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OTAR3088
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BioData-CellLine_annotated

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PMC11686380
Rabbit polyclonal anti-GAP43 was purchased from Abcam (Cambridge UK).
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PMC8956657
A cartoon representation is shown below highlighting the hydrogen bonds and salt bridges (in bold).
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PMC7022782
All these results suggested that ICG-loaded NPs could be proposed as theranostic agents for tumor diagnosis and treatment.
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PMC10551595
The CI value was calculated according to the following formula: CI=Dxcom1Dx1+Dxcom2Dx2 where (Dx)com1 or (Dx)com2 is the drug concentration in the combination treatment that inhibited % viability, and (Dx)1 or (Dx)2 was the drug concentration alone that caused the same percentage inhibition.
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PMC9429973
Pts received a median of 3 prior therapies (range 2-8), and all had relapsed on their last therapy.
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PMC11098378
Interestingly, cells expressing either SHOC2 sgRNA-A or sgRNA-B were significantly more susceptible to infection with ONNV-GFP, SINV-GFP, and VSV-GFP infection (Fig 6A).
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PMC11742290
Massive tumor tissue necrosis and growth inhibition were observedRSPO1-DoxorubicinCRC cell lines: LOVO and RAW264.7Female BALB/c nude mice.
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PMC11224020
These data strongly suggest that cPLA2 acts upstream of IKKβ and NF-κB to trigger upregulation of CCR7 expression after shape sensing in DCs.
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PMC10938336
Apoptosis testing showed that compounds 2 and 4 were effective against the HL-60 cell line after 24 h treatment.
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PMC11637276
Primary antibody against p38 MAPK from Cell signalling (9212S).
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PMC8701144
The HEK293 cell line was originally established by transfection with sheared adenoviral DNA, and it has been shown that these cells express the adenoviral E1A and E1B proteins .
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PMC11600602
We read with great interest the proposal of Philipp-Dormston et al. (1) to abandon the outdated, ill-defined umbrella designation “non-melanoma skin cancer” (NMSC) in favour of “keratinocyte cancer” (KC), a “more precise and reasonable terminology, valuing the relevance of keratinocyte-derived cancer”.
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PMC11127909
G Flow cytometric analysis of apoptosis in 143B and MG63 cells after cisplatin treatment for 2 days, N = 3.
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PMC10507284
Additionally, we further confirmed the relevance between TROAP and the prognosis of STS using an external validation set.
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PMC10344560
Rhodotorula sp. infections could occur at any site of the body, and Rhodotorula glutinis was never reported as an etiology of onychomycosis.
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PMC11546117
Importantly, other factors, such as the unbound fraction as well as the degree of ionization in plasma and milk have been demonstrated to influence this M/P ratio .
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PMC11457557
The Canagliflozin and Renal Events in DM with Established Nephropathy Clinical Evaluation (CREDENCE) study showed that SGLT2 inhibitors stopped DKD from progressing .
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PMC11476837
We believed that the obtained results were a prerequisite for further studies on NRF2 inhibition as an approach for abolishing doxorubicin resistance in promyelocytic leukemia cells.
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PMC11281366
In some cases, primary CD4 T cells were pre-treated with efavirenz (EFV, 10 μM, Sigma-Aldrich, St. Louis, MO, USA, #SML0536) or raltegravir (RAL, 20 μM, Santa Cruz Biotechnology, Dallas, TX, USA, #sc-364600) overnight and replenished in new media accordingly during the infection.
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PMC11718817
Pharmacological inhibition of NLRP3 with small molecule MCC950 reduced PD-L1 expression .
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PMC8358006
As expected, we found that the set of 5% broadest H3K27me3 domains was enriched in oncogenes in NE2 cells (Supplementary Fig. 2).
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PMC11470999
Data are presented as mean ± standard deviation or standard error of the mean.
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PMC10999934
FBXO2 could impact chemoresistance by influencing the PI3K-Akt signaling pathway, focal adhesion, and ECM-receptor interactions and regulating tumorigenesis.
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PMC11721295
Manufacturer details for antibodies are listed in Supplemental Table 1.
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PMC9792775
Data are shown as the mean ± SD. *
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PMC11583010
The final H-score ranged from 0 to 300 for cancer cells.
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PMC11593084
We then examined whether PMab-117-mG2a possesses ADCC activity against PDPN-positive cells.
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PMC11307990
Scale bars: 300 nm. (
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PMC11401358
High levels of ROS existed in cells along the edge of the amputated fin, and the ROS were immediately eliminated upon SF treatment for 30 min (Fig. 3G and H).
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PMC10698968
Specifically, the sample was treated with 2 mg/ml collagenase type I-A (Sigma-Aldrich, Merck Group) in D-PBS with Ca Mg (Life-Technologies) for 2 hours at 37°C in a humidified incubator.
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PMC11777207
There were also similar amounts of cDC1s that expressed slightly higher amounts of CD80 within αPD-L1 43H12 mice compared to IgG mice after IMQ treatment but fewer cDC1s in Pdl1 mice (fig. S9).
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PMC11738017
As predicted, sBCMA did not interfere with the cytotoxic activity of talquetamab, a TCE that targets an alternative antigen, GPRC5D (Figure 3C).
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PMC9398137
We observed that the SU-DHL-5 and UPF4D cells were less sensitive to S63845 as compared with the corresponding parental cell lines (Fig. 2A).
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PMC11297139
The DEGs were obtained using DESeq2 with a false discovery rate (FDR) < 0.05.
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PMC11588085
The statistical analyses were performed with a two-tailed ANOVA test. (
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PMC11766174
The binding domain of the ZeptoMetrix anti-HIV CA mAb is located within the p24 amino acid position 46–75 (GATPQDLNTMLNTVGGHQAAMQMLKETINE), as determined by mass spectrometry.
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PMC10858941
Thus, a potential overactivation of the proteasome by NNC may be consequence of the defective autophagy .
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PMC9504875
The cells were mock-infected or infected with SeV for 24 h, and were then lysed with lysis buffer containing 50 mM Tris-HCl (pH7.4), 50 mM NaCl, 0.6% NP-40, and cOmplete proteinase inhibitor cocktail.
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PMC11300085
It is unclear that how chemerin regulates biological behaviors of OC cells.
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PMC11401358
Statistical analysis of ROS levels in NIH 3T3 cells treated with SF and peptide. **
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PMC11335267
p < 0.001 (n = 8 per genotype) To address this question, we determined the expression of genes encoding orexigenic and anorexigenic peptides in the arcuate nucleus in mice fed ad libitum or subjected to fasting overnight.
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PMC7369657
These pieces of data coincide with the studies of other nanomaterials [52–54].
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PMC9429973
Summary/Conclusion: This randomized phase 3 study in AML patients not candidates for standard induction chemotherapy demonstrates that the oral FDC of DEC-C (35mg/100 mg) resulted in an equivalent DEC AUC exposure to IV-DEC at 20 mg/m over 5 days.
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PMC10958426
We found both the cell-cell interaction weight of cytokine signaling and cell-cell interaction weight of adhesion signaling in tumor tissue are significantly higher than that in normal tissue (Fig. 5E).
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PMC10545062
Lastly, while there was no statistical difference in the biomarkers of injury, there was notable increased variance in the SCC+ cohort when examining the data in graphical form.
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PMC11707832
In the past, α-mannosidosis was classified into three phenotypic subtypes, with type 1 designated as the mild form and type 3 as the severe form (Table 1).The majority of infants with α-mannosidosis are born without any apparent abnormalities.
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PMC9429973
The CD56 expression rate of the patients at the time of diagnosis was 42.5%, and the CD117 expression rate was 30.9%.
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PMC11462673
Nuclear proteins LMO4, LDB1, and SSBP2 and/or SSBP3 participate in cancer cell proliferation, invasion, migration, and angiogenesis, suggesting these nuclear proteins are vital regulators of head and neck squamous cell carcinoma (HNSCC) growth and metastasis .
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PMC11792090
Quantification results of CD45 integrated optical density (IOD). (
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PMC7185206
Mycoplasma testing was performed and negative on each cell line used.
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PMC6799808
In addition, in response to GLPT treatment, RIP3, which is involved in the regulation of necroptosis, was markedly upregulated in A549 cells but downregulated in A427 cells.
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PMC11535726
X. Tang, K.D. Hyde, Jayaward. &
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PMC11714165
Nevertheless, these NBD‐derived peptides have limitations in cancer therapy, such as lacking of targeted delivery and challenges in proteolytic degradation and adverse effects, which impede their therapeutic efficacy.
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PMC11806182
B Top ten miRNAs with the most significant fold changes PCOS has been associated with an elevated risk of developing UCEC.
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PMC6160470
However, all compounds were significantly less active than verapamil (p < 0.001).
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PMC11310713
Recovery of ovarian hormone production and negative feedback loop in GTB-treated OVX rats.
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PMC10667689
Increase in enzymatic activity of G6PD 48 h after Gal-9 treatment.
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PMC10759659
Clinical characteristics are plotted at the bottom.
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PMC11745355
Effect of selected agents on Pin1 degradation in cell.
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PMC11641532
Commonly used targeted drugs for ccRCC include tyrosine kinase inhibitors (TKIs), mechanistic target of rapamycin kinase (mTOR) inhibitors, immune checkpoint inhibitors, and hypoxia-inducible factor-2α inhibitors .
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PMC11519583
To investigate the proportion of EdU-positive MPs, MPs were transfected with the indicated siRNAs and cultured in DMEM containing 10% (v/v) FBS for 3 days.
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PMC11798926
We found that the YVPV→AVPA mutant significantly decreased the interaction with μ2 while the YMPI→AMPA did not; however, it was clear that the interaction was not eliminated completely.
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PMC9503541
MS1 had an accurate mass tolerance of 0.01 Da, while MS2 had a tolerance of 0.05 Da, and the identification score cutoff was set at 80%.
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PMC9429973
The clinical parameters studied were: age, gender, delay between onset of symptoms and treatment, Performance Status (PS), treatment protocol, Sanz Score, clinical presentation, severe bleeding during induction, thromboembolic events (TE), and differentiation syndrome (DS).
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PMC11127909
C EFHD1 domain architecture and schematic representation of the respective deletion constructs used in this study that were expressed in 143B cells.
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PMC11015054
This study aimed to investigate the role of METTL5 in HCC progression, and elucidate its possible molecular mechanisms in HCC via transcriptome sequencing, providing new insights for identifying new HCC prognostic markers and therapeutic targets.
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PMC11658074
j, k The protein expression of Col1, MMP9, and p21 in the two groups. *
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PMC11767793
We tested the residual absorbance of the AuNPs at λ = 490 nm after several rinses with warm PBS (Figure 6).
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PMC10926885
The interaction between NDE1 and DCTN1 was confirmed by western blot.
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PMC11787651
Human lung adenocarcinoma cell line NCI-H1437 (American Type Culture Collection) was cultured in RPMI1640 supplemented with 10% fetal bovine serum, GlutaMAX, and MEM Nonessential Amino Acids.
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PMC8658661
A low level of taurine was also observed in HepG2 cells, of which the primary role in the liver is conjugation with bile acids for excretion into bile .
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PMC11106977
However, the mechanisms regulating O-GlcNAcylation modification during this process are not fully understood.
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PMC11629143
CHO‐K1 cells (ATCC) were transfected with constructs expressing eGFP or mAb heavy and light chain genes driven by a CMV promoter.
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PMC9454852
ROS production data were expressed as fluorescence arbitrary units.
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PMC11462673
Red and blue indicate upregulated and downregulated genes, respectively.
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PMC11767725
Improvements persisted three weeks post-treatment (T28), though scores plateaued between T8 and T28.
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PMC11661040
KEGG enrichment analysis showed that CGREF1 might affect the neutrophil extracellular trap formation (Fig. 4B).
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PMC7305184
Two experiments (upper and lower panels) both for 15 generations, are shown.
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PMC11748363
The most dramatic decrease in activity was observed for compounds 5, 11, and 26, refer to Table 3.
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PMC9429973
Although the best therapeutic option for APL relapses was still controversial at that time, the patient was treated with the most updated approach, receiving an induction cycle of 30 days with the association of ATRA at the dose of 25 mg/m/die and ATO at the dose of 0.15 mg/Kg/die and a consolidation with 4 cycles of A...
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PMC11739670
KRN7000 (α‐galactosyl‐ceramide/αGalCer)‐CD1d/β2‐microglobulin complexes were generated by in vitro refolding, as previously described , biotinylated via an engineered BirA motif on the C‐terminus of CD1d, and further purified by size exclusion chromatography.
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PMC9429973
Numerous studies have shown lncRNA GAS5 expression level dysregulation in multiple cancers, but it was poorly investigated in AML.
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PMC11348300
The presented reoxygenation rate values are displayed with semitransparency to emphasize slow reoxygenation rates while obscuring the rapid reoxygenation rates observed in adjacent healthy tissues. (
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PMC6600253
We further investigated how PT induced replicative stress, and the results showed for the first time that PT inhibits hTERT enzymatic activity and protein expression, resulting in the subsequent induction of DNA damage, the activation of ATM/Chk2 and p53, and S phase arrest.
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PMC11637284
These experiments were complemented with two p166 mutants, termed p166-R1492A and p166-D1495A, in which either R1492 or D1495 were replaced by a neutral A (Fig 6E and 6F, left).
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PMC11695623
The results showed that the expression of DCUN1D5 was correlated with T stage, N stage, pathological stage, age and OSevent, but not with M stage, sex, primary site and smoking (Fig. 2).
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PMC11724582
The (A) heatmap and (B) volcano map are shown.
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PMC11066331
In the validation dataset, the accuracy of all classifiers was reduced.
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PMC6771295
LC3II/LC3I ratio was upregulated in resveratrol treated Mero-14 cells in which SIRT5 had been silenced (Figure 7Bii, compare bars 4 and 8).
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PMC9429973
Thrombocytopenia was seen in only 38.3%.
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PMC10419319
These findings suggest that isoalantolactone exhibits stronger cytotoxicity toward cisplatin-resistant OC cells than cisplatin-sensitive cells, highlighting its potential as a promising therapeutic agent.
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PMC9581083
N. tenuifolia is used to treat symptoms of common influenza (e.g., fever, headache, virus infections and sore throat) and is supported by pharmacological evidence of anti-inflammatory (Kim and Chung, 2018), immunomodulatory, antioxidative and antipruritic activities (Lin et al., 2018; Jeon et al., 2019).
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PMC11755467
For each experimental condition, at least two technical replicates were used with one negative control with no chemical modifier and one positive control (or denatured control DC) indicating the highest rate of modification for a target RNA.
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PMC9429973
The safety information was extracted from Argus database, a Novartis database where all adverse events related to Novartis compounds are stored.
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PMC9429973
Metabolic PET imaging was performed to routine protocols using Deauville criteria for response assessment.
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PMC11657695
This work therefore aimed to study the transcriptional regulation of KCNA2 and define the involvement of the Kv1.2 channel encoded by KCNA2 in a key function of ES development, cell proliferation.
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PMC10092581
These studies confirmed the ability of all [Se(NHC)]‐based complexes to target TrxR whereas GR activity was only very minimally affected.
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PMC10988555
The statistical analysis was done by the two-way ANOVA test against the DMSO control.
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PMC11787355
Moreover, the frequencies of effector cytokine- and cytolytic protein- expressing CD8 TCR-T cells were increased in an antigen-specific fashion (Fig. 3e, Supplementary Fig. 5b–d).
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PMC11487720
Also, see the enlarged figures in Fig. S1B UV/Cold shock-mediated BCD in WWOXf cell lines.
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