PMCID string | Sentences string | ner list |
|---|---|---|
PMC11337594 | Cells were treated with different doses of TER for 24 h, 30 h, or 48 h for flow cytometry detection. | [
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PMC11534377 | This high mortality rate is largely due to the late stage at which lung cancer is often diagnosed, as well as the limited efficacy of conventional therapies in treating advanced-stage disease . | [
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PMC11529598 | C. The protein expression of apoptosis symbol PARP and apoptosis suppressor Bcl-2 were detected by western blot miR-3154 prevents glioblastoma cells from apoptosis. | [
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PMC11711063 | The chemopreventive potential of the rexinoid bexarotene has been shown in animal models, yet its clinical translation is hampered by concerns over untoward side effects. | [
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PMC11699042 | c Heatmap comparing the status (homozygous for reference allele, alternate allele, or heterozygous) of non-synonymous SNPs in 11 A-673 strains. | [
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PMC10523483 | Additional details for methods are provided in SI Appendix, Supplementary Methods. | [
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PMC11360263 | HCMV infection exhibits all of the recognized characteristics associated with cancer, such as continuous signaling for cell proliferation, the disruption of cellular metabolism, resistance to apoptosis, the promotion of genetic instability, the stimulation of blood vessel formation, the initiation of invasion and metas... | [
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PMC9927933 | The Gene Expression Profiling Interactive Analysis (GEPIA, http://gepia.cancer-pku.cn/) platform was used to determinate the gene expression differences between lung cancer and normal lung tissues. | [
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PMC9352806 | For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.) | [
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PMC11766350 | Riboswitch-mediated attenuation of transgene expression during the production stage was also shown to greatly improve the manufacturability of rAAVs containing the pro-apoptotic gene, BAX. | [
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PMC11423992 | Our findings revealed that TFAB002s effectively lysed lymphoma B cells while demonstrating moderate increases in key cytokines such as IL-2, TNF-α, and IFN-γ. | [
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PMC9429973 | Toxicity led to discontinuation in 18% (n=38) of patients. | [
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PMC5716223 | a NFκB activity measurement in myoblasts and differentiating L6C5 cells (2, 5 and 9 days) grown with or without NGF supplementation. | [
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PMC10142392 | However, the development of nanocarriers for drug delivery is a complex problem that requires a multidisciplinary approach. | [
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PMC11707577 | The polyp body transparency allows to detect in living specimens the localization of fluorescent proteins or to follow the dynamic of the internalization of fluorescent nanosized compounds. | [
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PMC9429973 | Median overall survival was not reached in all patients with CR. | [
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PMC11569208 | Fluorescent foci were counted and fold change was calculated relative to control cells treated with scramble siRNA. | [
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PMC11628904 | Briefly, subcutaneous fat was removed from the tissue, leaving the dermis intact, and uniform rectangles of 4.2 × 1.5 cm were cut from the skin. | [
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PMC9429973 | We hypothesized that IO and the resulting oxidative stress might impair the bone marrow (BM) niche, thus interfering with the maintenance of HSCs. | [
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PMC11757230 | Postoperative analgesia of the dogs was performed by subcutaneous injection of 20 μg/kg body weight of buprenorphine (lepetan 0.2 mg/mL; Otsuka Pharmaceutical, Tokyo, Japan) every 8 h. The adipose tissue was digested in Dulbecco's Modified Eagle's Medium (DMEM) containing 1.5 % collagenase type I (Sigma-Aldrich, St. Lo... | [
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PMC9429973 | Response was assessed by the investigator according to IMWG criteria. | [
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PMC5925824 | Fetal liver-derived CD34 hHSC transplanted NOG mice were implanted subcutaneously with serially-passaged OV79.FFluc2A–gfp tumor fragments (4–5 mm in diameter) at 15–17 weeks of age. | [
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PMC3164356 | We aligned the gene sets from human, mouse and rat (Ensembl release 58) and predicted 33,635, 29,767, and 41,836 genes, respectively. | [
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PMC10728535 | Interaction between genes that are down‐regulated in ovarian cancer cells, cisplatin resistance cell line, A2780CP, relative to cisplatin‐sensitive cell line, A2780S according to DEGs. | [
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PMC10482220 | Transfected Cos cells were scored (100 transfected cells averaged from two experiments) for the ability of each GFP fusion to either be recruited to SGs after arsenite treatment (left column) or dominantly induce SGs assembly without treatment (right column). | [
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PMC8916024 | Additionally, we have observed differences in food preferences between juvenile and adult C. chinensis in actual production, which may be caused by differences in the gut microbiota (Zhou et al., 2021). | [
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PMC11683130 | Serine protease inhibitors (Serpins) is a new family proposed by Hunt et al. (1, 2) in 1980 on the basis of the conserved primary structure of ovalbumin, α1 antitrypsin, and human antithrombin. | [
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PMC9592219 | The dysregulation of the pathway often leads to uncontrolled cell division in various cancer types . | [
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PMC9429973 | Similarly, FLT3-ITD mutations did not confer worse outcomes (25.5 vs 20.1; p=0.464). | [
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PMC10391797 | Data are pooled from three independent experiments and represented as the mean±SEM for each treatment group. | [
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PMC10079526 | Our results demonstrate that this drug combination is effective to reduce lymphoma outgrowth. | [
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PMC10900886 | HEV, high endothelial venule; red arrow, blood circulation; purple dotted arrow, potential routes of EV-D68 spread. | [
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PMC11737091 | Finally, the stained cells were counted under a microscope. | [
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PMC9268620 | At 72 h, there was a marked drop in the percentage of viable cells. | [
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PMC11547917 | Nowadays, almost 50% of new drugs have been patterned after natural phytochemical compounds . | [
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PMC10547921 | Novartis developed EG5 inhibitors 43, 44 as payloads conjugating with an antibody to target HER2 using non-lysable linkers (Fig. 8A). | [
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PMC11190538 | The results proved the efficacy of C-phycocyanin as an antioxidant, anti-inflammatory, antitumor, and antiviral active protein, which could be investigated as a novel therapeutic option for Coronaviridae viruses such as COVID-19. | [
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PMC9118379 | Of the 320 variant spectra obtained from sequence database searches, 179 and 111 of the variant spectra passed the similarity score thresholds of MSPIP and MSPBPI, respectively, and were considered to be high-confidence identification results (Table S10). | [
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PMC11025866 | SLC7A11 is more functionally known as anionic amino acid transporter light chain xCT. | [
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PMC11128598 | In all cases, CIs were below 1, indicating synergistic interactions. | [
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PMC10568263 | However, MnO2 is hindered in electrochemical biosensing applications owing to its poor electrical conductivity and is easily oxidized. | [
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PMC11752767 | The process starts with a tumor biopsy or surgical resection of patients with advanced melanoma. | [
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PMC5811757 | Data were analyzed using IBM SPSS 20 (IBM, NY, USA) statistics program. | [
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PMC3681794 | In hypoxia, hydroxylation does not occur and the alpha subunits stabilise, dimerise with HIF-1β and translocate to the nucleus where they regulate the transcription of over 100 target genes, many of which are directly or indirectly involved in drug resistance. | [
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PMC9429973 | Considering the disease phase at diagnosis, 30 (90.9%) of patients were in chronic phase (CP), one patient (3%) in accelerated phase (AP) and two patients (6.1%) in blast crisis/ phase (BC). | [
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... |
PMC11756907 | The medium was then removed, and the cells were treated with test compounds for 24 hours in the system: GO in DMSOGO + 2-ME complex in DMSO 20GO in ethanolGO + 2-ME complex in ethanolrGO in DMSOrGO + 2-ME complex in DMSOrGO in ethanol 25rGO + 2-ME complex in ethanol2-ME GO in DMSO GO + 2-ME complex in DMSO 20 GO in eth... | [
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PMC2614416 | Tryptic peptides are eluted from the micro Trap with 16 μL of 70% ACN. | [
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PMC9429973 | In approximately 95% of adult patients, SM pathogenesis is driven by a gain-of-function mutation (D816V) in exon 17 of the KIT gene. | [
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PMC5034105 | Indeed, our in vitro finding concurred with the recent reports of detectable viral particles and RNA in trophoblasts of the maternal and fetal placenta of ZIKV-infected type I interferon signaling-deficient mice and permissibility of placental macrophages and cytotrophoblasts to productive ZIKV infection. | [
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PMC9429973 | After adjusting for confounding from advanced age and increasing co-morbidity burden, frailty independently predicts increased risk of all-cause mortality in ET, PV, and MF. | [
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PMC11082662 | The three cell types tested negative for Mycoplasma, bacteria, yeast, and fungi. | [
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PMC11711066 | It inhibits vascular calcification via estrogen receptor α, offering cardiovascular benefits. | [
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PMC11095939 | To test this, we forced Mecp2 OE in 3T3 cells through lentiviral transduction (Figure 4E and F). | [
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PMC4485786 | Survival was highly significantly better for NHS-IL12 cohorts compared to FcIL-7 cohort. | [
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PMC2193049 | NA8-MEL cells (HLA-A*0201MAGE-3) were transiently transfected with the plasmids pGFP/Ub–MAGE-31–314, pGFP/Ub–MAGE-3271–279, pGFP/Ub–MAGE-3256–279, or pGFP/Ub–MAGE-3271–285 coding for the reference GFPha–Ub and either MAGE-31–314, MAGE-3271–279, MAGE-3256–279, or MAGE-3271–285, respectively (Fig. 1, constructs I–IV). | [
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PMC9429973 | MPT and MP regimens were received in 57% and 17/40 respectively. | [
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PMC10170482 | Emerging evidence highlights an important role of actin filaments and microtubules in controlling mitochondrial fission/fusion balance and function. | [
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PMC10994876 | The data was imported into Prism 8.0 software (GraphPad Software Inc., La Jolla, CA, USA) for visualization, fitting, and statistical analysis. | [
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PMC11422150 | Anti-inflammation and neuroprotective effects were observed in SCI, but whether these responses occurred only at the focal site of the SCI or the whole body was unclear. | [
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PMC11628904 | Quantification of zone 1 photoconverted area at the indicated time, hours post‐burn (hpb). | [
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PMC8481254 | Collectively, these results demonstrate that CDK19 promoted cellular O-GlcNAcylation of liver cancer cells in an OGT-dependent manner. | [
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PMC11499381 | Raw Emax values were log-transformed and analyzed identically with the pEC50 values; this analytical approach considers the relative difference between Emax values within experiments rather than absolute difference . | [
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PMC11509224 | Some compounds have very low active concentrations. | [
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PMC11750161 | eCG consists of a common α-subunit and a hormone specific β-subunit (Min et al., 2019, 2020; Lee et al., 2021). | [
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PMC10813895 | These biopsies encompass a mixture of epithelial, stromal, adipose, and immune cells, making them suitable for gene expression analysis through qRT-PCR . | [
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PMC11769516 | Therefore, the potential therapeutic applications of honey in mycotoxin poisoning were investigated. | [
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PMC11665555 | To study effect of OXCT1 on stemness, we performed a hanging drop sphere formation assay. | [
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PMC11047729 | Camptothecin (CPT) is a cytotoxic alkaloid that can be extracted from Camptotheca acuminata. | [
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PMC9429973 | Among the 7384 patients who survived 1 year or more after completing R-CHOP therapy, SPM occurred in a total of 493 (6.7%) patients. | [
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PMC10094992 | ALDHs exert a protective role in cellular defence against oxidative stress and reactive oxygen species (ROS), through a NAD (P) dependent reaction of oxidation of the carbonyl groups to the corresponding carboxylic acid, to avoid the accumulation of toxic aldehydes such as acrolein, malondialdehyde (MDA), 4-hydroxy-2-n... | [
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... |
PMC9325715 | The analysis was performed on Shimadzu ICP-MS 2030 (Kyoto, Japan) with scandium as an internal standard. | [
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PMC11411004 | The HDAC5 mRNA expression was significantly reduced, and HDAC5 protein expression was also detected using Western blotting (Fig. 6a, b). | [
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PMC9429973 | This decrease is hypothesized to be caused by administered intensive chemotherapy. | [
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PMC10667689 | Extracted total RNA (Total RNA Extraction Kit; Parstous Biotechnology, Iran) was used for cDNA synthesis (AddScript cDNA Synthesis Kit; Addbio, Sweden) in Thermal Cycler (Bio-Rad, Singapore). | [
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PMC11486946 | Source data are provided as a Source Data file. | [
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PMC11047729 | Vitamin E and its derivatives have been proposed in AML therapy . | [
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PMC11700247 | This experimental approach aligns with other published works, underscoring the critical role of the STING pathway in leukocytes for the efficacy of combined RT and immunotherapy. | [
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PMC10170482 | 3D reconstruction and plane images of collagen scaffold morphology as captured by confocal microscopy. | [
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PMC11470381 | Select Image > Stacks > Z Projection > Max intensity (or other suitable method of Z projection). | [
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... |
PMC8998437 | There is high DNA and protein sequence identity between these four inflammatory chemokine receptors, namely CCR1, CCR2, CCR3, and CCR5, and these receptors respond to the same inflammatory chemokine ligands . | [
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PMC7185206 | sPD-L1 induces apoptosis in human CD8 + T cells, which can be overcome by ADAM10/ADAM17 inhibition. | [
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PMC11705547 | MDSCs can be classified as monocytic MDSCs (M-MDSCs) and polymorphonuclear MDSCs (PMN-MDSCs) based on surface markers and morphology . | [
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PMC9545474 | Cell survival was determined as the absorbance of treated cells divided by the absorbance of controls and expressed as a percentage. | [
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"O",
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... |
PMC11095939 | Data are presented as means ± SEM. | [
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PMC11365427 | Blood and BM samples were extracted in the early morning on an empty stomach and stored at −80 °C until metabolite extraction. | [
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PMC8414691 | The full-length isoform corresponds to the ATPase catalytic subunit of the homonymous multiprotein chromatin-remodeling complex , while the shorter variants have not yet been investigated. | [
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PMC9429973 | Finally, we performed a drug screen which targeted pathways identified through GO analysis of the transcriptomic data, targeting both oncogenic and epigenetic targets. | [
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PMC11638764 | Interestingly, signal transducer and activator of transcription 5A (STAT5A), a key protein in the JAK/STAT signaling pathway involved in various hematological malignancies and solid tumors (Wang et al., 2023; Maurer et al., 2018) , was upregulated in the NER compartment. | [
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PMC11742047 | Only lipids with q-value < 0.05 and VIP > 1 are shown. | [
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... |
PMC9429973 | Median CD 34+ cell yield was 5,2 million cells per kg body weight, plerixafor were used in 5 patients and 5 patients required more than one apheresis session. | [
{
"tags": [
"O",
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"O",
... |
PMC7334607 | However, given the vast genetic contingencies that lead to changes in drug response, observing said stability over many additional replicates would provide a more convincing argument for the consistent evolution of dactinomycin collateral resistance following exposure to VDC/EC. | [
{
"tags": [
"O",
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"O",
"O",
... |
PMC10165258 | Subsequently, they are imaged every 24 h.(B) EwS spheroids viability heatmap per day, according to and averaged in discreet concentration combinations. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
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"O"
],
"tokens": [
... |
PMC9268620 | The occurrence of apoptosis through nordamnacanthal and damnacanthal from M. elliptica was found to be extremely concentration- and time-dependent, but the mechanism by which they caused cell death was unknown. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
"O",
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"O",
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"O",
"O",
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"O",
"O",
... |
PMC6190245 | The results confirmed that concomitant use of them increases radiation sensitivity and radio response of the HeLa cell line, leading to increased cell death. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
"O",
"O",
"O",
"B-CellLine",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],... |
PMC3019555 | Error bars indicate mean ± SEM. ( | [
{
"tags": [
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"O",
"O",
"O"
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]
}
] |
PMC11459296 | Humanized immunodeficient mouse models offer significant potential for accelerating preclinical research and clinical development of novel therapies. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
"O",
"O",
"O",
"O"
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"tokens": [
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... |
PMC11632064 | In cells treated for shorter periods (6, 24, and 48 h), RSK inhibition with BI-D1870 and LJH685 resulted in reduced levels of CXCL8 in A-375 cells after 6 h, while in MeWo cells, an increase in CXCL8 was observed after 24 h with BI-D1870 only (Fig 1F). | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... |
PMC9429973 | PK and CD38 receptor occupancy results in OBDS pts are consistent with those observed in SC1400 with pump. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"PK",
"and",
"CD38",
"receptor",
"occup... |
PMC11298021 | This study was executed under the supervision of the Ethics Committee of Zanjan University of Medical Sciences, Zanjan, Iran (IR.ZUMS.REC.1399.012). | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
... |
PMC11240571 | Additionally, we have explored whether RT induces the release of exosomal PD-L1. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
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"O",
"O"
],
"tokens": [
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",",
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... |
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