OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC8806312	Figure 3(a) shows a forest plot of hazard ratios (Fp/HR), illustrating the associations between 9 survival-related IRGs and the overall survival rate in OS patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11785489	We used the Adam optimizer and the binary cross-entropy with logits loss function (“BCEWithLogitsLoss” from python package torch), and iterated over a grid of hyperparameters corresponding to batch size, learning rate, and size of hidden layers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7189327	PPI network analysis was conducted to explore the underlying interactions of DEGs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PPI", "network", "analysis", "was", "conducted", "to", "explore", "the", "underl...
PMC11387401	Positive and negative correlations are depicted in blue and red, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Positive", "and", "negative", "correlations", "are", "depicted", "in", "blue", "...
PMC11627133	Visualization of EGFR in fixed A431 cells stained with J18‐RhoBAST (500 nM) and SpyRho (1 nM).	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Visualization", "of", ...
PMC11699178	As reported in the literature, GEM has been shown to inhibit the proliferation, invasion, and metastasis of ovarian cancer cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", ...
PMC7053076	U-332 can be viewed as an important lead compound in the search for novel drug candidates that would not cause multidrug resistance in cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10055960	Complex 8 shows the greatest cytotoxicity of the metallodendrimers in the A2780 and OVCAR-3 cell lines with IC50 values of 64.82 and 69.05, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11365427	In response to the challenges of cancer treatment, the development of drugs targeting metabolic remodeling has advanced from preclinical to clinical research based on many studies, showing promising therapeutic efficacy13, 14, 15.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Image: Summary/Conclusion: This real-world, post-approval study reconfirms that first-line treatment of CD20-positive DLBCL with R-CHOP using SDZ-RTX is effective over a 24-month observation period, with no unexpected safety signals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11640555	The densitometric values obtained are normalized to β-actin and expressed as % of the control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "densitometric", "values", "obtained", "are", "normalized",...
PMC10222971	Naphthoquinones are a valuable source of secondary metabolites that are well known for their dye properties since ancient times.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Naphthoquinones", "are", "a", "va...
PMC11707577	Figure S12 (Supporting Information) shows the intact Hydra epithelium observed at all conditions, indicating the absence of effects from the generic fluorophore, and confirming the specific cell ablation observed, upon irradiation, with M13EGFR(TNP).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594588	Platelets are the smallest non-nucleated (anucleate) blood cells that contain typical cellular organelles, including mitochondria, which enable them to exhibit an active metabolism .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8633974	Cells were adequately washed with 1x PBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "adequately", "washed", "with", "1x", "PBS", "." ] } ]
PMC11347429	Several samples were analyzed in multiple batches, these duplicates were removed and a unique sample dataset was generated ( Data file 3 for description of the samples).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	However, the trend towards a decrease in the number of CD34+ cells circulating in the peripheral blood on the day of the first session of leukacytapheresis with the use of less intensive schemes (G-CSF, vinorelbine with G-CSF) gives reason to take into account the status of MRD when choosing a mobilization regimen.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9341513	Nevertheless, the predictions are largely consistent with the qPCR data, even if this is not a direct validation of the predicted structures (see Supplemental Methods and Supplemental Fig. S3Ei for further details).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10454535	Following the 24 h treatment, the cells were isolated, washed in PBS, and then resuspended in 1 mL of binding buffer from the FITC Annexin V Apoptosis Detection Kit (BD Biosciences).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5311252	Finally, as miR-372-3p expression was undetectable in all parental cells and GFP-control cells, miR-372-3p expression in the four NSCLC cell lines was reported in relation to the endogenous expression of miR-372-3p in 833KE cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: This study was approved by the Institutional Review Board of Peking Union Medical College Hospital and registered (NCT04217967).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":...
PMC11429241	In conclusion, cell growth and proliferation were not affected by the scaffold material or shape.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "conclusion", ",", "cell", "growth", "and", ...
PMC11739670	Expression cassettes were cloned in‐frame with C‐terminal Avi‐tag and His6 tag in pCDNA3.1 encoding an additional BirA Ligase.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Expression", "cassettes", "were", "cloned", ...
PMC8584319	In contrast, p38s and JNKs, also known as stress-activated protein kinases, mainly activate inflammatory and stress responses .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",", ...
PMC9429973	The search was performed using MEDLINE, Embase and the Cochrane Library from database inception to July 2021.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "search", "was", "performed", "u...
PMC9429973	MRD negativity by 6-color flow cytometry was achieved in 32/42 evaluable pts (76%) after 1 cycle and 55/58 evaluable pts (95%) overall.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6442998	In GIST48 cells, lower PDE3A expression and stronger activation of KIT downstream pathways (i.e. resistance to imatinib) overcomes the effect of cilostazol on YAP-driven viability.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11367146	In the 100 ns of simulation trajectory, ESR1, ESR1-daucosterol and ESR1-gigantol showed a comparable trajectory with a stabilized Rg in the range of 1.82–1.84 nm (Fig. 6E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11552389	Scratch wound healing assays were used to evaluate migratory potential after transfection of A375 cells with FOXN3 expression vectors or transfection of A875 cells with shR1. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "...
PMC11787651	B, correlation heatmap of all replicates of control, M344, and entinostat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", ",", "correlation", "heatmap", "of", "all", "replicates", "o...
PMC10631132	Additionally, mononuclear cells with varying degrees of Cathepsin K expression were interspersed with the large multinucleated cells (empty arrows in Fig. 5A and E).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Over the entire follow-up, 24p. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Over", "the", "entire", "follow-up", ",", "24p", ".", "(" ] } ]
PMC11643491	Therefore, films containing embedded spherical PS particles were marked with square grid lines (Figure 1A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "films", "containing", ...
PMC11705862	Besides neuronal expression, we also found an expression of IRIS-1 and 2 in astrocytes, but very little or none in microglia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Besides...
PMC11429241	Here, we have to note that degradation of the scaffolds was not evaluated, as for both OrmoClear and PEGDA, it should not occur for such a short 7-day study .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: We retrospectively described the clinical, biological, and genomic characteristics of a series of 36 LCH patients with thyroid involvement in our centre between January 2001 and December 2021.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3035438	O.D. values were corrected with the medium background value.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "O.D.", "values", "were", "corrected", "with", "the", "medium", "background", "value", "." ] } ]
PMC9581083	tinctoria, Oldenlandia herbacea (L.) Roxb.,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "tinctoria", ",", "Oldenlandia", "herbacea", "(", "L.", ")", "Roxb", ".", "," ] } ]
PMC11473750	The secondary structures with the light and darker blue colours are predicted with the most confidence, whereas the yellow and red colours signify the least confident predictions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11637276	Primary antibody against phospho-p38 MAPK (Rabbit PolyAb Thr180/Tyr182) from Proteintech (28796-1-AP).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Primary", "antibody", "against", "phospho-p38", "...
PMC9429973	Their ferritin levels at time of referral was 1500 ng/ml and 1220 ng/ml respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Their", "ferritin", "levels", "at", "time", "of", "referral", "w...
PMC4659567	These results are consistent with a detection of various adducts with GSH in the ESI+ mass spectra of the studied complexes dissolved in 10% MeOH/H2O.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC6379402	Cell viability is calculated relative to the corresponding esiLuciferase controls (set to 100%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "viability", "is", "calculated", "relative", "t...
PMC11541409	However, a small portion of GIST cells enter a cell-cycle-arrested state, exhibiting quiescent-like, senescence-like, and stem-cell-like characteristics that make them resistant to cell death, and capable of repopulation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11795610	p < 0.05, p < 0.01, and *p < 0.001 versus NOR group; p < 0.01 and p < 0.001 versus High Ca group; ns1 indicated no significant difference as compared to the NOR group; ns indicated no statistically difference as compared to the High Ca group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10747160	We wished to ascertain whether the additional SARS-CoV-2 structural proteins M, N, and E could be responsible for the apparent increased susceptibility of the coronaviral virions to Wild-Type Griffithsin-based inhibition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6600253	Many studies have shown that PT exhibits high bioavailability and a high potential for cellular uptake.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Many", "studies", "have", "shown", "that", "PT", ...
PMC11087301	Epithelial-to-mesenchymal transition of tumor cells includes acquisition of specific features to stay viable when detach from the primary tissue and circulate in the bloodstream.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11544122	a CXCR4 endocytosis was examined in parental HeLa cells or HeLa cells deleted of β-arrestin1 (β-arr1 KO), β-arrestin2 (β-arr2 KO), or both β-arr1 and β-arr2 (β-arr1/2 DKO).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11119602	Only following the subcellular isolation of lysates obtained from parental and chemoresistant cells, did it become apparent that it was not the differential expression of TG2 isoforms that was responsible for the development of cisplatin chemoresistance but it was, in fact, the differential localisation of TG2 isoforms...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10887351	However, β3-ARs’ role in humans is somehow controversial due to the late discovery, the lack of selective detection instruments and the inter-species differences.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11705862	Noradrenaline secretion from SH-SY5Y cells with or without CD59, IRIS-1, and 2 knockdown.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Noradrenaline", "secretion", "from", "SH-SY5Y", "cells", ...
PMC6222726	It belongs to the fagaroides group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "belongs", "to", "the", "fagaroides", "group", "." ] } ]
PMC11745600	The smaller size of mice constitutes a significant advantage (particularly in cell transplantation experiments) because the number of transplanted cells can be reduced, which allows for a cost-effective assessment of the efficacy and safety of transplanted cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10568263	After loading HSP70 on the BSA/antiHSP70/EN-LC/Au@MnO2/MoO3/SPE surface, the Rct-value was increased to 4.47 kΩ due to the formation of an antibody (anti-HSP70)-antigen (HSP70) complex layer on the electrode that hindered the transfer of electrons.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11240052	p< 0.001.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.001", "." ] } ]
PMC9429973	In all studies to date, EFG was well tolerated, and adverse events were mainly mild to moderate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "all", "studies", "to", ...
PMC11345828	The reaction was sealed and heated to 100 °C for 18 h. The reaction was cooled to room temperature and diluted with 1:1 EtOAc/H2O.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10213179	At the endpoint of the experiment, mice were euthanized, lungs were harvested, and an ex vivo IVIS reading was performed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", ...
PMC11522251	Additionally, we detected and compared the three cells’ expressions of p-STAT3 and HOXB8.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "we", "detected", "and", "compared", "t...
PMC11271800	The efficacy of imatinib as a TKI depends on the exons involved in KIT and PDGFRA mutations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "efficacy", "of", "imatinib", "as", "...
PMC11754436	A short hairpin RNA (shRNA/sh) sequence specific for human DHRS4-AS1 and the negative sequence were purchased from GeneChem Co., Ltd (Shanghai, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Median disease duration was 4.1 y (range, 0–56.3), 456 (20.1%) had TE history; 52.6% of pts received hydroxyurea.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11345828	H NMR (CDCl3) δ 7.71 (d, J = 8.8 Hz, 1H), 7.28 (d, J = 8.4 Hz, 1H), 6.63 (s, 2H), 5.74 (d, J = 5.2 Hz, 1H), 4.00 (td, J = 6.4, 1.6 Hz, 2H), 3.75–3.69 (m, 2H), 3.42–3.30 (m, 2H), 3.15 (dd, J = 11.2, 5.6 Hz, 1H), 2.79 (s, 3H), 2.33 (s, 9H), 2.19 (quint, J = 7.2 Hz, 2H), 2.14 (s, 3H), 1.02 (d, J = 6.8 Hz, 3H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11334037	The downstream molecular pathways of the KIT mutation include PI3K/AKT, JAK-STAT, Src family kinases, and Ras-ERK).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "downstream", "molecul...
PMC6379402	We used two initial solution generators.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "used", "two", "initial", "solution", "generators", "." ] } ]
PMC7334607	Overview of Experimental Evolution of Resistance in Ewing’s Sarcoma Cell Lines As cells recovered from each exposure, cells were tested for their sensitivity to a panel of drugs and samples were frozen for potential use in RNA sequencing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	We will present updated and detailed PK, cytokine, and CAR-T subset analyses as well as clinical correlation to provide novel insights into biological correlates of efficacy and safety in this difficult-to-treat patient population, which is being further evaluated in the CARTITUDE-4 study (NCT04181827; enrollment concl...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The lack of seasonal variability in this cohort suggests that treatment considerations for patients with CAD should be season-independent.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "lack", "of", "seasonal", ...
PMC11799620	The cells were incubated at 37°C in a CO2 incubator in an atmosphere of humidified 5% CO2 in 95% air.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Methods: This retrospective study included all CBF-AML diagnosed between 2002 and 2020 in the hematology department of the University Hospital of Sousse.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods...
PMC9429973	Patients suitable for allogeneic HSCT at the time of screening, or who received prior treatment for MDS with any HMA, chemotherapy or allogeneic HSCT are excluded.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	These results add to the evolving data demonstrating potential real-world benefits of mitapivat for patients with PK deficiency and supports mitapivat as an effective and disease-modifying therapy for this condition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3164356	CHO-derived immortalized cell lines are the preferred host system for therapeutic protein production.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CHO-derived", "immortalized", "cell", "lines", "are", "the", "preferred"...
PMC11789597	The Proteome Profiler Human XL Cytokine Array Kit (R&D Systems, Minnesota, USA) was used based on the manufacturer's instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	For inclusion in the study, patients either had to have demonstrable “pathognomonic” clinic-morphological features of splenomegaly, bone marrow and/ or peripheral blood hyperleukocytosis, and bi-modal peak of mature neutrophils with myelocytes, or presence of leucoerythroblastic picture with myeloproliferative features...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11607638	Compared with controls, no significant difference was found in the blood intake of female mosquitoes injected with 50 μM SK2, while blood intake after injection with 100 and 150 μM SK2 was significantly reduced (data with SK2 at 200 μM in panel C replotted in panel E) (right, Figure 3E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10490530	On the other hand, the NF-κB complex is also known to bind to the p300/CBP to carry out its transcriptional activity .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "the", ...
PMC9429973	Regarding the Treg cells, although all lymphoma patients exhibited increased absolute numbers of CD4CD25CD127 Treg cells, Foxp3-expressing Tregs were significantly increased in the PB of DLBCL and MZL patients, but not in FL patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10362265	Human AF: blue, human model: black, human crystal: red, 3f62: green, 4ekx: orange, 4eee-SS AB chains: purple, 4eee-SS CD chains: yellow, 4eee-SH AB chains: teal, 4eee-SH CD chains: pink.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11659734	The model was established and validated in both laboratories, confirming its transferability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "model", "was", "established", "and", "validated", "in", "both", ...
PMC11365983	These structural changes were associated with substantially perturbed cilia-dependent signaling [Hedgehog (Hh) and PDGFRα], and altered ciliary compartmentalization of the Hh pathway transcription factor, Gli2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11269933	Significant differences among groups were marked with p < 0.05, p < 0.01, p < 0.001, and p < 0.0001. “	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11474209	It is cheaper, making it more attractive.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "cheaper", ",", "making", "it", "more", "attractive", "." ] } ]
PMC11637276	Scale bar, 200 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ",", "200", "μm", "." ] } ]
PMC11482552	This could mean that an undetected infection or early-stage precancerous lesions could progress into more advanced disease, potentially resulting in cervical cancer due to untimely follow-up care.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11486946	The 18 hit compounds include all EGFR-targeted tyrosine kinase inhibitors (TKIs) in the library that suppress any phosphorylation-dependent mobility shift of EGFR, proving the concept of this approach.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10073922	Annexin V/7AAD flow cytometry was used to evaluate the effect of NDRG2 overexpression on cell apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Annexin", "V/7AAD", "flow", "cytometry", "was", "used"...
PMC11075223	Actein (0.1, 1 μM) induced the differentiation of MC3T3-E1 cells by promoting collagen content, alkaline phosphatase (ALP) activity, osteocalcin release and calcium deposition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	A second part was gender-specific, with questions on gamete cryopreservation habits, percentage of successful procedures and age limits for cryopreservation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "second"...
PMC9429973	Tagraxofusp (TAG), a first-in-class CD123-targeted therapy, was approved by the European Medicines Agency in 2021 for treatment of BPDCN in first-line adult pts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11066331	Plot documenting PLS-DA classification outputs for the validation dataset (D).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Plot", "documenting", "PLS-DA", "classification", "outputs", "for", "the", "validation", "dataset", ...
PMC9429973	Finally, molecular pathways altered were analysed by western blot or qPCR in DoHH2 treated with butyrate 1mM. Results: Responder patients exhibited higher microbial richness, equity and α-diversity indexes than non-responder´s ones (Fig 1A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11092382	Sophocarpine-induced the nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3 (NLRP3) degradation by autophagy may be responsible for its protective effects (Hou et al., 2020).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2944824	Similarly, levels of Bax, which is regulated by p53, were also lower in cell expressing Hr (figure 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similar...
PMC9429973	DREIMT apply a drug prioritization score (T, tau, ranging +100 to -100) following the approach described by LINCS L1000 team.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Results: Detailed data of immune populations of FL patients and healthy controls is shown in the table.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "Detailed", "data", "of...
PMC9429973	Aims: This study aimed to describe treatment persistence and adherence to ibrutinib in German patients with WM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "This", "study", "aimed", ...
PMC9429973	PFS and OS are similar to those of other transplant centers at home or abroad.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PFS", "and", "OS", "are", "similar", "to", "those", "...
PMC10820104	However, a slight increase in the sub-G1 peak was observed after treatment with compounds 1 and 4, but this did not reach levels of statistical significance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8806312

Figure 3(a) shows a forest plot of hazard ratios (Fp/HR), illustrating the associations between 9 survival-related IRGs and the overall survival rate in OS patients.

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PMC11785489

We used the Adam optimizer and the binary cross-entropy with logits loss function (“BCEWithLogitsLoss” from python package torch), and iterated over a grid of hyperparameters corresponding to batch size, learning rate, and size of hidden layers.

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PMC7189327

PPI network analysis was conducted to explore the underlying interactions of DEGs.

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PMC11387401

Positive and negative correlations are depicted in blue and red, respectively.

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PMC11627133

Visualization of EGFR in fixed A431 cells stained with J18‐RhoBAST (500 nM) and SpyRho (1 nM).

[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Visualization", "of", ...

PMC11699178

As reported in the literature, GEM has been shown to inhibit the proliferation, invasion, and metastasis of ovarian cancer cells .

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PMC7053076

U-332 can be viewed as an important lead compound in the search for novel drug candidates that would not cause multidrug resistance in cancer cells.

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PMC10055960

Complex 8 shows the greatest cytotoxicity of the metallodendrimers in the A2780 and OVCAR-3 cell lines with IC50 values of 64.82 and 69.05, respectively.

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PMC11365427

In response to the challenges of cancer treatment, the development of drugs targeting metabolic remodeling has advanced from preclinical to clinical research based on many studies, showing promising therapeutic efficacy13, 14, 15.

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PMC9429973

Image: Summary/Conclusion: This real-world, post-approval study reconfirms that first-line treatment of CD20-positive DLBCL with R-CHOP using SDZ-RTX is effective over a 24-month observation period, with no unexpected safety signals.

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PMC11640555

The densitometric values obtained are normalized to β-actin and expressed as % of the control.

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PMC10222971

Naphthoquinones are a valuable source of secondary metabolites that are well known for their dye properties since ancient times.

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PMC11707577

Figure S12 (Supporting Information) shows the intact Hydra epithelium observed at all conditions, indicating the absence of effects from the generic fluorophore, and confirming the specific cell ablation observed, upon irradiation, with M13EGFR(TNP).

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PMC11594588

Platelets are the smallest non-nucleated (anucleate) blood cells that contain typical cellular organelles, including mitochondria, which enable them to exhibit an active metabolism .

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PMC8633974

Cells were adequately washed with 1x PBS.

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PMC11347429

Several samples were analyzed in multiple batches, these duplicates were removed and a unique sample dataset was generated ( Data file 3 for description of the samples).

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PMC9429973

However, the trend towards a decrease in the number of CD34+ cells circulating in the peripheral blood on the day of the first session of leukacytapheresis with the use of less intensive schemes (G-CSF, vinorelbine with G-CSF) gives reason to take into account the status of MRD when choosing a mobilization regimen.

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PMC9341513

Nevertheless, the predictions are largely consistent with the qPCR data, even if this is not a direct validation of the predicted structures (see Supplemental Methods and Supplemental Fig. S3Ei for further details).

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PMC10454535

Following the 24 h treatment, the cells were isolated, washed in PBS, and then resuspended in 1 mL of binding buffer from the FITC Annexin V Apoptosis Detection Kit (BD Biosciences).

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PMC5311252

Finally, as miR-372-3p expression was undetectable in all parental cells and GFP-control cells, miR-372-3p expression in the four NSCLC cell lines was reported in relation to the endogenous expression of miR-372-3p in 833KE cells.

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PMC9429973

Methods: This study was approved by the Institutional Review Board of Peking Union Medical College Hospital and registered (NCT04217967).

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PMC11429241

In conclusion, cell growth and proliferation were not affected by the scaffold material or shape.

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PMC11739670

Expression cassettes were cloned in‐frame with C‐terminal Avi‐tag and His6 tag in pCDNA3.1 encoding an additional BirA Ligase.

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PMC8584319

In contrast, p38s and JNKs, also known as stress-activated protein kinases, mainly activate inflammatory and stress responses .

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PMC9429973

The search was performed using MEDLINE, Embase and the Cochrane Library from database inception to July 2021.

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PMC9429973

MRD negativity by 6-color flow cytometry was achieved in 32/42 evaluable pts (76%) after 1 cycle and 55/58 evaluable pts (95%) overall.

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PMC6442998

In GIST48 cells, lower PDE3A expression and stronger activation of KIT downstream pathways (i.e. resistance to imatinib) overcomes the effect of cilostazol on YAP-driven viability.

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PMC11367146

In the 100 ns of simulation trajectory, ESR1, ESR1-daucosterol and ESR1-gigantol showed a comparable trajectory with a stabilized Rg in the range of 1.82–1.84 nm (Fig. 6E).

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PMC11552389

Scratch wound healing assays were used to evaluate migratory potential after transfection of A375 cells with FOXN3 expression vectors or transfection of A875 cells with shR1. (

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PMC11787651

B, correlation heatmap of all replicates of control, M344, and entinostat.

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PMC10631132

Additionally, mononuclear cells with varying degrees of Cathepsin K expression were interspersed with the large multinucleated cells (empty arrows in Fig. 5A and E).Fig.

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PMC9429973

Over the entire follow-up, 24p. (

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PMC11643491

Therefore, films containing embedded spherical PS particles were marked with square grid lines (Figure 1A).

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PMC11705862

Besides neuronal expression, we also found an expression of IRIS-1 and 2 in astrocytes, but very little or none in microglia.

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PMC11429241

Here, we have to note that degradation of the scaffolds was not evaluated, as for both OrmoClear and PEGDA, it should not occur for such a short 7-day study .

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PMC9429973

Methods: We retrospectively described the clinical, biological, and genomic characteristics of a series of 36 LCH patients with thyroid involvement in our centre between January 2001 and December 2021.

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PMC3035438

O.D. values were corrected with the medium background value.

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PMC9581083

tinctoria, Oldenlandia herbacea (L.) Roxb.,

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PMC11473750

The secondary structures with the light and darker blue colours are predicted with the most confidence, whereas the yellow and red colours signify the least confident predictions.

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PMC11637276

Primary antibody against phospho-p38 MAPK (Rabbit PolyAb Thr180/Tyr182) from Proteintech (28796-1-AP).

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PMC9429973

Their ferritin levels at time of referral was 1500 ng/ml and 1220 ng/ml respectively.

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PMC4659567

These results are consistent with a detection of various adducts with GSH in the ESI+ mass spectra of the studied complexes dissolved in 10% MeOH/H2O.

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PMC6379402

Cell viability is calculated relative to the corresponding esiLuciferase controls (set to 100%).

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PMC11541409

However, a small portion of GIST cells enter a cell-cycle-arrested state, exhibiting quiescent-like, senescence-like, and stem-cell-like characteristics that make them resistant to cell death, and capable of repopulation .

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PMC11795610

p < 0.05, **p < 0.01, and ***p < 0.001 versus NOR group; p < 0.01 and p < 0.001 versus High Ca group; ns1 indicated no significant difference as compared to the NOR group; ns indicated no statistically difference as compared to the High Ca group.

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PMC10747160

We wished to ascertain whether the additional SARS-CoV-2 structural proteins M, N, and E could be responsible for the apparent increased susceptibility of the coronaviral virions to Wild-Type Griffithsin-based inhibition.

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PMC6600253

Many studies have shown that PT exhibits high bioavailability and a high potential for cellular uptake.

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PMC11087301

Epithelial-to-mesenchymal transition of tumor cells includes acquisition of specific features to stay viable when detach from the primary tissue and circulate in the bloodstream.

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PMC11544122

a CXCR4 endocytosis was examined in parental HeLa cells or HeLa cells deleted of β-arrestin1 (β-arr1 KO), β-arrestin2 (β-arr2 KO), or both β-arr1 and β-arr2 (β-arr1/2 DKO).

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PMC11119602

Only following the subcellular isolation of lysates obtained from parental and chemoresistant cells, did it become apparent that it was not the differential expression of TG2 isoforms that was responsible for the development of cisplatin chemoresistance but it was, in fact, the differential localisation of TG2 isoforms...

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PMC10887351

However, β3-ARs’ role in humans is somehow controversial due to the late discovery, the lack of selective detection instruments and the inter-species differences.

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PMC11705862

Noradrenaline secretion from SH-SY5Y cells with or without CD59, IRIS-1, and 2 knockdown.

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PMC6222726

It belongs to the fagaroides group.

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PMC11745600

The smaller size of mice constitutes a significant advantage (particularly in cell transplantation experiments) because the number of transplanted cells can be reduced, which allows for a cost-effective assessment of the efficacy and safety of transplanted cells.

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PMC10568263

After loading HSP70 on the BSA/antiHSP70/EN-LC/Au@MnO2/MoO3/SPE surface, the Rct-value was increased to 4.47 kΩ due to the formation of an antibody (anti-HSP70)-antigen (HSP70) complex layer on the electrode that hindered the transfer of electrons.

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PMC11240052

p< 0.001.

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PMC9429973

In all studies to date, EFG was well tolerated, and adverse events were mainly mild to moderate.

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PMC11345828

The reaction was sealed and heated to 100 °C for 18 h. The reaction was cooled to room temperature and diluted with 1:1 EtOAc/H2O.

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PMC10213179

At the endpoint of the experiment, mice were euthanized, lungs were harvested, and an ex vivo IVIS reading was performed.

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PMC11522251

Additionally, we detected and compared the three cells’ expressions of p-STAT3 and HOXB8.

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PMC11271800

The efficacy of imatinib as a TKI depends on the exons involved in KIT and PDGFRA mutations.

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PMC11754436

A short hairpin RNA (shRNA/sh) sequence specific for human DHRS4-AS1 and the negative sequence were purchased from GeneChem Co., Ltd (Shanghai, China).

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PMC9429973

Median disease duration was 4.1 y (range, 0–56.3), 456 (20.1%) had TE history; 52.6% of pts received hydroxyurea.

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PMC11345828

H NMR (CDCl3) δ 7.71 (d, J = 8.8 Hz, 1H), 7.28 (d, J = 8.4 Hz, 1H), 6.63 (s, 2H), 5.74 (d, J = 5.2 Hz, 1H), 4.00 (td, J = 6.4, 1.6 Hz, 2H), 3.75–3.69 (m, 2H), 3.42–3.30 (m, 2H), 3.15 (dd, J = 11.2, 5.6 Hz, 1H), 2.79 (s, 3H), 2.33 (s, 9H), 2.19 (quint, J = 7.2 Hz, 2H), 2.14 (s, 3H), 1.02 (d, J = 6.8 Hz, 3H).

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PMC11334037

The downstream molecular pathways of the KIT mutation include PI3K/AKT, JAK-STAT, Src family kinases, and Ras-ERK).

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PMC6379402

We used two initial solution generators.

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PMC7334607

Overview of Experimental Evolution of Resistance in Ewing’s Sarcoma Cell Lines As cells recovered from each exposure, cells were tested for their sensitivity to a panel of drugs and samples were frozen for potential use in RNA sequencing.

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PMC9429973

We will present updated and detailed PK, cytokine, and CAR-T subset analyses as well as clinical correlation to provide novel insights into biological correlates of efficacy and safety in this difficult-to-treat patient population, which is being further evaluated in the CARTITUDE-4 study (NCT04181827; enrollment concl...

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PMC9429973

The lack of seasonal variability in this cohort suggests that treatment considerations for patients with CAD should be season-independent.

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PMC11799620

The cells were incubated at 37°C in a CO2 incubator in an atmosphere of humidified 5% CO2 in 95% air.

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PMC9429973

Methods: This retrospective study included all CBF-AML diagnosed between 2002 and 2020 in the hematology department of the University Hospital of Sousse.

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PMC9429973

Patients suitable for allogeneic HSCT at the time of screening, or who received prior treatment for MDS with any HMA, chemotherapy or allogeneic HSCT are excluded.

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PMC9429973

These results add to the evolving data demonstrating potential real-world benefits of mitapivat for patients with PK deficiency and supports mitapivat as an effective and disease-modifying therapy for this condition.

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PMC3164356

CHO-derived immortalized cell lines are the preferred host system for therapeutic protein production.

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PMC11789597

The Proteome Profiler Human XL Cytokine Array Kit (R&D Systems, Minnesota, USA) was used based on the manufacturer's instructions.

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PMC9429973

For inclusion in the study, patients either had to have demonstrable “pathognomonic” clinic-morphological features of splenomegaly, bone marrow and/ or peripheral blood hyperleukocytosis, and bi-modal peak of mature neutrophils with myelocytes, or presence of leucoerythroblastic picture with myeloproliferative features...

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PMC11607638

Compared with controls, no significant difference was found in the blood intake of female mosquitoes injected with 50 μM SK2, while blood intake after injection with 100 and 150 μM SK2 was significantly reduced (data with SK2 at 200 μM in panel C replotted in panel E) (right, Figure 3E).

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PMC10490530

On the other hand, the NF-κB complex is also known to bind to the p300/CBP to carry out its transcriptional activity .

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PMC9429973

Regarding the Treg cells, although all lymphoma patients exhibited increased absolute numbers of CD4CD25CD127 Treg cells, Foxp3-expressing Tregs were significantly increased in the PB of DLBCL and MZL patients, but not in FL patients.

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PMC10362265

Human AF: blue, human model: black, human crystal: red, 3f62: green, 4ekx: orange, 4eee-SS AB chains: purple, 4eee-SS CD chains: yellow, 4eee-SH AB chains: teal, 4eee-SH CD chains: pink.

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PMC11659734

The model was established and validated in both laboratories, confirming its transferability.

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PMC11365983

These structural changes were associated with substantially perturbed cilia-dependent signaling [Hedgehog (Hh) and PDGFRα], and altered ciliary compartmentalization of the Hh pathway transcription factor, Gli2.

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PMC11269933

Significant differences among groups were marked with p < 0.05, p < 0.01, p < 0.001, and p < 0.0001. “

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PMC11474209

It is cheaper, making it more attractive.

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PMC11637276

Scale bar, 200 μm.

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PMC11482552

This could mean that an undetected infection or early-stage precancerous lesions could progress into more advanced disease, potentially resulting in cervical cancer due to untimely follow-up care.

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PMC11486946

The 18 hit compounds include all EGFR-targeted tyrosine kinase inhibitors (TKIs) in the library that suppress any phosphorylation-dependent mobility shift of EGFR, proving the concept of this approach.

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PMC10073922

Annexin V/7AAD flow cytometry was used to evaluate the effect of NDRG2 overexpression on cell apoptosis.

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PMC11075223

Actein (0.1, 1 μM) induced the differentiation of MC3T3-E1 cells by promoting collagen content, alkaline phosphatase (ALP) activity, osteocalcin release and calcium deposition.

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PMC9429973

A second part was gender-specific, with questions on gamete cryopreservation habits, percentage of successful procedures and age limits for cryopreservation.

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PMC9429973

Tagraxofusp (TAG), a first-in-class CD123-targeted therapy, was approved by the European Medicines Agency in 2021 for treatment of BPDCN in first-line adult pts.

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PMC11066331

Plot documenting PLS-DA classification outputs for the validation dataset (D).Fig.

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PMC9429973

Finally, molecular pathways altered were analysed by western blot or qPCR in DoHH2 treated with butyrate 1mM. Results: Responder patients exhibited higher microbial richness, equity and α-diversity indexes than non-responder´s ones (Fig 1A).

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PMC11092382

Sophocarpine-induced the nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3 (NLRP3) degradation by autophagy may be responsible for its protective effects (Hou et al., 2020).

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PMC2944824

Similarly, levels of Bax, which is regulated by p53, were also lower in cell expressing Hr (figure 4).

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PMC9429973

DREIMT apply a drug prioritization score (T, tau, ranging +100 to -100) following the approach described by LINCS L1000 team.

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PMC9429973

Results: Detailed data of immune populations of FL patients and healthy controls is shown in the table.

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PMC9429973

Aims: This study aimed to describe treatment persistence and adherence to ibrutinib in German patients with WM.

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PMC9429973

PFS and OS are similar to those of other transplant centers at home or abroad.

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PMC10820104

However, a slight increase in the sub-G1 peak was observed after treatment with compounds 1 and 4, but this did not reach levels of statistical significance.

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