PMCID
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PMC11337594
Cells were treated with different doses of TER for 24 h, 30 h, or 48 h for flow cytometry detection.
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PMC11534377
This high mortality rate is largely due to the late stage at which lung cancer is often diagnosed, as well as the limited efficacy of conventional therapies in treating advanced-stage disease .
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PMC11529598
C. The protein expression of apoptosis symbol PARP and apoptosis suppressor Bcl-2 were detected by western blot miR-3154 prevents glioblastoma cells from apoptosis.
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PMC11711063
The chemopreventive potential of the rexinoid bexarotene has been shown in animal models, yet its clinical translation is hampered by concerns over untoward side effects.
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PMC11699042
c Heatmap comparing the status (homozygous for reference allele, alternate allele, or heterozygous) of non-synonymous SNPs in 11 A-673 strains.
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PMC10523483
Additional details for methods are provided in SI Appendix, Supplementary Methods.
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PMC11360263
HCMV infection exhibits all of the recognized characteristics associated with cancer, such as continuous signaling for cell proliferation, the disruption of cellular metabolism, resistance to apoptosis, the promotion of genetic instability, the stimulation of blood vessel formation, the initiation of invasion and metas...
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PMC9927933
The Gene Expression Profiling Interactive Analysis (GEPIA, http://gepia.cancer-pku.cn/) platform was used to determinate the gene expression differences between lung cancer and normal lung tissues.
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PMC9352806
For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
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PMC11766350
Riboswitch-mediated attenuation of transgene expression during the production stage was also shown to greatly improve the manufacturability of rAAVs containing the pro-apoptotic gene, BAX.
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PMC11423992
Our findings revealed that TFAB002s effectively lysed lymphoma B cells while demonstrating moderate increases in key cytokines such as IL-2, TNF-α, and IFN-γ.
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PMC9429973
Toxicity led to discontinuation in 18% (n=38) of patients.
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PMC5716223
a NFκB activity measurement in myoblasts and differentiating L6C5 cells (2, 5 and 9 days) grown with or without NGF supplementation.
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PMC10142392
However, the development of nanocarriers for drug delivery is a complex problem that requires a multidisciplinary approach.
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PMC11707577
The polyp body transparency allows to detect in living specimens the localization of fluorescent proteins or to follow the dynamic of the internalization of fluorescent nanosized compounds.
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PMC9429973
Median overall survival was not reached in all patients with CR.
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PMC11569208
Fluorescent foci were counted and fold change was calculated relative to control cells treated with scramble siRNA.
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PMC11628904
Briefly, subcutaneous fat was removed from the tissue, leaving the dermis intact, and uniform rectangles of 4.2 × 1.5 cm were cut from the skin.
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PMC9429973
We hypothesized that IO and the resulting oxidative stress might impair the bone marrow (BM) niche, thus interfering with the maintenance of HSCs.
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PMC11757230
Postoperative analgesia of the dogs was performed by subcutaneous injection of 20 μg/kg body weight of buprenorphine (lepetan 0.2 mg/mL; Otsuka Pharmaceutical, Tokyo, Japan) every 8 h. The adipose tissue was digested in Dulbecco's Modified Eagle's Medium (DMEM) containing 1.5 % collagenase type I (Sigma-Aldrich, St. Lo...
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PMC9429973
Response was assessed by the investigator according to IMWG criteria.
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PMC5925824
Fetal liver-derived CD34 hHSC transplanted NOG mice were implanted subcutaneously with serially-passaged OV79.FFluc2A–gfp tumor fragments (4–5 mm in diameter) at 15–17 weeks of age.
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PMC3164356
We aligned the gene sets from human, mouse and rat (Ensembl release 58) and predicted 33,635, 29,767, and 41,836 genes, respectively.
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PMC10728535
Interaction between genes that are down‐regulated in ovarian cancer cells, cisplatin resistance cell line, A2780CP, relative to cisplatin‐sensitive cell line, A2780S according to DEGs.
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PMC10482220
Transfected Cos cells were scored (100 transfected cells averaged from two experiments) for the ability of each GFP fusion to either be recruited to SGs after arsenite treatment (left column) or dominantly induce SGs assembly without treatment (right column).
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PMC8916024
Additionally, we have observed differences in food preferences between juvenile and adult C. chinensis in actual production, which may be caused by differences in the gut microbiota (Zhou et al., 2021).
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PMC11683130
Serine protease inhibitors (Serpins) is a new family proposed by Hunt et al. (1, 2) in 1980 on the basis of the conserved primary structure of ovalbumin, α1 antitrypsin, and human antithrombin.
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PMC9592219
The dysregulation of the pathway often leads to uncontrolled cell division in various cancer types .
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PMC9429973
Similarly, FLT3-ITD mutations did not confer worse outcomes (25.5 vs 20.1; p=0.464).
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PMC10391797
Data are pooled from three independent experiments and represented as the mean±SEM for each treatment group.
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PMC10079526
Our results demonstrate that this drug combination is effective to reduce lymphoma outgrowth.
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PMC10900886
HEV, high endothelial venule; red arrow, blood circulation; purple dotted arrow, potential routes of EV-D68 spread.
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PMC11737091
Finally, the stained cells were counted under a microscope.
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PMC9268620
At 72 h, there was a marked drop in the percentage of viable cells.
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PMC11547917
Nowadays, almost 50% of new drugs have been patterned after natural phytochemical compounds .
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PMC10547921
Novartis developed EG5 inhibitors 43, 44 as payloads conjugating with an antibody to target HER2 using non-lysable linkers (Fig. 8A).
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PMC11190538
The results proved the efficacy of C-phycocyanin as an antioxidant, anti-inflammatory, antitumor, and antiviral active protein, which could be investigated as a novel therapeutic option for Coronaviridae viruses such as COVID-19.
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PMC9118379
Of the 320 variant spectra obtained from sequence database searches, 179 and 111 of the variant spectra passed the similarity score thresholds of MSPIP and MSPBPI, respectively, and were considered to be high-confidence identification results (Table S10).
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PMC11025866
SLC7A11 is more functionally known as anionic amino acid transporter light chain xCT.
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PMC11128598
In all cases, CIs were below 1, indicating synergistic interactions.
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PMC10568263
However, MnO2 is hindered in electrochemical biosensing applications owing to its poor electrical conductivity and is easily oxidized.
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PMC11752767
The process starts with a tumor biopsy or surgical resection of patients with advanced melanoma.
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PMC5811757
Data were analyzed using IBM SPSS 20 (IBM, NY, USA) statistics program.
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PMC3681794
In hypoxia, hydroxylation does not occur and the alpha subunits stabilise, dimerise with HIF-1β and translocate to the nucleus where they regulate the transcription of over 100 target genes, many of which are directly or indirectly involved in drug resistance.
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PMC9429973
Considering the disease phase at diagnosis, 30 (90.9%) of patients were in chronic phase (CP), one patient (3%) in accelerated phase (AP) and two patients (6.1%) in blast crisis/ phase (BC).
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PMC11756907
The medium was then removed, and the cells were treated with test compounds for 24 hours in the system: GO in DMSOGO + 2-ME complex in DMSO 20GO in ethanolGO + 2-ME complex in ethanolrGO in DMSOrGO + 2-ME complex in DMSOrGO in ethanol 25rGO + 2-ME complex in ethanol2-ME GO in DMSO GO + 2-ME complex in DMSO 20 GO in eth...
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PMC2614416
Tryptic peptides are eluted from the micro Trap with 16 μL of 70% ACN.
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PMC9429973
In approximately 95% of adult patients, SM pathogenesis is driven by a gain-of-function mutation (D816V) in exon 17 of the KIT gene.
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PMC5034105
Indeed, our in vitro finding concurred with the recent reports of detectable viral particles and RNA in trophoblasts of the maternal and fetal placenta of ZIKV-infected type I interferon signaling-deficient mice and permissibility of placental macrophages and cytotrophoblasts to productive ZIKV infection.
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PMC9429973
After adjusting for confounding from advanced age and increasing co-morbidity burden, frailty independently predicts increased risk of all-cause mortality in ET, PV, and MF.
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PMC11082662
The three cell types tested negative for Mycoplasma, bacteria, yeast, and fungi.
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PMC11711066
It inhibits vascular calcification via estrogen receptor α, offering cardiovascular benefits.
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PMC11095939
To test this, we forced Mecp2 OE in 3T3 cells through lentiviral transduction (Figure 4E and F).
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PMC4485786
Survival was highly significantly better for NHS-IL12 cohorts compared to FcIL-7 cohort.
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PMC2193049
NA8-MEL cells (HLA-A*0201MAGE-3) were transiently transfected with the plasmids pGFP/Ub–MAGE-31–314, pGFP/Ub–MAGE-3271–279, pGFP/Ub–MAGE-3256–279, or pGFP/Ub–MAGE-3271–285 coding for the reference GFPha–Ub and either MAGE-31–314, MAGE-3271–279, MAGE-3256–279, or MAGE-3271–285, respectively (Fig. 1, constructs I–IV).
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PMC9429973
MPT and MP regimens were received in 57% and 17/40 respectively.
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PMC10170482
Emerging evidence highlights an important role of actin filaments and microtubules in controlling mitochondrial fission/fusion balance and function.
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PMC10994876
The data was imported into Prism 8.0 software (GraphPad Software Inc., La Jolla, CA, USA) for visualization, fitting, and statistical analysis.
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PMC11422150
Anti-inflammation and neuroprotective effects were observed in SCI, but whether these responses occurred only at the focal site of the SCI or the whole body was unclear.
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PMC11628904
Quantification of zone 1 photoconverted area at the indicated time, hours post‐burn (hpb).
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PMC8481254
Collectively, these results demonstrate that CDK19 promoted cellular O-GlcNAcylation of liver cancer cells in an OGT-dependent manner.
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PMC11499381
Raw Emax values were log-transformed and analyzed identically with the pEC50 values; this analytical approach considers the relative difference between Emax values within experiments rather than absolute difference .
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PMC11509224
Some compounds have very low active concentrations.
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PMC11750161
eCG consists of a common α-subunit and a hormone specific β-subunit (Min et al., 2019, 2020; Lee et al., 2021).
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PMC10813895
These biopsies encompass a mixture of epithelial, stromal, adipose, and immune cells, making them suitable for gene expression analysis through qRT-PCR .
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PMC11769516
Therefore, the potential therapeutic applications of honey in mycotoxin poisoning were investigated.
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PMC11665555
To study effect of OXCT1 on stemness, we performed a hanging drop sphere formation assay.
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PMC11047729
Camptothecin (CPT) is a cytotoxic alkaloid that can be extracted from Camptotheca acuminata.
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PMC9429973
Among the 7384 patients who survived 1 year or more after completing R-CHOP therapy, SPM occurred in a total of 493 (6.7%) patients.
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PMC10094992
ALDHs exert a protective role in cellular defence against oxidative stress and reactive oxygen species (ROS), through a NAD (P) dependent reaction of oxidation of the carbonyl groups to the corresponding carboxylic acid, to avoid the accumulation of toxic aldehydes such as acrolein, malondialdehyde (MDA), 4-hydroxy-2-n...
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PMC9325715
The analysis was performed on Shimadzu ICP-MS 2030 (Kyoto, Japan) with scandium as an internal standard.
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PMC11411004
The HDAC5 mRNA expression was significantly reduced, and HDAC5 protein expression was also detected using Western blotting (Fig. 6a, b).
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PMC9429973
This decrease is hypothesized to be caused by administered intensive chemotherapy.
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PMC10667689
Extracted total RNA (Total RNA Extraction Kit; Parstous Biotechnology, Iran) was used for cDNA synthesis (AddScript cDNA Synthesis Kit; Addbio, Sweden) in Thermal Cycler (Bio-Rad, Singapore).
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PMC11486946
Source data are provided as a Source Data file.
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PMC11047729
Vitamin E and its derivatives have been proposed in AML therapy .
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PMC11700247
This experimental approach aligns with other published works, underscoring the critical role of the STING pathway in leukocytes for the efficacy of combined RT and immunotherapy.
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PMC10170482
3D reconstruction and plane images of collagen scaffold morphology as captured by confocal microscopy.
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PMC11470381
Select Image > Stacks > Z Projection > Max intensity (or other suitable method of Z projection).
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PMC8998437
There is high DNA and protein sequence identity between these four inflammatory chemokine receptors, namely CCR1, CCR2, CCR3, and CCR5, and these receptors respond to the same inflammatory chemokine ligands .
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PMC7185206
sPD-L1 induces apoptosis in human CD8 + T cells, which can be overcome by ADAM10/ADAM17 inhibition.
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PMC11705547
MDSCs can be classified as monocytic MDSCs (M-MDSCs) and polymorphonuclear MDSCs (PMN-MDSCs) based on surface markers and morphology .
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PMC9545474
Cell survival was determined as the absorbance of treated cells divided by the absorbance of controls and expressed as a percentage.
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PMC11095939
Data are presented as means ± SEM.
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PMC11365427
Blood and BM samples were extracted in the early morning on an empty stomach and stored at −80 °C until metabolite extraction.
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PMC8414691
The full-length isoform corresponds to the ATPase catalytic subunit of the homonymous multiprotein chromatin-remodeling complex , while the shorter variants have not yet been investigated.
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PMC9429973
Finally, we performed a drug screen which targeted pathways identified through GO analysis of the transcriptomic data, targeting both oncogenic and epigenetic targets.
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PMC11638764
Interestingly, signal transducer and activator of transcription 5A (STAT5A), a key protein in the JAK/STAT signaling pathway involved in various hematological malignancies and solid tumors (Wang et al., 2023; Maurer et al., 2018) , was upregulated in the NER compartment.
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PMC11742047
Only lipids with q-value < 0.05 and VIP > 1 are shown.
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PMC9429973
Median CD 34+ cell yield was 5,2 million cells per kg body weight, plerixafor were used in 5 patients and 5 patients required more than one apheresis session.
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PMC7334607
However, given the vast genetic contingencies that lead to changes in drug response, observing said stability over many additional replicates would provide a more convincing argument for the consistent evolution of dactinomycin collateral resistance following exposure to VDC/EC.
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PMC10165258
Subsequently, they are imaged every 24 h.(B) EwS spheroids viability heatmap per day, according to and averaged in discreet concentration combinations.
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PMC9268620
The occurrence of apoptosis through nordamnacanthal and damnacanthal from M. elliptica was found to be extremely concentration- and time-dependent, but the mechanism by which they caused cell death was unknown.
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PMC6190245
The results confirmed that concomitant use of them increases radiation sensitivity and radio response of the HeLa cell line, leading to increased cell death.
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PMC3019555
Error bars indicate mean ± SEM. (
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PMC11459296
Humanized immunodeficient mouse models offer significant potential for accelerating preclinical research and clinical development of novel therapies.
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PMC11632064
In cells treated for shorter periods (6, 24, and 48 h), RSK inhibition with BI-D1870 and LJH685 resulted in reduced levels of CXCL8 in A-375 cells after 6 h, while in MeWo cells, an increase in CXCL8 was observed after 24 h with BI-D1870 only (Fig 1F).
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PMC9429973
PK and CD38 receptor occupancy results in OBDS pts are consistent with those observed in SC1400 with pump.
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PMC11298021
This study was executed under the supervision of the Ethics Committee of Zanjan University of Medical Sciences, Zanjan, Iran (IR.ZUMS.REC.1399.012).
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PMC11240571
Additionally, we have explored whether RT induces the release of exosomal PD-L1.
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