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OTAR3088
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BioData-CellLine_annotated

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PMC11765243
Here, we analyzed a mouse model of the Cre-dependent functional inactivation of p110α (kinase dead) in T lymphocytes (p110αKD-T, KD).
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PMC7987994
We evaluated the metabolic activity of the cells using the resazurin test.
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PMC9429973
To analyze the genome complexity associated with chromothripsis and the patterns of rearrangements detected by OGM; 2.
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PMC9429973
A minimum of 2 HIDAC courses and a maximum of 4 courses were usually planned.
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PMC9587866
They have identified the upregulation of EYA3 by EWS-FLI fusion protein, expediting cell division and tumor growth.
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PMC11770746
injection of the various compounds. (
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PMC10669966
No. C0737, Sigma–Aldrich), and DNMDP (CAS No. 328104-79-6, Cat.
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PMC9429973
The starting dose of eltrombopag was 25 mg/day, which increased by 25 mg/day every 2 wks based on the total platelet count, up to a maximum dose of 150 mg/day.
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PMC9444294
Instead, attempts to disentangle the roles of SS18-SSX from SS18 have often relied on the knockdown of the fusion oncoprotein using shRNA directed against the SSX regions, an approach limited to cell line models.11 Immunoprecipitation-based studies have transfected epitope-tagged versions of SS18-SSX (eg, TAP, HA) to p...
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PMC9429973
Cancer patients in terminal stages present symptoms related to anemia, other cytopenias and coagulopathies that deteriorate the quality of life.1,2 These symptoms can be multicausal and do not improve in most cases with a single medical intervention.
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PMC9250505
As observed in Fig. 1A, higher levels of pBADS99 positively correlated with higher labeling of Ki67 (ρ = 0.274, p = 0.014*) and higher International Federation of Gynecology and Obstetrics (FIGO) stage (ρ = 0.629, p < 0.001***) (Fig. 1A).
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PMC9351137
Cells were stained with DAPI (blue) and anti-α-tubulin (green).
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PMC11449273
Cell pellets from 100 mm cultures were extracted with NE-PER™ Nuclear and Cytoplasmic Extraction Reagents (Thermo Scientific) according to the manufacturer’s protocol.
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PMC9429973
B. Merchan Muñoz, D. Subirá Pérez, M. I. Nuevo Lopez, M. Mora Argumanez, R. Pérez Alonso, A. Vazquez Ramo, A. Gil Perez, H. Guillen Garcia, J. Arbeteta Juanis, A. B. Santos Montero, N. Golbano Lopez, S. Herrero Lopez, M. D. Morales Sanz, D. De Miguel Llorente Haematology, Hospital Universitario Guadalajara, Guadalajara...
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PMC10376064
In order to substantiate our findings, we sought to functionally assess the capability of DMF to reverse ABCC1-mediated multi-drug resistance (MDR) by applying a 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide-(MTT)-based cell viability assay.
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PMC11528603
Briefly, AM treated breast cancer cells exhibited the up-regulation of caspase-8, death receptors, and their respective ligands, all of which are crucial markers of the extrinsic cascade.
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PMC11594641
Exosomes are endosomal-originating membranous vesicles that range from ~30 to 200 nm in diameter.
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PMC9429973
MM/MGUS patients additionally had standard myeloma bloods and Dual-Energy X-ray Absorptiometry (DXA) at each visit, as correlates of tumour burden and bone loss.
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PMC9429973
Statistical analysis was performed using the Kaplan Meier method.
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PMC11587541
In conclusion, telomere shortening has been implicated in the pathogenesis of SMA.
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PMC11621565
Representative image of triplicate wells.
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PMC9429973
F. Kallel, K. Mezghani, N. Siala, Y. Fakhfekh, L. Khalifa, S. Hadiji, O. Kassar, I. Frikha, I. Ben Amor, M. Charfi, D. Balloumi, L. Torjmen, K. Kammoun, M. Ben Hamida, T. Ben Othmen, M. Medhaffar, M. Elloumi Clinical Hematology, Hedi Chaker Hospital, Sfax; National Bone Marrow Transplant Center, Tunis; Nephrology, Hedi...
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PMC9429973
In terms of anemia subgroups, positive anti-Ro52 was a potential risk factor for microcytic anemia, but a protective factor for normocytic anemia.
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PMC8303372
Therefore, in this preliminary phase of the experiments a steady increase of the electrical resistance is expected.
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PMC9454178
Antibodies against GAPDH (60004–1-Ig) and Caspase-3 (19677–1-AP) and HRP-conjugated secondary antibodies (SA00001-1 and SA00001-2) were purchased from Proteintech (Wuhan, China).
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PMC11471176
LS, Shanghai, China) with the same supplements.
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PMC6461034
Third, for HCC827‐ER3, a subline of HCC827 expressing mutant EGFR but exhibiting in vivo acquired resistance to the EGFR inhibitor erlotinib (Zhang et al, 2012), INKA inferred high activity of EGFR and MET (Figs 2C and 3C).
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PMC9926039
Furthermore, the stimulation and activation of TLR4 could invoke the production of pro-inflammatory cytokines and mediators against pathogens.
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PMC10237474
Peaks next to the full-length protein 3 have a mass difference of 15 Da.
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PMC6889484
These results suggest that the NL4-3[SEMQ] mutant can overcome the antiviral activity of A3G-D128K, but it either is less efficient at inducing A3G-D128K degradation or has a lower fitness than wild-type NL4-3.Figure 6Replication Kinetics of the NL4-3 Vif SEMQ Mutant in CEM/D128K and CEMSS/D128K Cell Lines(A–D) Normali...
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PMC11638288
They demonstrated that NK cells accumulate in the inflamed chamber upon attack by F. nucleatum and Porphyromonas gingivalis triggered the secretion of TNF-α, and the presence of TNF-α in the chamber depended on NCR1.
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PMC10887351
β2-Ars’ activation induces bronchodilation and muscle relaxation, redirecting the blood flow and mobilizing energy accumulation .
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PMC9429973
As expected, the repertoire of healthy B cells in the blood of IGLV3-21 CLL patients contained IGLV3-21 light chains with the wild-type G110 residue, indicating that the R110 exchange is of acquired nature.
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PMC9429973
d1-5 and 8-9 every cycle) for the treatment of adult patients diagnosed with AML, as per WHO 2016 classification, who have not received prior treatment and are ineligible for intensive chemotherapy.
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PMC11786767
The long N-terminal domain of Ki-67 is excluded from chromatin, whereas its short C-terminal LR domain displays strong attraction to chromatin (22).
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PMC5673955
Data are presented as mean activity ± SEM.
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PMC8992508
The presence of a 4’-methoxy group on ring A of the chalcone moiety leads to an increased inhibitory activity toward BCRP in comparison with the unsubstituted series.
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PMC11344246
For each score, N proteins were ranked from 1 – N (largest score being rank N) meaning that a larger rank product score indicated a more important protein.
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PMC11781181
DHA also represents a promising therapeutic agent to induce ferroptosis 37.
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PMC11772449
The combination has certain toxic and side effects, and more research is needed to determine the strategy (especially the dose) and safety of the combination before clinical application.
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PMC11777207
Unless otherwise noted, all flow cytometry antibodies were purchased from BioLegend.
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PMC9429973
The registry is composed of a developed digital platform that collects, manages, and analyzes the data.
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PMC9926039
Treatment of breast cancer cells by morphine might change the TLR4 gene expression.
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PMC11592008
Total RNA was extracted using an RNeasy Mini Kit (Cat#74104; QIAGEN, Hamburg, Germany) following the manufacturer’s protocol.
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PMC10877303
A grid box with center points specified as X = −26.99, Y = 12.6039, Z = 58.9455, and dimensions noted as X = 50.3334, Y = 67.2744, Z = 59.2586 (each in Angstrom) was created after ligand and protein preparation using Autodock Vina.
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PMC9429973
Methods: We enrolled 60 patients with sideropenic anemia due to gastrointestinal bleeding, of whom 40 affected by documented COVID19 infection only with mild form with fever, diarrhea, bone or muscle pain or flu-like syndrome.
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PMC11471176
We selected these ranges for carnosine on the basis of previously reported ranges by other researchers .
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PMC11583010
This differential binding was supported by in vitro data investigating nectin-4–expressing tumor cell lines versus keratinocytes from healthy donors, including flow cytometry–based extracellular staining, IHC on frozen tissues, fluorescence-based evaluation of internalization, and, most importantly, in vitro cytotoxici...
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PMC11240571
In our research, exosomal PD-L1 derived from sarcomas implanted in mice was observed in blood, and we successfully demonstrated that sarcomas can be a supplier of circulating exosomal PD-L1 in vivo.
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PMC11026382
Linear regression was performed using scikit Learn, and individual points were weighted by the number of counts (in order to down weight less-sampled mutants at later time points).
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PMC11806613
Right, GPX levels.
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PMC11361748
TAR does not occur when the second stress (TPA or UVB) is administered at 48 h, instead of 24 h, after the initial TPA priming event.
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PMC8358006
HEK293T cells were purchased from the ATCC.
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PMC11746942
F Schematic diagram illustrating the positive feedback loop between S1PR3 and STAT3 in psoriatic keratinocytes.
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PMC9429973
Methods: An analysis was made of patients after HSCT with active coronavirus infection from 2020 to 2021, hospitalized in the hematology department of the Moscow multidisciplinary hospital (the hospital was completely redesigned to work on the COVID19 profile).
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PMC10589262
Additionally, investigating the relationship between BLZF1 and ATF6 would provide valuable insights into their cooperative roles in GIST pathogenesis.
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PMC11087055
Scale bars: 500μm.
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PMC11615101
Seventeen interacting proteins were identified with α-Taxilin, and in silico study suggested that glycolysis and gluconeogenesis pathways are the most affected pathways regulated by α-Taxilin.
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PMC7185206
Similar analyses were performed on all other TCGA cancer subsets (Supplemental Figure 1b, Supplemental Table 2).
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PMC11658074
AT-EVs are crucial mediators through which AT exerts regulatory effects for paracrine and endocrine functions .
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PMC11757230
The pellets were resuspended in DMEM, filtered through a 100-μm nylon mesh, and centrifuged at 400×g for 5 min to remove residue in the supernatant.
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PMC11354239
The quantity and the integrity of RNA samples were initially estimated using the NanoDrop spectrophotometer and electrophoresis on ethidium bromide-stained 1% agarose gel, respectively.
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PMC10858941
Live cells are marked in green and dead cells in red.
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PMC11802855
After 6 days of co-culture, TRAP staining was performed to assess osteoclast formation.
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PMC11321678
Immune cells were annotated using Seurat label‐transfer prediction scores with the scRNA‐seq clusters as a reference annotation.
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PMC3203927
Transcriptomic findings such as those in the above examples have been further substantiated by studies at the protein level.
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PMC11656657
Friedman matched paired test was applied to compare different cell culture conditions, while Wilcoxon matched-pairs signed-rank test was used for group’s comparison with respect to the absolute number quantified before culture (day0); p values are indicated in the graphs *#: p < 0.05. (
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PMC11518702
These pY sites then become docking sites for SYK kinase.
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PMC11742864
Numerous studies demonstrated that patients with lung cancer had significant abnormalities of lipid metabolism, including the biosynthesis of unsaturated FAs.
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PMC11754436
The target miRNA of DHRS4-AS1 was predicted using StarBase (Version 2.0, https://starbase.sysu.edu.cn/starbase2/index.php) and compared with the upregulated miRNAs in the GSE28423 dataset.
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PMC4360730
Each annotated term in the experiment maps, through relationships in the ontology, to the middle terms.
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PMC11297139
Similar to our observations with A673 cell line, we discovered that a decrease in the phase separation of ARID1A resulting from the knockdown (KD) led to a reduction in the oncogenic capabilities of the SK-N-MC cells as well (Supplementary Fig. 8c, d).
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PMC11765678
This indicates that ER does not inhibit translation or change degradation (steady state/half-life) of the ABC-transporter proteins in these cell lines.
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PMC9895440
Statistics are pairwise 2-way ANOVAs followed by Bonferroni correction.
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PMC11306331
n = 148 cells pooled from three biological replicates.
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PMC11194678
A cell with more than two obvious fluorescence puncta was counted as a puncta-positive cell.
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PMC9429973
Overall, 8 pts (32%) achieved CR and 16 (64%) had PR at any visit from Wk 6–12.
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PMC10094992
Anti-tumoural neutrophils can directly kill tumour cells, support T cell recruitment and antitumour activity, and suppress T-reg cell differentiation .
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PMC10940855
All Vk*MYC studies were done in mice in a C57BL/6 background.
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PMC11789597
MM1S cells expressing shNC or shCAV1 were treated with Baf‐A1 (5 nM) for 48 h and the protein level of p62 and LC3‐I/II was detected using western blot.
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PMC11585254
The following day, cells were rinsed twice with 500 μl warm DMEM supplemented with 20 mM HEPES, pH 7.5, and incubated with 250 μl of the same medium for 30 minutes at 37°C.
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PMC9436459
At non-toxic concentrations, kuwanon X (58) possessed prominent activities against herpes simplex virus type 1 and 2 (HSV-1 and HSV-2).
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PMC11738017
Tumor sensitivity to anti-BCMA TCEs may be restored by the use of GSIs, reducing tumor bulk by other anti-MM agents or non-BCMA-targeting TCE or CAR T therapy, and by enhancing T-cell activity through immunomodulatory drugs.
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PMC9429973
Primary endpoint analyses showed splenic and symptom responses in 68% and 56% of 84 enrolled patients, respectively.
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PMC11471176
Table 3% Survival in MTT assay for the different cell lines at carnosine concentrations ranging from ∼2 mM to ∼530 mM (Mean ± Standard Deviation).Table 3ConcentrationMCF-7MDA-MB-231EMT-6Vero1.885.3 ± 6.180.4 ± 0.162.3 ± 15.979.4 ± 8.42.783.5 ± 11.592.2 ± 3.276.3 ± 8.386.4 ± 2.43.586.9 ± 10.990.8 ± 8.950 ± 3.186.5 ± 7.7...
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PMC11397654
Boc-protected sulfonamides were then converted into quaternary ammonium salts.
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PMC11731161
Half-maximal inhibitory concentration (IC50) was determined using GraphPad Prism 8.0.
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PMC11544771
Thus, Chk1 has been recognized as a promising target for cancer therapy.
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PMC11687663
The predicted half-life (T1/2) of all the phytoconstituents was low (less than 3 hours) (Table 4).
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PMC11490153
Citral, in particular, has shown potential in breast cancer treatment as a natural ALDH1A inhibitor, blocking the enzyme aldehyde dehydrogenase 1 A, which plays a role in breaking down toxins and chemicals .
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PMC11453018
Visualization tools employed included ComplexHeatmap (version 2.4.3), clusterProfiler (version 3.16.1), UpsetR (version 1.4), and ggplot2 (version 3.3.2).
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PMC7553912
The isotype controls are shown as red dots (upper panels) and red areas (middle and lower panels). (
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PMC9672323
Nonsteroidal anti-inflammatory drugs (NSAIDs) are a range of medications prescribed to relieve pain, fever, and inflammation.
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PMC11661040
Total cellular proteins were extracted with radioimmunoprecipitation assay (RIPA, Servicebio Technology, China).
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PMC9780037
A critical limitation of protein-based therapeutic delivery systems is the thermal stability of the protein, which limits its actual potential.
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PMC10940855
In summary, we have provided anatomic and functional evidence that suggests the importance of EPHB4–Ephrin B2 reverse signaling in EC-mediated regulation of multiple myeloma pathogenesis.
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PMC11766174
In addition, for in vitro characterization of p27 CA-ICC, PBMCs were isolated from uninfected rhesus macaques’ blood, activated with 5 µg/mL Concanavalin A in cRPMI for 3 days, washed and resuspended in culture media with 20 U/mL IL-2.
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PMC11779605
A, B) Predictive value of tumor FGF7 protein expression.
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PMC9325715
Thus, nearly 1.5 mg of the complex was mineralized with 0.1 mL of MS-Grade nitric acid.
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PMC10899471
Mammalian BATF2 overexpression plasmids (pBATF2) and empty plasmid vector pcDNA3.1 (pControl) were purchased from Tsingke Biotechnology for transfection into HT-1080 cells by using Lipofectamine 3000 (Invitrogen).
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