bred with C57/BL6N wild-type mice to confirm the germline transmission.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chimeric", "mice", "were", "bred", "with", "C57/BL6N", "wild-type", "mice",...
PMC11435360	The MRI images were analyzed using Horos imaging software, version 3.3.6.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "MRI", "images", "were", "analyzed", "using", "Horos", "imaging", "softwar...
PMC10114490	Of a total of 1139 features (m/z-Rt), only 20 (1.8%) were differentially abundant between PD and PD diHLC-T (Fig. 5E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11706776	Silencing KCNN1 expression after treatment of the cells with doxycycline also reduces the Mn quenching rate (Fig. 5E) in all three shRNA cells, compared to the shRNA CT cells, indicating decreased CCE.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11490153	Subsequently, 2.5 mL of calcium chloride solution 0.1% w/v was added, and the mixture was stirred for 40 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ...
PMC11335267	Fittingly, we show that Alx3 deficiency correlates with altered energy homeostasis, reduced food intake, and decreased muscle mass at the expense of increased adiposity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The median time to response was 8 (range, 2–24) weeks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "median", "time", "to", "response", "was", "8", "(", "range", ...
PMC11269792	p < 0.05.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.05", "." ] } ]
PMC10976516	Moreover, systemic injection of CIK cells harboring oncolytic adenoviruses in a lung tumor xenograft model led to a significant decrease in tumor load and lower levels of Ki67-expressing tumor cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4659567	As it is clearly seen from the anticipated composition of the new species detected on the water-containing solution of the representative complexes, their formation is closely related to the interaction with water (hydrolysis) and release of N-donor naza ligands.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10944868	With respect to the R substituent (in position α with respect to the cyano group), the influence of groups with fused aromatic rings such as phenanthrene is noteworthy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11529598	The tissue samples were fixed with 10% neutral formaldehyde, embedded in paraffin, and sectioned for immunohistochemical (IHC) staining as described previously .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11785489	The influence of TCR-mem persists in the absence of foreign and peripheral antigens, suggesting that TCR-mem reflects generic pMHC reactivity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "influence", ...
PMC11412721	ns: nonsignificant by Student’s t-test. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ns", ":", "nonsignificant", "by", "Student", "’s", "t-test", ".", "(" ] } ]
PMC11615743	In addition, the absence of Sgc8‐LT1‐v2, TC01‐LT2‐v2, or Sgc4f‐LT3‐v2 produced negative signals in the CEM (Figure S18, Supporting Information).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11052306	The very first example of PPH dendrimers complexing copper through pyridine–imine/hydrazone ligands and used for biological purposes concerned a series of nine dendrimers, from generation 1 (12 pyridine–imine) to generation 3 (48 pyridine–imine), functionalized with three different types of pyridine–imine groups, namel...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	After a median follow-up of 22 months (range 5-24 months), no patient died of all causes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "a", "med...
PMC6742971	Some strategies select TILs for adoptive transfer, whereas others do not select but rather use the entire TIL population for treating the melanoma patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC7685376	Table 1KEGG Enrichment Top 11 Signaling PathwayPathway DescriptionNO.P valueGENE IDRibosome131.54787E-10RPLP2/RPL17/RPL3/RPL27/RPS6/RPL19/RPL21/RPL13/RPS8/RPL18/RPL35/RPS2/RPL8Spliceosome111.88672E-08HNRNPK/HNRNPU/HNRNPA3/DDX46/PCBP1/HNRNPA1/SRSF3/HNRNPC/DDX5/HNRNPM/SRSF2Cell cycle81.99324E-05MCM5/MCM7/MCM4/CDK1/MCM6/Y...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11791203	Key genes regulating apoptosis include the tumor suppressor gene p53, the anti-apoptotic gene bcl-2, and the pro-apoptotic gene bax.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Key", "genes", "r...
PMC11682224	Angiogenesis assay results; (B) Statistics of new blood vessel formation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Angiogenesis", "assay", "results", ";", "(", "B", ")", "Statistics", ...
PMC11764090	Moreover, transient expression of a subset of ARR genes, including ARR5, ARR6, ARR7, and ARR15, which are downstream targets of EIN3, may reveal an inherent connection between cold stress and ET (Figure 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	CML patients are prone to severe infections and an increased mortality risk.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CML", "patients", "are", "prone", "to", "severe", "infections", "and", "an", ...
PMC9429973	Results: The sex ratio was 1,25 (10 M/8 F) and the mean age was 9,42 years (range 0,4y - 19y).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC4112127	The day before transfection, Mz-ChA-1 cells were plated at a density of 4×10 cells/well in six-well plates and 1.5×10 cells/well in 96-well plates.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: This study was aimed to determine whether platelet specific antibodies (including anti-GPIIb/IIIa, anti-GPIb/IX and anti-GPIa/IIa antibodies) are related to the severity of newly diagnosed pediatric ITP.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11075223	Cutting was conducive to effective ingredients for decocting, subsequent processing and clinical dose adjusting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cutting", "was", "conducive", "to", "effective", "ingredients", ...
PMC9429973	Summary/Conclusion: The survey results suggest there is a substantial time, side-effect, and HRQoL burden associated with treatment by RBCTs in patients diagnosed with TDβT. This includes considerable time devoted to preparing for and receiving transfusions, transfusion-related side effects, and increases in depression...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10047551	The cells were grown at 37 °C with 5% CO2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", "grown", "at", "37", "°", "C", "with", "5", "...
PMC11401350	The percentage of cells expressing CD69 activation marker is shown for CD8 TILs positive for the anti-CD4CAR (hCD34 +) or not (hCD34-) (mean (SD) n = 4, t-test,**p < 0.01).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11794588	The anti-cancer potential of over 3000 plants has been revealed worldwide.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "anti-cancer", "potential", "of", "over", "3000", "plants", "has", "been", "rev...
PMC11012012	Among PBL NOS and ALK+ LBCL, 82% and 50% of cases were SLAMF7/CD319-positive, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "PBL", "NOS", "and", "ALK+", ...
PMC6799808	Since caspase 8 is a crucial initiator caspase for the activation of the death receptor pathway, we first examined whether GLPT activates caspase 8.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11786156	In this study, no significant prognostic difference was observed between double-positive and non-double-positive cases, probably because of an insufficient number of cases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11610461	Interestingly, among the biological processes (BP) obtained from GO analysis, PSENEN was found to be associated with immune-related biological processes, such as humoral immune response, antimicrobial humoral response, complement activation, humoral immune response mediated by circulating immunoglobulin, and antimicrob...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11502962	The M1/M2 polarization states of macrophages play an important role in tumor progression (30).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "M1/M2", "polarization", "states", "of", "macrop...
PMC11411131	Both TrxR1-GFP and TrxR1-C-GFP exhibited a dose-dependent decrease in signal intensity upon MeHg exposure. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "TrxR1-GFP", "and", "TrxR1-C-GFP", "exhibited", "a", ...
PMC11300639	Our previous studies indicated that RNF26 is upregulated in bladder cancer, leading to tumor growth by inducing p57 instability .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "previous", "studies",...
PMC11697065	Experiments were carried out using XBridge BEH130 C18, 5 µm, 2.1 × 150 mM (Waters) column with XBridge BEH C18, 5 µm Van Guard cartridge, connected to an UltiMate 3000 Nano/Capillary LC System (Dionex).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11394730	Approximately 80% curcumin, 18% demethoxycurcumin, and 2% bis-demethoxycurcumin are present in commercial-grade turmeric.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Approximately", "80", "%", "curcumin", ...
PMC11739696	Consequently, the excessive ROS generation and substantial DNA damage induced by Co3O4NPs ultimately lead to apoptosis in melanoma A-375 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Consequently", ...
PMC9429973	The incidence of grade 5 treatment-related adverse events after HSCT was comparable in both treatment arms (25% for DEC and 22% for IC).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787355	The generated TCR-T cells were then cocultured with various target cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "generated", "TCR-T", "cells", "were", "then", "cocultured", "with", "various", ...
PMC11791264	To further investigate the pro-tumor effect of SETD7, we assessed the expression of epithelial-mesenchymal transition (EMT) markers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "further", "investigate...
PMC10955424	Additionally, Low et al. (2022) found aberrant lipid metabolism and lipolysis-promoted activity in the sera and ascites of OC patients .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additio...
PMC11322866	To make the results easier to observe, we decolorized the images using ImageJ software.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "make", "the", "results", "easier", "to", "observe", ...
PMC9031474	The increased cytotoxicity of 74a and 74b is explained by the ability to crosslink antitumor targets by pyrrole formation with lysine residues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "incre...
PMC11791203	Targeting these proteins with specific inhibitors or activators has shown promise in preclinical studies and holds potential for therapeutic interventions in colorectal cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Targeti...

PMC11767725

Furthermore, IL-6 signaling through its receptor complex (IL-6R and gp130) activates the janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway in keratinocytes, leading to the expression of pro-inflammatory genes and a shift in AMP production.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10955424

Proteins were immunoblotted onto a nitrocellulose membrane (Schleicher & Schuell BioScience GmbH, Germany) which was then blocked with 5 % skim milk TBS/T, and incubated with the following antibodies: anti-cleaved poly-ADP-ribose polymerase (PARP) (Asp214) (D64E10, Cell Signaling Technology, dilution 1:2000), anti-α-tu...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11371747

Of further note, at pH 7.4, the effect of the drugs was much less than at pH 5.5, suggesting different transporter kinetics at each pH (Supplementary Figure S1).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC5535901

are rich in sulfur-containing compounds, known as glucosinolates.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "are", "rich", "in", "sulfur-containing", "compounds", ",", "known", "as", "glucosinolates", "." ] } ]

PMC9429973

Methods: Adults (18-45 years old) with severe SCD (as defined by recurrent vaso-occlusive events [VOE] and acute chest syndrome) were screened for eligibility.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11674441

In brief, PBMCs, obtained via pretreatment leukapheresis, were thawed and seeded into six-well plates containing complete medium with 1% autologous serum (2 × 10⁶ cells/well in 2 mL of medium).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11266100

The fluorescence (Ex.

[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "The", "fluorescence", "(", "Ex", "." ] } ]

PMC11536589

The protein levels were quantified using ImageJ software.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "protein", "levels", "were", "quantified", "using", "ImageJ", "software", "." ] } ]

PMC7762347

After 24 h, no significant changes in the cell cycle were determined, while after 72 h CYN and CYN/MCLR combination at the highest concentration tested affected the cell cycle.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9250505

Cancer cells with an impaired HR repair system rely on PARP-mediated DNA repair for survival.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cancer", "cells", "with", "an", "impaired", "HR", "repair",...

PMC11700247

Two-way analysis of variance was used to compare tumor progression.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two-way", "analysis", "of", "variance", "was", "used", "to", "compare", "tumor", "progression", ...

PMC8481254

Scale bars: 200 μm.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", ":", "200", "μm", "." ] } ]

PMC9429973

The CR/CRi rate was 48% with DEC and 61% with IC.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "CR/CRi", "rate", "was", "48", "%", "with", "DEC", "and", ...

PMC11703896

Confirmation of rapamycin production was evidenced by the zone of inhibition against C. albicans.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Confirmation", "of", "rapamycin", "production", "was", "evidenced", "b...

PMC11753435

To do this, we propose a process to generate naturalistic peptide candidates through Gaussian perturbation of the peptidic latent space of the ESM-2 protein language model and subsequently screen these novel sequences for target-selective interaction activity via a contrastive language-image pretraining (CLIP)–based co...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9250505

For organoid culture, Matrigel (354262, Corning, US) was added to the plate and polymerized for 15 min at 37 °C, and then primary cells were mixed with growth medium supplemented with 2% FBS, 50% Matrigel (354262, Corning, USA), 1x N2 Supplement (Gibco; Thermo Fisher Scientific, Inc.), 1x B27 (Gibco; Thermo Fisher Scie...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11629143

Acetylation of nucleosomes at promoters has been associated with increasing access to general transcription factors, such as the TATA‐binding protein (TBP), by weakening the interactions between core histones and the DNA .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Median patient age was 47 years, with 90% presenting with de novo AML.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "patient", "age", "was", "47", "years", ",", ...

PMC11519788

Additionally, SPOP markedly promoted STAT3 poly-ubiquitination, an effect that was diminished when SBC motif was deleted or S514 was mutated (Figure 4L).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC9429973

Aims: To determine efficacy and safety of PHE885 in adults with r/r MM who have failed ≥3 prior lines of therapy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", ...

PMC11779605

The results also identify candidate mechanisms of the process of ovarian cancer metastases and recurrence.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "also", "identify", "candidate", "mechanisms", ...

PMC10421378

Samples for the pour plate tests were taken after 1, 2, 3, 6, 9, and 12 months of storage.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC10578720

Metabolomics data visualized by heatmap.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Metabolomics", "data", "visualized", "by", "heatmap", "." ] } ]

PMC11537649

We also found a negative correlation between NEAT1 and miR-152-3p expression levels (Fig. 4B).

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PMC11200978

However, further studies with additional LC cell models are necessary to confirm this.

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PMC3681794

This differs from the situation in lung cancer, pancreatic cancer and phaeochromocytoma cells in which hypoxic resistance to cytotoxic-induced apoptosis is reversed by PI3K inhibition , , .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11585587

Raddeanin A (RA) is a natural triterpenoid saponin compound extracted mainly from Anemone raddeana regel which was a traditional Chinese medicine to promote blood circulation, eliminate blood stasis, and treat rheumatism.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8270637

Flow cytometry was used to isolate CD3+ CD8+ T cells from peripheral blood mononuclear cells and detect the fluorescence intensity of PE-conjugated PD-1 protein and FITC-conjugated CTLA-4 protein on the cell surface. (

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PMC11371747

Relative affinity is defined as the inverse ratio of the amount of drug displacing 50% of [H]-FA.

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PMC11768281

The literature search flowchart is shown in Figure 2.

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PMC10976516

Clearance of tumor lesion and activation and proliferation of T cells; resulting in CAF targeting.

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PMC10582828

In this commentary, we offer a simple yet plausible explanation by which SARS-2 could have been produced in a laboratory using simple, time-proven, and well-established laboratory technologies.

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PMC10291556

This effect was, as expected, accompanied by a reduction in glucose consumption (Figure 3B) since intracellular lactate, which cannot be excreted into the external environment, effectively inhibits glycolysis.

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PMC11472639

However, complement proteins – particularly C1q, which initiates CDC – were not measured in this study but do not appear to change following 45-min of running 15% above anaerobic threshold in healthy humans (Collier-Bain et al., 2024b).

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PMC9429973

M. Mitrovic, M. Virijević, N. Pantic, Z. Pravdic, N. Sabljic, Z. Bukumiric, M. Cvetkovic, J. Rajić, M. Todorovic Balint, V. Ana, N. Suvajdzic Vukovic, D. Antic Clinic for Hematology, UCCS; Faculty of medicine, University of Belgrade, Belgrade, Serbia; Institute of medical statistics and informatics, Faculty of medicine...

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PMC9844987

Cell cultures were split every few days for maintenance.

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PMC11755519

SUMOylation or small ubiquitin modifier (SUMO) binding is a key post-translational modification that regulates intracellular transport and signal transduction by mediating protein stability and subcellular localization.

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PMC11188874

The majority of defined antitumor T-cell responses require proteasomal processing of intracellular proteins to generate peptides that are bound to MHC class I (MHC-I) molecules and presented to antigen-specific T cells (12).

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PMC11098378

Thus, we were interested in both determining if IpaH4 was indeed an active E3 ubiquitin ligase and uncovering the putative host substrates that it targets.

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PMC11087055

Testing model of relationships between the polonaise movements, primitive streak (PS) morphogenesis, and mitosis.

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PMC10243817

Total cellular protein was extracted from HNECs or BEAS-2B cells in RIPA lysis buffer containing a 2% cocktail of protease inhibitor (Guge Biotechnology).

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PMC9429973

Methods: We investigated 42 SMZL that underwent DLBCL transformation.

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PMC8875242

There were no statistically significant differences between the ATP contents of the tested samples (Figure 1).

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PMC11468365

Then, the drug molecular graph is extracted from drug SMILES by the freely open-source chemical informatics package RDKit.

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PMC11381192

p < 0.05, **p < 0.01, ***p < 0.001.

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PMC10944868

In our case, all of the synthesized compounds have high Caco-2 permeability taking into account that their predicted value is >0.90.

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PMC9429973

Final products from the 4 PCR reactions were mixed and purified, subjected to A-tailing and ligated to Illumina-single indexed adapters.

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PMC9841531

A dilution series of compound 33 at concentrations between 50 nM and 50 μM was generated, and 10 μL of each concentration was transferred onto the plate.

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PMC11731161

To confirm the effects of SEL on the degradation of XPO1 protein in MM cells, we first examined the expression levels of XPO1 protein and mRNA in NCI-H929 cells simultaneously following SEL treatment.

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PMC11730320

The sequences were visualized using FinchTV Version 1.4.0, and were manually compared with the reference genome to determine the presence of the deletion.

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PMC10719213

T cells may generally have a higher somatic mutation rate than B cells, or their clonal development may make these mutations more readily detectable .

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PMC11634027

Histogram showing distribution of phenotypes, scored as normal dextral looping (blue), or mislooped (gray).

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PMC11657744

Chimeric mice were bred with C57/BL6N wild-type mice to confirm the germline transmission.

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PMC11435360

The MRI images were analyzed using Horos imaging software, version 3.3.6.

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PMC10114490

Of a total of 1139 features (m/z-Rt), only 20 (1.8%) were differentially abundant between PD and PD diHLC-T (Fig. 5E).

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PMC11706776

Silencing KCNN1 expression after treatment of the cells with doxycycline also reduces the Mn quenching rate (Fig. 5E) in all three shRNA cells, compared to the shRNA CT cells, indicating decreased CCE.

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PMC11490153

Subsequently, 2.5 mL of calcium chloride solution 0.1% w/v was added, and the mixture was stirred for 40 min.

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PMC11335267

Fittingly, we show that Alx3 deficiency correlates with altered energy homeostasis, reduced food intake, and decreased muscle mass at the expense of increased adiposity.

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PMC9429973

The median time to response was 8 (range, 2–24) weeks.

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PMC11269792

p < 0.05.

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PMC10976516

Moreover, systemic injection of CIK cells harboring oncolytic adenoviruses in a lung tumor xenograft model led to a significant decrease in tumor load and lower levels of Ki67-expressing tumor cells.

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PMC4659567

As it is clearly seen from the anticipated composition of the new species detected on the water-containing solution of the representative complexes, their formation is closely related to the interaction with water (hydrolysis) and release of N-donor naza ligands.

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PMC10944868

With respect to the R substituent (in position α with respect to the cyano group), the influence of groups with fused aromatic rings such as phenanthrene is noteworthy.

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PMC11529598

The tissue samples were fixed with 10% neutral formaldehyde, embedded in paraffin, and sectioned for immunohistochemical (IHC) staining as described previously .

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PMC11785489

The influence of TCR-mem persists in the absence of foreign and peripheral antigens, suggesting that TCR-mem reflects generic pMHC reactivity.

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PMC11412721

ns: nonsignificant by Student’s t-test. (

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PMC11615743

In addition, the absence of Sgc8‐LT1‐v2, TC01‐LT2‐v2, or Sgc4f‐LT3‐v2 produced negative signals in the CEM (Figure S18, Supporting Information).

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PMC11052306

The very first example of PPH dendrimers complexing copper through pyridine–imine/hydrazone ligands and used for biological purposes concerned a series of nine dendrimers, from generation 1 (12 pyridine–imine) to generation 3 (48 pyridine–imine), functionalized with three different types of pyridine–imine groups, namel...

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PMC9429973

After a median follow-up of 22 months (range 5-24 months), no patient died of all causes.

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PMC6742971

Some strategies select TILs for adoptive transfer, whereas others do not select but rather use the entire TIL population for treating the melanoma patients.

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PMC7685376

Table 1KEGG Enrichment Top 11 Signaling PathwayPathway DescriptionNO.P valueGENE IDRibosome131.54787E-10RPLP2/RPL17/RPL3/RPL27/RPS6/RPL19/RPL21/RPL13/RPS8/RPL18/RPL35/RPS2/RPL8Spliceosome111.88672E-08HNRNPK/HNRNPU/HNRNPA3/DDX46/PCBP1/HNRNPA1/SRSF3/HNRNPC/DDX5/HNRNPM/SRSF2Cell cycle81.99324E-05MCM5/MCM7/MCM4/CDK1/MCM6/Y...

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PMC11791203

Key genes regulating apoptosis include the tumor suppressor gene p53, the anti-apoptotic gene bcl-2, and the pro-apoptotic gene bax.

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PMC11682224

Angiogenesis assay results; (B) Statistics of new blood vessel formation.

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PMC11764090

Moreover, transient expression of a subset of ARR genes, including ARR5, ARR6, ARR7, and ARR15, which are downstream targets of EIN3, may reveal an inherent connection between cold stress and ET (Figure 2).

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PMC9429973

CML patients are prone to severe infections and an increased mortality risk.

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PMC9429973

Results: The sex ratio was 1,25 (10 M/8 F) and the mean age was 9,42 years (range 0,4y - 19y).

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PMC4112127

The day before transfection, Mz-ChA-1 cells were plated at a density of 4×10 cells/well in six-well plates and 1.5×10 cells/well in 96-well plates.

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PMC9429973

Aims: This study was aimed to determine whether platelet specific antibodies (including anti-GPIIb/IIIa, anti-GPIb/IX and anti-GPIa/IIa antibodies) are related to the severity of newly diagnosed pediatric ITP.

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PMC11075223

Cutting was conducive to effective ingredients for decocting, subsequent processing and clinical dose adjusting.

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PMC9429973

Summary/Conclusion: The survey results suggest there is a substantial time, side-effect, and HRQoL burden associated with treatment by RBCTs in patients diagnosed with TDβT. This includes considerable time devoted to preparing for and receiving transfusions, transfusion-related side effects, and increases in depression...

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PMC10047551

The cells were grown at 37 °C with 5% CO2.

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PMC11401350

The percentage of cells expressing CD69 activation marker is shown for CD8 TILs positive for the anti-CD4CAR (hCD34 +) or not (hCD34-) (mean (SD) n = 4, t-test,**p < 0.01).

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PMC11794588

The anti-cancer potential of over 3000 plants has been revealed worldwide.

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PMC11012012

Among PBL NOS and ALK+ LBCL, 82% and 50% of cases were SLAMF7/CD319-positive, respectively.

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PMC6799808

Since caspase 8 is a crucial initiator caspase for the activation of the death receptor pathway, we first examined whether GLPT activates caspase 8.

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PMC11786156

In this study, no significant prognostic difference was observed between double-positive and non-double-positive cases, probably because of an insufficient number of cases.

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PMC11610461

Interestingly, among the biological processes (BP) obtained from GO analysis, PSENEN was found to be associated with immune-related biological processes, such as humoral immune response, antimicrobial humoral response, complement activation, humoral immune response mediated by circulating immunoglobulin, and antimicrob...

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PMC11502962

The M1/M2 polarization states of macrophages play an important role in tumor progression (30).

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PMC11411131

Both TrxR1-GFP and TrxR1-C-GFP exhibited a dose-dependent decrease in signal intensity upon MeHg exposure. (

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PMC11300639

Our previous studies indicated that RNF26 is upregulated in bladder cancer, leading to tumor growth by inducing p57 instability .

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PMC11697065

Experiments were carried out using XBridge BEH130 C18, 5 µm, 2.1 × 150 mM (Waters) column with XBridge BEH C18, 5 µm Van Guard cartridge, connected to an UltiMate 3000 Nano/Capillary LC System (Dionex).

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PMC11394730

Approximately 80% curcumin, 18% demethoxycurcumin, and 2% bis-demethoxycurcumin are present in commercial-grade turmeric.

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PMC11739696

Consequently, the excessive ROS generation and substantial DNA damage induced by Co3O4NPs ultimately lead to apoptosis in melanoma A-375 cells.

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PMC9429973

The incidence of grade 5 treatment-related adverse events after HSCT was comparable in both treatment arms (25% for DEC and 22% for IC).

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PMC11787355

The generated TCR-T cells were then cocultured with various target cells.

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PMC11791264

To further investigate the pro-tumor effect of SETD7, we assessed the expression of epithelial-mesenchymal transition (EMT) markers.

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PMC10955424

Additionally, Low et al. (2022) found aberrant lipid metabolism and lipolysis-promoted activity in the sera and ascites of OC patients .

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PMC11322866

To make the results easier to observe, we decolorized the images using ImageJ software.

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PMC9031474

The increased cytotoxicity of 74a and 74b is explained by the ability to crosslink antitumor targets by pyrrole formation with lysine residues.

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PMC11791203

Targeting these proteins with specific inhibitors or activators has shown promise in preclinical studies and holds potential for therapeutic interventions in colorectal cancer.

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