OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC10452486	Lynch et al. demonstrated that a significant proportion of the HLA-I content of exosomes exists in the form of disulfide-linked dimers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lynch", "et", "al...
PMC11545737	IMD is a life-threatening disease and survivors have long-term sequelae .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IMD", "is", "a", "life-threatening", "disease", "and", "survivors", "have", "long-term", "sequel...
PMC11743316	A better prognosis for patients with ovarian cancer and restoration of cisplatin sensitivity were the outcomes of the lowering of CRL4 and BIRC3 levels .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11583010	C, Quantification of phosphorylated H2A.X-positive cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", ",", "Quantification", "of", "phosphorylated", "H2A.X-positive", "cells", "." ] } ]
PMC9429973	Cells had been stimulated with various fungal, bacterial and viral pathogens, such as Candida albicans, Staphylococcus aureus, Influenza virus, Respiratory Syncytial virus and toll-like receptor ligands (TLR), such as lipopolysaccharide (TLR4), R848 (TLR7/8) or CpG (TLR9); subsequently cytokines (IFNa, IL-1b, IL-1Ra, I...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11088135	However, the relationship between lncRNA NUTM2A-AS1 and miR-376a-3p in glioma is unclear.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "relationship", "between", "lncRNA", "NUTM2A-AS1", "a...
PMC10761571	This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "research", "received", "n...
PMC4485786	NHS-IL12 induced pronounced cancer cell senescence, as documented by strong expression of senescence-associated p16 and nuclear translocation of p-HP1γ, and permanent arrest of cancer cell proliferation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11095939	Surgery was performed using the methodology described previously between 9:00 and 12:00 AM (Mitchell and Willenbring, 2008).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Surgery", "was", "performed"...
PMC11723947	In our bone marrow transplantation model, when transferred alone, wild-type and HP1γ-mutant Tconv mounted similar T cell-responses dominated by a Th1-phenotype (Fig. 5a-c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11401350	Thus, ICOS was considered a possible target for antibody based immunotherapy but still could eliminate healthy Tfh and B cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "ICOS...
PMC11696659	While the AUC was 0.79 for the high-prevalence model, it was 0.98 for the low-prevalence model, suggesting that telomere length determination, together with TAV analysis, could help and could be of use in the screening of high-risk patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10158546	However, through repeated measurements of amyloid seeding activity in 6-week time course experiments, we failed to observe any evidence of prion replication within the differentiated ReN cultures following challenge with four prion isolates (human sCJD subtypes MM1 and VV2, and rodent adapted scrapie strains RML and 26...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10899471	It has also been reported that miR-939 could induce mRNA degradation of its target gene (40), further supporting our results.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", ...
PMC11461833	The experiment was repeated three times.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "experiment", "was", "repeated", "three", "times", "." ] } ]
PMC10329074	At present, surgery is still the main treatment for ccRCC (Jonasch et al. 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "present", ",", "surgery", "is", "stil...
PMC11543935	The ablation device was precisely inserted through vertical movement on the rail into the phantom placed in cutout of the glass bottom.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ablat...
PMC11271278	We have made the HAPI analysis tool publicly available (10.24433/CO.1110712.v1) and anticipate its broader application in cancer driver discovery and mechanism investigation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9966931	The chromatographic conditions used were as follows: He as carrier gas at a flow rate of 1 mL/min; injector temperature = 300 °C, with a split ratio of 40:1; initial oven temperature = 70 °C (0 min), with a first ramp of 6 °C/min up to 250 °C (30 min), followed by a second ramp of 90 °C/min up to 290 °C, and a third st...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	However, there was no difference between patients with SAA and NSAA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "there", "was", "no", "difference", "between", "patients", "with"...
PMC9429973	A total of 109 pts (63%) received FLAG-IDA, while the rest got FLAG-GO therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "total", "of", "109", "pts", ...
PMC9429973	R. Tilmont, I. Yakoub-Agha, D.-J. Eikema, N. Zinger, M. Haenel, N. Schaap, C. Herrera Arroyo, C. Schuermans, W. Bethge, M. Engelhardt, J. Kuball, M. Michieli, N. Schub, K. M. O. Wilson, J. H. Bourhis, M. V. Mateos, N. Robin, E. Jost, N. Kröger, J. M. Moraleda, S. Sica, P. J. Hayden, M. Beksac, S. Schönland, S. Manier H...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11224020	This is in sharp contrast to microbe-induced DC migration to lymph nodes that leads to activation of T cells capable of fighting these infectious agents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11803149	Data were normalized using the LogNormalize function.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "were", "normalized", "using", "the", "LogNormalize", "function", "." ] } ]
PMC9621239	D and E) The comparisons of diversity were quantified using D at the amino acid level (D) and quantified using D, dS and dN at the nucleotide level (E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11752767	Thereafter, cancer/testis antigens, including NY-ESO-1 and MAGE family proteins, have been extensively studied on account of their attributes of being expressed primarily in germline cells and rarely in normal somatic cells [68, 74–76].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11572213	In addition, siRNA-mediated TET2 knockdown increased the proliferation of cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "siRNA-mediated", "TET2", "knockdown", "increased", "the", ...
PMC10957991	However, a significant decrease in their levels was detected on stiffer environment, i.e. on plastic cell culture dishes (Fig. 2A,B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	The exact mechanism and efficacy of CDK6 degraders in AML subtypes remain unknown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "exact", "mechanism", "and", "efficacy", "of", "CDK6", "degraders", ...
PMC11536589	The presence of constantly activated KRAS mutations directs the rearrangement of lipid metabolism and promote the generation of the excessive amount of ROS in cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11694066	The trial met its primary endpoint, supporting further investigation of this combination.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "trial", "met", "its", "primary", "endpoint", ",", "supporting", ...
PMC9436459	M. yunanensis), M. wittiorum, S. bonplandii, and S. ilicifolia Type C: Dehydroprenylchalcone type MDAAs 15 compounds (77 − 91) distributed in 12 species: A. heterophyllus, A. integer, B. oblongifolia, D. barteri, M. alba (including M. alba var.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5925824	Panel b: Position N63 on human PD-L1 is a specificity anchor for LY3300054.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Panel", "b", ":", "Position", "N63", "on", "human", "PD-L1", ...
PMC11594074	Ki-67 is an essential proliferation marker, and its expression in a tumor cell can be utilized as an indicator for prognosis, alongside other markers .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC7709199	GD-derived crystals from the initial condition diffracted to 2.5 Å resolution and further optimization of the conditions resulted in a complete data set from a single crystal at 1.85 Å resolution (Table 2 ▸).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In 2/7 patients with MF and 2/3 with EMF, clonality was not detected, while the fraction of the dominant T-cell clone did not exceed 4.2%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10778532	At low density, VHL-C162F cells seems to be less aggressive than at high density.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "low", "density", ",", "VHL-C162F", "cells", "seems", ...
PMC11098378	Given that the substrates of IpaH4 are unknown, we conducted in vitro autoubiquitination experiments with GST-tagged IpaH4 (GST-IpaH4) purified from E. coli.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11200978	Within each individual experiment, protein samples were collected from a minimum of three replicates, pooled, and then analyzed (N ≥ 3; n ≥ 9).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9964635	According to in silico modelling studies, 7f has an outstanding docking score with the lowest binding energy of −170.066 kcal/mol, which is lower than the reference ligand X39 for protein kinase B (−130.624 kcal/mol).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10502403	Table 1Summary of gene set enrichment analysis (GSEA): detected mitochondrial metabolism-related gene setsGene setSIZEUnstimulated NE1-GMCs per unstimulated NGMCsNE1-pMHC-stimulated NE1-GMCs per IMMU510-stimulated NGMCsESNESNOM p valueFDR q-valueESNESNOM p valueFDR q-valueWP_MITOCHONDRIAL_COMPLEX_III_ASSEMBLY150.691.44...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11419566	CHOP/XBP-1 could also activate caspase-8, thus inducing downstream caspase-9 activation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CHOP/XBP-1", "could", "also", "activate", "caspase-8", ",", "thus", "inducing", "downstream...
PMC9429973	Summary/Conclusion: While there is an overall bias between DLA R2-MRI and SDPA R2-MRI, the bias does not result in unacceptable sensitivities and specificities of DLA R2-MRI for predicting SDPA R2-MRI results above the clinically relevant LIC thresholds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In addition, defects in cytoskeletal proteins are reported to contribute to immunological dysfunction and disruption of normal immune processes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", ...
PMC8759873	The proliferation curve (Figure 4) showed that there was no difference between untreated and transfected pcDNA3.1(+) 786-0 cell growth curves (P > 0.05), indicating that the cell proliferation characteristics after transfection with empty vector were not affected.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O"...
PMC9429973	Studies by Kittai (2021) and Al-Sawaf (2020) showed the impact of karyotypic complexity on survival in patients with chronic lymphocytic leukemia (CLL) treated with ibrutinib or venetoclax.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11703992	B Enriched protein pathways of causal plasma protein, conducted by proteomaps.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "Enriched", "protein", "pathways", "of", "causal", "plasma", "protein", ",",...
PMC11531735	HuHer2-6 originated from spontaneous metastasis that occurred within 6–12 months of Hu-Her2 transgenic mice, while HuHer2-Lu2 (L2) was developed from lung metastasis that occurred at around 40 weeks of age.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9268620	Similarly, there were no morphological changes compared to the control in the treatments using 1 and 3 μg/mL of damnacanthal (Figure 9).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10887351	β3-AR stimulation induced significant relaxation of myometrial contractions via a cAMP/PKA mechanism .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "β3-AR", "stimulation", "induced", "significant", "relaxation", "of", "myometrial", "co...
PMC6617630	Our finding is consistent with previous studies in hematological disease models of multiple myeloma (MYC-dependent) and acute myeloid leukemia, where it was demonstrated that BET inhibition produces a potent anti-proliferative effect .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8336407	400 g of powder was extracted with 2000 mL methanol (63%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "400", "g", "of", "powder", "was", "extracted", "with", "2000", ...
PMC11682525	These therapies exhibit distinct mechanisms of action, isolation methodologies, immunophenotypic profiles, and regulatory considerations ( 1 ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "therapies", "exhibi...
PMC11725127	Finally, we explored USP2's clinical significance in MM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "we", "explored", "USP2", "'s", "clinical", "significance", "in", "MM", "."...
PMC11698348	Selected single channel images of staining have been provided in S1 Fig. (f) FACS isolation: C57Bl/6 wild-type mice aged 7–9 weeks were used to isolate HF bulge SCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", ...
PMC11040965	The methylation level of each of these regions was expressed as the average β value for the differentially methylated probes that map to it.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11615101	P ≤0.05, *** P ≤0.001).Abbreviations: WB, Western blot; ns, non-significant; NS, non-specific siRNA; UT, untreated; Co-IP, co-immunoprecipitation; TNF, Tumor Necrosis Factor; IgG, Immunoglobulin; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10529414	The cells were grown to 80% confluence in 100 mm culture plates and subjected to crosslinking with 1% formaldehyde in 1X PBS for 10 min at room temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11607321	These are also commonly utilized in multi-omics integration and are among the most informative omic types for our benchmarks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "are", "also", "commonly"...
PMC11138140	At 0 h, the average optical volumes of the individual untreated cardiomyocytes (n = 256) were 1380 ± 501 μm and that of the norepinephrine-treated cardiomyocytes (n = 187) were slightly decreased at 1074 ± 501 μm (Figure 1D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10055960	Additionally, the linear regression of each dose–response dataset was also analyzed in the 95% confidence interval.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "the", ...
PMC11247842	This QTL was close to the QTL identified by US study on BTA13.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "QTL", "was", "close", "to", "the", "QTL", "identified", "by",...
PMC5673955	Jurkat cells were more sensitive to high concentrations of RrA (1–50 U/mL) in comparison with normal CD4.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Jurkat", "cells", "were", ...
PMC9429973	Among patients treated with carfilzomib-based therapies (N=6), 3 patients achieved CR/VGPRH and one achieved PRH.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "patients", "treated", "with", ...
PMC7802142	The HFs in the anagen phase exhibited typical features, such as a larger hair bulb, thicker skin, more bulbs in the subcutis, as well as larger amounts of melanin .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10998613	For comparison, we transiently transfected DKO MDA-MB-231 with CXCR4-AcGFP1 and β2AR-mCherry plasmids at the same levels as for the PIE-FCCS experiments and observed a significant increase in surface expression by flow cytometry (SI Appendix, Fig. S1B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11643361	Certain breast cancer cell lines express the NMDA and NMDAR2 receptors, which play a critical role in breast cancer progression .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Certain", "breast", ...
PMC9429973	Over the study period, PI-based treatments were preferred in L1, IMID-based in L2 and antiCD38 for 30% of patients in L3 and L4+.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	A total of 100 (59.2%) patients completed the 24-month observation period.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "total", "of", "100", "(", "59.2", "%", ")", "patients...
PMC6684588	Data are means ± SEM (n = 8–9 per group). ***	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "means", "±", "SEM", "(", "n", "=", ...
PMC9325715	The oxidation process also can lead to protein degradation, which should be the reason for the protein degradation seen on the reducing SDS-PAGE.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9684669	The two-tailed unpaired Student’s test of the mean was used for single comparisons of statistical significance between experimental groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "two-tailed", "unpaire...
PMC11588085	Within Grade 3 tumors, lower XIST expression was also associated with poor survival (41.63 vs. 48.20 mo, Fig. 1E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Within"...
PMC11463018	Key residues were labelled in green as sticks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Key", "residues", "were", "labelled", "in", "green", "as", "sticks", "." ] } ]
PMC11489275	The study enrolled 263 effective patients of anti-MDA5 + DM-ILD who were diagnosed in four centers from 2017 to 2021, including The Affiliated Drum Tower Hospital of Nanjing University Medical School, Affiliated Hospital of Xuzhou Medical University, The Third People’s Hospital of Chengdu, and General Hospital of Ningx...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Using mutation-specific gRNA and CRISPR-Cas9 system, we made an attempt to repair patients-derived iPS cells which may have potential for renewal of the corrected granulocyte population in the bone marrow.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9268620	The combined filtrate was evaporated under reduced pressure to give a brown-colored residue.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "combined", "filtrate", "was", "evaporated", "under", "reduced", "pre...
PMC5386478	It has been demonstrated that induced TG2 expression confers a growth advantage to cancer cells to survive in hypoxic conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "been", "d...
PMC11478724	Our study showed there was a statistically significant rise in the percentage of apoptosis, ROS production, and LDH release, caspase 3, 7 activities after PMX treatment, and there was a marked drop in survival rate, and migration compared to the control group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11585254	no. 340–500).	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "no.", "340–500", ")", "." ] } ]
PMC11623887	A.A. and K.F.: designed the project and did experiments; M.B. and L.J.: wrote the manuscript.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A.A.", "and", "K.F.", ":", "designed",...
PMC9429973	The risk of cerebral venous sinus thrombosis was lower in MPNs with co-occurring HTN.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "risk", "of", "cerebral", "venous", "sinus", "thrombosis", ...
PMC9429973	8 countries reported Dasatinib available: Argentina, Colomboa, Chile, Dominican Republic, Mexico, Nicaragua, Peru, and Uruguay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "8", ...
PMC8973725	The results showed that ZNF677 was methylated in 51 out of 60 (85%) ccRCC tissues and 2 out of 47 (4.2%) normal tissues (Figure 3d; Table 1), suggesting frequent methylation of ZNF677 in ccRCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11388384	Microscopic detection of SHH, using immunofluorescence against native SHH (Left) or imaging SHH-Halo with TIRF microscopy (Right).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Microscopic", ...
PMC10607604	BRCA, predisposition genes for ovarian and breast carcinoma, predict higher sensitivity to DNA-targeting chemotherapy drugs, including platinum agents .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BRCA", ",", "pred...
PMC10938336	By mapping these compounds onto pathways directly associated with cancer, a more nuanced understanding of their potential therapeutic effects is achieved.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "By", "mappin...
PMC11767817	5637 cells were seeded at a density of 0.4 × 10 in a 6-well plate and incubated for 24 h at standard cell culture conditions.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ],...
PMC9429973	Average in-laboratory turn-around-time for these cases was 1.8 days, with an average of 3.3 days from sample receipt to final report.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Average", "i...
PMC10165258	The value of the IC50 is then divided by the mean value of the IC50 for the two drugs alone to obtain the Fractional Inhibitory Concentration (FIC).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Primary arterial hypertension (HTN) remains one of the most common comorbidities in the elderly.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Primary", "arterial", "hypertension", "(", "HTN", ")",...
PMC11082662	Although ACER2 is recognized as an important component in inducing cellular ceramide hydrolysis to influence carcinoma cell replication, the specific mechanisms related to ovarian carcinoma are not well established.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8140214	ROS are generated atlow quantities during normal cell metabolism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ROS", "are", "generated", "atlow", "quantities", "during", "normal", "cell", "metabolism", "." ] } ]
PMC11787355	Specific OD is ODPTPRZ1-ODFlu.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Specific", "OD", "is", "ODPTPRZ1-ODFlu", "." ] } ]
PMC10914904	For instance, HuR can bind to TGFβ1, TNF, and Cox2 mRNA, decreasing the stability of TGFβ1 mRNA and reducing the protein levels and secretion of Cox2 and TNF during lipopolysaccharide (LPS)-induced macrophage stimulation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10454535	Other studies have demonstrated cytotoxic effects of RES and PIC in MM cells , and we show PIN is an additional RES derivative exhibiting MM cytotoxicity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC8633974	All RT-qPCR reactions were performed as technical triplicates using the following thermal cycler conditions: 3 minutes 95C; 60 cycles of 95C for 15 seconds, 60C for 60 seconds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9599726	The results showed that VP reduced the expression of TFRC mRNA in both GIST882 and GIST48 cells after 24 h of treatment (Figure 7A, upper panels).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC9429973	Methods: Human Umbilical Vein Endothelial Cells (HUVECs) cultured in flow condition for 24 hours were perfused by either serum only (decomplemented or not) or serum containing either whole hemolysate (sonicated RBCs) or different hemolysate components or RBCs membranes (ghosts) under shear stress 1 dyne/cm2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11469524	Overlap of differentially regulated phosphosites (limma, FDR≤5%) for indicated selected comparisons. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overlap", "of", "differentially", "regulated", "phosphosites...

PMC10452486

Lynch et al. demonstrated that a significant proportion of the HLA-I content of exosomes exists in the form of disulfide-linked dimers.

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PMC11545737

IMD is a life-threatening disease and survivors have long-term sequelae .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IMD", "is", "a", "life-threatening", "disease", "and", "survivors", "have", "long-term", "sequel...

PMC11743316

A better prognosis for patients with ovarian cancer and restoration of cisplatin sensitivity were the outcomes of the lowering of CRL4 and BIRC3 levels .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11583010

C, Quantification of phosphorylated H2A.X-positive cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", ",", "Quantification", "of", "phosphorylated", "H2A.X-positive", "cells", "." ] } ]

PMC9429973

Cells had been stimulated with various fungal, bacterial and viral pathogens, such as Candida albicans, Staphylococcus aureus, Influenza virus, Respiratory Syncytial virus and toll-like receptor ligands (TLR), such as lipopolysaccharide (TLR4), R848 (TLR7/8) or CpG (TLR9); subsequently cytokines (IFNa, IL-1b, IL-1Ra, I...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11088135

However, the relationship between lncRNA NUTM2A-AS1 and miR-376a-3p in glioma is unclear.

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PMC10761571

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "research", "received", "n...

PMC4485786

NHS-IL12 induced pronounced cancer cell senescence, as documented by strong expression of senescence-associated p16 and nuclear translocation of p-HP1γ, and permanent arrest of cancer cell proliferation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11095939

Surgery was performed using the methodology described previously between 9:00 and 12:00 AM (Mitchell and Willenbring, 2008).

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PMC11723947

In our bone marrow transplantation model, when transferred alone, wild-type and HP1γ-mutant Tconv mounted similar T cell-responses dominated by a Th1-phenotype (Fig. 5a-c).

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PMC11401350

Thus, ICOS was considered a possible target for antibody based immunotherapy but still could eliminate healthy Tfh and B cells.

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PMC11696659

While the AUC was 0.79 for the high-prevalence model, it was 0.98 for the low-prevalence model, suggesting that telomere length determination, together with TAV analysis, could help and could be of use in the screening of high-risk patients.

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PMC10158546

However, through repeated measurements of amyloid seeding activity in 6-week time course experiments, we failed to observe any evidence of prion replication within the differentiated ReN cultures following challenge with four prion isolates (human sCJD subtypes MM1 and VV2, and rodent adapted scrapie strains RML and 26...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10899471

It has also been reported that miR-939 could induce mRNA degradation of its target gene (40), further supporting our results.

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PMC11461833

The experiment was repeated three times.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "experiment", "was", "repeated", "three", "times", "." ] } ]

PMC10329074

At present, surgery is still the main treatment for ccRCC (Jonasch et al. 2021).

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PMC11543935

The ablation device was precisely inserted through vertical movement on the rail into the phantom placed in cutout of the glass bottom.

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PMC11271278

We have made the HAPI analysis tool publicly available (10.24433/CO.1110712.v1) and anticipate its broader application in cancer driver discovery and mechanism investigation.

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PMC9966931

The chromatographic conditions used were as follows: He as carrier gas at a flow rate of 1 mL/min; injector temperature = 300 °C, with a split ratio of 40:1; initial oven temperature = 70 °C (0 min), with a first ramp of 6 °C/min up to 250 °C (30 min), followed by a second ramp of 90 °C/min up to 290 °C, and a third st...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

However, there was no difference between patients with SAA and NSAA.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "there", "was", "no", "difference", "between", "patients", "with"...

PMC9429973

A total of 109 pts (63%) received FLAG-IDA, while the rest got FLAG-GO therapy.

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PMC9429973

R. Tilmont, I. Yakoub-Agha, D.-J. Eikema, N. Zinger, M. Haenel, N. Schaap, C. Herrera Arroyo, C. Schuermans, W. Bethge, M. Engelhardt, J. Kuball, M. Michieli, N. Schub, K. M. O. Wilson, J. H. Bourhis, M. V. Mateos, N. Robin, E. Jost, N. Kröger, J. M. Moraleda, S. Sica, P. J. Hayden, M. Beksac, S. Schönland, S. Manier H...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11224020

This is in sharp contrast to microbe-induced DC migration to lymph nodes that leads to activation of T cells capable of fighting these infectious agents.

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PMC11803149

Data were normalized using the LogNormalize function.

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PMC9621239

D and E) The comparisons of diversity were quantified using D at the amino acid level (D) and quantified using D, dS and dN at the nucleotide level (E).

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PMC11752767

Thereafter, cancer/testis antigens, including NY-ESO-1 and MAGE family proteins, have been extensively studied on account of their attributes of being expressed primarily in germline cells and rarely in normal somatic cells [68, 74–76].

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PMC11572213

In addition, siRNA-mediated TET2 knockdown increased the proliferation of cancer cells.

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PMC10957991

However, a significant decrease in their levels was detected on stiffer environment, i.e. on plastic cell culture dishes (Fig. 2A,B).

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PMC9429973

The exact mechanism and efficacy of CDK6 degraders in AML subtypes remain unknown.

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PMC11536589

The presence of constantly activated KRAS mutations directs the rearrangement of lipid metabolism and promote the generation of the excessive amount of ROS in cancer cells.

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PMC11694066

The trial met its primary endpoint, supporting further investigation of this combination.

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PMC9436459

M. yunanensis), M. wittiorum, S. bonplandii, and S. ilicifolia Type C: Dehydroprenylchalcone type MDAAs 15 compounds (77 − 91) distributed in 12 species: A. heterophyllus, A. integer, B. oblongifolia, D. barteri, M. alba (including M. alba var.

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PMC5925824

Panel b: Position N63 on human PD-L1 is a specificity anchor for LY3300054.

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PMC11594074

Ki-67 is an essential proliferation marker, and its expression in a tumor cell can be utilized as an indicator for prognosis, alongside other markers .

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PMC7709199

GD-derived crystals from the initial condition diffracted to 2.5 Å resolution and further optimization of the conditions resulted in a complete data set from a single crystal at 1.85 Å resolution (Table 2 ▸).

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PMC9429973

In 2/7 patients with MF and 2/3 with EMF, clonality was not detected, while the fraction of the dominant T-cell clone did not exceed 4.2%.

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PMC10778532

At low density, VHL-C162F cells seems to be less aggressive than at high density.

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PMC11098378

Given that the substrates of IpaH4 are unknown, we conducted in vitro autoubiquitination experiments with GST-tagged IpaH4 (GST-IpaH4) purified from E. coli.

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PMC11200978

Within each individual experiment, protein samples were collected from a minimum of three replicates, pooled, and then analyzed (N ≥ 3; n ≥ 9).

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PMC9964635

According to in silico modelling studies, 7f has an outstanding docking score with the lowest binding energy of −170.066 kcal/mol, which is lower than the reference ligand X39 for protein kinase B (−130.624 kcal/mol).

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PMC10502403

Table 1Summary of gene set enrichment analysis (GSEA): detected mitochondrial metabolism-related gene setsGene setSIZEUnstimulated NE1-GMCs per unstimulated NGMCsNE1-pMHC-stimulated NE1-GMCs per IMMU510-stimulated NGMCsESNESNOM p valueFDR q-valueESNESNOM p valueFDR q-valueWP_MITOCHONDRIAL_COMPLEX_III_ASSEMBLY150.691.44...

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PMC11419566

CHOP/XBP-1 could also activate caspase-8, thus inducing downstream caspase-9 activation.

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PMC9429973

Summary/Conclusion: While there is an overall bias between DLA R2-MRI and SDPA R2-MRI, the bias does not result in unacceptable sensitivities and specificities of DLA R2-MRI for predicting SDPA R2-MRI results above the clinically relevant LIC thresholds.

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PMC9429973

In addition, defects in cytoskeletal proteins are reported to contribute to immunological dysfunction and disruption of normal immune processes.

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PMC8759873

The proliferation curve (Figure 4) showed that there was no difference between untreated and transfected pcDNA3.1(+) 786-0 cell growth curves (P > 0.05), indicating that the cell proliferation characteristics after transfection with empty vector were not affected.

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PMC9429973

Studies by Kittai (2021) and Al-Sawaf (2020) showed the impact of karyotypic complexity on survival in patients with chronic lymphocytic leukemia (CLL) treated with ibrutinib or venetoclax.

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PMC11703992

B Enriched protein pathways of causal plasma protein, conducted by proteomaps.

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PMC11531735

HuHer2-6 originated from spontaneous metastasis that occurred within 6–12 months of Hu-Her2 transgenic mice, while HuHer2-Lu2 (L2) was developed from lung metastasis that occurred at around 40 weeks of age.

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PMC9268620

Similarly, there were no morphological changes compared to the control in the treatments using 1 and 3 μg/mL of damnacanthal (Figure 9).

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PMC10887351

β3-AR stimulation induced significant relaxation of myometrial contractions via a cAMP/PKA mechanism .

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PMC6617630

Our finding is consistent with previous studies in hematological disease models of multiple myeloma (MYC-dependent) and acute myeloid leukemia, where it was demonstrated that BET inhibition produces a potent anti-proliferative effect .

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PMC8336407

400 g of powder was extracted with 2000 mL methanol (63%).

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PMC11682525

These therapies exhibit distinct mechanisms of action, isolation methodologies, immunophenotypic profiles, and regulatory considerations ( 1 ).

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PMC11725127

Finally, we explored USP2's clinical significance in MM.

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PMC11698348

Selected single channel images of staining have been provided in S1 Fig. (f) FACS isolation: C57Bl/6 wild-type mice aged 7–9 weeks were used to isolate HF bulge SCs.

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PMC11040965

The methylation level of each of these regions was expressed as the average β value for the differentially methylated probes that map to it.

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PMC11615101

P ≤0.05, *** P ≤0.001).Abbreviations: WB, Western blot; ns, non-significant; NS, non-specific siRNA; UT, untreated; Co-IP, co-immunoprecipitation; TNF, Tumor Necrosis Factor; IgG, Immunoglobulin; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes.

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PMC10529414

The cells were grown to 80% confluence in 100 mm culture plates and subjected to crosslinking with 1% formaldehyde in 1X PBS for 10 min at room temperature.

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PMC11607321

These are also commonly utilized in multi-omics integration and are among the most informative omic types for our benchmarks.

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PMC11138140

At 0 h, the average optical volumes of the individual untreated cardiomyocytes (n = 256) were 1380 ± 501 μm and that of the norepinephrine-treated cardiomyocytes (n = 187) were slightly decreased at 1074 ± 501 μm (Figure 1D).

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PMC10055960

Additionally, the linear regression of each dose–response dataset was also analyzed in the 95% confidence interval.

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PMC11247842

This QTL was close to the QTL identified by US study on BTA13.

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PMC5673955

Jurkat cells were more sensitive to high concentrations of RrA (1–50 U/mL) in comparison with normal CD4.

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PMC9429973

Among patients treated with carfilzomib-based therapies (N=6), 3 patients achieved CR/VGPRH and one achieved PRH.

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PMC7802142

The HFs in the anagen phase exhibited typical features, such as a larger hair bulb, thicker skin, more bulbs in the subcutis, as well as larger amounts of melanin .

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PMC10998613

For comparison, we transiently transfected DKO MDA-MB-231 with CXCR4-AcGFP1 and β2AR-mCherry plasmids at the same levels as for the PIE-FCCS experiments and observed a significant increase in surface expression by flow cytometry (SI Appendix, Fig. S1B).

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PMC11643361

Certain breast cancer cell lines express the NMDA and NMDAR2 receptors, which play a critical role in breast cancer progression .

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PMC9429973

Over the study period, PI-based treatments were preferred in L1, IMID-based in L2 and antiCD38 for 30% of patients in L3 and L4+.

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PMC9429973

A total of 100 (59.2%) patients completed the 24-month observation period.

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PMC6684588

Data are means ± SEM (n = 8–9 per group). ***

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PMC9325715

The oxidation process also can lead to protein degradation, which should be the reason for the protein degradation seen on the reducing SDS-PAGE.

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PMC9684669

The two-tailed unpaired Student’s test of the mean was used for single comparisons of statistical significance between experimental groups.

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PMC11588085

Within Grade 3 tumors, lower XIST expression was also associated with poor survival (41.63 vs. 48.20 mo, Fig. 1E).

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PMC11463018

Key residues were labelled in green as sticks.

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PMC11489275

The study enrolled 263 effective patients of anti-MDA5 + DM-ILD who were diagnosed in four centers from 2017 to 2021, including The Affiliated Drum Tower Hospital of Nanjing University Medical School, Affiliated Hospital of Xuzhou Medical University, The Third People’s Hospital of Chengdu, and General Hospital of Ningx...

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PMC9429973

Using mutation-specific gRNA and CRISPR-Cas9 system, we made an attempt to repair patients-derived iPS cells which may have potential for renewal of the corrected granulocyte population in the bone marrow.

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PMC9268620

The combined filtrate was evaporated under reduced pressure to give a brown-colored residue.

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PMC5386478

It has been demonstrated that induced TG2 expression confers a growth advantage to cancer cells to survive in hypoxic conditions.

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PMC11478724

Our study showed there was a statistically significant rise in the percentage of apoptosis, ROS production, and LDH release, caspase 3, 7 activities after PMX treatment, and there was a marked drop in survival rate, and migration compared to the control group.

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PMC11585254

no. 340–500).

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PMC11623887

A.A. and K.F.: designed the project and did experiments; M.B. and L.J.: wrote the manuscript.

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PMC9429973

The risk of cerebral venous sinus thrombosis was lower in MPNs with co-occurring HTN.

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PMC9429973

8 countries reported Dasatinib available: Argentina, Colomboa, Chile, Dominican Republic, Mexico, Nicaragua, Peru, and Uruguay.

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PMC8973725

The results showed that ZNF677 was methylated in 51 out of 60 (85%) ccRCC tissues and 2 out of 47 (4.2%) normal tissues (Figure 3d; Table 1), suggesting frequent methylation of ZNF677 in ccRCC.

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PMC11388384

Microscopic detection of SHH, using immunofluorescence against native SHH (Left) or imaging SHH-Halo with TIRF microscopy (Right).

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PMC10607604

BRCA, predisposition genes for ovarian and breast carcinoma, predict higher sensitivity to DNA-targeting chemotherapy drugs, including platinum agents .

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PMC10938336

By mapping these compounds onto pathways directly associated with cancer, a more nuanced understanding of their potential therapeutic effects is achieved.

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PMC11767817

5637 cells were seeded at a density of 0.4 × 10 in a 6-well plate and incubated for 24 h at standard cell culture conditions.

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PMC9429973

Average in-laboratory turn-around-time for these cases was 1.8 days, with an average of 3.3 days from sample receipt to final report.

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PMC10165258

The value of the IC50 is then divided by the mean value of the IC50 for the two drugs alone to obtain the Fractional Inhibitory Concentration (FIC).

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PMC9429973

Primary arterial hypertension (HTN) remains one of the most common comorbidities in the elderly.

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PMC11082662

Although ACER2 is recognized as an important component in inducing cellular ceramide hydrolysis to influence carcinoma cell replication, the specific mechanisms related to ovarian carcinoma are not well established.

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PMC8140214

ROS are generated atlow quantities during normal cell metabolism.

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PMC11787355

Specific OD is ODPTPRZ1-ODFlu.

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PMC10914904

For instance, HuR can bind to TGFβ1, TNF, and Cox2 mRNA, decreasing the stability of TGFβ1 mRNA and reducing the protein levels and secretion of Cox2 and TNF during lipopolysaccharide (LPS)-induced macrophage stimulation .

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PMC10454535

Other studies have demonstrated cytotoxic effects of RES and PIC in MM cells , and we show PIN is an additional RES derivative exhibiting MM cytotoxicity.

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PMC8633974

All RT-qPCR reactions were performed as technical triplicates using the following thermal cycler conditions: 3 minutes 95C; 60 cycles of 95C for 15 seconds, 60C for 60 seconds.

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PMC9599726

The results showed that VP reduced the expression of TFRC mRNA in both GIST882 and GIST48 cells after 24 h of treatment (Figure 7A, upper panels).

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PMC9429973

Methods: Human Umbilical Vein Endothelial Cells (HUVECs) cultured in flow condition for 24 hours were perfused by either serum only (decomplemented or not) or serum containing either whole hemolysate (sonicated RBCs) or different hemolysate components or RBCs membranes (ghosts) under shear stress 1 dyne/cm2.

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PMC11469524

Overlap of differentially regulated phosphosites (limma, FDR≤5%) for indicated selected comparisons. (

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