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PMC11658074
Furthermore, AMPK upregulates nuclear factor E2-related factor 2 (Nrf2) for antioxidant enzyme synthesis .
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PMC11754291
Cellular metabolic activity was assessed using the AlamarBlue HS assay, α-Melanocyte-Stimulating Hormone (α-MSH) production by keratinocytes was quantified using ELISA, and Western blotting was used to assess pro-melanogenic factor expression in melanocytes.
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PMC9429973
D. Kuter, H. Goldschmidt, D. Cella, M. T. Petrucci, P. Moreau, B. Durie, A. Juarez-Garcia, L. Trong, J. Gu, G. Hernandez Rivera, S. Dhanasiri, T. Marshall, J. Wang, L. Lacoin, K. Ramasamy, R. Vij Hematology Division, Massachusetts General Hospital, Boston, MA, United States of America; University Hospital Heidelberg, I...
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PMC11474209
Edge of surface-confined [Ru (NH3)6]3+ separates in the presence of MC-LR, culminating in decreased faradaic potential from the reduction of [Ru(NH3)6] to [Ru(NH3)6] and a decline in square wave voltammetry.
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PMC11674891
Future studies should aim to identify the transcription factors or mechanisms through which AKT signaling enhances CRABP2 and FNDC4 expression.
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PMC11394730
Piperine interferes with the abnormal mechanisms of the cancer cells in many ways.
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PMC11300639
ns, not significant; **, P < 0.01.
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PMC9429973
Due to severe COVID-19, we decided to hold Glofitamab.
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PMC8557138
The NA8 spheroids showed the upregulation of the genes encoding VEGF, Ephrin A1 and Angiopoietin-like 4 in comparison to that in the monolayer.
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PMC9429973
Stategy includes Dara-KRD induction (6 cycles), autologous stem cell transplantation (ASCT), Dara-KRD consolidation (4 cycles), second ASCT, Dara-lenalidomide maintenance.
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PMC11322866
The SAHF is a multi-layered structure centered on a condensed heterochromatic core.
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PMC9672323
The anticancer effects of piroxicam have been indicated in some in vitro studies.
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PMC11637276
The former constitutes the PP2A complex in 90% of assemblies .
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PMC11506827
GEF also had a significant amount of LPA C18:2, making up 0.19% of the sample, along with smaller amounts of other lysolipids (LPLs) like LPC, LPE, and LPI, resulting in a total LPL content of 0.52%.
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PMC11653168
Although its 5-year survival rate is ~90%, 20% of children with ALL experience relapse with a poor prognosis (7); in adults, the relapse rate is higher, reaching 40–50% (8,9).
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PMC10809689
The trend of α-KG concentration after 72 h treatment with galectin-9 in the HL-60 (a) and 24 h treatment with gal-9 in THP-1 (b) cell lines was decreasing in comparison to PMA (p = 0.001, p = 0.001) and control (p = 0.03, p = 0.0001) groups, respectively. (*
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PMC11594588
In the context of mitochondrial disorders, we are talking about the receptor-mediated activation of TLR1, TLR2, and TLR4 subtypes.
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PMC2614415
In addition, amplification of human chromosome 20q13.2, which contains Aurora-A, frequently occurs in ovarian cancer .
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PMC9429973
The effects of bcor mutations on cell proliferation, cell cycle progression, and cell apoptosis were detected by CCK8 assay, colony formation assay, and flow cytometry.
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PMC11653533
Additionally, methanolic extracts of F. auriculata leaf showed antibacterial activity against E. coli, which causes diarrhea, abdominal torment, and fever, and S. typhimurium, which causes gastroenteritis with the zone of inhibition esteem of 18.33 ± 0.67 mm and 17.67 ± 0.33 mm at a concentration of 850 μg/mL w/v respe...
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PMC10878518
Telomerase is a key enzyme for keeping the telomere length and human telomerase reverse transcriptase (hTERT) expression is often activated in most human cancers, including bone and soft-tissue sarcomas.
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PMC11748335
H3K27me3 tends to localize at CGIs and is thought to regulate plasticity .
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PMC9429973
Spermidine serves as a precursor for hypusine, required for activation of the eIF5A translation factor.
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PMC10040136
Approximately 70–80% of GISTs harbor a mutation in the KIT (CD117) or platelet-derived growth factor receptor-alpha (PDGFRA) genes.
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PMC7351993
Specifically, when the intensity of the event detection signal exceeds a specified threshold value, the TM node recognizes the electrical pulse as an event.
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PMC11621493
Previous observations suggested that PLA2G4D is expressed in several tissues, including skin, testis, placenta, stomach, small intestine, and brain (30, 31).
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PMC11543885
Decant and wash twice with freshly prepared quencher buffer, each wash lasting 1 min.
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PMC11047729
Right now, some of them are being used in current leukemia therapies, but there are a lot more perspectives for those compounds, and researching them could provide a lot of new treatment possibilities .
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PMC11367939
Thus, synapsin may simply enhance the clustering of vesicles, while ATG9A and synaptophysin possibly have intrinsic demixing properties or different sorting mechanisms.
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PMC11185260
All experiments were performed using mycoplasma-free cells.
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PMC10813895
It could refine prevention trial groups and show treatment effects.
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PMC11694346
Our probe demonstrates a significantly larger bathochromic shift and a lower LOD (83 nm for GSH, 49 nm for Cys and 80 nm for Hcy) relative to the reported probes.
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PMC11525028
Half-life time calculated using a linear model (n = 3).(T–V) Proliferation (T), colony formation (U), and migration and invasion (V) of WT and ac4C-MUT group, Scale bar: 100 μm (n = 3).
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PMC9429973
Most common all-grade treatment emergent AEs (TEAEs) were 47% fatigue, 43% neutropenia, 37% diarrhea, 30% nausea, and 30% constipation.
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PMC11470381
The half-center of each cell-half lies at the mid-point between the centroid of the whole cell and the centers of each half-cell (Figure 4A): xh1=Xc[j]widthPxl+Major[j]/8widthPxl*cos(φ) yh1=Yc[j]heightPxl-Major[j]/8heightPxl*sin(φ) xh2=Xc[j]widthPxl-Major[j]/8widthPxl*cos(φ) yh2=Yc[j]heightPxl+Major[j]/8heightPxl*sin(φ...
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PMC6617630
8Combinatorial effect of BET and BCL-2 inhibitor ABT-199 on WT-MYC and THL.
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PMC11361748
The normalized expression value of the target gene was determined by first averaging the relative expression of the target gene for each cDNA sample (ΔCq = average Cqtarget gene—average Cqreference gene), and then normalizing the relative expression value of the experimental condition to the control condition (2).
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PMC11025866
This study generates new hypotheses for control of the latency to lytic cycle switch of EBV and provides the first description of effects of the anti-convulsant drug VPM on global human cellular gene expression.
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PMC11502327
Chrysin and its derivatives have good anticancer activity against a variety of cancers.
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PMC11476222
Figure 3B shows a side-by-side comparison of the absolute methanol and Folch extraction methods.
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PMC10578720
However, the underlying molecular mechanism governing this phenomenon remains elusive.
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PMC11406030
These are localized in the nucleus, cytoplasm, transmembrane, and extracellular space.
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PMC8864075
Compounds.
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PMC9429973
Rates of complete remission (CR)/unconfirmed CR were 80% and partial remission were 13.3%.
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PMC9444294
Currently, molecular confirmation of a positive diagnosis of synovial sarcoma relies on RNA- or DNA-directed molecular techniques to detect the SS18-SSX fusion transcript and/or the t(X;18) chromosomal translocation.27 Interphase fluorescence in situ hybridization is commonly used on formalin-fixed, paraffin-embedded s...
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PMC11694346
BT-Boc and BT-DNBS were characterized by H/C NMR spectroscopy and ESI-MS spectrometry (ESI†).
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PMC11658074
c Gross images of skin texture in the four groups after UVB irradiation.
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PMC4839679
Data was collected for 1 min, in which 106 scans per CE species have been obtained.
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PMC11740207
It is hypothesized that VSELSCs may originate from PGCs, derived from the EpibCs during the early stages of embryogenesis, typically within the first weeks of human development (Kucia M. et al., 2008; Ratajczak et al., 2013b; Ratajczak et al., 2019; Barati et al., 2021; Bhartiya et al., 2022; Bhartiya et al., 2023a).
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PMC11604768
TRE units combined with minimal promoters (‘promoters’) regulate the expression of a Luc2 CDS containing 24 nucleotide barcodes in the 3’ UTR.
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PMC10976516
Tumor cells express calreticulin and secreted ATP as well as HMGB1.Miyamoto et al.CVB3 strainIntratumoral injections, with wild-type or UV-inactivated CVB3Single-dose CVB3 injection in subcutaneous xenotransplanted, KRAS human NSCLC cell line (A549, H2030, and H23) tumors.
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PMC2944824
The pRK5Hr expression vector was made by inserting the XbaI–SpeI fragment of the rat hr cDNA into the XbaI site of pRK5 as previously described .
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PMC5035325
EGFR-positive section (green).
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PMC9429973
Recipient mice were either bled and euthanized at day 14 following LN infusion to collect tissues or were kept for 56 days to record animal survival.
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PMC11188874
The effect of each sgRNA on pan-HLA-ABC expression on MMCLs was determined by flow cytometry.
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PMC10123657
For Full MS scan, a range of m/z 50–2200 was used with a resolution of 60,000 at m/z 1222.
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PMC7823217
Figure B is reproduced from with the permission of Springer Nature.
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PMC11463018
Design of triazolopyridines-based JAK/HDAC dual inhibitors.
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PMC11438317
To confirm the Y75 result, which was unexpected, we created double mutants of the three Tyr studied in SKAP2 to test the interaction of LP-DACS with any single Tyr of the three.
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PMC11612626
Pretreatment with compound A significantly increased pan–MHC-I HLA-ABC and HLA-B surface presentation in all MMCLs assayed.
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PMC11763111
Preliminary experiments indicated an increase in the CD8/CD4 ratio (Fig. 2A) and a two-fold increase in the expansion capacity of CAR-T cells without tumor stimulation (Fig. 2B) when B2M and CIITA were knocked down.
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PMC11407042
Check dissociation under the inverted microscope.
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PMC11707832
CSF, being more directly correlated with pathological changes in the CNS, contrasts with fibroblasts in the skin.
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PMC11763111
.Fig.
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PMC11672602
Control and con – untreated HEK293 and MDA-MB-231 cells, P1 and P – 1 μM paclitaxel, P2 – 5 μM paclitaxel, D1 and D – 1 μM DEAE-Dextran, D2 – 5 μM DEAE-Dextran, B and β – β-interferon treated cells. (
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PMC10988555
DMSO 0.1% (v/v) was used as the negative control and cisplatin and doxorubicin (DOX) were used as positive controls (common chemotherapeutic agents) for all cell lines.
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PMC10988555
Recrystallized from methanol/diethyl ether; red crystals; yield: 74%.
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PMC11377827
All showed reduced protein levels of the HIF-1 target gene CA9 (Fig. 2A).
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PMC11411131
Luciferase was inserted at the NheI and SalI sites in pCI-pur.
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PMC10094712
Figure 1A shows the results of the selection of optimal conditions for achieving high expression of the open reading frame (ORF) of the gene encoding the cysteine homologue of hSELENOM.
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PMC11321678
The x‐axis means the rank of TFs’ enrichment in this cluster and the y‐axis means motif enrichment score in this cluster.
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PMC11806818
The MUC-1 aptamer-modified Fe3O4 NPs magnetic beads are fixed on the surface of the magnetic glassy carbon electrode (MGCE) by inserting a magnet.
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PMC8143558
Much more evidence on the antifungal activity of saponins has been reported from various studies .
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PMC11585994
Our findings demonstrate that these nanoparticles exhibit potent anti-leukemia activity both in vitro and in vivo, while maintaining a favorable safety profile.
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PMC11046454
As shown in Figure 3F, based on the polyvalent effect of antigen targeting, a remarkable improvement in eradicating CEM cells was induced by HCR-AptPTK7-functionalized CAR-T, especially when using a low dose of Apt (EC50 = 0.66 nM).
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PMC9429973
We further determined the association of NHEJ pathway gene expression with clinical and molecular features.
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PMC11599565
Fixed cells were centrifuged at 500×g for 5 min and pellets were rinsed three times with PBST and incubated with primary antibodies (Table ST2) diluted in 1% BSA in PBST for 2 h at room temperature according to manufacturer’s recommendations.
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PMC9429973
In older pts (aged ≥65 years), numerically lower rates of CRS and serious AEs were observed.
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PMC11721295
Quantification of F4/80 and MPO showed a trend toward macrophages increasing in the ON group and decreasing in the OFF groups, albeit the finding was not statistically significant (Figure 4B and Supplemental Figure 4, B and C).
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PMC5363531
The PI3K catalytic subunit α (p110-α) was strongly expressed in untreated cells as well as following single agent dasatinib and PEM.
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PMC7723249
Although some studies have shown that the same type of viral proteins establish similar interactions/effects with cellular proteins for both viruses , further researches are needed to compare the biology of HAZV and CCHFV.
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PMC11013014
These interesting results will help us in the future with the development of new anticancer agents based on EA analogues that are capable of inhibiting the proliferation of cancer cells.
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PMC11674834
Investigations in cultured mammalian cells transfected with CYP1A2 and NAT2 concluded that the principal mechanism of 2,6-DMA genotoxicity is likely to be through redox cycling of intracellularly bound aminophenol/quinone imine structures to generate ROS rather than through formation of covalent DNA adducts .
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PMC11365983
The mean cilia lengths quantified by the two approaches, were concordant (automated: Foxc1 shRNA 0.85, control 1.0, P = 4.5 × 10; manual: Foxc1 shRNA 0.87, P = 1.6 × 10; Supplemental Fig. 1).
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PMC8623816
On the contrary, the RsRV5-infection strain D122 had an abnormal phenotype.
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PMC7185206
These monoclonal antibodies against PD-1 or PD-L1 improve survival for patients with melanoma, non-small cell lung cancer, renal cell carcinoma, bladder cancer, colorectal cancer, and other advanced malignancies.
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PMC11754432
Inhibition of EGFR activation increased STAT1 phosphorylation and in turn increased transcription and secretion of CCL2, CCL5 but reduced CXCL8.
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PMC7840816
p < 0.05 compared to normal thyroid tissue specimens. (
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PMC11066331
5 Three-dimensional visualization of PCA of 175 mass spectra recorded from 7 binary cell mixtures for mean-centered data in PC1-PC3 space (A) and standard deviation-divided data (B).
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PMC8414691
Cells were treated with 2 mM thymidine (Sigma, T9250) for 19 h, released from G1/S block in fresh media for 5 h, incubated with 40 nM nocodazole (Sigma, M1403) for 13 h, and harvested by mitotic shake-off.
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PMC8592717
Phenolic compounds are naturally present as secondary metabolites in plant-based sources such as fruits, vegetables, and spices.
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PMC11544122
Stimulation for V2R was 1 h, while for all others was for 30 min.
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PMC9587298
Several studies conducted by UHPLC-MS and NMR proved that the major active site of polyphenols to trap reactive dicarbonyl compounds, as MGO, is linked to the A-ring, more specifically, for flavonoids in the position C8 for mono-adducts, and C8 and C6 for the di-adducts (Hwang et al., 2018, Lv et al., 2011, Sang et al....
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PMC9429973
Results: From April 2008 to September 2020, 29 AML patients in CR1 received a total of 67 courses of HIDAC.
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PMC11700165
In contrast, when we used SYF cells that completely lack SFKs, we found that all the fusion kinases were localized in the cytoplasm, both in steady state and after activation (Fig. 3A,B).
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PMC9516447
Furthermore, the same study showed that GRP78 knockdown in a human lung cancer cell line (A427) bearing the same KRAS G12D mutation led to activation of the UPR and apoptotic markers, which could represent one mechanism whereby GRP78 deficiency suppresses tumor growth.
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PMC6650823
Thus, pentanoate might be of therapeutic relevance for the treatment of inflammatory and autoimmune diseases.
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PMC7812570
As analyzed by confocal microscopy (Fig. 1C), both GPI-m36.4 and GPI-FluIg03 colocalized with GM1 on the cell surface, indicating that they were indeed localized in the lipid raft sites within the plasma membrane.
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PMC10933092
Additionally, the constructed lncRNA-miRNA-mRNA ceRNA network exhibited good predictive ability.
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PMC9780037
Besides PEGylation and ionic liquids, B-DNA (the most commonly found DNA conformation) is also a potentially useful tool to improve cyt c stability.
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